thioctic acid has been researched along with Alloxan Diabetes in 149 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Time-dependent effects of alpha-lipoic acid/nifedipine/glimepiride combination on diabetic neuropathies were investigated in rats." | 8.12 | Diurnal efficacy of alpha-lipoic acid/nifedipine/glimepiride combination mitigates diabetic neuropathies in rats. ( Anafi, SB; Bisalla, M; Olurishe, TO; Oraebosi, MI, 2022) |
| "Objective To observe the expression of Notch2, NLR family pyrin domain containing 3 (NLRP3) in the renal tissue of rats with diabetes mellitus (DM), and the effects of alpha-lipoamide (ALM) on the expression of Notch2, Toll-like receptor 4 (TLR4), NLRP3 and collagen, to explore the possible protective mechanism of ALM against diabetic renal inflammation and renal fibrosis." | 7.88 | [Alpha-lipoamide inhibits renal inflammation and collagen 4 production in diabetic rats and its mechanism]. ( Guo, B; Jiang, X; Mao, Y; Peng, C; Tang, L; Wang Wang, Y; Xiao, Y; Yuan, Z; Zhang, F; Zhang, Y, 2018) |
| "The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 7.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
| "The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied." | 7.81 | [Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes]. ( Faizullin, RM; Kalugina, AV; Miroshnichenko, IY; Pryakhina, KE; Rassokhina, LM; Volchegorskii, LA, 2015) |
| "The effects of original Russian preparations, derivatives of 3-hydroxypyridine and succinic acid (emoxipin, reamberin, mexidol), on the cellular composition of the cerebrocortical and diencephalic structures were studied and correlations of shifts in the cellular composition with changes in the severity of hyperglycemia in rats with alloxan diabetes were analyzed." | 7.79 | Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes. ( Miroshnichenko, IY; Rassokhina, LM; Volchegorskii, IA, 2013) |
| "Time-dependent effects of alpha-lipoic acid/nifedipine/glimepiride combination on diabetic neuropathies were investigated in rats." | 4.12 | Diurnal efficacy of alpha-lipoic acid/nifedipine/glimepiride combination mitigates diabetic neuropathies in rats. ( Anafi, SB; Bisalla, M; Olurishe, TO; Oraebosi, MI, 2022) |
| " The aim of this study was to evaluate the interaction of pregabalin + thioctic acid or pregabalin + α-tocopherol on allodynia and motor performance in neonatal streptozotocin-induced diabetic rats." | 3.88 | Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α-tocopherol combinations in neonatal streptozotocin-induced diabetic rats. ( Araiza-Saldaña, CI; Cruz-Álvarez, LE; Flores-Murrieta, FJ; Huerta-Cruz, JC; Reyes-García, JG; Rocha-González, HI; Zúñiga-Romero, Á, 2018) |
| "Objective To observe the expression of Notch2, NLR family pyrin domain containing 3 (NLRP3) in the renal tissue of rats with diabetes mellitus (DM), and the effects of alpha-lipoamide (ALM) on the expression of Notch2, Toll-like receptor 4 (TLR4), NLRP3 and collagen, to explore the possible protective mechanism of ALM against diabetic renal inflammation and renal fibrosis." | 3.88 | [Alpha-lipoamide inhibits renal inflammation and collagen 4 production in diabetic rats and its mechanism]. ( Guo, B; Jiang, X; Mao, Y; Peng, C; Tang, L; Wang Wang, Y; Xiao, Y; Yuan, Z; Zhang, F; Zhang, Y, 2018) |
| "The purpose of this study was to determine whether α-lipoic acid and fisetin have protective effects against cataract in a streptozotocin-induced experimental cataract model." | 3.81 | Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice. ( Ayar, A; Çolak, R; Kan, E; Kiliçkan, E, 2015) |
| "The effects of 3-oxypyridine and succinic acid derivatives (emoxipine, reamberin and mexidol) on affective disorders in rats with alloxan diabetes were studied." | 3.81 | [Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes]. ( Faizullin, RM; Kalugina, AV; Miroshnichenko, IY; Pryakhina, KE; Rassokhina, LM; Volchegorskii, LA, 2015) |
| "The effects of original Russian preparations, derivatives of 3-hydroxypyridine and succinic acid (emoxipin, reamberin, mexidol), on the cellular composition of the cerebrocortical and diencephalic structures were studied and correlations of shifts in the cellular composition with changes in the severity of hyperglycemia in rats with alloxan diabetes were analyzed." | 3.79 | Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes. ( Miroshnichenko, IY; Rassokhina, LM; Volchegorskii, IA, 2013) |
| " Compared with control rats, D developed increased urinary excretion of albumin and transforming growth factor beta, renal insufficiency, glomerular mesangial matrix expansion, and glomerulosclerosis in association with depletion of glutathione and accumulation of malondialdehyde in renal cortex." | 3.71 | Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes. ( Craven, PA; DeRubertis, FR; Liachenko, J; Melhem, MF, 2002) |
| "This study investigated the effects of trelagliptin and remogliflozin, alone and in combination with alpha lipoic acid (ALA), on cardiac biomarkers in diabetic cardiomyopathy (DCM)." | 1.91 | Impacts of trelagliptin and remogliflozin alone and in combination with Alpha Lipoic Acid on cardiac function in streptozotocin-induced diabetes mellitus in rats. ( Abdullah Ali, M; Kareem Hamad, B; Naji Alhassani, A, 2023) |
