thioctic acid has been researched along with Acute Confusional Senile Dementia in 60 studies
Thioctic Acid: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic systemic exposure of mice, rats, and Drosophila to D-galactose causes the acceleration of senescence and has been used as an aging model." | 3.73 | Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. ( Cui, X; Hu, Y; Li, X; Liu, J; Long, J; Packer, L; Zhang, Q; Zuo, P, 2006) |
| "Memoquin (9) is a quinone-bearing polyamine endowed with a unique multifunctional profile." | 2.45 | MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond. ( Andrisano, V; Bartolini, M; Bolognesi, ML; Melchiorre, C; Minarini, A; Rosini, M; Tumiatti, V, 2009) |
| "Several clinical studies have shown Alzheimer's disease to be associated with disturbances in glucose metabolism and the subsequent tricarboxylic acid (TCA) cycle-related metabolites like glutamate (Glu), glutamine (Gln), and N-acetylaspartate (NAA)." | 1.40 | Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study. ( Cadenas, E; Díaz Brinton, R; Kanamori, K; Patil, I; Ross, BD; Sancheti, H, 2014) |
| "The approved treatments for Alzheimer's disease (AD) exploit mainly a symptomatic approach based on the use of cholinesterase inhibitors or N-methyl-D-aspartate (NMDA) receptor antagonists." | 1.39 | Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease. ( Cacciatore, I; Cerasa, LS; Cornacchia, C; Di Crescenzo, A; Di Filippo, ES; Di Stefano, A; Fontana, A; Fulle, S; Grilli, M; Laserra, S; Marchi, M; Sozio, P, 2013) |
| "Alzheimer's disease is a progressive neurodegenerative disease that entails impairments of memory, thinking and behavior and culminates into brain atrophy." | 1.39 | Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease. ( Akopian, G; Brinton, RD; Cadenas, E; Sancheti, H; Walsh, JP; Yin, F, 2013) |
| "Oxidative stress may play a key role in Alzheimer's disease (AD) neuropathology." | 1.34 | Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice. ( Bussiere, JR; Hammond, RS; Henson, E; Jones, RE; Montine, TJ; Quinn, JF; Stackman, RW, 2007) |
| " GSH plays a key role in antioxidant defense, and HNE exposure causes an initial depletion of GSH that leads to gradual toxic accumulation of reactive oxygen species." | 1.34 | Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease. ( Abdul, HM; Butterfield, DA, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 21 (35.00) | 29.6817 |
| 2010's | 28 (46.67) | 24.3611 |
| 2020's | 11 (18.33) | 2.80 |
| Authors | Studies |
|---|---|
| Rosini, M | 5 |
| Andrisano, V | 4 |
| Bartolini, M | 4 |
| Bolognesi, ML | 5 |
| Hrelia, P | 2 |
| Minarini, A | 3 |
| Tarozzi, A | 2 |
| Melchiorre, C | 5 |
| Metsla, K | 1 |
| Kirss, S | 1 |
| Laks, K | 1 |
| Sildnik, G | 1 |
| Palgi, M | 1 |
| Palumaa, T | 1 |
| Tõugu, V | 1 |
| Palumaa, P | 1 |
| Staykov, H | 1 |
| Lazarova, M | 1 |
| Hassanova, Y | 1 |
| Stefanova, M | 1 |
| Tancheva, L | 1 |
| Nikolov, R | 1 |
| Dieter, F | 1 |
| Esselun, C | 1 |
| Eckert, GP | 1 |
| Lv, SY | 1 |
| He, S | 1 |
| Ling, XL | 1 |
| Wang, YQ | 1 |
| Huang, C | 1 |
| Long, JR | 1 |
| Wang, JQ | 1 |
| Qin, Y | 1 |
| Wei, H | 1 |
