thiazoles has been researched along with Disease Models, Animal in 880 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 22 (2.50) | 18.7374 |
| 1990's | 75 (8.52) | 18.2507 |
| 2000's | 266 (30.23) | 29.6817 |
| 2010's | 437 (49.66) | 24.3611 |
| 2020's | 80 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Karnam, M; Thamaraikani, T; Velapandian, C | 1 |
| Che, X; Fan, G; Gong, F; Huang, Y; Jia, K; Li, X; Lu, H; Shen, T; Wang, X; Xu, Z; Zhang, J | 1 |
| Bieber, M; Foerster, KI; Haefeli, WE; Kraft, P; Pham, M; Schuhmann, MK | 1 |
| Calvisi, DF; Chen, K; Chen, X; Evert, M; Li, B; Shang, R; Song, X; Xu, H; Zhang, Y; Zhong, S | 1 |
| Fong, IH; Lee, WH; Lin, IH; Pikatan, NW; Weng, PW; Yadav, VK; Yeh, CT | 1 |
| Fan, M; He, Y; Li, M; Li, X; Liu, H; Liu, Y; Shi, K | 1 |
| Bang, ML; Frossard, N; Gassmann, M; Nemska, S; Tavakoli, R | 1 |
| da Motta, KP; Domingues, NLC; Luchese, C; Santos, BF; Wilhelm, EA | 1 |
| Hosoya, O; Liu, S; Matsuo, T; Miyaji, M | 1 |
| Chen, J; Jiang, N; Li, L; Luo, J; Tan, J; Yang, C; Zhao, J; Zhao, Y | 1 |
| Antonova, IV; Dyomina, AV; Griflyuk, AV; Kovalenko, AA; Postnikova, TY; Smolensky, IV; Zaitsev, AV; Zakharova, MV | 1 |
| Aldiss, P; Bloor, I; Boocock, DJ; Budge, H; Chavoshinejad, R; Ebling, FJP; Lewis, JE; Lupini, I; Miles, AK; Symonds, ME | 1 |
| Batra, R; Baxter, BT; Cook, JR; Foley, RT; Greene, H; Harding, P; Jespersen, K; Li, C; Meisinger, T; Sestak, K; Stephenson, CA; Xiong, W | 1 |
| Fang, L; Kawanishi, H; Murohara, T; Ogawa, H; Ohashi, K; Otaka, N; Ouchi, N; Ozaki, Y; Takahara, K; Takefuji, M; Takikawa, T; Tatsumi, M | 1 |
| An, J; Cho, HJ; Hur, KJ; Jang, JA; Kim, JS; Kim, YJ; Kwon, J; Lee, EJ; Park, D; Park, HR; Yang, H; Yoshimura, N | 1 |
| Dong, L; Kang, K; Li, N; Li, X; Ma, P; Ma, Y; Qian, B; Shen, B; Wang, C; Wu, H | 1 |
| Gao, Y; Guo, S; Shi, Y; Yang, L; Ye, L; Zhang, T; Zhao, T; Zheng, Y; Zhou, L | 1 |
| Kida, J; Mashimo, H; Matsuya, H; Okada, H; Otsuki, T; Sekido, N | 1 |
| Bolding, IJ; Boone, DR; Cardenas, C; DeWitt, DS; Falduto, MT; Hellmich, HL; Micci, MA; Prough, DS; Sell, SL; Torres, KEO; Weisz, HA; Willey, HE | 1 |
| Burvenich, IJG; Harris, MA; Hawkins, CJ; Parker, BS; Rigopoulos, A; Scott, AM; Shekhar, TM; Spurling, A; Walkley, CR; Zanker, D | 1 |
| Liu, S; Pan, J; Ye, Q; Zhang, J | 1 |
| Fang, W; Li, Z; Wang, D; Wang, X; Wu, J; Wu, Q; Yao, Z | 1 |
| Funahashi, Y; Gotoh, M; Kato, M; Majima, T; Matsukawa, Y; Yamamoto, T | 1 |
| Bai, Y; Chen, B; Guo, Y; Hong, W; Lu, H; Papa, APD; Sun, L; Wu, C; Xiao, Y; Zhang, G; Zheng, S; Zhu, H | 1 |
| Hizue, M; Ito, Y; Kadekawa, K; Nishijima, S; Sugaya, K; Yamada, S; Yamagami, H | 1 |
| Kociszewski, J; Poleszak, E; Serefko, A; Szopa, A; Wiśniewski, R; Woźniak, A; Wróbel, A | 1 |
| Bertoglio, D; Cybulska, K; Dominguez, C; Korat, Š; Liu, L; Miranda, A; Mrzljak, L; Munoz-Sanjuan, I; Skinbjerg, M; Staelens, S; Stroobants, S; Verhaeghe, J; Wyffels, L | 1 |
| Chan, C; Chen, Y; Deshmukh, G; Elstrott, J; Gill, TM; Hackos, DH; Hanson, JE; Jiang, Z; Khan, AS; Kim, TA; Liederer, BM; Liu, B; Ma, K; Palop, JJ; Saillet, S; Scearce-Levie, K; Schwarz, JB; Sellers, BD; Sheng, M; Simms, J; Solanoy, H; Volgraf, M; Wang, TM; Weber, M; Weimer, RM; Yu, GQ | 1 |
| Azam, A; Dwivedi, S; Kausar, S; Khan, W | 1 |
| Jiang, W; Wang, J | 1 |
| Alothmani, R; Aronsson, P; Carlsson, T; Patel, B; Perez, F; Winder, M | 1 |
| Bachmann, P; Böhm, M; Custodis, F; Millenaar, D; Schirmer, SH | 1 |
| Borkham-Kamphorst, E; Danielyan, L; Hunanyan, L; Melkonyan, MM; Mikulits, W; Schaeffeler, E; Schwab, M; Schwinghammer, UA; Seferyan, T; Tremmel, R; Weiskirchen, R; Yenkoyan, K | 1 |
| de Lima, NF; Lino Júnior, RS; Picanço, GA; Sampaio, GA; Vinaud, MC; Zago, LV | 1 |
| Abbasnezhad, A; Abd El-Ghafar, OA; Abhilash, L; Abouzid, KAM; Achberger, AM; Ackerman, S; Akhatayeva, Z; Akin, D; Al-Kaysi, RO; Alakhdar, AA; Alame, M; Aleksic Sabo, V; Alinezhadbalalami, N; Allen, JD; Alonso, JM; Alqatani, S; Alsayed, B; Álvarez Larraondo, M; Alvarez, M; Amini, SB; An, Z; Anasir, MI; Anderson, GH; Andremont, A; Andrés, S; Angel, S; Anigboro, AA; Anini, Y; Antonides, CFJ; Arafa, K; Arafa, RK; Aryal, UK; Asbaghi, O; Assefa, MK; Atyah, M; Avwioroko, OJ; Ayora-Talavera, G; Azpilikueta, A; Azyazov, VN; Ba, YF; Bachmann, KF; Badoual, J; Bae, SJ; Baek, SH; Bahrami, B; Bai, J; Baid-Agrawal, S; Bailey, MR; Baillie, JK; Balani, N; Balcar, VJ; Banica, T; Banks, L; Barb, J; Bardeen, CJ; Barrett, HE; Bartnikowski, N; Bashir, R; Battaglia, M; Bautista-Hernández, V; Becker, B; Beekman, FJ; Benidir, M; Benjelloun, M; Bentley, RF; Bergé, J; Berger, D; Bernsen, MR; Berraondo, P; Bhattacharya, R; Bhayani, SB; Bi, W; Bi, X; Bi, YL; Bi, Z; Bian, K; Biesecker, LG; Billadeau, DD; Blaszczyk, R; Blum, JL; Boachie, R; Boelte, K; Bogers, AJJC; Boileau, I; Bonduelle, C; Bonny, O; Bonsu, JM; Boos, LA; Borges-Argáez, R; Bouchard, PA; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Boyle, AJ; Branigan, D; Briones, S; Broniowska, KA; Brossas, JY; Brown, WA; Brzezinska, J; Buitron, G; Burnier, M; Bursulaya, B; Burton, PR; Bush, AA; Busuttil, RW; Cabello-Aguilar, S; Cáceres-Farfán, M; Cacheux, V; Caffrey, PJ; Cai, B; Cai, Q; Cai, S; Cai, Y; Calders, P; Cammarota, G; Campbell, DA; Cancelli, C; Cao, Q; Cao, WH; Cao, X; Capet, M; Capoluongo, E; Carey, ME; Carnero, M; Carrasco, LI; Carreno, J; Carrillo-Reyes, J; Casini, I; Cassar, M; Catalan, G; Cattamanchi, A; Cazares-Granillo, M; Celie, B; Cen, YK; Cena, H; Cerbo, RM; Ceron, E; Cetina-Montejo, L; Chaâbane-Banaoues, R; Chabanet, C; Chace-Donahue, F; Chalfun-Júnior, A; Chan-Balan, R; Chang, CS; Chen, CS; Chen, D; Chen, J; Chen, L; Chen, PN; Chen, Q; Chen, S; Chen, W; Chen, WP; Chen, X; Chen, Z; Cheng, H; Cheng, J; Cheng, Q; Cheng, T; Chi, T; Chianelli, D; Chieppa, M; Child, CJ; Cho, JH; Cho, JY; Chogtu, B; Choi, GH; Choi, J; Choi, M; Choi, NG; Cholu, CO; Chow, ES; Chowdhury, AH; Chu, PC; Chu, Q; Chu, S; Chua, H; Chung, T; Chunyan, L; Church, JS; Civardi, E; Cobiella, J; Colinge, J; Collado, CJ; Collins, TJ; Cong, LM; Conkrite, KL; Cope, SJ; Corbett, JA; Cornet, M; Cornillot, E; Corvaisier, S; Costes-Martineau, V; Courtioux, B; Coussens, M; Covino, M; Criado, A; Cui, J; Cui, Y; Cunitz, BW; Curry, AE; Cussó, L; D'Urzo, AD; D'Urzo, KA; Dabbous, S; Dahlgren, RA; Dai, H; Dai, T; Dai, W; Dalinghaus, M; Dang, S; Davalos, RV; Davidson, H; de