thioctic acid has been researched along with Aging in 111 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Co-supplementation of lipoic acid with carnitine has a beneficial effect in reversing the age-related abnormalities seen in aging." | 7.73 | Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine. ( Anusuyadevi, M; Panneerselvam, C; Savitha, S; Tamilselvan, J, 2005) |
| "N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes." | 7.69 | Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997) |
| "D-galactose (D-gal) -induced aging models in Drosophila, houseflies, mice and rats have been widely used; however, the underlying mechanisms are poorly understood." | 3.74 | D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. ( Cui, X; Gao, H; Liu, C; Liu, J; Liu, Z; Long, J; Miao, M; Packer, L; Wang, X, 2007) |
| " In parallel, we have also investigated the levels of carnitine and lipoic acid during aging." | 3.74 | Carnitine and lipoate ameliorates lipofuscin accumulation and monoamine oxidase activity in aged rat heart. ( Naveen, B; Panneerselvam, C; Savitha, S, 2007) |
| "Co-supplementation of lipoic acid with carnitine has a beneficial effect in reversing the age-related abnormalities seen in aging." | 3.73 | Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine. ( Anusuyadevi, M; Panneerselvam, C; Savitha, S; Tamilselvan, J, 2005) |
| "Chronic systemic exposure of mice, rats, and Drosophila to D-galactose causes the acceleration of senescence and has been used as an aging model." | 3.73 | Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. ( Cui, X; Hu, Y; Li, X; Liu, J; Long, J; Packer, L; Zhang, Q; Zuo, P, 2006) |
| "N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes." | 3.69 | Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997) |
| "Reactive hyperemia was reduced with age, but antioxidant administration did not alter the response in either group." | 2.77 | Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption. ( Barrett-O'Keefe, Z; Fjeldstad, AS; Harris, RA; Ives, SJ; McDaniel, J; Nishiyama, SK; Richardson, RS; Witman, MA; Wray, DW; Zhao, J, 2012) |
| "The aging risk factor for Parkinson's disease is described in terms of specific disease markers including mitochondrial and gene dysfunctions relevant to energy metabolism." | 2.50 | Management of the aging risk factor for Parkinson's disease. ( Phillipson, OT, 2014) |
| " Improved endothelial function due to alpha-LA was at least partially attributed to recoupling of eNOS and increased NO bioavailability and represents a pharmacological approach to prevent major complications associated with type 2 diabetes." | 1.35 | Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats. ( Boarder, MR; Fernandes, R; Louro, T; Nunes, E; Proença, T; Seiça, RM; Sena, CM, 2008) |
| "Oxidative stress may play a key role in Alzheimer's disease (AD) neuropathology." | 1.34 | Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. ( Bussiere, JR; Hammond, RS; Henson, E; Jones, RE; Montine, TJ; Quinn, JF; Stackman, RW, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.90) | 18.7374 |
| 1990's | 6 (5.41) | 18.2507 |
| 2000's | 68 (61.26) | 29.6817 |
| 2010's | 33 (29.73) | 24.3611 |
| 2020's | 3 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Dos Santos, SM | 1 |
| Romeiro, CFR | 1 |
| Rodrigues, CA | 1 |
| Cerqueira, ARL | 1 |
| Monteiro, MC | 1 |
| Zhang, P | 1 |
| Edgar, BA | 1 |
| Pagano, G | 1 |
| Pallardó, FV | 1 |
| Lyakhovich, A | 1 |
| Tiano, L | 1 |
| Fittipaldi, MR | 1 |
| Toscanesi, M | 1 |
| Trifuoggi, M | 1 |
| Behnamifar, A | 1 |
| Rahimi, S | 1 |
| Karimi Torshizi, MA | 1 |
| Sharafi, M | 1 |
| Grimes, JL | 1 |
| Nobakht-Haghighi, N | 1 |
| Rahimifard, M | 1 |
| Baeeri, M | 1 |
| Rezvanfar, MA | 1 |
| Moini Nodeh, S | 1 |
| Haghi-Aminjan, H | 1 |
| Hamurtekin, E | 1 |
| Abdollahi, M | 1 |
| Molinari, C | 1 |
| Morsanuto, V | 1 |
| Ghirlanda, S | 1 |
| Ruga, S | 1 |
| Notte, F | 1 |
| Gaetano, L | 1 |
| Uberti, F | 1 |
| Jiang, T | 1 |
| Yin, F | 1 |
| Yao, J | 1 |
| Brinton, RD | 1 |
| Cadenas, E | 1 |
| Lu, C | 1 |
| Kim, BM | 1 |
| Lee, D | 1 |
| Lee, MH | 1 |
| Kim, JH | 1 |
| Pyo, HB | 1 |
| Chai, KY | 1 |
| Phillipson, OT | 1 |
| Thakurta, IG | 1 |
| Banerjee, P | 1 |
| Bagh, MB | 2 |
| Ghosh, A | 1 |
| Sahoo, A | 1 |
| Chattopadhyay, S | 1 |
| Chakrabarti, S | 3 |
| Deslauriers, J | 1 |
| Racine, W | 1 |
| Sarret, P | 1 |
| Grignon, S | 1 |
| Ma, QL | 1 |
| Zuo, X | 1 |
| Yang, F | 1 |
| Ubeda, OJ | 1 |
| Gant, DJ | 1 |
| Alaverdyan, M | 1 |
| Kiosea, NC | 1 |
| Nazari, S | 1 |
| Chen, PP | 1 |
| Nothias, F | 1 |
| Chan, P | 1 |
| Teng, E | 1 |
| Frautschy, SA | 1 |
| Cole, GM | 1 |
| Keith, D | 1 |
| Finlay, L | 1 |
| Butler, J | 1 |
| Gómez, L | 1 |
| Smith, E | 1 |
| Moreau, R | 4 |
| Hagen, T | 1 |
| Patel, MK | 1 |
| Riley, MA | 1 |
| Hobbs, S | 1 |
| Cortez-Cooper, M | 1 |
| Robinson, VJ | 1 |
| Zhao, L | 1 |
| Hu, FX | 1 |
| Moura, FA | 1 |
| de Andrade, KQ | 1 |
| dos Santos, JC | 1 |
| Goulart, MO | 1 |
| Skibska, B | 1 |
| Goraca, A | 1 |
