Page last updated: 2024-10-19

thioctic acid and Aging

thioctic acid has been researched along with Aging in 111 studies

Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Co-supplementation of lipoic acid with carnitine has a beneficial effect in reversing the age-related abnormalities seen in aging."7.73Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine. ( Anusuyadevi, M; Panneerselvam, C; Savitha, S; Tamilselvan, J, 2005)
"N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes."7.69Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997)
"D-galactose (D-gal) -induced aging models in Drosophila, houseflies, mice and rats have been widely used; however, the underlying mechanisms are poorly understood."3.74D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. ( Cui, X; Gao, H; Liu, C; Liu, J; Liu, Z; Long, J; Miao, M; Packer, L; Wang, X, 2007)
" In parallel, we have also investigated the levels of carnitine and lipoic acid during aging."3.74Carnitine and lipoate ameliorates lipofuscin accumulation and monoamine oxidase activity in aged rat heart. ( Naveen, B; Panneerselvam, C; Savitha, S, 2007)
"Co-supplementation of lipoic acid with carnitine has a beneficial effect in reversing the age-related abnormalities seen in aging."3.73Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine. ( Anusuyadevi, M; Panneerselvam, C; Savitha, S; Tamilselvan, J, 2005)
"Chronic systemic exposure of mice, rats, and Drosophila to D-galactose causes the acceleration of senescence and has been used as an aging model."3.73Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. ( Cui, X; Hu, Y; Li, X; Liu, J; Long, J; Packer, L; Zhang, Q; Zuo, P, 2006)
"N(epsilon)-(Carboxymethyl)lysine (CML), a major product of oxidative modification of glycated proteins, has been suggested to represent a general marker of oxidative stress and long-term damage to proteins in aging, atherosclerosis, and diabetes."3.69Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging. ( Nerlich, AG; Schleicher, ED; Wagner, E, 1997)
"Reactive hyperemia was reduced with age, but antioxidant administration did not alter the response in either group."2.77Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption. ( Barrett-O'Keefe, Z; Fjeldstad, AS; Harris, RA; Ives, SJ; McDaniel, J; Nishiyama, SK; Richardson, RS; Witman, MA; Wray, DW; Zhao, J, 2012)
"The aging risk factor for Parkinson's disease is described in terms of specific disease markers including mitochondrial and gene dysfunctions relevant to energy metabolism."2.50Management of the aging risk factor for Parkinson's disease. ( Phillipson, OT, 2014)
" Improved endothelial function due to alpha-LA was at least partially attributed to recoupling of eNOS and increased NO bioavailability and represents a pharmacological approach to prevent major complications associated with type 2 diabetes."1.35Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats. ( Boarder, MR; Fernandes, R; Louro, T; Nunes, E; Proença, T; Seiça, RM; Sena, CM, 2008)
"Oxidative stress may play a key role in Alzheimer's disease (AD) neuropathology."1.34Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. ( Bussiere, JR; Hammond, RS; Henson, E; Jones, RE; Montine, TJ; Quinn, JF; Stackman, RW, 2007)

Research

Studies (111)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.90)18.7374
1990's6 (5.41)18.2507
2000's68 (61.26)29.6817
2010's33 (29.73)24.3611
2020's3 (2.70)2.80