Andrea, CE; De Angelis, M; de Blois, E; de Carvalho, PA; De Clercq, E; De Giuseppe, R; de Jong, M; De Langhe, S; De Oliveira, L; de Souza Pinto Lemgruber, R; de Souza, LB; de Swart, J; De Wandele, I; de Woestijne, PCV; Delaney, S; Delorme, M; Delvenne, P; Deng, L; Deng, Z; Denkinger, CM; der Meulen, MHV; Deraeve, C; Desco, M; DeSilva, S; Destere, A; Dhali, A; Di Ciano, P; Dias-Santagata, D; Diskin, SJ; Djè, MK; Doddipatla, S; Doerr, AJ; Dokla, EME; Domiciano, D; Domingo, N; Dong, C; Dong, J; Dong, Q; Dong, S; Dong, X; Dong, Z; Douair, I; Douglas, TA; Doyle, SM; Drain, PK; Du, K; Du, L; Du, Q; Du, S; Duan, C; Duan, H; Duan, J; Duan, S; Duan, W; Dueluzeau, R; Dukic, L; Dunmire, BL; Duvauchelle, T; Dymek, B; Dzwonek, K; Earnest, A; Eckardt, KU; El Ghadraoui, L; El Massoudi, S; Elloumi, F; Elnour, IE; Embarak, S; Ende, M; England, K; Enikeev, D; Enyedy, I; Epple, R; Erickson, GE; Eriksson, J; Erndt-Marino, J; Errachidi, F; Etxeberria, I; Evan, AP; Fairlamb, AH; Falahi, E; Fan, CC; Fan, H; Fan, M; Fan, MZ; Fan, S; Fan, Y; Fang, CS; Fang, J; Fang, X; Fang, Z; Farmany, A; Farooqi, A; Farouk, HO; Fazelipour, S; Feng, D; Feng, J; Feng, JX; Feng, YL; Ferraz, SL; Ferreira, CR; Figenshau, RS; Finn, AV; Fiseha, T; Fleischer, AS; Fogleman, AD; Fontaine, O; Ford, CR; Fouladvand, F; Four, M; Fousteri, G; Francis, JR; Fraser, JF; Frazier, RP; Fu, H; Fu, P; Fu, YJ; Fujishima, A; Fuster, V; Gabilan, JC; Gagliani, N; Gai, QY; Galán-Arriola, C; Gale, P; Galimova, GR; Galkin, A; Gallo, A; Gallo, AA; Gang, DD; Ganschow, S; Gao, C; Gao, F; Gao, GP; Gao, H; Gao, K; Gao, M; Gao, MY; Gao, P; Gao, R; Gao, S; Gao, WJ; Gao, Y; Garbacz, P; García Ruiz, L; Garcia, EM; Garofoli, F; Gasbarrini, A; Gattinoni, L; Gaudig, M; Gbureck, U; Ge, X; Genko, N; Gentile, GL; George, MW; Gerety, GF; Gestwicki, JE; Geusens, PP; Ghassemi, M; Giardina, JD; Giebultowicz, JM; Gifford, CA; Gijsen, FJH; Gilfillan, R; Gilson, E; Gingl, K; Giuliano, C; Glybochko, P; Goessler, W; Gofflot, S; Golab, J; Goldstein, A; Golebiowski, A; Gómez, L; Gómez-Carballo, J; Gonçalves, PEO; Gonzales, R; Gonzalez-Cotto, M; González-Fernández, D; Gonzalez-Lopez de Turiso, F; Goodman, JM; Govinda Raju, S; Grimm, J; Gross, AJ; Gruenheid, S; Gu, C; Gu, FF; Gu, S; Gu, Z; Guest, RL; Gui, C; Gui, J; Guillem, A; Guo, G; Guo, L; Guo, Q; Guo, S; Guo, SW; Guo, W; Guo, Y; Guo, YG; Guo, Z; Guretzky, JA; Haenggi, M; Hahn, MS; Hakkola, J; Halim, AA; Hampel, D; Han, B; Han, BH; Han, D; Han, G; Han, J; Han, LZ; Han, R; Han, S; Han, X; Han, Z; Handley, MA; Hanke, I; Hannongbua, S; Hao, P; Happ, JT; Hara, M; Haraux, F; Hare, JL; Harper, JD; Hartley, AM; Harvey, E; Hashimoto, K; Hassan, HM; Hautajärvi, H; Hayton, TW; He, C; He, H; He, HJ; He, WP; He, Y; He, Z; Hedrick, V; Heffernan, JK; Hegrová, J; Heidarimoghadam, R; Helms, K; Hengphasatporn, K; Henry, D; Herrmann, TRW; Hesson, T; Himmelbauer, MK; Hindle, A; Hoffmann, R; Hogg, N; Hong, KB; Hong, SK; Honjol, Y; Hood, C; Hsi, RS; Hsu, JL; Hu, B; Hu, BC; Hu, D; Hu, H; Hu, J; Hu, K; Hu, M; Hu, MK; Hu, T; Hu, W; Hu, Y; Hu, Z; Hua, S; Huang, H; Huang, J; Huang, L; Huang, M; Huang, P; Huang, X; Huang, Y; Huang, Z; Hukkanen, J; Hung, MC; Huo, X; Hyötyläinen, T; Ianiro, G; Ibanez, B; Imran, M; Ireland, S; Irwin, MS; Ishiguro, H; Jackowski, K; Jackson, C; Jacob, SI; Jahromy, MH; Jakob, SM; Jang, J; Javvaji, PK; Jefferson, KK; Jena, P; Ji, H; Jiang, F; Jiang, GH; Jiang, H; Jiang, J; Jiang, X; Jiang, Z; Jiao, J; Jiménez, A; Jin, X; Jincai, W; Jintao, X; Jo, K; Jofra, T; Johari, Y; Johnson, ACM; Jones, JH; Josephine Fauci, A; Juhl, AK; Jun, S; Kaiser, RI; Kajioka, J; Kajiyama, H; Kalliyil, A; Kalthur, SG; Kamalanathan, M; Kamaldinov, T; Kanaani, L; Kang, D; Kang, J; Kang, S; Känsäkoski, P; Kaplan, DL; Karwan, M; Kasibhatla, S; Kaur, A; Kawazoe, Y; Ke, C; Keyser, J; Khalique, A; Khan, IT; Kharshoum, RM; Kher, R; Kherani, J; Ki, KK; Kikkawa, F; Kikkawa, R; Kim, BT; Kim, EH; Kim, GA; Kim, GD; Kim, HB; Kim, HG; Kim, JS; Kim, MJ; Kim, SI; Kim, SJ; Kim, Y; King, K; Kinyamu-Akunda, J; Kirkkala, T; Kjaer-Sorensen, K; Kleppinger, EL; Kloner, RA; Klopfenstein, TJ; Knappe, D; Knezevic, P; Kobos, LM; Kohli, M; Kolano, L; Kolodgie, FD; Kolte, AP; Koneru, B; Kong, D; Kong, F; Kong, X; Konggidinata, MI; Köpke, M; Koski, KG; Kotsis, F; Köttgen, A; Kouakou-Kouamé, CA; Kraemer, US; Krane, V; Krehbiel, CR; Krenning, BJ; Kretzschmar, D; Ku, KB; Kubota, Y; Kulich, P; Kumar, NG; Kupiec-Weglinski, JW; Lalani, SS; Lan, X; Landfeldt, E; Langenberg, E; Lapauw, B; Larkin, J; Lassoued, MA; Laukhtina, E; Laura Martinez, J; Laveillé, A; Lavela, P; Law, AD; Lazraq, A; Le Foll, B; Lee, BK; Lee, C; Lee, CS; Lee, EJ; Lee, EY; Lee, G; Lee, HY; Lee, JH; Lee, JJ; Lee, JO; Lee, JS; Lee, R; Lei, H; Lei, P; Lellouche, F; Lennerz, JK; Leong, W; Leslie, I; Lessem, E; Levin, M; Levinger, I; Li, C; Li, CW; Li, CX; Li, CY; Li, D; Li, H; Li, HM; Li, J; Li, L; Li, LM; Li, N; Li, S; Li, W; Li, X; Li, XX; Li, Y; Li, Z; Li, ZL; Li, ZX; Lian, Q; Liang, C; Liang, GH; Liang, H; Liang, J; Liang, X; Liao, CX; Liao, R; Ličbinský, R; Lim, YS; Lima, HK; Lin, JG; Lin, L; Lin, S; Lin, WP; Lin, Z; Liso, M; Liu, BX; Liu, C; Liu, H; Liu, J; Liu, M; Liu, Q; Liu, S; Liu, SF; Liu, SL; Liu, T; Liu, W; Liu, X; Liu, XB; Liu, Y; Liu, YY; Liu, Z; Liu, ZQ; Lobo, M; Loitzenbauer, M; López, F; Lopez, G; López, GJ; Lou, Z; Lu, IC; Lu, J; Lu, M; Lu, W; Lu, X; Lu, Y; Luhovyy, BL; Luna-Abanto, J; Luo, J; Luo, K; Luo, L; Luo, M; Luo, W; Luo, X; Luo, XM; Lv, Y; Lv, YQ; Lyu, HD; Lyu, J; Ma, C; Ma, G; Ma, L; Ma, Q; Ma, X; Ma, Y; Macha, SJ; MacLean, E; Mahalapbutr, P; Maina, T; Malfait, F; Malfertheiner, MV; Malzert-Fréon, A; Mansouri, E; Mao, C; Marcellin, E; Marchiori, PER; Marcotte, DJ; Maréchal, A; Maric, N; Maris, JM; Maron, L; Marti, CN; Martínez-Milla, J; Mateo, J; Mather, K; Mathison, CJN; Matthay, MA; Maxwell, CL; Mazier, D; Mazumder, D; Mazurkiewicz, M; Mazzucchelli, TG; McAuley, DF; Mccoy, K; McVicar, DW; Mebel, AM; Mech, A; Meester, EJ; Meiselbach, H; Melero, I; Ménard, G; Meng