thioctic acid has been researched along with Adrenoleukodystrophy in 1 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Adrenoleukodystrophy: An X-linked recessive disorder characterized by the accumulation of saturated very long chain fatty acids in the LYSOSOMES of ADRENAL CORTEX and the white matter of CENTRAL NERVOUS SYSTEM. This disease occurs almost exclusively in the males. Clinical features include the childhood onset of ATAXIA; NEUROBEHAVIORAL MANIFESTATIONS; HYPERPIGMENTATION; ADRENAL INSUFFICIENCY; SEIZURES; MUSCLE SPASTICITY; and DEMENTIA. The slowly progressive adult form is called adrenomyeloneuropathy. The defective gene ABCD1 is located at Xq28, and encodes the adrenoleukodystrophy protein (ATP-BINDING CASSETTE TRANSPORTERS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "X-linked adrenoleukodystrophy is a neurodegenerative condition caused by loss of function of the peroxisomal ABCD1 transporter, in which oxidative stress plays a pivotal role." | 1.38 | Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy. ( Andreu, AL; Bianchi, P; Ferrer, I; Fourcade, S; Galino, J; López-Erauskin, J; Muñoz-Pinedo, C; Pujol, A, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| López-Erauskin, J | 1 |
| Galino, J | 1 |
| Bianchi, P | 1 |
| Fourcade, S | 1 |
| Andreu, AL | 1 |
| Ferrer, I | 1 |
| Muñoz-Pinedo, C | 1 |
| Pujol, A | 1 |
1 other study available for thioctic acid and Adrenoleukodystrophy
| Article | Year |
|---|---|
Oxidative stress modulates mitochondrial failure and cyclophilin D function in X-linked adrenoleukodystrophy.
Topics: Acetylcysteine; Adenosine Triphosphate; Adrenoleukodystrophy; Age Factors; Analysis of Variance; Ani | 2012 |