thienopyrimidine and Pulmonary-Disease--Chronic-Obstructive

thienopyrimidine has been researched along with Pulmonary-Disease--Chronic-Obstructive* in 1 studies

Other Studies

1 other study(ies) available for thienopyrimidine and Pulmonary-Disease--Chronic-Obstructive

Article	Year
Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor. Bioorganic & medicinal chemistry letters, 2009, Oct-15, Volume: 19, Issue:20 We herein report the discovery of a novel class of antagonists of the human adenosine A2B receptor. This low molecular weight scaffold has been optimized to offer derivatives with potential utility for the alleviation of conditions associated with this receptor subtype, such as nociception, diabetes, asthma and COPD. Furthermore, preliminary pharmacokinetic analysis has revealed compounds with profiles suitable for either inhaled or systemic routes of administration. Topics: Adenosine A2 Receptor Antagonists; Administration, Inhalation; Animals; Asthma; Drug Design; Humans; Pulmonary Disease, Chronic Obstructive; Pyrimidines; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B	2009

Article

Year

Discovery and optimization of potent and selective functional antagonists of the human adenosine A2B receptor.

Bioorganic & medicinal chemistry letters, 2009, Oct-15, Volume: 19, Issue:20

We herein report the discovery of a novel class of antagonists of the human adenosine A2B receptor. This low molecular weight scaffold has been optimized to offer derivatives with potential utility for the alleviation of conditions associated with this receptor subtype, such as nociception, diabetes, asthma and COPD. Furthermore, preliminary pharmacokinetic analysis has revealed compounds with profiles suitable for either inhaled or systemic routes of administration.

Topics: Adenosine A2 Receptor Antagonists; Administration, Inhalation; Animals; Asthma; Drug Design; Humans; Pulmonary Disease, Chronic Obstructive; Pyrimidines; Rats; Receptor, Adenosine A2A; Receptor, Adenosine A2B

2009