, X; Mengya, Y; Merle, G; Meunier, B; Mfarrej, B; Mi, K; Migueliz, I; Mikuška, P; Miladi, K; Miletich, R; Millar, JE; Mills, MR; Milne, R; Minute, L; Misiak, M; Mo, F; Modi, A; Mok, F; Molina, C; Mollen, CJ; Molteni, V; Montalto, M; Montet, D; Monti, MC; Moor, MB; Moravec, P; Morsiani, C; Murillo, E; Murugan, P; Muslem, R; Myers, RK; N'guessan, FK; Nabil, H; Nadal, J; Nadeem, M; Nafady, MM; Nafie, MS; Nair, HP; Nakano, R; Nance, J; Naren, N; Neil, CJ; Nelson, J; Nery, FC; Netsch, C; Nguyen, TH; Ni, L; Ni, YX; Nie, W; Nielsen, LK; Nigam, K; Nikolayev, AA; Nishiyama, M; Niu, LL; Niu, PP; Nock, BA; Noer, PR; Noll, G; Noll, S; Norenberg, JP; Nowicka, J; Nutho, B; O'Connor, M; Obonyo, NG; Ochiai, T; Ochoa, MC; Oh, BL; Oh, S; Olczak, J; Olivares, X; Ommurugan, B; Oosthuizen, MC; Operario, D; Orešič, M; Oshima, K; Otano, I; Ou, Y; Owen, TW; Oxvig, C; Pacey, V; Pai, M; Paik, H; Paiva, R; Palmieri, EM; Palpant, N; Pan, L; Pan, Q; Panahi, S; Pang, B; Pang, ZC; Pannecouque, C; Paris, L; Park, D; Park, DJ; Park, E; Park, EC; Park, IH; Park, JH; Park, JI; Park, S; Passmore, MR; Pattaranggoon, NC; Paun, M; Pedersen, S; Pedron, J; Peng, M; Peng, X; Penzhorn, BL; Pérez-Camargo, D; Perez-Maldonado, R; Pérez-Vicente, C; Pham, TD; Pickering, L; Pickersgill, NA; Pinault, E; Pinotsis, N; Plan, M; Pocino, K; Poh, CL; Pons, EDC; Popoff, MR; Porri, D; Pourmand, A; Pratviel, G; Prudente, DO; Qi, H; Qi, N; Qian, LY; Qiao, L; Qiao, Q; Qin, QP; Qiu, N; Qiu, SW; Qu, F; Quan, M; Quigg, A; Raee, E; Raibaud, P; Ramanitrahasimbola, D; Rapoport, L; Rasby, RJ; Rasoanirina, BNV; Raspini, B; Ratner, JR; Razafindrakoto, Z; Redd, MA; Ren, H; Ren, N; Rey, J; Reynolds, CP; Rich, PR; Richards, CJ; Rigol, M; Rimoldi, S; Robert, P; Rodrigues, AE; Roe, JH; Rohde, S; Rokita, JL; Roland, J; Rombaut, L; Ronkainen, J; Rothenberg, SM; Roy, SC; Ruan, Z; Rucker, PV; Rueda, D; Ruhwald, M; Rungrotmongkol, T; Rupert, AS; Rusjan, P; Ryabov, AD; Rysä, J; Saad, NES; Sabioni, P; Sadow, PM; Sahai, N; Salem, HF; Salinas, B; Salonurmi, T; Samé Guerra, D; Sánchez, J; Sanchez-González, J; Sanmamed, MF; Sansores-Peraza, P; Santoro, JC; Santschi, PH; Saritas, T; Sarkisova, Y; Savolainen, MJ; Scherberich, JE; Schlom, DG; Schmelz, EM; Schmid, MC; Schneider, MP; Schumacher, S; Schwartz, JC; Schwartzer, JJ; Schwehr, K; Schweitzer, DH; Scott, ME; Sedky, NK; See Hoe, L; Sejian, V; Selvaraju, S; Sen, SK; Seo, G; Šerý, O; Settles, JA; Sfar, S; Shaffer, J; Shan, GL; Shang, Q; Shannahan, JH; Shao, B; Shao, H; 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| Hara, K; Haranishi, Y; Terada, T | 1 |
| Lei, Q; Li, G; Li, H; Lv, Z; Wang, Y; Yan, Z; Yi, T | 1 |
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| El Ghaffar, AEA; El-Kowrany, SI; Gamea, GAM; Mady, RF; Shoheib, ZS | 1 |
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| Chen, C; Davis, JR; Di, G; Liao, D; Shi, W; Tang, L; Wang, H; Wu, Z; Zhang, B | 1 |
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| Honda, Y; Kamisato, C; Morishima, Y; Shibano, T | 1 |
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| Cho, SW; Choi, SY; Ha, SC; Han, AR; Kim, DS; Kim, DW; Kim, EA | 1 |
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| Bertram, JE; Gutmann, A; Hurtig, M; Matyas, JR; Randev, J | 1 |
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| Barnes, C; Bergman, J; Ferré, S; Fratta, W; Goldberg, SR; Justinova, Z; Kangas, BD; Mascia, P; Panlilio, LV; Parashos, A; Pistis, M; Redhi, GH; Scherma, M; Schwarcz, R; Secci, ME; Solinas, M; Tanda, G; Wu, HQ; Zara, T | 1 |
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| Dai, B; Fang, B; Gao, W; Hofstetter, WL; Lu, H; Meng, J; Minna, J; Roth, JA; Swisher, SG; Wang, L; Wu, S | 1 |
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| Bajpai, M; Banerjee, A; Gharat, LA; Gudi, GS; Gullapalli, S; Jadhav, S; Kadam, PA; Khairatkar-Joshi, N; Kumar, H; Merugu, RR; More, SV; Narayana, L; Pisal, DV; Raje, FA; Sangana, RR; Voleti, SR | 1 |
| Kinouchi, M; Kuribayashi, N; Miyamoto, Y; Nagai, H; Takamaru, N; Tamatani, T; Uchida, D | 1 |
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| Gao, M; Maixner, DW; Weng, HR | 1 |
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| Baek, SE; Do, BR; Kaengkan, P; Kam, KY; Kang, SG; Kim, JY; Lee, ES | 1 |
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| Chang, PC; Chen, CC; Chen, YW; Jheng, YH; Lin, YF; Tsai, SC; Wang, CY | 1 |
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| Asada, T; Hagiwara, M; Kawamoto, D; Kii, I; Kurihara, T; Miyata, A; Sakurai, E; Tanabe, T; Toyomoto, M; Yoshimura, M | 1 |
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| Bobrov, AG; Burlison, JA; Fetherston, JD; Kirillina, O; Miller, MC; Perry, RD | 1 |
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| Baron, T; Billard, T; Bouillot, C; Chauveau, F; Lancelot, S; Levigoureux, E; Verchere, J; Verdurand, M; Zimmer, L | 1 |
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| Bil, J; Bobrowicz, M; Bojarczuk, K; Dabrowska-Iwanicka, A; Dwojak, M; Efremov, DG; Golab, J; Juszczynski, P; Krol, M; Le Roy, A; Leusen, JH; Miazek, N; Olive, D; Pilch, Z; Podszywalow-Bartnicka, P; Pyrzynska, B; Rygiel, TP; Siernicka, M; Slabicki, M; Syta, A; Winiarska, M; Zagozdzon, A; Zapala, P; Zenz, T | 1 |
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| de Groat, WC; Reese, JN; Rogers, MJ; Roppolo, JR; Schwen, Z; Shen, B; Tai, C; Wang, J; Xiao, Z | 1 |
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| Akashi, H; Castillero, E; George, I; Homma, S; Ji, R; Kennel, PJ; Schulze, PC; Zizola, C | 1 |
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| Burkhardt, R; Ceglarek, U; Nofer, JR; Potì, F; Simoni, M | 1 |
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| Castonguay, A; Chen, Z; Cottet, M; De Koninck, Y; Doyle, T; Egan, TM; Ford, A; Jacobson, KA; Little, JW; Salvemini, D; Symons-Liguori, AM; Tosh, DK; Vanderah, TW | 1 |
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| Gandour-Edwards, R; Holt, R; Rebhun, RB; Shahi, MH; Withers, SS; York, D | 1 |
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| Clark, T; Macauley, MS; Shan, X; Skorobogatko, Y; Vocadlo, DJ; Vosseller, K; Yuzwa, SA | 1 |