| Sinha, M | 1 |
| Bir, A | 1 |
| Banerjee, A | 1 |
| Bhowmick, P | 1 |
| Snigdha, S | 1 |
| de Rivera, C | 2 |
| Milgram, NW | 4 |
| Cotman, CW | 4 |
| Mahmoud, YI | 1 |
| Hegazy, HG | 1 |
| Nebbioso, M | 1 |
| Scarsella, G | 1 |
| Librando, A | 1 |
| Pescosolido, N | 1 |
| Sikora, V | 1 |
| Bojko, V | 1 |
| Tkach, G | 1 |
| Kyptenko, L | 1 |
| Lyndin, M | 1 |
| Williams, CA | 2 |
| Hall, JA | 2 |
| Yerramilli, M | 2 |
| Obare, E | 1 |
| Panickar, KS | 1 |
| Bobe, G | 1 |
| Jewell, DE | 3 |
| Maiti, AK | 1 |
| Roy, A | 1 |
| McCarty, MF | 1 |
| Barroso-Aranda, J | 1 |
| Contreras, F | 1 |
| Gan, L | 1 |
| von Moltke, LL | 1 |
| Trepanier, LA | 1 |
| Harmatz, JS | 1 |
| Greenblatt, DJ | 1 |
| Court, MH | 1 |
| Long, J | 3 |
| Gao, F | 1 |
| Tong, L | 1 |
| Ames, BN | 7 |
| Liu, J | 9 |
| Shay, KP | 2 |
| Hagen, TM | 15 |
| Singh, U | 1 |
| Jialal, I | 1 |
| Shenk, JC | 2 |
| Fischbach, K | 2 |
| Xu, K | 1 |
| Puchowicz, M | 1 |
| Obrenovich, ME | 2 |
| Gasimov, E | 2 |
| Alvarez, LM | 1 |
| Lamanna, JC | 1 |
| Aliev, G | 2 |
| Sudheesh, NP | 2 |
| Ajith, TA | 2 |
| Janardhanan, KK | 2 |
| Krishnan, CV | 2 |
| Bentov, Y | 1 |
| Esfandiari, N | 1 |
| Burstein, E | 1 |
| Casper, RF | 1 |
| Christie, LA | 1 |
| Opii, WO | 1 |
| Head, E | 2 |
| Araujo, JA | 1 |
| Wray, DW | 3 |
| Nishiyama, SK | 2 |
| Monnet, A | 1 |
| Wary, C | 1 |
| Duteil, SS | 1 |
| Carlier, PG | 1 |
| Richardson, RS | 3 |
| Donato, AJ | 1 |
| Uberoi, A | 1 |
| Bailey, DM | 1 |
| Wang, Y | 1 |
| Li, X | 2 |
| Guo, Y | 1 |
| Chan, L | 1 |
| Guan, X | 1 |
| Graf, J | 1 |
| Bitar, MS | 1 |
| Ayed, AK | 1 |
| Abdel-Halim, SM | 1 |
| Isenovic, ER | 1 |
| Al-Mulla, F | 1 |
| Li, L | 1 |
| Smith, A | 1 |
| Frei, B | 4 |
| Monette, JS | 2 |
| Gómez, LA | 1 |
| Moreau, RF | 2 |
| Dunn, KC | 1 |
| Butler, JA | 2 |
| Finlay, LA | 2 |
| Michels, AJ | 2 |
| Smith, EJ | 2 |
| Palaniyappan, A | 1 |
| Alphonse, R | 1 |
| Petersen, SK | 1 |
| Harris, RA | 1 |
| Zhao, J | 1 |
| McDaniel, J | 1 |
| Fjeldstad, AS | 1 |
| Witman, MA | 1 |
| Ives, SJ | 1 |
| Barrett-O'Keefe, Z | 1 |
| Tsikas, D | 1 |
| Flentje, M | 1 |
| Niemann, J | 1 |
| Modun, D | 1 |
| Arivazhagan, P | 9 |
| Shila, S | 2 |
| Kumaran, S | 3 |
| Panneerselvam, C | 18 |
| Panneerselvam, SR | 1 |
| Heath, SH | 2 |
| Doneanu, CE | 1 |
| Lindsay, JG | 1 |
| Smith, AR | 2 |
| Suh, JH | 5 |
| Wang, H | 1 |
| Liu, RM | 2 |
| Shenvi, SV | 1 |
| Dixon, BM | 1 |
| Liu, H | 1 |
| Jaiswal, AK | 1 |
| Asghar, M | 1 |
| Lokhandwala, MF | 1 |
| Zicker, SC | 2 |
| Ikeda-Douglas, C | 1 |
| Murphey, H | 1 |
| Muggenberg, BA | 1 |
| Siwak, CT | 1 |
| Tapp, PD | 1 |
| Lowry, SR | 1 |
| Ikeda-Douglas, CJ | 1 |
| Estrada, J | 1 |
| Savitha, S | 6 |
| Anusuya Devi, M | 1 |
| Rosenfeldt, F | 1 |
| Miller, F | 1 |
| Nagley, P | 1 |
| Hadj, A | 1 |
| Marasco, S | 1 |
| Quick, D | 1 |
| Sheeran, F | 1 |
| Wowk, M | 1 |
| Pepe, S | 1 |
| Bastianetto, S | 1 |
| Quirion, R | 1 |
| Poon, HF | 1 |
| Farr, SA | 1 |
| Thongboonkerd, V | 1 |
| Lynn, BC | 1 |
| Banks, WA | 1 |
| Morley, JE | 1 |
| Klein, JB | 1 |
| Butterfield, DA | 1 |
| Park, SK | 1 |
| Prolla, TA | 1 |
| Tamilselvan, J | 3 |
| Anusuyadevi, M | 2 |
| Sivarajan, K | 4 |
| Haripriya, D | 1 |
| Kokilavani, V | 1 |
| Cakatay, U | 3 |
| Kayali, R | 3 |
| Panneerselvam, KS | 2 |
| Quinn, JF | 1 |
| Bussiere, JR | 1 |
| Hammond, RS | 1 |
| Montine, TJ | 1 |
| Henson, E | 1 |
| Jones, RE | 1 |
| Stackman, RW | 1 |
| Muthuswamy, AD | 1 |
| Vedagiri, K | 1 |
| Ganesan, M | 1 |
| Chinnakannu, P | 3 |
| Ayusawa, D | 1 |
| Cui, X | 2 |
| Zuo, P | 1 |
| Zhang, Q | 1 |
| Hu, Y | 1 |
| Packer, L | 2 |
| Sethumadhavan, S | 2 |
| Sundaram, K | 1 |
| Picton, RA | 1 |
| Finneran, PS | 1 |
| Bird, KE | 1 |
| Skinner, MM | 1 |
| Zicker, S | 1 |
| Brown, MK | 1 |
| Evans, JL | 1 |
| Luo, Y | 1 |
| Wang, X | 1 |
| Gao, H | 1 |
| Liu, Z | 1 |
| Liu, C | 1 |
| Miao, M | 1 |
| Palaniappan, AR | 1 |
| Dai, A | 1 |
| Kiziler, AR | 2 |
| Aydemir, B | 2 |
| Naveen, B | 1 |
| Sena, CM | 1 |
| Nunes, E | 1 |
| Louro, T | 1 |
| Proença, T | 1 |
| Fernandes, R | 1 |
| Boarder, MR | 1 |
| Seiça, RM | 1 |
| Jayaraman, G | 1 |
| Visioli, F | 2 |
| Pacheco, GJ | 1 |
| Chen, SG | 1 |
| Ward, WF | 1 |
| Richardson, AG | 1 |
| Smith, MA | 1 |
| Perry, G | 1 |
| Jacob, S | 1 |
| Henriksen, EJ | 1 |
| Schiemann, AL | 1 |
| Simon, I | 1 |
| Clancy, DE | 1 |
| Tritschler, HJ | 1 |
| Jung, WI | 1 |
| Augustin, HJ | 1 |
| Dietze, GJ | 1 |
| Stoll, S | 2 |
| Rostock, A | 1 |
| Bartsch, R | 1 |
| Korn, E | 1 |
| Meichelböck, A | 1 |
| Müller, WE | 2 |
| Hartmann, H | 1 |
| Cohen, SA | 1 |
| Schleicher, ED | 1 |
| Wagner, E | 1 |
| Nerlich, AG | 1 |
| Lykkesfeldt, J | 2 |
| Vinarsky, V | 3 |
| Ingersoll, RT | 1 |
| Wehr, CM | 2 |
| Bartholomew, JC | 1 |
| Ames, AB | 1 |
| Juliet, P | 1 |
| Seidman, MD | 1 |
| Khan, MJ | 1 |
| Bai, U | 1 |
| Shirwany, N | 1 |
| Quirk, WS | 1 |
| Shigeno, ET | 1 |
| Morrow, JD | 1 |
| Cox, B | 1 |
| Rocha, AE | 1 |
| Ramanathan, K | 2 |
| Bondy, SC | 1 |
| Yang, YE | 1 |
| Walsh, TJ | 1 |
| Gie, YW | 1 |
