thiazolidines has been researched along with Disease Models, Animal in 102 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (5.88) | 18.7374 |
| 1990's | 15 (14.71) | 18.2507 |
| 2000's | 20 (19.61) | 29.6817 |
| 2010's | 50 (49.02) | 24.3611 |
| 2020's | 11 (10.78) | 2.80 |
| Authors | Studies |
|---|---|
| DiPrimio, N; Iyer, S; Lao, J; Morava, E; Murthy, K; Parton, Z; Perlstein, EO; Preston, G; Sam, FS; Tsang, H; Verheijen, J | 1 |
| Ajayi, AM; Ben-Azu, B; Emokpae, O; Umukoro, S | 1 |
| Chen, X; Duan, T; Koprivica, V; Lee, S; Levin, MH; Pasricha, ND; Schallhorn, JM; Verkman, AS; Zhang, T | 1 |
| Cha, PH; Cho, YH; Choi, KY; Kim, JY; Lee, JD; Paik, S; Park, JC; Ryu, WJ; Sohn, JH | 1 |
| Chen, HZ; Gao, RF; Gao, Y; Li, X; Luo, W; Lv, CY; Sun, XL; Tang, YH; Xiang, HY; Yang, H; Yang, JS; Yang, YQ | 1 |
| Li, Y; Liu, S; Nie, Y; Sun, K; Wang, H; Wang, X; Zhou, Y | 1 |
| D'Ascenzo, N; Han, S; He, Z; Hu, X; Jacob, C; Liang, X; Liu, Q; Ni, J; Wan, L; Xiao, P; Xiao, W; Xie, Q | 1 |
| Abbas, M; Al Kury, LT; Alam, M; Alghamdi, S; Khan, AU; Li, S; Malik, Z; Nadeem, H; Sahibzada, MUK; Shah, FA | 1 |
| Anderson, JC; Aye, JM; Beierle, EA; Bownes, LV; Marayati, R; Quinn, CH; Stafman, LL; Stewart, JE; Willey, CD; Williams, AP; Yoon, KJ | 1 |
| Cao, Y; Chen, J; Chen, X; Fu, M; Gao, X; Lu, F; Ma, L; Song, Y; Wang, G; Wang, Y; Yang, D; Zhan, Q; Zhang, W; Zheng, L | 1 |
| Chen, D; He, Y; Lin, Z; Zhang, Y | 1 |
| Chen, Q; Dong, R; Fan, Y; Lu, Y; Xue, G; Yuan, H | 1 |
| Fukuda, D; Higashikuni, Y; Hirata, Y; Salim, HM; Sata, M; Shimabukuro, M; Soeki, T; Tanaka, K; Yagi, S | 1 |
| Fu, AK; Fu, LQ; Hu, SL; Li, WF; Li, YL; Wang, YY; Wu, YP | 1 |
| Aonuma, K; Ishizu, T; Kawakami, Y; Kimura, T; Murakoshi, N; Sai, S; Seo, Y; Suto, Y; Xu, D; Yamamoto, M | 1 |
| Chen, Y; Cheng, J; Deng, X; He, H; Huang, W; Jiang, H; Jiang, W; Jin, T; Liu, Q; Tao, J; Wang, A; Wang, C; Ye, J; Zhou, R | 1 |
| Cuello, AC; Ducatenzeiler, A; Fisher, A; Flores Aguilar, L; Gubert, P; Hall, H; Iulita, MF | 1 |
| Ichiki, T; Takahara, Y; Tokunou, T | 1 |
| Goswami, K; Hande, S; Mandvikar, A; Rami Reddy, MV; Togre, N | 1 |
| Choi, JW; Gaire, BP; Song, MR | 1 |
| Bhutani, R; Husain, A; Iqbal, MA; Kapoor, G; Pathak, DP | 1 |
| Abayasiriwardana, KS; Birnie, KA; Laurent, GJ; McAnulty, RJ; Mutsaers, SE; Prêle, CM; Robinson, BW; Wood, MK | 1 |
| Bitschar, K; Dehmer, H; Focken, J; Götz, F; Grond, S; Kalbacher, H; Konnerth, M; Krismer, B; Kurschus, FC; Moos, S; Peschel, A; Sauer, B; Schilling, NA; Schittek, B | 1 |
| Ébert, A; Flodström-Tullberg, M; Harkin, S; Hasib, A; Irwin, N; Kelly, C; Kelsey, R; Khan, D; Maheshwari, RR; Manderson Koivula, FN; McClenaghan, NH; Shaw, JA; Stone, VM; Venglovecz, V; Watson, A; White, MG | 1 |
| Cao, G; Chen, G; Hu, J; Li, X; Liang, G; Shen, X; Tang, Q; Wang, Y; Wei, X; Wu, X; Zhang, X | 1 |
| Akasaka, Y; Ishii, T; Kimura, S; Kuwano, K; Misonoo, Y; Saga, T; Saito, K; Tateda, K; Yamaguchi, K; Yoshizawa, S | 1 |
| Huang, B; Huang, S; Kasper, LH; Li, YQ; Lu, F; Lun, ZR; Shen, J; Wang, Y; Zhao, Y; Zheng, H | 1 |
| Li, C; Li, X; Liu, X; Yan, B; Zhang, Q; Zhou, H | 1 |
| Arthur, PG; Boyatzis, A; Grounds, MD; Terrill, JR | 1 |
| Attardo, G; Bachand, K; Bergeron, MJ; Bonin, RP; Boudreau, D; Castonguay, A; Coull, JA; De Koninck, Y; Dumas, L; Gagnon, M; Isenring, P; Jacob-Wagner, M; Kianicka, I; Lavertu, G; Perez-Sanchez, J; Tardif, C; Tripathy, S; Valade, I; Wang, B | 1 |
| Mameli, C; Zuccotti, GV | 1 |
| Koriyama, H; Kurinami, H; Morishita, R; Moritani, T; Nakagami, H; Pang, Z; Shimamura, M; Shimosato, T; Tenma, A | 1 |
| N'Gouemo, P; Quansah, H | 1 |
| Khan, FA; Mulay, A; Nikalje, AP; Sangshetti, JN; Shaikh, S; Shaikh, SI | 1 |
| Alarcón-Aguilar, FJ; Almanza-Pérez, JC; Estrada-Soto, S; Hidalgo-Figueroa, S; León-Rivera, I; Medina-Franco, JL; Navarrete-Vázquez, G; Ramírez-Espinosa, JJ; Torres-Gómez, H | 1 |
| Kakehashi, A; Kinoshita, N; Matsumoto, T; Ota, A; Shimmura, M; Takano, H; Tanaka, Y; Toyoda, F; Tsuji, J | 1 |
| Kalam Khan, FA; Nikalje, APG; Sangshetti, JN; Shaikh, AN; Shaikh, SI; Shinde, DB | 1 |
| Loureiro, AI; Sierra-Marcuño, G; Sierra-Paredes, G; Soares-da-Silva, P; Wright, LC | 1 |
| Ansari, A; Bari, S; Nikalje, AP; Ugale, V | 1 |
| Avoli, M; Hamidi, S | 1 |
| Ishii, Y; Ito, T; Kashimura, A; Saito, S; Sameshima, A; Sasahara, M; Sasaoka, T; Sawakawa, K; Tsuneki, H; Wada, T; Yonezawa, R | 1 |
| Chirayil, MT; Karot, SS; Kishore, A; Mathew, G; Mudgal, J; Nampurath, GK; Nandakumar, K; Surenahalli, VG | 1 |
