thioctic acid has been researched along with Burning Mouth Syndrome in 26 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Burning Mouth Syndrome: A group of painful oral symptoms associated with a burning or similar sensation. There is usually a significant organic component with a degree of functional overlay; it is not limited to the psychophysiologic group of disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alpha-lipoic acid (ALA) is a potent antioxidant mitochondrial coenzyme, trometamol salt of thioctic acid, shown in clinical studies to be neuroprotective and in a preliminary study to have an effect on the symptomatology of Burning Mouth Syndrome (BMS)." | 9.10 | Burning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies. ( Femiano, F, 2002) |
| "Our results demonstrate the similar effectiveness of capsaicin and alpha-lipoic acid in controlling the symptoms of burning mouth syndrome." | 5.14 | Different therapeutic strategies for burning mouth syndrome: preliminary data. ( Capaccio, P; Marino, R; Pignataro, L; Spadari, F; Torretta, S, 2010) |
| "Alpha-lipoic acid (ALA) is a potent antioxidant mitochondrial coenzyme, trometamol salt of thioctic acid, shown in clinical studies to be neuroprotective and in a preliminary study to have an effect on the symptomatology of Burning Mouth Syndrome (BMS)." | 5.10 | Burning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies. ( Femiano, F, 2002) |
| "Burning mouth syndrome is a chronic idiopathic intractable intraoral dysaesthesia that remains a challenge to clinicians due to its poorly understood pathogenesis and inconsistent response to various treatments." | 2.82 | A systematic review of treatment for patients with burning mouth syndrome. ( Hoffmann, J; Renton, T; Smith, JG; Tan, HL, 2022) |
| "Gabapentin was seen in one study to work alone and synergistically with ALA." | 2.58 | Burning mouth syndrome: a systematic review of treatments. ( Han, P; Inman, JC; Kim, Y; Liu, YF; Yoo, T, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (46.15) | 29.6817 |
| 2010's | 11 (42.31) | 24.3611 |
| 2020's | 3 (11.54) | 2.80 |
| Authors | Studies |
|---|---|
| Alqahtani, SS | 1 |
| Tan, HL | 1 |
| Smith, JG | 1 |
| Hoffmann, J | 1 |
| Renton, T | 1 |
| Orliaguet, M | 1 |
| Misery, L | 1 |
| Barbosa, NG | 1 |
| Gonzaga, AKG | 1 |
| de Sena Fernandes, LL | 1 |
| da Fonseca, AG | 1 |
| Queiroz, SIML | 1 |
| Lemos, TMAM | 1 |
| da Silveira, ÉJD | 1 |
| de Medeiros, AMC | 1 |
| Oberoi-Jassal, R | 1 |
| Portman, D | 1 |
| Smith, J | 1 |
| Rajasekhara, S | 1 |
| Desai, VV | 1 |
| Donovan, KA | 1 |
| Chang, YD | 1 |
| de Souza, IF | 1 |
| Mármora, BC | 1 |
| Rados, PV | 1 |
| Visioli, F | 1 |
| Palacios-Sánchez, B | 1 |
| Moreno-López, LA | 1 |
| Cerero-Lapiedra, R | 1 |
| Llamas-Martínez, S | 1 |
| Esparza-Gómez, G | 1 |
| Kisely, S | 1 |
| Forbes, M | 1 |
| Sawyer, E | 1 |
| Black, E | 1 |
| Lalloo, R | 1 |
| Liu, YF | 1 |
| Kim, Y | 1 |
| Yoo, T | 1 |
| Han, P | 1 |
| Inman, JC | 1 |
| Carbone, M | 1 |
| Pentenero, M | 1 |
| Carrozzo, M | 1 |
| Ippolito, A | 1 |
| Gandolfo, S | 1 |
| López-Jornet, P | 1 |
| Camacho-Alonso, F | 1 |
| Leon-Espinosa, S | 1 |
| Cavalcanti, DR | 1 |
| da Silveira, FR | 1 |
| Cervigón González, I | 1 |
| Torres, LM | 1 |
