thiobarbituric-acid and Intermittent-Claudication

Biomedical research has recently incorporated bioceramics applications into new health care approaches.. This study evaluated the effect of far infrared-emitting bioceramics wraps in the treatment of intermittent claudication.. This is a randomized double-blind placebo-controlled pilot study. Thirty-five patients met the criteria and were randomized into either control (placebo wraps) or bioceramics group (far infrared emitting-ceramics wraps) and assessed over a 90-day period for the following outcomes: six-minute walk test (6MWT), ankle-brachial index (ABI), Flow-mediated arterial dilation (FMD), quality of life and claudication. Oxidative stress and inflammatory biomarkers were measured in plasma of patients.. Intervention induced a decrease in oxidative stress, with significant lower levels of reactive substances to thiobarbituric acid (TBARS), as well as increase in superoxide dismutase and catalase enzyme activities. There was an increase in the environment subscale of the quality of life questionnaire. No statistically significant differences were found in the inflammatory cytokines, 6MWT, ABI and FMV evaluations.. In Sum, FIR treatment improved oxidative stress profile and quality-of-life of patients with intermittent claudication. The study was registered into the ensaiosclinicos.gov.br (Registro Brasileiro de Ensaios Clínicos [ReBEC]) (RBR-7nr6sy register number).

Topics: Ankle Brachial Index; Antioxidants; Biomarkers; Double-Blind Method; Humans; Inflammation; Infrared Rays; Intermittent Claudication; Oxidative Stress; Pilot Projects; Quality of Life; Superoxide Dismutase; Thiobarbiturates; Treatment Outcome; Walking