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| Duong, LT; Hayami, T; Pickarski, M; Wesolowski, GA; Zhuo, Y | 1 |
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| Ke, YN; Li, AL; Li, JH; Li, XL; Shi, ZX; Wang, Y; Yang, P | 1 |
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| Cen, O; Dargart, JL; Fish, K; Gordon, LI; Longnecker, R | 1 |
| Baumeister, R; Biernat, J; Fatouros, C; Koushika, SP; Mandelkow, E; Mandelkow, EM; Pir, GJ; Schmidt, E | 1 |
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| Adelekun, AE; Hannaway, KE; Horiguchi, M; Jayathilake, K; Meltzer, HY | 1 |
| Danysz, W; Gyertyán, I; Jatzke, C; Kassai, F; Kedves, R; Lendvai, B; Pietraszek, M; Schlumberger, C | 1 |
| Gupta, A; Kalonia, H; Kumar, A; Mishra, J; Sharma, N | 1 |
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| Fu, J; Hu, Y; Liu, L; Yang, X; Zhang, Z | 1 |
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| Adachi, H; Huang, Z; Ishigaki, S; Katsumata, R; Katsuno, M; Kawai, K; Sobue, G; Sone, J; Tanaka, F; Urano, F | 1 |
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| Alonso-Pacho, A; de la Puerta González-Quevedo, C; Fabregate-Fuente, M; Sabán-Ruiz, J | 1 |
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| Benezra, M; Bradbury, MS; Hambardzumyan, D; Holland, EC; Larson, SM; Longo, V; Ozawa, T; Penate-Medina, O; Phillips, E; Pillarsetty, N; Smith-Jones, P; Veach, DR; Zanzonico, PB | 1 |
| de Castro, JP; Kaplan, HJ; Liu, L; McDonald, K; Scott, PA; Tamiya, S; Umazume, K | 1 |
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| Borchelt, DR; Coonfield, M; Copeland, NG; Fromholt, D; Gonzales, V; Jenkins, NA; Wang, J; Xu, G | 1 |
| Aronow, BJ; Bales, KR; DeMattos, RB; Harmony, JA; Holtzman, DM; O'dell, MA; Parsadanian, M; Paul, SM; Taylor, JW | 1 |
| Breidert, T; Callebert, J; Heneka, MT; Hirsch, EC; Landreth, G; Launay, JM | 1 |
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| Bacskai, BJ; Games, D; Hyman, BT; Kajdasz, ST; McLellan, ME; Schenk, D; Seubert, P | 1 |
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| Allen, B; Atzori, C; Craxton, M; Crowther, RA; Emson, PC; Ghetti, B; Goedert, M; Holzer, M; Ingram, E; Jakes, R; Migheli, A; Smith, MJ; Spillantini, MG; Takao, M; Virdee, K; Yoshida, H | 1 |
| Ambalavanan, N; Bulger, A; Chen, YF; Oparil, S; Philips, JB | 1 |
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| Banday, AA; Hussain, T; Lokhandwala, MF; Umrani, DN | 1 |
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| Aburatani, H; Blumberg, RS; Kadowaki, T; Matsuhashi, N; Nagai, R; Nakajima, A; Saubermann, LJ; Terauchi, Y; Wada, K; Zhao, S | 1 |
| Prous, JR; Silvestre, JS; Vázquez, M | 1 |
| Borowski, BJ; Curran, GL; Jack, CR; Macura, SI; Poduslo, JF; Sigurdsson, EM; Wengenack, TM; Wisniewski, T | 1 |
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| Andrén, PE; Arts, J; Gunne, L; Jongsma, M; Klintenberg, R; Wikström, H | 1 |
| Anglard, P; Bonnafous, S; Chavey, C; Mari, B; Monthouel, MN; Tartare-Deckert, S; Van Obberghen, E | 1 |
| Bibby, MC; Bradshaw, TD; Cooper, PA; Double, JA; Farmer, PB; Gaskell, M; Heydon, RT; Leong, CO; Martin, EA; Stevens, MF | 1 |
| Bacskai, BJ; D'Amore, JD; Hyman, BT; Kajdasz, ST; McLellan, ME; Stern, EA | 1 |
| Adams, AD; Berger, JP; Doebber, TW; Hu, Z; Jones, AB; MacNaul, KL; Moller, DE; Santini, C; Yuen, W | 1 |
| Chao, VA; Hornung, D; Taylor, RN; Vigne, JL; Wallwiener, D | 1 |
| Ida, M; Kurosaki, E; Nakano, R; Shibasaki, M; Shikama, H; Shimaya, A; Suzuki, T; Yoshida, S | 1 |
| Bergeron, RJ; Nguyen, JN; Sninsky, CA; Weimar, WR; Wiegand, J | 1 |
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| Bacskai, BJ; Hyman, BT; Kajdasz, ST; McLellan, ME | 1 |
| Gruszka, A; Karasek, M; Kunert-Radek, J; Lawnicka, H; Pawlikowski, M | 1 |
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| Maubach, K | 1 |
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| Flecknell, PA; Roughan, JV | 1 |
| Kutschy, P; Mezencev, R; Mojzis, J; Pilatova, M | 1 |
| Albin, RL; Desmond, TJ; Frey, KA; Kemmerer, ES; Kilbourn, MR | 1 |
| Abrahmsen, LB; Alberts, P; Ashkzari, M; Bergqvist, E; Björkstrand, E; Edling, NH; Engblom, LO; Fiedler, M; Forsgren, M; Klingström, G; Larsson, C; Nilsson, C; Nilsson, CE; Norling, S; Ohman, B; Selen, G | 1 |
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| Barringhaus, KG; Chen, M; Czarnik, AC; Hesselbacher, S; Ley, K; Nadler, J; Phillips, JW; Sanders, JM; Sarembock, IJ; Yang, Z | 1 |
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| Davies, BR; Flecknell, PA; Roughan, JV | 1 |
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| Avery, MA; Benson, SC; Chittiboyina, A; Ellis, CN; Ho, CI; Kurtz, TW; Meingassner, J; Pershadsingh, HA; Varani, J; Venkatraman, MS | 1 |
| Anderson, JJ; Brodkin, J; Chung, J; Cosford, ND; Cramer, M; Huang, D; Jiang, X; Kamenecka, T; Munoz, B; Reyes-Manalo, G; Roppe, JR; Schweiger, EJ; Tehrani, L; Wang, B | 1 |
| Anderson, JJ; Bristow, LJ; Brodkin, J; Busse, CS; Cosford, ND; Tattersall, D; Tehrani, L; Varney, MA; Warren, N | 1 |
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| Barbour, R; Bard, F; Bussière, T; Buttini, M; Games, D; Grajeda, H; Guido, T; Khan, K; Schenk, D; Seubert, P | 1 |
| Choi, IW; Im, MJ; Kim, UH; Lee, HK; Lee, KS; Lee, YC; Lim, JS; Park, HS; Park, KH; Park, SJ | 1 |
| Bauder-Wüst, U; Eisenhut, M; Haberkorn, U; Mier, W; Mohammed, A; Schönsiegel, F; Wolf, M | 1 |
| Borwege, S; Hagner, D; Joyce, JN; Ryoo, H; Woolsey, C | 1 |
| Jayakumar, R; Murali, J; Satheeshkumar, KS | 1 |
| Bales, KR; Costa, DA; Nilsson, LN; Paul, SM; Potter, H | 1 |
| Barrish, JC; Behnia, K; Chen, BC; Chen, P; Das, J; De Fex, HF; Doweyko, AM; Leith, L; McIntyre, KW; Norris, D; Pang, S; Pitt, S; Schieven, GL; Shen, DR; Shuster, DJ; Spergel, SH; Wityak, J; Zhang, R; Zhao, R | 1 |
| Bolger, G; Bousquet, C; Cordingley, MG; Faucher, AM; Garneau, M; Harji, F; Kibler, P; Lapeyre, N; Liuzzi, M; McCollum, RS; Simoneau, B | 1 |
| Chakraborty, G; Ji, ZJ; Sheng, SL; Wang, R; Yang, F; Zhang, JY | 1 |