| Palomo, A | 1 |
| Marino, R | 1 |
| Torretta, S | 1 |
| Capaccio, P | 1 |
| Pignataro, L | 1 |
| Spadari, F | 1 |
| López-D'alessandro, E | 1 |
| Escovich, L | 1 |
| Becker, S | 1 |
| Schmidt, C | 1 |
| Berghaus, A | 1 |
| Tschiesner, U | 1 |
| Olzowy, B | 1 |
| Reichel, O | 1 |
| de Moraes, M | 1 |
| do Amaral Bezerra, BA | 1 |
| da Rocha Neto, PC | 1 |
| de Oliveira Soares, AC | 1 |
| Pinto, LP | 1 |
| de Lisboa Lopes Costa, A | 1 |
| Gerlinger, I | 1 |
| Femiano, F | 6 |
| Scully, C | 4 |
| Gombos, F | 4 |
| Scardina, GA | 1 |
| Pisano, T | 1 |
| Messina, P | 1 |
| Lanza, A | 1 |
| Buonaiuto, C | 1 |
| Nunziata, M | 1 |
| Cuccurullo, L | 1 |
| Cirillo, N | 1 |
| Steele, JC | 1 |
| Bruce, AJ | 1 |
| Drage, LA | 1 |
| Rogers, RS | 1 |
| Busciolano, M | 1 |
| De Luca, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Low Intensity Laser Combined With Topical Clonazepam for the Treatment of Burning Mouth Syndrome[NCT04313907] | Phase 4 | 27 participants (Anticipated) | Interventional | 2019-08-16 | Recruiting | ||
| A Prospective Study on the Treatment of Burning Mouth Syndrome With Integration of Traditional Chinese Medicine(TCM) and Western Medicine Based on TCM Syndrome Differentiation[NCT04189367] | Phase 3 | 80 participants (Anticipated) | Interventional | 2020-06-20 | Not yet recruiting | ||
| Efficacy of Gabapentin for Post-Covid-19 Olfactory Dysfunction[NCT05184192] | Phase 2 | 50 participants (Anticipated) | Interventional | 2022-01-10 | Enrolling by invitation | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for thioctic acid and Burning Mouth Syndrome
| Article | Year |
|---|---|
The efficiency of alpha-lipoic acid in the treatment of burning mouth syndrome: a systematic review.
Topics: Burning Mouth Syndrome; Humans; Pain; Randomized Controlled Trials as Topic; Thioctic Acid; Treatmen | 2021 |
A systematic review of treatment for patients with burning mouth syndrome.
Topics: Burning Mouth Syndrome; Capsaicin; Clonazepam; Humans; Pain; Thioctic Acid | 2022 |
Neuropathic and Psychogenic Components of Burning Mouth Syndrome: A Systematic Review.
Topics: Burning Mouth Syndrome; Capsaicin; Cytokines; Humans; Low-Level Light Therapy; Neuralgia; Pain; Pain | 2021 |
Treatment modalities for burning mouth syndrome: a systematic review.
Topics: Analgesics; Anti-Inflammatory Agents; Antidepressive Agents; Antioxidants; Burning Mouth Syndrome; H | 2018 |
A systematic review of randomized trials for the treatment of burning mouth syndrome.
Topics: Burning Mouth Syndrome; Capsaicin; Humans; Pain; Pain Management; Pain Measurement; Psychotherapy; Q | 2016 |
Burning mouth syndrome: a systematic review of treatments.
Topics: Amines; Analgesics; Antioxidants; Burning Mouth Syndrome; Capsaicin; Clonazepam; Cyclohexanecarboxyl | 2018 |
Randomized trials for the treatment of burning mouth syndrome: an evidence-based review of the literature.
Topics: Antioxidants; Burning Mouth Syndrome; Capsaicin; Clonazepam; Evidence-Based Dentistry; GABA Modulato | 2012 |
[Burning sensation in oral cavity--burning mouth syndrome in everyday medical practice].
Topics: Acetamides; Amines; Anti-Anxiety Agents; Antidepressive Agents; Antioxidants; Burning Mouth Syndrome | 2012 |
[Burning mouth syndrome].