| Bar-Ner, N; Bezprozvanny, I; Brandeis, R; Elkon, H; Fisher, A; Gershonov, E; LaFerla, FM; Medeiros, R; Nahum, V; Natan, N; Ryskamp, DA; Wu, L | 1 |
| Arthur, PG; Graves, JA; Grounds, MD; Pinniger, GJ; Terrill, JR | 1 |
| Ideta, T; Kochi, T; Miyazaki, T; Moriwaki, H; Sakai, H; Shimizu, M; Shirakami, Y | 1 |
| Kraft, AS; Sainz, AG; Song, JH; Warfel, NA | 1 |
| Aoyama, M; Bando, YK; Kawase, H; Monji, A; Murohara, T; Nishimura, K | 1 |
| Berscheid, A; Brötz-Oesterhelt, H; Burian, M; Grond, S; Janek, D; Kalbacher, H; Konnerth, MC; Krismer, B; Laux, C; Marschal, M; Peschel, A; Schilling, NA; Schittek, B; Slavetinsky, C; Weidenmaier, C; Willmann, M; Zipperer, A | 1 |
| Chan, GCW; Chan, KW; Huang, XR; Lai, KN; Lan, HY; Tang, SCW; Wu, HJ; Yiu, WH; Zou, A | 1 |
| Gonzalez, FJ; Isom, HC; Kang, BH; Kennett, MJ; McDevitt, EI; Murray, IA; Palkar, PS; Perdew, GH; Peters, JM; Shan, W | 1 |
| da Silva, TG; Dalla Costa, T; de Lima, Mdo C; Galdino, SL; Pitta, Ida R; Uchôa, Fde T | 1 |
| Chandra, JN; Kavitha, CV; Rangappa, KS; Sadashiva, CT; Subhash, MN; Thimmegowda, A | 1 |
| Ahsan, W; Arshad, MF; Khan, SA; Siddiqui, N | 1 |
| Burgess, JD; Fang, D; Jiang, D; Kelley, TJ; Manson, ME; Previs, SF; Ruddy, J; Sonawane, ND; West, RH | 1 |
| Breschi, MC; Calderone, V; Da Settimo, F; La Motta, C; Martelli, A; Sartini, S; Testai, L | 1 |
| Al Moutaery, M; Al Rayes, H; Al Swailam, R; Arshaduddin, M; Elfaki, I; Khan, HA; Tariq, M | 1 |
| De la Fuente, M | 1 |
| Ahn, JH; Bae, MA; Jun, MA; Kang, NS; Kang, SK; Kim, KR; Kim, KY; Kim, MS; Kim, SS; Lee, JO; Park, WS; Rhee, SD; Schneider, SE; Shin, MS; Silinski, P; Song, DH; Yoo, SE | 1 |
| Fan, X; Guidot, DM; Joshi, PC; Koval, M | 1 |
| Bertoni, C; Jung, ME; Kayali, R; Khitrov, G; Ku, JM; Prikhodko, O | 1 |
| Alagarsamy, V; Senthilraja, M | 1 |
| N'Gouemo, P | 1 |
| Amjad, R; Chadhury, MN; Khan, K; Naeem, M; Rehaman, S | 1 |
| Hu, W; Liu, J; Liu, X; Wang, J; Wang, S; Wang, X; Xu, B | 1 |
| De La Fuente, M; Ferrández, MD; Guayerbas, N; Puerto, M | 1 |
| Kawakami, M; Kuroki, M | 1 |
| Makita, Z; Takeuchi, M; Yamagishi, S | 1 |
| Aoyama, I; Enomoto, A; Nakamura, S; Niwa, T; Tachikawa, T; Takayama, F; Tobita, K | 1 |
| Baek, SY; Chung, BS; Kang, CD; Kim, JY; Kim, SD; Kim, SH; Park, KH; Park, SW | 1 |
| Choi, IW; Im, MJ; Kim, UH; Lee, HK; Lee, KS; Lee, YC; Lim, JS; Park, HS; Park, KH; Park, SJ | 1 |
| Inoue, Y; Ito, K; Iwamoto, T; Kita, S; Sakaue, T | 1 |
| Cooper, ME; Coughlan, MT; Forbes, JM | 1 |
| Chandra, JN; Malviya, M; Rangappa, KS; Sadashiva, CT; Subhash, MN | 1 |
| Brown, LA; Guidot, DM; Otis, JS | 1 |
| Fujimura, T; Kinami, S; Miwa, K; Miyashita, T; Oba, M; Sasaki, S | 1 |
| Bruscia, E; Caputo, C; Egan, ME; Ferreira, EC; Krause, DS; Price, JE; Weiner, SA | 1 |
| Dubinion, JH; Jackson, EK; Mi, Z | 1 |
| Dikalov, S; Guidot, DM; Hart, CM; Jones, DP; Kleinhenz, DJ; Kline, ER; Liang, B; Sutliff, RL | 1 |
| Cresta, MA; Tiscornia, OM; Tumilasci, O; Waisman, H | 1 |
| Antolik, EK; Faison, EP; Yarbrough, GG | 1 |
| Arima, M; Makino, S; Yukawa, T | 1 |
| Bartsch, H; Brouet, I; Calmels, S; Ohshima, H; Wu, Y | 1 |
| Aufricht, C; Hayde, M; Höger, H; Lubec, B; Lubec, G; Mallinger, WR; Rokitansky, A; Wagner, U | 1 |
| Holahan, MA; Lynch, JJ; Lynch, RJ; Manno, PD; Mellott, MJ; Ramjit, DR; Sitko, GR; Stabilito, II; Stranieri, MT; Zhang, G | 1 |
| Ceserani, R; Dalla Rosa, C; Gallico, L; Oggioni, N; Tognella, S | 1 |
| Johno, M; Murakami, K; Okabe, H; Okajima, K; Takatsuki, K; Uchiba, M | 1 |
| Hirayama, R; Niigata, K; Noshiro, O; Shikama, H; Shimaya, A; Yoneta, T | 1 |
| Fujii, W; Ishikawa, S; Kawata, T; Koike, T; Makita, Z; Nakamura, S; Yanagisawa, K; Yasumura, K | 1 |
| Bais, R; Baker, PW; Rofe, AM | 1 |
| Kamei, J; Kashiwazaki, T; Morita, K; Ohsawa, M | 1 |
| Miyata, K; Umeda, M; Yamada, T; Yamano, M | 1 |
| Higure, A; Itoh, H; Katoh, H; Nagafuchi, Y; Nakamura, S; Ohsato, K; Okamoto, K; Okazaki, K; Takeda, S; Todoroki, H | 1 |
| Kamei, J; Morita, K | 1 |
| Bogaty, P; Kingma, JG; Plante, S | 1 |
| Doi, T; Kato, I; Ohashi, S; Okamoto, H; Sakurai, S; Takasawa, S; Takeuchi, M; Watanabe, T; Yamagishi, S; Yamamoto, H; Yamamoto, Y; Yonekura, H | 1 |
| Imanishi, N; Morooka, S; Sugasawa, T; Uchida, M | 1 |
| Imanishi, N; Morooka, S; Sugasawa, T | 1 |
| Horie, M; Mase, T; Nagaoka, H; Sakurai, Y; Tomioka, K; Yamada, T | 1 |
| Kaneto, H; Kojima, M | 1 |
| Black, J; Ip, MM; Shea, WK | 1 |
| Carino, MA; Horita, A; Lai, H | 1 |
| Kador, PF; Kinoshita, JH; Sharpless, NE | 1 |
4 review(s) available for thiazolidines and Disease Models, Animal
| Article | Year |
|---|---|
[Aminoguanidine and other AGE inhibitors].