| Yu, CY | 1 |
| Collins, AE | 1 |
| Saleh, TM | 1 |
| Kalisch, BE | 1 |
| Zhang, J | 1 |
| Zhao, Y | 1 |
| Zhang, Y | 1 |
| Gao, Y | 1 |
| Li, S | 1 |
| Chang, C | 1 |
| Gao, X | 1 |
| Zhao, J | 1 |
| Yang, G | 1 |
| Basile, GA | 1 |
| Iannuzzo, F | 1 |
| Xerra, F | 1 |
| Genovese, G | 1 |
| Pandolfo, G | 1 |
| Cedro, C | 1 |
| Muscatello, MRA | 1 |
| Bruno, A | 1 |
| Pagoni, A | 1 |
| Marinelli, L | 2 |
| Di Stefano, A | 6 |
| Ciulla, M | 1 |
| Turkez, H | 2 |
| Mardinoglu, A | 1 |
| Vassiliou, S | 1 |
| Cacciatore, I | 3 |
| Dos Santos, SM | 1 |
| Romeiro, CFR | 1 |
| Rodrigues, CA | 1 |
| Cerqueira, ARL | 1 |
| Monteiro, MC | 1 |
| Zarini-Gakiye, E | 1 |
| Vaezi, G | 1 |
| Parivar, K | 1 |
| Sanadgol, N | 1 |
| Pei, X | 1 |
| Hu, F | 1 |
| Luo, F | 1 |
| Huang, X | 1 |
| Li, X | 2 |
| Xing, S | 1 |
| Long, D | 1 |
| Kaur, D | 1 |
| Behl, T | 1 |
| Sehgal, A | 1 |
| Singh, S | 1 |
| Sharma, N | 1 |
| Chigurupati, S | 1 |
| Alhowail, A | 1 |
| Abdeen, A | 1 |
| Ibrahim, SF | 1 |
| Vargas-De-La-Cruz, C | 1 |
| Sachdeva, M | 1 |
| Bhatia, S | 1 |
| Al-Harrasi, A | 1 |
| Bungau, S | 1 |
| Zhang, YH | 1 |
| Wang, DW | 1 |
| Xu, SF | 1 |
| Zhang, S | 1 |
| Fan, YG | 1 |
| Yang, YY | 1 |
| Guo, SQ | 1 |
| Wang, S | 2 |
| Guo, T | 1 |
| Wang, ZY | 1 |
| Guo, C | 1 |
| Jalili-Baleh, L | 1 |
| Forootanfar, H | 1 |
| Küçükkılınç, TT | 1 |
| Nadri, H | 1 |
| Abdolahi, Z | 1 |
| Ameri, A | 1 |
| Jafari, M | 1 |
| Ayazgok, B | 1 |
| Baeeri, M | 1 |
| Rahimifard, M | 1 |
| Abbas Bukhari, SN | 1 |
| Abdollahi, M | 1 |
| Ganjali, MR | 1 |
| Emami, S | 1 |
| Khoobi, M | 1 |
| Foroumadi, A | 1 |
| Zara, S | 3 |
| De Colli, M | 1 |
| Rapino, M | 2 |
| Pacella, S | 1 |
| Nasuti, C | 3 |
| Sozio, P | 4 |
| Cataldi, A | 3 |
| Cerasa, LS | 2 |
| Laserra, S | 1 |
| Cornacchia, C | 1 |
| Di Filippo, ES | 1 |
| Fulle, S | 1 |
| Fontana, A | 1 |
| Di Crescenzo, A | 1 |
| Grilli, M | 1 |
| Marchi, M | 1 |
| Sancheti, H | 3 |
| Akopian, G | 1 |
| Yin, F | 1 |
| Brinton, RD | 1 |
| Walsh, JP | 1 |
| Cadenas, E | 3 |
| Hardas, SS | 1 |
| Sultana, R | 1 |
| Clark, AM | 1 |
| Beckett, TL | 1 |
| Szweda, LI | 2 |
| Murphy, MP | 1 |
| Butterfield, DA | 3 |
| Shinto, L | 1 |
| Quinn, J | 1 |
| Montine, T | 1 |
| Dodge, HH | 1 |
| Woodward, W | 1 |
| Baldauf-Wagner, S | 1 |
| Waichunas, D | 1 |
| Bumgarner, L | 1 |
| Bourdette, D | 1 |
| Silbert, L | 1 |
| Kaye, J | 1 |
| Kanamori, K | 2 |
| Patil, I | 2 |
| Díaz Brinton, R | 2 |
| Ross, BD | 1 |
| Ma, QL | 1 |
| Zuo, X | 1 |
| Yang, F | 1 |
| Ubeda, OJ | 1 |
| Gant, DJ | 1 |
| Alaverdyan, M | 1 |
| Kiosea, NC | 1 |
| Nazari, S | 1 |
| Chen, PP | 1 |
| Nothias, F | 1 |
| Chan, P | 1 |
| Teng, E | 1 |
| Frautschy, SA | 1 |
| Cole, GM | 1 |
| Zhang, W | 1 |
| Lin, AL | 1 |
| Gonzalez, P | 1 |
| da Costa, VC | 1 |
| Hyde, K | 1 |
| Wu, Q | 1 |
| Annunziata, O | 1 |
| Rizo, J | 1 |
| Akkaraju, G | 1 |
| Green, KN | 2 |
| Chen, W | 1 |
| Wu, Y | 1 |
| Zhong, S | 1 |
| Cheng, L | 1 |
| Li, Q | 1 |
| Tang, H | 1 |
| Kuhla, A | 1 |
| Ludwig, SC | 1 |
| Kuhla, B | 1 |
| Münch, G | 4 |
| Vollmar, B | 1 |
| Digiacomo, M | 1 |
| Chen, Z | 1 |
| Lapucci, A | 1 |
| Macchia, M | 1 |
| Yang, X | 1 |
| Chu, J | 1 |
