thioctic acid has been researched along with Age-Related Memory Disorders in 13 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic systemic exposure of mice, rats, and Drosophila to D-galactose causes the acceleration of senescence and has been used as an aging model." | 3.73 | Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. ( Cui, X; Hu, Y; Li, X; Liu, J; Long, J; Packer, L; Zhang, Q; Zuo, P, 2006) |
| "Scopolamine- induced memory loss is used to study new drug discovery in Alzheimer's disease (AD) pathogenesis." | 1.62 | Alpha lipoic acid ameliorates scopolamine induced memory deficit and neurodegeneration in the cerebello-hippocampal cortex. ( Adewumi, AE; Memudu, AE, 2021) |
| "Total sleep deprivation (TSD) apparatus was used to induce SD (for 24 h)." | 1.56 | The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats. ( Mohammadi-Mahdiabadi-Hasani, MH; Nasehi, M; Nasiri Khalili, MA; Rezaie, M; Vaseghi, S; Zarrindast, MR, 2020) |
| "Oxidative stress may play a key role in Alzheimer's disease (AD) neuropathology." | 1.34 | Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. ( Bussiere, JR; Hammond, RS; Henson, E; Jones, RE; Montine, TJ; Quinn, JF; Stackman, RW, 2007) |
| " Chronic administration of either LA or NAC improved cognition of 12-month-old SAMP8 mice in both the T-maze footshock avoidance paradigm and the lever press appetitive task without inducing non-specific effects on motor activity, motivation to avoid shock, or body weight." | 1.32 | The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. ( Banks, WA; Butterfield, DA; Dogrukol-Ak, D; Drake, J; Eyerman, E; Farr, SA; Morley, JE; Poon, HF, 2003) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (30.77) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 6 (46.15) | 2.80 |
| Authors | Studies |
|---|---|
| Staykov, H | 1 |
| Lazarova, M | 1 |
| Hassanova, Y | 1 |
| Stefanova, M | 1 |
| Tancheva, L | 1 |
| Nikolov, R | 1 |
| Rezaie, M | 1 |
| Nasehi, M | 1 |
| Vaseghi, S | 1 |
| Mohammadi-Mahdiabadi-Hasani, MH | 1 |
| Zarrindast, MR | 1 |
| Nasiri Khalili, MA | 1 |
| Giustina, AD | 1 |
| de Souza Goldim, MP | 1 |
| Danielski, LG | 1 |
| Garbossa, L | 1 |
| Junior, ANO | 1 |
| Cidreira, T | 1 |
| Denicol, T | 1 |
| Bonfante, S | 1 |
| da Rosa, N | 1 |
| Fortunato, JJ | 1 |
| Palandi, J | 1 |
| de Oliveira, BH | 1 |
| Martins, DF | 1 |
| Bobinski, F | 1 |
| Garcez, M | 1 |
| Bellettini-Santos, T | 1 |
| Budni, J | 1 |
| Colpo, G | 1 |
| Scaini, G | 1 |
| Giridharan, VV | 1 |
| Barichello, T | 1 |
| Petronilho, F | 1 |
| Memudu, AE | 1 |
| Adewumi, AE | 1 |
| Wu, D | 1 |
| Liu, H | 1 |
| Liu, Y | 1 |
| Wei, W | 1 |
| Sun, Q | 1 |
| Wen, D | 1 |
| Jia, L | 1 |
| Ghafour-Boroujerdi, E | 1 |
| Rahmani, S | 1 |
| Sanadgol, N | 1 |
| Baeeri, M | 1 |
| Hassani, S | 1 |
| de Sousa, CNS | 1 |
| Meneses, LN | 1 |
| Vasconcelos, GS | 1 |
| da Silva Medeiros, I | 1 |
| Silva, MCC | 1 |
| Mouaffak, F | 1 |
| Kebir, O | 1 |
| da Silva Leite, CMG | 1 |
| Patrocinio, MCA | 1 |
| Macedo, D | 1 |
| Vasconcelos, SMM | 1 |
| Thakurta, IG | 1 |
| Banerjee, P | 1 |
| Bagh, MB | 1 |
| Ghosh, A | 1 |
| Sahoo, A | 1 |
| Chattopadhyay, S | 1 |
| Chakrabarti, S | 1 |
| Villasana, LE | 1 |
| Rosenthal, RA | 1 |
| Doctrow, SR | 1 |
| Pfankuch, T | 1 |
| Zuloaga, DG | 1 |
| Garfinkel, AM | 1 |
| Raber, J | 1 |
| Farr, SA | 1 |