Authors

AuthorsStudies
Dos Santos, SM1
Romeiro, CFR1
Rodrigues, CA1
Cerqueira, ARL1
Monteiro, MC1
Zhang, P1
Edgar, BA1
Pagano, G1
Pallardó, FV1
Lyakhovich, A1
Tiano, L1
Fittipaldi, MR1
Toscanesi, M1
Trifuoggi, M1
Behnamifar, A1
Rahimi, S1
Karimi Torshizi, MA1
Sharafi, M1
Grimes, JL1
Nobakht-Haghighi, N1
Rahimifard, M1
Baeeri, M1
Rezvanfar, MA1
Moini Nodeh, S1
Haghi-Aminjan, H1
Hamurtekin, E1
Abdollahi, M1
Molinari, C1
Morsanuto, V1
Ghirlanda, S1
Ruga, S1
Notte, F1
Gaetano, L1
Uberti, F1
Jiang, T1
Yin, F1
Yao, J1
Brinton, RD1
Cadenas, E1
Lu, C1
Kim, BM1
Lee, D1
Lee, MH1
Kim, JH1
Pyo, HB1
Chai, KY1
Phillipson, OT1
Thakurta, IG1
Banerjee, P1
Bagh, MB2
Ghosh, A1
Sahoo, A1
Chattopadhyay, S1
Chakrabarti, S3
Deslauriers, J1
Racine, W1
Sarret, P1
Grignon, S1
Ma, QL1
Zuo, X1
Yang, F1
Ubeda, OJ1
Gant, DJ1
Alaverdyan, M1
Kiosea, NC1
Nazari, S1
Chen, PP1
Nothias, F1
Chan, P1
Teng, E1
Frautschy, SA1
Cole, GM1
Keith, D1
Finlay, L1
Butler, J1
Gómez, L1
Smith, E1
Moreau, R4
Hagen, T1
Patel, MK1
Riley, MA1
Hobbs, S1
Cortez-Cooper, M1
Robinson, VJ1
Zhao, L1
Hu, FX1
Moura, FA1
de Andrade, KQ1
dos Santos, JC1
Goulart, MO1
Skibska, B1
Goraca, A1
Sinha, M1
Bir, A1
Banerjee, A1
Bhowmick, P1
Snigdha, S1
de Rivera, C2
Milgram, NW4
Cotman, CW4
Mahmoud, YI1
Hegazy, HG1
Nebbioso, M1
Scarsella, G1
Librando, A1
Pescosolido, N1
Sikora, V1
Bojko, V1
Tkach, G1
Kyptenko, L1
Lyndin, M1
Williams, CA2
Hall, JA2
Yerramilli, M2
Obare, E1
Panickar, KS1
Bobe, G1
Jewell, DE3
Maiti, AK1
Roy, A1
McCarty, MF1
Barroso-Aranda, J1
Contreras, F1
Gan, L1
von Moltke, LL1
Trepanier, LA1
Harmatz, JS1
Greenblatt, DJ1
Court, MH1
Long, J3
Gao, F1
Tong, L1
Ames, BN7
Liu, J9
Shay, KP2
Hagen, TM15
Singh, U1
Jialal, I1
Shenk, JC2
Fischbach, K2
Xu, K1
Puchowicz, M1
Obrenovich, ME2
Gasimov, E2
Alvarez, LM1
Lamanna, JC1
Aliev, G2
Sudheesh, NP2
Ajith, TA2
Janardhanan, KK2
Krishnan, CV2
Bentov, Y1
Esfandiari, N1
Burstein, E1
Casper, RF1
Christie, LA1
Opii, WO1
Head, E2
Araujo, JA1
Wray, DW3
Nishiyama, SK2
Monnet, A1
Wary, C1
Duteil, SS1
Carlier, PG1
Richardson, RS3
Donato, AJ1
Uberoi, A1
Bailey, DM1
Wang, Y1
Li, X2
Guo, Y1
Chan, L1
Guan, X1
Graf, J1
Bitar, MS1
Ayed, AK1
Abdel-Halim, SM1
Isenovic, ER1
Al-Mulla, F1
Li, L1
Smith, A1
Frei, B4
Monette, JS2
Gómez, LA1
Moreau, RF2
Dunn, KC1
Butler, JA2
Finlay, LA2
Michels, AJ2
Smith, EJ2
Palaniyappan, A1
Alphonse, R1
Petersen, SK1
Harris, RA1
Zhao, J1
McDaniel, J1
Fjeldstad, AS1
Witman, MA1
Ives, SJ1
Barrett-O'Keefe, Z1
Tsikas, D1
Flentje, M1
Niemann, J1
Modun, D1
Arivazhagan, P9
Shila, S2
Kumaran, S3
Panneerselvam, C18
Panneerselvam, SR1
Heath, SH2
Doneanu, CE1
Lindsay, JG1
Smith, AR2
Suh, JH5
Wang, H1
Liu, RM2
Shenvi, SV1
Dixon, BM1
Liu, H1
Jaiswal, AK1
Asghar, M1
Lokhandwala, MF1
Zicker, SC2
Ikeda-Douglas, C1
Murphey, H1
Muggenberg, BA1
Siwak, CT1
Tapp, PD1
Lowry, SR1
Ikeda-Douglas, CJ1
Estrada, J1
Savitha, S6
Anusuya Devi, M1
Rosenfeldt, F1
Miller, F1
Nagley, P1
Hadj, A1
Marasco, S1
Quick, D1
Sheeran, F1
Wowk, M1
Pepe, S1
Bastianetto, S1
Quirion, R1
Poon, HF1
Farr, SA1
Thongboonkerd, V1
Lynn, BC1
Banks, WA1
Morley, JE1
Klein, JB1
Butterfield, DA1
Park, SK1
Prolla, TA1
Tamilselvan, J3
Anusuyadevi, M2
Sivarajan, K4
Haripriya, D1
Kokilavani, V1
Cakatay, U3
Kayali, R3
Panneerselvam, KS2
Quinn, JF1
Bussiere, JR1
Hammond, RS1
Montine, TJ1
Henson, E1
Jones, RE1
Stackman, RW1
Muthuswamy, AD1
Vedagiri, K1
Ganesan, M1
Chinnakannu, P3
Ayusawa, D1
Cui, X2
Zuo, P1
Zhang, Q1
Hu, Y1
Packer, L2
Sethumadhavan, S2
Sundaram, K1
Picton, RA1
Finneran, PS1
Bird, KE1
Skinner, MM1
Zicker, S1
Brown, MK1
Evans, JL1
Luo, Y1
Wang, X1
Gao, H1
Liu, Z1
Liu, C1
Miao, M1
Palaniappan, AR1
Dai, A1
Kiziler, AR2
Aydemir, B2
Naveen, B1
Sena, CM1
Nunes, E1
Louro, T1
Proença, T1
Fernandes, R1
Boarder, MR1
Seiça, RM1
Jayaraman, G1
Visioli, F2
Pacheco, GJ1
Chen, SG1
Ward, WF1
Richardson, AG1
Smith, MA1
Perry, G1
Jacob, S1
Henriksen, EJ1
Schiemann, AL1
Simon, I1
Clancy, DE1
Tritschler, HJ1
Jung, WI1
Augustin, HJ1
Dietze, GJ1
Stoll, S2
Rostock, A1
Bartsch, R1
Korn, E1
Meichelböck, A1
Müller, WE2
Hartmann, H1
Cohen, SA1
Schleicher, ED1
Wagner, E1
Nerlich, AG1
Lykkesfeldt, J2
Vinarsky, V3
Ingersoll, RT1
Wehr, CM2
Bartholomew, JC1
Ames, AB1
Juliet, P1
Seidman, MD1
Khan, MJ1
Bai, U1
Shirwany, N1
Quirk, WS1
Shigeno, ET1
Morrow, JD1
Cox, B1
Rocha, AE1
Ramanathan, K2
Bondy, SC1
Yang, YE1
Walsh, TJ1
Gie, YW1
Lahiri, DK1
Lynch, MA1
Killilea, DW1
Hoffman, RM1
Kronfeld, DS1
Hess, TM1
Saker, KE1
Harris, PA1
Bilska, A1
Włodek, L1
Kirk, JE1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Dose Finding and Tolerability Study of Alpha-lipoic Acid in Patients at Risk for Paclitaxel Induced Peripheral Neuropathy[NCT01313117]Phase 1/Phase 29 participants (Actual)Interventional2012-02-29Completed
Exploratory Study of Lipoic Acid Supplementation on Oxidative Stress, Inflammatory and Functional Markers in Asthmatic Patients: Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Clinical Trial.[NCT01221350]55 participants (Actual)Interventional2010-11-30Completed
The Effect of Concomitant Co Enzyme Q10 Use on Pregnancy Outcome of IVF[NCT01048385]34 participants (Actual)Interventional2009-12-31Terminated (stopped due to A new study had shown that polar body biopsies might negatively effect the implantation potential of the embryo.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cumulative Rate of Adverse Events

(NCT01313117)
Timeframe: 4 months

Interventionparticipants (Number)
Alpha Lipoic Acid9

Identification of the Optimal Dose of ALA Based on Acceptable Adverse Event(AE) Profile

Based on acceptable adverse event (AE) profile and continual reassessment method dose escalation. (NCT01313117)
Timeframe: 4 months

Interventionmg (Number)
Alpha Lipoic Acid500

Proportion of Patients Who Complete the Proposed Regimen of Daily ALA

(NCT01313117)
Timeframe: 4 months

Interventionparticipants (Number)
Alpha Lipoic Acid7

Induced Sputum Carbonylated Proteins at Baseline

Proteins can become modified by a large number of reactions involving reactive oxygen species. Among these, carbonylation is an irreversible and unrepairable oxidative reaction. The main protein modifications originated from oxidative stress comprise direct oxidation of aminoacids with a thiol group, such as cysteine, oxidative glycation, and carbonylation. Oxidative protein carbonylation induce protein degradation in a nonspecific manner. Chemically, oxidative carbonylation preferentially occurs at proline, threonine, lysine, and arginine, presumably through a metal-catalyzed activation of hydrogen peroxide to a reactive intermediate. Carbonylation usually refers to a process that forms reactive ketones or aldehydes that can be reacted by 2,4-dinitrophenylhydrazine (DNPH) to form hydrazones. Direct oxidation of side chains of lysine, arginine, proline, and threonine residues, among other aminoacids, produces DNPH detectable protein products (NCT01221350)
Timeframe: Baseline

