thioctic acid has been researched along with Brain Ischemia in 23 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Experimental and clinical suppositions of the use of a-lipoic acid as one of the most studied antioxidant in the treatment of brain ischemia as well as the results of own studies on the preparation berlition which contains a-lipoic acid used in the neuroprotective therapy of chronic brain ischemia for correction of free-radical processes are discussed." | 5.13 | [The free-radical processes and antioxidant therapy in brain ischemia]. ( Aseĭchev, AV; Azizova, OA; Baranova, OA; Bekman, EM; Fedin, AI; Mironova, OP; Solov'eva, EIu, 2008) |
| "The effect of original domestic derivatives of 3-oxypiridine and succinic acid (emoxipine, reamberin and mexidol) on the resistance to acute brain ischemia was studied in an experimental mouse models." | 3.80 | [The effect of 3-oxypyridine and succinic acid derivatives on the resistance to acute cerebral ischemia]. ( Faĭzullin, RM; Kalugina, AV; Malkin, MP; Miroshnichenko, II; Priakhina, KE; Rassokhina, LM; Volchegorskiĭ, IA, 2014) |
| "We studied the effect of deproteinized hemoderivative of calf blood, thioctic acid and vinpocetine with piracetam on the endothelial function in patients with chronic cerebral ischemia stage III." | 3.79 | [Pharmacotherapy of endothelial dysfunction in patients with atherosclerotic brain ischemia]. ( Abdrakhmanova, EK; Fedin, AI; Mironova, OP; Parfenov, AS; Starykh, EP; Starykh, EV, 2013) |
| "alpha-Lipoic acid (thioctic acid) was tested for its neuroprotective activity in a Mongolian gerbil model of forebrain ischemia/reperfusion." | 3.69 | The free radical scavenger, alpha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils. ( Cao, X; Phillis, JW, 1995) |
| " Both α-lipoic acid and etanercept markedly reduced cerebral infarct, blood-brain barrier disruption, and neurological motor deficits with the former drug being more effective with the dosage used." | 1.43 | Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke. ( Chang, CP; Chio, CC; Huang, CC; Lin, MT; Lin, NK; Tsai, KJ; Wu, MH, 2016) |
| "We used the models of focal cerebral ischemia in mice and rats." | 1.29 | Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia. ( Krieglstein, J; Wolz, P, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 14 (60.87) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, X | 1 |
| Chen, W | 1 |
| Li, J | 1 |
| Shen, C | 1 |
| Zhou, P | 1 |
| Che, X | 1 |
| Li, X | 1 |
| Xie, R | 1 |
| Zhang, J | 3 |
| Xiao, F | 1 |
| Zhang, L | 1 |
| Wang, X | 2 |
| Lai, X | 1 |
| Shen, Y | 1 |
| Zhang, M | 1 |
| Zhou, B | 1 |
| Lang, H | 1 |
| Yu, P | 1 |
| Hua, F | 1 |
| Fedin, AI | 3 |
| Starykh, EP | 1 |
| Parfenov, AS | 1 |
| Mironova, OP | 3 |
| Abdrakhmanova, EK | 1 |
| Starykh, EV | 1 |
| Connell, BJ | 5 |
| Saleh, MC | 3 |
| Kucukkaya, I | 2 |
| Abd-El-Aziz, AS | 2 |
| Khan, BV | 3 |
| Saleh, TM | 5 |
| Rajagopal, D | 2 |
| Fu, B | 1 |
| Zhang, X | 1 |
| Zhang, C | 1 |
| Li, Y | 1 |
| Zhang, Y | 2 |
| He, T | 1 |
| Li, P | 1 |
| Zhu, X | 1 |
| Zhao, Y | 1 |
| Deng, H | 1 |
| Zuo, X | 1 |
| Liu, X | 1 |
| Liu, L | 1 |
| Xu, Q | 1 |
| Wu, Z | 1 |
| Ji, A | 1 |
| Volchegorskiĭ, IA | 1 |
| Miroshnichenko, II | 1 |
| Rassokhina, LM | 1 |
| Faĭzullin, RM | 1 |
| Priakhina, KE | 1 |
| Malkin, MP | 1 |
| Kalugina, AV | 1 |
| Wu, MH | 1 |
| Huang, CC | 1 |
| Chio, CC | 1 |
| Tsai, KJ | 1 |
| Chang, CP | 1 |
| Lin, NK | 1 |
| Lin, MT | 1 |
| Solov'eva, EIu | 2 |
| Baranova, OA | 2 |
| Bekman, EM | 1 |
| Aseĭchev, AV | 1 |
| Azizova, OA | 1 |
| Saleh, M | 1 |
| Röhnert, P | 1 |
| Schröder, UH | 1 |
| Ziabreva, I | 1 |
| Täger, M | 1 |
| Reymann, KG | 1 |
| Striggow, F | 1 |
| Chekanov, AV | 1 |
| Karneev, AN | 1 |
| Miachin, IV | 1 |
| Panasenko, OM | 1 |
| do Vale, OC | 1 |
| Fonteles, DS | 1 |
| Cabral, FR | 1 |
| Fonteles, MC | 1 |
| Iksanova, GR | 1 |
| Saĭfullina, EI | 1 |
| Kolchina, EM | 1 |
| Novikova, LB | 1 |
| Cao, X | 1 |
| Phillis, JW | 1 |
| Panigrahi, M | 1 |
| Sadguna, Y | 1 |
| Shivakumar, BR | 1 |
| Kolluri, SV | 1 |
| Roy, S | 2 |
| Packer, L | 2 |
| Ravindranath, V | 1 |
| Wolz, P | 1 |
| Krieglstein, J | 2 |
| Gohil, K | 1 |
| Sen, CK | 1 |
| Piotrowski, P | 1 |
| Wierzbicka, K | 1 |
| Smiałek, M | 1 |
| Prehn, JH | 1 |
| Karkoutly, C | 1 |
| Nuglisch, J | 1 |
| Peruche, B | 1 |
1 trial available for thioctic acid and Brain Ischemia
| Article | Year |
|---|---|
[The free-radical processes and antioxidant therapy in brain ischemia].
