thienopyridine and Blood-Loss--Surgical

The management of dental patients taking either antiplatelet medication, anticoagulant medication or both has been well established in the previous literature. Recently, new generations of drugs have emerged which are becoming increasingly common, including direct thrombin inhibitors, factor X inhibitors and a new class of oral thienopyridines. The implications of these drugs for the dental surgeon are not yet fully known. Awareness remains low and there is very little information available within the literature on safe use during surgery. This review paper aims to provide some guidance for dental practitioners performing invasive procedures. CPD/CLINICAL RELEVANCE: A new generation of anticoagulant and antiplatelet drugs have serious implications for patients undergoing surgery and their use is increasing.

Topics: Anticoagulants; Antithrombins; Blood Loss, Surgical; Factor X; Hemostasis, Surgical; Humans; Oral Surgical Procedures; Platelet Aggregation Inhibitors; Postoperative Hemorrhage; Pyridines