| Lahiri, DK | 1 |
| Lynch, MA | 1 |
| Killilea, DW | 1 |
| Hoffman, RM | 1 |
| Kronfeld, DS | 1 |
| Hess, TM | 1 |
| Saker, KE | 1 |
| Harris, PA | 1 |
| Bilska, A | 1 |
| Włodek, L | 1 |
| Kirk, JE | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Dose Finding and Tolerability Study of Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Peripheral Neuropathy[NCT01313117] | Phase 1/Phase 2 | 9 participants (Actual) | Interventional | 2012-02-29 | Completed | ||
| Exploratory Study of Lipoic Acid Supplementation on Oxidative Stress, Inflammatory and Functional Markers in Asthmatic Patients: Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial.[NCT01221350] | 55 participants (Actual) | Interventional | 2010-11-30 | Completed | |||
| The Effect of Concomitant Co Enzyme Q10 Use on Pregnancy Outcome of IVF[NCT01048385] | 34 participants (Actual) | Interventional | 2009-12-31 | Terminated (stopped due to A new study had shown that polar body biopsies might negatively effect the implantation potential of the embryo.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 9 |
Based on acceptable adverse event (AE) profile and continual reassessment method dose escalation. (NCT01313117)
Timeframe: 4 months
| Intervention | mg (Number) |
|---|---|
| Alpha Lipoic Acid | 500 |
(NCT01313117)
Timeframe: 4 months
| Intervention | participants (Number) |
|---|---|
| Alpha Lipoic Acid | 7 |
Proteins can become modified by a large number of reactions involving reactive oxygen species. Among these, carbonylation is an irreversible and unrepairable oxidative reaction. The main protein modifications originated from oxidative stress comprise direct oxidation of aminoacids with a thiol group, such as cysteine, oxidative glycation, and carbonylation. Oxidative protein carbonylation induce protein degradation in a nonspecific manner. Chemically, oxidative carbonylation preferentially occurs at proline, threonine, lysine, and arginine, presumably through a metal-catalyzed activation of hydrogen peroxide to a reactive intermediate. Carbonylation usually refers to a process that forms reactive ketones or aldehydes that can be reacted by 2,4-dinitrophenylhydrazine (DNPH) to form hydrazones. Direct oxidation of side chains of lysine, arginine, proline, and threonine residues, among other aminoacids, produces DNPH detectable protein products (NCT01221350)
Timeframe: Baseline
| Intervention | nmol/mg (Mean) |
|---|---|
| Lipoic Acid | 7.5 |
| Placebo | 10.12 |
Proteins can become modified by a large number of reactions involving reactive oxygen species. Among these, carbonylation is an irreversible and unrepairable oxidative reaction. The main protein modifications originated from oxidative stress comprise direct oxidation of aminoacids with a thiol group, such as cysteine, oxidative glycation, and carbonylation. Oxidative protein carbonylation induce protein degradation in a nonspecific manner. Chemically, oxidative carbonylation preferentially occurs at proline, threonine, lysine, and arginine, presumably through a metal-catalyzed activation of hydrogen peroxide to a reactive intermediate. Carbonylation usually refers to a process that forms reactive ketones or aldehydes that can be reacted by 2,4-dinitrophenylhydrazine (DNPH) to form hydrazones. Direct oxidation of side chains of lysine, arginine, proline, and threonine residues, among other aminoacids, produces DNPH detectable protein products. (NCT01221350)
Timeframe: 60 days
| Intervention | nmol/mg (Mean) |
|---|---|
| Lipoic Acid | 3.24 |
| Placebo | 4.21 |
Eosinophils, a prominent feature of asthma, are found in increased numbers in the circulation and sputum, usually in relation to the severity of asthma. (NCT01221350)
Timeframe: Baseline
| Intervention | Eosinophil percentage in sputum cells (Mean) |
|---|---|
| Lipoic Acid | 12.88 |
| Placebo | 6.10 |
Eosinophils, a prominent feature of asthma, are found in increased numbers in the circulation and sputum, usually in relation to the severity of asthma. (NCT01221350)
Timeframe: 60 days
| Intervention | Eosinophil percentage in sputum cells (Mean) |
|---|---|
| Lipoic Acid | 6.39 |
| Placebo | 5.68 |
Induced sputum of GSH and GSSG levels at baseline. The ratio GSH/GSSG is considered an index of antioxidant status and reductive -SH groups. GSH and GSSG were measured by a microplate fluorescent assay. (NCT01221350)
Timeframe: Baseline
| Intervention | ratio (Mean) |
|---|---|
| Lipoic Acid | 81.42 |
| Placebo | 35.77 |
Change in the induced sputum of antioxidant parameters GSH and GSSG levels after 60 days of treatment. The ratio GSH/GSSG is considered an index of antioxidant status and reductive -SH groups. GSH and GSSG were measured by a microplate fluorescent assay. (NCT01221350)
Timeframe: 60 days
| Intervention | ratio (Mean) |
|---|---|
| Lipoic Acid | 58.6 |
| Placebo | 37.5 |
Inflammatory IL-4 sputum levels after 60 days of treatment. Sputum induction is a semi-invasive technique used to detect and monitor airway inflammation. IL-4 is a Th2 cytokine that promote airway inflammation in asthma. IL-4 drives the production of IgE in B cells. IL-4 was measured by ELISA. (NCT01221350)