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| Engelstein, R; Gabizon, R; Greig, NH; Grigoriadis, N; Ovadia, H | 1 |
| Colohan, AR; Yamaguchi, M; Zhang, JH; Zhou, C | 1 |
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| Bronson, JJ; Clark, JM; Connolly, TP; Goodrich, J; Huang, XS; Leet, JE; Pucci, MJ; Regueiro-Ren, A; Springer, DM; Ueda, Y | 1 |
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| Barker, AL; Bates, GP; Beunard, JL; Hockly, E; Holt, K; Lowden, PA; Moffitt, H; Moolman, DL; Revington, AP; Sathasivam, K; Sunshine, S; Tse, J; Wanker, EE; Woodman, B | 1 |
| Blackshaw, LA; Dent, J; Frisby, CL; Jensen, JM; Lehmann, A; Mattsson, JP | 1 |
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| Adriany, G; Borowski, BJ; Curran, GL; Garwood, M; Holasek, SS; Jack, CR; Lin, J; Poduslo, JF; Preboske, GM; Reyes, DA; Wengenack, TM | 1 |
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38 review(s) available for thiazoles and Disease Models, Animal
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
The preclinical profile of lurasidone: clinical relevance for the treatment of schizophrenia.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Depression; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Isoindoles; Lurasidone Hydrochloride; Schizophrenia; Thiazoles | 2013 |
The pharmacokinetics of edoxaban for the prevention and treatment of venous thromboembolism.
Topics: Administration, Oral; Animals; Anticoagulants; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Factor Xa Inhibitors; Fibrinolytic Agents; Humans; Pyridines; Randomized Controlled Trials as Topic; Thiazoles; Venous Thromboembolism | 2014 |
[Pharmacological and clinical profile of acotiamide hydrochloride hydrate (Acofide(®) Tablets 100 mg), a novel therapeutic agent for functional dyspepsia (FD)].
Topics: Administration, Oral; Animals; Benzamides; Cholinesterase Inhibitors; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Disease Models, Animal; Dyspepsia; Gastric Emptying; Gastrointestinal Motility; Humans; Tablets; Thiazoles; Treatment Outcome | 2014 |
Successes and challenges in phenotype-based lead discovery for prion diseases.
Topics: Animals; Brain; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Drug Discovery; Drug Evaluation, Preclinical; Humans; Mice; Prion Diseases; Structure-Activity Relationship; Thiazoles | 2014 |
Edoxaban: a focused review of its clinical pharmacology.
Topics: Administration, Oral; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Evaluation, Preclinical; Drug Interactions; Epidemiologic Methods; Factor Xa Inhibitors; Hemorrhage; Humans; Pyridines; Rabbits; Rats; Thiazoles; Thrombosis | 2014 |
A critical review of neonicotinoid insecticides for developmental neurotoxicity.
Topics: Animals; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Guanidine; Guanidines; Humans; Imidazoles; Insecta; Insecticides; Neonicotinoids; Nitro Compounds; Oxazines; Pyridines; Randomized Controlled Trials as Topic; Receptors, Nicotinic; Reflex, Startle; Risk Assessment; Thiamethoxam; Thiazines; Thiazoles; United States; United States Environmental Protection Agency | 2016 |
Current Research Therapeutic Strategies for Alzheimer's Disease Treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzamides; Benzodioxoles; Brain; Disease Models, Animal; Humans; Mice; Neurons; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fyn; PrPC Proteins; Pyridines; Quinazolines; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Synapses; Thiazoles | 2016 |
Analysis of behavioral constraints and the neuroanatomy of fear to the predator odor trimethylthiazoline: a model for animal phobias.
Topics: Amygdala; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Environment; Fear; Humans; Hypothalamus; Neural Pathways; Odorants; Phobic Disorders; Rats; Thiazoles | 2008 |
A naturally occurring cancer with molecular connectivity to human diseases.
Topics: Animal Diseases; Animals; Antineoplastic Agents; Apoptosis; Brachyura; Disease; Disease Models, Animal; DNA Damage; Drug Evaluation, Preclinical; HSP70 Heat-Shock Proteins; Humans; Molecular Sequence Data; Neoplasms; Pyridines; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53 | 2008 |
Lurasidone: a new drug in development for schizophrenia.
Topics: Animals; Antipsychotic Agents; Bipolar Disorder; Clinical Trials, Phase II as Topic; Disease Models, Animal; Drug Evaluation, Preclinical; Humans; Isoindoles; Lurasidone Hydrochloride; Schizophrenia; Thiazoles | 2009 |
[Do orally active factor Xa (FXa) inhibitors have potential as innovative new anticoagulants? Future perspective from preclinical data].
Topics: Animals; Anticoagulants; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Factor Xa Inhibitors; Humans; Intracranial Thrombosis; Macaca fascicularis; Morpholines; Pyrazoles; Pyridines; Pyridones; Rivaroxaban; Thiazoles; Thiophenes; Venous Thrombosis | 2010 |
[Leukemia: A highly malignant disease].
Topics: Animals; Antineoplastic Agents; Benzamides; Dasatinib; Disease Models, Animal; History, 19th Century; Humans; Imatinib Mesylate; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Philadelphia Chromosome; Piperazines; Pyrimidines; Thiazoles; Tretinoin | 2012 |
Xanthine oxidase inhibitor febuxostat as a novel agent postulated to act against vascular inflammation.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Febuxostat; Heart Failure; Humans; Inflammation; Ischemia; Rabbits; Rats; Renal Insufficiency, Chronic; Thiazoles; Treatment Outcome; Xanthine Oxidase | 2013 |
[Aminoguanidine and other AGE inhibitors].
Topics: Amides; Animals; Arteriosclerosis; Cardiovascular Diseases; Cataract; Clinical Trials as Topic; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Retinopathy; Disease Models, Animal; Drug Design; Glycation End Products, Advanced; Guanidines; Humans; Hydrazines; Hypoglycemic Agents; Thiadiazoles; Thiazoles; Thiazolidines | 2002 |
[OPB-9195].
Topics: Animals; Diabetic Angiopathies; Disease Models, Animal; Drug Design; Glycation End Products, Advanced; Guanidines; Humans; Hypoglycemic Agents; Thiadiazoles; Thiazoles; Thiazolidines | 2002 |
Dopamine agonists and neuroprotection in Parkinson's disease.
