thioctic acid has been researched along with Alkaptonuria in 2 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Alkaptonuria: An inborn error of amino acid metabolism resulting from a defect in the enzyme HOMOGENTISATE 1,2-DIOXYGENASE, an enzyme involved in the breakdown of PHENYLALANINE and TYROSINE. It is characterized by accumulation of HOMOGENTISIC ACID in the urine, OCHRONOSIS in various tissues, and ARTHRITIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This leads to the accumulation of homogentisic acid (HGA) and its oxidized/polymerized products in connective tissues, which in turn become characterized by the presence of melanin-like pigments (ochronosis)." | 3.76 | Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis. ( Amato, L; Bernardini, G; Braconi, D; Cavallo, G; Laschi, M; Marcolongo, R; Millucci, L; Santucci, A; Spreafico, A, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spreafico, A | 2 |
| Millucci, L | 2 |
| Ghezzi, L | 1 |
| Geminiani, M | 1 |
| Braconi, D | 2 |
| Amato, L | 2 |
| Chellini, F | 1 |
| Frediani, B | 1 |
| Moretti, E | 1 |
| Collodel, G | 1 |
| Bernardini, G | 2 |
| Santucci, A | 2 |
| Laschi, M | 1 |
| Marcolongo, R | 1 |
| Cavallo, G | 1 |
2 other studies available for thioctic acid and Alkaptonuria
| Article | Year |
|---|---|
Antioxidants inhibit SAA formation and pro-inflammatory cytokine release in a human cell model of alkaptonuria.
Topics: Acetylcysteine; Alkaptonuria; Antioxidants; Ascorbic Acid; Cell Line; Chondrocytes; Cytokines; Human | 2013 |
Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis.
Topics: Acetylcysteine; Alkaptonuria; Antioxidants; Ascorbic Acid; Cells, Cultured; Coumaric Acids; Homogent | 2010 |