Interventionnmol/mg (Mean)
Lipoic Acid7.5
Placebo10.12

Induced Sputum Carbonylated Proteins at Endpoint

Proteins can become modified by a large number of reactions involving reactive oxygen species. Among these, carbonylation is an irreversible and unrepairable oxidative reaction. The main protein modifications originated from oxidative stress comprise direct oxidation of aminoacids with a thiol group, such as cysteine, oxidative glycation, and carbonylation. Oxidative protein carbonylation induce protein degradation in a nonspecific manner. Chemically, oxidative carbonylation preferentially occurs at proline, threonine, lysine, and arginine, presumably through a metal-catalyzed activation of hydrogen peroxide to a reactive intermediate. Carbonylation usually refers to a process that forms reactive ketones or aldehydes that can be reacted by 2,4-dinitrophenylhydrazine (DNPH) to form hydrazones. Direct oxidation of side chains of lysine, arginine, proline, and threonine residues, among other aminoacids, produces DNPH detectable protein products. (NCT01221350)
Timeframe: 60 days

Interventionnmol/mg (Mean)
Lipoic Acid3.24
Placebo4.21

Induced Sputum Eosinophils at Baseline

Eosinophils, a prominent feature of asthma, are found in increased numbers in the circulation and sputum, usually in relation to the severity of asthma. (NCT01221350)
Timeframe: Baseline

InterventionEosinophil percentage in sputum cells (Mean)
Lipoic Acid12.88
Placebo6.10

Induced Sputum Eosinophils at Endpoint

Eosinophils, a prominent feature of asthma, are found in increased numbers in the circulation and sputum, usually in relation to the severity of asthma. (NCT01221350)
Timeframe: 60 days

InterventionEosinophil percentage in sputum cells (Mean)
Lipoic Acid6.39
Placebo5.68

Induced Sputum of Glutathione (GSH)/Glutathione Disulfide (GSSG) Ratio at Baseline

Induced sputum of GSH and GSSG levels at baseline. The ratio GSH/GSSG is considered an index of antioxidant status and reductive -SH groups. GSH and GSSG were measured by a microplate fluorescent assay. (NCT01221350)
Timeframe: Baseline

Interventionratio (Mean)
Lipoic Acid81.42
Placebo35.77

Induced Sputum of Glutathione (GSH)/Glutathione Disulfide (GSSG) Ratio at Endpoint

Change in the induced sputum of antioxidant parameters GSH and GSSG levels after 60 days of treatment. The ratio GSH/GSSG is considered an index of antioxidant status and reductive -SH groups. GSH and GSSG were measured by a microplate fluorescent assay. (NCT01221350)
Timeframe: 60 days

Interventionratio (Mean)
Lipoic Acid58.6
Placebo37.5

Inflammatory IL-4 Sputum Levels at Endpoint

Inflammatory IL-4 sputum levels after 60 days of treatment. Sputum induction is a semi-invasive technique used to detect and monitor airway inflammation. IL-4 is a Th2 cytokine that promote airway inflammation in asthma. IL-4 drives the production of IgE in B cells. IL-4 was measured by ELISA. (NCT01221350)
Timeframe: 60 days

Interventionpg/mL (Mean)
Lipoic Acid14.53
Placebo23.19

Inflammatory Interleukin-4 (IL-4) Sputum Levels at Baseline

Inflammatory IL-4 sputum levels after 60 days of treatment. Sputum induction is a semi-invasive technique used to detect and monitor airway inflammation. IL-4 is a Th2 cytokine that promote airway inflammation in asthma. IL-4 drives the production of immunoglobulin E (IgE) in B cells. IL-4 was measured by ELISA. (NCT01221350)
Timeframe: Baseline

Interventionpg/mL (Mean)
Lipoic Acid37.77
Placebo39.90

Measurement of Quality of Life With the ACT (Asthma Control Test) at Baseline

Assessment of Quality of life scores with the ACT (Asthma Control Test). The ACT is a way to determine if the asthma symptoms are well controlled. The Asthma Control Test™ (ACT™) is a five question health survey used to measure asthma control in individuals 12 years of age and older. The survey measures the elements of asthma control as defined by the National Heart, Lung, and Blood Institute (NHLBI). ACT is an efficient, reliable, and valid method of measuring asthma control, with or without, lung functioning measures such as spirometry. Each item includes 5 response options corresponding to a 5-point Likert-type rating scale. In scoring the ACT survey, responses for each of the 5 items are summed to yield a score ranging from 5 (poor control of asthma) to 25 (complete control of asthma). (NCT01221350)
Timeframe: Baseline

Interventionunits on a scale (Mean)
Lipoic Acid13.65
Placebo14.46

Measurement of Quality of Life With the ACT (Asthma Control Test) at Endpoint

Assessment of Quality of life scores with the ACT (Asthma Control Test). The ACT is a way to determine if the asthma symptoms are well controlled. The Asthma Control Test™ (ACT™) is a five question health survey used to measure asthma control in individuals 12 years of age and older. The survey measures the elements of asthma control as defined by the National Heart, Lung, and Blood Institute (NHLBI). ACT is an efficient, reliable, and valid method of measuring asthma control, with or without, lung functioning measures such as spirometry. Each item includes 5 response options corresponding to a 5-point Likert-type rating scale. In scoring the ACT survey, responses for each of the 5 items are summed to yield a score ranging from 5 (poor control of asthma) to 25 (complete control of asthma). (NCT01221350)
Timeframe: 60 days

Interventionunits on a scale (Mean)
Lipoic Acid19.13
Placebo17.71

Measurement of Quality of Life With the AQLQ (Asthma Quality of Life Questionnaire) at Baseline

"The Asthma Quality of Life Questionnaire (AQLQ) was developed to measure the functional problems (physical, emotional, social and occupational) that are most troublesome to adults (17-70 years) with asthma.~There are 32 questions in the AQLQ and they are in 4 domains (symptoms, activity limitation, emotional function and environmental stimuli). The activity domain contains 5 'patient-specific' questions. This allows patients to select 5 activities in which they are most limited and these activities will be assessed at each follow-up. Patients are asked to think about how they have been during the previous two weeks and to respond to each of the 32 questions on a 7-point scale (7 = not impaired at all - 1 = severely impaired). The overall AQLQ score is the mean of all 32 responses and the individual domain scores are the means of the items in those domains (http://www.qoltech.co.uk/aqlq.html)." (NCT01221350)
Timeframe: Baseline