Topics: Animals; Antioxidants; Benzothiazoles; Disease Models, Animal; Dopamine Agonists; Environmental Exposure; Humans; Neuroprotective Agents; Neurotoxins; Parkinson Disease; Parkinsonian Disorders; Pramipexole; Thiazoles | 2002 |
Experimental approaches to study PPAR gamma agonists as antidiabetic drugs.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Hypoglycemic Agents; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
GABA(A) receptor subtype selective cognition enhancers.
Topics: Alzheimer Disease; Animals; Benzodiazepines; Cognition; Cognition Disorders; Disease Models, Animal; GABA Agonists; Haplorhini; Hippocampus; Humans; Mice; Mice, Transgenic; Receptors, GABA-A; Thiazoles; Thiophenes | 2003 |
[Hypertension and insulin resistance in obese type 2 diabetic Wistar fatty rat].
Topics: Animals; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Hyperinsulinism; Hypertension; Hypoglycemic Agents; Insulin Resistance; Obesity; Pioglitazone; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones | 2003 |
Antiproliferative and cancer chemopreventive activity of phytoalexins: focus on indole phytoalexins from crucifers.
Topics: Animals; Anticarcinogenic Agents; Brassicaceae; Chemoprevention; Disease Models, Animal; Humans; Indoles; Neoplasms, Experimental; Phytoalexins; Plant Extracts; Sesquiterpenes; Spiro Compounds; Terpenes; Thiazoles; Thiocarbamates | 2003 |
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Humans; Memory Disorders; Mice; Muscarinic Agonists; Oxidative Stress; Piperidines; Quinuclidines; Receptor, Muscarinic M1; Spiro Compounds; tau Proteins; Thiazoles; Thiophenes | 2003 |
A review of the neuroprotective properties of the 5-HT1A receptor agonist repinotan HCl (BAYx3702) in ischemic stroke.
Topics: Animals; Benzopyrans; Disease Models, Animal; Glutamic Acid; Humans; Models, Biological; Nerve Growth Factors; Neuroprotective Agents; Piperazines; Pyridines; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Serotonin 5-HT1 Receptor Agonists; Signal Transduction; Stroke; Thiazoles | 2005 |
Pharmacological properties of BN82451: a novel multitargeting neuroprotective agent.
Topics: Animals; Disease Models, Animal; Nervous System Diseases; Neuroprotective Agents; Phenols; Thiazoles | 2007 |
Pharmacology of meloxicam, a new non-steroidal anti-inflammatory drug with an improved safety profile through preferential inhibition of COX-2.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Tolerance; Humans; Inflammation; Meloxicam; Mice; Rats; Stomach Ulcer; Thiazines; Thiazoles | 1996 |
Sodium and potassium channel modulators: their role in neuroprotection.
Topics: Animals; Benzeneacetamides; Cell Survival; Disease Models, Animal; Lamotrigine; Neurons; Neuroprotective Agents; Piperazines; Piperidines; Potassium Channels; Pyrimidines; Riluzole; Sodium Channels; Thiazoles; Triazines | 1997 |
The rationale for new therapies in acute ischaemic stroke.
Topics: Cerebrovascular Disorders; Disease Models, Animal; Humans; Neuroprotective Agents; Piperidines; Plasminogen Activators; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Thiazoles; Thrombolytic Therapy; Tissue Plasminogen Activator | 1996 |
[Troglitazone: its pharmacology and mechanism of action].
Topics: Animals; Chromans; Diabetes Mellitus; Disease Models, Animal; Glycogen; Glycolysis; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Liver; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
[Preclinical studies of pioglitazone (AD-4833)].
Topics: Animals; Diabetes Mellitus; Disease Models, Animal; Glycogen; Glycolysis; Hypoglycemic Agents; Insulin Resistance; Liver; Pioglitazone; Thiazoles; Thiazolidinediones | 1997 |
Potential role of 5-HT2 and D2 receptor interaction in the atypical antipsychotic action of the novel succimide derivative, perospirone.
Topics: Animals; Antipsychotic Agents; Corpus Striatum; Disease Models, Animal; Dopamine Antagonists; Gene Expression Regulation; Indoles; Isoindoles; Mood Disorders; Rats; Receptors, Dopamine D2; Receptors, Serotonin; Serotonin Antagonists; Thiazoles | 1997 |
[Hypoglycemic agents to improve insulin resistance].
Topics: Adipocytes; Animals; Cell Differentiation; Chromans; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Hyperglycemia; Hyperinsulinism; Hyperlipidemias; Hypoglycemic Agents; Insulin Resistance; Obesity; Pioglitazone; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
Therapeutic strategies in Alzheimer's disease: M1 muscarinic agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Carbamates; Cheirogaleidae; Disease Models, Animal; Humans; Muscarinic Agonists; Neuroprotective Agents; Phenylcarbamates; Piperidines; Receptor, Muscarinic M1; Receptors, Muscarinic; Rivastigmine; Signal Transduction; tau Proteins; Thiazoles | 2000 |
Toxicological consequences of altered peroxisome proliferator-activated receptor gamma (PPARgamma) expression in the liver: insights from models of obesity and type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Liver; Mice; Obesity; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Pharmacological treatment of insulin resistance in obesity.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Hypoglycemic Agents; Insulin Resistance; Obesity; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2001 |
PPAR(gamma) and glucose homeostasis.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Regulation; Homeostasis; Humans; Hypoglycemic Agents; Insulin; Mice; Mice, Knockout; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic | 2002 |
Experimental chemotherapy of lymphatic filariasis. A review.
Topics: Animals; Cats; Disease Models, Animal; Dogs; Elephantiasis, Filarial; Filaricides; Humans; Ivermectin; Organic Chemicals; Piperazines; Thiazoles | 1991 |
Developments in non-anticholinergic anti-ulcer agents.
Topics: Anesthetics, Local; Animals; Antimalarials; Carbonic Anhydrase Inhibitors; Carrageenan; Denervation; Disease Models, Animal; Dogs; Fatty Acids; Ganglionic Blockers; Gastric Juice; Glycyrrhiza; Guinea Pigs; Hydrogen-Ion Concentration; Pectins; Pepsin A; Peptic Ulcer; Phenylacetates; Plants, Medicinal; Promethazine; Propylamines; Pylorus; Pyridines; Quaternary Ammonium Compounds; Rats; Stomach; Thiazoles; Tranquilizing Agents; Wound Healing | 1970 |
7 trial(s) available for thiazoles and Disease Models, Animal
| Article | Year |
|---|---|
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
Targeted therapy in patients with PIK3CA-related overgrowth syndrome.
Topics: Adult; Animals; Child; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Female; Heart Failure; HeLa Cells; Humans; Lipoma; Male; Mice; Molecular Targeted Therapy; Musculoskeletal Abnormalities; Nevus; Phenotype; Scoliosis; Sirolimus; Syndrome; Thiazoles; Vascular Malformations; Vascular Neoplasms | 2018 |
A dietary regimen of caloric restriction or pharmacological activation of SIRT1 to delay the onset of neurodegeneration.
Topics: Analysis of Variance; Animals; Atrophy; Brain; Caloric Restriction; Case-Control Studies; Cognition Disorders; Cyclin-Dependent Kinase 5; Disease Models, Animal; Double-Blind Method; Excitatory Postsynaptic Potentials; Female; Green Fluorescent Proteins; Immunoprecipitation; In Vitro Techniques; Long-Term Potentiation; Male; Memory Disorders; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Nerve Tissue Proteins; Neurodegenerative Diseases; Phosphopyruvate Hydratase; Phosphotransferases; Piperidines; Silver Staining; Sirtuin 1; Synapses; Thiazoles; Tumor Suppressor Protein p53; Vitamin E | 2013 |
IAP antagonists induce anti-tumor immunity in multiple myeloma.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Cell Line, Tumor; Cyclophosphamide; Dendritic Cells; Disease Models, Animal; Female; Gene Expression; Humans; Inhibitor of Apoptosis Proteins; Interferon Type I; Macrophages; Male; Mice; Mice, Transgenic; Middle Aged; Multiple Myeloma; Neoplasm Recurrence, Local; Phagocytosis; Thiazoles | 2016 |
Role of AMP kinase and PPARdelta in the regulation of lipid and glucose metabolism in human skeletal muscle.
Topics: Adenylate Kinase; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Gene Expression Regulation; Glucose; Humans; Insulin; Lipid Metabolism; Muscle Cells; Muscle, Skeletal; Oxidation-Reduction; Phosphorylation; PPAR delta; RNA, Small Interfering; Thiazoles | 2007 |
Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia.
