thioctic acid has been researched along with Blood Poisoning in 15 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis is a life-threatening immune disorder resulting from an dysregulated host response to infection." | 3.30 | Adjuvant Lipoic acid Injection in Sepsis treatment in China (ALIS study): protocol for a randomised, single-blind, placebo-controlled trial. ( Chen, C; Chen, X; He, Y; Hu, L; Huang, J; Huang, X; Li, S; Wang, G; Wu, K; Wu, Q; Zhou, X, 2023) |
| "Sepsis is a complication of an infection which imbalance the normal regulation of several organ systems, including the central nervous system (CNS)." | 1.46 | Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis. ( Barichello, T; Bellettini-Santos, T; Budni, J; da Rosa, N; Dal-Pizzol, F; Danielski, LG; Della Giustina, A; Fileti, ME; Florentino, D; Fortunato, JJ; Garbossa, L; Goldim, MP; Martins Laurentino, AO; Mathias, K; Mina, F; Oliveira Junior, AN; Petronilho, F; Zarbato, GF, 2017) |
| "Sepsis is often initiated by invasive infection, characterized by overwhelming induction of pro-inflammatory cytokines." | 1.42 | Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. ( Fu, J; Ji, K; Li, G; Luan, T; Zang, B; Zhao, Y, 2015) |
| "Acute kidney injury is a frequent and serious complication in patients with severe sepsis." | 1.40 | α-Lipoic acid prolongs survival and attenuates acute kidney injury in a rat model of sepsis. ( Chen, W; Gao, L; Gong, X; Jia, J; Li, G; Zang, B, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 9 (60.00) | 24.3611 |
| 2020's | 3 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hu, L | 1 |
| Zhou, X | 1 |
| Huang, J | 1 |
| He, Y | 1 |
| Wu, Q | 1 |
| Huang, X | 1 |
| Wu, K | 1 |
| Wang, G | 1 |
| Li, S | 1 |
| Chen, X | 1 |
| Chen, C | 1 |
| Giustina, AD | 1 |
| de Souza Goldim, MP | 1 |
| Danielski, LG | 3 |
| Garbossa, L | 2 |
| Junior, ANO | 1 |
| Cidreira, T | 1 |
| Denicol, T | 1 |
| Bonfante, S | 2 |
| da Rosa, N | 2 |
| Fortunato, JJ | 2 |
| Palandi, J | 1 |
| de Oliveira, BH | 1 |
| Martins, DF | 1 |
| Bobinski, F | 1 |
| Garcez, M | 1 |
| Bellettini-Santos, T | 2 |
| Budni, J | 2 |
| Colpo, G | 1 |
| Scaini, G | 1 |
| Giridharan, VV | 1 |
| Barichello, T | 2 |
| Petronilho, F | 3 |
| Pagano, G | 1 |
| Manfredi, C | 1 |
| Pallardó, FV | 1 |
| Lyakhovich, A | 1 |
| Tiano, L | 1 |
| Trifuoggi, M | 1 |
| Della Giustina, A | 1 |
| Goldim, MP | 2 |
| Florentino, D | 2 |
| Mathias, K | 1 |
| Oliveira Junior, AN | 1 |
| Fileti, ME | 1 |
| Zarbato, GF | 1 |
| Martins Laurentino, AO | 1 |
| Mina, F | 1 |
| Dal-Pizzol, F | 1 |
| Jia, J | 2 |
| Gong, X | 2 |
| Zhao, Y | 2 |
| Yang, Z | 1 |
| Ji, K | 2 |
| Luan, T | 2 |
| Zang, B | 3 |
| Li, G | 3 |
| Hiller, S | 1 |
| DeKroon, R | 1 |
| Xu, L | 2 |
| Robinette, J | 1 |
| Winnik, W | 1 |
| Alzate, O | 1 |
| Simington, S | 1 |
| Maeda, N | 2 |
| Yi, X | 2 |
| Gao, L | 1 |
| Chen, W | 1 |
| Fu, J | 1 |
| Shen, HH | 1 |
| Lam, KK | 1 |
| Cheng, PY | 1 |
| Kung, CW | 1 |
| Chen, SY | 1 |
| Lin, PC | 1 |
| Chung, MT | 1 |
| Lee, YM | 1 |
| Vieira, LC | 1 |
| Martins, MM | 1 |
| Vieira, A | 1 |
| Vuolo, F | 1 |
| Zorzoli, A | 1 |
| Grayczyk, JP | 1 |
| Alonzo, F | 1 |
| Kim, K | 1 |
| Yuan, W | 1 |
| Kim, HS | 1 |
| Homeister, JW | 1 |
| Key, NS | 1 |
| Vanasco, V | 1 |
| Cimolai, MC | 1 |
| Evelson, P | 1 |
| Alvarez, S | 1 |
| Cadirci, E | 1 |
| Altunkaynak, BZ | 1 |
| Halici, Z | 1 |
| Odabasoglu, F | 1 |
