Page last updated: 2024-10-19

thioctic acid and Breast Cancer

thioctic acid has been researched along with Breast Cancer in 30 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Research Excerpts

ExcerptRelevanceReference
"This randomized double-blind placebo-controlled prospective study included 64 patients with breast cancer who were randomized into control group (n = 32) which received 4 cycles of doxorubicin plus cyclophosphamide (every 21 days) followed by weekly doses of paclitaxel for 12 weeks plus placebo tablets once daily and ALA group (n = 32) which received the same chemotherapeutic regimen plus ALA 600 once daily for 6 months."9.51Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. ( Elshafiey, RA; Elzawawy, S; Ghoneim, A; Mostafa, TM; Werida, RH, 2022)
"Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes."9.17Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. ( Botti, G; Brillante, G; Capasso, I; Cavalcanti, E; Ciliberto, G; Crispo, A; D'Aiuto, G; D'Aiuto, M; De Laurentiis, M; Esposito, E; Esposito, G; Frasci, G; Fucito, A; Grimaldi, M; Maurea, N; Montella, M, 2013)
" Motivated by the relatively high cytotoxic activity of gold complexes, such as Auranofin (approved to treat rheumatoid arthritis), for the treatment of various diseases, we anticipated that gold peptide bioconjugates would present interesting candidates for novel breast cancer therapies."7.91Bioconjugation of Cyclometalated Gold(III) Lipoic Acid Fragments to Linear and Cyclic Breast Cancer Targeting Peptides. ( Metzler-Nolte, N; Slootweg, JC; Śmiłowicz, D, 2019)
"To evaluate the efficacy of combination of alpha-lipoic acid and acetylcholinesterase inhibitor (ipidacrine hydrochloride) to prevent the development and improve the course of paclitaxel-induced peripheral neuropathy (PIPN) in patients with breast cancer according to the Total Neuropathy Score."5.51EVALUATION OF THE EFFICIENCY OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE FOR THE PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ACCORDING TO THE TOTAL NEUROPATHY SCORE. ( Holotiuk, IS; Holotiuk, SI; Holotiuk, VV; Kryzhanivska, AY; Maliborska, SV, 2022)
"This randomized double-blind placebo-controlled prospective study included 64 patients with breast cancer who were randomized into control group (n = 32) which received 4 cycles of doxorubicin plus cyclophosphamide (every 21 days) followed by weekly doses of paclitaxel for 12 weeks plus placebo tablets once daily and ALA group (n = 32) which received the same chemotherapeutic regimen plus ALA 600 once daily for 6 months."5.51Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients. ( Elshafiey, RA; Elzawawy, S; Ghoneim, A; Mostafa, TM; Werida, RH, 2022)
"To investigate the neurofunctional parameters in breast cancer (BC) patients with paclitaxel-induced peripheral neuropathy (PIPN) and to clarify the feasibility of using alpha-lipoic acid (ALA) in combination with the acetylcholinesterase inhibitor ipidacrine hydrochloride (IPD) for its prevention."5.51EFFECTIVENESS OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE IN PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ASSESSED BY ELECTRONEUROMYOGRAPHY OF SUPERFICIAL PERONEAL AND SURAL NERVES. ( Holotiuk, IS; Holotiuk, SI; Holotiuk, VV; Kryzhanivska, AY; Maliborska, SV, 2022)
" Lipoic acid alone or combined with paclitaxel can inhibit NF-κB expression and inhibit breast cancer cell proliferation."5.42Effect of lipoic acid combined with paclitaxel on breast cancer cells. ( Gong, Y; Hao, XY; Li, BJ; Ren, GH, 2015)
"Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes."5.17Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial. ( Botti, G; Brillante, G; Capasso, I; Cavalcanti, E; Ciliberto, G; Crispo, A; D'Aiuto, G; D'Aiuto, M; De Laurentiis, M; Esposito, E; Esposito, G; Frasci, G; Fucito, A; Grimaldi, M; Maurea, N; Montella, M, 2013)
