thiazoles has been researched along with Multiple Sclerosis in 50 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.00) | 18.2507 |
| 2000's | 7 (14.00) | 29.6817 |
| 2010's | 20 (40.00) | 24.3611 |
| 2020's | 22 (44.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chisari, CG; Finocchiaro, C; Lo Fermo, S; Millefiorini, E; Patti, F; Sgarlata, E; Toscano, S | 1 |
| Ianniello, A; Pozzilli, C | 1 |
| Jack, CR; Kantarci, K; Kantarci, OH; Kemp, BJ; Kremers, WK; Lesnick, TG; Lowe, VJ; Min, PH; Przybelski, SA; Schwarz, CG; Senjem, ML; Zeydan, B | 1 |
| Burcklen, M; Freedman, MS; Havrdova, EK; Hennessy, B; Larbalestier, A; Lemle, A; Olsson, T; Pozzilli, C; Sidorenko, T; Vaclavkova, A | 1 |
| Anand, B; Annadure, RK; Arulselvan, V; Deepalam, S; Gupta, S; Ichaporia, N; Iyer, RB; John, SK; Kamath, V; Kumar, S; Mathew, T; Murgod, U; Nadig, R; Nair, SS; Neeharika, ML; Netravathi, M; Parry, G; Raghavendra, S; Reddy, YM; Renukaradhya, U; Rohatgi, A; Sarma, GRK; Satishchandra, P; Sharath Kumar, GG; Shivakumar, R; Singh, P; Singhal, BS; Surya, N; Yareeda, S | 1 |
| Burcklen, M; Kracker, H; Olsson Gisleskog, P; Pérez-Ruixo, JJ; Poggesi, I; Sidorenko, T; Valenzuela, B | 1 |
| Akkoc, Y | 1 |
| Bodini, B; Bottlaender, M; Lazzarotto, A; Papeix, C; Poirion, E; Ricigliano, V; Stankoff, B; Tonietto, M | 1 |
| Alnaif, A; D'Souza, MS; Oiler, I | 1 |
| Luyckx, N; Pérez-Ruixo, JJ; Poggesi, I; Vaclavkova, A; Valenzuela, B | 1 |
| Asensio Sánchez, S; García Ródenas, MDM; Gómez Román, M; Moreno Navarro, L; Pérez Sempere, Á | 1 |
| Kruger, TM; Ouwerkerk-Mahadevan, S; Ruixo, JJP; Thompson, CD; Valenzuela, B | 1 |
| Gunter, JL; Jack, CR; Kantarci, K; Kantarci, OH; Knopman, DS; Lesnick, TG; Lowe, VJ; Machulda, MM; Mielke, MM; Parisi, JE; Petersen, RC; Przybelski, SA; Reichard, RR; Schwarz, CG; Senjem, ML; Vemuri, P; Zeydan, B | 1 |
| Brucker, BM; Charlson, ER; Enemchukwu, E; Howard, J; Jericevic, D; Krupp, L; Pape, D; Peyronnet, B; Rosenblum, N; Rude, T; Zhovtis-Ryerson, L | 1 |
| Jhaveri, A; Kenison, JE; Khadse, N; Li, Z; Nowakowska, D; Plasencia, A; Quintana, FJ; Sherr, DH; Stanton, VP; Tezza, S; Tjon, E | 1 |
| Dellis, A; Fragkoulis, C; Gkialas, I; Glykas, I; Mitsikostas, DD; Mitsogiannis, I; Ntoumas, K; Papadopoulos, G; Papatsoris, A; Skolarikos, A | 1 |
| Bílková, K; Borovička, V; Cífková, R; Krhut, J; Kufová, E; Mokriš, J; Pudich, J; Sýkora, R; Wohlfahrt, P; Zachoval, R; Zvara, P | 1 |
| Buchpiguel, CA; de Paula Faria, D; Estessi de Souza, L; Navarro Marques, FL; Real, CC; Teles Garcez, A | 1 |
| Leirens, Q; Ouwerkerk-Mahadevan, S; Pérez-Ruixo, JJ; Poggesi, I; Valenzuela, B | 1 |
| Burcklen, M; Gisleskog, PO; Pérez-Ruixo, JJ; Poggesi, I; Scherz, T; Valenzuela, B | 1 |
| Cohen, JA; McGinley, MP | 1 |
