thioctic acid has been researched along with Acute Disease in 21 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to investigate the effect of alpha-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats." | 7.73 | Alpha-lipoic acid protects against cholecystokinin-induced acute pancreatitis in rats. ( Choi, OS; Park, CS; Park, SJ; Seo, SW, 2005) |
| "Inflammation was induced by injection of 0." | 5.36 | Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA. ( El-Desoky, K; El-Ghareib, MA; El-Masry, SA; El-Shitany, NA, 2010) |
| "The effect of original domestic derivatives of 3-oxypiridine and succinic acid (emoxipine, reamberin and mexidol) on the resistance to acute brain ischemia was studied in an experimental mouse models." | 3.80 | [The effect of 3-oxypyridine and succinic acid derivatives on the resistance to acute cerebral ischemia]. ( Faĭzullin, RM; Kalugina, AV; Malkin, MP; Miroshnichenko, II; Priakhina, KE; Rassokhina, LM; Volchegorskiĭ, IA, 2014) |
| " The aim of this study was to investigate the effect of alpha-lipoic acid on cholecystokinin (CCK)-octapeptide induced acute pancreatitis in rats." | 3.73 | Alpha-lipoic acid protects against cholecystokinin-induced acute pancreatitis in rats. ( Choi, OS; Park, CS; Park, SJ; Seo, SW, 2005) |
| "Sepsis is a complication of an infection which imbalance the normal regulation of several organ systems, including the central nervous system (CNS)." | 1.46 | Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis. ( Barichello, T; Bellettini-Santos, T; Budni, J; da Rosa, N; Dal-Pizzol, F; Danielski, LG; Della Giustina, A; Fileti, ME; Florentino, D; Fortunato, JJ; Garbossa, L; Goldim, MP; Martins Laurentino, AO; Mathias, K; Mina, F; Oliveira Junior, AN; Petronilho, F; Zarbato, GF, 2017) |
| "Polyneuropathies were specified as toxic/metabolic with the prevalence of a demyelinating component within the main disease in 18 (67%) patients." | 1.38 | [Demyelinating polyneuropathies in patients with diabetes mellitus and chronic alcoholic intoxication]. ( Kovrazhkina, EA, 2012) |
| "Inflammation was induced by injection of 0." | 1.36 | Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA. ( El-Desoky, K; El-Ghareib, MA; El-Masry, SA; El-Shitany, NA, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (28.57) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Ali, SHK | 1 |
| Raja, KWA | 1 |
| Irfan, N | 1 |
| Habeeb, M | 1 |
| Ismail, Y | 1 |
| Lee, Y | 1 |
| Lim, JW | 1 |
| Kim, H | 1 |
| Pagano, G | 1 |
| Manfredi, C | 1 |
| Pallardó, FV | 1 |
| Lyakhovich, A | 1 |
| Tiano, L | 1 |
| Trifuoggi, M | 1 |
| Della Giustina, A | 1 |
| Goldim, MP | 1 |
| Danielski, LG | 1 |
| Florentino, D | 1 |
| Mathias, K | 1 |
| Garbossa, L | 1 |
| Oliveira Junior, AN | 1 |
| Fileti, ME | 1 |
| Zarbato, GF | 1 |
| da Rosa, N | 1 |
| Martins Laurentino, AO | 1 |
| Fortunato, JJ | 1 |
| Mina, F | 1 |
| Bellettini-Santos, T | 1 |
| Budni, J | 1 |
| Barichello, T | 1 |
| Dal-Pizzol, F | 1 |
| Petronilho, F | 1 |
| Zhao, L | 1 |
| Hu, FX | 1 |
| Volchegorskiĭ, IA | 1 |
| Miroshnichenko, II | 1 |
| Rassokhina, LM | 1 |
| Faĭzullin, RM | 1 |
| Priakhina, KE | 1 |
| Malkin, MP | 1 |
| Kalugina, AV | 1 |
| Tatar, A | 1 |
| Korkmaz, M | 1 |
| Yayla, M | 1 |
| Gozeler, MS | 1 |
| Mutlu, V | 1 |
| Halici, Z | 1 |
| Uslu, H | 1 |
| Korkmaz, H | 1 |
| Selli, J | 1 |
| Piechota-Polanczyk, A | 1 |
| Zielińska, M | 1 |
| Piekielny, D | 1 |
| Fichna, J | 1 |
| Yorek, MS | 1 |
| Obrosov, A | 1 |
| Shevalye, H | 1 |
| Coppey, LJ | 1 |
| Kardon, RH | 1 |
| Yorek, MA | 1 |
| El-Shitany, NA | 1 |
| El-Masry, SA | 1 |
| El-Ghareib, MA | 1 |
| El-Desoky, K | 1 |
| Kovrazhkina, EA | 1 |
| Marracci, GH | 1 |
| Jones, RE | 1 |
| McKeon, GP | 1 |
| Bourdette, DN | 1 |
| Park, SJ | 1 |
| Seo, SW | 1 |
| Choi, OS | 1 |
| Park, CS | 1 |
| Schreibelt, G | 1 |
| Musters, RJ | 1 |
| Reijerkerk, A | 1 |
| de Groot, LR | 1 |
| van der Pol, SM | 1 |
| Hendrikx, EM | 1 |
| Döpp, ED | 1 |
| Dijkstra, CD | 1 |
| Drukarch, B | 1 |
| de Vries, HE | 1 |
| Savvov, VI | 1 |
| Karpov, LM | 1 |
| Yamamoto, H | 1 |
| Watanabe, T | 1 |
| Mizuno, H | 1 |
| Endo, K | 1 |
| Fukushige, J | 1 |
| Hosokawa, T | 1 |
| Kazusaka, A | 1 |
| Fujita, S | 1 |
| Chekunova, MP | 1 |
| Minkina, NA | 1 |
| Suvorov, IM | 1 |
| Heilmeyer, L | 1 |
| Beck, K | 1 |
| Finestone, AJ | 1 |
| Berman, R | 1 |
| Widmer, B | 1 |
| Markowitz, J | 1 |
| Laquer, UJ | 1 |
| Ilinich, VK | 1 |
| Plastun, FF | 1 |
| Jakliński, A | 1 |
| Bryc, R | 1 |
| Jaklińska, A | 1 |
| Dabski, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Alpha-Lipoic Acid on the Clinical Outcome of Patients With Sepsis[NCT05808946] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2023-03-10 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for thioctic acid and Acute Disease
| Article | Year |
|---|---|
Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumonia.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carnitine; Chemotherapy, Adjuvant; COVID-19 Drug T | 2021 |
[Treatment of acute hepatic insufficiency (a survey of the literature)].
