thiazoles has been researched along with Iron Overload in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (16.67) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dev, A; Jayaprakash, V; Shyam, M; Sinha, BN | 1 |
| Bergeron, RJ; Bharti, N; McManis, JS; Wiegand, J | 2 |
| Bergeron, RJ; Bharti, N; McManis, JS; Singh, S; Wiegand, J | 1 |
| Abboud, KA; Bergeron, RJ; Bharti, N; McManis, JS; Singh, S; Wiegand, J | 1 |
| Chirnomas, D; Harmatz, P; Kramer, W; Kwiatkowski, JL; Neufeld, EJ; Porter, JB; Rienhoff, HY; Tapper, A; Tay, L; Vichinsky, E; Viprakasit, V | 1 |
| Aydinok, Y; Forni, GL; Galanello, R; Grace, RF; Harmatz, P; Jones, A; Neufeld, EJ; Peppe, J; Piga, A; Porter, JB; Rienhoff, HY; Shah, FT; Viprakasit, V; Wood, JC | 1 |
| Bergeron, RJ; Huang, G; McManis, JS; Weimar, WR; Wiegand, J | 1 |
| Bergeron, RJ; Bussenius, J; McManis, JS; Smith, RE; Weimar, WR; Wiegand, J | 1 |
| Economides, C; Eracleous, E; Kolnagou, A; Kontoghiorghes, GJ | 1 |
| Bree, M; Dagher, R; Donovan, JM; Marquis, J; Plone, M | 1 |
| Kontoghiorghes, GJ | 2 |
| Barton, JC | 2 |
| Bergeron, RJ; Bussenius, J; McManis, JS; Vinson, JR; Weimar, WR; Wiegand, J; Yao, GW | 1 |
| Crichton, RR; Dexter, DT; Florence, A; Jenner, P; Ward, RJ | 1 |
| Bergeron, RJ; Brittenham, GM; Bussenius, J; McManis, JS; Wiegand, J | 1 |
7 review(s) available for thiazoles and Iron Overload
| Article | Year |
|---|---|
Scaffold Based Search on the Desferithiocin Archetype.
Topics: Benzene Derivatives; Dihydropyridines; Humans; Iron Chelating Agents; Iron Overload; Pyridines; Structure-Activity Relationship; Thiazoles | 2019 |
Desferrithiocin: a search for clinically effective iron chelators.
Topics: Animals; Chemistry, Pharmaceutical; Dihydropyridines; Drug Design; Electron Transport; Ferritins; Homeostasis; Humans; Iron; Iron Chelating Agents; Iron Overload; Ligands; Oxidation-Reduction; Primates; Rats; Rats, Sprague-Dawley; Siderophores; Structure-Activity Relationship; Thiazoles; Transferrin | 2014 |
Structure-activity relationships among desazadesferrithiocin analogues.
Topics: Animals; Dihydropyridines; Drug Design; Humans; Iron; Iron Chelating Agents; Iron Overload; Ligands; Siderophores; Structure-Activity Relationship; Thiazoles | 2002 |
Advances in iron overload therapies. prospects for effective use of deferiprone (L1), deferoxamine, the new experimental chelators ICL670, GT56-252, L1NA11 and their combinations.
Topics: Benzoates; Carboxylic Acids; Deferasirox; Deferiprone; Deferoxamine; Drug Therapy, Combination; Hemochromatosis; Humans; Iron Chelating Agents; Iron Overload; Pyridones; Siderophores; Thalassemia; Thiazoles; Triazoles | 2005 |
Preclinical and clinical development of deferitrin, a novel, orally available iron chelator.
Topics: Administration, Oral; Animals; beta-Thalassemia; Carboxylic Acids; Chelation Therapy; Clinical Trials, Phase I as Topic; Dogs; Drug Evaluation, Preclinical; Feces; Humans; Iron; Iron Chelating Agents; Iron Overload; Macaca fascicularis; Molecular Structure; Rats; Thiazoles | 2005 |
Future chelation monotherapy and combination therapy strategies in thalassemia and other conditions. comparison of deferiprone, deferoxamine, ICL670, GT56-252, L1NAll and starch deferoxamine polymers.
Topics: Benzoates; Carboxylic Acids; Chelation Therapy; Clinical Trials as Topic; Deferasirox; Deferiprone; Deferoxamine; Drug Evaluation; Drug Therapy, Combination; Forecasting; Hemochromatosis; Humans; Hydroxyethyl Starch Derivatives; Iron Chelating Agents; Iron Overload; Molecular Structure; Pyridones; Starch; Thalassemia; Thiazoles; Transfusion Reaction; Triazoles | 2006 |
Drug evaluation: deferitrin (GT-56-252; NaHBED) for iron overload disorders.
