thioctic acid has been researched along with Autoimmune Diabetes in 33 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Type 1 diabetes is associated with increased platelet reactivity." | 2.77 | Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients. ( Crea, F; Ghirlanda, G; Lanza, GA; Manto, A; Mollo, R; Navarese, EP; Pitocco, D; Rizzo, P; Scalone, G; Scavone, G; Zaccardi, F, 2012) |
| "A daily dosage of 600 mg ALA does not prevent the occurrence of CSME in IDDM patients." | 2.76 | Alpha-lipoic acid for the prevention of diabetic macular edema. ( Gerss, J; Hammes, HP; Haritoglou, C; Kampik, A; Ulbig, MW, 2011) |
| "Male participants with and without type 1 diabetes were studied in the General Clinical Research Centre of the Albert Einstein College of Medicine." | 2.73 | Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes. ( Brownlee, M; Du, X; Edelstein, D, 2008) |
| "46 patients with type 1 diabetes and different forms of autonomic neuropathy, of mean age 38." | 2.71 | Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study). ( Dakovska, L; Koev, D; Tankova, T, 2004) |
| "Forty-nine patients (34 with Type 1 diabetes, 15 with Type 2 diabetes) had no antioxidant treatment and served as a control group." | 2.70 | Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study. ( Amiral, J; Borcea, V; Ehret, T; Gehrke, S; Henkels, M; Hofmann, M; Isermann, B; Morcos, M; Nawroth, PP; Schiekofer, S; Tritschler, H; Wahl, P; Ziegler, R, 2001) |
| "The objective of this study was to determine the impact of prolonged gastric emptying in patients with insulin dependent diabetes mellitus (IDDM) on the bioavailability of the R(+)- and S(-)-thioctic acid (TA) enantiomers." | 2.69 | Gastric emptying in patients with insulin dependent diabetes mellitus and bioavailability of thioctic acid-enantiomers. ( Gleiter, CH; Hermann, R; Niebch, G; Nowak, H; Ruus, P; Wildgrube, HJ, 1998) |
| "Diabetic polyneuropathy is a serious complication in patients with diabetes mellitus." | 2.69 | Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy. ( Amini, P; Frommeyer, R; Haak, E; Haak, T; Kusterer, K; Tritschler, HJ; Usadel, KH, 2000) |
| "Fulminant type 1 diabetes mellitus (FT1DM) has received clinical attention for its low incidence and poor prognosis." | 1.56 | Fulminant type 1 diabetes mellitus in pregnancy. ( Li, CY; Li, Y; Liu, YR; Mu, T; Wang, YJ; Yi, ZM; You, ZY; Zhang, YW; Zhao, CZ, 2020) |
| "Mitochondria play a role in type 1 diabetes (T1D) particularly in the treatment and prevention of disorder consequences." | 1.48 | Antibodies to post-translationally modified mitochondrial peptide PDC-E2(167-184) in type 1 diabetes. ( Crulli, M; Gallo, A; Lapolla, A; Nuti, F; Papini, AM; Peroni, E; Piarulli, F; Real-Fernandez, F; Rentier, C; Rossi, G; Rovero, P; Traldi, P, 2018) |
| " Dosage of the drug was 600 mg daily." | 1.39 | [Efficacy of thiolepta in diabetic polyneuropathy: results of the study ETIKA]. ( Fokina, AS; Golovacheva, VA; Kochetov, AG; Strokov, IA, 2013) |
| "In alloxan-treated mice (a model of type 1 diabetes), drugs were administered orally once daily for 6 days post-alloxan treatment." | 1.35 | Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment. ( Jiang, J; Larrick, JW; Wang, Y; Yu, P; Zeng, X; Zhang, Z, 2009) |
| "We included 43 patients with type 1 diabetes in this cross-sectional study." | 1.30 | Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes. ( Bierhaus, A; Hofmann, MA; Joswig, M; Kanitz, M; Klevesath, MS; Lee, V; Morcos, M; Nawroth, PP; Schiekofer, S; Tritschler, H; Wahl, P; Ziegler, R, 1998) |