Topics: Acute Disease; Adenosine Triphosphate; Arginine; Chemical and Drug Induced Liver Injury; Exchange Tr | 1972 |
2 trials available for thioctic acid and Acute Disease
| Article | Year |
|---|---|
Antioxidants Supplementation in Acute Amitriptyline Abuse for Pain.
Topics: Acute Disease; Adult; Amitriptyline; Antioxidants; Ascorbic Acid; Dietary Supplements; Female; Human | 2022 |
α-Lipoic acid treatment of aged type 2 diabetes mellitus complicated with acute cerebral infarction.
Topics: Acute Disease; Aged; Aging; Antioxidants; Ascorbic Acid; Blood Glucose; Cerebral Infarction; Diabete | 2014 |
17 other studies available for thioctic acid and Acute Disease
| Article | Year |
|---|---|
α‑lipoic acid inhibits cerulein/resistin‑induced expression of interleukin‑6 by activating peroxisome proliferator‑activated receptor‑γ in pancreatic acinar cells.
Topics: Acinar Cells; Acute Disease; Animals; Antioxidants; Catalase; Ceruletide; Humans; Interleukin-6; Pan | 2022 |
Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis.
Topics: Acute Disease; Animals; Antioxidants; Brain; Cognitive Dysfunction; Coinfection; Inflammation; Infla | 2017 |
[The effect of 3-oxypyridine and succinic acid derivatives on the resistance to acute cerebral ischemia].
Topics: Acute Disease; Animals; Brain Ischemia; Disease Models, Animal; Female; Male; Meglumine; Mice; Picol | 2014 |
Anti-inflammatory and anti-oxidative effects of alpha-lipoic acid in experimentally induced acute otitis media.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Antioxidants; Glutathione; Guinea Pigs; Malondialdehy | 2016 |
The influence of lipoic acid on caveolin-1-regulated antioxidative enzymes in the mouse model of acute ulcerative colitis.
Topics: Acute Disease; Animals; Antioxidants; Caveolin 1; Colitis, Ulcerative; Colon; Cytokines; Dextran Sul | 2016 |
Early vs. late intervention of high fat/low dose streptozotocin treated C57Bl/6J mice with enalapril, α-lipoic acid, menhaden oil or their combination: Effect on diabetic neuropathy related endpoints.
Topics: Acute Disease; Animals; Chronic Disease; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dru | 2017 |
Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Carrageenan; Cyclooxygenase 2; Cyclooxygenase Inhi | 2010 |
[Demyelinating polyneuropathies in patients with diabetes mellitus and chronic alcoholic intoxication].
Topics: Acute Disease; Alcoholism; Antioxidants; Diabetic Nephropathies; Electromyography; Humans; Polyneuro | 2012 |
Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis.
Topics: Acute Disease; Animals; Antioxidants; Cell Movement; Cells, Cultured; Encephalomyelitis, Autoimmune, | 2002 |
Alpha-lipoic acid protects against cholecystokinin-induced acute pancreatitis in rats.
Topics: Acute Disease; Animals; Cholecystokinin; Hyperlipidemias; Injections, Intraperitoneal; Interleukin-1 | 2005 |
Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity.
Topics: Acute Disease; Animals; Antioxidants; Blood-Brain Barrier; Brain; Capillary Permeability; Cell Line, | 2006 |
[Characteristics of 35S-lipoic acid absorption by the blood cells in breast cancer].
Topics: Absorption; Acute Disease; Adenocarcinoma, Scirrhous; Adenofibroma; Breast Neoplasms; Erythrocytes; | 1982 |
The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats.
Topics: Acute Disease; Administration, Oral; Animals; Antioxidants; Body Weight; Copper; Cytosol; Eating; En | 2001 |
[Pathogenetic therapy procedures in cobalt lesions of the myocardium].
Topics: Acute Disease; Animals; Cobalt; Decanoates; Drug Evaluation, Preclinical; Heart Diseases; Male; Meth | 1978 |
[Therapy of acute viral hepatitis].
Topics: Acute Disease; Adolescent; Adult; Aged; Bilirubin; Biopsy; Cathartics; Diet Therapy; Exchange Transf | 1969 |
Thioctic acid treatment of acute mushroom poisoning.
Topics: Acute Disease; Adolescent; Adult; Child; Female; Humans; Male; Mushroom Poisoning; Thioctic Acid | 1972 |
[Experimental studies on the protective effect of thioctic acid on the liver in acute carbon tetrachloride poisoning].
Topics: Acute Disease; Animals; Carbon Tetrachloride Poisoning; Liver; Mice; Thioctic Acid | 1970 |