| Han, Y | 1 |
| Pi, R | 1 |
| Rapposelli, S | 1 |
| Rodriguez-Perdigon, M | 1 |
| Solas, M | 1 |
| Moreno-Aliaga, MJ | 1 |
| Ramirez, MJ | 1 |
| Fornasari, E | 1 |
| Eusepi, P | 1 |
| Pomilio, C | 1 |
| Reale, M | 1 |
| D'Angelo, C | 1 |
| Costantini, E | 1 |
| Erdoğan, ME | 1 |
| Aydın, S | 1 |
| Yanar, K | 1 |
| Mengi, M | 1 |
| Kansu, AD | 1 |
| Cebe, T | 1 |
| Belce, A | 1 |
| Çelikten, M | 1 |
| Çakatay, U | 1 |
| Salinthone, S | 1 |
| Yadav, V | 1 |
| Bourdette, DN | 1 |
| Carr, DW | 1 |
| Siedlak, SL | 2 |
| Casadesus, G | 1 |
| Webber, KM | 1 |
| Pappolla, MA | 1 |
| Atwood, CS | 1 |
| Smith, MA | 3 |
| Perry, G | 3 |
| Suchy, J | 1 |
| Chan, A | 1 |
| Shea, TB | 1 |
| Tumiatti, V | 2 |
| Shenk, JC | 1 |
| Liu, J | 2 |
| Fischbach, K | 1 |
| Xu, K | 1 |
| Puchowicz, M | 1 |
| Obrenovich, ME | 1 |
| Gasimov, E | 1 |
| Alvarez, LM | 1 |
| Ames, BN | 1 |
| Lamanna, JC | 1 |
| Aliev, G | 2 |
| Liu, RT | 1 |
| Lü, QJ | 1 |
| Cavalli, A | 1 |
| Bergamini, C | 1 |
| Fato, R | 1 |
| Lenaz, G | 1 |
| Cho, JY | 1 |
| Um, HS | 1 |
| Kang, EB | 1 |
| Cho, IH | 1 |
| Kim, CH | 1 |
| Cho, JS | 1 |
| Hwang, DY | 1 |
| D'Aurizio, E | 1 |
| Iannitelli, A | 1 |
| Cantalamessa, F | 1 |
| Parachikova, A | 1 |
| Hendrix, C | 1 |
| LaFerla, FM | 1 |
| Ahmed, HH | 1 |
| Lott, IT | 1 |
| Doran, E | 1 |
| Nguyen, VQ | 1 |
| Tournay, A | 1 |
| Head, E | 1 |
| Gillen, DL | 1 |
| Simoni, E | 2 |
| Matera, R | 1 |
| Milelli, A | 1 |
| Galasko, DR | 1 |
| Peskind, E | 1 |
| Clark, CM | 1 |
| Quinn, JF | 2 |
| Ringman, JM | 1 |
| Jicha, GA | 1 |
| Cotman, C | 1 |
| Cottrell, B | 1 |
| Montine, TJ | 2 |
| Thomas, RG | 1 |
| Aisen, P | 1 |
| Farr, SA | 1 |
| Price, TO | 1 |
| Banks, WA | 1 |
| Ercal, N | 1 |
| Morley, JE | 1 |
| Gasic-Milenkovic, J | 1 |
| Loske, C | 1 |
| Lovell, MA | 1 |
| Xie, C | 1 |
| Xiong, S | 1 |
| Markesbery, WR | 1 |
| Pocernich, CB | 1 |
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| Youdim, MB | 1 |
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| Jellinger, K | 1 |
| Beckmann, H | 1 |
| Riederer, P | 1 |
| Bussiere, JR | 1 |
| Hammond, RS | 1 |
| Henson, E | 1 |
| Jones, RE | 1 |
| Stackman, RW | 1 |
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| Hu, Y | 1 |
| Long, J | 1 |
| Packer, L | 1 |
| McIntyre, RS | 1 |
| Soczynska, JK | 1 |
| Lewis, GF | 1 |
| MacQueen, GM | 1 |
| Konarski, JZ | 1 |
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| Hager, K | 2 |
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| Abdul, HM | 1 |
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| Wang, X | 1 |
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| Oliveira, CR | 2 |
| Tabaton, M | 1 |
| Nunomura, A | 1 |
| Zhu, X | 2 |
| Harris, PL | 1 |
| Kenklies, M | 1 |
| McAfoose, J | 1 |
| Zhang, L | 1 |
| Xing, GQ | 1 |
| Barker, JL | 1 |
| Chang, Y | 1 |
| Maric, D | 1 |
| Ma, W | 1 |
| Li, BS | 1 |
| Rubinow, DR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fish Oil and Alpha Lipoic Acid in Mild Alzheimer's Disease[NCT00090402] | Phase 1/Phase 2 | 39 participants (Actual) | Interventional | 2004-04-30 | Completed | ||
