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thioctic acid and Cardiometabolic Syndrome

thioctic acid has been researched along with Cardiometabolic Syndrome in 10 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Cardiometabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components not only include metabolic dysfunctions of METABOLIC SYNDROME but also HYPERTENSION, and ABDOMINAL OBESITY.

Research Excerpts

ExcerptRelevanceReference
"Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes."9.17Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. ( Botti, G; Brillante, G; Capasso, I; Cavalcanti, E; Ciliberto, G; Crispo, A; D'Aiuto, G; D'Aiuto, M; De Laurentiis, M; Esposito, E; Esposito, G; Frasci, G; Fucito, A; Grimaldi, M; Maurea, N; Montella, M, 2013)
"Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes."5.17Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. ( Botti, G; Brillante, G; Capasso, I; Cavalcanti, E; Ciliberto, G; Crispo, A; D'Aiuto, G; D'Aiuto, M; De Laurentiis, M; Esposito, E; Esposito, G; Frasci, G; Fucito, A; Grimaldi, M; Maurea, N; Montella, M, 2013)
"We performed an open-label randomized controlled study to evaluate the role of a nutraceutical containing Q10 coenzyme, Krill-oil, lipoic acid, resveratrol, Vitis vinifera seed oil, vitamin E and selenium in addition to etanercept therapy for patients affected by psoriasis and metabolic syndrome."5.17Efficacy of food supplement to improve metabolic syndrome parameters in patients affected by moderate to severe psoriasis during anti-TNFα treatment. ( Balduzzi, V; Bernardini, N; La Viola, G; Mancini, MT; Nicolucci, F; Pampena, R; Potenza, C; Proietti, I; Skroza, N; Soccodato, V; Tolino, E; Zuber, S, 2013)
"To evaluate the effects of the combination of d-chiro-inositol (DCI) and alpha lipoic acid on menses and metabolic disorders in women with polycystic ovary syndrome (PCOS)."3.81d-chiro-Inositol and alpha lipoic acid treatment of metabolic and menses disorders in women with PCOS. ( Bartolo, M; Caruso, S; Cianci, A; Falduzzi, C; Fichera, M; Panella, M, 2015)
" In other rats, glucose, insulin, uric acid, and insulin sensitivity index, were determined before and after fructose or lipoic acid plus fructose."3.79A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress. ( Hong, E; Moreno, JA, 2013)
"On the other hand, α-LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation."2.82Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review. ( Ghasemzadeh Rahbardar, M; Hosseinzadeh, H; Mehri, S; Najafi, N, 2022)
"The metabolic syndrome is associated with abnormal glucose and lipid metabolism, insulin resistance, increased oxidative stress and pro-inflammatory activity that increase the risk of type 2 diabetes and cardiovascular disease."2.78The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome. ( Berry, EA; De Jong, SA; Manning, PJ; Ryalls, AR; Sutherland, WH; Walker, RJ; Williams, SM, 2013)
"The metabolic syndrome is associated with increased angiotensin II activity, induction of a proinflammatory and oxidative state, and endothelial dysfunction."2.71Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study. ( Cheema, FA; Khan, BV; Khan-Merchant, N; Menon, RG; Mir, MQ; Parthasarathy, S; Sola, S, 2005)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's7 (70.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Najafi, N1
Mehri, S1
Ghasemzadeh Rahbardar, M1
Hosseinzadeh, H1
Chen, Y1
Zhou, Z1
Li, XX1
Wang, T1
Rowin, J1
Capasso, I1
Esposito, E1
Maurea, N1
Montella, M1
Crispo, A1
De Laurentiis, M1
D'Aiuto, M1
Frasci, G1
Botti, G1
Grimaldi, M1
Cavalcanti, E1
Esposito, G1
Fucito, A1
Brillante, G1
D'Aiuto, G1
Ciliberto, G1
Skroza, N1
Proietti, I1
Bernardini, N1
La Viola, G1
Nicolucci, F1
Pampena, R1
Tolino, E1
Zuber, S1
Mancini, MT1
Soccodato, V1
Balduzzi, V1
Potenza, C1
Cianci, A1
Panella, M1
Fichera, M1
Falduzzi, C1
Bartolo, M1
Caruso, S1
Moreno, JA1
Hong, E1
Manning, PJ1
Sutherland, WH1
Williams, SM1
Walker, RJ1
Berry, EA1
De Jong, SA1
Ryalls, AR1
Sola, S1
Mir, MQ1
Cheema, FA1
Khan-Merchant, N1
Menon, RG1
Parthasarathy, S1
Khan, BV1
Pershadsingh, HA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851]90 participants (Anticipated)Interventional2015-05-07Recruiting
Alpha-lipoic Acid Adjunctive Therapy in Schizophrenia: A Randomized, Double-blind, Placebo-controlled Trial[NCT03788759]Phase 2/Phase 348 participants (Actual)Interventional2019-09-01Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for thioctic acid and Cardiometabolic Syndrome

ArticleYear
Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review.
    Phytotherapy research : PTR, 2022, Volume: 36, Issue:6

    Topics: AMP-Activated Protein Kinases; Cholesterol; Humans; Insulin Resistance; Lipoproteins, LDL; Metabolic

2022
Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives.
    Muscle & nerve, 2019, Volume: 60, Issue:2

    Topics: Acetylcarnitine; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Diet; Diet Therapy; Dietary Supp

2019
Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome.
    Expert opinion on investigational drugs, 2007, Volume: 16, Issue:3

    Topics: Adipogenesis; Animals; Antioxidants; Humans; Metabolic Syndrome; Phosphotransferases (Phosphate Grou

2007

Trials

4 trials available for thioctic acid and Cardiometabolic Syndrome

ArticleYear
Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial.
    Trials, 2013, Aug-28, Volume: 14

    Topics: Aged; Biomarkers; Blood Glucose; Body Mass Index; Breast Neoplasms; Caloric Restriction; Cholesterol

2013
Efficacy of food supplement to improve metabolic syndrome parameters in patients affected by moderate to severe psoriasis during anti-TNFα treatment.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2013, Volume: 148, Issue:6

    Topics: Adult; Animals; Antioxidants; Biomarkers; Body Mass Index; Cholesterol, HDL; Dietary Fats, Unsaturat

2013
The effect of lipoic acid and vitamin E therapies in individuals with the metabolic syndrome.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2013, Volume: 23, Issue:6

    Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Antioxidants; Blood Glucose; Dietary Supplements; Doubl

2013
Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study.
    Circulation, 2005, Jan-25, Volume: 111, Issue:3

    Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Antioxidants; Biomarkers; Biphenyl Compounds; Brachi

2005

Other Studies

3 other studies available for thioctic acid and Cardiometabolic Syndrome

ArticleYear
Research on the protective effects of antioxidants on metabolic syndrome induced by thyroid dysfunction.
    European review for medical and pharmacological sciences, 2017, Volume: 21, Issue:10

    Topics: Adult; Anthropometry; Antioxidants; Biomarkers; Cross-Sectional Studies; Female; Humans; Hypothyroid

2017
d-chiro-Inositol and alpha lipoic acid treatment of metabolic and menses disorders in women with PCOS.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2015, Volume: 31, Issue:6

    Topics: Adolescent; Adult; Drug Therapy, Combination; Female; Humans; Inositol; Menstruation Disturbances; M

2015
A single oral dose of fructose induces some features of metabolic syndrome in rats: role of oxidative stress.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2013, Volume: 23, Issue:6

    Topics: Administration, Oral; Animals; Blood Glucose; Blood Pressure; Dose-Response Relationship, Drug; Fruc

2013
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