Page last updated: 2024-10-19

thioctic acid and Autoimmune Disease

thioctic acid has been researched along with Autoimmune Disease in 21 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Research Excerpts

ExcerptRelevanceReference
"Primary biliary cirrhosis is an enigmatic autoimmune disease of women characterized by antimitochondrial antibodies and destruction of intrahepatic bile ducts."2.41Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics. ( Gershwin, ME; Long, SA; Van de Water, J, 2002)
"Primary biliary cirrhosis (PBC) is associated with a high incidence of autoantibodies directed at mitochondrial autoantigens (the antimito-chondrial antibodies), identified as the E2 components of PDC, OGDC, and BCOADC, together with protein X and the E1 alpha and E1 beta subunits of PDC."2.40Biochemistry and autoimmune response to the 2-oxoacid dehydrogenase complexes in primary biliary cirrhosis. ( Bassendine, MF; Jones, DE; Yeaman, SJ, 1997)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (14.29)18.2507
2000's8 (38.10)29.6817
2010's5 (23.81)24.3611
2020's5 (23.81)2.80

Authors

AuthorsStudies
Capece, U1
Moffa, S2
Improta, I2
Di Giuseppe, G1
Nista, EC1
Cefalo, CMA1
Cinti, F1
Pontecorvi, A1
Gasbarrini, A1
Giaccari, A2
Mezza, T2
Comhaire, F1
Deslypere, JP1
Lu, Y1
Li, W1
Li, Y1
Lian, X1
Gullo, D2
Magliozzo, M1
Strano, A1
Piazza, VG1
Stabile, G1
Belfiore, A1
Li, Z1
Su, Y1
Yi, D1
Wu, C1
Fang, W1
Wang, C1
Rocchetti, S1
Liu, W1
Shi, LJ1
Li, SG1
Evans, JL1
Sortino, G1
Goldfine, ID1
Vigneri, R1
Michalopoulou Alevras, T1
Guerrero Gual, M1
Villabona Artero, C1
Pérez-Maraver, M1
Uchigata, Y2
Hirata, Y1
Iwamoto, Y1
Bresciani, E1
Bussi, A1
Bazzigaluppi, E1
Balestrieri, G1
Long, SA1
Van de Water, J1
Gershwin, ME3
Padgett, KA1
Selmi, C1
Kenny, TP1
Leung, PS2
Balkwill, DL1
Ansari, AA1
Coppel, RL2
Furukawa, N1
Miyamura, N1
Nishida, K1
Motoshima, H1
Taketa, K1
Araki, E1
Takeuchi, Y1
Miyamoto, T1
Kakizawa, T1
Shigematsu, S1
Hashizume, K1
Ishida, Y1
Ohara, T1
Okuno, Y1
Ito, T1
Hirota, Y1
Furukawa, K1
Sakaguchi, K1
Ogawa, W1
Kasuga, M1
Yamada, T1
Imai, J1
Ishigaki, Y1
Hinokio, Y1
Oka, Y1
Katagiri, H1
Christen, U1
Quinn, J1
Yeaman, SJ2
Kenna, JG1
Clarke, JB1
Gandolfi, AJ1
Gut, J1
Bassendine, MF1
Jones, DE1
Ansari, A1
Munoz, S1

Reviews

6 reviews available for thioctic acid and Autoimmune Disease

ArticleYear
Alpha-Lipoic Acid and Glucose Metabolism: A Comprehensive Update on Biochemical and Therapeutic Features.
    Nutrients, 2022, Dec-21, Volume: 15, Issue:1

    Topics: Antioxidants; Autoimmune Diseases; Diabetic Neuropathies; Female; Glucose; Humans; Insulin Resistanc

2022
[Clinical Characteristics of Lipoic Acid-mediated Insulin Autoimmune Syndrome in Two Patients with Type 2 Diabetes Mellitus].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2020, Volume: 42, Issue:5

    Topics: Autoimmune Diseases; Diabetes Mellitus, Type 2; Humans; Thioctic Acid

2020
The Immunomodulatory Effect of Alpha-Lipoic Acid in Autoimmune Diseases.
    BioMed research international, 2019, Volume: 2019

    Topics: Animals; Antioxidants; Autoimmune Diseases; Humans; Immunologic Factors; Thioctic Acid

2019
Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics.
    Autoimmunity reviews, 2002, Volume: 1, Issue:1-2

    Topics: Animals; Autoantibodies; Autoimmune Diseases; Bile Ducts, Intrahepatic; Female; Humans; Inflammation

2002
Biochemistry and autoimmune response to the 2-oxoacid dehydrogenase complexes in primary biliary cirrhosis.
    Seminars in liver disease, 1997, Volume: 17, Issue:1

    Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Antigen-Antibody Reactions; Autoantibodies; Autoa