| Poon, HF | 1 |
| Dogrukol-Ak, D | 1 |
| Drake, J | 1 |
| Banks, WA | 1 |
| Eyerman, E | 1 |
| Butterfield, DA | 1 |
| Morley, JE | 1 |
| Quinn, JF | 1 |
| Bussiere, JR | 1 |
| Hammond, RS | 1 |
| Montine, TJ | 1 |
| Henson, E | 1 |
| Jones, RE | 1 |
| Stackman, RW | 1 |
| Cui, X | 2 |
| Zuo, P | 2 |
| Zhang, Q | 2 |
| Li, X | 2 |
| Hu, Y | 2 |
| Long, J | 2 |
| Packer, L | 2 |
| Liu, J | 2 |
13 other studies available for thioctic acid and Age-Related Memory Disorders
| Article | Year |
|---|---|
Neuromodulatory Mechanisms of a Memory Loss-Preventive Effect of Alpha-Lipoic Acid in an Experimental Rat Model of Dementia.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Memory Disorders; Rats; Scopolamine; Thioctic Acid | 2022 |
The protective effect of alpha lipoic acid (ALA) on social interaction memory, but not passive avoidance in sleep-deprived rats.
Topics: Animals; Avoidance Learning; Behavior, Animal; Disease Models, Animal; Locomotion; Male; Memory; Mem | 2020 |
Lipoic Acid and Fish Oil Combination Potentiates Neuroinflammation and Oxidative Stress Regulation and Prevents Cognitive Decline of Rats After Sepsis.
Topics: Animals; Brain; Brain-Derived Neurotrophic Factor; Catalase; Cells, Cultured; Cognitive Dysfunction; | 2020 |
Alpha lipoic acid ameliorates scopolamine induced memory deficit and neurodegeneration in the cerebello-hippocampal cortex.
Topics: Animals; Astrocytes; Body Weight; Brain; Cerebellum; Hippocampus; Male; Memory Disorders; Neurodegen | 2021 |
Protective effect of alpha-lipoic acid on bisphenol A-induced learning and memory impairment in developing mice: nNOS and keap1/Nrf2 pathway.
Topics: Animals; Benzhydryl Compounds; Female; Kelch-Like ECH-Associated Protein 1; Learning; Memory; Memory | 2021 |
Investigation of alpha-lipoic acid effect on memory impairment considering strain-dependent differences in mice.
Topics: Acetylcholinesterase; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Biomarkers; Hippocampu | 2021 |
Neuroprotective evidence of alpha-lipoic acid and desvenlafaxine on memory deficit in a neuroendocrine model of depression.
Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Behavior, Animal; Brain; Corticosterone; Depre | 2018 |
Combination of N-acetylcysteine, α-lipoic acid and α-tocopherol substantially prevents the brain synaptosomal alterations and memory and learning deficits of aged rats.
Topics: Acetylcysteine; Aging; alpha-Tocopherol; Animals; Antioxidants; Brain; Calcium; Dietary Supplements; | 2014 |
Effects of alpha-lipoic acid on associative and spatial memory of sham-irradiated and 56Fe-irradiated C57BL/6J male mice.
Topics: Animals; Antioxidants; Brain; Conditioning, Psychological; Cranial Irradiation; Dentate Gyrus; Iron; | 2013 |
The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.
Topics: Acetylcysteine; Age Factors; Amyloid beta-Peptides; Animals; Antioxidants; Appetitive Behavior; Beha | 2003 |
Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice.
Topics: Aging; Alzheimer Disease; Animals; Brain; Female; Hippocampus; Memory; Memory Disorders; Mice; Mice, | 2007 |
Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.
Topics: Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Dementia; Disease Models, Animal; Galactose; | 2006 |
Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Cell Differentiatio | 2006 |