thioctic acid has been researched along with Cataract, Membranous in 13 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 7.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
| "To evaluate whether alpha-lipoic acid (LA) inhibits lens opacity of naphthalene-induced cataract by altering post-translational modifications (PTMs) and protecting the chaperone activity of alpha-crystallins." | 7.76 | alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract. ( Chen, Y; Fang, Y; Jang, Y; Wei, L; Wu, X; Yan, G; Yi, L; Zhou, X, 2010) |
| "This study revealed a marked stereospecificity in the prevention of buthionine sulfoximine-induced cataract, and in the protection of lens antioxidants, in newborn rats by alpha-lipoate, R- and racemic alpha-lipoate decreased cataract formation from 100% (buthionine sulfoximine only) to 55% (buthionine sulfoximine + R-alpha-lipoic acid) and 40% (buthionine sulfoximine + rac-alpha-lipoic acid) (p<0." | 7.69 | Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. ( Maitra, I; Packer, L; Serbinova, E; Tritschler, HJ, 1996) |
| "The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 3.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
| "To evaluate whether alpha-lipoic acid (LA) inhibits lens opacity of naphthalene-induced cataract by altering post-translational modifications (PTMs) and protecting the chaperone activity of alpha-crystallins." | 3.76 | alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract. ( Chen, Y; Fang, Y; Jang, Y; Wei, L; Wu, X; Yan, G; Yi, L; Zhou, X, 2010) |
| "This study revealed a marked stereospecificity in the prevention of buthionine sulfoximine-induced cataract, and in the protection of lens antioxidants, in newborn rats by alpha-lipoate, R- and racemic alpha-lipoate decreased cataract formation from 100% (buthionine sulfoximine only) to 55% (buthionine sulfoximine + R-alpha-lipoic acid) and 40% (buthionine sulfoximine + rac-alpha-lipoic acid) (p<0." | 3.69 | Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats. ( Maitra, I; Packer, L; Serbinova, E; Tritschler, HJ, 1996) |
| "Diabetic cataracts are caused by an elevation of polyols within the lens of the eye catalyzed by the enzyme aldose reductase." | 2.41 | Natural therapies for ocular disorders, part two: cataracts and glaucoma. ( Head, KA, 2001) |
| "Cataract was assessed using cross line grey scale measurement." | 1.39 | Alpha lipoic acid protects lens from H(2)O(2)-induced cataract by inhibiting apoptosis of lens epithelial cells and inducing activation of anti-oxidative enzymes. ( Jia, SB; Li, Y; Liu, YZ; Shi, JM, 2013) |
| "Formation of lens opacities in vitro was correlated with lactate dehydrogenase (LDH) leakage into the incubation medium." | 1.29 | Modelling cortical cataractogenesis 17: in vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis. ( Handelman, GJ; Kilic, F; Packer, L; Serbinova, E; Trevithick, JR, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, Y | 1 |
| Liu, YZ | 1 |
| Shi, JM | 1 |
| Jia, SB | 1 |
| Kan, E | 1 |
| Kiliçkan, E | 1 |
| Ayar, A | 1 |
| Çolak, R | 1 |
| Chen, Y | 1 |
| Yi, L | 1 |
| Yan, G | 1 |
| Fang, Y | 1 |
| Jang, Y | 1 |
| Wu, X | 1 |
| Zhou, X | 1 |
| Wei, L | 1 |
| Sun, L | 1 |
| Zhang, JS | 1 |
| Maitra, I | 2 |
| Serbinova, E | 3 |
| Trischler, H | 1 |
| Packer, L | 6 |
| Tritschler, HJ | 1 |
| Kilic, F | 2 |
| Handelman, GJ | 2 |
| Trevithick, JR | 3 |
| Bantseev, V | 1 |
| Bhardwaj, R | 1 |
| Rathbun, W | 1 |
| Nagasawa, H | 1 |
| Traber, K | 1 |
| Tsang, K | 1 |
| Head, KA | 1 |
| Kraemer, K | 1 |
| Rimbach, G | 1 |
| Bilska, A | 1 |
| Włodek, L | 1 |
4 reviews available for thioctic acid and Cataract, Membranous
| Article | Year |
|---|---|
Antioxidant properties of lipoic acid and its therapeutic effects in prevention of diabetes complications and cataracts.
Topics: Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Cataract; Diabetes Mellitus, Experim | 1994 |
Natural therapies for ocular disorders, part two: cataracts and glaucoma.
Topics: Cataract; Diabetes Complications; Diabetes Mellitus; Female; Glaucoma; Glucose; Glutathione; Humans; | 2001 |
Molecular aspects of lipoic acid in the prevention of diabetes complications.
Topics: Antioxidants; Biological Availability; Cataract; Diabetes Complications; Diabetes Mellitus; Diabetic | 2001 |
[Biologic properties of lipoic acid].
Topics: Acquired Immunodeficiency Syndrome; Aging; Animals; Antioxidants; Cataract; Decarboxylation; Diabeti | 2002 |
9 other studies available for thioctic acid and Cataract, Membranous
| Article | Year |
|---|---|
Alpha lipoic acid protects lens from H(2)O(2)-induced cataract by inhibiting apoptosis of lens epithelial cells and inducing activation of anti-oxidative enzymes.
Topics: Animals; Antioxidants; Apoptosis; Cataract; Epithelial Cells; Glutathione; Hydrogen Peroxide; L-Lact | 2013 |
Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice.
Topics: Animals; Antioxidants; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Pr | 2015 |
alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract.
Topics: Acetylation; alpha-Crystallins; Animals; Antioxidants; Cataract; Chromatography, High Pressure Liqui | 2010 |
[Effects of DL-alpha-lipoic acid on the experimentally induced diabetic cataract in rats].
Topics: Animals; Antioxidants; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Disease Models, Ani | 2004 |
Alpha-lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats.
Topics: Animals; Buthionine Sulfoximine; Cataract; Female; Free Radicals; Glutamate-Cysteine Ligase; Glutath | 1995 |
Stereospecific effects of R-lipoic acid on buthionine sulfoximine-induced cataract formation in newborn rats.
Topics: Animals; Animals, Newborn; Ascorbic Acid; Buthionine Sulfoximine; Cataract; Female; Glutathione; Glu | 1996 |
Modelling cortical cataractogenesis 17: in vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucose; In Vitr | 1995 |
Antioxidants and cataract: (cataract induction in space environment and application to terrestrial aging cataract).
Topics: Animals; Antioxidants; Ascorbic Acid; Carbolines; Cataract; Cysteine; Dose-Response Relationship, Ra | 1997 |
Modelling cortical cataractogenesis XX. In vitro effect of alpha-lipoic acid on glutathione concentrations in lens in model diabetic cataractogenesis.
Topics: Animals; Cataract; Culture Techniques; Diabetes Complications; Diabetes Mellitus; Disease Models, An | 1998 |