Timeframe: 60 days
| Intervention | pg/mL (Mean) |
|---|---|
| Lipoic Acid | 14.53 |
| Placebo | 23.19 |
Inflammatory IL-4 sputum levels after 60 days of treatment. Sputum induction is a semi-invasive technique used to detect and monitor airway inflammation. IL-4 is a Th2 cytokine that promote airway inflammation in asthma. IL-4 drives the production of immunoglobulin E (IgE) in B cells. IL-4 was measured by ELISA. (NCT01221350)
Timeframe: Baseline
| Intervention | pg/mL (Mean) |
|---|---|
| Lipoic Acid | 37.77 |
| Placebo | 39.90 |
Assessment of Quality of life scores with the ACT (Asthma Control Test). The ACT is a way to determine if the asthma symptoms are well controlled. The Asthma Control Test™ (ACT™) is a five question health survey used to measure asthma control in individuals 12 years of age and older. The survey measures the elements of asthma control as defined by the National Heart, Lung, and Blood Institute (NHLBI). ACT is an efficient, reliable, and valid method of measuring asthma control, with or without, lung functioning measures such as spirometry. Each item includes 5 response options corresponding to a 5-point Likert-type rating scale. In scoring the ACT survey, responses for each of the 5 items are summed to yield a score ranging from 5 (poor control of asthma) to 25 (complete control of asthma). (NCT01221350)
Timeframe: Baseline
| Intervention | units on a scale (Mean) |
|---|---|
| Lipoic Acid | 13.65 |
| Placebo | 14.46 |
Assessment of Quality of life scores with the ACT (Asthma Control Test). The ACT is a way to determine if the asthma symptoms are well controlled. The Asthma Control Test™ (ACT™) is a five question health survey used to measure asthma control in individuals 12 years of age and older. The survey measures the elements of asthma control as defined by the National Heart, Lung, and Blood Institute (NHLBI). ACT is an efficient, reliable, and valid method of measuring asthma control, with or without, lung functioning measures such as spirometry. Each item includes 5 response options corresponding to a 5-point Likert-type rating scale. In scoring the ACT survey, responses for each of the 5 items are summed to yield a score ranging from 5 (poor control of asthma) to 25 (complete control of asthma). (NCT01221350)
Timeframe: 60 days
| Intervention | units on a scale (Mean) |
|---|---|
| Lipoic Acid | 19.13 |
| Placebo | 17.71 |
"The Asthma Quality of Life Questionnaire (AQLQ) was developed to measure the functional problems (physical, emotional, social and occupational) that are most troublesome to adults (17-70 years) with asthma.~There are 32 questions in the AQLQ and they are in 4 domains (symptoms, activity limitation, emotional function and environmental stimuli). The activity domain contains 5 'patient-specific' questions. This allows patients to select 5 activities in which they are most limited and these activities will be assessed at each follow-up. Patients are asked to think about how they have been during the previous two weeks and to respond to each of the 32 questions on a 7-point scale (7 = not impaired at all - 1 = severely impaired). The overall AQLQ score is the mean of all 32 responses and the individual domain scores are the means of the items in those domains (http://www.qoltech.co.uk/aqlq.html)." (NCT01221350)
Timeframe: Baseline
| Intervention | units on a scale (Mean) |
|---|---|
| Lipoic Acid | 3.86 |
| Placebo | 3.72 |
"The Asthma Quality of Life Questionnaire (AQLQ) was developed to measure the functional problems (physical, emotional, social and occupational) that are most troublesome to adults (17-70 years) with asthma.~There are 32 questions in the AQLQ and they are in 4 domains (symptoms, activity limitation, emotional function and environmental stimuli). The activity domain contains 5 'patient-specific' questions. This allows patients to select 5 activities in which they are most limited and these activities will be assessed at each follow-up. Patients are asked to think about how they have been during the previous two weeks and to respond to each of the 32 questions on a 7-point scale (7 = not impaired at all - 1 = severely impaired). The overall AQLQ score is the mean of all 32 responses and the individual domain scores are the means of the items in those domains (http://www.qoltech.co.uk/aqlq.html)." (NCT01221350)
Timeframe: 60 days
| Intervention | units on a scale (Mean) |
|---|---|
| Lipoic Acid | 5.57 |
| Placebo | 5.10 |
Measurement of spirometric parameters at baseline: Forced expiratory flow (FEF) is the flow (or speed) of air coming out of the lung during the middle portion of a forced expiration. (NCT01221350)
Timeframe: Baseline
| Intervention | Liters/sec (Mean) |
|---|---|
| Lipoic Acid | 4.89 |
| Placebo | 6.09 |
Measurement of spirometric FEF after 60 days of treatment: Forced expiratory flow (FEF) is the flow (or speed) of air coming out of the lung during the middle portion of a forced expiration. (NCT01221350)