Interventionunits on a scale (Mean)
Lipoic Acid3.86
Placebo3.72

Measurement of Quality of Life With the AQLQ (Asthma Quality of Life Questionnaire) at Endpoint

"The Asthma Quality of Life Questionnaire (AQLQ) was developed to measure the functional problems (physical, emotional, social and occupational) that are most troublesome to adults (17-70 years) with asthma.~There are 32 questions in the AQLQ and they are in 4 domains (symptoms, activity limitation, emotional function and environmental stimuli). The activity domain contains 5 'patient-specific' questions. This allows patients to select 5 activities in which they are most limited and these activities will be assessed at each follow-up. Patients are asked to think about how they have been during the previous two weeks and to respond to each of the 32 questions on a 7-point scale (7 = not impaired at all - 1 = severely impaired). The overall AQLQ score is the mean of all 32 responses and the individual domain scores are the means of the items in those domains (http://www.qoltech.co.uk/aqlq.html)." (NCT01221350)
Timeframe: 60 days

Interventionunits on a scale (Mean)
Lipoic Acid5.57
Placebo5.10

Spirometric FEF Values at Baseline

Measurement of spirometric parameters at baseline: Forced expiratory flow (FEF) is the flow (or speed) of air coming out of the lung during the middle portion of a forced expiration. (NCT01221350)
Timeframe: Baseline

InterventionLiters/sec (Mean)
Lipoic Acid4.89
Placebo6.09

Spirometric FEF Values at Endpoint

Measurement of spirometric FEF after 60 days of treatment: Forced expiratory flow (FEF) is the flow (or speed) of air coming out of the lung during the middle portion of a forced expiration. (NCT01221350)
Timeframe: 60 days

InterventionLiters/sec (Mean)
Lipoic Acid5.47
Placebo6.10

Spirometric FEV1 Values at Baseline

Measurement of spirometric predicted parameters at baseline: Forced expiratory volume in 1 second (FEV1), volume that has been exhaled at the end of the first second of forced expiration. (NCT01221350)
Timeframe: Baseline

InterventionLiters (Mean)
Lipoic Acid2.01
Placebo2.37

Spirometric FEV1 Values at Endpoint

Measurement of spirometric predicted parameters after 60 days of treatment. Forced expiratory volume in 1 second (FEV1), volume that has been exhaled at the end of the first second of forced expiration. (NCT01221350)
Timeframe: 60 days

InterventionLiters (Mean)
Lipoic Acid2.26
Placebo2.35

Spirometric FVC Values at Baseline

Measurement of spirometric predicted parameters at baseline. Forced vital capacity (FVC) is the volume of air that can forcibly be blown out after full inspiration, measured in liters. (NCT01221350)
Timeframe: Baseline

InterventionLiters (Mean)
Lipoic Acid2.74
Placebo3.07

Spirometric FVC Values at Endpoint

Measurement of spirometric predicted parameters at the baseline and after 60 days of treatment: Forced vital capacity (FVC) is the volume of air that can forcibly be blown out after full inspiration, measured in liters. (NCT01221350)
Timeframe: 60 days

InterventionLiters (Mean)
Lipoic Acid2.82
Placebo3.06

Reviews

18 reviews available for thioctic acid and Aging

ArticleYear
Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cytokines; Humans; Inflammation Mediators;

2019
Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures.
    International journal of molecular sciences, 2020, Sep-25, Volume: 21, Issue:19

    Topics: Aging; Animals; Antioxidants; Cardiovascular Diseases; Carnitine; Cell Line; Diabetes Mellitus, Type

2020
Management of the aging risk factor for Parkinson's disease.
    Neurobiology of aging, 2014, Volume: 35, Issue:4

    Topics: Acetylcarnitine; Adenosine Triphosphate; Aging; alpha-Synuclein; Antioxidant Response Elements; Carb

2014
Can α-lipoic acid mitigate progression of aging-related decline caused by oxidative stress?
    Southern medical journal, 2014, Volume: 107, Issue:12

    Topics: Aging; Antioxidants; Dietary Supplements; Humans; Oxidative Stress; Thioctic Acid

2014
Lipoic Acid: its antioxidant and anti-inflammatory role and clinical applications.
    Current topics in medicinal chemistry, 2015, Volume: 15, Issue:5

    Topics: Aging; Animals; Anti-Inflammatory Agents; Antioxidants; Ascorbic Acid; Clinical Trials as Topic; Dis

2015
The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stress.
    Oxidative medicine and cellular longevity, 2015, Volume: 2015

    Topics: Aging; Animals; Cardiotonic Agents; Cardiovascular Diseases; Humans; Oxidative Stress; Thioctic Acid

2015
The "rejuvenatory" impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha.
    Medical hypotheses, 2009, Volume: 72, Issue:1

    Topics: Aging; Animals; Antioxidants; Hepatocytes; Longevity; Mitochondria, Liver; Oxidative Stress; Oxygen

2009
Alpha-lipoic acid supplementation and diabetes.
    Nutrition reviews, 2008, Volume: 66, Issue:11

    Topics: Aging; Animals; Antioxidants; Biological Availability; Diabetes Mellitus; Diabetic Neuropathies; Die

2008
Antioxidants and skin care: the essentials.
    Plastic and reconstructive surgery, 2010, Volume: 125, Issue:1

    Topics: Aging; Antioxidants; Ascorbic Acid; Electron Transport Chain Complex Proteins; Flavonoids; Humans; P

2010
Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid.
    Biochemical Society transactions, 2003, Volume: 31, Issue:Pt 6

    Topics: Aging; Endothelium, Vascular; Humans; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phospho

2003
Delaying the mitochondrial decay of aging.
    Annals of the New York Academy of Sciences, 2004, Volume: 1019

    Topics: Acetylcarnitine; Aging; Animals; Biotin; Brain; Copper; Heme; Humans; Kinetics; Mitochondria; Pantot

2004
Natural antioxidants and neurodegenerative diseases.
    Frontiers in bioscience : a journal and virtual library, 2004, Sep-01, Volume: 9

    Topics: Acetylcarnitine; Aging; Animals; Antioxidants; Brain; Food; Ginkgo biloba; Humans; Neurodegenerative

2004
Gene expression profiling studies of aging in cardiac and skeletal muscles.
    Cardiovascular research, 2005, May-01, Volume: 66, Issue:2

    Topics: Aging; Animals; Caloric Restriction; Coenzymes; Gene Expression Profiling; Humans; Mice; Muscle, Ske

