thioctic acid has been researched along with Apoplexy in 11 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Both α-lipoic acid and etanercept markedly reduced cerebral infarct, blood-brain barrier disruption, and neurological motor deficits with the former drug being more effective with the dosage used." | 1.43 | Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke. ( Chang, CP; Chio, CC; Huang, CC; Lin, MT; Lin, NK; Tsai, KJ; Wu, MH, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, C | 2 |
| Maharjan, S | 1 |
| Wang, Q | 2 |
| Sun, Y | 2 |
| Han, X | 2 |
| Wang, S | 2 |
| Mao, Z | 2 |
| Xin, Y | 2 |
| Zhang, B | 2 |
| Manolescu, BN | 1 |
| Berteanu, M | 1 |
| Cintezã, D | 1 |
| Connell, BJ | 4 |
| Saleh, MC | 4 |
| Kucukkaya, I | 2 |
| Abd-El-Aziz, AS | 2 |
| Khan, BV | 3 |
| Saleh, TM | 4 |
| Rajagopal, D | 3 |
| Choi, KH | 1 |
| Park, MS | 1 |
| Kim, HS | 2 |
| Kim, KT | 1 |
| Kim, JT | 1 |
| Kim, BC | 1 |
| Kim, MK | 1 |
| Park, JT | 1 |
| Cho, KH | 1 |
| Wu, MH | 1 |
| Huang, CC | 1 |
| Chio, CC | 1 |
| Tsai, KJ | 1 |
| Chang, CP | 1 |
| Lin, NK | 1 |
| Lin, MT | 1 |
| Kolesnichenko, LS | 1 |
| Kulinskiĭ, VI | 1 |
| Shprakh, VV | 1 |
| Bardymov, VV | 1 |
| Verlan, NV | 1 |
| Gubina, LP | 1 |
| Pensionerova, GA | 1 |
| Sergeeva, MP | 1 |
| Stanevich, LM | 1 |
| Filippova, GT | 1 |
| Fedin, AI | 1 |
| Kuznetsov, MR | 1 |
| Kholopova, EA | 1 |
| Dubrovin, EE | 1 |
| Ibragimov, TM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Lipoic Acid Use on Stroke Outcome After Reperfusion Therapy in Patients With Diabetes[NCT04041167] | Phase 3 | 120 participants (Anticipated) | Interventional | 2018-08-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for thioctic acid and Apoplexy
| Article | Year |
|---|---|
[Present-day possibilities of correcting impaired autoregulation of the cerebral circulation].
Topics: Antioxidants; Atherosclerosis; Cerebrovascular Circulation; Homeostasis; Humans; Lipid Peroxidation; | 2009 |
2 trials available for thioctic acid and Apoplexy
| Article | Year |
|---|---|
Effect of the nutritional supplement ALAnerv® on the serum PON1 activity in post-acute stroke patients.
Topics: Aged; Aryldialkylphosphatase; Dietary Supplements; Female; Humans; Male; Middle Aged; Oxidation-Redu | 2013 |
[The blood glutathione system in cerebral vascular diseases and its treatment with alpha-lipoic acid].
Topics: Aged; Female; Glutathione; Humans; Male; Middle Aged; Pilot Projects; Stroke; Thioctic Acid | 2008 |
8 other studies available for thioctic acid and Apoplexy
| Article | Year |
|---|---|
α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage.
Topics: Animals; Brain; Brain Edema; Cell Hypoxia; Cell Survival; Cells, Cultured; Disease Models, Animal; G | 2017 |
The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke.
Topics: Animals; Behavior, Animal; Brain Edema; Cell Line; Cyclooxygenase 2; Disease Models, Animal; Infarct | 2018 |
UPEI-300, a conjugate of lipoic acid and edaravone, mediates neuroprotection in ischemia/reperfusion.
Topics: Animals; Antipyrine; Brain Ischemia; Cell Hypoxia; Cells, Cultured; Drug Combinations; Male; Neocort | 2014 |
Co-administration of resveratrol and lipoic acid, or their synthetic combination, enhances neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Antioxidants; Brain Ischemia; Disease Models, Animal; Humans; Male; Rats; Rats, Sprague-Daw | 2014 |
Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats.
Topics: Animals; Biomarkers; Brain; Brain Infarction; Bromodeoxyuridine; Cell Proliferation; Doublecortin Pr | 2015 |
Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke.
Topics: Animals; Antioxidants; Brain; Brain Ischemia; Dose-Response Relationship, Drug; Down-Regulation; Dru | 2016 |
UPEI-400, a conjugate of lipoic acid and scopoletin, mediates neuroprotection in a rat model of ischemia/reperfusion.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Male; Neuroprotective Agents; Rats; Rats, Sprague-D | 2017 |
UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion.
Topics: Acetophenones; Animals; Biomarkers; Disease Models, Animal; Glutathione Disulfide; Infarction, Middl | 2012 |