thienopyrimidine has been researched along with Cartilage-Diseases* in 1 studies
1 other study(ies) available for thienopyrimidine and Cartilage-Diseases
| Article | Year |
|---|---|
Thienopyrimidine derivatives prevent cartilage destruction in articular disease.
The effects of a series of thienopyrimidine derivatives on the prevention of cartilage destruction in articular disease were investigated. Anti-degenerative activity was assayed on culture of nasal pig cartilage in the presence or in the absence of interleukin 1beta (IL-1beta). The amount of glycosaminoglycans (GAGs) and the production of nitric oxide (NO) in the culture medium were determined. Some thienopyrimidine derivatives, in the presence of IL-beta, blocked the cartilage breakdown by inhibiting both the NO production and GAGs release in a dose-dependent manner. Topics: Animals; Cartilage Diseases; Cartilage, Articular; Dose-Response Relationship, Drug; Glycosaminoglycans; Interleukin-1; Nitric Oxide; Pyrimidines; Structure-Activity Relationship; Sulfides; Swine | 2001 |