Timeframe: 60 days
| Intervention | Liters/sec (Mean) |
|---|---|
| Lipoic Acid | 5.47 |
| Placebo | 6.10 |
Measurement of spirometric predicted parameters at baseline: Forced expiratory volume in 1 second (FEV1), volume that has been exhaled at the end of the first second of forced expiration. (NCT01221350)
Timeframe: Baseline
| Intervention | Liters (Mean) |
|---|---|
| Lipoic Acid | 2.01 |
| Placebo | 2.37 |
Measurement of spirometric predicted parameters after 60 days of treatment. Forced expiratory volume in 1 second (FEV1), volume that has been exhaled at the end of the first second of forced expiration. (NCT01221350)
Timeframe: 60 days
| Intervention | Liters (Mean) |
|---|---|
| Lipoic Acid | 2.26 |
| Placebo | 2.35 |
Measurement of spirometric predicted parameters at baseline. Forced vital capacity (FVC) is the volume of air that can forcibly be blown out after full inspiration, measured in liters. (NCT01221350)
Timeframe: Baseline
| Intervention | Liters (Mean) |
|---|---|
| Lipoic Acid | 2.74 |
| Placebo | 3.07 |
Measurement of spirometric predicted parameters at the baseline and after 60 days of treatment: Forced vital capacity (FVC) is the volume of air that can forcibly be blown out after full inspiration, measured in liters. (NCT01221350)
Timeframe: 60 days
| Intervention | Liters (Mean) |
|---|---|
| Lipoic Acid | 2.82 |
| Placebo | 3.06 |
18 reviews available for thioctic acid and Aging
| Article | Year |
|---|---|
Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cytokines; Humans; Inflammation Mediators; | 2019 |
Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures.
Topics: Aging; Animals; Antioxidants; Cardiovascular Diseases; Carnitine; Cell Line; Diabetes Mellitus, Type | 2020 |
Management of the aging risk factor for Parkinson's disease.
Topics: Acetylcarnitine; Adenosine Triphosphate; Aging; alpha-Synuclein; Antioxidant Response Elements; Carb | 2014 |
Can α-lipoic acid mitigate progression of aging-related decline caused by oxidative stress?
Topics: Aging; Antioxidants; Dietary Supplements; Humans; Oxidative Stress; Thioctic Acid | 2014 |
Lipoic Acid: its antioxidant and anti-inflammatory role and clinical applications.
Topics: Aging; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Clinical Trials as Topic; Dis | 2015 |
The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stress.
Topics: Aging; Animals; Cardiotonic Agents; Cardiovascular Diseases; Humans; Oxidative Stress; Thioctic Acid | 2015 |
The "rejuvenatory" impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha.
Topics: Aging; Animals; Antioxidants; Hepatocytes; Longevity; Mitochondria, Liver; Oxidative Stress; Oxygen | 2009 |
Alpha-lipoic acid supplementation and diabetes.
Topics: Aging; Animals; Antioxidants; Biological Availability; Diabetes Mellitus; Diabetic Neuropathies; Die | 2008 |
Antioxidants and skin care: the essentials.
Topics: Aging; Antioxidants; Ascorbic Acid; Electron Transport Chain Complex Proteins; Flavonoids; Humans; P | 2010 |
Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid.
Topics: Aging; Endothelium, Vascular; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phospho | 2003 |
Delaying the mitochondrial decay of aging.
Topics: Acetylcarnitine; Aging; Animals; Biotin; Brain; Copper; Heme; Humans; Kinetics; Mitochondria; Pantot | 2004 |
Natural antioxidants and neurodegenerative diseases.
Topics: Acetylcarnitine; Aging; Animals; Antioxidants; Brain; Food; Ginkgo biloba; Humans; Neurodegenerative | 2004 |
Gene expression profiling studies of aging in cardiac and skeletal muscles.
Topics: Aging; Animals; Caloric Restriction; Coenzymes; Gene Expression Profiling; Humans; Mice; Muscle, Ske | 2005 |
The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview.
Topics: Aging; Animals; Cognition Disorders; Humans; Mitochondria; Thioctic Acid | 2008 |
Anti-aging products, Part I. Can supplements rewind our body clocks?
Topics: Advertising; Aging; Antioxidants; Coenzymes; Dietary Supplements; Evidence-Based Medicine; Humans; P | 2001 |
Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue.
Topics: Aging; Animals; Antioxidants; Glutamic Acid; Humans; Long-Term Potentiation; Mitochondria; Nervous S | 2001 |
Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.
Topics: Acetylcarnitine; Aging; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Dietary Supplements; Heart; | 2002 |
[Biologic properties of lipoic acid].
Topics: Acquired Immunodeficiency Syndrome; Aging; Animals; Antioxidants; Cataract; Decarboxylation; Diabeti | 2002 |
8 trials available for thioctic acid and Aging
| Article | Year |
|---|---|
Effects of dietary alpha-lipoic acid supplementation on the seminal parameters and fertility potential in aging broiler breeder roosters.
Topics: Aging; Animal Feed; Animals; Body Weight; Chickens; Dietary Supplements; Female; Fertility; Insemina | 2021 |
α-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction.