| Collins-Praino, LE; Corrigan, F; Guglietti, B; Mustafa, S; Sivasankar, S | 1 |
| Benarroch, EE; Gunter, JL; Jack, CR; Kantarci, K; Kantarci, OH; Knopman, DS; Lesnick, TG; Lowe, VJ; Machulda, MM; Mielke, MM; Petersen, RC; Przybelski, SA; Roberts, RO; Rodriguez, M; Schwarz, CG; Senjem, ML; Tosakulwong, N; Zeydan, B; Zuk, SM | 1 |
| Chaudhry, BZ; Cohen, JA; Conway, DS | 1 |
| Baltogiannis, D; Dimitriadis, F; Filiponi, M; Giannakis, J; Sofikitis, N; Takenaka, A; Tsounapi, P; Zachariou, A | 1 |
| Ethans, K; Hickling, D; McKibbon, M; Radomski, S; Welk, B | 1 |
| Bar-Or, A; Filippi, M; Piehl, F; Preziosa, P; Rocca, MA; Solari, A; Vukusic, S | 1 |
| Bertoldo, A; Bodini, B; Brooks, DJ; Edison, P; Marchitelli, L; Schubert, JJ; Stankoff, B; Tonietto, M; Turkheimer, FE; Veronese, M | 1 |
| Billard, T; Bolbos, R; Bonnefoi, F; Bouillot, C; Chauveau, F; Hugon, G; Langlois, JB; Li, B; Zhang, M; Zimmer, L | 1 |
| Bello, AM; Chakka, SK; Kotra, LP; Moscarello, MA; Wasilewski, E; Wei, L | 1 |
| Ahlgen, C; Åhlin, K; Bessidskaia, G; Claesson, M; Hettman, A; Ivanov, V; Jerning, E; Johansson, R; Karlström, S; Kers, A; Lo-Alfredsson, Y; Malmberg, Å; Nordvall, G; Petersson, C; Ray, C; Rein, T; Slivo, C; Sohn, D; Svensson, PH; Turek, D; Vares, L | 1 |
| Fujimura, H; Honorat, JA; Kinoshita, M; Koda, T; Mochizuki, H; Nakatsuji, Y; Okuno, T; Sakoda, S; Shirakura, T; Tada, S; Takata, K | 1 |
| Diefenderfer, LA; Iuppa, CA | 1 |
| Buchpiguel, CA; Copray, S; de Vries, EF; Dierckx, RA; Faria, Dde P; Sijbesma, JW; Willemsen, AT | 1 |
| Bartos, A; Gazova, Z; Kotoucova, J; Kristofikova, Z; Ricny, J; Ripova, D; Siposova, K; Sirova, J | 1 |
| Brossard, P; D'Ambrosio, D; Dingemanse, J; Krause, A | 1 |
| Abdollahi, M; Nikfar, S; Safavi, M | 1 |
| Abdollahi, M; Ganjali, Z; Javan, MR; Khalseh, R; Khani, M; Ramroodi, N; Ravan, H; Sanadgol, E; Sanadgol, N | 1 |
| Cabrera-Martín, MN; Carreras, JL; Matías-Guiu, J; Matías-Guiu, JA; Oreja-Guevara, C | 1 |
| Aigrot, MS; Armand, L; Bottlaender, M; Chardain, A; Dollé, F; Freeman, L; Galanaud, D; Lehericy, S; Lubetzki, C; Stankoff, B; Williams, A; Zalc, B | 1 |
| Ansorge, S; Bank, U; Biton, A; Brocke, S; Reinhold, D; Täger, M | 1 |
| Benrabah, R; Clavelou, P; Dubreuil, P; Hermine, O; Moussy, A; Schmidt, N; Vermersch, P; Vongsouthi, C; Zéphir, H | 1 |
| Brosnan, CF; Dumitrescu-Ozimek, L; Feinstein, DL; Galea, E; Gavrilyuk, V; Heneka, MT; Landreth, GE; Pershadsingh, HA; Weinberg, G; Whitacre, CC | 1 |
| Davids, E; Gastpar, M; Hartwig, U | 1 |
| Chesik, D; De Keyser, J; Glazenburg, L; Wilczak, N | 1 |
| Ansorge, S; Born, I; Faust, J; Gran, B; Hemmer, B; Martin, R; McFarland, HF; Neubert, K; Reinhold, D | 1 |
| Alcázar, A; Alvarez-Cermeño, JC; Masjuan, J; Regidor, I; Salinas, M | 1 |