" Motivated by the relatively high cytotoxic activity of gold complexes, such as Auranofin (approved to treat rheumatoid arthritis), for the treatment of various diseases, we anticipated that gold peptide bioconjugates would present interesting candidates for novel breast cancer therapies."3.91Bioconjugation of Cyclometalated Gold(III) Lipoic Acid Fragments to Linear and Cyclic Breast Cancer Targeting Peptides. ( Metzler-Nolte, N; Slootweg, JC; Śmiłowicz, D, 2019)
" In this study, we investigate secondary structure changes in the targeting protein Epidermal Growth Factor (EGF) during synthesis of theranostic bifunctional nanoparticle, devised for Photodynamic therapy of breast cancer."3.88FTIR study of secondary structure changes in Epidermal Growth Factor by gold nanoparticle conjugation. ( Bhattacharjee, TT; Castilho, ML; de Oliveira, IR; Hewitt, KC; Jesus, VPS; Raniero, L, 2018)
" Here, we report on reduction-sensitive reversibly crosslinked hyaluronic acid (HA) nanoparticles based on HA-Lys-LA conjugates (Lys: l-lysine methyl ester, LA: lipoic acid) for active targeting delivery of doxorubicin (DOX) to CD44+ breast cancers in vitro and in vivo, effectively overcoming drug resistance (ADR)."3.81Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts. ( Cheng, R; Deng, C; Meng, F; Xie, F; Zhang, J; Zhong, Y; Zhong, Z, 2015)
"Alopecia was evaluated by three independent reviewers using head photographs taken from four angles."2.90The utility of DHL-HisZnNa, a novel antioxidant, against anticancer agent-induced alopecia in breast cancer patients: a multicenter phase II clinical trial. ( Bando, H; Empuku, S; Hiratsuka, T; Inomata, M; Irie, Y; Ishida, M; Iwata, H; Kitano, S; Kondo, N; Kono, Y; Nakajima, K; Nishikawa, S; Ohno, S; Ohyama, T; Sagawa, N, 2019)
"In addition, DTX, a model drug for breast cancer treatment, was loaded (76."1.62A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases. ( Ji, J; Kong, X; Liu, D; Qiu, N; Xi, Y; Yang, X; Ye, L; Zhai, G; Zhang, J; Zhang, Y, 2021)
"Breast cancer is the second most common cancer in the world."1.56Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation. ( Farhat, D; Gadot, N; Ghayad, SE; Hussein, N; Icard, P; Le Romancer, M; Léon, S; Lincet, H, 2020)
"However, the effect of lipoic acid on breast cancer metastasis remains unclear."1.48α-Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGFβ signaling. ( Elangovan, S; Suar, M; Thangaraju, M; Tripathy, A; Tripathy, J, 2018)
"PTP1B and SHP2 are overexpressed in breast cancer cells, thus inhibition of their activity can be potentially effective in breast cancer therapy."1.46Lipoic Acid Decreases the Viability of Breast Cancer Cells and Activity of PTP1B and SHP2. ( Gorska-Ponikowska, M; Kuban-Jankowska, A; Wozniak, M, 2017)
" Lipoic acid alone or combined with paclitaxel can inhibit NF-κB expression and inhibit breast cancer cell proliferation."1.42Effect of lipoic acid combined with paclitaxel on breast cancer cells. ( Gong, Y; Hao, XY; Li, BJ; Ren, GH, 2015)
"MDA-MB-231 cells, a human breast cancer cell line, were treated with various concentrations of LA (0, 250, 500, or 1000 mumol/L) to measure metastasis, MMP activity, and mRNA expression."1.36alpha-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells. ( Kim, WK; Lee, HS; Na, MH, 2010)
"Stimulation of breast cancer growth and inhibition of intestinal tumours by LA indicate that diverse growth control mechanisms are modulated by LA in different organs."1.35Intestinal tumour chemoprevention with the antioxidant lipoic acid stimulates the growth of breast cancer. ( Alberti, S; Antolini, L; Di Lena, A; La Sorda, R; Lattanzio, R; Patassini, C; Piantelli, M; Rossi, C, 2008)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-19903 (10.00)18.7374
1990's0 (0.00)18.2507
2000's1 (3.33)29.6817
2010's17 (56.67)24.3611
2020's9 (30.00)2.80

