thiobenzamide and Cocarcinogenesis

Topics: Amides; Animals; Cell Division; Cocarcinogenesis; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Models, Biological; Rats; Rats, Inbred Strains; Thioamides

Topics: Animals; Cocarcinogenesis; Diethylnitrosamine; Female; Liver Neoplasms, Experimental; Rats; Rats, Inbred Strains; Thioamides

Thiobenzamide (TB) administration to rats (1 g/Kg of diet for 4 weeks) 10 days after a single i.p. injection of dimethylnitrosamine promotes the growth of preneoplastic liver lesions as evidenced by the sharp increase in number and area of gamma-glutamyltranspeptidase-positive hepatocellular foci. At the same time the number of the plaque forming cells isolated from the spleen of rats challenged with sheep red blood cell after the completion of a TB cycle is significantly lower than in the controls 5 as well 13 days after immunization. Accordingly, TB could act as immunodepressant in the rat; this should be taken into account as far as the promoting ability of such xenobiotic is concerned.

Topics: Amides; Animals; Carcinogens; Cocarcinogenesis; Diethylnitrosamine; Female; Hemolytic Plaque Technique; Immunosuppressive Agents; Liver Neoplasms, Experimental; Precancerous Conditions; Rats; Rats, Inbred Strains; Thioamides

Thiobenzamide (a thiono-sulfur-containing xenobiotic), when administered to male Sprague-Dawley rats primed with a single low dose of diethylnitrosamine, enhances the number and size of both gamma-glutamyltranspeptidase-positive hepatocellular foci and cholangiofibrotic areas. Its effect seems to be greater than that of the known promoter phenobarbital.

Topics: Amides; Animals; Cocarcinogenesis; Diethylnitrosamine; Liver Neoplasms; Male; Nitrosamines; Phenobarbital; Rats; Rats, Inbred Strains; Thioamides