Topics: Amides; Animals; Arteriosclerosis; Cardiovascular Diseases; Cataract; Clinical Trials as Topic; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Retinopathy; Disease Models, Animal; Drug Design; Glycation End Products, Advanced; Guanidines; Humans; Hydrazines; Hypoglycemic Agents; Thiadiazoles; Thiazoles; Thiazolidines | 2002 |
[OPB-9195].
Topics: Animals; Diabetic Angiopathies; Disease Models, Animal; Drug Design; Glycation End Products, Advanced; Guanidines; Humans; Hypoglycemic Agents; Thiadiazoles; Thiazoles; Thiazolidines | 2002 |
Can advanced glycation end product inhibitors modulate more than one pathway to enhance renoprotection in diabetes?
Topics: Animals; Diabetic Nephropathies; Disease Models, Animal; Glycation End Products, Advanced; Guanidines; Humans; Pyridoxamine; Renin-Angiotensin System; Thiadiazoles; Thiazolidines | 2005 |
Aldose reductase inhibitors: a potential new class of agents for the pharmacological control of certain diabetic complications.
Topics: Aldehyde Reductase; Animals; Binding Sites; Blood Glucose; Cataract; Chemical Phenomena; Chemistry; Corneal Diseases; Diabetes Complications; Diabetes Mellitus; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Disease Models, Animal; Fluorenes; Galactose; Humans; Hydantoins; Imidazoles; Imidazolidines; Models, Molecular; Naphthalenes; Phthalazines; Rhodanine; Sorbitol; Structure-Activity Relationship; Substrate Specificity; Sugar Alcohol Dehydrogenases; Thiazolidines; Tissue Distribution | 1985 |
98 other study(ies) available for thiazolidines and Disease Models, Animal
| Article | Year |
|---|---|
Repurposing the aldose reductase inhibitor and diabetic neuropathy drug epalrestat for the congenital disorder of glycosylation PMM2-CDG.
Topics: Aldehyde Reductase; Animals; Cells, Cultured; Congenital Disorders of Glycosylation; Diabetic Neuropathies; Disease Models, Animal; Drug Repositioning; Endoplasmic Reticulum Stress; Fibroblasts; Glycosylation; Humans; Nematoda; Phosphotransferases (Phosphomutases); Polyphenols; Rhodanine; Thiazolidines | 2019 |
D-Ribose-L-cysteine attenuates lipopolysaccharide-induced memory deficits through inhibition of oxidative stress, release of proinflammatory cytokines, and nuclear factor-kappa B expression in mice.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Cysteine; Cytokines; Disease Models, Animal; Inflammation Mediators; Lipopolysaccharides; Male; Maze Learning; Memory; Memory Disorders; Mice; NF-kappa B; Oxidative Stress; Recognition, Psychology; Signal Transduction; Social Behavior; Thiazolidines | 2020 |
Nanomolar Potency Aminophenyltriazine CFTR Activator Reverses Corneal Epithelial Injury in a Mouse Model of Dry Eye.
Topics: Administration, Topical; Animals; Benzoates; Cautery; Chloride Channels; Corneal Injuries; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Dry Eye Syndromes; Female; Lacrimal Apparatus; Lissamine Green Dyes; Mice; Mice, Inbred BALB C; Nanotechnology; Tears; Thiazolidines; Treatment Outcome; Triazines | 2020 |
Destabilization of β-catenin and RAS by targeting the Wnt/β-catenin pathway as a potential treatment for triple-negative breast cancer.
Topics: Animals; Antineoplastic Agents; beta Catenin; Biomarkers; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; ErbB Receptors; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Protein Stability; ras Proteins; Thiazolidines; Triple Negative Breast Neoplasms; Wnt Signaling Pathway; Xenograft Model Antitumor Assays | 2020 |
The covalent NLRP3-inflammasome inhibitor Oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in mice.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Disease Models, Animal; Diterpenes, Kaurane; Fibrosis; Furans; Heterocyclic Compounds, 4 or More Rings; Indenes; Inflammasomes; Interleukin-1beta; Macrophages; Male; Mice, Inbred C57BL; Myocardial Infarction; Myocytes, Cardiac; Neutrophil Infiltration; Neutrophils; NLR Family, Pyrin Domain-Containing 3 Protein; Receptors, Interleukin-18; Signal Transduction; Stroke Volume; Sulfonamides; Sulfones; Thiazolidines; Thiones; Ventricular Function, Left; Ventricular Remodeling | 2021 |
NLRP3 inflammasome inhibitor CY-09 reduces hepatic steatosis in experimental NAFLD mice.
Topics: Animals; Body Weight; Diet, High-Fat; Disease Models, Animal; Insulin Resistance; Male; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Thiazolidines; Thiones; Triglycerides | 2021 |
Effect of Increased IL-1β on Expression of HK in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Line; Disease Models, Animal; Female; Hexokinase; Humans; Indazoles; Interleukin-1beta; Lipopolysaccharides; Mice; Mice, Transgenic; Nigericin; Positron-Emission Tomography; Thiazolidines; Thiones; Up-Regulation | 2021 |
Thiazolidine Derivatives Attenuate Carrageenan-Induced Inflammatory Pain in Mice.
Topics: Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred BALB C; Molecular Structure; Pain; Structure-Activity Relationship; Thiazolidines | 2021 |
PIM kinases mediate resistance to cisplatin chemotherapy in hepatoblastoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Cell Line, Tumor; Cisplatin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Activation; Gene Expression; Hepatoblastoma; Humans; Liver Neoplasms; Mice; Neoplastic Stem Cells; Phenotype; Proto-Oncogene Proteins c-pim-1; Thiazolidines; Xenograft Model Antitumor Assays | 2021 |
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Topics: Animals; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Esophageal Squamous Cell Carcinoma; Extracellular Vesicles; Humans; Male; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Muscular Atrophy; Phosphoglycerate Dehydrogenase; Procollagen-Proline Dioxygenase; Protein Disulfide-Isomerases; Thiazolidines; Thiones | 2021 |
CY-09 attenuates the progression of osteoarthritis via inhibiting NLRP3 inflammasome-mediated pyroptosis.
