thiobarbituric-acid and AIDS-Related-Complex

The mean plasma content of malondialdehyde (MDA) in 30 patients in different stages of HIV infection was found to be about 30% higher than that in controls. The phenomenon was not correlated to the degree of immunodeficiency and was noted early in the course of the disease. This indicates a higher degree of basal lipid peroxidation, which might contribute to the tissue damage seen in these patients. A new reverse phase liquid chromatography method was used for quantitative measurements of MDA in plasma after reaction of this compound with thiobarbituric acid.

Topics: AIDS-Related Complex; Chromatography, High Pressure Liquid; Female; Free Radicals; HIV Seropositivity; Humans; Lipid Peroxides; Male; Malonates; Malondialdehyde; Thiobarbiturates