Topics: Acute Disease; Aged; Aging; Antioxidants; Ascorbic Acid; Blood Glucose; Cerebral Infarction; Diabete | 2014 |
Nutritional Interventions that Slow the Age-Associated Decline in Renal Function in a Canine Geriatric Model for Elderly Humans.
Topics: Absorptiometry, Photon; Aged; Aging; Animals; Arginine; Biomarkers; Body Weight; Carnitine; Cross-Se | 2016 |
Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics.
Topics: Adult; Age Factors; Aged; Aging; Antioxidants; Ascorbic Acid; Cross-Over Studies; Double-Blind Metho | 2009 |
Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antioxidants; Ascorbic Acid; Brachial Artery; Dru | 2010 |
Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption.
Topics: Administration, Oral; Adult; Aged; Aging; Antioxidants; Ascorbic Acid; Blood Flow Velocity; Blood Pr | 2012 |
Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles.
Topics: Aging; Animals; Antioxidants; Carnitine; Diet; Discrimination Learning; Distance Perception; Dogs; T | 2004 |
Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid.
Topics: Aged; Aging; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique; | 1995 |
85 other studies available for thioctic acid and Aging
| Article | Year |
|---|---|
Lipoic acid and autophagy: new insights into stem cell aging.
Topics: Aging; Animals; Autophagy; Cellular Senescence; Drosophila Proteins; Endosomes; Intestines; Stem Cel | 2020 |
Regulation of aging and oxidative stress pathways in aged pancreatic islets using alpha-lipoic acid.
Topics: Aging; Animals; Cellular Senescence; Insulin-Secreting Cells; MAP Kinase Signaling System; Oxidative | 2018 |
Role of Combined Lipoic Acid and Vitamin D3 on Astrocytes as a Way to Prevent Brain Ageing by Induced Oxidative Stress and Iron Accumulation.
Topics: Aging; Animals; Astrocytes; Cholecalciferol; Humans; Iron; Mice; Oxidative Stress; Thioctic Acid | 2019 |
Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway.
Topics: Aging; AMP-Activated Protein Kinases; Animals; Brain; Cerebral Cortex; Energy Metabolism; Glucose; J | 2013 |
Synthesis of lipoic acid-peptide conjugates and their effect on collagen and melanogenesis.
Topics: Aging; Antioxidants; Collagen; Fibroblasts; Humans; Hyperpigmentation; Matrix Metalloproteinase 1; M | 2013 |
Combination of N-acetylcysteine, α-lipoic acid and α-tocopherol substantially prevents the brain synaptosomal alterations and memory and learning deficits of aged rats.
Topics: Acetylcysteine; Aging; alpha-Tocopherol; Animals; Antioxidants; Brain; Calcium; Dietary Supplements; | 2014 |
Preventive effect of α-lipoic acid on prepulse inhibition deficits in a juvenile two-hit model of schizophrenia.
Topics: Aging; Animals; Disease Models, Animal; Female; Male; Mice, Inbred C57BL; Prefrontal Cortex; Pregnan | 2014 |
Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.
Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Docosahexaenoic Acids; Gene Expression Re | 2014 |
Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age.
Topics: Administration, Oral; Aging; Animals; Circadian Clocks; CLOCK Proteins; Feedback, Physiological; Lip | 2014 |
Multiple mechanisms of age-dependent accumulation of amyloid beta protein in rat brain: Prevention by dietary supplementation with N-acetylcysteine, α-lipoic acid and α-tocopherol.
Topics: Acetylcysteine; Aging; alpha-Tocopherol; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anim | 2016 |
Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.
Topics: Acetylcarnitine; Aging; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Coenzymes | 2016 |
Ginger and alpha lipoic acid ameliorate age-related ultrastructural changes in rat liver.
Topics: Aging; Animals; Antioxidants; Female; Liver; Mitochondria; Oxidative Stress; Rats, Wistar; Thioctic | 2016 |
Biomolecular Modulation of Neurodegenerative Events during Ageing.
Topics: Aging; Animals; Caspase 3; Cell Membrane; Lipid Peroxidation; Male; Microscopy, Fluorescence; Nitric | 2015 |
STRUCTURAL CHANGES IN SUBMANDIBULAR SALIVARY GLAND, CAUSED BY HEAVY METAL SALTS, AND THEIR CORRECTION WITH DIALIPON (EXPERIMENTAL STUDY).
Topics: Aging; Animals; Antioxidants; Fibrosis; Histocytochemistry; Male; Metals, Heavy; Rats; Salts; Subman | 2015 |
The effect of oxidative stress during exercise in the horse.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Competitive Behavior; Diet; Dietary Supplements; Female | 2016 |
Dietary supplementation with N-acetylcysteine, alpha-tocopherol and alpha-lipoic acid prevents age related decline in Na(+),K (+)-ATPase activity and associated peroxidative damage in rat brain synaptosomes.
Topics: Acetylcysteine; Aging; alpha-Tocopherol; Animals; Antioxidants; Brain; Dietary Supplements; Female; | 2008 |
Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes.
Topics: Aging; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome-B(5) Reductase; Enzyme Inh | 2009 |
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.
Topics: Acetylcarnitine; Aging; Animals; Brain; Catalase; Electron Transport Chain Complex Proteins; Glutath | 2009 |
Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.
Topics: Age Factors; Aging; Animals; Antioxidants; Cell Survival; Cells, Cultured; Hepatocytes; Insulin; Mal | 2009 |
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.
Topics: Acetylcarnitine; Aging; Alzheimer Disease; Animals; Antioxidants; Apolipoprotein E4; Brain; Cerebrov | 2009 |
Palladium alpha-lipoic acid complex formulation enhances activities of Krebs cycle dehydrogenases and respiratory complexes I-IV in the heart of aged rats.
Topics: Aging; Animals; Chemistry, Pharmaceutical; Citric Acid Cycle; Heart; Male; Mitochondria, Heart; Myoc | 2009 |
The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients.
Topics: Age Factors; Aging; Animals; Dietary Supplements; DNA, Mitochondrial; Energy Metabolism; Female; Hum | 2010 |
Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles.
Topics: Acetylcarnitine; Aging; Amides; Animals; Antioxidants; Cognition; Dietary Supplements; Dogs; Female; | 2009 |
alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice.
