thioctic acid has been researched along with Acute Liver Injury, Drug-Induced in 47 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Amiodarone (AMD) is a widely used antiarrhythmic drug prescribed to treat cardiac tachyarrhythmias; however, AMD has been reported to provoke pulmonary fibrosis (PF) and hepatotoxicity." | 8.02 | The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats. ( Ibrahim Fouad, G; R Mousa, M, 2021) |
| "Liver cirrhosis is the final consequence of a progressive fibrotic process characterized by excessive collagen deposition and destruction of the normal liver architecture." | 5.40 | Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. ( Ali, SO; Darwish, HA; Ismail, NA, 2014) |
| "Amiodarone (AMD) is a widely used antiarrhythmic drug prescribed to treat cardiac tachyarrhythmias; however, AMD has been reported to provoke pulmonary fibrosis (PF) and hepatotoxicity." | 4.02 | The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats. ( Ibrahim Fouad, G; R Mousa, M, 2021) |
| " Amatoxin, a peptide contained in several mushroom species, accounts for the majority of severe mushroom poisonings by binding to RNA polymerase II irreversibly, leading to severe hepatonecrosis." | 3.74 | Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model. ( Betten, DP; Clark, RF; Favata, M; Hernandez, M; Richardson, WH; Riffenburgh, RH; Tanen, DA; Tong, TC, 2007) |
| "Bisphenol A (BPA) is a commonly used material in daily life, and it is argued to cause oxidative stress in liver and ovarian tissue." | 1.43 | Influence of α-tocopherol and α-lipoic acid on bisphenol-A-induced oxidative damage in liver and ovarian tissue of rats. ( Avci, B; Bahadir, A; Bilgici, B; Tuncel, OK, 2016) |
| " Pharmacokinetic study revealed a 1." | 1.43 | Alpha-lipoic acid-stearylamine conjugate-based solid lipid nanoparticles for tamoxifen delivery: formulation, optimization, in-vivo pharmacokinetic and hepatotoxicity study. ( Chand, M; Dhaundiyal, A; Jena, SK; Samal, SK; Sangamwar, AT; Sonvane, B, 2016) |
| "Acetaminophen (paracetamol) is a well-tolerated analgesic and antipyretic drug when used at therapeutic doses." | 1.42 | Alpha-lipoic acid treatment of acetaminophen-induced rat liver damage. ( Mahmoud, AA; Mahmoud, YI; Nassar, G, 2015) |
| "Liver cirrhosis is the final consequence of a progressive fibrotic process characterized by excessive collagen deposition and destruction of the normal liver architecture." | 1.40 | Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats. ( Ali, SO; Darwish, HA; Ismail, NA, 2014) |
| "Thioctic acid treatment was discontinued 2 days after admission." | 1.37 | Thioctic acid-induced acute cholestatic hepatitis. ( Castiglioni, T; Ridruejo, E; Silva, MO, 2011) |
| "Twenty-seven consecutive mushroom poisoning cases were followed up over a period of 14 days." | 1.28 | Poisoning due to amatoxin-containing Lepiota species. ( Erken, E; Erturk, F; Gurcay, A; Kocak, R; Paydas, S; Zaksu, HS, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (23.40) | 18.7374 |