| "Patients with diabetic nephropathy showed higher NF-kappaB binding activity in Electrophoretic Mobility Shift Assays and stronger immunohistological staining for activated NF-kappaBp65 than patients without renal complications." | 1.30 | Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB. ( Abdel Khalek, AK; Amiral, J; Bierhaus, A; Borcea, V; Henkels, M; Hofmann, MA; Isermann, B; Joswig, M; Kanitz, M; Morcos, M; Nawroth, PP; Ritz, E; Schiekofer, S; Treusch, A; Tritschler, H; Wahl, P; Weiss, T; Ziegler, R, 1999) |
| "As thioctic acid (TA) has favourable effects on glucose metabolism, the influence of this drug at two different doses (0." | 1.29 | The influence of thioctic acid on metabolism and function of the diabetic heart. ( Bretzel, RG; Federlin, K; Lehmann, E; Lehmann, U; Strödter, D; Tritschler, HJ, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (21.21) | 18.2507 |
| 2000's | 12 (36.36) | 29.6817 |
| 2010's | 11 (33.33) | 24.3611 |
| 2020's | 3 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, SH | 1 |
| Kuo, SL | 1 |
| Chen, SJ | 1 |
| Lin, JR | 1 |
| Chen, YW | 1 |
| Hong, ZJ | 1 |
| Sytwu, HK | 1 |
| Lin, GJ | 1 |
| Orellana-Donoso, M | 1 |
| López-Chaparro, M | 1 |
| Barahona-Vásquez, M | 1 |
| Santana-Machuca, A | 1 |
| Bruna-Mejias, A | 1 |
| Nova-Baeza, P | 1 |
| Valenzuela-Fuenzalida, JJ | 1 |
| Li, CY | 1 |
| Li, Y | 1 |
| You, ZY | 1 |
| Liu, YR | 1 |
| Wang, YJ | 1 |
| Mu, T | 1 |
| Zhao, CZ | 1 |
| Yi, ZM | 1 |
| Zhang, YW | 1 |
| Jurisic-Erzen, D | 1 |
| Starcevic-Klasan, G | 1 |
| Ivanac, D | 1 |
| Peharec, S | 1 |
| Girotto, D | 1 |
| Jerkovic, R | 1 |
| Nuti, F | 1 |
| Gallo, A | 1 |
| Real-Fernandez, F | 1 |
| Crulli, M | 1 |
| Rentier, C | 1 |
| Piarulli, F | 1 |
| Peroni, E | 1 |
| Rossi, G | 1 |
| Traldi, P | 1 |
| Rovero, P | 1 |
| Lapolla, A | 1 |
| Papini, AM | 1 |
| Strokov, IA | 2 |
| Fokina, AS | 1 |
| Golovacheva, VA | 1 |
| Kochetov, AG | 1 |
| Hegazy, SK | 1 |
| Tolba, OA | 1 |
| Mostafa, TM | 1 |
| Eid, MA | 1 |
| El-Afify, DR | 1 |
| Gębka, A | 1 |
| Serkies-Minuth, E | 1 |
| Raczyńska, D | 1 |
| Scaramuzza, A | 1 |
| Giani, E | 1 |
| Redaelli, F | 1 |
| Ungheri, S | 1 |
| Macedoni, M | 1 |
| Giudici, V | 1 |
| Bosetti, A | 1 |
| Ferrari, M | 1 |
| Zuccotti, GV | 1 |
| Verma, H | 1 |
| Garg, R | 1 |
| Zhang, S | 1 |
| Li, H | 1 |
| Zhang, L | 1 |
| Li, J | 1 |
| Wang, R | 1 |
| Wang, M | 1 |
| Du, X | 1 |
| Edelstein, D | 1 |
| Brownlee, M | 1 |
| Bureković, A | 1 |
| Terzić, M | 1 |
| Alajbegović, S | 1 |
| Vukojević, Z | 1 |
| Hadzić, N | 1 |
| Zhang, Z | 1 |
| Jiang, J | 1 |
| Yu, P | 1 |
| Zeng, X | 1 |
| Larrick, JW | 1 |
| Wang, Y | 1 |
| Navarese, EP | 2 |
| Mollo, R | 2 |
| Buffon, A | 1 |
| Haritoglou, C | 1 |
| Gerss, J | 1 |
| Hammes, HP | 1 |
| Kampik, A | 1 |
| Ulbig, MW | 1 |
| Zaccardi, F | 1 |
| Scalone, G | 1 |
| Scavone, G | 1 |
| Rizzo, P | 1 |
| Manto, A | 1 |
| Pitocco, D | 1 |
| Lanza, GA | 1 |
| Ghirlanda, G | 1 |
| Crea, F | 1 |
| Maritim, AC | 1 |
| Sanders, RA | 1 |
| Watkins, JB | 1 |
| Tankova, T | 1 |
| Koev, D | 1 |
| Dakovska, L | 1 |
| Song, KH | 1 |
| Lee, WJ | 1 |
| Koh, JM | 1 |
| Kim, HS | 1 |
| Youn, JY | 1 |
| Park, HS | 1 |
| Koh, EH | 1 |
| Kim, MS | 1 |
| Youn, JH | 1 |
| Lee, KU | 1 |
| Park, JY | 1 |
| Hermann, R | 1 |
| Wildgrube, HJ | 1 |
| Ruus, P | 1 |
| Niebch, G | 1 |
| Nowak, H | 1 |
| Gleiter, CH | 1 |
| Bregovskiĭ, VB | 1 |
| Posokhina, OV | 1 |
| Karpova, IA | 1 |
| Huang, EA | 1 |
| Gitelman, SE | 1 |
| Faust, A | 1 |
| Burkart, V | 1 |
| Ulrich, H | 1 |
| Weischer, CH | 1 |
| Kolb, H | 1 |