| Ansorge, S; Born, I; Brocke, S; Faust, J; Gado, A; Izikson, L; Martin, R; Neubert, K; Quigley, L; Reinhold, D; Steinbrecher, A; Tresser, N | 1 |
| Ansorge, S; Born, I; Brocke, S; Faust, J; Gran, B; Hemmer, B; Kähne, T; Martin, R; Neubert, K; Reinhold, D; Steinbrecher, A; Wrenger, S | 1 |
| Ballerini, C; Chiarugi, A; Cozzi, A; Massacesi, L; Moroni, F | 1 |
9 review(s) available for thiazoles and Multiple Sclerosis
| Article | Year |
|---|---|
Ponesimod to treat multiple sclerosis.
Topics: Humans; Multiple Sclerosis; Receptors, Lysosphingolipid; Recurrence; Thiazoles | 2021 |
Efficacy and safety of mirabegron for treatment of neurogenic detrusor overactivity in adults with spinal cord injury or multiple sclerosis: a systematic review.
Topics: Acetanilides; Adult; Cholinergic Antagonists; Humans; Multiple Sclerosis; Randomized Controlled Trials as Topic; Retrospective Studies; Spinal Cord Injuries; Thiazoles; Treatment Outcome; Urinary Bladder, Neurogenic; Urinary Bladder, Overactive; Urodynamics | 2022 |
Ponesimod: An Oral Second-Generation Selective Sphingosine 1-Phosphate Receptor Modulator for the Treatment of Multiple Sclerosis.
Topics: Humans; Immunologic Factors; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles | 2023 |
Clinical Pharmacokinetics of Ponesimod, a Selective S1P1 Receptor Modulator, in the Treatment of Multiple Sclerosis.
Topics: Humans; Immunologic Factors; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Thiazoles | 2023 |
Sphingosine 1-phosphate receptor modulators in multiple sclerosis and other conditions.
Topics: Animals; Azetidines; Benzyl Compounds; Clinical Trials as Topic; Fingolimod Hydrochloride; Humans; Immune System Diseases; Indans; Multiple Sclerosis; Nervous System Diseases; Oxadiazoles; Signal Transduction; Sphingosine 1 Phosphate Receptor Modulators; Sphingosine-1-Phosphate Receptors; Thiazoles | 2021 |
Fyn Kinase Activity and Its Role in Neurodegenerative Disease Pathology: a Potential Universal Target?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzamides; Central Nervous System; Dasatinib; Humans; Molecular Targeted Therapy; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Neurodegenerative Diseases; Oligodendroglia; Parkinson Disease; Piperidines; Proto-Oncogene Proteins c-fyn; PrPC Proteins; Pyridines; Receptors, N-Methyl-D-Aspartate; T-Cell Antigen Receptor Specificity; T-Lymphocyte Subsets; tau Proteins; Thiazoles | 2021 |
Sphingosine 1-Phosphate Receptor Modulators for the Treatment of Multiple Sclerosis.
Topics: Animals; Azetidines; Benzyl Compounds; Clinical Trials as Topic; Fingolimod Hydrochloride; Humans; Immunologic Factors; Indans; Indoles; Multiple Sclerosis; Naphthalenes; Oxadiazoles; Propanolamines; Receptors, Lysosphingolipid; Thiazoles; Treatment Outcome | 2017 |
Multiple sclerosis.