2005
The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview.
    Neurochemical research, 2008, Volume: 33, Issue:1

    Topics: Aging; Animals; Cognition Disorders; Humans; Mitochondria; Thioctic Acid

2008
Anti-aging products, Part I. Can supplements rewind our body clocks?
    Harvard women's health watch, 2001, Volume: 9, Issue:4

    Topics: Advertising; Aging; Antioxidants; Coenzymes; Dietary Supplements; Evidence-Based Medicine; Humans; P

2001
Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue.
    Nutritional neuroscience, 2001, Volume: 4, Issue:6

    Topics: Aging; Animals; Antioxidants; Glutamic Acid; Humans; Long-Term Potentiation; Mitochondria; Nervous S

2001
Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.
    Annals of the New York Academy of Sciences, 2002, Volume: 959

    Topics: Acetylcarnitine; Aging; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Dietary Supplements; Heart;

2002
[Biologic properties of lipoic acid].
    Postepy higieny i medycyny doswiadczalnej, 2002, Volume: 56, Issue:2

    Topics: Acquired Immunodeficiency Syndrome; Aging; Animals; Antioxidants; Cataract; Decarboxylation; Diabeti

2002

Trials

8 trials available for thioctic acid and Aging

ArticleYear
Effects of dietary alpha-lipoic acid supplementation on the seminal parameters and fertility potential in aging broiler breeder roosters.
    Poultry science, 2021, Volume: 100, Issue:2

    Topics: Aging; Animal Feed; Animals; Body Weight; Chickens; Dietary Supplements; Female; Fertility; Insemina

2021
α-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction.
    European review for medical and pharmacological sciences, 2014, Volume: 18, Issue:23

    Topics: Acute Disease; Aged; Aging; Antioxidants; Ascorbic Acid; Blood Glucose; Cerebral Infarction; Diabete

2014
Nutritional Interventions that Slow the Age-Associated Decline in Renal Function in a Canine Geriatric Model for Elderly Humans.
    The journal of nutrition, health & aging, 2016, Volume: 20, Issue:10

    Topics: Absorptiometry, Photon; Aged; Aging; Animals; Arginine; Biomarkers; Body Weight; Carnitine; Cross-Se

2016
Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5

    Topics: Adult; Age Factors; Aged; Aging; Antioxidants; Ascorbic Acid; Cross-Over Studies; Double-Blind Metho

2009
Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men.
    American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Antioxidants; Ascorbic Acid; Brachial Artery; Dru

2010
Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption.
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 59, Issue:4

    Topics: Administration, Oral; Adult; Aged; Aging; Antioxidants; Ascorbic Acid; Blood Flow Velocity; Blood Pr

2012
Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles.
    Veterinary therapeutics : research in applied veterinary medicine, 2004,Spring, Volume: 5, Issue:1

    Topics: Aging; Animals; Antioxidants; Carnitine; Diet; Discrimination Learning; Distance Perception; Dogs; T

2004
Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid.
    Arzneimittel-Forschung, 1995, Volume: 45, Issue:8

    Topics: Aged; Aging; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Female; Glucose Clamp Technique;

1995

Other Studies

85 other studies available for thioctic acid and Aging

ArticleYear
Lipoic acid and autophagy: new insights into stem cell aging.
    EMBO reports, 2020, 08-05, Volume: 21, Issue:8

    Topics: Aging; Animals; Autophagy; Cellular Senescence; Drosophila Proteins; Endosomes; Intestines; Stem Cel

2020
Regulation of aging and oxidative stress pathways in aged pancreatic islets using alpha-lipoic acid.
    Molecular and cellular biochemistry, 2018, Volume: 449, Issue:1-2

    Topics: Aging; Animals; Cellular Senescence; Insulin-Secreting Cells; MAP Kinase Signaling System; Oxidative

2018
Role of Combined Lipoic Acid and Vitamin D3 on Astrocytes as a Way to Prevent Brain Ageing by Induced Oxidative Stress and Iron Accumulation.
    Oxidative medicine and cellular longevity, 2019, Volume: 2019

    Topics: Aging; Animals; Astrocytes; Cholecalciferol; Humans; Iron; Mice; Oxidative Stress; Thioctic Acid

2019
Lipoic acid restores age-associated impairment of brain energy metabolism through the modulation of Akt/JNK signaling and PGC1α transcriptional pathway.
    Aging cell, 2013, Volume: 12, Issue:6

    Topics: Aging; AMP-Activated Protein Kinases; Animals; Brain; Cerebral Cortex; Energy Metabolism; Glucose; J

2013
Synthesis of lipoic acid-peptide conjugates and their effect on collagen and melanogenesis.
    European journal of medicinal chemistry, 2013, Volume: 69

    Topics: Aging; Antioxidants; Collagen; Fibroblasts; Humans; Hyperpigmentation; Matrix Metalloproteinase 1; M

2013
Combination of N-acetylcysteine, α-lipoic acid and α-tocopherol substantially prevents the brain synaptosomal alterations and memory and learning deficits of aged rats.
    Experimental gerontology, 2014, Volume: 50

    Topics: Acetylcysteine; Aging; alpha-Tocopherol; Animals; Antioxidants; Brain; Calcium; Dietary Supplements;

2014
Preventive effect of α-lipoic acid on prepulse inhibition deficits in a juvenile two-hit model of schizophrenia.
    Neuroscience, 2014, Jul-11, Volume: 272

    Topics: Aging; Animals; Disease Models, Animal; Female; Male; Mice, Inbred C57BL; Prefrontal Cortex; Pregnan

2014
Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014, May-21, Volume: 34, Issue:21

    Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Docosahexaenoic Acids; Gene Expression Re

2014
Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age.
    Biochemical and biophysical research communications, 2014, Jul-18, Volume: 450, Issue:1

    Topics: Administration, Oral; Aging; Animals; Circadian Clocks; CLOCK Proteins; Feedback, Physiological; Lip

2014
Multiple mechanisms of age-dependent accumulation of amyloid beta protein in rat brain: Prevention by dietary supplementation with N-acetylcysteine, α-lipoic acid and α-tocopherol.
    Neurochemistry international, 2016, Volume: 95

    Topics: Acetylcysteine; Aging; alpha-Tocopherol; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Anim

2016
Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine.
    Neurobiology of aging, 2016, Volume: 37

    Topics: Acetylcarnitine; Aging; Animal Nutritional Physiological Phenomena; Animals; Antioxidants; Coenzymes

2016
Ginger and alpha lipoic acid ameliorate age-related ultrastructural changes in rat liver.
    Biotechnic & histochemistry : official publication of the Biological Stain Commission, 2016, Volume: 91, Issue:2

    Topics: Aging; Animals; Antioxidants; Female; Liver; Mitochondria; Oxidative Stress; Rats, Wistar; Thioctic