| The Effect of Alpha Lipoic Acid on the Incidence and Severity of Radiotherapy-Induced Oral Mucositis in Head and Neck Cancer Patients[NCT05023863] | Phase 2/Phase 3 | 70 participants (Anticipated) | Interventional | 2021-09-01 | Not yet recruiting | ||
| Evaluation of the Safety, Tolerability and Impact on Biomarkers of Anti-Oxidant Treatment of Mild to Moderate Alzheimer's Disease[NCT00117403] | Phase 1 | 75 participants (Anticipated) | Interventional | 2006-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Activities of Daily Living/Instrumental Activities of Daily Living (ADL/IADL) measures an individual's ability to carry out tasks that are important for daily living and capture functional changes. Scores for each question range from 0 (no assistance needed) to 2 (full assistance needed), and were assessed by informant interview. The combination of scores for ADL (ranging from 0-18) and IADL (0-14) is the outcome (0-32), with higher scores indicating lesser ability to carry out daily living tasks. (NCT00090402)
Timeframe: baseline, 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | 4.2 |
| Fish Oil | 0.7 |
| Fish Oil and Lipoic Acid | 0.9 |
The MMSE is a measure of global cognitive function, and scores range from 0-30, with a lower score indicates greater cognitive impairment. (NCT00090402)
Timeframe: baseline, 12 months
| Intervention | units on a scale (Mean) |
|---|---|
| Placebo | -4.64 |
| Fish Oil | -4.27 |
| Fish Oil Plus Lipoic Acid | -1.00 |
F2-isoprostane is a biomarker was used as an effective indicator for detecting a decrease in systemic oxidative damage (oxidative damage in lipids). Urine F2-Isoprostanes were used to avoid ex vivo lipid peroxidation that can occur with plasma samples. (NCT00090402)
Timeframe: baseline, 12 months
| Intervention | nanogram per miligram (Mean) |
|---|---|
| Placebo | 0.40 |
| Fish Oil | -2.02 |
| Fish Oil Plus Lipoic Acid | 0.45 |
10 reviews available for thioctic acid and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Review of lipoic acid: From a clinical therapeutic agent to various emerging biomaterials.
Topics: Alzheimer Disease; Antioxidants; Biocompatible Materials; Humans; Neoplasms; Polyesters; Thioctic Ac | 2022 |
Mitochondrial Dysfunction and Alpha-Lipoic Acid: Beneficial or Harmful in Alzheimer's Disease?
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cytokines; Humans; Inflammation Mediators; | 2019 |
Decrypting the potential role of α-lipoic acid in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Energy Metabolism; Glucose; Glutathione; Humans; Oxidation-Reduction; Th | 2021 |
Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.
Topics: Alzheimer Disease; Animals; Antioxidants; Central Nervous System Diseases; Diabetic Neuropathies; Hu | 2008 |
MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.
Topics: Alkanes; Alzheimer Disease; Animals; Carbazoles; Cholinesterase Inhibitors; Drug Delivery Systems; D | 2009 |
[Progress in the research on multi-target-directed drugs against Alzheimer's disease].
Topics: Alzheimer Disease; Animals; Drug Combinations; Drug Delivery Systems; Drugs, Chinese Herbal; Humans; | 2009 |
Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease.