Topics: Azetidines; Benzyl Compounds; Demyelinating Diseases; Humans; Indans; Magnetic Resonance Imaging; Multiple Sclerosis; Oxadiazoles; Risk Factors; Thiazoles; Tomography, X-Ray Computed | 2018 |
A systematic review of drugs in late-stage development for the treatment of multiple sclerosis: a focus on oral synthetic drugs.
Topics: Benzamides; Humans; Immunologic Factors; Multiple Sclerosis; Piperidines; Pyridines; Quinolones; Small Molecule Libraries; Thiazoles | 2015 |
8 trial(s) available for thiazoles and Multiple Sclerosis
| Article | Year |
|---|---|
Long-term Treatment With Ponesimod in Relapsing-Remitting Multiple Sclerosis: Results From Randomized Phase 2b Core and Extension Studies.
Topics: Humans; Magnetic Resonance Imaging; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Recurrence; Thiazoles; Treatment Outcome | 2022 |
An exposure-response analysis of ponesimod clinical efficacy in a randomized phase III study in patients with relapsing multiple sclerosis.
Topics: Adult; Crotonates; Humans; Hydroxybutyrates; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Nitriles; Recurrence; Thiazoles; Toluidines; Treatment Outcome | 2022 |
Mirabegron Versus Solifenacin in Multiple Sclerosis Patients With Overactive Bladder Symptoms: A Prospective Comparative Nonrandomized Study.
Topics: Acetanilides; Adult; Constipation; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Patient Reported Outcome Measures; Prospective Studies; Severity of Illness Index; Solifenacin Succinate; Thiazoles; Treatment Outcome; Urinary Bladder, Overactive; Urological Agents | 2020 |
B3 agonists or anticholinergics in the treatment of the lower urinary tract dysfunction in patients with multiple sclerosis?-A randomized study.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Cholinergic Antagonists; Drug Monitoring; Female; Humans; Lower Urinary Tract Symptoms; Male; Middle Aged; Multiple Sclerosis; Single-Blind Method; Symptom Assessment; Thiazoles; Treatment Outcome; Ultrasonography | 2021 |
Cardiovascular safety of mirabegron in individuals treated for spinal cord injury- or multiple sclerosis-induced neurogenic detrusor overactivity.
Topics: Acetanilides; Adolescent; Adrenergic beta-3 Receptor Agonists; Adult; Aged; Cardiovascular Diseases; Double-Blind Method; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Prospective Studies; Spinal Cord Injuries; Thiazoles; Urinary Bladder, Overactive; Young Adult | 2021 |
An Exposure-Response Analysis of the Clinical Efficacy of Ponesimod in a Randomized Phase II Study in Patients with Multiple Sclerosis.
Topics: Humans; Infant; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Thiazoles; Treatment Outcome | 2021 |
A pilot randomized-controlled trial of the urodynamic efficacy of mirabegron for patients with neurogenic lower urinary tract dysfunction.
Topics: Acetanilides; Adult; Aged; Canada; Double-Blind Method; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Pilot Projects; Spinal Cord Injuries; Thiazoles; Treatment Outcome; Urinary Bladder, Neurogenic; Urinary Bladder, Overactive; Urinary Incontinence; Urodynamics | 2018 |
Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study.
Topics: Administration, Oral; Benzamides; Female; France; Humans; Male; Middle Aged; Multiple Sclerosis; Pilot Projects; Piperidines; Placebo Effect; Pyridines; Thiazoles; Treatment Outcome | 2012 |
33 other study(ies) available for thiazoles and Multiple Sclerosis
| Article | Year |
|---|---|
Changes in John Cunningham Virus Index in Multiple Sclerosis Patients Treated with Different Disease-Modifying Therapies.
Topics: Adult; Female; Humans; Immunologic Factors; JC Virus; Leukoencephalopathy, Progressive Multifocal; Longitudinal Studies; Male; Middle Aged; Multiple Sclerosis; Natalizumab; Nitro Compounds; Thiazoles | 2022 |
Comparison of
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Humans; Middle Aged; Multiple Sclerosis; Positron-Emission Tomography; Thiazoles; White Matter | 2022 |
A real world multi center study on efficacy and safety of natalizumab in Indian patients with multiple sclerosis.
