thioctic acid has been researched along with Cardiac Toxicity in 2 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This randomized double-blind placebo-controlled prospective study included 64 patients with breast cancer who were randomized into control group (n = 32) which received 4 cycles of doxorubicin plus cyclophosphamide (every 21 days) followed by weekly doses of paclitaxel for 12 weeks plus placebo tablets once daily and ALA group (n = 32) which received the same chemotherapeutic regimen plus ALA 600 once daily for 6 months." | 9.51 | Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. ( Elshafiey, RA; Elzawawy, S; Ghoneim, A; Mostafa, TM; Werida, RH, 2022) |
| "This randomized double-blind placebo-controlled prospective study included 64 patients with breast cancer who were randomized into control group (n = 32) which received 4 cycles of doxorubicin plus cyclophosphamide (every 21 days) followed by weekly doses of paclitaxel for 12 weeks plus placebo tablets once daily and ALA group (n = 32) which received the same chemotherapeutic regimen plus ALA 600 once daily for 6 months." | 5.51 | Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. ( Elshafiey, RA; Elzawawy, S; Ghoneim, A; Mostafa, TM; Werida, RH, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Werida, RH | 1 |
| Elshafiey, RA | 1 |
| Ghoneim, A | 1 |
| Elzawawy, S | 1 |
| Mostafa, TM | 1 |
| Gong, F | 1 |
| Jin, J | 1 |
| Li, H | 1 |
| Mao, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Role of Alpha-Lipoic Acid Against Chemotherapy Induced Toxicities in Breast Cancer Patients[NCT03908528] | 64 participants (Actual) | Interventional | 2019-03-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for thioctic acid and Cardiac Toxicity
| Article | Year |
|---|---|
Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cardiotoxicity; Doxorubicin; Femal | 2022 |
1 other study available for thioctic acid and Cardiac Toxicity
| Article | Year |
|---|---|
Alpha-Lipoic Acid Protects Against Doxorubicin-Induced Cardiotoxicity by Regulating Pyruvate Dehydrogenase Kinase 4.
Topics: Animals; Apoptosis; Cardiotoxicity; Doxorubicin; Mice; Myocytes, Cardiac; Oxidative Stress; Reactive | 2022 |