Topics: Animals; Carboxylic Acids; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Drug Evaluation, Preclinical; Humans; Iron Chelating Agents; Iron Overload; Structure-Activity Relationship; Thiazoles | 2007 |
2 trial(s) available for thiazoles and Iron Overload
| Article | Year |
|---|---|
A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload.
Topics: Administration, Oral; Adult; Ethyl Ethers; Female; Humans; Iron Chelating Agents; Iron Overload; Male; Thiazoles; Transfusion Reaction; Young Adult | 2011 |
A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload.
Topics: Adolescent; Adult; Creatinine; Dose-Response Relationship, Drug; Ethyl Ethers; Female; Hemoglobinopathies; Humans; Iron; Iron Chelating Agents; Iron Overload; Liver; Male; Middle Aged; Thiazoles; Transfusion Reaction; Treatment Outcome; Young Adult | 2012 |
9 other study(ies) available for thiazoles and Iron Overload
| Article | Year |
|---|---|
Desferrithiocin analogues and nephrotoxicity.
Topics: Administration, Oral; Animals; Cebus; Dihydropyridines; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Iron; Iron Chelating Agents; Iron Overload; Kidney Diseases; Ligands; Lipids; Male; Molecular Conformation; Rats; Rats, Sprague-Dawley; Stereoisomerism; Thiazoles; Water | 2008 |
The impact of polyether chain length on the iron clearing efficiency and physiochemical properties of desferrithiocin analogues.
Topics: Animals; Bile Ducts; Cebus; Chemical Phenomena; Crystallography, X-Ray; Dihydropyridines; Drug Design; Ether; Ethers; Humans; Iron; Iron Chelating Agents; Iron Overload; Kidney; Ligands; Male; Octanols; Rats; Thiazoles; Water | 2010 |
Substituent effects on desferrithiocin and desferrithiocin analogue iron-clearing and toxicity profiles.
Topics: Administration, Oral; Animals; Cebus; Coordination Complexes; Dihydropyridines; Ethers; Ferric Compounds; Hydroxylation; Iron Chelating Agents; Iron Overload; Kidney; Ligands; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2012 |
Methoxylation of desazadesferrithiocin analogues: enhanced iron clearing efficiency.
Topics: 1-Octanol; Animals; Ascorbic Acid; Cebus; Feces; Free Radical Scavengers; Iron; Iron Chelating Agents; Iron Overload; Ligands; Oxidation-Reduction; Pyridines; Solubility; Solvents; Structure-Activity Relationship; Thiazoles; Urine; Water | 2003 |
New chelation therapies and emerging chelating drugs for the treatment of iron overload.
Topics: beta-Thalassemia; Carboxylic Acids; Clinical Trials as Topic; Deferiprone; Deferoxamine; Drug Design; Drug Therapy, Combination; Humans; Iron Chelating Agents; Iron Overload; Pyridones; Thiazoles; Transfusion Reaction | 2006 |
Drug evaluation: Deferitrin for iron overload disorders.
Topics: Animals; Carboxylic Acids; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Iron Chelating Agents; Iron Overload; Molecular Structure; Structure-Activity Relationship; Thiazoles | 2007 |
Desazadesmethyldesferrithiocin analogues as orally effective iron chelators.
Topics: Administration, Oral; Animals; Bile; Carboxylic Acids; Cebus; Drug Design; Drug Evaluation, Preclinical; Iron; Iron Chelating Agents; Iron Overload; Male; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 1999 |
Effects of desferrithiocin and its derivatives on peripheral iron and striatal dopamine and 5-hydroxytryptamine metabolism in the ferrocene-loaded rat.
Topics: Administration, Oral; Animals; Corpus Striatum; Dihydropyridines; Dopamine; Ferrous Compounds; In Vitro Techniques; Iron; Iron Chelating Agents; Iron Overload; Male; Metallocenes; Rats; Rats, Wistar; Serotonin; Thiazoles | 1999 |
Evaluation of the desferrithiocin pharmacophore as a vector for hydroxamates.
Topics: Administration, Oral; Animals; Cebus; Dihydropyridines; Drug Evaluation, Preclinical; Hydroxamic Acids; Injections, Subcutaneous; Iron Chelating Agents; Iron Overload; Ligands; Male; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles | 1999 |