thienopyridine and Arthritis--Rheumatoid

thienopyridine has been researched along with Arthritis--Rheumatoid* in 1 studies

Other Studies

1 other study(ies) available for thienopyridine and Arthritis--Rheumatoid

Article	Year
Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production. Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6 COT (Tpl2 in mice) is a serine/threonine MAP3 kinase that regulates production of TNF-alpha and other pro-inflammatory cytokines such as IL-1beta via the ERK/MAP kinase pathway. As TNF-alpha and IL-1beta are clinically validated targets for therapeutic intervention in rheumatoid arthritis (RA), blocking COT provides a potential avenue for amelioration of disease. Herein we describe identification of a cellular active selective small molecule inhibitor of COT kinase. Topics: Animals; Arthritis, Rheumatoid; Chemistry, Pharmaceutical; Drug Design; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Interleukin-1beta; Ligands; MAP Kinase Kinase Kinases; Mice; Molecular Structure; Proto-Oncogene Proteins; Pyridines; Tumor Necrosis Factor-alpha	2009

Article

Year

Identification of a selective thieno[2,3-c]pyridine inhibitor of COT kinase and TNF-alpha production.

Bioorganic & medicinal chemistry letters, 2009, Mar-15, Volume: 19, Issue:6

COT (Tpl2 in mice) is a serine/threonine MAP3 kinase that regulates production of TNF-alpha and other pro-inflammatory cytokines such as IL-1beta via the ERK/MAP kinase pathway. As TNF-alpha and IL-1beta are clinically validated targets for therapeutic intervention in rheumatoid arthritis (RA), blocking COT provides a potential avenue for amelioration of disease. Herein we describe identification of a cellular active selective small molecule inhibitor of COT kinase.

Topics: Animals; Arthritis, Rheumatoid; Chemistry, Pharmaceutical; Drug Design; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Interleukin-1beta; Ligands; MAP Kinase Kinase Kinases; Mice; Molecular Structure; Proto-Oncogene Proteins; Pyridines; Tumor Necrosis Factor-alpha

2009