thiobarbituric-acid has been researched along with Alcoholic-Intoxication* in 2 studies
2 other study(ies) available for thiobarbituric-acid and Alcoholic-Intoxication
| Article | Year |
|---|---|
[Level of substances reacting with 2-thiobarbituric acid in murine blood plasma in acute ethanol poisoning during protection with zinc metallothionein].
Topics: Alcoholic Intoxication; Animals; Lipid Peroxidation; Liver; Malondialdehyde; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Poisoning; Thiobarbiturates | 1995 |
Nonsteroidal antiinflammatory drugs lower ethanol-mediated liver increase in lipids and thiobarbituric acid reactive substances.
Four nonsteroidal antiinflammatory drugs--namely, acetylsalicylic acid, naproxen, nimesulide, and dipyrone--were assayed to search their capability in preventing the hepatic increase of triacylglycerols and thiobarbituric acid reactive substances, as an indication of lipid peroxidation, resulting from the acute intoxication of rats with ethanol. The four antiinflammatory compounds inhibited the ethanol-mediated increase in triacylglycerols and thiobarbituric acid reactive substances. Furthermore, each one of these antiinflammatory drugs produced distinctive actions on blood ethanol levels: a temporal diminution with aspirin and naproxen, no changes with nimesulide, and an increase with dipyrone. It is concluded that the nonsteroidal antiinflammatory drugs contributed to controlling hepatic lipid peroxidation, and hence the oxidative stress promoted by ethanol intoxication. Topics: Alcoholic Intoxication; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dipyrone; Ethanol; Fatty Liver, Alcoholic; Free Radicals; Lipid Metabolism; Lipid Peroxidation; Male; Metabolic Clearance Rate; Naproxen; Rats; Rats, Wistar; Sulfonamides; Thiobarbiturates; Triglycerides | 1993 |