thiobarbituric-acid and Muscular-Atrophy

thiobarbituric-acid has been researched along with Muscular-Atrophy* in 2 studies

Other Studies

2 other study(ies) available for thiobarbituric-acid and Muscular-Atrophy

Article	Year
Oxidative stress during recovery from muscle atrophy. FEBS letters, 1993, Jul-12, Volume: 326, Issue:1-3 Single ankle joints of male Wistar rats (15-week-old) were immobilized in the extended position for 7 days and remobilized for 5 days after the immobilization period. Atrophic and contralateral soleus, typical slow red muscles, were collected and their levels of thiobarbituric acid-reactive substance (TBARS) and glutathione were measured. Five-day remobilization did not increase muscle weight significantly. However, there were significant increases in TBARS and oxidized glutathione in the recovering muscle, which strongly suggested that enhanced oxidative stress occurred during the recovery from disuse muscle atrophy. Vitamin E injection accelerated the recovery from atrophy, thus showing that oxidative stress slowed it down. Topics: Animals; Glutathione; Immobilization; Male; Muscles; Muscular Atrophy; Organ Size; Oxidation-Reduction; Rats; Rats, Wistar; Thiobarbiturates; Vitamin E	1993
Trace element movement and oxidative stress in skeletal muscle atrophied by immobilization. The American journal of physiology, 1992, Volume: 262, Issue:5 Pt 1 The movements of trace elements and the level of oxidative stress in the soleus, a typical slow red muscle which, atrophied by immobilization, were investigated in designated intervals. Male Wistar rats (14 wk old) whose one ankle joints were immobilized in the extended position were killed after 4, 8, and 12 days. Fe, Zn, Mn, and Cu concentrations and the levels of thiobarbituric acid-reactive substance (TBARS) and glutathione were measured. The rate of atrophy increased rapidly until the 8th day and slowly after that. In whole muscle, Fe concentration kept increasing, and Zn and Mn increased temporarily. Their subcellular distributions also changed; especially, the Fe level of the microsomal fraction kept increasing and reached threefold at 12 days. Increased TBARS and glutathione disulfide and decreased total glutathione indicated the increased oxidative stress in atrophy, which might result from an increased Fe level, especially that of the microsomal fraction. Vitamin E injection lessened the rate of atrophy, which showed that oxidative stress accelerated muscle atrophy. This might be mediated by increased intracellular Ca. Also metallothionein was induced in muscle atrophy. Topics: Animals; Glutathione; Glutathione Disulfide; Hindlimb; Immobilization; Male; Microscopy, Electron; Muscles; Muscular Atrophy; Oxidation-Reduction; Rats; Rats, Inbred Strains; Stress, Physiological; Subcellular Fractions; Thiobarbiturates; Trace Elements	1992

Article

Year

Oxidative stress during recovery from muscle atrophy.

FEBS letters, 1993, Jul-12, Volume: 326, Issue:1-3

Single ankle joints of male Wistar rats (15-week-old) were immobilized in the extended position for 7 days and remobilized for 5 days after the immobilization period. Atrophic and contralateral soleus, typical slow red muscles, were collected and their levels of thiobarbituric acid-reactive substance (TBARS) and glutathione were measured. Five-day remobilization did not increase muscle weight significantly. However, there were significant increases in TBARS and oxidized glutathione in the recovering muscle, which strongly suggested that enhanced oxidative stress occurred during the recovery from disuse muscle atrophy. Vitamin E injection accelerated the recovery from atrophy, thus showing that oxidative stress slowed it down.

Topics: Animals; Glutathione; Immobilization; Male; Muscles; Muscular Atrophy; Organ Size; Oxidation-Reduction; Rats; Rats, Wistar; Thiobarbiturates; Vitamin E

1993

Trace element movement and oxidative stress in skeletal muscle atrophied by immobilization.

The American journal of physiology, 1992, Volume: 262, Issue:5 Pt 1

The movements of trace elements and the level of oxidative stress in the soleus, a typical slow red muscle which, atrophied by immobilization, were investigated in designated intervals. Male Wistar rats (14 wk old) whose one ankle joints were immobilized in the extended position were killed after 4, 8, and 12 days. Fe, Zn, Mn, and Cu concentrations and the levels of thiobarbituric acid-reactive substance (TBARS) and glutathione were measured. The rate of atrophy increased rapidly until the 8th day and slowly after that. In whole muscle, Fe concentration kept increasing, and Zn and Mn increased temporarily. Their subcellular distributions also changed; especially, the Fe level of the microsomal fraction kept increasing and reached threefold at 12 days. Increased TBARS and glutathione disulfide and decreased total glutathione indicated the increased oxidative stress in atrophy, which might result from an increased Fe level, especially that of the microsomal fraction. Vitamin E injection lessened the rate of atrophy, which showed that oxidative stress accelerated muscle atrophy. This might be mediated by increased intracellular Ca. Also metallothionein was induced in muscle atrophy.

Topics: Animals; Glutathione; Glutathione Disulfide; Hindlimb; Immobilization; Male; Microscopy, Electron; Muscles; Muscular Atrophy; Oxidation-Reduction; Rats; Rats, Inbred Strains; Stress, Physiological; Subcellular Fractions; Thiobarbiturates; Trace Elements

1992