2016
Biomolecular Modulation of Neurodegenerative Events during Ageing.
    Oxidative medicine and cellular longevity, 2015, Volume: 2015

    Topics: Aging; Animals; Caspase 3; Cell Membrane; Lipid Peroxidation; Male; Microscopy, Fluorescence; Nitric

2015
STRUCTURAL CHANGES IN SUBMANDIBULAR SALIVARY GLAND, CAUSED BY HEAVY METAL SALTS, AND THEIR CORRECTION WITH DIALIPON (EXPERIMENTAL STUDY).
    Georgian medical news, 2015, Issue:249

    Topics: Aging; Animals; Antioxidants; Fibrosis; Histocytochemistry; Male; Metals, Heavy; Rats; Salts; Subman

2015
The effect of oxidative stress during exercise in the horse.
    Journal of animal science, 2016, Volume: 94, Issue:10

    Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Competitive Behavior; Diet; Dietary Supplements; Female

2016
Dietary supplementation with N-acetylcysteine, alpha-tocopherol and alpha-lipoic acid prevents age related decline in Na(+),K (+)-ATPase activity and associated peroxidative damage in rat brain synaptosomes.
    Biogerontology, 2008, Volume: 9, Issue:6

    Topics: Acetylcysteine; Aging; alpha-Tocopherol; Animals; Antioxidants; Brain; Dietary Supplements; Female;

2008
Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 2009, Volume: 37, Issue:1

    Topics: Aging; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Cytochrome-B(5) Reductase; Enzyme Inh

2009
Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.
    Neurochemical research, 2009, Volume: 34, Issue:4

    Topics: Acetylcarnitine; Aging; Animals; Brain; Catalase; Electron Transport Chain Complex Proteins; Glutath

2009
Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.
    Biogerontology, 2009, Volume: 10, Issue:4

    Topics: Age Factors; Aging; Animals; Antioxidants; Cell Survival; Cells, Cultured; Hepatocytes; Insulin; Mal

2009
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.
    Journal of the neurological sciences, 2009, Aug-15, Volume: 283, Issue:1-2

    Topics: Acetylcarnitine; Aging; Alzheimer Disease; Animals; Antioxidants; Apolipoprotein E4; Brain; Cerebrov

2009
Palladium alpha-lipoic acid complex formulation enhances activities of Krebs cycle dehydrogenases and respiratory complexes I-IV in the heart of aged rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2009, Volume: 47, Issue:8

    Topics: Aging; Animals; Chemistry, Pharmaceutical; Citric Acid Cycle; Heart; Male; Mitochondria, Heart; Myoc

2009
The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients.
    Fertility and sterility, 2010, Volume: 93, Issue:1

    Topics: Age Factors; Aging; Animals; Dietary Supplements; DNA, Mitochondrial; Energy Metabolism; Female; Hum

2010
Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles.
    Experimental gerontology, 2009, Volume: 44, Issue:12

    Topics: Acetylcarnitine; Aging; Amides; Animals; Antioxidants; Cognition; Dietary Supplements; Dogs; Female;

2009
alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice.
    Metabolism: clinical and experimental, 2010, Volume: 59, Issue:7

    Topics: Aging; Animals; Antioxidants; Blotting, Western; Body Composition; Calorimetry, Indirect; Cell Line;

2010
Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.
    Life sciences, 2010, Jun-05, Volume: 86, Issue:23-24

    Topics: Acetophenones; Aging; Androstadienes; Animals; Antioxidants; Aorta; Apoptosis; Diabetes Mellitus, Ty

2010
Effect of POLY-MVA, a palladium alpha-lipoic acid complex formulation against declined mitochondrial antioxidant status in the myocardium of aged rats.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:7

    Topics: Aging; Animals; Antioxidants; Catalase; Glutathione; Glutathione Peroxidase; In Vitro Techniques; Li

2010
Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.
    Annals of the New York Academy of Sciences, 2010, Volume: 1203

    Topics: Aging; Animals; Aorta; Dietary Supplements; Inflammation; Male; Oxidative Stress; Rats; Rats, Inbred

2010
(R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria.
    Pharmacological research, 2011, Volume: 63, Issue:1

    Topics: Administration, Oral; Age Factors; Aging; Animals; Cellular Senescence; Ceramidases; Ceramides; Chro

2011
Immunomodulatory effect of DL-α-lipoic acid in aged rats.
    Experimental gerontology, 2011, Volume: 46, Issue:9

    Topics: Aging; Animals; Antioxidants; Free Radicals; Immunologic Factors; Lymphocyte Count; Male; Oxidative

2011
R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2012, Mar-01, Volume: 302, Issue:5

    Topics: Aging; Animals; ARNTL Transcription Factors; Circadian Rhythm; Circadian Rhythm Signaling Peptides a

2012
Antioxidants and endothelial dysfunction in young and elderly people: is flow-mediated dilation useful to assess acute effects?
    Hypertension (Dallas, Tex. : 1979), 2012, Volume: 60, Issue:1

    Topics: Aging; Antioxidants; Ascorbic Acid; Endothelium, Vascular; Female; Humans; Male; Thioctic Acid; Vita

2012
Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats.
    Experimental gerontology, 2002, Volume: 37, Issue:6

    Topics: Aging; Animals; Antioxidants; Brain; Catalase; Glucosephosphate Dehydrogenase; Glutathione Peroxidas

2002
Neurochemical changes related to ageing in the rat brain and the effect of DL-alpha-lipoic acid.
    Experimental gerontology, 2002, Volume: 37, Issue:12

    Topics: Aging; Animals; Antioxidants; Brain; Dopamine; Male; Neurotransmitter Agents; Norepinephrine; Rats;

2002
Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and lipids in aged rats.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2003, Volume: 58, Issue:9

    Topics: Age Factors; Aging; Analysis of Variance; Animals; Antioxidants; Lipid Peroxidation; Male; Models, A

2003
Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.
    Antioxidants & redox signaling, 2003, Volume: 5, Issue:5

    Topics: Acyltransferases; Administration, Oral; Age Factors; Aging; Aldehydes; Amino Acid Sequence; Animals;

2003
(R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis.
    Archives of biochemistry and biophysics, 2004, Mar-01, Volume: 423, Issue:1

    Topics: Aging; Animals; Brain; Cysteine; Glutamate-Cysteine Ligase; Glutathione; Kinetics; Male; Myocardium;

2004
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid.
    Proceedings of the National Academy of Sciences of the United States of America, 2004, Mar-09, Volume: 101, Issue:10

    Topics: Aging; Animals; Antioxidants; DNA-Binding Proteins; Glutamate-Cysteine Ligase; Glutathione; In Vitro