Authors

AuthorsStudies
Qiu, N1
Yang, X1
Zhang, Y2
Zhang, J3
Ji, J1
Kong, X1
Xi, Y1
Liu, D1
Ye, L1
Zhai, G1
Holotiuk, IS2
Kryzhanivska, AY2
Holotiuk, SI2
Maliborska, SV2
Holotiuk, VV2
Werida, RH1
Elshafiey, RA1
Ghoneim, A1
Elzawawy, S1
Mostafa, TM1
Fang, H1
Zhao, X1
Gu, X1
Sun, H1
Cheng, R2
Zhong, Z3
Deng, C3
Śmiłowicz, D1
Slootweg, JC1
Metzler-Nolte, N1
Tripathy, J2
Chowdhury, AR1
Prusty, M1
Muduli, K1
Priyadarshini, N1
Reddy, KS1
Banerjee, B1
Elangovan, S2
Farhat, D2
Léon, S1
Ghayad, SE2
Gadot, N1
Icard, P2
Le Romancer, M2
Hussein, N2
Lincet, H2
Choi, HS1
Kim, JH1
Jang, SJ1
Yun, JW1
Kang, KM1
Jeong, H1
Ha, IB1
Jeong, BK1
Kuban-Jankowska, A1
Gorska-Ponikowska, M1
Wozniak, M1
Nur, G1
Nazıroğlu, M1
Deveci, HA1
Bhattacharjee, TT1
Castilho, ML1
de Oliveira, IR1
Jesus, VPS1
Hewitt, KC1
Raniero, L1
Tripathy, A1
Thangaraju, M1
Suar, M1
Yang, H1
Shen, W1
Liu, W1
Chen, L1
Zhang, P1
Xiao, C1
Chen, X1
Ling, L1
Ismail, M1
Du, Y1
Yao, C2
Li, X1
Sagawa, N1
Ohno, S1
Hiratsuka, T1
Kondo, N1
Iwata, H1
Bando, H1
Ohyama, T1
Ishida, M1
Kono, Y1
Nakajima, K1
Empuku, S1
Nishikawa, S1
Irie, Y1
Inomata, M1
Kitano, S1
Kothari, IR1
Mazumdar, S1
Sharma, S1
Italiya, K1
Mittal, A1
Chitkara, D1
Capasso, I1
Esposito, E1
Maurea, N1
Montella, M1
Crispo, A1
De Laurentiis, M1
D'Aiuto, M1
Frasci, G1
Botti, G1
Grimaldi, M1
Cavalcanti, E1
Esposito, G1
Fucito, A1
Brillante, G1
D'Aiuto, G1
Ciliberto, G1
Zhong, Y1
Meng, F2
Xie, F1
Li, BJ1
Hao, XY1
Ren, GH1
Gong, Y1
Hu, C1
Gu, F1
Tai, Z1
Gong, C1
Xia, Q1
Gao, Y1
Gao, S1
Sun, B1
Fahmy, UA1
Aljaeid, BM1
Rossi, C1
Di Lena, A1
La Sorda, R1
Lattanzio, R1
Antolini, L1
Patassini, C1
Piantelli, M1
Alberti, S1
Dozio, E1
Ruscica, M1
Passafaro, L1
Dogliotti, G1
Steffani, L1
Marthyn, P1
Pagani, A1
Demartini, G1
Esposti, D1
Fraschini, F1
Magni, P1
Lee, HS1
Na, MH1
Kim, WK1
Savvov, VI2
Karpov, LM2
Richardson, SG1
Killen, E1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Role of Alpha-Lipoic Acid Against Chemotherapy Induced Toxicities in Breast Cancer Patients[NCT03908528]64 participants (Actual)Interventional2019-03-01Completed
Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851]90 participants (Anticipated)Interventional2015-05-07Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for thioctic acid and Breast Cancer

ArticleYear
Lipoic acid-induced oxidative stress abrogates IGF-1R maturation by inhibiting the CREB/furin axis in breast cancer cell lines.
    Oncogene, 2020, Volume: 39, Issue:17

    Topics: Breast Neoplasms; Cyclic AMP Response Element-Binding Protein; Female; Furin; Humans; MCF-7 Cells; N

2020

Trials

5 trials available for thioctic acid and Breast Cancer

ArticleYear
EVALUATION OF THE EFFICIENCY OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE FOR THE PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ACCORDING TO THE TOTAL NEUROPATHY SCORE.
    Experimental oncology, 2022, Volume: 44, Issue:1

    Topics: Acetylcholinesterase; Aminoquinolines; Breast Neoplasms; Cholinesterase Inhibitors; Female; Humans;

