thienamycin and Bacterial-Infections

A comparison was made of the use of thienamycin and cefazolin in antimicrobial prophylaxis of patients undergoing major thoracic noncardiac surgery. Fever and failure or success of prophylaxis were used as criteria. Both cefazolin and thienamycin were of the same value in cases of lung resections, while thienamycin was clearly superior in resections of thoracic oesophagus.

Topics: Bacterial Infections; Cefazolin; Esophagus; Female; Humans; Lung; Male; Middle Aged; Postoperative Complications; Premedication; Random Allocation; Thienamycins

The combined model of viral/bacterial infections has been used in the study. Tienamycin and Coparvax have been administered to infected mice. During the time of 3, 6, 9 and 14 days the hemagglutination inhibition reactions, migration inhibition of leukocytes, phagocytic activity and killing effect of the peritoneal exudate granulocytes have been made. The analysis of migration inhibition of leukocytes gave a statistically characteristic answer after using antigen of anatoxin compared to influenza antigen. In the group of animals which were treated with tienamycin and Coparvax a higher percentage of migration inhibition was observed than in the other group are substantial in the reaction of phagocytosis. Generally, a more beneficial influence of the combined treatment with tienamycin and coparvax has been observed.

Topics: Adjuvants, Immunologic; Animals; Bacterial Infections; Bacterial Vaccines; Cell Migration Inhibition; Cell Movement; Corynebacterium; Drug Therapy, Combination; Granulocytes; Leukocytes; Mice; Mice, Inbred BALB C; Phagocytosis; Respiratory Tract Infections; Thienamycins; Virus Diseases

The effect of tienamycin on selected parameters of the immunological system in mice infected with the influenza virus and Staphylococcus aureus was studied. Tienamycin was administered 24 hours, 2 hours prior the infection and 2 hours after the infection (model I), 24 hours and 48 hours after infecting the mice (model II). The authors analysed phagocytosis, bactericidal activity of peritoneal exudate cells and the LIF release induced by the staphylococcus antigen and the viral antigen by the spleen mice leukocytes. The authors found that the antibiotic given to non-infected mice inhibited phagocytosis of staphylococci by the peritoneal exudate cells. In mice that were infected a positive effect of the antibiotic on all studied parameters. Administering the antibiotic before infecting the mice produced an even better effect.

Topics: Animals; Bacterial Infections; Haemophilus Infections; Haemophilus influenzae; Immunity, Cellular; Mice; Mice, Inbred BALB C; Respiratory Tract Infections; Staphylococcus; Thienamycins

An antimetabolite, THX, was isolated from fermentation broths of the thienamycin producer, Streptomyces cattleya, when the organism was grown in the presence of a fluorine-containing substrate. THX was subsequently identified as one of the four possible stereoisomers of 4-fluorothreonine. Inorganic fluoride or any one of a number of organofluorine compounds can be used as precursors of 4-fluorothreonine. In addition, 19F NMR has provided evidence that the organism synthesizes fluoroacetate under the same fermentation conditions. The in vitro antibacterial spectrum of 4-fluorothreonine is also presented.

Topics: Animals; Anti-Bacterial Agents; Antimetabolites; Bacterial Infections; Fluoroacetates; Magnetic Resonance Spectroscopy; Mice; Pseudomonas aeruginosa; Stereoisomerism; Streptomyces; Thienamycins; Threonine