2004
Antioxidant supplementation normalizes elevated protein kinase C activity in the proximal tubules of old rats.
    Experimental biology and medicine (Maywood, N.J.), 2004, Volume: 229, Issue:3

    Topics: Aging; Animals; Antioxidants; Cyclic N-Oxides; Dietary Supplements; Kidney Tubules, Proximal; Male;

2004
Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs.
    Experimental gerontology, 2004, Volume: 39, Issue:5

    Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Carnitine; Diet; Discrimination Learn

2004
L-carnitine and DL-alpha-lipoic acid reverse the age-related deficit in glutathione redox state in skeletal muscle and heart tissues.
    Mechanisms of ageing and development, 2004, Volume: 125, Issue:7

    Topics: Aging; Animals; Carnitine; Glucosephosphate Dehydrogenase; Glutathione; Glutathione Peroxidase; Glut

2004
Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age.
    Annals of the New York Academy of Sciences, 2004, Volume: 1019

    Topics: Aging; Clinical Trials as Topic; Coenzymes; DNA, Mitochondrial; Exercise; Fatty Acids, Omega-3; Fatt

2004
Alpha-lipoic acid increases Na+K+ATPase activity and reduces lipofuscin accumulation in discrete brain regions of aged rats.
    Annals of the New York Academy of Sciences, 2004, Volume: 1019

    Topics: Aging; Animals; Antioxidants; Brain; Lipofuscin; Male; Neurons; Rats; Rats, Wistar; Sodium-Potassium

2004
Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders.
    Neurochemistry international, 2005, Volume: 46, Issue:2

    Topics: Aging; Animals; Blotting, Western; Brain Chemistry; Chromatography, High Pressure Liquid; Electropho

2005
Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine.
    Clinica chimica acta; international journal of clinical chemistry, 2005, Volume: 355, Issue:1-2

    Topics: Aging; Animals; Antioxidants; Carnitine; Male; Mitochondria, Muscle; Oxidative Stress; Rats; Rats, W

2005
Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.
    Redox report : communications in free radical research, 2005, Volume: 10, Issue:1

    Topics: Aging; Animals; Antioxidants; Brain; Cerebral Cortex; Dietary Supplements; Iron; Male; Rats; Rats, I

2005
Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging.
    Clinical nutrition (Edinburgh, Scotland), 2005, Volume: 24, Issue:5

    Topics: Age Factors; Aging; Animals; Carnitine; Citric Acid Cycle; Electron Transport Complex IV; Isocitrate

2005
Plasma protein oxidation in aging rats after alpha-lipoic acid administration.
    Biogerontology, 2005, Volume: 6, Issue:2

    Topics: Aging; Animals; Blood Proteins; Injections, Intraperitoneal; Male; Oxidation-Reduction; Rats; Rats,

2005
Age-associated deficit of mitochondrial oxidative phosphorylation in skeletal muscle: role of carnitine and lipoic acid.
    Molecular and cellular biochemistry, 2005, Volume: 280, Issue:1-2

    Topics: Aging; Animals; Carnitine; Cell Respiration; Male; Mitochondria, Muscle; Mitochondrial Swelling; Oxi

2005
Mitochondrial membrane damage during aging process in rat heart: potential efficacy of L-carnitine and DL alpha lipoic acid.
    Mechanisms of ageing and development, 2006, Volume: 127, Issue:4

    Topics: Aging; Animals; Antioxidants; Cardiolipins; Carnitine; Cytochromes c; Dose-Response Relationship, Dr

2006
Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice.
    Neurobiology of aging, 2007, Volume: 28, Issue:2

    Topics: Aging; Alzheimer Disease; Animals; Brain; Female; Hippocampus; Memory; Memory Disorders; Mice; Mice,

2007
Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of L-carnitine and DL-alpha-lipoic acid.
    Clinica chimica acta; international journal of clinical chemistry, 2006, Volume: 368, Issue:1-2

    Topics: Aging; Animals; Antioxidants; Brain; Carnitine; DNA-Binding Proteins; Lipid Peroxidation; Male; Oxid

2006
Protective efficacy of alpha-lipoic acid on acetylcholinesterase activity in aged rat brain regions.
    Rejuvenation research, 2006,Summer, Volume: 9, Issue:2

    Topics: Acetylcholinesterase; Aging; Animals; Antioxidants; Brain; Male; Rats; Rats, Wistar; Thioctic Acid

2006
Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.
    Journal of neuroscience research, 2006, Aug-15, Volume: 84, Issue:3

    Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Cell Differentiatio

2006
Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process.
    Biogerontology, 2006, Volume: 7, Issue:2

    Topics: Aging; Animals; Carnitine; Glutathione; Lipid Peroxidation; Male; Mitochondria; Myocardium; Oxidatio

2006
Oxidative stress and DNA single strand breaks in skeletal muscle of aged rats: role of carnitine and lipoicacid.
    Biogerontology, 2006, Volume: 7, Issue:2

    Topics: Aging; Animals; Antioxidants; Carnitine; DNA Breaks, Single-Stranded; Lipid Peroxidation; Male; Musc

2006
Dietary antioxidants and behavioral enrichment enhance neutrophil phagocytosis in geriatric Beagles.
    Veterinary immunology and immunopathology, 2006, Sep-15, Volume: 113, Issue:1-2

    Topics: Aging; alpha-Tocopherol; Animals; Antioxidants; Ascorbic Acid; Behavior, Animal; Carnitine; CD4-Posi

2006
L-carnitine and alpha-lipoic acid improve age-associated decline in mitochondrial respiratory chain activity of rat heart muscle.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2006, Volume: 61, Issue:7

    Topics: Aging; Analysis of Variance; Animals; Carnitine; Cell Respiration; Glutamic Acid; Hydroxybutyrates;

2006
Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans.
    Pharmacology, biochemistry, and behavior, 2006, Volume: 85, Issue:3

    Topics: Aging; Amyloid beta-Peptides; Animals; Antioxidants; Caenorhabditis elegans; Catechin; Chemotaxis; H

2006
Mitigation of age-dependent oxidative damage to DNA in rat heart by carnitine and lipoic acid.
    Mechanisms of ageing and development, 2007, Volume: 128, Issue:2

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Age Factors; Aging; Animals; Carnitine; Deoxyguanosine; DNA Breaks, Dou

2007
D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid.
    Biogerontology, 2007, Volume: 8, Issue:3

    Topics: Adenosine Diphosphate; Aging; Animals; Brain; Electron Transport; Electron Transport Chain Complex P

2007
Mitochondrial ageing and the beneficial role of alpha-lipoic acid.
    Neurochemical research, 2007, Volume: 32, Issue:9

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adenosine Triphosphate; Aging; Animals; Citric Acid Cycle; Deoxyguanosi