2022
Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients.
    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022, Volume: 30, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cardiotoxicity; Doxorubicin; Femal

2022
EFFECTIVENESS OF ALPHA-LIPOIC ACID AND IPIDACRINE HYDROCHLORIDE IN PREVENTION OF PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY ASSESSED BY ELECTRONEUROMYOGRAPHY OF SUPERFICIAL PERONEAL AND SURAL NERVES.
    Experimental oncology, 2022, Volume: 44, Issue:4

    Topics: Acetylcholinesterase; Breast Neoplasms; Female; Humans; Paclitaxel; Peripheral Nervous System Diseas

2022
The utility of DHL-HisZnNa, a novel antioxidant, against anticancer agent-induced alopecia in breast cancer patients: a multicenter phase II clinical trial.
    Breast cancer research and treatment, 2019, Volume: 176, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Alopecia; Antineoplastic Agents; Antioxidants; Breast Neoplasms; Com

2019
Combination of inositol and alpha lipoic acid in metabolic syndrome-affected women: a randomized placebo-controlled trial.
    Trials, 2013, Aug-28, Volume: 14

    Topics: Aged; Biomarkers; Blood Glucose; Body Mass Index; Breast Neoplasms; Caloric Restriction; Cholesterol

2013

Other Studies

24 other studies available for thioctic acid and Breast Cancer

ArticleYear
A molybdenum oxide-based degradable nanosheet for combined chemo-photothermal therapy to improve tumor immunosuppression and suppress distant tumors and lung metastases.
    Journal of nanobiotechnology, 2021, Dec-19, Volume: 19, Issue:1

    Topics: Animals; Biocompatible Materials; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Doxorubicin; Fe

2021
CD44-Targeted Multifunctional Nanomedicines Based on a Single-Component Hyaluronic Acid Conjugate with All-Natural Precursors: Construction and Treatment of Metastatic Breast Tumors
    Biomacromolecules, 2020, 01-13, Volume: 21, Issue:1

    Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Docetaxel; Drug Carriers; Drug Delivery Systems; F

2020
Bioconjugation of Cyclometalated Gold(III) Lipoic Acid Fragments to Linear and Cyclic Breast Cancer Targeting Peptides.
    Molecular pharmaceutics, 2019, 11-04, Volume: 16, Issue:11

    Topics: Antineoplastic Agents; Auranofin; Breast Neoplasms; Cell Line, Tumor; Cisplatin; Coordination Comple

2019
α-Lipoic acid prevents the ionizing radiation-induced epithelial-mesenchymal transition and enhances the radiosensitivity in breast cancer cells.
    European journal of pharmacology, 2020, Mar-15, Volume: 871

    Topics: Breast Neoplasms; Cell Movement; Epithelial-Mesenchymal Transition; Humans; Matrix Metalloproteinase

2020
Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation.
    British journal of cancer, 2020, Volume: 122, Issue:6

    Topics: Breast Neoplasms; Cell Proliferation; Down-Regulation; Female; Furin; Humans; Receptor, IGF Type 1;

2020
Synergistic Tumoricidal Effects of Alpha-Lipoic Acid and Radiotherapy on Human Breast Cancer Cells via HMGB1.
    Cancer research and treatment, 2021, Volume: 53, Issue:3

    Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cellular Senescence; Chemoradiotherapy

2021
Lipoic Acid Decreases the Viability of Breast Cancer Cells and Activity of PTP1B and SHP2.
    Anticancer research, 2017, Volume: 37, Issue:6

    Topics: Antineoplastic Agents; Antioxidants; Breast Neoplasms; Cell Survival; Humans; Leukocyte Common Antig

2017
Synergic prooxidant, apoptotic and TRPV1 channel activator effects of alpha-lipoic acid and cisplatin in MCF-7 breast cancer cells.
    Journal of receptor and signal transduction research, 2017, Volume: 37, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Apoptosis; Breast Neoplasms; Cell Surv

2017
FTIR study of secondary structure changes in Epidermal Growth Factor by gold nanoparticle conjugation.
    Biochimica et biophysica acta. General subjects, 2018, Volume: 1862, Issue:3

    Topics: Breast Neoplasms; Cell Line, Tumor; Chlorophyllides; Epidermal Growth Factor; ErbB Receptors; Female