Topics: Aging; Animals; Antioxidants; Blotting, Western; Body Composition; Calorimetry, Indirect; Cell Line; | 2010 |
Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.
Topics: Acetophenones; Aging; Androstadienes; Animals; Antioxidants; Aorta; Apoptosis; Diabetes Mellitus, Ty | 2010 |
Effect of POLY-MVA, a palladium alpha-lipoic acid complex formulation against declined mitochondrial antioxidant status in the myocardium of aged rats.
Topics: Aging; Animals; Antioxidants; Catalase; Glutathione; Glutathione Peroxidase; In Vitro Techniques; Li | 2010 |
Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.
Topics: Aging; Animals; Aorta; Dietary Supplements; Inflammation; Male; Oxidative Stress; Rats; Rats, Inbred | 2010 |
(R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria.
Topics: Administration, Oral; Age Factors; Aging; Animals; Cellular Senescence; Ceramidases; Ceramides; Chro | 2011 |
Immunomodulatory effect of DL-α-lipoic acid in aged rats.
Topics: Aging; Animals; Antioxidants; Free Radicals; Immunologic Factors; Lymphocyte Count; Male; Oxidative | 2011 |
R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.
Topics: Aging; Animals; ARNTL Transcription Factors; Circadian Rhythm; Circadian Rhythm Signaling Peptides a | 2012 |
Antioxidants and endothelial dysfunction in young and elderly people: is flow-mediated dilation useful to assess acute effects?
Topics: Aging; Antioxidants; Ascorbic Acid; Endothelium, Vascular; Female; Humans; Male; Thioctic Acid; Vita | 2012 |
Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats.
Topics: Aging; Animals; Antioxidants; Brain; Catalase; Glucosephosphate Dehydrogenase; Glutathione Peroxidas | 2002 |
Neurochemical changes related to ageing in the rat brain and the effect of DL-alpha-lipoic acid.
Topics: Aging; Animals; Antioxidants; Brain; Dopamine; Male; Neurotransmitter Agents; Norepinephrine; Rats; | 2002 |
Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and lipids in aged rats.
Topics: Age Factors; Aging; Analysis of Variance; Animals; Antioxidants; Lipid Peroxidation; Male; Models, A | 2003 |
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
Topics: Acyltransferases; Administration, Oral; Age Factors; Aging; Aldehydes; Amino Acid Sequence; Animals; | 2003 |
(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis.
Topics: Aging; Animals; Brain; Cysteine; Glutamate-Cysteine Ligase; Glutathione; Kinetics; Male; Myocardium; | 2004 |
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.
Topics: Aging; Animals; Antioxidants; DNA-Binding Proteins; Glutamate-Cysteine Ligase; Glutathione; In Vitro | 2004 |
Antioxidant supplementation normalizes elevated protein kinase C activity in the proximal tubules of old rats.
Topics: Aging; Animals; Antioxidants; Cyclic N-Oxides; Dietary Supplements; Kidney Tubules, Proximal; Male; | 2004 |
Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Carnitine; Diet; Discrimination Learn | 2004 |
L-carnitine and DL-alpha-lipoic acid reverse the age-related deficit in glutathione redox state in skeletal muscle and heart tissues.
Topics: Aging; Animals; Carnitine; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glut | 2004 |
Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age.
Topics: Aging; Clinical Trials as Topic; Coenzymes; DNA, Mitochondrial; Exercise; Fatty Acids, Omega-3; Fatt | 2004 |
Alpha-lipoic acid increases Na+K+ATPase activity and reduces lipofuscin accumulation in discrete brain regions of aged rats.
Topics: Aging; Animals; Antioxidants; Brain; Lipofuscin; Male; Neurons; Rats; Rats, Wistar; Sodium-Potassium | 2004 |
Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders.
Topics: Aging; Animals; Blotting, Western; Brain Chemistry; Chromatography, High Pressure Liquid; Electropho | 2005 |
Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine.
Topics: Aging; Animals; Antioxidants; Carnitine; Male; Mitochondria, Muscle; Oxidative Stress; Rats; Rats, W | 2005 |
Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.
Topics: Aging; Animals; Antioxidants; Brain; Cerebral Cortex; Dietary Supplements; Iron; Male; Rats; Rats, I | 2005 |
Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging.
Topics: Age Factors; Aging; Animals; Carnitine; Citric Acid Cycle; Electron Transport Complex IV; Isocitrate | 2005 |
Plasma protein oxidation in aging rats after alpha-lipoic acid administration.
Topics: Aging; Animals; Blood Proteins; Injections, Intraperitoneal; Male; Oxidation-Reduction; Rats; Rats, | 2005 |
Age-associated deficit of mitochondrial oxidative phosphorylation in skeletal muscle: role of carnitine and lipoic acid.
Topics: Aging; Animals; Carnitine; Cell Respiration; Male; Mitochondria, Muscle; Mitochondrial Swelling; Oxi | 2005 |
Mitochondrial membrane damage during aging process in rat heart: potential efficacy of L-carnitine and DL alpha lipoic acid.
Topics: Aging; Animals; Antioxidants; Cardiolipins; Carnitine; Cytochromes c; Dose-Response Relationship, Dr | 2006 |
Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice.
Topics: Aging; Alzheimer Disease; Animals; Brain; Female; Hippocampus; Memory; Memory Disorders; Mice; Mice, | 2007 |
Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of L-carnitine and DL-alpha-lipoic acid.
Topics: Aging; Animals; Antioxidants; Brain; Carnitine; DNA-Binding Proteins; Lipid Peroxidation; Male; Oxid | 2006 |
Protective efficacy of alpha-lipoic acid on acetylcholinesterase activity in aged rat brain regions.
Topics: Acetylcholinesterase; Aging; Animals; Antioxidants; Brain; Male; Rats; Rats, Wistar; Thioctic Acid | 2006 |
Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Cell Differentiatio | 2006 |
Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process.
Topics: Aging; Animals; Carnitine; Glutathione; Lipid Peroxidation; Male; Mitochondria; Myocardium; Oxidatio | 2006 |
Oxidative stress and DNA single strand breaks in skeletal muscle of aged rats: role of carnitine and lipoicacid.