| Uyanik, MH | 1 |
| Gundogdu, C | 1 |
| Suleyman, H | 1 |
| Halici, M | 1 |
| Albayrak, M | 1 |
| Unal, B | 1 |
| Zhang, WJ | 1 |
| Wei, H | 1 |
| Hagen, T | 1 |
| Frei, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thioctic acid and Blood Poisoning
| Article | Year |
|---|---|
Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumonia.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carnitine; Chemotherapy, Adjuvant; COVID-19 Drug T | 2021 |
1 trial available for thioctic acid and Blood Poisoning
| Article | Year |
|---|---|
Adjuvant Lipoic acid Injection in Sepsis treatment in China (ALIS study): protocol for a randomised, single-blind, placebo-controlled trial.
Topics: Humans; Intensive Care Units; Prognosis; Randomized Controlled Trials as Topic; Sepsis; Single-Blind | 2023 |
13 other studies available for thioctic acid and Blood Poisoning
| Article | Year |
|---|---|
Lipoic Acid and Fish Oil Combination Potentiates Neuroinflammation and Oxidative Stress Regulation and Prevents Cognitive Decline of Rats After Sepsis.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Catalase; Cells, Cultured; Cognitive Dysfunction; | 2020 |
Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis.
Topics: Acute Disease; Animals; Antioxidants; Brain; Cognitive Dysfunction; Coinfection; Inflammation; Infla | 2017 |
Autophagy Enhancing Contributes to the Organ Protective Effect of Alpha-Lipoic Acid in Septic Rats.
Topics: Animals; Apoptosis; Autophagy; Cytokines; Disease Models, Animal; Inflammation; Male; NF-kappa B; Pr | 2019 |
α-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice.
Topics: Adenosine Triphosphate; Animals; Antioxidants; Electron Transport Complex III; Energy Metabolism; Fe | 2014 |
α-Lipoic acid prolongs survival and attenuates acute kidney injury in a rat model of sepsis.
Topics: Acute Kidney Injury; Animals; Antioxidants; Cecum; Ligation; Male; NF-kappa B; Punctures; Rats; Rats | 2014 |
Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Cel | 2015 |
Alpha-lipoic acid prevents endotoxic shock and multiple organ dysfunction syndrome induced by endotoxemia in rats.
Topics: Animals; Antioxidants; Antithrombins; Aorta; Caspase 3; Disulfides; Endotoxemia; Enzyme Activation; | 2015 |
Alpha-Lipoic Acid Attenuates Oxidative Damage in Organs After Sepsis.
Topics: Animals; Antioxidants; Catalase; Cecum; Inflammation; Kidney; Lipid Peroxidation; Liver; Lung; Male; | 2016 |
Staphylococcus aureus Tissue Infection During Sepsis Is Supported by Differential Use of Bacterial or Host-Derived Lipoic Acid.
Topics: Adaptation, Physiological; Animals; Disease Models, Animal; Female; Mice; Mutagenesis, Site-Directed | 2016 |
Mice with heterozygous deficiency of lipoic acid synthase have an increased sensitivity to lipopolysaccharide-induced tissue injury.
Topics: Animals; Cytokines; E-Selectin; Energy Metabolism; Heterozygote; Lipopolysaccharides; Liver; Lung; M | 2009 |
The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by alpha-lipoic acid.
Topics: Animals; Antioxidants; Endotoxemia; Female; Lipopolysaccharides; Mitochondria; Muscle, Skeletal; Nit | 2008 |
Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats.
Topics: Acute Lung Injury; Animals; Cecum; Disease Models, Animal; Interleukin-6; Ligation; Male; NF-kappa B | 2010 |
Alpha-lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line, Tumor; Humans; Inflammation; Lipopolysac | 2007 |