2018
α-Lipoic acid inhibits the migration and invasion of breast cancer cells through inhibition of TGFβ signaling.
    Life sciences, 2018, Aug-15, Volume: 207

    Topics: Active Transport, Cell Nucleus; Angiopoietin-Like Protein 4; Animals; Breast Neoplasms; Cell Line, T

2018
PEGylated Poly(α-lipoic acid) Loaded with Doxorubicin as a pH and Reduction Dual Responsive Nanomedicine for Breast Cancer Therapy.
    Biomacromolecules, 2018, 11-12, Volume: 19, Issue:11

    Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Breast Neoplasms; Doxorubicin; Drug Delivery Sys

2018
Lipoic acid-derived cross-linked liposomes for reduction-responsive delivery of anticancer drug.
    International journal of pharmaceutics, 2019, Apr-05, Volume: 560

    Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Cell Proliferation; Cell Survival; Cross-Lin

2019
Docetaxel and alpha-lipoic acid co-loaded nanoparticles for cancer therapy.
    Therapeutic delivery, 2019, Volume: 10, Issue:4

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Docet

2019
Reversibly crosslinked hyaluronic acid nanoparticles for active targeting and intelligent delivery of doxorubicin to drug resistant CD44+ human breast tumor xenografts.
    Journal of controlled release : official journal of the Controlled Release Society, 2015, May-10, Volume: 205

    Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Chemistry, Pharmaceutical; Cross-Linking Rea

2015
Effect of lipoic acid combined with paclitaxel on breast cancer cells.
    Genetics and molecular research : GMR, 2015, Dec-22, Volume: 14, Issue:4

    Topics: Apoptosis; Breast Neoplasms; Cell Proliferation; Female; Humans; MCF-7 Cells; NF-kappa B; Paclitaxel

2015
Synergistic effect of reduced polypeptide micelle for co-delivery of doxorubicin and TRAIL against drug-resistance in breast cancer.
    Oncotarget, 2016, Sep-20, Volume: 7, Issue:38

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Line, Tum

2016
Robust, active tumor-targeting and fast bioresponsive anticancer nanotherapeutics based on natural endogenous materials.
    Acta biomaterialia, 2016, Volume: 45

    Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Breast Neoplasms; Cross-Linking Reagents; D

2016
Combined strategy for suppressing breast carcinoma MCF-7 cell lines by loading simvastatin on alpha lipoic acid nanoparticles.
    Expert opinion on drug delivery, 2016, Volume: 13, Issue:12

    Topics: Apoptosis; Breast Neoplasms; Cell Survival; Female; Humans; MCF-7 Cells; Nanoparticles; Particle Siz

2016
Intestinal tumour chemoprevention with the antioxidant lipoic acid stimulates the growth of breast cancer.
    European journal of cancer (Oxford, England : 1990), 2008, Volume: 44, Issue:17

    Topics: Analysis of Variance; Animals; Antineoplastic Agents; Antioxidants; Breast Neoplasms; Female; Intest

2008
The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells.
    European journal of pharmacology, 2010, Sep-01, Volume: 641, Issue:1

    Topics: Antioxidants; Apoptosis; Biological Products; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell P

2010
alpha-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells.
    Nutrition research (New York, N.Y.), 2010, Volume: 30, Issue:6

    Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Breast Neoplasms; Cell Line, Tumor; Cell Movement;

2010
[Characteristics of 35S-lipoic acid absorption by the blood cells in breast cancer].
    Voprosy onkologii, 1982, Volume: 28, Issue:7

    Topics: Absorption; Acute Disease; Adenocarcinoma, Scirrhous; Adenofibroma; Breast Neoplasms; Erythrocytes;

1982
Metabolism of oestradiol by human mammary tumour 800 x g supernatants pretreated with dihydrolipoic acid.
    Cancer letters, 1977, Volume: 2, Issue:4-5

    Topics: Breast Neoplasms; Estradiol; Humans; Thioctic Acid; Tritium

1977
[Pyruvate oxidation and S35-lipoic acid fixation by breast tumor homogenates].
    Voprosy onkologii, 1978, Volume: 24, Issue:8

    Topics: Adenocarcinoma, Scirrhous; Adenofibroma; Breast Neoplasms; Female; Humans; In Vitro Techniques; Oxid

1978