thioacetamide and Poisoning

thioacetamide has been researched along with Poisoning* in 7 studies

Other Studies

7 other study(ies) available for thioacetamide and Poisoning

Article	Year
Inhibition of ornithine aminotransferase by 5-fluoromethylornithine: protection against acute thioacetamide intoxication by elevated tissue ornithine levels. Pharmacology & toxicology, 1992, Volume: 70, Issue:5 Pt 1 5-Fluoromethylornithine (5FMOrn) is a selective inactivator of ornithine aminotransferase. Its administration causes a dramatic increase of ornithine concentrations in all tissues. Treatment of mice with 20 mg.kg-1 5FMOrn shortly before or after a lethal dose (600 mg.kg-1, intraperitoneally) of thioacetamide (TAA), followed by a second dose 24 hr later, prevented death of 60% of the mice. Pathologic symptoms of TAA intoxication (liver haemorrhage, elevation of amino acids in blood and tissues, diminution of liver spermidine and spermine concentrations, elevation of the activity of liver enzymes in the plasma) were significantly ameliorated by the treatment. The liver protective action of 5FMOrn is related to the elevation of ornithine concentration, as appears from the fact that other, less selective inactivators of ornithine aminotransferase, also produced some protection against acute intoxication with TAA, but not a structurally related compound with no effect on this enzyme. Topics: Amino Acids; Ammonia; Animals; Biogenic Polyamines; Chemical and Drug Induced Liver Injury; Hemorrhage; Liver Diseases; Male; Mice; Ornithine; Ornithine-Oxo-Acid Transaminase; Pilot Projects; Poisoning; Thioacetamide	1992
[Sensitivity of the antitoxic liver function. Experimental demonstration]. Boletin de la Asociacion Medica de Puerto Rico, 1976, Volume: 68, Issue:7 Topics: Acetamides; Animals; Dogs; Liver; Liver Function Tests; Pentobarbital; Phenobarbital; Poisoning; Thioacetamide	1976
[Effect of Silymarine-N-methylglucamine salt on the microsomal content of cytochrome P-450 in the rat liver in acute thioacetamide intoxication]. Experientia, 1974, Nov-15, Volume: 30, Issue:11 Topics: Acetamides; Animals; Cytochrome P-450 Enzyme System; Male; Microsomes, Liver; Plant Extracts; Plants; Poisoning; Rats; Thioacetamide	1974
Improvement of methods for comparative studies on nuclear volume and DNA-content of nuclei. Experimentelle Pathologie, 1973, Volume: 8, Issue:3 Topics: Cell Nucleus; Chronic Disease; DNA; Humans; Karyometry; Liver; Poisoning; Polyploidy; Thioacetamide	1973
[Two cases of severe thallium poisoning treated with thioacetamide]. Polski tygodnik lekarski, 1957, Jan-28, Volume: 12, Issue:5 Topics: Acetates; Heavy Metal Poisoning; Metals, Heavy; Poisoning; Thallium; Thioacetamide	1957
Desoxyribose nucleic acid (DNA) content and size of rat liver nuclei during thioacetamide intoxication and recovery. Chromosoma, 1955, Volume: 7, Issue:4 Topics: Acetates; Animals; Cell Nucleus; DNA; Liver; Nucleic Acids; Poisoning; Rats; Thioacetamide	1955
[Two cases of thallium poisoning cured by thioacetamide]. Polski tygodnik lekarski, 1955, Apr-12, Volume: 10, Issue:15 Topics: Acetates; Heavy Metal Poisoning; Metals, Heavy; Poisoning; Thallium; Thioacetamide	1955