Topics: Acetylcholinesterase; Alkanes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Enzyme Inhibitors; | 2011 |
Managing psychiatric disorders with antidiabetic agents: translational research and treatment opportunities.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Animals; Bipolar Disorder; Brain; Cognition; Depr | 2006 |
Lipoic acid as a novel treatment for Alzheimer's disease and related dementias.
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents; Antioxidants; Cerebrovascular Circulation; Chelat | 2007 |
Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts.
Topics: Acetylcysteine; Alzheimer Disease; Fibroblasts; Humans; Immunohistochemistry; Mitochondria; Oxidativ | 2007 |
4 trials available for thioctic acid and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
A randomized placebo-controlled pilot trial of omega-3 fatty acids and alpha lipoic acid in Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cognit | 2014 |
Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation.
Topics: alpha-Tocopherol; Alzheimer Disease; Antioxidants; Ascorbic Acid; Down Syndrome; Drug Combinations; | 2011 |
Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; alpha-Tocopherol; Alzheimer Disease; Amyloid be | 2012 |
Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis.
Topics: Aged; Alzheimer Disease; Antioxidants; Cholinesterase Inhibitors; Cognition Disorders; Disease Progr | 2007 |
46 other studies available for thioctic acid and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Rational approach to discover multipotent anti-Alzheimer drugs.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Butyrylcholinesterase; | 2005 |
α-Lipoic Acid Has the Potential to Normalize Copper Metabolism, Which Is Dysregulated in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein | 2022 |
Neuromodulatory Mechanisms of a Memory Loss-Preventive Effect of Alpha-Lipoic Acid in an Experimental Rat Model of Dementia.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Memory Disorders; Rats; Scopolamine; Thioctic Acid | 2022 |
Redox Active α-Lipoic Acid Differentially Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer and Its Control Cells.
Topics: Adenosine Triphosphate; Alzheimer Disease; Cell Line, Tumor; Citrate (si)-Synthase; Humans; Membrane | 2022 |
VANL-100 Attenuates Beta-Amyloid-Induced Toxicity in SH-SY5Y Cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cell Line, Tumor; Humans; Neuroprotective Ag | 2022 |
Alpha lipoic acid treatment in late middle age improves cognitive function: Proteomic analysis of the protective mechanisms in the hippocampus.
Topics: Alzheimer Disease; Animals; Cell Cycle Proteins; Chromatography, Liquid; Cognition; Cytoskeletal Pro | 2023 |
Cognitive and Mood Effect of Alpha-Lipoic Acid Supplementation in a Nonclinical Elder Sample: An Open-Label Pilot Study.
Topics: Alzheimer Disease; Cognition; Cognition Disorders; Dietary Supplements; Humans; Pilot Projects; Thio | 2023 |
Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cell Proliferation; Dose-Response Relationsh | 2020 |
Age and Dose-Dependent Effects of Alpha-Lipoic Acid on Human Microtubule- Associated Protein Tau-Induced Endoplasmic Reticulum Unfolded Protein Response: Implications for Alzheimer's Disease.
Topics: Activating Transcription Factor 6; Alzheimer Disease; Animals; Dose-Response Relationship, Drug; Dro | 2021 |
The neuroprotective effects of alpha-lipoic acid on an experimental model of Alzheimer's disease in PC12 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Neuroprotective Agents; P | 2022 |
α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice.
Topics: Alzheimer Disease; Animals; Cell Death; Disease Models, Animal; Female; Inflammation; Lipid Peroxida | 2018 |
Design, synthesis and evaluation of novel multi-target-directed ligands for treatment of Alzheimer's disease based on coumarin and lipoic acid scaffolds.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Cholinesterase Inhibitors; Choline | 2018 |
Ibuprofen and lipoic acid conjugate neuroprotective activity is mediated by Ngb/Akt intracellular signaling pathway in Alzheimer's disease rat model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Brain; Cyclic AMP Response Element-Bin | 2013 |
Memantine-sulfur containing antioxidant conjugates as potential prodrugs to improve the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cell Line; Excitatory Amino Acid An | 2013 |
Age-dependent modulation of synaptic plasticity and insulin mimetic effect of lipoic acid on a mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Animals; Brain; Disease Models, Animal; Glucose; Insulin; Mice; Mice | 2013 |
Oxidative modification of lipoic acid by HNE in Alzheimer disease brain.