| 1990's | 3 (6.38) | 18.2507 |
| 2000's | 6 (12.77) | 29.6817 |
| 2010's | 21 (44.68) | 24.3611 |
| 2020's | 6 (12.77) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Kuraishy, HM | 1 |
| Abd Hasan, RR | 1 |
| Al-Gareeb, AIA | 1 |
| Aggad, SS | 1 |
| Aljohani, ASM | 1 |
| El-Ashmawy, IM | 1 |
| Elekhnawy, E | 1 |
| Mostafa, SA | 1 |
| Negm, WA | 1 |
| Batiha, GE | 1 |
| Yan, Z | 1 |
| Wan, J | 2 |
| Liu, J | 1 |
| Yao, B | 1 |
| Lu, Y | 1 |
| Guo, Z | 1 |
| Li, Y | 1 |
| Pınar, N | 1 |
| Çakırca, G | 1 |
| Hakverdi, S | 1 |
| Kaplan, M | 1 |
| Gu, L | 1 |
| Li, S | 1 |
| Bai, J | 1 |
| Zhang, Q | 1 |
| Han, Z | 1 |
| Ibrahim Fouad, G | 1 |
| R Mousa, M | 1 |
| Yaqub, F | 1 |
| Latief, N | 1 |
| Butt, H | 1 |
| Naseer, N | 1 |
| Riazuddin, S | 1 |
| Sadek, KM | 1 |
| Saleh, EA | 1 |
| Nasr, SM | 1 |
| Topsakal, S | 1 |
| Ozmen, O | 1 |
| Ozgocmen, M | 1 |
| Abdulrazzaq, AM | 1 |
| Badr, M | 1 |
| Gammoh, O | 1 |
| Abu Khalil, AA | 1 |
| Ghanim, BY | 1 |
| Alhussainy, TM | 1 |
| Qinna, NA | 1 |
| Amin, KA | 1 |
| Hashem, KS | 1 |
| Al-muzafar, HM | 1 |
| Taha, EM | 1 |
| Elshazly, SM | 1 |
| El-Moselhy, MA | 1 |
| Barakat, W | 1 |
| Ali, SO | 1 |
| Darwish, HA | 1 |
| Ismail, NA | 1 |
| Tanaka, Y | 1 |
| Kaibori, M | 1 |
| Miki, H | 1 |
| Nakatake, R | 1 |
| Tokuhara, K | 1 |
| Nishizawa, M | 1 |
| Okumura, T | 1 |
| Kwon, AH | 1 |
| Aly, HA | 1 |
| Mansour, AM | 1 |
| Hassan, MH | 1 |
| Abd-Ellah, MF | 1 |
| Avci, B | 1 |
| Bahadir, A | 1 |
| Tuncel, OK | 1 |
| Bilgici, B | 1 |
| Armagan, I | 1 |
| Bayram, D | 1 |
| Candan, IA | 1 |
| Yigit, A | 1 |
| Celik, E | 1 |
| Armagan, HH | 1 |
| Uğuz, AC | 1 |
| Çakır, T | 1 |
| Baştürk, A | 1 |
| Polat, C | 1 |
| Aslaner, A | 1 |
| Durgut, H | 1 |
| Şehirli, AÖ | 1 |
| Gül, M | 1 |
| Öğünç, AV | 1 |
| Gül, S | 1 |
| Sabuncuoglu, MZ | 1 |
| Oruç, MT | 1 |
| Puri, BK | 1 |
| Hakkarainen-Smith, JS | 1 |
| Derham, A | 1 |
| Monro, JA | 1 |
| Mahmoud, YI | 1 |
| Mahmoud, AA | 1 |
| Nassar, G | 1 |
| Wang, J | 2 |
| Yang, G | 1 |
| Dubrovsky, AM | 1 |
| Choi, J | 1 |
| Leung, PS | 1 |
| Fei, M | 1 |
| Xie, Q | 1 |
| Zou, Y | 1 |
| He, R | 1 |
| Zhang, Y | 1 |
| Bo, L | 1 |
| Li, J | 1 |
| Deng, X | 1 |
| Dhaundiyal, A | 1 |
| Jena, SK | 1 |
| Samal, SK | 1 |
| Sonvane, B | 1 |
| Chand, M | 1 |
| Sangamwar, AT | 1 |
| Khalaf, AA | 1 |
| Zaki, AR | 1 |
| Galal, MK | 1 |
| Ogaly, HA | 1 |
| Ibrahim, MA | 1 |
| Hassan, A | 1 |
| Shanmugarajan, TS | 1 |
| Sivaraman, D | 1 |
| Somasundaram, I | 1 |
| Arunsundar, M | 1 |
| Krishnakumar, E | 1 |
| Balaji, R | 1 |
| Ravichandiran, V | 1 |
| Saad, EI | 1 |
| El-Gowilly, SM | 1 |
| Sherhaa, MO | 1 |
| Bistawroos, AE | 1 |
| Ridruejo, E | 1 |
| Castiglioni, T | 1 |
| Silva, MO | 1 |
| Tian, YF | 1 |
| Hsieh, CH | 1 |
| Hsieh, YJ | 1 |
| Chen, YT | 1 |
| Peng, YJ | 1 |
| Hsieh, PS | 1 |
| Lu, H | 1 |
| Jiang, R | 1 |
| Xie, J | 1 |
| Peng, X | 1 |
| Zhang, L | 1 |
| Suntres, ZE | 1 |
| Selvakumar, E | 1 |
| Prahalathan, C | 1 |
| Mythili, Y | 1 |
| Varalakshmi, P | 1 |