Topics: Animals; Cartilage; Chondrocytes; Disease Models, Animal; Disease Progression; Extracellular Matrix; Female; Homeostasis; Inflammasomes; Inflammation; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Osteoarthritis; Protective Agents; Pyroptosis; Thiazolidines; Thiones; Tumor Necrosis Factor-alpha | 2021 |
CY-09 Inhibits NLRP3 Inflammasome Activation to Relieve Pain via TRPA1.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium; Computational Biology; Cytokines; Disease Models, Animal; Inflammasomes; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Pain; Pain Measurement; Thiazolidines; Thiones; TRPA1 Cation Channel | 2021 |
Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Anti-Inflammatory Agents; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; Cytokines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Exenatide; Female; Genetic Predisposition to Disease; Incretins; Inflammation Mediators; Macrophage Activation; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Peptides; Phenotype; Plaque, Atherosclerotic; Pyrazoles; RAW 264.7 Cells; Signal Transduction; Thiazolidines; Time Factors; Vasodilation; Venoms | 2017 |
Pidotimod exacerbates allergic pulmonary infection in an OVA mouse model of asthma.
Topics: Animals; Arginase; Asthma; Bronchoalveolar Lavage Fluid; Cell Differentiation; Disease Models, Animal; Down-Regulation; Eosinophils; Female; Hypersensitivity; Immunoglobulin E; Intercellular Signaling Peptides and Proteins; Lung; Metaplasia; Mice, Inbred C57BL; Mucus; Ovalbumin; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Th2 Cells; Thiazolidines | 2017 |
Teneligliptin Prevents Cardiomyocyte Hypertrophy, Fibrosis, and Development of Hypertensive Heart Failure in Dahl Salt-Sensitive Rats.
Topics: Animals; Blood Pressure; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Fibrosis; Heart Failure; Hypertension; Hypertrophy, Left Ventricular; Male; Myocytes, Cardiac; Pyrazoles; Rats; Rats, Inbred Dahl; Thiazolidines; Treatment Outcome; Ventricular Function, Left | 2018 |
Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders.
Topics: Adult; Animals; Cell Line, Tumor; Cryopyrin-Associated Periodic Syndromes; Diabetes Mellitus, Type 2; Disease Models, Animal; HEK293 Cells; Humans; Immunoblotting; Inflammasomes; Inflammation; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; Molecular Structure; NLR Family, Pyrin Domain-Containing 3 Protein; Small Molecule Libraries; Thiazolidines; Thiones | 2017 |
AF710B, an M1/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer's disease.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Cognition Disorders; Disease Models, Animal; Rats; Rats, Transgenic; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Thiazolidines | 2018 |
Suppression of Abdominal Aortic Aneurysm Formation in Mice by Teneligliptin, a Dipeptidyl Peptidase-4 Inhibitor.
Topics: Animals; Aortic Aneurysm, Abdominal; Cells, Cultured; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Macrophages; Male; Mice; Mice, Knockout, ApoE; Pyrazoles; Thiazolidines | 2018 |
Antifilarial actions of green tea extract and a synthetic heterocyclic thiazolidine derivative, Im8 compound in experimental mouse model.
Topics: Animals; Antinematodal Agents; Antioxidants; Disease Models, Animal; Mice; Plant Extracts; Tea; Thiazolidines | 2016 |
Sphingosine 1-phosphate receptor subtype 3 (S1P
Topics: Animals; Brain Injuries; Calcium-Binding Proteins; Cell Polarity; Cells, Cultured; Disease Models, Animal; Fluoresceins; Glial Fibrillary Acidic Protein; Infarction, Middle Cerebral Artery; Lipopolysaccharides; Macrophage Activation; Male; Mice; Mice, Inbred ICR; Microfilament Proteins; Microglia; NF-kappa B; Receptors, Lysosphingolipid; RNA, Small Interfering; Signal Transduction; Sphingosine-1-Phosphate Receptors; Thiazolidines | 2018 |
Novel hybrids of benzothiazole-1,3,4-oxadiazole-4-thiazolidinone: Synthesis, in silico ADME study, molecular docking and in vivo anti-diabetic assessment.
Topics: Administration, Oral; Animals; Benzothiazoles; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glucose Tolerance Test; Hypoglycemic Agents; Male; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Rats; Rats, Wistar; Streptozocin; Structure-Activity Relationship; Thiazolidines | 2019 |
Inhibition of collagen production delays malignant mesothelioma tumor growth in a murine model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Collagen; Disease Models, Animal; Extracellular Matrix; Female; Humans; Inflammation; Lung Neoplasms; Mesothelioma; Mesothelioma, Malignant; Mice; Mice, Inbred CBA; Pleural Neoplasms; Thiazolidines; Transforming Growth Factor beta | 2019 |
Lugdunin amplifies innate immune responses in the skin in synergy with host- and microbiota-derived factors.
Topics: Animals; Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Cathelicidins; Cells, Cultured; Disease Models, Animal; Female; Humans; Immunity, Innate; Keratinocytes; Mice; Mice, Inbred C57BL; Mice, Knockout; Microbiota; Peptides; Peptides, Cyclic; Primary Cell Culture; Skin; Staphylococcal Infections; Staphylococcus aureus; Thiazolidines | 2019 |
Short-term CFTR inhibition reduces islet area in C57BL/6 mice.
Topics: Animals; Benzoates; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Diabetes Mellitus; Disease Models, Animal; Humans; Insulin; Insulin-Secreting Cells; Male; Mice; Thiazolidines | 2019 |
Synthesis and biological evaluation of novel thiazolidinone derivatives as potential anti-inflammatory agents.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship, Drug; Interleukin-6; Lipopolysaccharides; Macrophages; Mice; Molecular Structure; Structure-Activity Relationship; Survival Rate; Thiazolidines; Tumor Necrosis Factor-alpha | 2013 |
Protective effect of procysteine on Acinetobacter pneumonia in hyperoxic conditions.
Topics: Acinetobacter Infections; Administration, Intranasal; Animals; Antioxidants; Bacterial Load; Cytokines; Disease Models, Animal; Female; Histocytochemistry; Lung; Macrophages, Alveolar; Mice; Mice, Inbred BALB C; Phagocytosis; Pneumonia, Ventilator-Associated; Pyrrolidonecarboxylic Acid; Thiazolidines; Treatment Outcome | 2013 |
Evaluation of the adjuvant effect of pidotimod on the immune protection induced by UV-attenuated Toxoplasma gondii in mouse models.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Protozoan; Antigens, Protozoan; Cytokines; Disease Models, Animal; Female; Humans; Immunoglobulin G; Injections, Intraperitoneal; Liver; Mice; Protozoan Proteins; Protozoan Vaccines; Pyrrolidonecarboxylic Acid; Species Specificity; Specific Pathogen-Free Organisms; Spleen; Thiazolidines; Toxoplasma; Toxoplasmosis; Ultraviolet Rays; Vaccination; Vaccines, Attenuated | 2013 |
Antitumor activity of (2E,5Z)-5-(2-hydroxybenzylidene)-2-((4-phenoxyphenyl)imino) thiazolidin-4-one, a novel microtubule-depolymerizing agent, in U87MG human glioblastoma cells and corresponding mouse xenograft model.
Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Division; Cell Proliferation; Dacarbazine; Disease Models, Animal; G2 Phase Cell Cycle Checkpoints; Glioblastoma; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubules; Neoplasm Transplantation; Phenyl Ethers; Temozolomide; Thiazolidines; Tubulin Modulators; Tumor Cells, Cultured | 2013 |
Treatment with the cysteine precursor l-2-oxothiazolidine-4-carboxylate (OTC) implicates taurine deficiency in severity of dystropathology in mdx mice.
Topics: Acetylcysteine; Animals; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Muscular Dystrophy, Duchenne; Oxidative Stress; Pyrrolidonecarboxylic Acid; Taurine; Thiazolidines | 2013 |
Chloride extrusion enhancers as novel therapeutics for neurological diseases.
Topics: Analgesics; Animals; Chlorides; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; HEK293 Cells; High-Throughput Screening Assays; Humans; Intracellular Fluid; Ion Transport; K Cl- Cotransporters; Male; Nervous System Diseases; Neuralgia; Rats; Rats, Sprague-Dawley; Symporters; Thiazolidines | 2013 |
Pidotimod: the past and the present.
Topics: Acute Disease; Adaptive Immunity; Adjuvants, Immunologic; Animals; Child; Child, Preschool; Cohort Studies; Disease Models, Animal; Female; Forecasting; Humans; Immunity, Innate; Incidence; Male; Pyrrolidonecarboxylic Acid; Respiratory Tract Infections; Risk Factors; Secondary Prevention; Thiazolidines; Treatment Outcome | 2013 |
The dipeptidyl peptidase-4 inhibitor teneligliptin improved endothelial dysfunction and insulin resistance in the SHR/NDmcr-cp rat model of metabolic syndrome.
Topics: Aging; Animals; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Endothelium, Vascular; Glucose; Insulin Resistance; Metabolic Syndrome; Pyrazoles; Rats; Rats, Inbred SHR; Thiazolidines | 2014 |
Amiloride and SN-6 suppress audiogenic seizure susceptibility in genetically epilepsy-prone rats.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzyl Compounds; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Reflex; Genetic Predisposition to Disease; Guanidines; Male; Pyrazoles; Rats; Rats, Transgenic; Thiazolidines; Time Factors | 2014 |
Ultrasound-assisted synthesis, anticonvulsant activity, and docking study of indole-appended thiazolidin-4-ones.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Drug Design; Electroshock; Indoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Mice; Molecular Docking Simulation; Molecular Structure; Motor Activity; Neurotoxicity Syndromes; Pentylenetetrazole; Rotarod Performance Test; Seizures; Structure-Activity Relationship; Thiazolidines; Time Factors; Ultrasonics | 2014 |
Synthesis, in vitro and in silico studies of a PPARγ and GLUT-4 modulator with hypoglycemic effect.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Ligands; Mice; Molecular Docking Simulation; Molecular Structure; PPAR gamma; Rats; RNA, Messenger; Thiazolidines | 2014 |
Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats.
Topics: Administration, Oral; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetic Retinopathy; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Glycated Hemoglobin; Male; Neuroprotective Agents; Pyrazines; Rats; Rats, Sprague-Dawley; Retina; Rhodanine; Spiro Compounds; Thiazolidines; Time Factors | 2014 |
Microwave assisted synthesis and docking study of N-(2-oxo-2-(4-oxo-2-substituted thiazolidin-3ylamino)ethyl)benzamide derivatives as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Benzamides; Binding Sites; Disease Models, Animal; Half-Life; Liver; Mice; Microwaves; Molecular Docking Simulation; Motor Activity; Protein Structure, Tertiary; Seizures; Sodium Channels; Thiazolidines | 2014 |
Effects of eslicarbazepine acetate on acute and chronic latrunculin A-induced seizures and extracellular amino acid levels in the mouse hippocampus.
Topics: Acute Disease; Amino Acids; Animals; Anticonvulsants; Aspartic Acid; Bridged Bicyclo Compounds, Heterocyclic; Chronic Disease; Dibenzazepines; Disease Models, Animal; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Glycine; Hippocampus; Male; Mice; Seizures; Taurine; Thiazolidines | 2014 |
Synthesis, Biological Activity, and Docking Study of Novel Isatin Coupled Thiazolidin-4-one Derivatives as Anticonvulsants.
Topics: Animals; Anticonvulsants; Behavior, Animal; Binding Sites; Computer-Aided Design; Disease Models, Animal; Drug Design; Electroshock; Isatin; Ligands; Liver; Male; Mice; Molecular Docking Simulation; Molecular Structure; Pentylenetetrazole; Protein Binding; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship; Thiazolidines | 2015 |
KCC2 function modulates in vitro ictogenesis.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bumetanide; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Antagonists; K Cl- Cotransporters; Male; Rats, Sprague-Dawley; Sodium Potassium Chloride Symporter Inhibitors; Symporters; Thiazoles; Thiazolidines; Thioglycolates; Tissue Culture Techniques | 2015 |
Teneligliptin improves metabolic abnormalities in a mouse model of postmenopausal obesity.
Topics: Aging; Animals; Behavior, Animal; Body Temperature Regulation; Diabetes Mellitus, Type 2; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Energy Metabolism; Female; Intra-Abdominal Fat; Liver; Macrophages; Mice, Inbred C57BL; Motor Activity; Non-alcoholic Fatty Liver Disease; Obesity, Abdominal; Ovariectomy; Panniculitis; Pyrazoles; Thiazolidines | 2015 |
Dose-related antihyperglycemic and hypolipidemic effects of two novel thiazolidin-4-ones in a rodent model of metabolic syndrome.
Topics: Animals; Animals, Newborn; Blood Glucose; Cell Line; Cholesterol; Dietary Sucrose; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hypoglycemic Agents; Hypolipidemic Agents; Interleukin-6; Liver; Macrophages; Male; Metabolic Syndrome; Molecular Structure; Nitric Oxide; Prediabetic State; Rats, Wistar; Reactive Oxygen Species; Sodium Glutamate; Thiazolidines; Triglycerides; Tumor Necrosis Factor-alpha | 2016 |
AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer’s Disease.
Topics: Allosteric Regulation; Alzheimer Disease; Animals; Avoidance Learning; Cerebral Cortex; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Hippocampus; Humans; Male; Maze Learning; Mice, Transgenic; Nootropic Agents; PC12 Cells; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Muscarinic M1; Receptors, sigma; Spiro Compounds; Synapses; Thiazolidines | 2016 |
Increasing taurine intake and taurine synthesis improves skeletal muscle function in the mdx mouse model for Duchenne muscular dystrophy.
Topics: Animals; Disease Models, Animal; Female; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Contraction; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Pyrrolidonecarboxylic Acid; Taurine; Thiazolidines | 2016 |
The Dipeptidyl Peptidase-4 Inhibitor Teneligliptin Attenuates Hepatic Lipogenesis via AMPK Activation in Non-Alcoholic Fatty Liver Disease Model Mice.
Topics: AMP-Activated Protein Kinases; Animals; Biomarkers; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Enzyme Activation; Lipid Metabolism; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Phosphorylation; Pyrazoles; Signal Transduction; Thiazolidines; Triglycerides | 2015 |
PIM Kinase Inhibitors Kill Hypoxic Tumor Cells by Reducing Nrf2 Signaling and Increasing Reactive Oxygen Species.
Topics: Animals; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice; Models, Biological; Neoplasms; NF-E2-Related Factor 2; Prostatic Neoplasms; Protein Binding; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-pim-1; Reactive Oxygen Species; Signal Transduction; Thiazolidines; Xenograft Model Antitumor Assays | 2016 |
A dipeptidyl peptidase-4 inhibitor ameliorates hypertensive cardiac remodeling via angiotensin-II/sodium-proton pump exchanger-1 axis.
Topics: Angiotensin II; Animals; Blood Pressure; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Echocardiography; Heart Failure; Hypertension; Male; Myocytes, Cardiac; Pyrazoles; Rats; Rats, Inbred SHR; Signal Transduction; Sodium-Hydrogen Exchangers; Thiazolidines; Vasodilation; Ventricular Remodeling | 2016 |
Human commensals producing a novel antibiotic impair pathogen colonization.
Topics: Animals; Anti-Bacterial Agents; Carrier State; Disease Models, Animal; Drug Resistance, Microbial; Female; Humans; Male; Mice; Mice, Inbred C57BL; Microbial Sensitivity Tests; Microbiota; Nose; Peptides, Cyclic; Sigmodontinae; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus lugdunensis; Symbiosis; Thiazolidines | 2016 |
N-acetyl-seryl-aspartyl-lysyl-proline mediates the anti-fibrotic properties of captopril in unilateral ureteric obstructed BALB/C mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Disease Models, Animal; Extracellular Matrix Proteins; Fibrosis; Indoles; Kidney; Kidney Diseases; Male; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oligopeptides; Peptidyl-Dipeptidase A; Prolyl Oligopeptidases; Serine Endopeptidases; Serine Proteinase Inhibitors; Signal Transduction; Thiazolidines; Transforming Growth Factor beta1; Ureteral Obstruction | 2018 |
Ligand activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) attenuates carbon tetrachloride hepatotoxicity by downregulating proinflammatory gene expression.
Topics: Animals; Biomarkers; Carbon Tetrachloride; Cell Proliferation; Cells, Cultured; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Inflammation Mediators; Ligands; Liver; Liver Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; PPAR delta; PPAR-beta; Protective Agents; Thiazolidines; Time Factors; Tumor Necrosis Factor-alpha | 2008 |
Preclinical pharmacokinetic and pharmacodynamic evaluation of thiazolidinone PG15: an anti-inflammatory candidate.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Half-Life; Indoles; Indomethacin; Inflammation; Injections, Intravenous; Leukocytes; Male; Mice; Peritonitis; Rats; Rats, Wistar; Thiazolidines; Tissue Distribution | 2009 |
Synthesis and pharmacological evaluation of novel N-alkyl/aryl substituted thiazolidinone arecoline analogues as muscarinic receptor 1 agonist in Alzheimer's dementia models.
Topics: Alzheimer Disease; Animals; Arecoline; Brain; Disease Models, Animal; Male; Memory; Molecular Structure; Muscarinic Agonists; Rats; Rats, Wistar; Receptor, Muscarinic M1; Structure-Activity Relationship; Thiazolidines | 2009 |
Sulfonamide derivatives of thiazolidin-4-ones with anticonvulsant activity against two seizure models: synthesis and pharmacological evaluation.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Ketones; Rats; Seizures; Structure-Activity Relationship; Sulfonamides; Thiazolidines | 2010 |
Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesis.
Topics: Animals; Benzoates; Binding Sites; Cell Line; Cell Membrane; Cholesterol; Cholesterol Oxidase; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Electrochemical Techniques; Epithelial Cells; Genotype; Humans; Hydroxymethylglutaryl-CoA Synthase; Kinetics; Mass Spectrometry; Mice; Mice, Inbred CFTR; Microelectrodes; Mutation; Nasal Mucosa; Phenotype; Promoter Regions, Genetic; Respiratory Mucosa; Resveratrol; Stilbenes; Thiazolidines; Transfection | 2010 |
Anti-ischaemic activity of an antioxidant aldose reductase inhibitor on diabetic and non-diabetic rat hearts.
Topics: Aldehyde Reductase; Animals; Antioxidants; Cardiotonic Agents; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme Inhibitors; Male; Myocardial Reperfusion Injury; Myocardium; Pyridines; Pyrimidinones; Rats; Rats, Wistar; Rhodanine; Thiazolidines | 2010 |
Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Cysteine; Disease Models, Animal; Ethanol; Female; Gastric Mucosa; Male; Prodrugs; Pyrrolidonecarboxylic Acid; Rats; Rats, Wistar; Stomach Ulcer; Thiazolidines | 2012 |
Murine models of premature ageing for the study of diet-induced immune changes: improvement of leucocyte functions in two strains of old prematurely ageing mice by dietary supplementation with sulphur-containing antioxidants.
Topics: Acetylcysteine; Aging, Premature; Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Female; Leukocytes; Mice; Mice, Inbred BALB C; Sulfur; Thiazolidines | 2010 |
Discovery of β-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors.
Topics: Administration, Oral; Animals; Crystallography, X-Ray; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dogs; Enzyme Activation; Inhibitory Concentration 50; Molecular Structure; Rats; Thiazolidines | 2011 |
Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats.
Topics: Alcoholism; Animals; Antioxidants; Central Nervous System Depressants; Comorbidity; Disease Models, Animal; Drug Evaluation, Preclinical; Epithelial Cells; Epithelium; Ethanol; Glutathione; HIV Envelope Protein gp120; HIV Infections; HIV-1; Lung; Lung Diseases; Male; Membrane Proteins; NF-E2-Related Factor 2; Occludin; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Rats, Transgenic; Thiazolidines; Tight Junctions; Time Factors | 2011 |
Read-through compound 13 restores dystrophin expression and improves muscle function in the mdx mouse model for Duchenne muscular dystrophy.
Topics: Animals; Codon, Nonsense; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Dystrophin; Furans; Gentamicins; Injections, Intramuscular; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Fibers, Skeletal; Muscle Strength; Muscle, Skeletal; Muscular Dystrophy, Duchenne; Oxadiazoles; Phenols; Protein Synthesis Inhibitors; Reading Frames; Schiff Bases; Thiazolidines; Transcription, Genetic | 2012 |
Synthesis and pharmacological investigation of 2-(4-dimethylaminophenyl)-3,5-disubstituted thiazolidin-4-ones as anticonvulsants.
Topics: Acetamides; Animals; Anticonvulsants; Benzamides; Diazepam; Disease Models, Animal; Epilepsy; Male; Mice; Structure-Activity Relationship; Thiazolidines | 2012 |
Probing the role of the sodium/calcium exchanger in pentylenetetrazole-induced generalized seizures in rats.
Topics: Animals; Anticonvulsants; Benzyl Compounds; Chi-Square Distribution; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Reaction Time; Seizures; Sodium-Calcium Exchanger; Thiazolidines; Thiourea | 2013 |
Anti-inflammatory, anti-bacterial activity and structure-activity relationships of substitutions on 4-thiazolidinone derivatives - Part-1.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Disease Models, Animal; Disk Diffusion Antimicrobial Tests; Formaldehyde; Inflammation; Male; Mice; Molecular Structure; Structure-Activity Relationship; Thiazolidines; Time Factors | 2012 |
Molecular cloning and characterization of Schistosoma japonicum aldose reductase.
Topics: Aldehyde Reductase; Amino Acid Sequence; Animals; Antigens, Helminth; Blotting, Western; Cloning, Molecular; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Profiling; Male; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; Rhodanine; Schistosoma japonicum; Schistosomiasis japonica; Thiazolidines; Vaccination; Vaccines, Synthetic | 2013 |
A diet supplemented with thiolic anti-oxidants improves leucocyte function in two strains of prematurely ageing mice.
Topics: Acetylcysteine; Aging, Premature; Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Female; Leukocytes; Mice; Mice, Inbred BALB C; Species Specificity; Sulfhydryl Compounds; Thiazoles; Thiazolidines | 2002 |
An inhibitor of advanced glycation end product formation reduces N epsilon-(carboxymethyl)lysine accumulation in glomeruli of diabetic rats.
Topics: Age Factors; Animals; Antibodies, Monoclonal; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Fluorescent Antibody Technique, Indirect; Glomerular Mesangium; Glycation End Products, Advanced; Kidney; Kidney Glomerulus; Lysine; Rats; Rats, Inbred OLETF; Rats, Inbred Strains; Thiadiazoles; Thiazolidines | 2003 |
Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Blotting, Western; Brain; Cell Count; Cell Death; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; MPTP Poisoning; PC12 Cells; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Cell Adhesion Molecules; Chemokines; Disease Models, Animal; Eosinophil Cationic Protein; Interleukins; Lung; Mice; NF-kappa B; Ovalbumin; Prodrugs; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2004 |
[Characterization of SN-6, a novel exchange inhibitor and its renal protective effect].
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Benzyl Compounds; Calcium; Cells, Cultured; Cricetinae; Depression, Chemical; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Ischemia; Kidney Tubules; LLC-PK1 Cells; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sodium-Calcium Exchanger; Swine; Thiazoles; Thiazolidines | 2004 |
Effect of novel arecoline thiazolidinones as muscarinic receptor 1 agonist in Alzheimer's dementia models.
Topics: Acetylcholine; Alzheimer Disease; Animals; Arecoline; Binding, Competitive; Brain; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Male; Maze Learning; Memory; Memory Disorders; Molecular Structure; Muscarinic Agonists; Radioligand Assay; Rats; Rats, Wistar; Receptor, Muscarinic M1; Thiazolidines | 2008 |
Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats.
Topics: Alcoholism; Animals; Antioxidants; Biomarkers; Central Nervous System Depressants; Disease Models, Animal; Disease Progression; Ethanol; Glutathione; Male; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Muscular Diseases; Oxidants; Oxidation-Reduction; Oxidative Stress; Pyrrolidonecarboxylic Acid; Rats; Rats, Sprague-Dawley; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Thiazolidines; Transforming Growth Factor beta1; Up-Regulation | 2007 |
Ingestion of thioproline suppresses rat esophageal adenocarcinogenesis caused by duodenogastroesophageal reflux.
Topics: Adenocarcinoma; Administration, Oral; Animals; Disease Models, Animal; Duodenum; Esophageal Neoplasms; Gastroesophageal Reflux; Male; Rats; Rats, Inbred F344; Thiazolidines | 2007 |
Rectal potential difference and the functional expression of CFTR in the gastrointestinal epithelia in cystic fibrosis mouse models.
Topics: Animals; Benzoates; Colforsin; Colon; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Disease Models, Animal; Genotype; Intestinal Mucosa; Membrane Potentials; Mice; Mice, Inbred CFTR; Mice, Mutant Strains; Phenotype; Rectum; Reproducibility of Results; Thiazolidines | 2008 |
Effects of dipeptidyl peptidase iv inhibition on arterial blood pressure.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arginine; Blood Pressure; Captopril; Chlorisondamine; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Ganglionic Blockers; Hydralazine; Hypertension; Pentanoic Acids; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Neuropeptide Y; Thiazolidines; Vasodilator Agents | 2008 |
Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.
Topics: Acetylcholine; Animals; Animals, Genetically Modified; Antioxidants; Aorta; Biopterins; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelium, Vascular; Glutathione; HIV Infections; HIV-1; Human Immunodeficiency Virus Proteins; Male; NADPH Oxidases; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Proviruses; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred F344; Superoxides; Thiazolidines; Tyrosine; Vasodilation; Vasodilator Agents; Xanthine Oxidase | 2008 |
[Hydroelactic and ecbolic of piprozoline on basal bile-pancreatic secretion in rats].
Topics: Animals; Bile; Bile Acids and Salts; Biliary Fistula; Bilirubin; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Pancreas; Pancreatic Fistula; Rats; Secretin; Thiazoles; Thiazolidines | 1984 |
MK-771 antagonizes the enhanced response to apomorphine in rats treated chronically with haloperidol - implications for tardive dyskinesia.
Topics: Animals; Apomorphine; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Haloperidol; Humans; Rats; Rats, Inbred Strains; Receptors, Dopamine; Stereotyped Behavior; Thiazolidines; Thyrotropin-Releasing Hormone | 1982 |
Effect of YM264 on the airway hyperresponsiveness and the late asthmatic response in a guinea pig model of asthma.
Topics: Aerosols; Airway Resistance; Analysis of Variance; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Guinea Pigs; Immunization; Male; Ovalbumin; Piperazines; Platelet Activating Factor; Random Allocation; Statistics, Nonparametric; Thiazoles; Thiazolidines; Time Factors; Trachea | 1995 |
Increased endogenous N-nitrosamine and nitrate formation by induction of nitric oxide synthase in rats with acute hepatic injury caused by Propionibacterium acnes and lipopolysaccharide administration.
Topics: Amino Acid Oxidoreductases; Animals; Disease Models, Animal; Enzyme Induction; Lipopolysaccharides; Liver Diseases; Male; Necrosis; Nitrates; Nitric Oxide Synthase; Nitrosamines; Nitroso Compounds; Propionibacterium acnes; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1993 |
Thiaproline reduces glomerular basement membrane thickness and collagen accumulation in the db/db mouse.
Topics: Animals; Antioxidants; Basement Membrane; Blood Glucose; Collagen; Diabetic Nephropathies; Disease Models, Animal; Female; Fructosamine; Hexosamines; Kidney; Kidney Glomerulus; Mice; Mice, Inbred Strains; Organ Size; Solubility; Thiazoles; Thiazolidines | 1994 |
Antithrombotic effects of MK-0852, a platelet fibrinogen receptor antagonist, in canine models of thrombosis.
Topics: Amino Acid Sequence; Animals; Bleeding Time; Blood Platelets; Coronary Circulation; Coronary Thrombosis; Disease Models, Animal; Dogs; Female; Femoral Artery; Fibrinolytic Agents; Kinetics; Male; Molecular Sequence Data; Oligopeptides; Peptides, Cyclic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Membrane Glycoproteins; Thiazolidines; Thrombosis | 1993 |
Effects of moguisteine, a peripheral nonnarcotic antitussive agent, on airway inflammation in guinea-pigs in vivo.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents; Antitussive Agents; Bronchial Hyperreactivity; Capsaicin; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Inflammation; Male; Regression Analysis; Respiratory System; Smoke; Thiazoles; Thiazolidines | 1996 |
A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats.
Topics: Animals; Blood Coagulation; Disease Models, Animal; Disseminated Intravascular Coagulation; Endotoxins; Female; Humans; Infant, Newborn; Platelet Activating Factor; Pulmonary Artery; Rats; Rats, Wistar; Respiratory Distress Syndrome, Newborn; Thiazoles; Thiazolidines | 1996 |
Role of plasma insulin concentration in regulating glucose and lipid metabolism in lean and obese Zucker rats.
Topics: Administration, Oral; Animals; Blood Glucose; Cholesterol; Cholesterol, HDL; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Hypoglycemic Agents; Insulin; Lipid Metabolism; Lipids; Male; Mice; Mice, Inbred Strains; Obesity; Rats; Rats, Zucker; Thiazoles; Thiazolidines; Time Factors; Triglycerides | 1997 |
Progression of nephropathy in spontaneous diabetic rats is prevented by OPB-9195, a novel inhibitor of advanced glycation.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Glomerulosclerosis, Focal Segmental; Glycation End Products, Advanced; Male; Rats; Rats, Inbred Strains; Thiadiazoles; Thiazolidines | 1997 |
The effect of (L)-cysteine and (L)-2-oxothiazolidine-4-carboxylic acid (OTZ) on urinary oxalate excretion: studies using a hyperoxaluric rat model.
Topics: Animals; Cysteine; Disease Models, Animal; Male; Oxalates; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Urinary Calculi | 1998 |
Antitussive effect of moguisteine on allergic coughs in the guinea pig.
Topics: Analgesics, Opioid; Animals; Antitussive Agents; Codeine; Cough; Disease Models, Animal; Guinea Pigs; Hypersensitivity; Male; Thiazoles; Thiazolidines | 1998 |
Protective effects of a PAF receptor antagonist and a neutrophil elastase inhibitor on multiple organ failure induced by cerulein plus lipopolysaccharide in rats.
Topics: Alanine Transaminase; Amylases; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Ceruletide; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kidney; Leukocyte Elastase; Lipase; Lipopolysaccharides; Liver; Lung; Male; Multiple Organ Failure; Organ Size; Pancreas; Pancreatitis; Piperazines; Platelet Membrane Glycoproteins; Pyridones; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sulfonamides; Survival Rate; Thiazoles; Thiazolidines; Time Factors | 1998 |
Possible role of platelet-activating factor in the in vivo expression of tissue factor in neutrophils.
Topics: Animals; Aspartate Aminotransferases; Blood Coagulation; Cholangitis; Disease Models, Animal; Leukocytes; Liver; Male; Neutrophils; Platelet Activating Factor; Rabbits; Thiazoles; Thiazolidines; Thromboplastin | 1998 |
Involvement of ATP-sensitive K(+) channels in the anti-tussive effect of moguisteine.
Topics: Animals; Antitussive Agents; ATP-Binding Cassette Transporters; Cough; Disease Models, Animal; Drug Interactions; Glyburide; Guinea Pigs; KATP Channels; Male; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Thiazoles; Thiazolidines | 2000 |
Platelet GPIIb/IIIa receptor blockade reduces infarct size in a canine model of ischemia-reperfusion.
Topics: Animals; Coronary Circulation; Disease Models, Animal; Dogs; Female; Flow Cytometry; Heart; Hemodynamics; Hyperemia; Male; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Oligopeptides; Peptides, Cyclic; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Thiazolidines | 2000 |
Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice.
Topics: Animals; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Disease Models, Animal; Female; Gene Expression Regulation; Glomerular Mesangium; Glycation End Products, Advanced; Kidney; Male; Mice; Mice, Transgenic; Muscle, Smooth, Vascular; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiadiazoles; Thiazolidines | 2001 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Male; Ovalbumin; Platelet Activating Factor; Propranolol; Pyrilamine; SRS-A; Thiazoles; Thiazolidines | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 2. Effect on antigen-induced dual asthmatic response and infiltration of leukocytes into airways in actively sensitized conscious guinea pigs.
Topics: Animals; Antigens; Asthma; Cromolyn Sodium; Disease Models, Animal; Fenoterol; Guinea Pigs; Leukocytes; Lung; Male; Ovalbumin; Platelet Activating Factor; Respiratory Function Tests; Respiratory System; Thiazoles; Thiazolidines | 1991 |
Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat.
Topics: Animals; Azepines; Disease Models, Animal; Glomerulonephritis, Membranous; Hypercholesterolemia; Male; Metabolic Clearance Rate; Methylprednisolone; Piperazines; Platelet Activating Factor; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Ticlopidine; Triazoles | 1991 |
[Preparation of cerebral ischemia-induced amnesic model in mice and ameliorative effect of several compounds on the model].
Topics: Amnesia; Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mice; Mice, Inbred ICR; Pyrrolidinones; Thiazoles; Thiazolidines | 1989 |
Short-term primary culture of rat prostate tumor epithelial cells on reconstituted basement membrane as a useful in vitro model to assess drug action on prostatic cancer: efficacy of the thiazolidinedione derivative CGP 19984.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Basement Membrane; Disease Models, Animal; Epithelium; Male; Prostatic Neoplasms; Rats; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1989 |
Preliminary studies on the effects of a TRH analog, MK-771, in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antidepressive Agents; Disease Models, Animal; Rats; Thiazolidines; Thyrotropin-Releasing Hormone | 1987 |