Topics: Aldehydes; Alzheimer Disease; Animals; Brain; Case-Control Studies; Dihydrolipoamide Dehydrogenase; | 2013 |
Reversal of metabolic deficits by lipoic acid in a triple transgenic mouse model of Alzheimer's disease: a 13C NMR study.
Topics: Alzheimer Disease; Animals; Aspartic Acid; Biomarkers; Citric Acid Cycle; gamma-Aminobutyric Acid; G | 2014 |
Loss of MAP function leads to hippocampal synapse loss and deficits in the Morris Water Maze with aging.
Topics: Aging; Alzheimer Disease; Animals; Disease Models, Animal; Docosahexaenoic Acids; Gene Expression Re | 2014 |
Hypermetabolic state in the 7-month-old triple transgenic mouse model of Alzheimer's disease and the effect of lipoic acid: a 13C-NMR study.
Topics: Alzheimer Disease; Animals; Carbon Isotopes; Dietary Supplements; Disease Models, Animal; Glucose; H | 2014 |
Bimodal-hybrid heterocyclic amine targeting oxidative pathways and copper mis-regulation in Alzheimer's disease.
Topics: Alzheimer Disease; Amines; Amyloid; Animals; Cell Line; Copper; Cyclams; Heterocyclic Compounds; Hum | 2014 |
Anti-neurotoxicity effects of oxoisoaporphine-lipoic acid hybrids.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modi | 2014 |
Advanced glycation end products are mitogenic signals and trigger cell cycle reentry of neurons in Alzheimer's disease brain.
Topics: Alzheimer Disease; Animals; Astrocytes; Brain; Cell Cycle; Cells, Cultured; Cyclin D1; Disease Model | 2015 |
Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endope | 2015 |
Lipoic acid improves neuronal insulin signalling and rescues cognitive function regulating VGlut1 expression in high-fat-fed rats: Implications for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cognition; Dietary Fats; Disease Models, Animal; Gene Expression Regulat | 2016 |
Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cel | 2016 |
The effects of lipoic acid on redox status in brain regions and systemic circulation in streptozotocin-induced sporadic Alzheimer's disease model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Cerebral Cortex; Disease Models, An | 2017 |
Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2009 |
Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance.
Topics: Acetylcarnitine; Alzheimer Disease; Animals; Antioxidants; Apolipoproteins E; Cognition Disorders; D | 2009 |
The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.
Topics: Acetylcarnitine; Aging; Alzheimer Disease; Animals; Antioxidants; Apolipoprotein E4; Brain; Cerebrov | 2009 |
Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.
Topics: Alkanes; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Cell Line, Tumor; Drug Design; Elec | 2009 |
The combination of exercise training and alpha-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; bcl-2-Associated X Protein; Brain-D | 2010 |
Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxid | 2010 |
Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.
Topics: Acetylcysteine; Alkaloids; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Ascorbic Acid | 2010 |
Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.
Topics: Alzheimer Disease; Animals; Antioxidants; Biomarkers; Brain; Carnitine; Cholinesterase Inhibitors; D | 2012 |
Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Cyclooxygenase Inhibitors; Disea | 2011 |
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Butyrylcholinesterase; | 2011 |
Effect of alpha-lipoic acid on memory, oxidation, and lifespan in SAMP8 mice.
Topics: Alzheimer Disease; Animals; Antioxidants; Brain; Disease Models, Animal; Glutathione Peroxidase; Glu | 2012 |
Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y.
Topics: Acetylcysteine; Alzheimer Disease; Brain; Cells, Cultured; Estradiol; Free Radicals; Glycation End P | 2003 |
Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Culture Techniques; Free Radicals; | 2003 |
Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease.
Topics: Acrolein; Alzheimer Disease; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; | 2003 |
(r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cadaver; Case-Control Studies; Dementia, Vascular; Enzym | 2004 |
Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice.
Topics: Aging; Alzheimer Disease; Animals; Brain; Female; Hippocampus; Memory; Memory Disorders; Mice; Mice, | 2007 |
Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.
Topics: Aging; Alzheimer Disease; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Cell Differentiatio | 2006 |
Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.
Topics: Acetylcarnitine; Aldehydes; Alzheimer Disease; Animals; Apoptosis; Cell Survival; Cerebral Cortex; C | 2007 |
Autophagocytosis of mitochondria is prominent in Alzheimer disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Autophagy; Brain; Child; Cytoplasm; E | 2007 |
Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Assay; Cell Death; Cell | 2001 |