thienopyrimidine and Neuralgia

thienopyrimidine has been researched along with Neuralgia* in 1 studies

Other Studies

1 other study(ies) available for thienopyrimidine and Neuralgia

Article	Year
Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain. Bioorganic & medicinal chemistry letters, 2009, Jun-15, Volume: 19, Issue:12 Introduction of small unsaturated alkylamino groups at the 4-position of the A-ring of the tricyclic framework (triazafluorenone) afforded extremely potent and selective mGluR1 antagonists with desirable properties. Compounds 11q and 11s are active in the SNL pain model with ED(50)s 3.3 and 6.4 mg/kg respectively. Metabolic outcome of propargyl amino moiety was studied. Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Heterocyclic Compounds, 3-Ring; Humans; Inhibitory Concentration 50; Neuralgia; Pyridines; Pyrimidines; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship	2009

Article

Year

Tricyclic thienopyridine-pyrimidones/thienopyrimidine-pyrimidones as orally efficacious mGluR1 antagonists for neuropathic pain.

Bioorganic & medicinal chemistry letters, 2009, Jun-15, Volume: 19, Issue:12

Introduction of small unsaturated alkylamino groups at the 4-position of the A-ring of the tricyclic framework (triazafluorenone) afforded extremely potent and selective mGluR1 antagonists with desirable properties. Compounds 11q and 11s are active in the SNL pain model with ED(50)s 3.3 and 6.4 mg/kg respectively. Metabolic outcome of propargyl amino moiety was studied.

Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Heterocyclic Compounds, 3-Ring; Humans; Inhibitory Concentration 50; Neuralgia; Pyridines; Pyrimidines; Rats; Receptors, Metabotropic Glutamate; Structure-Activity Relationship

2009