| Kähler, W | 1 |
| Kuklinski, B | 1 |
| Rühlmann, C | 1 |
| Plötz, C | 1 |
| Strödter, D | 1 |
| Lehmann, E | 1 |
| Lehmann, U | 1 |
| Tritschler, HJ | 3 |
| Bretzel, RG | 1 |
| Federlin, K | 1 |
| Hofmann, MA | 2 |
| Schiekofer, S | 3 |
| Kanitz, M | 2 |
| Klevesath, MS | 1 |
| Joswig, M | 2 |
| Lee, V | 1 |
| Morcos, M | 3 |
| Tritschler, H | 3 |
| Ziegler, R | 3 |
| Wahl, P | 3 |
| Bierhaus, A | 2 |
| Nawroth, PP | 3 |
| Isermann, B | 2 |
| Henkels, M | 2 |
| Treusch, A | 1 |
| Weiss, T | 1 |
| Borcea, V | 2 |
| Abdel Khalek, AK | 1 |
| Amiral, J | 2 |
| Ritz, E | 1 |
| Reljanovic, M | 1 |
| Reichel, G | 1 |
| Rett, K | 1 |
| Lobisch, M | 1 |
| Schuette, K | 1 |
| Möller, W | 1 |
| Mehnert, H | 1 |
| Tabatabaie, T | 1 |
| Graham, KL | 1 |
| Vasquez, AM | 1 |
| Floyd, RA | 1 |
| Kotake, Y | 1 |
| Haak, E | 1 |
| Usadel, KH | 1 |
| Kusterer, K | 1 |
| Amini, P | 1 |
| Frommeyer, R | 1 |
| Haak, T | 1 |
| Manukhina, EB | 1 |
| Bakhtina, LY | 1 |
| Malyshev, IY | 1 |
| Zoloev, GK | 1 |
| Kazikhanova, SI | 1 |
| Ametov, AS | 1 |
| Gehrke, S | 1 |
| Ehret, T | 1 |
| Hofmann, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of the Glucosamine Pathway and Reactive Oxygen Species in the Pathogenesis of Diabetic Complications[NCT00703989] | 21 participants (Actual) | Interventional | 2005-02-28 | Completed | |||
| Dose Finding and Tolerability Study of Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Peripheral Neuropathy[NCT01313117] | Phase 1/Phase 2 | 9 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients[NCT05023863] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601] | Phase 3 | 170 participants | Interventional | 2005-02-28 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 9 |
Based on acceptable adverse event (AE) profile and continual reassessment method dose escalation. (NCT01313117)
Timeframe: 4 months
| Intervention | mg (Number) |
|---|---|
| Alpha Lipoic Acid | 500 |
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 7 |
1 review available for thioctic acid and Autoimmune Diabetes
| Article | Year |
|---|---|
Effectiveness of alpha-lipoic acid in patients with neuropathic pain associated with type I and type II diabetes mellitus: A systematic review and meta-analysis.
Topics: Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Neuralgia; Thioctic Acid | 2023 |
15 trials available for thioctic acid and Autoimmune Diabetes
| Article | Year |
|---|---|
Alpha-lipoic acid improves subclinical left ventricular dysfunction in asymptomatic patients with type 1 diabetes.
Topics: Adolescent; Antioxidants; Child; Diabetes Mellitus, Type 1; Diabetic Cardiomyopathies; Female; Human | 2013 |
Effect of the administration of alpha-lipoic acid on contrast sensitivity in patients with type 1 and type 2 diabetes.
Topics: Adult; Aged; Antioxidants; Case-Control Studies; Contrast Sensitivity; Diabetes Mellitus, Type 1; Di | 2014 |
Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial.
Topics: Adolescent; Adolescent Nutritional Physiological Phenomena; Antioxidants; Cohort Studies; Combined M | 2015 |
Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Cytochrome P-450 Enzyme System; Diabe | 2008 |
Effect of alpha lipoic acid on cardiac autonomic dysfunction and platelet reactivity in type 1 diabetes: rationale and design of the AUTOnomic function and platelet REACTivity trial (AUTO-REACT protocol).
Topics: Antioxidants; Autonomic Nervous System; Blood Platelets; Diabetes Mellitus, Type 1; Humans; Thioctic | 2011 |
Alpha-lipoic acid for the prevention of diabetic macular edema.