| Tong, TC | 1 |
| Hernandez, M | 1 |
| Richardson, WH | 1 |
| Betten, DP | 1 |
| Favata, M | 1 |
| Riffenburgh, RH | 1 |
| Clark, RF | 1 |
| Tanen, DA | 1 |
| Abdel-Zaher, AO | 1 |
| Abdel-Hady, RH | 1 |
| Mahmoud, MM | 1 |
| Farrag, MM | 1 |
| Anandakumar, PP | 1 |
| Malarkodi, SP | 1 |
| Sivaprasad, TR | 1 |
| Saravanan, GD | 1 |
| Kuz'menko, SA | 1 |
| Lokaĭ, AI | 1 |
| Smorshchok, SA | 1 |
| Volkov, KS | 1 |
| Christen, U | 2 |
| Quinn, J | 1 |
| Yeaman, SJ | 1 |
| Kenna, JG | 1 |
| Clarke, JB | 1 |
| Gandolfi, AJ | 1 |
| Gut, J | 2 |
| Frey, N | 1 |
| Koch, V | 1 |
| Stoffler, D | 1 |
| Frimmer, M | 1 |
| Petzinger, E | 1 |
| Homann, J | 1 |
| Möller, E | 1 |
| Schmitt, R | 1 |
| Paydas, S | 1 |
| Kocak, R | 1 |
| Erturk, F | 1 |
| Erken, E | 1 |
| Zaksu, HS | 1 |
| Gurcay, A | 1 |
| Parish, RC | 1 |
| Doering, PL | 1 |
| Hecht, Y | 1 |
| Barbier, P | 1 |
| Caroli, J | 1 |
| Sakamoto, K | 1 |
| Matsushima, Y | 1 |
| Kasahara, T | 1 |
| Ilinich, VK | 1 |
| Plastun, FF | 1 |
| Zulik, R | 1 |
| Bako, F | 1 |
| Kisbán, A | 1 |
| Strubelt, O | 1 |
| Siegers, CP | 1 |
| Schütt, A | 1 |
| Moser, K | 1 |
| Lujf, A | 1 |
| Kobayashi, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Alpha Lipoic Acid on Non-alcoholic Fatty Liver Diseases: A Randomized Placebo-controlled Clinical Trial[NCT04475276] | Phase 4 | 120 participants (Anticipated) | Interventional | 2021-02-23 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for thioctic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Xenobiotics and loss of tolerance in primary biliary cholangitis.
Topics: Acetaminophen; Animals; Autoantibodies; Autoantigens; Chemical and Drug Induced Liver Injury; Cholan | 2016 |
Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens.
Topics: Autoantigens; Chemical and Drug Induced Liver Injury; Cross Reactions; Halothane; Humans; Liver Cirr | 1995 |
Treatment of Amanita mushroom poisoning: a review.
Topics: Amanitins; Animals; Blood Glucose; Charcoal; Chemical and Drug Induced Liver Injury; Diuresis; Gluco | 1986 |
[Treatment of acute hepatic insufficiency (a survey of the literature)].
Topics: Acute Disease; Adenosine Triphosphate; Arginine; Chemical and Drug Induced Liver Injury; Exchange Tr | 1972 |
1 trial available for thioctic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
[A contribution to the treatment of chronic liver diseases (author's transl)].
Topics: Administration, Oral; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Chronic Disease; Cl | 1976 |
42 other studies available for thioctic acid and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Elucidation of the role of α-lipoic acid and vitamin C in methotrexate-induced hepatoxicity in mice.
Topics: Animals; Antioxidants; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Glutathione; Liver; Ma | 2023 |
α-lipoic acid ameliorates hepatotoxicity induced by chronic ammonia toxicity in crucian carp (Carassius auratus gibelio) by alleviating oxidative stress, inflammation and inhibiting ERS pathway.