Topics: Adolescent; Adult; Female; Humans; Immunologic Factors; Leukoencephalopathy, Progressive Multifocal; Male; Middle Aged; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Natalizumab; Nitro Compounds; Thiazoles | 2022 |
Periventricular remyelination failure in multiple sclerosis: a substrate for neurodegeneration.
Topics: Aniline Compounds; Brain; Humans; Magnetic Resonance Imaging; Multiple Sclerosis; Myelin Sheath; Remyelination; Thiazoles; White Matter | 2023 |
Pharmacokinetic-Pharmacodynamic Modeling of the Ponesimod Effect on Heart Rate in Patients With Multiple Sclerosis.
Topics: Heart Rate; Humans; Multiple Sclerosis; Receptors, Lysosphingolipid; Thiazoles | 2023 |
Dyspnea and Bronchoconstriction in a Young Patient With Multiple Sclerosis Treated With Ponesimod.
Topics: Bronchoconstriction; Dyspnea; Humans; Multiple Sclerosis; Thiazoles | 2023 |
Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Brain; Carbolines; Case-Control Studies; Cerebral Cortex; Contrast Media; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Odds Ratio; Positron-Emission Tomography; Radiopharmaceuticals; tau Proteins; Thiazoles | 2020 |
Tolerogenic nanoparticles suppress central nervous system inflammation.
Topics: Animals; Bystander Effect; Drug Combinations; Encephalomyelitis, Autoimmune, Experimental; Epitopes, T-Lymphocyte; Female; Humans; Immune Tolerance; Immunosuppressive Agents; Indoles; Liposomes; Mice; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Nanoparticles; Peptide Fragments; Receptors, Aryl Hydrocarbon; Signal Transduction; T-Lymphocytes, Regulatory; Thiazoles | 2020 |
Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis.
Topics: Aniline Compounds; Animals; Disease Models, Animal; Image Processing, Computer-Assisted; Lysophosphatidylcholines; Magnetic Resonance Imaging; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Positron-Emission Tomography; Rats; Stereotaxic Techniques; Thiazoles | 2021 |
Effect of Ponesimod Exposure on Total Lymphocyte Dynamics in Patients with Multiple Sclerosis.
Topics: Humans; Lymphocyte Count; Lymphocytes; Multiple Sclerosis; Thiazoles | 2021 |
Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis.
Topics: Aged; Aging; Aniline Compounds; Brain; Cognition; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; White Matter | 2018 |
Effective treatment of neurogenic detrusor overactivity in multiple sclerosis patients using desmopressin and mirabegron.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Adult; Antidiuretic Agents; Deamino Arginine Vasopressin; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Muscarinic Antagonists; Retreatment; Solifenacin Succinate; Thiazoles; Urinary Bladder, Neurogenic; Urinary Bladder, Overactive; Urinary Incontinence; Urination | 2017 |
Dynamic
Topics: Adult; Aged; Algorithms; Alzheimer Disease; Aniline Compounds; Area Under Curve; Brain; Case-Control Studies; Cerebrospinal Fluid; Cognitive Dysfunction; Databases, Factual; Female; Homeostasis; Humans; Kinetics; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles | 2019 |
Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls!
Topics: Aniline Compounds; Animals; Autoradiography; Brain Edema; Carbon Radioisotopes; Cerebral Ventricles; Corpus Callosum; Corpus Striatum; Demyelinating Diseases; Dilatation, Pathologic; Disease Models, Animal; Ethylene Glycols; False Positive Reactions; Fluorine Radioisotopes; Image Processing, Computer-Assisted; Injections; Lysophosphatidylcholines; Magnetic Resonance Imaging; Male; Multiple Sclerosis; Myelin Sheath; Neuroimaging; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Thiazoles | 2019 |
Novel inhibitors of protein arginine deiminase with potential activity in multiple sclerosis animal model.