Topics: Administration, Oral; Adult; Aged; Antioxidants; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes | 2011 |
Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients.
Topics: Adult; Antioxidants; Blood Platelets; C-Reactive Protein; Diabetes Mellitus, Type 1; Dinoprost; Fema | 2012 |
Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study).
Topics: Adult; Antioxidants; Autonomic Nervous System Diseases; Blood Pressure; Diabetes Mellitus, Type 1; D | 2004 |
Gastric emptying in patients with insulin dependent diabetes mellitus and bioavailability of thioctic acid-enantiomers.
Topics: Administration, Oral; Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Diabetes | 1998 |
The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus.
Topics: Administration, Oral; Adolescent; Age of Onset; Body Mass Index; Body Weight; Child; Delayed-Action | 2008 |
[Diabetes mellitus--a free radical-associated disease. Results of adjuvant antioxidant supplementation].
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropat | 1993 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Treatment of diabetic polyneuropathy with the antioxidant thioctic acid (alpha-lipoic acid): a two year multicenter randomized double-blind placebo-controlled trial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy.
Topics: Action Potentials; Adolescent; Adult; Aged; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellit | 1999 |
Effects of alpha-lipoic acid on microcirculation in patients with peripheral diabetic neuropathy.
Topics: Antioxidants; Blood Flow Velocity; Capillaries; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2 | 2000 |
The function of endogenous protective systems in patients with insulin-dependent diabetes mellitus and polyneuropathy: effect of antioxidant therapy.
Topics: Adolescent; Adult; Antioxidants; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Female; Heat-Shoc | 2000 |
Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study.
Topics: Albuminuria; Antioxidants; Biomarkers; Blood Pressure; Diabetes Mellitus, Type 1; Diabetes Mellitus, | 2001 |
17 other studies available for thioctic acid and Autoimmune Diabetes
| Article | Year |
|---|---|
Alpha-Lipoic Acid Inhibits Spontaneous Diabetes and Autoimmune Recurrence in Non-Obese Diabetic Mice by Enhancing Differentiation of Regulatory T Cells and Showed Potential for Use in Cell Therapies for the Treatment of Type 1 Diabetes.
Topics: Animals; Antioxidants; Autoimmunity; Cell Differentiation; Diabetes Mellitus, Experimental; Diabetes | 2022 |
Fulminant type 1 diabetes mellitus in pregnancy.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glycated Hemoglobin; Humans; Incidence; Inf | 2020 |
The effects of alpha-lipoic acid on diabetic myopathy.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Male; Muscle Fibe | 2018 |
Antibodies to post-translationally modified mitochondrial peptide PDC-E2(167-184) in type 1 diabetes.
Topics: Adult; Antibodies; Diabetes Mellitus, Type 1; Female; Glycosylation; Humans; Male; Mitochondrial Pro | 2018 |
[Efficacy of thiolepta in diabetic polyneuropathy: results of the study ETIKA].
Topics: Antioxidants; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropat | 2013 |
Comment on "Alpha-Lipoic Acid and Antioxidant Diet Help to Improve Endothelial Dysfunction in Adolescents with Type 1 Diabetes: A Pilot Trial".
Topics: Adolescent Nutritional Physiological Phenomena; Antioxidants; Diabetes Mellitus, Type 1; Diabetic An | 2015 |
Effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rats.
Topics: Animals; Cognition Disorders; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Evalu | 2017 |
The role of alpha-lipoic acid in diabetic polyneuropathy treatment.
Topics: Adult; Aged; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Hu | 2008 |
Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment.
Topics: Alloxan; Animals; Blood Glucose; Cytoprotection; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2009 |
Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Diabete | 2003 |
alpha-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Type 1; Disease Susceptibility; Male; Obesity | 2005 |
[Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs].
Topics: Adult; Antioxidants; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Electrophysiology; Female; Hu | 2005 |
Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice.
Topics: Animals; Antioxidants; Cyclophosphamide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 1994 |
The influence of thioctic acid on metabolism and function of the diabetic heart.
Topics: Adenosine Triphosphate; Animals; Cardiac Output; Cardiomyopathies; Diabetes Mellitus, Experimental; | 1995 |
Insufficient glycemic control increases nuclear factor-kappa B binding activity in peripheral blood mononuclear cells isolated from patients with type 1 diabetes.
Topics: Adult; Antioxidants; Biomarkers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 1; | 1998 |
Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.
Topics: Adult; Albuminuria; Antioxidants; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nep | 1999 |
Inhibition of the cytokine-mediated inducible nitric oxide synthase expression in rat insulinoma cells by phenyl N-tert-butylnitrone.
Topics: Acetylcysteine; Animals; Blotting, Northern; Cell Survival; Cyclic N-Oxides; Cytokines; Diabetes Mel | 2000 |