Topics: Ammonia; Animals; Antioxidants; Carps; Chemical and Drug Induced Liver Injury; Goldfish; Humans; Inf | 2023 |
Protective effect of alpha lipoic acid on cisplatin induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Female; Free Radical Scavengers; Glut | 2020 |
α-Lipoic acid protects against microcystin-LR induced hepatotoxicity through regeneration of glutathione via activation of Nrf2.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Glutathione; Glutathione Reductase; H | 2020 |
The protective potential of alpha lipoic acid on amiodarone-induced pulmonary fibrosis and hepatic injury in rats.
Topics: Alanine Transaminase; Amiodarone; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cyt | 2021 |
Alpha lipoic acid priming enhances the hepatoprotective effect of adipose derived stem cells in CCl4 induced hepatic injury in-vitro.
Topics: Adipose Tissue; Animals; Carbon Tetrachloride; Cells, Cultured; Chemical and Drug Induced Liver Inju | 2021 |
Molecular hepatoprotective effects of lipoic acid against carbon tetrachloride-induced liver fibrosis in rats: Hepatoprotection at molecular level.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Collagen; Cytoprotection; Inf | 2018 |
Effects of alpha-lipoic acid on high fructose induced hepatic pathology.
Topics: Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Female; Hepatocytes; High | 2019 |
Hepatoprotective Actions of Ascorbic Acid, Alpha Lipoic Acid and Silymarin or Their Combination Against Acetaminophen-Induced Hepatotoxicity in Rats.
Topics: Acetaminophen; Animals; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Disease Models, Anima | 2019 |
Oxidative hepatotoxicity effects of monocrotaline and its amelioration by lipoic acid, S-adenosyl methionine and vitamin E.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Monocrotaline; Oxidants; Oxidative St | 2014 |
Insights in the mechanism underlying the protective effect of α-lipoic acid against acetaminophen-hepatotoxicity.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 2014 |
Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Curcumin; Gene Expression | 2014 |
Alpha-lipoic acid exerts a liver-protective effect in acute liver injury rats.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Drug Evaluation, Preclinical; Galacto | 2015 |
Lipoic acid attenuates Aroclor 1260-induced hepatotoxicity in adult rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidants; Aroclors; Aspartate Aminotransfer | 2016 |
Influence of α-tocopherol and α-lipoic acid on bisphenol-A-induced oxidative damage in liver and ovarian tissue of rats.
Topics: Administration, Oral; Advanced Oxidation Protein Products; alpha-Tocopherol; Animals; Antioxidants; | 2016 |
Effects of pentoxifylline and alpha lipoic acid on methotrexate-induced damage in liver and kidney of rats.
Topics: Animals; Antioxidants; Biomarkers; Chemical and Drug Induced Liver Injury; Disease Models, Animal; G | 2015 |
Does alfa lipoic acid prevent liver from methotrexate induced oxidative injury in rats?
Topics: Animals; Anti-Inflammatory Agents; Antimetabolites, Antineoplastic; Antioxidants; Chemical and Drug | 2015 |
Co-administration of α-lipoic acid and glutathione is associated with no significant changes in serum bilirubin, alkaline phosphatase or γ-glutamyltranspeptidase levels during the treatment of neuroborreliosis with intravenous ceftriaxone.
Topics: Administration, Intravenous; Adult; Alkaline Phosphatase; Anti-Bacterial Agents; Bilirubin; Ceftriax | 2015 |
Alpha-lipoic acid treatment of acetaminophen-induced rat liver damage.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Antioxidants; Chemical and Drug Induced Liver Inju | 2015 |
Alpha-lipoic acid protects mice against concanavalin A-induced hepatitis by modulating cytokine secretion and reducing reactive oxygen species generation.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 2016 |
Alpha-lipoic acid-stearylamine conjugate-based solid lipid nanoparticles for tamoxifen delivery: formulation, optimization, in-vivo pharmacokinetic and hepatotoxicity study.