Topics: Aged; Antioxidants; Brain Ischemia; Drug Administration Schedule; Female; Free Radicals; Humans; Mal | 2008 |
22 other studies available for thioctic acid and Brain Ischemia
| Article | Year |
|---|---|
The protective effect of alpha-lipoic acid against brain ischemia and reperfusion injury via mTOR signaling pathway in rats.
Topics: Animals; Brain Ischemia; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reperfusion Injur | 2018 |
Alpha-Lipoic Acid Preconditioning and Ischaemic Postconditioning Synergistically Protect Rats from Cerebral Injury Induced by Ischemia and Reperfusion Partly via Inhibition TLR4/MyD88/ NF-κB Signaling Pathway.
Topics: Animals; Anti-Inflammatory Agents; Brain; Brain Ischemia; Ischemic Postconditioning; Male; Myeloid D | 2018 |
[Pharmacotherapy of endothelial dysfunction in patients with atherosclerotic brain ischemia].
Topics: Aged; Aged, 80 and over; Antioxidants; Brain Ischemia; Calcium Channel Blockers; Endothelium, Vascul | 2013 |
UPEI-300, a conjugate of lipoic acid and edaravone, mediates neuroprotection in ischemia/reperfusion.
Topics: Animals; Antipyrine; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Drug Combinations; Male; Neocort | 2014 |
Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Humans; Male; Rats; Rats, Sprague-Daw | 2014 |
Alpha-lipoic acid upregulates SIRT1-dependent PGC-1α expression and protects mouse brain against focal ischemia.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; M | 2014 |
Α‑lipoic acid protects against cerebral ischemia/reperfusion-induced injury in rats.
Topics: Animals; Antioxidants; Apoptosis; Brain Edema; Brain Ischemia; Brain-Derived Neurotrophic Factor; Ca | 2015 |
[The effect of 3-oxypyridine and succinic acid derivatives on the resistance to acute cerebral ischemia].
Topics: Acute Disease; Animals; Brain Ischemia; Disease Models, Animal; Female; Male; Meglumine; Mice; Picol | 2014 |
Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Dose-Response Relationship, Drug; Down-Regulation; Dru | 2016 |
UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Sprague-D | 2017 |
Lipoic acid protects against reperfusion injury in the early stages of cerebral ischemia.
Topics: Animals; Antioxidants; Baroreflex; Blotting, Western; Brain Ischemia; Cerebral Infarction; Cerebrova | 2011 |
Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion.
Topics: Animals; Brain Ischemia; Cell Death; Disease Models, Animal; Ethidium; Fluoresceins; Gerbillinae; Gl | 2012 |
Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion.
Topics: Acetophenones; Animals; Brain; Brain Ischemia; Drug Combinations; Humans; Male; Neuroprotective Agen | 2012 |
[A search for new markers of oxidative stress in brain ischemia for the optimization of treatment approaches].
Topics: Aged; Antioxidants; Biomarkers; Brain Ischemia; Female; Humans; Lipid Peroxidation; Male; Middle Age | 2011 |
A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Dr | 2003 |
[Assessment of berlition effectiveness in ischemic stroke with CT perfusion imaging of the brain].
Topics: Adult; Brain; Brain Ischemia; Cerebrovascular Circulation; Female; Humans; Male; Middle Aged; Thioct | 2008 |
The free radical scavenger, alpha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils.
Topics: Animals; Brain Ischemia; Free Radical Scavengers; Gerbillinae; Locomotion; Reperfusion Injury; Thioc | 1995 |
alpha-Lipoic acid protects against reperfusion injury following cerebral ischemia in rats.
Topics: Animals; Antioxidants; Brain Chemistry; Brain Ischemia; Glutathione; Injections, Intravenous; Male; | 1996 |
Neuroprotective effects of alpha-lipoic acid and its enantiomers demonstrated in rodent models of focal cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Hemodynamics; Male; Mice; Rats; Rats, Sprague-D | 1996 |
Antioxidant regulation of gene expression: analysis of differentially expressed mRNAs.
Topics: Animals; Antioxidants; Brain Ischemia; Cerebellum; Cloning, Molecular; DNA, Complementary; Flavonoid | 1999 |
Neuronal death in the rat hippocampus in experimental diabetes and cerebral ischaemia treated with antioxidants.
Topics: Animals; Antioxidants; Apoptosis; Blood Glucose; Brain Ischemia; Caspase 3; Caspases; Cell Count; Co | 2001 |
Dihydrolipoate reduces neuronal injury after cerebral ischemia.
Topics: Animals; Blood Glucose; Blood Pressure; Body Temperature; Brain; Brain Ischemia; Glutamates; Glutami | 1992 |