Topics: Adolescent; Adult; Aged; Animals; Blood-Brain Barrier; Central Nervous System Neoplasms; Child; Cytogenetic Analysis; Dasatinib; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Monitoring; Female; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Remission Induction; Spinal Puncture; Survival Rate; Thiazoles; Treatment Outcome; Tumor Burden | 2008 |
837 other study(ies) available for thiazoles and Disease Models, Animal
| Article | Year |
|---|---|
Topics: Aldehyde Dehydrogenase; Animals; Benomyl; Disease Models, Animal; Dopamine; Indoles; Parkinson Disease; Thiazoles; Zebrafish | 2022 |
Nitazoxanide induced myocardial injury in zebrafish embryos by activating oxidative stress response.
Topics: Animals; Animals, Genetically Modified; Apoptosis; Cardiotoxicity; Computational Biology; Disease Models, Animal; Disease Susceptibility; Embryo, Nonmammalian; Gene Expression Profiling; Gene Ontology; Heart Injuries; Myocytes, Cardiac; Nitro Compounds; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Thiazoles; Zebrafish | 2021 |
Treatment with Edoxaban Attenuates Acute Stroke Severity in Mice by Reducing Blood-Brain Barrier Damage and Inflammation.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Humans; Infarction, Middle Cerebral Artery; Inflammation; Mice; Pyridines; Severity of Illness Index; Stroke; Thiazoles | 2021 |
Alpelisib combination treatment as novel targeted therapy against hepatocellular carcinoma.
Topics: Anilides; Animals; Benzoxazoles; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Female; Humans; Liver Neoplasms; MAP Kinase Signaling System; Mice; Molecular Targeted Therapy; Mutation; Piperazines; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; PTEN Phosphohydrolase; Pyridines; Pyrimidines; Thiazoles; Treatment Outcome; Tumor Burden | 2021 |
Novel NFκB Inhibitor SC75741 Mitigates Chondrocyte Degradation and Prevents Activated Fibroblast Transformation by Modulating miR-21/GDF-5/SOX5 Signaling.
Topics: Animals; Benzimidazoles; Cell Differentiation; Chondrocytes; Collagen Type IV; Disease Models, Animal; Female; Fibroblasts; Gene Expression Regulation; Growth Differentiation Factor 5; Humans; Interleukin-1beta; MicroRNAs; NF-kappa B; Osteoarthritis; Piperidines; Pyrimidines; Rats, Wistar; Signal Transduction; SOXD Transcription Factors; Synovial Membrane; Thiazoles | 2021 |
O-GlcNAcase inhibitor has protective effects in intracerebral hemorrhage by suppressing the inflammatory response.
Topics: Animals; B-Lymphocytes; Behavior, Animal; beta-N-Acetylhexosaminidases; Blood-Brain Barrier; Brain Edema; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cerebral Hemorrhage; Cytokines; Disease Models, Animal; Hematoma; Killer Cells, Natural; Mice; Microglia; Neuroinflammatory Diseases; Neuroprotective Agents; Neutrophils; Protein Processing, Post-Translational; Pyrans; Rotarod Performance Test; Thiazoles | 2021 |
Antagonizing the CX3CR1 Receptor Markedly Reduces Development of Cardiac Hypertrophy After Transverse Aortic Constriction in Mice.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Chemokine CX3CL1; Collagen Type I, alpha 1 Chain; Constriction; CX3C Chemokine Receptor 1; Disease Models, Animal; Fibrosis; Hypertrophy, Left Ventricular; Male; Mice, Inbred C57BL; Myocytes, Cardiac; Natriuretic Peptide, Brain; Pyrimidines; Signal Transduction; Thiazoles; Time Factors; Transforming Growth Factor beta1; Ventricular Function, Left; Ventricular Remodeling | 2021 |
Target enzymes in oxaliplatin-induced peripheral neuropathy in Swiss mice: A new acetylcholinesterase inhibitor as therapeutic strategy.
Topics: Adenosine Triphosphatases; Analgesics; Animals; Anxiety; Benzoates; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Cognitive Dysfunction; Disease Models, Animal; Female; Hippocampus; Indoles; Male; Mice; Oxaliplatin; Oxidative Stress; Peripheral Nervous System Diseases; Spinal Cord; Thiadiazoles; Thiazoles | 2022 |
Effect of NK-5962 on Gene Expression Profiling of Retina in a Rat Model of Retinitis Pigmentosa.
Topics: Aniline Compounds; Animals; Apoptosis; Computational Biology; Disease Models, Animal; Eye Proteins; Gene Expression Regulation; Gene Ontology; Intravitreal Injections; Male; Nerve Growth Factors; Rats; Retina; Retinitis Pigmentosa; RNA-Seq; Serpins; Thiazoles; Visual Prosthesis | 2021 |
Platonin protects against cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasomes via BNIP3/LC3 signaling mediated autophagy.
Topics: Animals; Autophagy; Disease Models, Animal; Inflammasomes; Membrane Proteins; Microtubule-Associated Proteins; Mitochondrial Proteins; Neuroprotective Agents; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Reperfusion Injury; Thiazoles | 2022 |
MTEP, a Selective mGluR5 Antagonist, Had a Neuroprotective Effect but Did Not Prevent the Development of Spontaneous Recurrent Seizures and Behavioral Comorbidities in the Rat Lithium-Pilocarpine Model of Epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Epilepsy; Hippocampus; Lithium; Male; Neurons; Neuroprotective Agents; Pilocarpine; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Seizures; Thiazoles | 2022 |
Cold Exposure Drives Weight Gain and Adiposity following Chronic Suppression of Brown Adipose Tissue.
Topics: Acetanilides; Adipose Tissue, Brown; Animals; Cold Temperature; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Male; Proteomics; Rats; Subcutaneous Fat; Thermogenesis; Thiazoles; Uncoupling Protein 1; Weight Gain | 2022 |
Impact of Notch3 Activation on Aortic Aneurysm Development in Marfan Syndrome.
Topics: Animals; Aorta; Aortic Aneurysm; Diamines; Disease Models, Animal; Elastin; Fibrillin-1; Humans; Marfan Syndrome; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Molecular Targeted Therapy; Myocytes, Smooth Muscle; Receptor, Notch3; Thiazoles | 2022 |
Factor Xa inhibitor, edoxaban ameliorates renal injury after subtotal nephrectomy by reducing epithelial-mesenchymal transition and inflammatory response.
Topics: Animals; Atrial Fibrillation; Disease Models, Animal; Epithelial-Mesenchymal Transition; Factor Xa Inhibitors; Fibrosis; Inflammation Mediators; Kidney; Mice; Nephrectomy; Pyridines; Renal Insufficiency, Chronic; Thiazoles | 2022 |
Continuous administration of mirabegron has advantages in inhibition of central sensitization compared with short-term treatment cessation in a mouse model of overactive bladder.
Topics: Acetanilides; Animals; Central Nervous System Sensitization; Disease Models, Animal; Female; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazoles; Urinary Bladder, Overactive | 2022 |
PPARβ/δ activation protects against hepatic ischaemia-reperfusion injury.
Topics: Animals; Disease Models, Animal; Inflammation; Ischemia; Liver; Mice; NF-kappa B; PPAR delta; PPAR-beta; Reperfusion Injury; Thiazoles | 2023 |
Exposure to PM
Topics: Animals; Asthma; Cholesterol, HDL; Cholesterol, LDL; Diamines; Disease Models, Animal; Dyslipidemias; Female; Gene Expression; Lipid Metabolism; Male; Ovalbumin; Particulate Matter; Rats; Rats, Wistar; Signal Transduction; Thiazoles; Transcription Factor HES-1; Triglycerides | 2019 |
Further characterization of a novel EP2 and EP3 receptor dual agonist, ONO-8055, on lower urinary tract function in normal and lumbar canal stenosis rats.
Topics: Animals; Disease Models, Animal; Female; Lumbar Vertebrae; Rats; Rats, Wistar; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Spinal Stenosis; Thiazoles; Urethra; Urinary Bladder | 2020 |
MicroRNA profiling identifies a novel compound with antidepressant properties.
Topics: Animals; Antidepressive Agents; Brain Injuries, Traumatic; Computational Biology; Depression; Disease Models, Animal; Estradiol; Fluoxetine; Gene Expression Regulation; Hippocampus; Humans; Imipramine; MicroRNAs; Rats; Sertraline; Sulfonamides; Thiazoles | 2019 |
Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cyclohexanes; Disease Models, Animal; Humans; Magnetic Resonance Imaging; Mice; Neoplasms; Positron-Emission Tomography; Pyrroles; Thiazoles; Xenograft Model Antitumor Assays | 2019 |
Transcriptional inhibition by CDK7/9 inhibitor SNS-032 abrogates oncogene addiction and reduces liver metastasis in uveal melanoma.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Cycle Proteins; Cell Line, Tumor; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Kruppel-Like Factor 4; Liver Neoplasms; Male; Melanoma; Mice; Oncogene Addiction; Oxazoles; Signal Transduction; Thiazoles; Transcription Factors; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2019 |
Allyl isothiocyanate may reverse the expression of MRP1 in COPD rats via the Notch1 signaling pathway.