Topics: Age Factors; Aged; Amines; Analgesics; Anti-Anxiety Agents; Antioxidants; Burning Mouth Syndrome; Cl | 2007 |
11 trials available for thioctic acid and Burning Mouth Syndrome
| Article | Year |
|---|---|
Evaluation of laser therapy and alpha-lipoic acid for the treatment of burning mouth syndrome: a randomized clinical trial.
Topics: Burning Mouth Syndrome; Combined Modality Therapy; Female; Humans; Low-Level Light Therapy; Male; Mi | 2018 |
Alpha lipoic acid efficacy in burning mouth syndrome. A controlled clinical trial.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Burning Mouth Syndrome; Double-Blind Method; Female; H | 2015 |
Lack of efficacy of alpha-lipoic acid in burning mouth syndrome: a double-blind, randomized, placebo-controlled study.
Topics: Aged; Burning Mouth Syndrome; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle A | 2009 |
Efficacy of alpha lipoic acid in burning mouth syndrome: a randomized, placebo-treatment study.
Topics: Aged; Antioxidants; Burning Mouth Syndrome; Double-Blind Method; Female; Humans; Male; Middle Aged; | 2009 |
Alpha lipoic acid in burning mouth syndrome--a randomized double-blind placebo-controlled trial.
Topics: Adult; Aged; Antioxidants; Burning Mouth Syndrome; Cross-Over Studies; Double-Blind Method; Female; | 2009 |
Different therapeutic strategies for burning mouth syndrome: preliminary data.
Topics: Administration, Oral; Administration, Topical; Antioxidants; Boric Acids; Burning Mouth Syndrome; Ca | 2010 |
Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of Burning Mouth Syndrome: a randomized, double-blind, placebo controlled trial.
Topics: Amines; Burning Mouth Syndrome; Calcium Channel Blockers; Cyclohexanecarboxylic Acids; Double-Blind | 2011 |
Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy.
Topics: Adult; Aged; Antioxidants; Burning Mouth Syndrome; Cellulose; Chi-Square Distribution; Double-Blind | 2002 |
Burning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies.
Topics: Administration, Oral; Adult; Aged; Bethanechol; Burning Mouth Syndrome; Cohort Studies; Drug Combina | 2002 |
Idiopathic dysgeusia; an open trial of alpha lipoic acid (ALA) therapy.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Antioxidants; Burning Mouth Syndrome; Carboxymethylce | 2002 |
Burning mouth syndrome (BMS): controlled open trial of the efficacy of alpha-lipoic acid (thioctic acid) on symptomatology.
Topics: Administration, Oral; Adult; Aged; Antioxidants; Burning Mouth Syndrome; Case-Control Studies; Cellu | 2000 |
6 other studies available for thioctic acid and Burning Mouth Syndrome
| Article | Year |
|---|---|
Burning Mouth Pain: A Case Report.
Topics: Analgesics; Burning Mouth Syndrome; Carcinoma, Squamous Cell; Clonazepam; Female; Fentanyl; Gabapent | 2018 |
[Burning mouth syndrome and alpha-lipoic acid].
Topics: Aged; Antioxidants; Anxiety Disorders; Burning Mouth Syndrome; Candidiasis, Oral; Depressive Disorde | 2009 |
Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study.
Topics: Adult; Aged; Aged, 80 and over; Burning Mouth Syndrome; Cohort Studies; Esophageal pH Monitoring; Fe | 2011 |
Burning mouth syndrome: the efficacy of lipoic acid on subgroups.
Topics: Adult; Aged; Antioxidants; Burning Mouth Syndrome; Chi-Square Distribution; Female; Humans; Male; Mi | 2004 |
Burning mouth syndrome and burning mouth in hypothyroidism: proposal for a diagnostic and therapeutic protocol.
Topics: Adult; Aged; Antioxidants; Burning Mouth Syndrome; Case-Control Studies; Chi-Square Distribution; Cl | 2008 |
Alpha-lipoic acid treatment of 31 patients with sore, burning mouth.
Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Attitude to Health; Burning Mouth Syndrome; Cohort Stu | 2008 |