2007
Effect of alpha-lipoic acid supplementation on trace element levels in serum and in postmitotic tissue in aged rats.
    Medicinal chemistry (Shariqah (United Arab Emirates)), 2007, Volume: 3, Issue:3

    Topics: Aging; Animals; Brain Chemistry; Cations, Divalent; Mitosis; Muscles; Myocardium; Rats; Rats, Spragu

2007
Cytochrome c oxidase rather than cytochrome c is a major determinant of mitochondrial respiratory capacity in skeletal muscle of aged rats: role of carnitine and lipoic acid.
    Rejuvenation research, 2007, Volume: 10, Issue:3

    Topics: Administration, Oral; Aging; Animals; Carnitine; Caspases; Cell Nucleus; Cytochromes c; Electron Tra

2007
Carnitine and lipoate ameliorates lipofuscin accumulation and monoamine oxidase activity in aged rat heart.
    European journal of pharmacology, 2007, Nov-21, Volume: 574, Issue:1

    Topics: Aging; Animals; Antioxidants; Carnitine; Dietary Supplements; In Vitro Techniques; Lipofuscin; Male;

2007
Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats.
    British journal of pharmacology, 2008, Volume: 153, Issue:5

    Topics: Aging; Animals; Antioxidants; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type

2008
Postmitotic tissue selenium and manganese levels in alpha-lipoic acid-supplemented aged rats.
    Chemico-biological interactions, 2008, Feb-15, Volume: 171, Issue:3

    Topics: Aging; Animals; Antioxidants; Cerebrum; Dietary Supplements; Dose-Response Relationship, Drug; Injec

2008
Age-dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: role of carnitine and lipoic acid.
    Free radical biology & medicine, 2007, Dec-15, Volume: 43, Issue:12

    Topics: Aging; Animals; Apoptosis; Apoptotic Protease-Activating Factor 1; Base Sequence; Carnitine; Caspase

2007
Lipoic acid significantly restores, in rats, the age-related decline in vasomotion.
    British journal of pharmacology, 2008, Volume: 153, Issue:8

    Topics: Aging; Animals; Aorta, Thoracic; Blotting, Western; Ceramides; Endothelium, Vascular; Glutathione; M

2008
Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.
    Journal of cellular and molecular medicine, 2009, Volume: 13, Issue:2

    Topics: Acetylcarnitine; Aging; Animals; Dietary Supplements; Hippocampus; Male; Mitochondria; Neurons; Rand

2009
The potent free radical scavenger alpha-lipoic acid improves cognition in rodents.
    Annals of the New York Academy of Sciences, 1994, Jun-30, Volume: 717

    Topics: Aging; Animals; Avoidance Learning; Cognition; Female; Free Radical Scavengers; Male; Mice; Neuropsy

1994
The potent free radical scavenger alpha-lipoic acid improves memory in aged mice: putative relationship to NMDA receptor deficits.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:4

    Topics: Aging; Animals; Behavior, Animal; Brain Chemistry; Carbachol; Cognition; Dizocilpine Maleate; Female

1993
Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.
    The Journal of clinical investigation, 1997, Feb-01, Volume: 99, Issue:3

    Topics: Adult; Aged; Aging; Antibodies; Arteries; Arteriosclerosis; Biomarkers; Blood Proteins; Catalase; Ch

1997
Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1998, Volume: 12, Issue:12

    Topics: Aging; Animals; Ascorbic Acid; Cells, Cultured; Food, Fortified; Kinetics; Liver; Male; Peroxides; R

1998
(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 1999, Volume: 13, Issue:2

    Topics: Aging; Animals; Diet; Dietary Supplements; Lipid Peroxidation; Male; Mitochondria; Oxidation-Reducti

1999
Effect of dl-alpha-lipoic acid on the status of lipid peroxidation and antioxidants in aged rats.
    Pharmacological research, 2000, Volume: 41, Issue:3

    Topics: Aging; Animals; Antioxidants; Catalase; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Mal

2000
Biologic activity of mitochondrial metabolites on aging and age-related hearing loss.
    The American journal of otology, 2000, Volume: 21, Issue:2

    Topics: Acetylcarnitine; Aging; Animals; Auditory Threshold; Biological Transport; Cell Membrane; Cochlear N

2000
Effect of DL-alpha-lipoic acid on tissue nucleic acid contents in aged rats.
    Pharmacological research, 2000, Volume: 42, Issue:3

    Topics: Aging; Animals; DNA; Kidney; Liver; Male; Proteins; Rats; Rats, Wistar; RNA; Spleen; Thioctic Acid

2000
(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo.
    Antioxidants & redox signaling, 2000,Fall, Volume: 2, Issue:3

    Topics: Age Factors; Aging; Animals; Antioxidants; Dose-Response Relationship, Drug; Glutathione; Hepatocyte

2000
Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2001, Volume: 15, Issue:3

    Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Cells, Cultured; Dietary Supplements; DNA Damage; Fluor

2001
Effect of DL-alpha-lipoic acid on mitochondrial enzymes in aged rats.
    Chemico-biological interactions, 2001, Nov-28, Volume: 138, Issue:2

    Topics: Aging; Animals; Antioxidants; Ascorbic Acid; Dose-Response Relationship, Drug; Glutathione; Glutathi

2001
Effect of DL-alpha-lipoic acid on glutathione metabolic enzymes in aged rats.
    Experimental gerontology, 2001, Volume: 37, Issue:1

    Topics: Aging; Animals; Antioxidants; Dietary Supplements; Glucosephosphate Dehydrogenase; Glutathione; Glut

2001
Dietary modulation of age-related changes in cerebral pro-oxidant status.
    Neurochemistry international, 2002, Volume: 40, Issue:2

    Topics: Aging; alpha-Tocopherol; Analysis of Variance; Animals; Antioxidants; Cerebral Cortex; Diet; Glutath

2002
Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid.
    Proceedings of the National Academy of Sciences of the United States of America, 2002, Feb-19, Volume: 99, Issue:4

    Topics: Acetylcarnitine; Aging; Aldehydes; Animals; Antioxidants; Brain; Breast; Carnitine O-Acetyltransfera

2002
Lipoic acid as an antioxidant in mature thoroughbred geldings: a preliminary study.
    The Journal of nutrition, 2002, Volume: 132, Issue:6 Suppl 2

    Topics: Aging; Animal Husbandry; Animals; Antioxidants; Erythrocytes; Glutathione; Glutathione Peroxidase; H

2002
Lipoic acid.
    Monographs on atherosclerosis, 1974, Volume: 4, Issue:0

    Topics: Adolescent; Adult; Aged; Aging; Aorta; Arteries; Arteriosclerosis; Humans; Middle Aged; Pulmonary Ar

1974