| "Metformin has beneficial pharmacological effects on the preservation of peripheral nerves in diabetic rats and its effects are comparable to those of ALA." | 1.56 | Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats. ( Jin, HY; Kim, SH; Park, TS, 2020) |
| "Diabetic neuropathies are a family of nerve disorders caused by diabetes." | 1.35 | Coenzyme Q(10) and alpha-lipoic acid supplementation in diabetic rats: conduction velocity distributions. ( Ayaz, M; Gokbel, H; Okudan, N; Tuncer, S, 2008) |
| "In alloxan-treated mice (a model of type 1 diabetes), drugs were administered orally once daily for 6 days post-alloxan treatment." | 1.35 | Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment. ( Jiang, J; Larrick, JW; Wang, Y; Yu, P; Zeng, X; Zhang, Z, 2009) |
| " Improved endothelial function due to alpha-LA was at least partially attributed to recoupling of eNOS and increased NO bioavailability and represents a pharmacological approach to prevent major complications associated with type 2 diabetes." | 1.35 | Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats. ( Boarder, MR; Fernandes, R; Louro, T; Nunes, E; Proença, T; Seiça, RM; Sena, CM, 2008) |
| "ALA plays an important role in treatment of erectile dysfunction by decreasing iNOS and increasing other isoforms of NOS." | 1.33 | The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats. ( Citci, S; Demirci, C; Hurdag, C; Ozkara, H; Uyaner, I, 2005) |
| "We hypothesized that streptozotocin diabetes in rats and mice would result in an early reduction in podocyte density and that this reduction would be prevented by antioxidants." | 1.33 | Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: prevention by lipoic acid treatment. ( Brosius, FC; Saha, J; Siu, B; Smoyer, WE; Sullivan, KA, 2006) |
| " Our results demonstrate that the long-term administration of alpha-lipoic acid has beneficial effects on the development of diabetic retinopathy via inhibition of accumulation of oxidatively modified DNA and nitrotyrosine in the retina." | 1.32 | Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. ( Kowluru, RA; Odenbach, S, 2004) |
| "Substance P was depleted to 51% in the control rats (p < 0." | 1.31 | Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy. ( Corder, R; Hounsom, L; Patel, J; Tomlinson, DR, 2001) |
| "In rats treated only during pregnancy days 1 to 5 (before diabetes induction), lipoic acid failed to exert its protective effects against neural tube defects, which emphasizes the importance of the presence of lipoic acid during the organogenesis period." | 1.30 | Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes. ( Ayalon, N; Bashan, N; Hershkovitz, R; Khamaisi, M; Reece, EA; Trischler, H; Wiznitzer, A, 1999) |
| " In conclusion, this study suggests that short-term administration of LA at high dosage to normal and diabetic rats causes an inhibition of gluconeogenesis secondary to an interference with hepatic fatty acid oxidation." | 1.30 | Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats. ( Bashan, N; Gutman, A; Khamaisi, M; Potashnik, R; Rudich, A; Tritschler, HJ, 1999) |
| "As thioctic acid (TA) has favourable effects on glucose metabolism, the influence of this drug at two different doses (0." | 1.29 | The influence of thioctic acid on metabolism and function of the diabetic heart. ( Bretzel, RG; Federlin, K; Lehmann, E; Lehmann, U; Strödter, D; Tritschler, HJ, 1995) |
| "Formation of lens opacities in vitro was correlated with lactate dehydrogenase (LDH) leakage into the incubation medium." | 1.29 | Modelling cortical cataractogenesis 17: in vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis. ( Handelman, GJ; Kilic, F; Packer, L; Serbinova, E; Trevithick, JR, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (1.34) | 18.7374 |
| 1990's | 17 (11.41) | 18.2507 |
| 2000's | 57 (38.26) | 29.6817 |
| 2010's | 53 (35.57) | 24.3611 |
| 2020's | 20 (13.42) | 2.80 |
| Authors | Studies |
|---|---|
| Sajadimajd, S | 1 |
| Khosravifar, M | 1 |
| Bahrami, G | 1 |
| Oraebosi, MI | 2 |
| Olurishe, TO | 2 |
| Anafi, SB | 2 |
| Bisalla, M | 2 |
| Ramos, CSCB | 1 |
| Silva, VAPD | 1 |
| Corrêa, LBNS | 1 |
| Abboud, RS | 1 |
| Boaventura, GT | 1 |
| Chagas, MA | 1 |
| Mokhtari, B | 1 |
| Abdoli-Shadbad, M | 1 |
| Alihemmati, A | 2 |
| Javadi, A | 1 |
| Badalzadeh, R | 2 |
| Tanbek, K | 1 |
| Ozerol, E | 1 |
| Yilmaz, U | 1 |
| Yilmaz, N | 1 |
| Gul, M | 2 |
| Colak, C | 1 |
| Huang, SH | 1 |
| Kuo, SL | 1 |
| Chen, SJ | 1 |
| Lin, JR | 1 |
| Chen, YW | 1 |
| Hong, ZJ | 1 |
| Sytwu, HK | 1 |
| Lin, GJ | 1 |
| Dugbartey, GJ | 2 |
| Alornyo, KK | 2 |
| N'guessan, BB | 1 |
| Atule, S | 1 |
| Mensah, SD | 1 |
| Adjei, S | 1 |
| Alhakamy, NA | 1 |
| Mohamed, GA | 1 |
| Fahmy, UA | 1 |
| Eid, BG | 1 |
| Al-Rabia, MW | 1 |
| Khedr, AIM | 1 |
| Nasrullah, MZ | 1 |
| Ibrahim, SRM | 1 |
| Abdel-Naim, AB | 1 |
| Ahmed, OAA | 1 |
| Md, S | 1 |
| Wonje, QL | 1 |
| Adams, I | 1 |
| Diaba, DE | 1 |
| Gholami, S | 1 |
| Abdullah Ali, M | 1 |
| Naji Alhassani, A | 1 |
| Kareem Hamad, B | 1 |
| Kayhan Kuştepe, E | 1 |
| Bahar, L | 2 |
| Zayman, E | 1 |
| Sucu, N | 2 |
| Gül, S | 1 |
| Eras, N | 1 |
| Bagdatoglu, OT | 1 |
| Yildirim, M | 2 |
| Zhang, BY | 1 |
| Zhang, YL | 1 |
| Sun, Q | 2 |
| Zhang, PA | 1 |
| Wang, XX | 1 |
| Xu, GY | 2 |
| Hu, J | 2 |
| Zhang, HH | 2 |
| Kim, SH | 3 |
| Park, TS | 4 |
| Jin, HY | 4 |
| Won, JC | 1 |
| Koo, BK | 1 |
| Dong, J | 1 |
| Wang, Y | 5 |
| Yi, S | 1 |
| Zhao, T | 1 |
| Xu, Y | 1 |
| Davidson, EP | 4 |
| Coppey, LJ | 5 |
| Shevalye, H | 2 |
| Obrosov, A | 2 |
| Kardon, RH | 2 |
| Yorek, MA | 6 |
| Qin, X | 1 |
| Song, ZY | 1 |
| Yang, PP | 1 |
| Feng, Y | 2 |
| Jurisic-Erzen, D | 1 |
| Starcevic-Klasan, G | 1 |
| Ivanac, D | 1 |
| Peharec, S | 1 |
| Girotto, D | 1 |
| Jerkovic, R | 1 |
| Dworacka, M | 1 |
| Chukanova, G | 1 |
| Iskakova, S | 1 |
| Kurmambayev, Y | 1 |
| Wesołowska, A | 1 |
| Frycz, BA | 1 |
| Jagodziński, PP | 1 |
| Dworacki, G | 1 |
| Lee, KA | 2 |
| Lee, NY | 1 |
| Kim, YS | 1 |
| Kim, M | 1 |
| Choi, MY | 1 |
| Lee, DH | 1 |
| Roh, GS | 1 |
| Kim, HJ | 1 |
| Kang, SS | 1 |
| Cho, GJ | 1 |
| Hong, EK | 1 |
| Choi, WS | 1 |
| Tasci, I | 1 |
| Demir, CF | 1 |
| Kuloglu, T | 1 |
| Cruz-Álvarez, LE | 1 |
| Zúñiga-Romero, Á | 1 |
| Huerta-Cruz, JC | 1 |
| Flores-Murrieta, FJ | 1 |
| Reyes-García, JG | 1 |
| Araiza-Saldaña, CI | 1 |
| Rocha-González, HI | 1 |
| Peng, C | 1 |
| Jiang, X | 1 |
| Xiao, Y | 1 |
| Yuan, Z | 1 |
| Mao, Y | 1 |
| Wang Wang, Y | 1 |
| Zhang, Y | 1 |
| Zhang, F | 1 |
| Tang, L | 1 |
| Guo, B | 1 |
| Sadeghiyan Galeshkalami, N | 1 |
| Abdollahi, M | 1 |
| Najafi, R | 1 |
| Baeeri, M | 1 |
| Jamshidzade, A | 1 |
| Falak, R | 1 |
| Davoodzadeh Gholami, M | 1 |
| Hassanzadeh, G | 1 |
| Mokhtari, T | 1 |
| Hassani, S | 1 |
| Rahimifard, M | 1 |
| Hosseini, A | 1 |
| Gao, T | 1 |
| Qian, S | 1 |
| Shen, S | 1 |
| Zhang, X | 1 |
| Liu, J | 1 |
| Jia, W | 1 |
| Chen, Z | 1 |
| Ye, J | 1 |
| Feng, B | 1 |
| Yan, XF | 1 |
| Xue, JL | 1 |
| Xu, L | 2 |
| Wang, H | 1 |
| Al-Rasheed, NM | 2 |
| Attia, HA | 1 |
| Hasan, IH | 1 |
| Al-Amin, M | 1 |
| Al-Ajmi, H | 1 |
| Mohamad, RA | 1 |
| Volchegorskii, IA | 3 |
| Rassokhina, LM | 4 |
| Miroshnichenko, IY | 2 |
| Nebbioso, M | 1 |
| Pranno, F | 1 |
| Pescosolido, N | 1 |
| Chen, CL | 1 |
| Cheng, WS | 1 |
| Chen, JL | 1 |
| Chiang, CH | 1 |
| Zhao, L | 1 |
| Ma, X | 1 |
| Deng, X | 1 |
| Wu, JZ | 1 |
| Baek, HS | 1 |
| Dominguez, JM | 1 |
| Grant, MB | 1 |
| Kan, E | 2 |
| Kiliçkan, E | 1 |
| Ayar, A | 2 |
| Çolak, R | 1 |
| Berkowitz, BA | 3 |
| Grady, EM | 1 |
| Khetarpal, N | 1 |
| Patel, A | 1 |
| Roberts, R | 3 |
| Li, Y | 1 |
| Yan, H | 1 |
| Zhang, Z | 2 |
| Zhang, G | 1 |
| Sun, Y | 1 |
| Yu, P | 2 |
| Volchegorskii, LA | 1 |
| Faizullin, RM | 1 |
| Pryakhina, KE | 1 |
| Kalugina, AV | 1 |
| Mao, ZM | 1 |
| Shen, SM | 1 |
| Wan, YG | 1 |
| Sun, W | 1 |
| Chen, HL | 1 |
| Huang, MM | 1 |
| Yang, JJ | 1 |
| Wu, W | 1 |
| Tang, HT | 1 |
| Tang, RM | 1 |
| Holmes, A | 1 |
| Ozgun, E | 1 |
| Ozgun, GS | 1 |
| Gokmen, SS | 1 |
| Eskıocak, S | 1 |
| Sut, N | 1 |
| Akıncı, M | 1 |
| Goncu, E | 1 |
| Cakır, E | 1 |
| Alici, Ö | 1 |
| Kan, EK | 1 |
| Zhang, S | 1 |
| Li, H | 2 |
| Zhang, L | 1 |
| Li, J | 1 |
| Wang, R | 1 |
| Wang, M | 1 |
| Yorek, MS | 1 |
| Al-Matubsi, HY | 1 |
| Oriquat, GA | 1 |
| Abu-Samak, M | 1 |
| Al Hanbali, OA | 1 |
| Salim, MD | 1 |
| Zhang, T | 1 |
| Gao, Y | 1 |
| Gong, Y | 1 |
| Zhou, H | 1 |
| Xie, P | 1 |
| Guan, S | 1 |
| Yi, W | 1 |
| Johnsen-Soriano, S | 1 |
| Garcia-Pous, M | 1 |
| Arnal, E | 1 |
| Sancho-Tello, M | 1 |
| Garcia-Delpech, S | 1 |
| Miranda, M | 1 |
| Bosch-Morell, F | 1 |
| Diaz-Llopis, M | 1 |
| Navea, A | 1 |
| Romero, FJ | 1 |
| Ayaz, M | 1 |
| Tuncer, S | 1 |
| Okudan, N | 2 |
| Gokbel, H | 2 |
| Luz, J | 1 |
| Zemdegs, JC | 1 |
| Amaral, LS | 1 |
| Balkis Budin, S | 1 |
| Othman, F | 1 |
| Louis, SR | 1 |
| Abu Bakar, M | 1 |
| Radzi, M | 1 |
| Osman, K | 1 |
| Das, S | 1 |
| Mohamed, J | 1 |
| Sugimura, Y | 1 |
| Murase, T | 1 |
| Kobayashi, K | 1 |
| Oyama, K | 1 |
| Hayasaka, S | 1 |
| Kanou, Y | 1 |
| Oiso, Y | 1 |
| Murata, Y | 1 |
| Jiang, J | 1 |
| Zeng, X | 1 |
| Larrick, JW | 1 |
| Yao, LS | 1 |
| Wang, YT | 1 |
| Chen, Y | 1 |
| Dai, YT | 1 |
| Bu, L | 1 |
| Liu, ZM | 1 |
| Kanter, M | 1 |
| Sen, S | 1 |
| Donmez, S | 1 |
| Aktas, C | 1 |
| Ustundag, S | 1 |
| Erboga, M | 1 |
| Lappalainen, Z | 2 |
| Lappalainen, J | 3 |
| Laaksonen, DE | 3 |
| Oksala, KJ | 1 |
| Khanna, S | 3 |
| Sen, CK | 3 |
| Atalay, M | 3 |
| Oksala, NK | 2 |
| Mohasseb, M | 1 |
| Ebied, S | 1 |
| Yehia, MA | 1 |
| Hussein, N | 1 |
| Morgado, C | 1 |
| Pereira-Terra, P | 1 |
| Tavares, I | 1 |
| Nurullahoğlu Atalik, KE | 1 |
| Canbilen, A | 1 |
| Kara, I | 1 |
| Li, XZ | 1 |
| Yan, HD | 1 |
| Wang, J | 1 |
| Sudheesh, NP | 1 |
| Ajith, TA | 1 |
| Janardhanan, KK | 1 |
| Krishnan, CV | 1 |
| Miroshnichenko, IIu | 2 |
| Karatug, A | 1 |
| Bolkent, S | 1 |
| Santos, JM | 1 |
| Kowluru, RA | 2 |
| Sadi, G | 2 |
| Eryilmaz, N | 1 |
| Tütüncüoğlu, E | 1 |
| Cingir, Ş | 1 |
| Güray, T | 2 |
| Gao, S | 1 |
| Yuan, K | 1 |
| Shah, A | 1 |
| Kim, JS | 1 |
| Park, WH | 1 |
| Mirjana, M | 1 |
| Jelena, A | 1 |
| Aleksandra, U | 1 |
| Svetlana, D | 1 |
| Nevena, G | 1 |
| Jelena, M | 1 |
| Goran, P | 1 |
| Melita, V | 1 |
| Chen, WL | 1 |
| Kang, CH | 1 |
| Wang, SG | 1 |
| Lee, HM | 1 |
| Li, CJ | 1 |
| Lv, L | 1 |
| Yu, DM | 1 |
| Chen, SA | 1 |
| Chen, HM | 1 |
| Yao, YD | 1 |
| Hung, CF | 1 |
| Tu, CS | 1 |
| Liang, YJ | 1 |
| Arambašić, J | 2 |
| Mihailović, M | 2 |
| Uskoković, A | 2 |
| Dinić, S | 2 |
| Grdović, N | 2 |
| Marković, J | 2 |
| Poznanović, G | 2 |
| Bajec, D | 1 |
| Vidaković, M | 2 |
| Mıcılı, SC | 1 |
| Ergur, BU | 1 |
| Ozoğul, C | 2 |
| Sarıoğlu, S | 1 |
| Bağrıyanık, HA | 1 |
| Tuğyan, K | 1 |
| Pekcetin, C | 1 |
| Sonmez, U | 1 |
| Tekmen, I | 1 |
| Erbil, G | 1 |
| Akdoğan, GG | 1 |
| Ozyurt, D | 1 |
| Buldan, Z | 1 |
| Karadžić, B | 1 |
| Yilmaz, O | 3 |
| Ozkan, Y | 2 |
| Oztürk, AI | 2 |
| Erşan, Y | 2 |
| Abiko, T | 1 |
| Abiko, A | 1 |
| Clermont, AC | 1 |
| Shoelson, B | 1 |
| Horio, N | 1 |
| Takahashi, J | 1 |
| Adamis, AP | 1 |
| King, GL | 1 |
| Bursell, SE | 1 |
| Midaoui, AE | 1 |
| Elimadi, A | 1 |
| Wu, L | 1 |
| Haddad, PS | 1 |
| de Champlain, J | 1 |
| Gellett, JS | 2 |
| Maritim, AC | 3 |
| Sanders, RA | 3 |
| Watkins, JB | 3 |
| Gibson, TM | 1 |
| Cotter, MA | 5 |
| Cameron, NE | 5 |
| BUTTURINI, U | 1 |
| Gouty, S | 1 |
| Regalia, J | 1 |
| Cai, F | 1 |
| Helke, CJ | 1 |
| Bojunga, J | 1 |
| Dresar-Mayert, B | 1 |
| Usadel, KH | 1 |
| Kusterer, K | 1 |
| Zeuzem, S | 1 |
| Shotton, HR | 1 |
| Broadbent, S | 1 |
| Lincoln, J | 1 |
| Kumar, MS | 1 |
| Prashanth, KV | 1 |
| Sun, L | 1 |
| Zhang, JS | 1 |
| Alderson, NL | 1 |
| Chachich, ME | 1 |
| Frizzell, N | 1 |
| Canning, P | 1 |
| Metz, TO | 1 |
| Januszewski, AS | 1 |
| Youssef, NN | 1 |
| Stitt, AW | 1 |
| Baynes, JW | 1 |
| Thorpe, SR | 1 |
| Al Ghafli, MH | 1 |
| Padmanabhan, R | 1 |
| Kataya, HH | 1 |
| Berg, B | 1 |
| Baydas, G | 1 |
| Donder, E | 1 |
| Kiliboz, M | 1 |
| Sonkaya, E | 1 |
| Tuzcu, M | 1 |
| Yasar, A | 1 |
| Nedzvetskii, VS | 1 |
| Odenbach, S | 1 |
| Berryman, AM | 1 |
| Dene, BA | 1 |
| Bhatti, F | 1 |
| Mankhey, RW | 1 |
| Asico, L | 1 |
| Quinn, MT | 1 |
| Welch, WJ | 1 |
| Maric, C | 1 |
| Lateef, H | 1 |
| Aslam, MN | 1 |
| Stevens, MJ | 5 |
| Varani, J | 1 |
| Hurdag, C | 1 |
| Ozkara, H | 1 |
| Citci, S | 1 |
| Uyaner, I | 1 |
| Demirci, C | 1 |
| Lin, J | 1 |
| Bierhaus, A | 1 |
| Bugert, P | 1 |
| Dietrich, N | 1 |
| Vom Hagen, F | 1 |
| Nawroth, P | 1 |
| Brownlee, M | 1 |
| Hammes, HP | 1 |
| Siu, B | 1 |
| Saha, J | 1 |
| Smoyer, WE | 1 |
| Sullivan, KA | 1 |
| Brosius, FC | 1 |
| Yi, X | 1 |
| Maeda, N | 1 |
| Luan, H | 2 |
| Price, SA | 1 |
| Gardiner, NJ | 1 |
| Duran-Jimenez, B | 1 |
| Zeef, LA | 1 |
| Obrosova, IG | 4 |
| Tomlinson, DR | 5 |
| Pitel, S | 1 |
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| Nickander, KK | 2 |
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| Low, PA | 2 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2) Randomised, Double-blind,Placebo-controlled Multicentre Trial With 4 Parallel Groups[NCT00328601] | Phase 3 | 170 participants | Interventional | 2005-02-28 | Completed | ||
| Phase 1 Study To Determine the Effects of Short Term Near-infrared Light (NIR) Therapy on Anatomic and Functional Abnormalities of Diabetic Macular Edema, and Assess Safety of Short Term Near-infrared Light Therapy in Eyes With Diabetic Macular Edema.[NCT00846092] | Phase 1 | 4 participants (Actual) | Interventional | 2007-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thioctic acid and Alloxan Diabetes
| Article | Year |
|---|---|
Lipoic acid in animal models and clinical use in diabetic retinopathy.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Humans; Thioctic Acid | 2013 |
Antioxidant properties of lipoic acid and its therapeutic effects in prevention of diabetes complications and cataracts.
Topics: Animals; Antimetabolites; Antioxidants; Buthionine Sulfoximine; Cataract; Diabetes Mellitus, Experim | 1994 |
147 other studies available for thioctic acid and Alloxan Diabetes
| Article | Year |
|---|---|
Anti-Diabetic Effects of Isolated Lipids from Natural Sources through Modulation of Angiogenesis.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Fatty Acids, Omega-3; Humans; Linsee | 2022 |
Diurnal efficacy of alpha-lipoic acid/nifedipine/glimepiride combination mitigates diabetic neuropathies in rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Nifedipine; Rats; Sul | 2022 |
Long-Term Alpha-Lipoic Acid (ALA) Antioxidant Therapy Reduces Damage in the Cardiovascular System of Streptozotocin-Induced Diabetic Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Aorta; Diabetes Mellitus, Experimental; Male; Rats; | 2023 |
Alpha-lipoic acid preconditioning plus ischemic postconditioning provides additional protection against myocardial reperfusion injury of diabetic rats: modulation of autophagy and mitochondrial function.
Topics: Animals; Autophagy; Diabetes Mellitus, Experimental; Ischemic Postconditioning; Ischemic Preconditio | 2022 |
Alpha lipoic acid decreases neuronal damage on brain tissue of STZ-induced diabetic rats.
Topics: Animals; Antioxidants; Brain; Diabetes Mellitus, Experimental; Male; Oxidative Stress; Rats; Rats, W | 2022 |
Alpha-Lipoic Acid Inhibits Spontaneous Diabetes and Autoimmune Recurrence in Non-Obese Diabetic Mice by Enhancing Differentiation of Regulatory T Cells and Showed Potential for Use in Cell Therapies for the Treatment of Type 1 Diabetes.
Topics: Animals; Antioxidants; Autoimmunity; Cell Differentiation; Diabetes Mellitus, Experimental; Diabetes | 2022 |
Supplementation of conventional anti-diabetic therapy with alpha-lipoic acid prevents early development and progression of diabetic nephropathy.
Topics: Animals; Antioxidants; Creatinine; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabe | 2022 |
Thioctamer: a novel thioctic acid-glatiramer acetate nanoconjugate expedites wound healing in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glatiramer Acetate; Hydrogels; Interleukin-6; Nanoconjugat | 2022 |
Alpha-lipoic acid treatment improves adverse cardiac remodelling in the diabetic heart - The role of cardiac hydrogen sulfide-synthesizing enzymes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Hydr | 2022 |
Alpha-lipoic acid enhances ischemic postconditioning-mediated improvement of myocardial infarction and apoptosis in diabetic rats with ischemia/reperfusion injury.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Diabetes Mellitus, Experimental; Ischemic Postcondit | 2023 |
Impacts of trelagliptin and remogliflozin alone and in combination with Alpha Lipoic Acid on cardiac function in streptozotocin-induced diabetes mellitus in rats.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Diabetic Cardiomyopathies; Inflammation; Male; | 2023 |
A light microscopic investigation of the renoprotective effects of α-lipoic acid and α-tocopherol in an experimental diabetic rat model.
Topics: alpha-Tocopherol; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Ma | 2020 |
Adrenomedullin expression in aortic artery wall of diabetic rats given alpha lipoic acid.
Topics: Adrenomedullin; Animals; Antioxidants; Aorta; Diabetes Mellitus, Experimental; Endothelium, Vascular | 2020 |
Alpha-lipoic acid downregulates TRPV1 receptor via NF-κB and attenuates neuropathic pain in rats with diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Female; Ganglia, Spinal; Neuralgia; NF-kappa | 2020 |
Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet, High-Fat; Male; Metformin; Ra | 2020 |
Chronopharmacology of the alpha-lipoic acid/nifedipine/glimepiride combination in the amelioration of retinopathy in rats.
Topics: Animals; Antioxidants; Circadian Rhythm; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Nife | 2021 |
The Anti-Diabetic Drug Metformin from the Neuropathy Perspective.
Topics: Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Metformin; Peripheral Nerves; Pharmaceutic | 2020 |
Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats (Diabetes Metab J 2020;44:842-53).
Topics: Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Metformin; Peripheral Nerves; Rats; Strept | 2021 |
Metformin Preserves Peripheral Nerve Damage with Comparable Effects to Alpha Lipoic Acid in Streptozotocin/High-Fat Diet Induced Diabetic Rats (Diabetes Metab J 2020;44:842-53).
Topics: Animals; Diabetes Mellitus, Experimental; Diet, High-Fat; Metformin; Peripheral Nerves; Rats; Strept | 2021 |
α-Lipoic acid ameliorates renal fibrosis in diabetic rats through TGF-β1/Smads signaling pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Fibrosis; Humans; Kidney Diseases; Rats; Signal Transducti | 2022 |
Impaired Corneal Sensation and Nerve Loss in a Type 2 Rat Model of Chronic Diabetes Is Reversible With Combination Therapy of Menhaden Oil, α-Lipoic Acid, and Enalapril.
Topics: Adiponectin; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Cornea; Diabetes Mell | 2017 |
Alpha-lipoic Acid suppresses P2X receptor activities and visceral hypersensitivity to colorectal distention in diabetic rats.
Topics: Animals; Colon; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Models, Animal; Fem | 2017 |
The effects of alpha-lipoic acid on diabetic myopathy.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Male; Muscle Fibe | 2018 |
New arguments for beneficial effects of alpha-lipoic acid on the cardiovascular system in the course of type 2 diabetes.
Topics: Animals; Antioxidants; Aorta; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2018 |
Comparison of peripheral nerve protection between insulin-based glucose control and alpha lipoic acid (ALA) in the streptozotocin (STZ)-induced diabetic rat.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hypoglycemic Agents; | 2018 |
Alpha-lipoic acid reduces retinal cell death in diabetic mice.
Topics: Administration, Oral; AMP-Activated Protein Kinases; Animals; Cell Death; Cells, Cultured; Diabetes | 2018 |
Effects of Alpha Lipoic Acid on Loss of Myelin Sheath of Sciatic Nerve in Experimentally Induced Diabetic Rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Anima | 2018 |
Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α-tocopherol combinations in neonatal streptozotocin-induced diabetic rats.
Topics: alpha-Tocopherol; Analgesics; Animals; Animals, Newborn; Antioxidants; Diabetes Mellitus, Experiment | 2018 |
[Alpha-lipoamide inhibits renal inflammation and collagen 4 production in diabetic rats and its mechanism].
Topics: Animals; Collagen Type IV; Diabetes Mellitus, Experimental; Inflammation; Interleukin-6; Kidney; NLR | 2018 |
Alpha-lipoic acid and coenzyme Q10 combination ameliorates experimental diabetic neuropathy by modulating oxidative stress and apoptosis.
Topics: Administration, Oral; Animals; Apoptosis; Biomarkers; Blotting, Western; Caspase 3; Diabetes Mellitu | 2019 |
Reduction of mitochondrial 3-oxoacyl-ACP synthase (OXSM) by hyperglycemia is associated with deficiency of α-lipoic acid synthetic pathway in kidney of diabetic mice.
Topics: 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; 3T3-L1 Cells; Animals; Biosynthetic Pathways; Diabetes Me | 2019 |
The protective effects of α-lipoic acid on kidneys in type 2 diabetic Goto-Kakisaki rats via reducing oxidative stress.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glu | 2013 |
Adverse cardiac responses to alpha-lipoic acid in a rat-diabetic model: possible mechanisms?
Topics: Animals; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Experimental; Glycation End Products | 2013 |
Cerebroprotective effects of emoxipin, reamberin, and mexidol in alloxan diabetes.
Topics: Alloxan; Animals; Astrocytes; Cerebral Cortex; Diabetes Mellitus, Experimental; Diencephalon; Female | 2013 |
Potential of nonoral α-lipoic acid aqueous formulations to reduce ocular microvascular complications in a streptozotocin-induced diabetic rat model.
Topics: Administration, Ophthalmic; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinop | 2013 |
Oxidative stress impairs IKCa- and SKCa-mediated vasodilatation in mesenteric arteries from diabetic rats.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Human Umbilical Vein Endothelial Cells; H | 2013 |
The neuroprotective benefit from pioglitazone (PIO) addition on the alpha lipoic acid (ALA)-based treatment in experimental diabetic rats.
Topics: Animals; Axons; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Therapy, | 2014 |
Combination therapies prevent the neuropathic, proinflammatory characteristics of bone marrow in streptozotocin-induced diabetic rats.
Topics: Adipose Tissue; Animals; Bone Marrow; Cytokines; Diabetes Mellitus, Experimental; Diabetic Neuropath | 2015 |
Effects of two antioxidants; α-lipoic acid and fisetin against diabetic cataract in mice.
Topics: Animals; Antioxidants; Cataract; Diabetes Complications; Diabetes Mellitus, Experimental; Disease Pr | 2015 |
Oxidative stress and light-evoked responses of the posterior segment in a mouse model of diabetic retinopathy.
Topics: Animals; Antioxidants; Choroid; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Female; Light | 2015 |
Andrographolide derivative AL-1 improves insulin resistance through down-regulation of NF-κB signalling pathway.
Topics: Andrographis; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diterpenes; Dose- | 2015 |
[Anxiolytic and antidepressant effects of 3-oxypiridine and succinic acid derivatives in alloxan diabetes].
Topics: Animals; Anti-Anxiety Agents; Anxiety; Depression; Diabetes Mellitus, Experimental; Humans; Hypergly | 2015 |
Huangkui capsule attenuates renal fibrosis in diabetic nephropathy rats through regulating oxidative stress and p38MAPK/Akt pathways, compared to α-lipoic acid.
Topics: Abelmoschus; Animals; Antioxidants; Capsules; Diabetes Mellitus, Experimental; Diabetic Nephropathie | 2015 |
Effect of combination therapy consisting of enalapril, α-lipoic acid, and menhaden oil on diabetic neuropathy in a high fat/low dose streptozotocin treated rat.
Topics: Animals; Cornea; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Neuropathies; | 2015 |
Effect of Lipoic Acid on Serum Paraoxonase-1 and Paraoxonase-3 Protein Levels and Activities in Diabetic Rats.
Topics: Animals; Aryldialkylphosphatase; Diabetes Mellitus, Experimental; Male; Random Allocation; Rats; Rat | 2019 |
Effects of alpha-lipoic acid on retinal ganglion cells, retinal thicknesses, and VEGF production in an experimental model of diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Male; Mice, Inbred BAL | 2017 |
Effects of troxerutin on cognitive deficits and glutamate cysteine ligase subunits in the hippocampus of streptozotocin-induced type 1 diabetes mellitus rats.
Topics: Animals; Cognition Disorders; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Drug Evalu | 2017 |
Early vs. late intervention of high fat/low dose streptozotocin treated C57Bl/6J mice with enalapril, α-lipoic acid, menhaden oil or their combination: Effect on diabetic neuropathy related endpoints.
Topics: Acute Disease; Animals; Chronic Disease; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dru | 2017 |
Effects of Lipoic Acid Supplementation on Activities of Cyclooxygenases and Levels of Prostaglandins E
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dinoprost; Dinoprostone; Disea | 2016 |
Tang-Luo-Ning Improves Mitochondrial Antioxidase Activity in Dorsal Root Ganglia of Diabetic Rats: A Proteomics Study.
Topics: Animals; Blood Glucose; Chromatography, Ion Exchange; Diabetes Mellitus, Experimental; Disease Model | 2017 |
Early lipoic acid intake protects retina of diabetic mice.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Drug Administration Sc | 2008 |
Coenzyme Q(10) and alpha-lipoic acid supplementation in diabetic rats: conduction velocity distributions.
Topics: Action Potentials; Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimenta | 2008 |
Chronic lipoic acid treatment worsens energy imbalances in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Body Composition; Body Weight; Diabetes Mellitus, Experimental; Eating; Ener | 2009 |
Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats.
Topics: Animals; Aorta, Thoracic; Ascorbic Acid; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental | 2009 |
Alpha-lipoic acid reduces congenital malformations in the offspring of diabetic mice.
Topics: Animals; Blood Glucose; Cardiovascular Abnormalities; Congenital Abnormalities; Diabetes Mellitus, E | 2009 |
Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment.
Topics: Alloxan; Animals; Blood Glucose; Cytoprotection; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2009 |
[Expressions of NOS isoforms in the cavernous tissues of diabetic rat models].
Topics: Animals; Diabetes Mellitus, Experimental; Erectile Dysfunction; Insulin; Male; Nitric Oxide Synthase | 2009 |
[Effects of alpha lipoic acid on hypothalamus-pituitary-adrenal axis in rats].
Topics: Animals; Diabetes Mellitus, Experimental; Hypothalamo-Hypophyseal System; Male; Pituitary-Adrenal Sy | 2010 |
Protective effects of irbesartan and alpha lipoic acid in STZ-induced diabetic nephropathy in rats.
Topics: Animals; Biphenyl Compounds; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Female; Immuno | 2010 |
Acute exercise and thioredoxin-1 in rat brain, and alpha-lipoic acid and thioredoxin-interacting protein response, in diabetes.
Topics: Animals; Antioxidants; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Glutathione; Glutathio | 2010 |
Alpha-lipoic acid does not alter stress protein response to acute exercise in diabetic brain.
Topics: Animals; Antioxidants; Brain; Diabetes Mellitus, Experimental; HSP70 Heat-Shock Proteins; HSP90 Heat | 2010 |
Testicular oxidative damage and role of combined antioxidant supplementation in experimental diabetic rats.
Topics: Animals; Antioxidants; Apoptosis; Ascorbic Acid; Caspase 3; Diabetes Mellitus, Experimental; Dietary | 2011 |
α-Lipoic acid normalizes nociceptive neuronal activity at the spinal cord of diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Male; Nociceptors; Oxidative Stress; Rats; R | 2011 |
Alpha lipoic acid treatment improved endothelium-dependent relaxation in diabetic rat aorta.
Topics: Animals; Antioxidants; Aorta; Diabetes Mellitus, Experimental; Endothelium, Vascular; In Vitro Techn | 2011 |
[Extract of Ginkgo biloba and alpha-lipoic acid attenuate advanced glycation end products accumulation and RAGE expression in diabetic nephropathy rats].
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Ginkgo biloba; Glyca | 2011 |
Palladium-α-lipoic acid complex attenuates alloxan-induced hyperglycemia and enhances the declined blood antioxidant status in diabetic rats.
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Glutathion | 2011 |
[Cerebroprotective effect of 3-oxypyridine and succinic acid derivatives in acute phase of alloxan-induced diabetes mellitus in rats].
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Anim | 2011 |
The potential role of combined antioxidant treatment on pancreas of STZ-diabetic mice.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, D | 2013 |
Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Disease Progression; D | 2011 |
Changes in expression profiles of antioxidant enzymes in diabetic rat kidneys.
Topics: Animals; Antioxidants; Ascorbic Acid; Catalase; Diabetes Mellitus, Experimental; Drug Combinations; | 2012 |
Suppression of high pacing-induced ANP secretion by antioxidants in isolated rat atria.
Topics: Acetophenones; Acetylcysteine; Animals; Antioxidants; Atrial Function; Atrial Natriuretic Factor; Bl | 2011 |
Alpha-lipoic acid preserves the structural and functional integrity of red blood cells by adjusting the redox disturbance and decreasing O-GlcNAc modifications of antioxidant enzymes and heat shock proteins in diabetic rats.
Topics: Acetylglucosamine; Animals; Antioxidants; Catalase; Diabetes Mellitus, Experimental; Electrophoresis | 2012 |
[Antihypoxic effect of 3-hydroxypyridine and succinic acid derivatives and their nootropic action in alloxan diabetes].
Topics: Alloxan; Animals; Conditioning, Classical; Diabetes Mellitus, Experimental; Diabetic Neuropathies; D | 2011 |
α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase.
Topics: AMP-Activated Protein Kinases; Animals; Cell Line; Diabetes Mellitus, Experimental; Lipid Metabolism | 2012 |
Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid.
Topics: Actins; Animals; Blotting, Western; Cardiac Catheterization; Cardiotonic Agents; Cell Differentiatio | 2012 |
Topical treatment with anti-oxidants and Au nanoparticles promote healing of diabetic wound through receptor for advance glycation end-products.
Topics: Administration, Topical; Animals; Antioxidants; Catechin; Cell Line; Diabetes Mellitus, Experimental | 2012 |
Alpha-lipoic acid upregulates antioxidant enzyme gene expression and enzymatic activity in diabetic rat kidneys through an O-GlcNAc-dependent mechanism.
Topics: Acetylglucosamine; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; | 2013 |
Effects of lipoic acid in an experimentally induced hypertensive and diabetic rat model.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Hypertensi | 2013 |
Decreased O-GlcNAcylation of the key proteins in kinase and redox signalling pathways is a novel mechanism of the beneficial effect of α-lipoic acid in diabetic liver.
Topics: Aminoacylation; Animals; Antioxidants; Catalase; CCAAT-Binding Factor; Diabetes Mellitus, Experiment | 2013 |
Effects of alpha lipoic acid, ascorbic acid-6-palmitate, and fish oil on the glutathione, malonaldehyde, and fatty acids levels in erythrocytes of streptozotocin induced diabetic male rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Cholesterol; Diabetes Mellitus, Experimental; Erythrocyte Memb | 2002 |
Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.
Topics: alpha-Tocopherol; Animals; Antioxidants; Blood Flow Velocity; Diabetes Mellitus, Experimental; Diabe | 2003 |
Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production.
Topics: Animals; Antioxidants; Blood Pressure; Body Weight; Diabetes Mellitus, Experimental; Glucose; Glycat | 2003 |
Preventing superoxide formation in epineurial arterioles of the sciatic nerve from diabetic rats restores endothelium-dependent vasodilation.
Topics: Animals; Arginine; Arterioles; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Diabetic Neuropathi | 2003 |
Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Diabete | 2003 |
Effects of alpha-lipoic acid on impaired gastric fundus innervation in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Gastric Fundus; In Vitro Techniques; Injections, Intraperi | 2003 |
[Clinical and experimental aspects of thioctic acid].
Topics: Acids; Animals; Diabetes Mellitus, Experimental; Glycosides; Lipid Metabolism; Liver Diseases; Thioc | 1955 |
Alpha-lipoic acid treatment prevents the diabetes-induced attenuation of the afferent limb of the baroreceptor reflex in rats.
Topics: Afferent Pathways; Animals; Baroreflex; Diabetes Mellitus, Experimental; Genes, fos; Male; Malondial | 2003 |
Antioxidative treatment reverses imbalances of nitric oxide synthase isoform expression and attenuates tissue-cGMP activation in diabetic rats.
Topics: Animals; Antioxidants; Apoptosis; Blood Glucose; Cyclic GMP; Diabetes Mellitus, Experimental; DNA Pr | 2004 |
Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with alpha-lipoic acid and evening primrose oil.
Topics: Animals; Calcitonin Gene-Related Peptide; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dr | 2004 |
alpha-Lipoic acid ameliorates altered colonic contractility and intestinal transit in STZ-diabetic rats.
Topics: Acetylcholine; Animals; Antioxidants; Body Weight; Colon; Diabetes Mellitus, Experimental; Female; I | 2004 |
[Effects of DL-alpha-lipoic acid on the experimentally induced diabetic cataract in rats].
Topics: Animals; Antioxidants; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; Disease Models, Ani | 2004 |
Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, E | 2004 |
Effects of alpha-lipoic acid supplementation on maternal diabetes-induced growth retardation and congenital anomalies in rat fetuses.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Bone Development; Diabetes Mellitus, Experimental | 2004 |
Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes.
Topics: Animals; Antioxidants; Biomarkers; Brain Chemistry; Diabetes Mellitus, Experimental; Diabetic Neurop | 2004 |
Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats.
Topics: Animals; Cell Death; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Male; Oxidative Stress; | 2004 |
Influence of treatment of diabetic rats with combinations of pycnogenol, beta-carotene, and alpha-lipoic acid on parameters of oxidative stress.
Topics: Animals; Antioxidants; beta Carotene; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Fe | 2004 |
Effects of antioxidant treatment on normal and diabetic rat retinal enzyme activities.
Topics: Animals; Antioxidants; beta Carotene; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Drug Co | 2005 |
Mechanisms of antioxidant and pro-oxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidney.
Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephrop | 2005 |
Pretreatment of diabetic rats with lipoic acid improves healing of subsequently-induced abrasion wounds.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Endothelial Cells; Fibroblasts | 2005 |
Effects of triple antioxidant combination (vitamin E, vitamin C and alpha-lipoic acid) with insulin on lipid and cholesterol levels and fatty acid composition of brain tissue in experimental diabetic and non-diabetic rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Brain; Cholesterol; Diabetes Mellitus, Experimental; Fatty Aci | 2005 |
The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats.
Topics: Animals; Antioxidants; Diabetes Complications; Diabetes Mellitus, Experimental; Erectile Dysfunction | 2005 |
Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Male; NF-kappa B; Rats; Rats, Wistar | 2006 |
Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: prevention by lipoic acid treatment.
Topics: Animals; Antioxidants; Cell Count; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Male; Mi | 2006 |
alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet.
Topics: Animals; Antioxidants; Apolipoproteins E; Aryldialkylphosphatase; Atherosclerosis; Biomarkers; Blood | 2006 |
alpha-lipoic acid corrects late-phase supernormal retinal oxygenation response in experimental diabetic retinopathy.
Topics: Animals; Antioxidants; Carbon Dioxide; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Hypero | 2006 |
Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes.
Topics: Animals; Antioxidants; Blotting, Western; Carrier Proteins; Cell Cycle Proteins; Cells, Cultured; Di | 2006 |
At low doses, a gamma-linolenic acid-lipoic acid conjugate is more effective than docosahexaenoic acid-enriched phospholipids in preventing neuropathy in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Docosahexaenoic Acids; Dose-Respons | 2007 |
Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney.
Topics: Analysis of Variance; Animals; Blotting, Western; Diabetes Mellitus, Experimental; Diabetic Nephropa | 2007 |
Impaired apparent ion demand in experimental diabetic retinopathy: correction by lipoic Acid.
Topics: Animals; Antioxidants; Blood-Retinal Barrier; Capillary Permeability; Diabetes Mellitus, Experimenta | 2007 |
Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats.
Topics: Aging; Animals; Antioxidants; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2008 |
Effect of vitamin C and lipoic acid on streptozotocin-induced diabetes gene expression: mRNA and protein expressions of Cu-Zn SOD and catalase.
Topics: Actins; Animals; Antioxidants; Ascorbic Acid; Blotting, Western; Catalase; Densitometry; Diabetes Me | 2008 |
Lipoic acid ameliorates oxidative stress and renal injury in alloxan diabetic rabbits.
Topics: Animals; Antioxidants; Blood Glucose; Creatine; Diabetes Mellitus, Experimental; Diabetic Nephropath | 2008 |
Ability of alpha-lipoic acid to reverse the diabetic cystopathy in a rat model.
Topics: Animals; Antioxidants; Catalase; Diabetes Complications; Diabetes Mellitus, Experimental; Male; Malo | 2008 |
Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Ganglia, Spinal; Glutathione; Human | 1995 |
Effect of lipoic acid on cyclophosphamide-induced diabetes and insulitis in non-obese diabetic mice.
Topics: Animals; Antioxidants; Cyclophosphamide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 1994 |
The influence of thioctic acid on metabolism and function of the diabetic heart.
Topics: Adenosine Triphosphate; Animals; Cardiac Output; Cardiomyopathies; Diabetes Mellitus, Experimental; | 1995 |
Modelling cortical cataractogenesis 17: in vitro effect of a-lipoic acid on glucose-induced lens membrane damage, a model of diabetic cataractogenesis.
Topics: Animals; Cataract; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucose; In Vitr | 1995 |
alpha-Lipoic acid corrects neuropeptide deficits in diabetic rats via induction of trophic support.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Nerve Growth Factors; Neuropeptide Y; Neuropeptides; | 1997 |
Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Deoxyglucose; Diabetes Mellitus, Experimental; Glucose Transporter Type 4; I | 1997 |
Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; gamma-L | 1998 |
A lipoic acid-gamma linolenic acid conjugate is effective against multiple indices of experimental diabetic neuropathy.
Topics: Animals; Antioxidants; Butylated Hydroxytoluene; Diabetes Mellitus, Experimental; Diabetic Neuropath | 1998 |
Metabolic effects of thioctic acid in rodent models of insulin resistance and diabetes.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Disease Models, Animal; Fructose; Glucose; H | 1998 |
Diabetes-induced changes in lens antioxidant status, glucose utilization and energy metabolism: effect of DL-alpha-lipoic acid.
Topics: Adenine Nucleotides; Animals; Antioxidants; Diabetes Mellitus, Experimental; Energy Metabolism; Fruc | 1998 |
Lipoic acid prevention of neural tube defects in offspring of rats with streptozocin-induced diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Neural Tube Defects; Placenta; Pregnancy; Pregnanc | 1999 |
Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats.
Topics: Acetylcholine; Animals; Antioxidants; Atropine; Blood Glucose; Body Weight; Diabetes Mellitus, Exper | 1999 |
Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats.
Topics: 3-Hydroxybutyric Acid; Alanine; Animals; Blood Glucose; Carnitine; Diabetes Mellitus, Experimental; | 1999 |
Nerve conduction impairment in experimental diabetes-proximodistal gradient of severity.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Combinations; Enzyme Inhibitors; gamma-Linolenic Acid | 1999 |
Alpha-lipoic acid: effect on glucose uptake, sorbitol pathway, and energy metabolism in experimental diabetic neuropathy.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relati | 1999 |
Effect of alpha-lipoic acid supplementation on oxidative protein damage in the streptozotocin-diabetic rat.
Topics: Analysis of Variance; Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Free Radical | 2000 |
Early changes in lipid peroxidation and antioxidative defense in diabetic rat retina: effect of DL-alpha-lipoic acid.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; Glucose; Glutathione; Glutathio | 2000 |
Effects of DL-alpha-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Energy Metabolism; Enz | 2000 |
Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus.
Topics: Animals; Antioxidants; Collagen; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dietary Su | 2001 |
The effect of gamma-linolenic acid-alpha-lipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Brain; Central Nervous System; Diabetes Mellitus, Experimental; | 2001 |
Alpha-lipoic acid treatment ameliorates metabolic parameters, blood pressure, vascular reactivity and morphology of vessels already damaged by streptozotocin-diabetes.
Topics: Animals; Antioxidants; Aorta; Blood Pressure; Carbohydrate Metabolism; Diabetes Mellitus, Experiment | 2000 |
Metabolic effects of gamma-linolenic acid-alpha-lipoic acid conjugate in streptozotocin diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Electrophoresis, Polyacrylami | 1999 |
Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy.
Topics: Adrenergic alpha-Antagonists; Ammonia; Animals; Antioxidants; Cell Fractionation; Diabetes Mellitus, | 2001 |
Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; gamma-Linolenic Acid; Male; Nerve G | 2001 |
Glutathione and alpha-lipoate in diabetic rats: nerve function, blood flow and oxidative state.
Topics: Animals; Antioxidants; Blood Flow Velocity; Diabetes Mellitus, Experimental; Diabetic Neuropathies; | 2001 |
Effect of alpha-lipoic acid on vascular responses and nociception in diabetic rats.
Topics: Animals; Antioxidants; Blood Flow Velocity; Diabetes Mellitus, Experimental; Endothelium, Vascular; | 2001 |
Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve.
Topics: Animals; Antioxidants; Aorta; Arterioles; Diabetes Mellitus, Experimental; Dietary Supplements; Inos | 2001 |
The effects of treatment with alpha-lipoic acid or evening primrose oil on vascular hemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat.
Topics: Animals; Blood Circulation; Cholesterol; Diabetes Mellitus, Experimental; Fatty Acids, Essential; ga | 2001 |
Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats.
Topics: Alternative Splicing; Animals; Antioxidants; Ascorbic Acid; Blood Glucose; Dehydroascorbic Acid; Dia | 2001 |
Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes.
Topics: Albuminuria; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephrop | 2002 |
Neuronal death in the rat hippocampus in experimental diabetes and cerebral ischaemia treated with antioxidants.
Topics: Animals; Antioxidants; Apoptosis; Blood Glucose; Brain Ischemia; Caspase 3; Caspases; Cell Count; Co | 2001 |
Elimination of *O(2)(-)/H(2)O(2) by alpha-lipoic acid mediates the recovery of basal EDRF/NO availability and the reversal of superoxide dismutase-induced relaxation in diabetic rat aorta.
Topics: Amitrole; Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus, Experim | 2002 |
Effect of alpha-lipoic acid on lipid peroxidation and anti-oxidant enzyme activities in diabetic rats.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Enzyme Activation; Glutathione Peroxidase; G | 2002 |
Effect of DL-alpha-lipoic acid on the citrate concentration and phosphofructokinase activity of perfused hearts from normal and diabetic rats.
Topics: Animals; Caprylates; Citrates; Coenzyme A; Diabetes Mellitus, Experimental; Glucose; Glycogen; Heart | 1970 |