thioctic acid and Cardiometabolic Syndrome
thioctic acid has been researched along with Cardiometabolic Syndrome in 10 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Cardiometabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components not only include metabolic dysfunctions of METABOLIC SYNDROME but also HYPERTENSION, and ABDOMINAL OBESITY.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes." | 9.17 | Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. ( Botti, G; Brillante, G; Capasso, I; Cavalcanti, E; Ciliberto, G; Crispo, A; D'Aiuto, G; D'Aiuto, M; De Laurentiis, M; Esposito, E; Esposito, G; Frasci, G; Fucito, A; Grimaldi, M; Maurea, N; Montella, M, 2013) |
"Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes." | 5.17 | Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. ( Botti, G; Brillante, G; Capasso, I; Cavalcanti, E; Ciliberto, G; Crispo, A; D'Aiuto, G; D'Aiuto, M; De Laurentiis, M; Esposito, E; Esposito, G; Frasci, G; Fucito, A; Grimaldi, M; Maurea, N; Montella, M, 2013) |
"We performed an open-label randomized controlled study to evaluate the role of a nutraceutical containing Q10 coenzyme, Krill-oil, lipoic acid, resveratrol, Vitis vinifera seed oil, vitamin E and selenium in addition to etanercept therapy for patients affected by psoriasis and metabolic syndrome." | 5.17 | Efficacy of food supplement to improve metabolic syndrome parameters in patients affected by moderate to severe psoriasis during anti-TNFα treatment. ( Balduzzi, V; Bernardini, N; La Viola, G; Mancini, MT; Nicolucci, F; Pampena, R; Potenza, C; Proietti, I; Skroza, N; Soccodato, V; Tolino, E; Zuber, S, 2013) |
"To evaluate the effects of the combination of d-chiro-inositol (DCI) and alpha lipoic acid on menses and metabolic disorders in women with polycystic ovary syndrome (PCOS)." | 3.81 | d-chiro-Inositol and alpha lipoic acid treatment of metabolic and menses disorders in women with PCOS. ( Bartolo, M; Caruso, S; Cianci, A; Falduzzi, C; Fichera, M; Panella, M, 2015) |
" In other rats, glucose, insulin, uric acid, and insulin sensitivity index, were determined before and after fructose or lipoic acid plus fructose." | 3.79 | A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress. ( Hong, E; Moreno, JA, 2013) |
"On the other hand, α-LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation." | 2.82 | Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review. ( Ghasemzadeh Rahbardar, M; Hosseinzadeh, H; Mehri, S; Najafi, N, 2022) |
"The metabolic syndrome is associated with abnormal glucose and lipid metabolism, insulin resistance, increased oxidative stress and pro-inflammatory activity that increase the risk of type 2 diabetes and cardiovascular disease." | 2.78 | The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. ( Berry, EA; De Jong, SA; Manning, PJ; Ryalls, AR; Sutherland, WH; Walker, RJ; Williams, SM, 2013) |
"The metabolic syndrome is associated with increased angiotensin II activity, induction of a proinflammatory and oxidative state, and endothelial dysfunction." | 2.71 | Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. ( Cheema, FA; Khan, BV; Khan-Merchant, N; Menon, RG; Mir, MQ; Parthasarathy, S; Sola, S, 2005) |
Research
Studies (10)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (20.00) | 29.6817 |
2010's | 7 (70.00) | 24.3611 |
2020's | 1 (10.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Najafi, N | 1 |
Mehri, S | 1 |
Ghasemzadeh Rahbardar, M | 1 |
Hosseinzadeh, H | 1 |
Chen, Y | 1 |
Zhou, Z | 1 |
Li, XX | 1 |
Wang, T | 1 |
Rowin, J | 1 |
Capasso, I | 1 |
Esposito, E | 1 |
Maurea, N | 1 |
Montella, M | 1 |
Crispo, A | 1 |
De Laurentiis, M | 1 |
D'Aiuto, M | 1 |
Frasci, G | 1 |
Botti, G | 1 |
Grimaldi, M | 1 |
Cavalcanti, E | 1 |
Esposito, G | 1 |
Fucito, A | 1 |
Brillante, G | 1 |
D'Aiuto, G | 1 |
Ciliberto, G | 1 |
Skroza, N | 1 |
Proietti, I | 1 |
Bernardini, N | 1 |
La Viola, G | 1 |
Nicolucci, F | 1 |
Pampena, R | 1 |
Tolino, E | 1 |
Zuber, S | 1 |
Mancini, MT | 1 |
Soccodato, V | 1 |
Balduzzi, V | 1 |
Potenza, C | 1 |
Cianci, A | 1 |
Panella, M | 1 |
Fichera, M | 1 |
Falduzzi, C | 1 |
Bartolo, M | 1 |
Caruso, S | 1 |
Moreno, JA | 1 |
Hong, E | 1 |
Manning, PJ | 1 |
Sutherland, WH | 1 |
Williams, SM | 1 |
Walker, RJ | 1 |
Berry, EA | 1 |
De Jong, SA | 1 |
Ryalls, AR | 1 |
Sola, S | 1 |
Mir, MQ | 1 |
Cheema, FA | 1 |
Khan-Merchant, N | 1 |
Menon, RG | 1 |
Parthasarathy, S | 1 |
Khan, BV | 1 |
Pershadsingh, HA | 1 |
Clinical Trials (2)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851] | 90 participants (Anticipated) | Interventional | 2015-05-07 | Recruiting | |||
Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia: A Randomized, Double-blind, Placebo-controlled Trial[NCT03788759] | Phase 2/Phase 3 | 48 participants (Actual) | Interventional | 2019-09-01 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Reviews
3 reviews available for thioctic acid and Cardiometabolic Syndrome
Article | Year |
---|---|
Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review.
Topics: AMP-Activated Protein Kinases; Cholesterol; Humans; Insulin Resistance; Lipoproteins, LDL; Metabolic | 2022 |
Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives.
Topics: Acetylcarnitine; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Diet; Diet Therapy; Dietary Supp | 2019 |
Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome.
Topics: Adipogenesis; Animals; Antioxidants; Humans; Metabolic Syndrome; Phosphotransferases (Phosphate Grou | 2007 |
Trials
4 trials available for thioctic acid and Cardiometabolic Syndrome
Article | Year |
---|---|
Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial.
Topics: Aged; Biomarkers; Blood Glucose; Body Mass Index; Breast Neoplasms; Caloric Restriction; Cholesterol | 2013 |
Efficacy of food supplement to improve metabolic syndrome parameters in patients affected by moderate to severe psoriasis during anti-TNFα treatment.
Topics: Adult; Animals; Antioxidants; Biomarkers; Body Mass Index; Cholesterol, HDL; Dietary Fats, Unsaturat | 2013 |
The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome.
Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Antioxidants; Blood Glucose; Dietary Supplements; Doubl | 2013 |
Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Antioxidants; Biomarkers; Biphenyl Compounds; Brachi | 2005 |
Other Studies
3 other studies available for thioctic acid and Cardiometabolic Syndrome
Article | Year |
---|---|
Research on the protective effects of antioxidants on metabolic syndrome induced by thyroid dysfunction.
Topics: Adult; Anthropometry; Antioxidants; Biomarkers; Cross-Sectional Studies; Female; Humans; Hypothyroid | 2017 |
d-chiro-Inositol and alpha lipoic acid treatment of metabolic and menses disorders in women with PCOS.
Topics: Adolescent; Adult; Drug Therapy, Combination; Female; Humans; Inositol; Menstruation Disturbances; M | 2015 |
A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress.
Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Dose-Response Relationship, Drug; Fruc | 2013 |