Topics: Animals; Cell Line; Diamines; Disease Models, Animal; Down-Regulation; Epithelial Cells; Humans; Isothiocyanates; Lipopolysaccharides; Lung; Male; Multidrug Resistance-Associated Proteins; Pulmonary Disease, Chronic Obstructive; Rats; Receptor, Notch1; Signal Transduction; Thiazoles; Transcription Factor HES-1; Up-Regulation | 2019 |
The effect of mirabegron on bladder blood flow in a rat model of bladder outlet obstruction.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Disease Models, Animal; Female; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Thiazoles; Urinary Bladder; Urinary Bladder Neck Obstruction | 2020 |
Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis.
Topics: Animals; Cell Line; Diamines; Disease Models, Animal; Epithelial Cells; Fibrosis; Humans; Male; Myofibroblasts; Phenotype; Rats; Rats, Sprague-Dawley; Receptor, Notch1; Signal Transduction; Thiazoles | 2019 |
Effects of combined treatment with fesoterodine and mirabegron in a pelvic congestion rat model: Results from in vitro and in vivo functional studies.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Benzhydryl Compounds; Cresols; Disease Models, Animal; Drug Monitoring; Drug Therapy, Combination; Female; Muscarinic Antagonists; Rats; Rats, Sprague-Dawley; Thiazoles; Treatment Outcome; Urinary Bladder, Overactive | 2020 |
Duloxetine reverses the symptoms of overactive bladder co-existing with depression via the central pathways.
Topics: Acetanilides; Animals; Antidepressive Agents; Behavior, Animal; Corticosterone; Depression; Disease Models, Animal; Duloxetine Hydrochloride; Female; Locomotion; Rats; Rats, Wistar; Signal Transduction; Solifenacin Succinate; Thiazoles; Treatment Outcome; Urinary Bladder, Overactive; Urological Agents | 2020 |
Elevated Type 1 Metabotropic Glutamate Receptor Availability in a Mouse Model of Huntington's Disease: a Longitudinal PET Study.
Topics: Animals; Benzamides; Disease Models, Animal; Huntington Disease; Mice, Inbred C57BL; Positron-Emission Tomography; Receptors, Metabotropic Glutamate; Thiazoles | 2020 |
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.
Topics: Allosteric Regulation; Alzheimer Disease; Animals; Behavior, Animal; Brain; CHO Cells; Cognition; Cricetulus; Cyclopropanes; Disease Models, Animal; Epilepsies, Myoclonic; Humans; Male; Mice; Mice, Inbred C57BL; Nitriles; Pyrazoles; Receptors, N-Methyl-D-Aspartate; Thiazoles | 2020 |
Antifilarial effect of nanocomposite of silver nanoparticles with nitazoxanide against the microfilariae of Setaria cervi-infected albino rats.
Topics: Animals; Diethylcarbamazine; Disease Models, Animal; Drug Compounding; Drug Synergism; Filaricides; Host-Parasite Interactions; Male; Metal Nanoparticles; Nanocomposites; Nitro Compounds; Rats; Setaria Nematode; Setariasis; Silver; Thiazoles | 2020 |
The Effects of RKI-1447 in a Mouse Model of Nonalcoholic Fatty Liver Disease Induced by a High-Fat Diet and in HepG2 Human Hepatocellular Carcinoma Cells Treated with Oleic Acid.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Cholesterol; Diet, High-Fat; Disease Models, Animal; Glucose Tolerance Test; Hep G2 Cells; Humans; Insulin Resistance; Interleukin-6; Liver; Liver Neoplasms; Male; Malondialdehyde; Mice, Inbred ICR; Models, Biological; Non-alcoholic Fatty Liver Disease; Oleic Acid; Oxidative Stress; rhoA GTP-Binding Protein; Signal Transduction; Superoxide Dismutase; Thiazoles; Triglycerides; Tumor Necrosis Factor-alpha; Urea | 2020 |
Combination drug therapy against OAB normalizes micturition parameters and increases the release of nitric oxide during chemically induced cystitis.
Topics: Acetanilides; Animals; Cyclophosphamide; Cystitis; Disease Models, Animal; Drug Therapy, Combination; Male; Nitric Oxide; Random Allocation; Rats; Rats, Sprague-Dawley; Thiazoles; Tolterodine Tartrate; Treatment Outcome; Urinary Bladder, Overactive | 2020 |
Effects of edoxaban and warfarin on vascular remodeling: Atherosclerotic plaque progression and collateral artery growth.
Topics: Animals; Anticoagulants; Atherosclerosis; Collateral Circulation; Disease Models, Animal; Factor Xa Inhibitors; Fibrosis; Hindlimb; Ischemia; Mice, Inbred C57BL; Mice, Knockout, ApoE; Muscle, Skeletal; Neovascularization, Physiologic; Plaque, Atherosclerotic; Pyridines; Thiazoles; Vascular Remodeling; Warfarin | 2020 |
α2-Adrenergic Receptor in Liver Fibrosis: Implications for the Adrenoblocker Mesedin.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Dioxanes; Disease Models, Animal; Female; Humans; Liver Cirrhosis; Mice; Receptors, Adrenergic, alpha-2; Thiazoles | 2020 |
Histopathologic evaluation of experimental murine neurocysticercosis after treatment with albendazole/nitazoxanide combination.
Topics: Albendazole; Animals; Anticestodal Agents; Disease Models, Animal; Drug Combinations; Female; Mice; Mice, Inbred BALB C; Neurocysticercosis; Nitro Compounds; Taenia; Thiazoles | 2020 |
Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages
Topics: Animals; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Fatty Liver; Fenofibrate; Hypolipidemic Agents; Liver; Liver Cirrhosis; Macrophages; Male; Mice; Peroxisome Proliferator-Activated Receptors; Thiazoles | 2020 |
Antihyperalgesic effects of intrathecal perospirone in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Isoindoles; Male; Neuralgia; Pain Measurement; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Rotarod Performance Test; Serotonin 5-HT1 Receptor Antagonists; Signal Transduction; Thiazoles | 2020 |
Ubiquitin C-terminal hydrolase L1 (UCHL1) regulates post-myocardial infarction cardiac fibrosis through glucose-regulated protein of 78 kDa (GRP78).
Topics: Animals; Disease Models, Animal; Endoplasmic Reticulum Chaperone BiP; Fibrosis; Heat-Shock Proteins; Mice; Myocardial Infarction; Myofibroblasts; Signal Transduction; Sulfonamides; Thiazoles; Transforming Growth Factor beta1; Ubiquitin Thiolesterase; Up-Regulation | 2020 |
Effects of Chronic Masitinib Treatment in APPswe/PSEN1dE9 Transgenic Mice Modeling Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzamides; Cognition; Disease Models, Animal; Male; Mice, Transgenic; Piperidines; Presenilin-1; Pyridines; Synapses; Thiazoles | 2020 |
Diet-induced dyslipidemia induces metabolic and migratory adaptations in regulatory T cells.
Topics: Animals; Atherosclerosis; Cell Movement; Cells, Cultured; Coculture Techniques; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Energy Metabolism; Fatty Acids; Inflammation; Inflammation Mediators; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice, Knockout, ApoE; Oxidation-Reduction; Phenotype; Plaque, Atherosclerotic; PPAR gamma; Receptors, LDL; Signal Transduction; T-Lymphocytes, Regulatory; Thiazoles | 2021 |
Effect of murine double-minute 2 inhibitors in preclinical models of advanced clear cell carcinomas originating from ovaries and kidneys.
Topics: Adenocarcinoma, Clear Cell; Animals; Apoptosis; Carcinoma, Renal Cell; Cell Cycle; Cell Proliferation; Disease Models, Animal; Everolimus; Female; Heterografts; Humans; Imidazoles; Kidney; Mice; Ovarian Neoplasms; Peritonitis; Platelet Endothelial Cell Adhesion Molecule-1; Proto-Oncogene Proteins c-mdm2; Thiazoles; TOR Serine-Threonine Kinases | 2020 |
Peroxisome Proliferator-Activated Receptor Beta/Delta Agonist Suppresses Inflammation and Promotes Neovascularization.
Topics: Animals; Corneal Injuries; Disease Models, Animal; Gene Expression Regulation; