thiazolidines has been researched along with Alloxan Diabetes in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (15.69) | 18.7374 |
| 1990's | 16 (31.37) | 18.2507 |
| 2000's | 12 (23.53) | 29.6817 |
| 2010's | 13 (25.49) | 24.3611 |
| 2020's | 2 (3.92) | 2.80 |
| Authors | Studies |
|---|---|
| Asati, V; Baweja, GS; Gupta, S; Irani, M; Singh, R; Singh, S | 1 |
| Choudhary, S; Kumar, M; Silakari, O | 1 |
| Jaiswal, S; Mishra, S; Shengule, S; Torgal, SS | 1 |
| Chen, GT; Chen, Y; Dai, YT; Hong, ZW; Jiang, HS; Song, T; Yang, BB; Yu, W; Zhang, Z; Zhu, LL | 1 |
| Bhutani, R; Husain, A; Iqbal, MA; Kapoor, G; Pathak, DP | 1 |
| Anton, A; Caruntu, ID; Giusca, SE; Lupascu, FG; Lupușoru, CE; Profire, L | 1 |
| Cheng, F; Cheng, X; Hu, Y; Rao, J; Shen, G; Wang, X; Yang, C; Yang, S | 1 |
| Kanasaki, K; Katoh, M; Kitada, M; Koya, D; Shi, S; Takagaki, Y | 1 |
| Alarcón-Aguilar, FJ; Almanza-Pérez, JC; Estrada-Soto, S; Hidalgo-Figueroa, S; León-Rivera, I; Medina-Franco, JL; Navarrete-Vázquez, G; Ramírez-Espinosa, JJ; Torres-Gómez, H | 1 |
| Amizuka, N; Fujie, A; Hao, W; Hasegawa, T; Katsuyama, E; Kobayashi, T; Matsumoto, M; Miyamoto, K; Miyamoto, T; Morioka, H; Morita, M; Nakamura, M; Sato, Y; Tando, T; Tashiro, S; Toyama, Y; Watanabe, R | 1 |
| Feng, Z; Kusunoki, M; Nakamura, T; Nishina, A; Sato, D; Shinzawa, G | 1 |
| Ide, M; Inoguchi, T; Kimura, S; Sonoda, N; Takayanagi, R; Yamada, K; Yamasaki, T; Yamato, M | 1 |
| Huan, Y; Ji, LX; Li, CN; Liu, Q; Shen, N; Shen, ZF | 1 |
| Handa, O; Hirai, M; Hirata, I; Naito, Y; Okada, H; Oya-Ito, T; Suzuki, T; Takagi, T; Uchida, K; Uchiyama, K; Yoshikawa, T | 1 |
| Chai, Q; Li, J; Li, JY; Li, YY; Liu, Z; Ma, LP; Shen, JK; Shen, Q; Sheng, L; Wang, X; Zhang, LN | 1 |
| Breschi, MC; Calderone, V; Da Settimo, F; La Motta, C; Martelli, A; Sartini, S; Testai, L | 1 |
| Alarcón-Aguilar, FJ; Almanza-Pérez, JC; Díaz-Coutiño, D; Estrada-Soto, S; Hernández-Rosado, JV; Hidalgo-Figueroa, S; Moreno-Díaz, H; Navarrete-Vázquez, G; Ramírez-Espinosa, JJ; Román-Ramos, R | 1 |
| Fujimoto, S; Fukuda, K; Hosokawa, M; Nagashima, K; Nakamura, H; Oya, M; Seino, Y; Tsukada, H; Tsukiyama, K; Yamada, Y | 1 |
| Kim, BK; Lee, S; Lee, YS; Shin, KH | 1 |
| Arch, JR; Augstein, P; Cawthorne, MA; Demuth, HU; Heinke, P; Hoffmann, T; Meyer, A; Sennitt, MV; Stocker, C; Subramanian, A; Wargent, E | 1 |
| Fujiwara, H; Kajiyama, S; Kanegawa, N; Kiyono, Y; Saji, H | 1 |
| Izuhara, Y; Miyata, T; Yamamoto, M | 1 |
| Inoue, M; Ishida, S; Izumi-Nagai, K; Koto, T; Nagai, N; Oike, Y; Ozawa, Y; Satofuka, S; Tsubota, K; Umezawa, K; Yamashiro, K | 1 |
| Cheng, JT; Tong, YC | 1 |
| Hatanaka, I; Kikkawa, R; Kobayashi, N; Morimura, T; Shigeta, Y; Terashima, H; Tsuboshima, M; Yasuda, H | 1 |
| Hatanaka, I; Kikkawa, R; Kobayashi, N; Shigeta, Y; Yasuda, H | 1 |
| Ewen, SW; Helgason, T; Jaffray, B; Outram, JR; Pollock, JR; Stowers, JM | 1 |
| Ebata, K; Haneda, M; Itagaki, I; Kamanaka, Y; Kikkawa, R; Shigeta, Y; Shimizu, K | 1 |
| Booth, RJ; Hodgson, WC | 1 |
| Inokuchi, T; Isogai, S; Ohe, K | 1 |
| Eto, K; Hashimoto, K; Kanda, M; Sugiyama, A; Tanabe, N; Ueno, A | 1 |
| Furuta, M; Kishi, Y; Mukoyama, M; Naka, K; Nanjo, K; Sanke, T; Sasaki, H | 1 |
| Kurata, C; Mikami, T; Okayama, K; Shouda, S; Sugiyama, T; Tawarahara, K; Wakabayashi, Y | 1 |
| Kashima, K; Mori, M; Sato, K; Sato, N; Shimizu, H | 1 |
| Ohara, S; Shimosegawa, T; Suzuki, H; Toyota, T | 1 |
| Miura, S | 1 |
| Horie, H; Inoue, S; Sango, K | 1 |
| Aoki, T; Makino, M; Mizuno, K; Sassa, H; Sobajima, H; Suzuki, T; Taniko, K | 1 |
| Ishikawa, Y; Nakano, M; Nishizawa, Y; Takeuchi, M; Wada, R; Yagihashi, N; Yagihashi, S; Yasumura, K | 1 |
| Cheng, JT; Chin, WT; Tong, YC | 1 |
| Aida, K; Onaya, T; Shindo, H; Tawata, M | 1 |
| Nakashima, M; Takiguchi, Y; Wada, K | 1 |
| Inoue, M; Noguchi, T; Onaya, T; Shindo, H; Tawata, M; Wakasugi, M | 1 |
| Eto, M; Ishii, K; Iwashima, Y; Makino, I; Morikawa, A; Sekiguchi, M; Takahashi, M; Watanabe, K | 1 |
| Hashimoto, H; Nakashima, M; Sato, N; Takiguchi, Y | 1 |
| Hashimoto, H; Nakashima, M; Satoh, N; Takiguchi, Y | 1 |
| Homma, S; Ito, S; Karakida, T | 1 |
| Hatanaka, I; Huitian, Z; Shigeta, Y; Sonobe, M; Terada, M; Yamashita, M; Yasuda, H | 1 |
| Kondo, M; Nakano, K; Nishioka, H; Terashima, H; Yoshida, T; Yoshioka, K | 1 |
| Harada, T; Hotta, N; Kakuta, H; Kojima, K; Matsubara, H; Mizuno, K; Sakamoto, N; Suzuki, M | 1 |
| Fukasawa, H; Hotta, N; Iida, M; Kakuta, H; Kimura, M; Koh, N; Morimura, T; Sakamoto, N; Terashima, H | 1 |
51 other study(ies) available for thiazolidines and Alloxan Diabetes
| Article | Year |
|---|---|
Integrated fragment-based drug design and virtual screening techniques for exploring the antidiabetic potential of thiazolidine-2,4-diones: Design, synthesis and in vivo studies.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Design; Hypoglycemic Agents; Mice; Molecular Docking Simulation; Pioglitazone; PPAR gamma; Thiazolidinediones; Thiazolidines; Zebrafish | 2023 |
QM/MM analysis, synthesis and biological evaluation of epalrestat based mutual-prodrugs for diabetic neuropathy and nephropathy.
Topics: Animals; Density Functional Theory; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Hypoglycemic Agents; Male; Molecular Structure; Prodrugs; Rats; Rats, Wistar; Rhodanine; Streptozocin; Structure-Activity Relationship; Thiazolidines | 2021 |
Neuroprotective effect of epalrestat mediated through oxidative stress markers, cytokines and TAU protein levels in diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Cognition Disorders; Cytokines; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet, High-Fat; Hippocampus; Inflammation; Male; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Rhodanine; tau Proteins; Thiazolidines | 2018 |
Epalrestat, an Aldose Reductase Inhibitor, Restores Erectile Function in Streptozocin-induced Diabetic Rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Erectile Dysfunction; Male; Muscle, Smooth; Myocytes, Smooth Muscle; Nerve Growth Factor; Nitric Oxide Synthase Type I; Penile Erection; Penis; Rats; Rats, Sprague-Dawley; Rhodanine; Streptozocin; Thiazolidines | 2019 |
Novel hybrids of benzothiazole-1,3,4-oxadiazole-4-thiazolidinone: Synthesis, in silico ADME study, molecular docking and in vivo anti-diabetic assessment.
Topics: Administration, Oral; Animals; Benzothiazoles; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Glucose Tolerance Test; Hypoglycemic Agents; Male; Molecular Docking Simulation; Molecular Structure; Oxadiazoles; Rats; Rats, Wistar; Streptozocin; Structure-Activity Relationship; Thiazolidines | 2019 |
The safety profile of new antidiabetic xanthine derivatives and their chitosan based formulations.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Hematologic Tests; Hypoglycemic Agents; Kidney; Lipid Metabolism; Liver; Rats; Thiazolidines; Xanthines | 2019 |
Hyperglycemia-Triggered Sphingosine-1-Phosphate and Sphingosine-1-Phosphate Receptor 3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization.
Topics: Aged; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Humans; Hyperglycemia; Liver; Liver Diseases; Liver Transplantation; Lysophospholipids; Macrophages; Male; Mice; Middle Aged; Reperfusion Injury; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Streptozocin; Thiazolidines | 2019 |
Dipeptidyl peptidase-4 plays a pathogenic role in BSA-induced kidney injury in diabetic mice.
Topics: Animals; Caveolin 1; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Epithelial-Mesenchymal Transition; Fibrosis; Humans; Integrin beta1; Kidney Tubules; Male; Mice; Pyrazoles; Serum Albumin, Bovine; Signal Transduction; Smad3 Protein; Thiazolidines; Transforming Growth Factor beta | 2019 |
Synthesis, in vitro and in silico studies of a PPARγ and GLUT-4 modulator with hypoglycemic effect.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Ligands; Mice; Molecular Docking Simulation; Molecular Structure; PPAR gamma; Rats; RNA, Messenger; Thiazolidines | 2014 |
Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation.
Topics: Aldehyde Reductase; Animals; Calcitriol; Cell Dedifferentiation; Cells, Cultured; Demyelinating Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Down-Regulation; Enzyme Inhibitors; Glucose; Hyperglycemia; In Vitro Techniques; Insulin-Like Growth Factor I; Mice; Mice, Inbred C57BL; Models, Neurological; Rats; Rhodanine; Schwann Cells; Sciatic Nerve; Sorbitol; Thiazolidines; Vitamin D | 2015 |
Effects of aldose reductase inhibitor on microneurographically assessed peripheral sympathetic nerve activity in rats.
Topics: Action Potentials; Aldehyde Reductase; Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Heart Rate; Insulin; Male; Neuroprotective Agents; Rats, Wistar; Rhodanine; Sciatic Nerve; Sympathetic Nervous System; Thiazolidines | 2015 |
A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats.
Topics: Animals; Blood Glucose; Chromatography, Thin Layer; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Hydroxyl Radical; Pyrazoles; Rats; Rats, Inbred F344; Reactive Oxygen Species; Thiazolidines | 2016 |
[Inhibition effect of epalrestat on rat lens osmotic expansion].
Topics: Aldehyde Reductase; Animals; Aquaporin 1; Cataract; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Galactose; Lens, Crystalline; Male; Osmosis; Rats; Rats, Sprague-Dawley; Rhodanine; RNA, Messenger; Thiazolidines | 2009 |
Impaired gastric ulcer healing in diabetic mice: role of methylglyoxal.
Topics: Animals; Anti-Ulcer Agents; Blood Glucose; Diabetes Mellitus, Experimental; Gastric Mucosa; Glycation End Products, Advanced; Glycosylation; Male; Mice; Mice, Inbred C57BL; Ornithine; Peroxiredoxin VI; Protein Processing, Post-Translational; Proteins; Pyrimidines; Pyruvaldehyde; Regeneration; Severity of Illness Index; Stomach Ulcer; Thiadiazoles; Thiazolidines; Wound Healing | 2009 |
Discovery of novel PTP1B inhibitors with antihyperglycemic activity.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Design; Enzyme Inhibitors; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Thiazolidines | 2010 |
Anti-ischaemic activity of an antioxidant aldose reductase inhibitor on diabetic and non-diabetic rat hearts.
Topics: Aldehyde Reductase; Animals; Antioxidants; Cardiotonic Agents; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme Inhibitors; Male; Myocardial Reperfusion Injury; Myocardium; Pyridines; Pyrimidinones; Rats; Rats, Wistar; Rhodanine; Thiazolidines | 2010 |
Discovery of thiazolidine-2,4-dione/biphenylcarbonitrile hybrid as dual PPAR α/γ modulator with antidiabetic effect: in vitro, in silico and in vivo approaches.
Topics: 3T3-L1 Cells; Animals; Barbiturates; Binding Sites; Blood Glucose; Catalytic Domain; Diabetes Mellitus, Experimental; Drug Evaluation, Preclinical; Glucose Transporter Type 4; Humans; Hydrogen Bonding; Hypoglycemic Agents; Male; Mice; Molecular Docking Simulation; Nitriles; PPAR alpha; PPAR gamma; Rats; Rats, Wistar; RNA, Messenger; Thiazolidinediones; Thiazolidines; Transcription, Genetic | 2013 |
Effects of an aldose reductase inhibitor on gastroenteropathy in streptozotocin-diabetic rats.
Topics: Acetaminophen; Aldehyde Reductase; Animals; Blood Glucose; Body Water; Colon; Diabetes Mellitus, Experimental; Electrolytes; Enzyme Inhibitors; Feces; Gastric Emptying; Intestinal Mucosa; Male; Rats; Rats, Wistar; Rhodanine; Tetrodotoxin; Thiazolidines; Time Factors | 2003 |
Anti-diabetic activities of fucosterol from Pelvetia siliquosa.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Liver; Liver Glycogen; Male; Mice; Phaeophyceae; Rats; Rats, Sprague-Dawley; Rhodanine; Stigmasterol; Thiazolidines | 2004 |
Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Drinking; Drug Therapy, Combination; Drug Tolerance; Eating; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Obesity; Pentanoic Acids; Rats; Rats, Zucker; Rosiglitazone; Thiazoles; Thiazolidinediones; Thiazolidines; Time Factors | 2005 |
Influence of the polyol pathway on norepinephrine transporter reduction in diabetic cardiac sympathetic nerves: implications for heterogeneous accumulation of MIBG.
Topics: 3-Iodobenzylguanidine; Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Heart; Male; Metabolic Clearance Rate; Myocardium; Norepinephrine Plasma Membrane Transport Proteins; Polymers; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Rhodanine; Signal Transduction; Sorbitol; Streptozocin; Sympathetic Nervous System; Symporters; Thiazolidines | 2005 |
From molecular footprints of disease to new therapeutic interventions in diabetic nephropathy.
Topics: Animals; Antioxidants; Biomarkers; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycation End Products, Advanced; Guanidines; Humans; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thiadiazoles; Thiazolidines | 2005 |
Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Benzamides; Blotting, Western; Cell Adhesion; Chemokine CCL2; Cyclohexanones; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Enzyme-Linked Immunosorbent Assay; Imidazoles; Intercellular Adhesion Molecule-1; Leukocytes; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Pyridines; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Retinitis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazoles; Thiazolidines; Valine; Valsartan; Vascular Endothelial Growth Factor A | 2007 |
Aldose reductase inhibitor ONO-2235 restores the alterations of bladder nerve growth factor and neurotrophin receptor p75 genetic expression in streptozotocin induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Antibiotics, Antineoplastic; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression; Male; Nerve Growth Factor; Rats; Rats, Wistar; Receptor, Nerve Growth Factor; Reverse Transcriptase Polymerase Chain Reaction; Rhodanine; RNA, Messenger; Streptozocin; Thiazolidines; Urinary Bladder; Urodynamics | 2007 |
Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235) on peripheral nerve disorders in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Erythrocytes; Insulin; Male; Neural Conduction; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Thiazoles; Thiazolidines | 1983 |
Prevention of peripheral nerve dysfunction by an aldose reductase inhibitor in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Male; Motor Neurons; Neural Conduction; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Thiazoles; Thiazolidines | 1984 |
N-nitrosamines in smoked meats and their relation to diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diet; Dimethylnitrosamine; Food Preservation; Meat; Mice; Nitrosamines; Nitroso Compounds; Thiazoles; Thiazolidines | 1984 |
The effect of an aldose reductase inhibitor (Epalrestat) on diabetic nephropathy in rats.
Topics: Albuminuria; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme-Linked Immunosorbent Assay; Glomerular Filtration Rate; Glomerular Mesangium; Kidney; Male; Organ Size; Rats; Rats, Sprague-Dawley; Renal Circulation; Rhodanine; Thiazolidines | 1994 |
Effects of aldose reductase inhibition with epalrestat on diabetes-induced changes in rat isolated atria.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Heart Atria; Heart Rate; In Vitro Techniques; Insulin; Isoproterenol; Male; Myocardial Contraction; Myocardium; Organ Size; Rats; Rats, Wistar; Rhodanine; Thiazolidines | 1993 |
Effect of an aldose reductase inhibitor on glomerular basement membrane anionic sites in streptozotocin-induced diabetic rats.
Topics: Administration, Oral; Albuminuria; Aldehyde Reductase; Animals; Anions; Basement Membrane; Blood Glucose; Blood Pressure; Cohort Studies; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Enzyme Inhibitors; Erythrocytes; Kidney Glomerulus; Male; Rats; Rats, Wistar; Rhodanine; Sorbitol; Thiazolidines; Time Factors | 1995 |
Effects of ONO-2235, an aldose reductase inhibitor, on muscarinic receptors and contractile response of the urinary bladder in rats with streptozotocin-induced diabetes.
Topics: Acetylcholine; Aldehyde Reductase; Analysis of Variance; Animals; Binding, Competitive; Blood Glucose; Diabetes Mellitus, Experimental; Diuresis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperglycemia; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Receptors, Muscarinic; Rhodanine; Sciatic Nerve; Sorbitol; Thiazolidines; Tissue Preservation; Urinary Bladder | 1997 |
The absence of synergism between the effects of an aldose reductase inhibitor, epalrestat, and a vasodilator, cilostazol, on the nerve conduction slowing and the myelinated fiber atrophy in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Atrophy; Cilostazol; Diabetes Mellitus, Experimental; Drug Synergism; Enzyme Inhibitors; Male; Nerve Fibers, Myelinated; Neural Conduction; Rats; Rats, Wistar; Rhodanine; Tetrazoles; Thiazolidines; Time Factors; Vasodilator Agents | 1997 |
Cardiac sympathetic neuropathy and effects of aldose reductase inhibitor in streptozotocin-induced diabetic rats.
Topics: 3-Iodobenzylguanidine; Aldehyde Reductase; Animals; Autonomic Nervous System Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Enzyme Inhibitors; Heart; Insulin; Iodine Radioisotopes; Male; Myocardium; Norepinephrine; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rhodanine; Thiazolidines | 1997 |
Effect of epalrestat, an aldose reductase inhibitor, on the generation of oxygen-derived free radicals in neutrophils from streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Luminescent Measurements; Luminol; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pyrazines; Rats; Rats, Wistar; Reactive Oxygen Species; Rhodanine; Superoxides; Thiazolidines | 1998 |
Epalrestat prevents the decrease in gastric mucosal blood flow and protects the gastric mucosa in streptozotocin diabetic rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gastric Mucosa; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Rhodanine; Thiazolidines | 1999 |
Decreased gastric mucosal barrier function in diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Gastric Mucosa; Humans; Microcirculation; Rabbits; Rats; Rhodanine; Thiazolidines | 1999 |
Administration of an aldose reductase inhibitor, ONO-2235, to streptozotocin-diabetic mice restores reductions of DRG neuronal attachment to extracellular matrix proteins in vitro.
Topics: Aldehyde Reductase; Amino Acid Sequence; Animals; Cell Adhesion; Cells, Cultured; Collagen; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Extracellular Matrix Proteins; Female; Fibronectins; Ganglia, Spinal; Laminin; Mice; Mice, Inbred C57BL; Neurons; Oligopeptides; Reference Values; Rhodanine; Thiazolidines | 1999 |
Pharmacological properties of fidarestat, a potent aldose reductase inhibitor, clarified by using sorbitol in human and rat erythrocytes.
Topics: Age Factors; Aldehyde Reductase; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Fasting; Female; Glycated Hemoglobin; Humans; Imidazoles; Imidazolidines; Male; Rats; Rats, Sprague-Dawley; Rhodanine; Sciatic Nerve; Sex Factors; Sorbitol; Thiazolidines | 2001 |
Effects of OPB-9195, anti-glycation agent, on experimental diabetic neuropathy.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Glycation End Products, Advanced; Male; Nerve Degeneration; Neural Conduction; Rats; Rats, Wistar; Thiadiazoles; Thiazolidines | 2001 |
Role of sorbitol in the up-regulation of urinary bladder M(2) muscarinic receptors in streptozotocin-induced diabetic rats.
Topics: Aldehyde Reductase; Animals; Autoradiography; Blotting, Northern; Blotting, Western; Diabetes Mellitus, Experimental; Diuretics, Osmotic; Glucose; Male; Rats; Rats, Wistar; Receptor, Muscarinic M2; Receptors, Muscarinic; Reference Values; Rhodanine; RNA, Messenger; Sorbitol; Thiazolidines; Up-Regulation; Urinary Bladder | 2002 |
The role of cyclic adenosine 3',5'-monophosphate and polyol metabolism in diabetic neuropathy.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Chalcone; Chalcones; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Iloprost; Inositol; Male; Neural Conduction; Rats; Rats, Inbred WKY; Rhodanine; Sciatic Nerve; Sorbitol; Thiazolidines | 1992 |
Effect of aldose reductase inhibitor on the inhibition of platelet aggregation induced by diabetic rat plasma.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Erythrocytes; In Vitro Techniques; Insulin; Male; Platelet Aggregation; Rats; Rats, Wistar; Rhodanine; Sorbitol; Thiazolidines | 1992 |
Effects of aldose reductase inhibitors on prostacyclin (PGI2) synthesis by aortic rings from rats with streptozotocin-induced diabetes.
Topics: Aldehyde Reductase; Animals; Aorta, Thoracic; Blood Glucose; Chalcone; Chalcones; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Epoprostenol; Male; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Streptozocin; Sugar Alcohols; Thiazolidines | 1991 |
Polyol pathway in tissues of spontaneously diabetic Chinese hamsters (Cricetulus griseus) and the effect of an aldose reductase inhibitor, ONO-2235.
Topics: Aldehyde Reductase; Animals; Cricetinae; Cricetulus; Diabetes Mellitus, Experimental; Female; Fructose; Inositol; Kidney; Lens, Crystalline; Male; Polymers; Retina; Rhodanine; Sciatic Nerve; Sorbitol; Thiazolidines | 1991 |
Effect of an aldose reductase inhibitor on altered sympathetic nerve responsiveness of isolated right atria in diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Chemical Analysis; Body Weight; Diabetes Mellitus, Experimental; Electric Stimulation; Heart; Heart Diseases; Heart Rate; Insulin; Male; Norepinephrine; Rats; Rats, Inbred Strains; Rhodanine; Sympathetic Nervous System; Thiazolidines | 1990 |
Effects of an aldose reductase inhibitor, ONO-2235, insulin and their combination on the altered responsiveness to the nerve stimulation and agonists of the isolated atria of diabetic rats.
Topics: Aldehyde Reductase; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Electric Stimulation; Heart Atria; In Vitro Techniques; Insulin; Male; Muscle, Smooth; Myocardial Contraction; Norepinephrine; Rats; Rats, Inbred Strains; Rhodanine; Sugar Alcohol Dehydrogenases; Synaptic Transmission; Thiazoles; Thiazolidines | 1990 |
In vitro motor activity of intestinal segments of streptozotocin diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; In Vitro Techniques; Insulin; Intestines; Male; Muscle Contraction; Rats; Rats, Inbred Strains; Rhodanine; Streptozocin; Thiazolidines | 1989 |
Effect of prostaglandin E1 analogue TFC 612 on diabetic neuropathy in streptozocin-induced diabetic rats. Comparison with aldose reductase inhibitor ONO 2235.
Topics: Adenosine Triphosphate; Aldehyde Reductase; Alprostadil; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Electrophysiology; Inositol; Lactates; Male; Myelin Sheath; Nerve Fibers; Phosphocreatine; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Streptozocin; Sugar Alcohol Dehydrogenases; Thiazoles; Thiazolidines | 1989 |
Effect of aldose reductase inhibitor ONO 2235 on reduced sympathetic nervous system activity and peripheral nerve disorders in STZ-induced diabetic rats.
Topics: Aldehyde Reductase; alpha-Methyltyrosine; Animals; Autonomic Nervous System Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Erythrocytes; Female; Methyltyrosines; Neural Conduction; Norepinephrine; Peripheral Nervous System Diseases; Rats; Rats, Inbred Strains; Rhodanine; Sciatic Nerve; Sorbitol; Streptozocin; Sugar Alcohol Dehydrogenases; Sympathetic Nervous System; Thiazoles; Thiazolidines; Triiodothyronine | 1987 |
Effects of aldose reductase inhibitor on retinal microangiopathy in streptozotocin-diabetic rats.
Topics: Aldehyde Reductase; Animals; Basement Membrane; Blood Glucose; Body Weight; Capillaries; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; Retinal Vessels; Rhodanine; Streptozocin; Sugar Alcohol Dehydrogenases; Thiazoles; Thiazolidines | 1985 |
Effects of a fructose-rich diet and the aldose reductase inhibitor, ONO-2235, on the development of diabetic neuropathy in streptozotocin-treated rats.
Topics: Aldehyde Reductase; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dietary Carbohydrates; Erythrocytes; Fructose; Male; Motor Neurons; Neural Conduction; Rats; Retina; Rhodanine; Sciatic Nerve; Sorbitol; Sugar Alcohol Dehydrogenases; Thiazoles; Thiazolidines | 1985 |