1997
Antimitochondrial antibodies in primary biliary cirrhosis.
    Seminars in liver disease, 1997, Volume: 17, Issue:1

    Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Autoantibodies; Autoantigens; Autoimmune Diseases

1997

Trials

1 trial available for thioctic acid and Autoimmune Disease

ArticleYear
News and views in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): The role of co-morbidity and novel treatments.
    Medical hypotheses, 2020, Volume: 134

    Topics: Adult; Animals; Antiviral Agents; Autoimmune Diseases; Comorbidity; Dichloroacetic Acid; Dietary Sup

2020

Other Studies

14 other studies available for thioctic acid and Autoimmune Disease

ArticleYear
Insulin autoimmune syndrome misdiagnosed as an insulinoma in a woman presenting with a pancreatic cystic lesion and taking alpha lipoic acid: a lesson to be learned.
    Hormones (Athens, Greece), 2021, Volume: 20, Issue:3

    Topics: Autoimmune Diseases; Diagnostic Errors; Female; Humans; Hyperinsulinism; Insulinoma; Insulins; Pancr

2021
Analysis of the clinical characteristics of insulin autoimmune syndrome induced by alpha-lipoic acid.
    Journal of clinical pharmacy and therapeutics, 2021, Volume: 46, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Autoantibodies; Autoimmune Diseases; Blood Glucose; C-Peptide; Femal

2021
Potential cause-effect relationship between insulin autoimmune syndrome and alpha lipoic acid: Two case reports.
    Nutrition (Burbank, Los Angeles County, Calif.), 2019, Volume: 57

    Topics: Aged; Aged, 80 and over; Antioxidants; Autoimmune Diseases; Dietary Supplements; Female; Glucocortic

2019
Insulin autoimmune syndrome (Hirata Disease) in European Caucasians taking α-lipoic acid.
    Clinical endocrinology, 2014, Volume: 81, Issue:2

    Topics: Aged; Autoimmune Diseases; Europe; Female; Glucose; HLA-DRB1 Chains; Humans; Male; Middle Aged; Pred

2014
[Autoimmune hypoglycemia syndrome associated with α lipoic acid consumption].
    Medicina clinica, 2015, Jan-20, Volume: 144, Issue:2

    Topics: Alopecia; Antioxidants; Autoimmune Diseases; Cystine; Diagnosis, Differential; Dietary Supplements;

2015
Drug-induced insulin autoimmune syndrome.
    Diabetes research and clinical practice, 2009, Volume: 83, Issue:1

    Topics: Autoimmune Diseases; Dietary Supplements; Humans; Hypoglycemia; Insulin; Methimazole; Thioctic Acid

2009
Insulin autoimmune syndrome induced by α-lipoic acid in a Caucasian woman: case report.
    Diabetes care, 2011, Volume: 34, Issue:9

    Topics: Aged; Autoimmune Diseases; Female; Humans; Thioctic Acid

2011
Phylogenetic and immunological definition of four lipoylated proteins from Novosphingobium aromaticivorans, implications for primary biliary cirrhosis.
    Journal of autoimmunity, 2005, Volume: 24, Issue:3

    Topics: Acyltransferases; Amino Acid Sequence; Animals; Antigens, Bacterial; Autoantigens; Autoimmune Diseas

2005
Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome.
    Diabetes research and clinical practice, 2007, Volume: 75, Issue:3

    Topics: Adult; Autoimmune Diseases; Blood Glucose; Dietary Supplements; Female; HLA-DR Antigens; HLA-DRB1 Ch

2007
Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid.
    Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:5

    Topics: Autoantibodies; Autoimmune Diseases; Blood Glucose; Genotype; HLA-DR Antigens; HLA-DRB1 Chains; Huma

2007
Alpha-lipoic acid and insulin autoimmune syndrome.
    Diabetes care, 2007, Volume: 30, Issue:9

    Topics: Adult; Antioxidants; Autoantibodies; Autoimmune Diseases; Female; Genetic Predisposition to Disease;

2007
The novel agent, alpha lipoic acid, can cause the development of insulin autoimmune syndrome.
    Internal medicine (Tokyo, Japan), 2007, Volume: 46, Issue:17

    Topics: Antioxidants; Autoantibodies; Autoimmune Diseases; Humans; Hypoglycemia; Insulin; Thioctic Acid

2007
Possible relevance of HLA-DRB1*0403 haplotype in insulin autoimmune syndrome induced by alpha-lipoic acid, used as a dietary supplement.
    Diabetes care, 2007, Volume: 30, Issue:12

    Topics: Autoimmune Diseases; Dietary Supplements; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Insulin; Thiocti

2007
Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid.
    European journal of biochemistry, 1994, Aug-01, Volume: 223, Issue:3

    Topics: Acetyltransferases; Amino Acid Sequence; Autoantigens; Autoimmune Diseases; Binding, Competitive; Ch

1994