Topics: Aging; Animals; Antioxidants; Carnitine; DNA Breaks, Single-Stranded; Lipid Peroxidation; Male; Musc | 2006 |
Dietary antioxidants and behavioral enrichment enhance neutrophil phagocytosis in geriatric Beagles.
Topics: Aging; alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Carnitine; CD4-Posi | 2006 |
L-carnitine and alpha-lipoic acid improve age-associated decline in mitochondrial respiratory chain activity of rat heart muscle.
Topics: Aging; Analysis of Variance; Animals; Carnitine; Cell Respiration; Glutamic Acid; Hydroxybutyrates; | 2006 |
Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans.
Topics: Aging; Amyloid beta-Peptides; Animals; Antioxidants; Caenorhabditis elegans; Catechin; Chemotaxis; H | 2006 |
Mitigation of age-dependent oxidative damage to DNA in rat heart by carnitine and lipoic acid.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Age Factors; Aging; Animals; Carnitine; Deoxyguanosine; DNA Breaks, Dou | 2007 |
D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid.
Topics: Adenosine Diphosphate; Aging; Animals; Brain; Electron Transport; Electron Transport Chain Complex P | 2007 |
Mitochondrial ageing and the beneficial role of alpha-lipoic acid.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenosine Triphosphate; Aging; Animals; Citric Acid Cycle; Deoxyguanosi | 2007 |
Effect of alpha-lipoic acid supplementation on trace element levels in serum and in postmitotic tissue in aged rats.
Topics: Aging; Animals; Brain Chemistry; Cations, Divalent; Mitosis; Muscles; Myocardium; Rats; Rats, Spragu | 2007 |
Cytochrome c oxidase rather than cytochrome c is a major determinant of mitochondrial respiratory capacity in skeletal muscle of aged rats: role of carnitine and lipoic acid.
Topics: Administration, Oral; Aging; Animals; Carnitine; Caspases; Cell Nucleus; Cytochromes c; Electron Tra | 2007 |
Carnitine and lipoate ameliorates lipofuscin accumulation and monoamine oxidase activity in aged rat heart.
Topics: Aging; Animals; Antioxidants; Carnitine; Dietary Supplements; In Vitro Techniques; Lipofuscin; Male; | 2007 |
Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats.
Topics: Aging; Animals; Antioxidants; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type | 2008 |
Postmitotic tissue selenium and manganese levels in alpha-lipoic acid-supplemented aged rats.
Topics: Aging; Animals; Antioxidants; Cerebrum; Dietary Supplements; Dose-Response Relationship, Drug; Injec | 2008 |
Age-dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: role of carnitine and lipoic acid.
Topics: Aging; Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Base Sequence; Carnitine; Caspase | 2007 |
Lipoic acid significantly restores, in rats, the age-related decline in vasomotion.
Topics: Aging; Animals; Aorta, Thoracic; Blotting, Western; Ceramides; Endothelium, Vascular; Glutathione; M | 2008 |
Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.
Topics: Acetylcarnitine; Aging; Animals; Dietary Supplements; Hippocampus; Male; Mitochondria; Neurons; Rand | 2009 |
The potent free radical scavenger alpha-lipoic acid improves cognition in rodents.
Topics: Aging; Animals; Avoidance Learning; Cognition; Female; Free Radical Scavengers; Male; Mice; Neuropsy | 1994 |
The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits.
Topics: Aging; Animals; Behavior, Animal; Brain Chemistry; Carbachol; Cognition; Dizocilpine Maleate; Female | 1993 |
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
Topics: Adult; Aged; Aging; Antibodies; Arteries; Arteriosclerosis; Biomarkers; Blood Proteins; Catalase; Ch | 1997 |
Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation.
Topics: Aging; Animals; Ascorbic Acid; Cells, Cultured; Food, Fortified; Kinetics; Liver; Male; Peroxides; R | 1998 |
(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate.
Topics: Aging; Animals; Diet; Dietary Supplements; Lipid Peroxidation; Male; Mitochondria; Oxidation-Reducti | 1999 |
Effect of dl-alpha-lipoic acid on the status of lipid peroxidation and antioxidants in aged rats.
Topics: Aging; Animals; Antioxidants; Catalase; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Mal | 2000 |
Biologic activity of mitochondrial metabolites on aging and age-related hearing loss.
Topics: Acetylcarnitine; Aging; Animals; Auditory Threshold; Biological Transport; Cell Membrane; Cochlear N | 2000 |
Effect of DL-alpha-lipoic acid on tissue nucleic acid contents in aged rats.
Topics: Aging; Animals; DNA; Kidney; Liver; Male; Proteins; Rats; Rats, Wistar; RNA; Spleen; Thioctic Acid | 2000 |
(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo.
Topics: Age Factors; Aging; Animals; Antioxidants; Dose-Response Relationship, Drug; Glutathione; Hepatocyte | 2000 |
Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Cells, Cultured; Dietary Supplements; DNA Damage; Fluor | 2001 |
Effect of DL-alpha-lipoic acid on mitochondrial enzymes in aged rats.
Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Dose-Response Relationship, Drug; Glutathione; Glutathi | 2001 |
Effect of DL-alpha-lipoic acid on glutathione metabolic enzymes in aged rats.
Topics: Aging; Animals; Antioxidants; Dietary Supplements; Glucosephosphate Dehydrogenase; Glutathione; Glut | 2001 |
Dietary modulation of age-related changes in cerebral pro-oxidant status.
Topics: Aging; alpha-Tocopherol; Analysis of Variance; Animals; Antioxidants; Cerebral Cortex; Diet; Glutath | 2002 |
Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid.
Topics: Acetylcarnitine; Aging; Aldehydes; Animals; Antioxidants; Brain; Breast; Carnitine O-Acetyltransfera | 2002 |
Lipoic acid as an antioxidant in mature thoroughbred geldings: a preliminary study.
Topics: Aging; Animal Husbandry; Animals; Antioxidants; Erythrocytes; Glutathione; Glutathione Peroxidase; H | 2002 |
Lipoic acid.
Topics: Adolescent; Adult; Aged; Aging; Aorta; Arteries; Arteriosclerosis; Humans; Middle Aged; Pulmonary Ar | 1974 |