Topics: Administration, Oral; Amines; Animals; Biological Availability; Chemical and Drug Induced Liver Inju | 2016 |
The potential protective effect of α-lipoic acid against nanocopper particle-induced hepatotoxicity in male rats.
Topics: Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Copper; Lipid Peroxidation | 2017 |
Influence of alpha lipoic acid on antioxidant status in D-galactosamine-induced hepatic injury.
Topics: Analysis of Variance; Animals; Antioxidants; Biomarkers; Catalase; Chemical and Drug Induced Liver I | 2008 |
Role of oxidative stress and nitric oxide in the protective effects of alpha-lipoic acid and aminoguanidine against isoniazid-rifampicin-induced hepatotoxicity in rats.
Topics: Animals; Antioxidants; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Glutathione; G | 2010 |
Thioctic acid-induced acute cholestatic hepatitis.
Topics: Antioxidants; Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Diabetes Mellitus, | 2011 |
α-Lipoic acid prevents mild portal endotoxaemia-induced hepatic inflammation and β cell dysfunction.
Topics: Analysis of Variance; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Endotoxemia; In | 2012 |
Sodium butyrate potentiates carbon tetrachloride-induced acute liver injury in mice.
Topics: Acetylcysteine; Animals; Butyrates; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical a | 2012 |
Prophylaxis against lipopolysaccharide-induced liver injuries by lipoic acid in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 2003 |
Mitigation of oxidative stress in cyclophosphamide-challenged hepatic tissue by DL-alpha-lipoic acid.
Topics: Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Lipid Peroxidation; | 2005 |
Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model.
Topics: Acetylcysteine; Alanine Transaminase; Amanitins; Animals; Antidotes; Aspartate Aminotransferases; Ch | 2007 |
The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage.
Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Alkaline Phosphatase; Animals; Antioxidan | 2008 |
Antioxidant DL-alpha lipoic acid as an attenuator of adriamycin induced hepatotoxicity in rat model.
Topics: Animals; Antibiotics, Antineoplastic; Antioxidants; Chemical and Drug Induced Liver Injury; Doxorubi | 2007 |
[Effect of lipoic acid, cocarboxylase and prednisolone on hepatocyte ultrastructure in toxic hepatitis].
Topics: Animals; Chemical and Drug Induced Liver Injury; Liver; Male; Mushroom Poisoning; Prednisolone; Rats | 1982 |
Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid.
Topics: Acetyltransferases; Amino Acid Sequence; Autoantigens; Autoimmune Diseases; Binding, Competitive; Ch | 1994 |
[Phalloidin antagonists 4th communication: Thioctic acid, SH-compounds, rifampicin, choleretics, dexamethasone, estradiol, unspecific inhibitors, and ineffective compounds (author's transl)].
Topics: Animals; Chelating Agents; Chemical and Drug Induced Liver Injury; Chloroform; Cholagogues and Chole | 1975 |
Poisoning due to amatoxin-containing Lepiota species.
Topics: Adolescent; Adult; Amanitins; Chemical and Drug Induced Liver Injury; Child; Coma; Female; Humans; M | 1990 |
[Coenzyme treatment of severe jaundice due to hepatitis (Thölen's method)].
Topics: Adolescent; Adult; Chemical and Drug Induced Liver Injury; Coenzyme A; Coenzymes; Female; Hepatic En | 1967 |
[Effects of methionine and thioctic acid on ethionine-damaged liver].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1972 |
[The treatment of death-cap poisoning (author's transl)].
Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Antitoxins; Chemical and Drug Induced Liver Injury; Ci | 1973 |
The curative effects of cysteamine, cysteine, and dithiocarb in experimental paracetamol poisoning.
Topics: Acetaminophen; Alcohols; Animals; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Cysteami | 1974 |
[Metabolic changes in liver diseases and experimental liver damage caused by carbon tetrachloride].
Topics: Animals; Carbon Tetrachloride Poisoning; Carboxy-Lyases; Chemical and Drug Induced Liver Injury; Cit | 1967 |
[Pharmacological studies on liver-acting agents 2. Effects of so-called liver drugs on the ethionine-damaged liver].
Topics: Animals; Bile Acids and Salts; Blood Proteins; Chemical and Drug Induced Liver Injury; Ethionine; Gl | 1966 |