Topics: Animals; Brain; Catalytic Domain; CD3 Complex; Computer Simulation; Encephalomyelitis, Autoimmune, Experimental; Hydrolases; Imidazoles; Indoles; Mice; Models, Molecular; Multiple Sclerosis; Pilot Projects; Piperazines; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Pyridines; Pyrimidines; Small Molecule Libraries; Stereoisomerism; T-Lymphocytes; Thiazoles | 2013 |
Substituted 7-amino-5-thio-thiazolo[4,5-d]pyrimidines as potent and selective antagonists of the fractalkine receptor (CX3CR1).
Topics: Amino Alcohols; Animals; Caco-2 Cells; CX3C Chemokine Receptor 1; Humans; Multiple Sclerosis; Pyrimidines; Rats; Receptors, Chemokine; Structure-Activity Relationship; Thiazoles | 2013 |
Xanthine oxidase mediates axonal and myelin loss in a murine model of multiple sclerosis.
Topics: Animals; Axons; Central Nervous System; Encephalomyelitis, Autoimmune, Experimental; Febuxostat; Female; Mice; Multiple Sclerosis; Myelin Sheath; Reactive Oxygen Species; Thiazoles; Xanthine Oxidase | 2013 |
Risperidone-induced Pisa syndrome in MS: resolution with lurasidone and recurrence with Chlorpromazine.
Topics: Adult; Antipsychotic Agents; Child Development Disorders, Pervasive; Chlorpromazine; Gait Ataxia; Humans; Isoindoles; Lurasidone Hydrochloride; Male; Multiple Sclerosis; Recurrence; Risperidone; Syndrome; Thiazoles | 2013 |
PET imaging of focal demyelination and remyelination in a rat model of multiple sclerosis: comparison of [11C]MeDAS, [11C]CIC and [11C]PIB.
Topics: Aniline Compounds; Animals; Benzothiazoles; Encephalomyelitis, Autoimmune, Experimental; Male; Multiple Sclerosis; Myelin Sheath; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Stilbenes; Thiazoles | 2014 |
Effects of ferrofluid and phytoalexin spirobrassinin on thioflavin-T-based fluorescence in cerebrospinal fluid of the elderly and multiple sclerosis patients.
Topics: Adult; Aged; Aging; Benzothiazoles; Chlorides; Female; Ferric Compounds; Ferrous Compounds; Fluorescence; Fluorescent Dyes; Humans; Male; Middle Aged; Multiple Sclerosis; Spiro Compounds; Thiazoles | 2014 |
Population pharmacokinetics and pharmacodynamics of ponesimod, a selective S1P1 receptor modulator.
Topics: Adolescent; Adult; Aged; Body Weight; Circadian Rhythm; Female; Humans; Intestinal Absorption; Lymphocyte Count; Male; Middle Aged; Models, Statistical; Multiple Sclerosis; Population; Receptors, Lysosphingolipid; Thiazoles; Young Adult | 2014 |
Prophylactic Effect of BIO-1211 Small-Molecule Antagonist of VLA-4 in the EAE Mouse Model of Multiple Sclerosis.
Topics: Animals; Blood-Brain Barrier; CD11b Antigen; Cell Movement; Cerebral Cortex; Cytokines; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Inflammation Mediators; Integrin alpha4beta1; Leukocyte Common Antigens; Leukocytes; Male; Mice; Monocytes; Multiple Sclerosis; Nitro Compounds; Oligopeptides; Permeability; RNA, Messenger; Thiazoles | 2015 |
Pittsburgh compound B and other amyloid positron emission tomography tracers for the study of white matter and multiple sclerosis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Humans; Multiple Sclerosis; Positron-Emission Tomography; Thiazoles; White Matter | 2016 |
Imaging central nervous system myelin by positron emission tomography in multiple sclerosis using [methyl-¹¹C]-2-(4'-methylaminophenyl)- 6-hydroxybenzothiazole.
