thioctic acid has been researched along with Allergic Encephalomyelitis in 14 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We performed serum pharmacokinetic studies in patients with multiple sclerosis after a single oral dose of 1200 mg lipoic acid." | 2.75 | Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters. ( Alvarez, L; Bourdette, DN; Cherala, G; Koop, DR; Marracci, GH; Munar, MY; Shinto, L; Stuber, LE; Yadav, V, 2010) |
| "Central neuropathic pain is a common untreated symptom in progressive multiple sclerosis (PMS) and is associated with poor quality of life and interference with patients' daily activities." | 1.56 | Nociception in a Progressive Multiple Sclerosis Model in Mice Is Dependent on Spinal TRPA1 Channel Activation. ( Antoniazzi, CT; Dalenogare, DP; de Almeida, AS; Ferreira, J; Fialho, MFP; Kudsi, SQ; Lückemeyer, DD; Oliveira, SM; Pereira, GC; Pereira, VL; Ritter, C; Trevisan, G, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 7 (50.00) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Xie, H | 1 |
| Yang, X | 1 |
| Cao, Y | 1 |
| Long, X | 1 |
| Shang, H | 1 |
| Jia, Z | 1 |
| Ritter, C | 1 |
| Dalenogare, DP | 1 |
| de Almeida, AS | 1 |
| Pereira, VL | 1 |
| Pereira, GC | 1 |
| Fialho, MFP | 1 |
| Lückemeyer, DD | 1 |
| Antoniazzi, CT | 1 |
| Kudsi, SQ | 1 |
| Ferreira, J | 1 |
| Oliveira, SM | 1 |
| Trevisan, G | 1 |
| Dietrich, M | 1 |
| Helling, N | 1 |
| Hilla, A | 1 |
| Heskamp, A | 1 |
| Issberner, A | 1 |
| Hildebrandt, T | 1 |
| Kohne, Z | 1 |
| Küry, P | 1 |
| Berndt, C | 1 |
| Aktas, O | 1 |
| Fischer, D | 1 |
| Hartung, HP | 1 |
| Albrecht, P | 1 |
| Evans, E | 1 |
| Piccio, L | 1 |
| Cross, AH | 1 |
| Li, B | 1 |
| Tan, GJ | 1 |
| Lin, HQ | 1 |
| Zhang, JN | 1 |
| Guo, L | 1 |
| Chen, LP | 1 |
| Wang, KC | 1 |
| Tsai, CP | 1 |
| Lee, CL | 1 |
| Chen, SY | 1 |
| Lin, GJ | 1 |
| Yen, MH | 1 |
| Sytwu, HK | 1 |
| Chen, SJ | 1 |
| Chaudhary, P | 3 |
| Marracci, G | 2 |
| Galipeau, D | 2 |
| Pocius, E | 1 |
| Morris, B | 2 |
| Bourdette, D | 2 |
| Yadav, V | 1 |
| Marracci, GH | 3 |
| Munar, MY | 1 |
| Cherala, G | 1 |
| Stuber, LE | 1 |
| Alvarez, L | 1 |
| Shinto, L | 1 |
| Koop, DR | 1 |
| Bourdette, DN | 3 |
| Yu, X | 1 |
| Jones, RE | 2 |
| McKeon, GP | 1 |
| Morini, M | 1 |
| Roccatagliata, L | 1 |
| Dell'Eva, R | 1 |
| Pedemonte, E | 1 |
| Furlan, R | 1 |
| Minghelli, S | 1 |
| Giunti, D | 1 |
| Pfeffer, U | 1 |
| Marchese, M | 1 |
| Noonan, D | 1 |
| Mancardi, G | 1 |
| Albini, A | 1 |
| Uccelli, A | 1 |
| Schreibelt, G | 1 |
| Musters, RJ | 1 |
| Reijerkerk, A | 1 |
| de Groot, LR | 1 |
| van der Pol, SM | 1 |
| Hendrikx, EM | 1 |
| Döpp, ED | 1 |
| Dijkstra, CD | 1 |
| Drukarch, B | 1 |
| de Vries, HE | 1 |
| Moes, N | 1 |
| Zwickey, H | 1 |
| Cunningham, CL | 1 |
| Gregory, WL | 1 |
| Oken, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial.[NCT04284059] | Phase 4 | 504 participants (Anticipated) | Interventional | 2021-02-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thioctic acid and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Role of lipoic acid in multiple sclerosis.
Topics: Animals; Antioxidants; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Humans; | 2022 |
Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review.
Topics: Acetylcarnitine; Animals; Ascorbic Acid; Biotin; Caffeine; Creatine; Curcumin; Dietary Supplements; | 2018 |
1 trial available for thioctic acid and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters.
Topics: Administration, Oral; Adult; Aged; Animals; Antioxidants; Area Under Curve; Biological Availability; | 2010 |
11 other studies available for thioctic acid and Allergic Encephalomyelitis
| Article | Year |
|---|---|
Nociception in a Progressive Multiple Sclerosis Model in Mice Is Dependent on Spinal TRPA1 Channel Activation.
Topics: Acetanilides; Acetophenones; Analgesics; Animals; Antipyrine; Dipyrone; Encephalomyelitis, Autoimmun | 2020 |
Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model.
Topics: Animals; CD3 Complex; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; G | 2018 |
Neuroprotective effects of α-lipoic acid on long-term experimental autoimmune encephalomyelitis.
Topics: Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents; Antioxidants; Encephalomyelitis, | 2018 |
α-Lipoic acid enhances endogenous peroxisome-proliferator-activated receptor-γ to ameliorate experimental autoimmune encephalomyelitis in mice.
Topics: Animals; Antioxidants; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; He | 2013 |
Lipoic acid reduces inflammation in a mouse focal cortical experimental autoimmune encephalomyelitis model.
Topics: Animals; Antioxidants; CD11b Antigen; Cerebral Cortex; Cytokines; Disease Models, Animal; Encephalit | 2015 |
Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Inflammation M | 2011 |
Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis.
Topics: Acute Disease; Animals; Antioxidants; Cell Movement; Cells, Cultured; Encephalomyelitis, Autoimmune, | 2002 |
Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis.
Topics: Analysis of Variance; Animals; Antioxidants; Cell Line, Tumor; Dose-Response Relationship, Drug; Enc | 2004 |
Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis.
Topics: Animals; Cell Migration Inhibition; Down-Regulation; Encephalomyelitis, Autoimmune, Experimental; En | 2006 |
Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity.
Topics: Acute Disease; Animals; Antioxidants; Blood-Brain Barrier; Brain; Capillary Permeability; Cell Line, | 2006 |
Treatment of experimental autoimmune encephalomyelitis with alpha lipoic acid and associative conditioning.
Topics: Animals; Antioxidants; Association Learning; Combined Modality Therapy; Conditioning, Psychological; | 2008 |