thioctic acid has been researched along with Amyotrophic Lateral Sclerosis in 4 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the toxic effects of excess extracellular copper on motor neuronal cells expressing human mutant SOD1 (G93A), and evaluated the neuroprotective effects of energy metabolism intermediates or cofactors." | 1.33 | Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity. ( Kim, HJ; Kim, JM; Kim, M; Lee, KW; Park, JH; Sung, JJ, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, T | 1 |
| Cheng, J | 1 |
| Wang, S | 1 |
| Wang, X | 1 |
| Jiang, H | 1 |
| Yang, Y | 1 |
| Wang, Y | 1 |
| Zhang, C | 1 |
| Liang, W | 1 |
| Feng, H | 1 |
| Kim, HJ | 1 |
| Kim, JM | 1 |
| Park, JH | 1 |
| Sung, JJ | 1 |
| Kim, M | 1 |
| Lee, KW | 1 |
| Andreassen, OA | 1 |
| Dedeoglu, A | 1 |
| Friedlich, A | 1 |
| Ferrante, KL | 1 |
| Hughes, D | 1 |
| Szabo, C | 1 |
| Beal, MF | 1 |
| Currier, RD | 1 |
| Haerer, AF | 1 |
4 other studies available for thioctic acid and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
α-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Animals, Genetically Modified; Cell Line; Disease Models, An | 2018 |
Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity.
Topics: Amyotrophic Lateral Sclerosis; Cell Death; Cell Line, Tumor; Copper; Energy Metabolism; Free Radical | 2005 |
Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.
Topics: Amphetamines; Amyotrophic Lateral Sclerosis; Animals; Female; Male; Mice; Mice, Transgenic; Motor Sk | 2001 |
Amyotrophic lateral sclerosis and metallic toxins.
Topics: Adult; Aged; Agricultural Workers' Diseases; Amyotrophic Lateral Sclerosis; Arsenic; Chelating Agent | 1968 |