Topics: Aniline Compounds; Animals; Benzothiazoles; Brain; Cadaver; Carbon Radioisotopes; Demyelinating Diseases; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Multiple Sclerosis; Nerve Regeneration; Papio anubis; Positron-Emission Tomography; Thiazoles | 2011 |
Divergent actions by inhibitors of DP IV and APN family enzymes on CD4+ Teff cell motility and functions.
Topics: Animals; CD13 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Chemokine CXCL12; Chemotaxis; Dipeptidyl Peptidase 4; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Humans; Hydroxamic Acids; Lymphocyte Activation; Lysine; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Pyrroles; Pyrrolidines; Thiazoles; Transgenes | 2011 |
Peroxisome proliferator-activated receptor-gamma agonists prevent experimental autoimmune encephalomyelitis.
Topics: Animals; Cerebellum; Cerebral Cortex; DNA-Binding Proteins; Encephalomyelitis, Autoimmune, Experimental; Female; Glycoproteins; Humans; Hypoglycemic Agents; I-kappa B Proteins; Ligands; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Myelin-Oligodendrocyte Glycoprotein; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxazoles; Peptide Fragments; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Remission Induction; Spinal Cord; T-Lymphocytes; Thiazoles; Thiazolidinediones; Transcription Factors; Tyrosine | 2002 |
Antipsychotic treatment of psychosis associated with multiple sclerosis.
Topics: Antipsychotic Agents; Female; Humans; Middle Aged; Multiple Sclerosis; Piperazines; Psychotic Disorders; Schizophrenic Psychology; Thiazoles | 2004 |
Insulin-like growth factor binding proteins: regulation in chronic active plaques in multiple sclerosis and functional analysis of glial cells.
Topics: Adult; Aged; Aged, 80 and over; Animals; Animals, Newborn; Cell Count; Cell Proliferation; Cells, Cultured; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Proteins; Male; Middle Aged; Multiple Sclerosis; Neuroglia; Oligodendroglia; Postmortem Changes; Rats; Stem Cells; Tetrazolium Salts; Thiazoles | 2006 |
Inhibitors of dipeptidyl peptidase IV/CD26 suppress activation of human MBP-specific CD4+ T cell clones.
Topics: CD4 Antigens; Clone Cells; Cytokines; Dipeptidyl Peptidase 4; DNA; Humans; Lysine; Multiple Sclerosis; Myelin Basic Protein; Protease Inhibitors; Pyrrolidines; T-Lymphocytes; Thiazoles | 1998 |
Axonal damage induced by cerebrospinal fluid from patients with relapsing-remitting multiple sclerosis.
Topics: Adolescent; Adult; Animals; Apoptosis; Axons; Cells, Cultured; Cerebrospinal Fluid; Coloring Agents; Humans; Metallothionein; Microscopy, Confocal; Middle Aged; Multiple Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Neurons; Rats; Tetrazolium Salts; Thiazoles | 2000 |
Dipeptidyl peptidase IV in inflammatory CNS disease.
Topics: Animals; Animals, Outbred Strains; Autoimmune Diseases; Dipeptidyl Peptidase 4; Encephalomyelitis, Autoimmune, Experimental; Female; Humans; Lymphocyte Activation; Lysine; Mice; Multiple Sclerosis; Myelin Basic Protein; Pyrrolidines; Rats; Serine Proteinase Inhibitors; T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer; Thiazoles | 2000 |
Dipeptidyl peptidase IV (CD26): role in T cell activation and autoimmune disease.
Topics: Autoimmune Diseases; CD4-Positive T-Lymphocytes; Dipeptidyl Peptidase 4; DNA Replication; Flow Cytometry; Humans; Immunodominant Epitopes; Lymphocyte Activation; Lymphokines; Lysine; Multiple Sclerosis; Myelin Basic Protein; Phytohemagglutinins; Pyrrolidines; Serine Proteinase Inhibitors; Thiazoles | 2000 |
Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis.
Topics: Animals; Astrocytes; Brain; Cytoplasmic Granules; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Immunohistochemistry; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Multiple Sclerosis; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Spinal Cord; Sulfonamides; Thiazoles | 2001 |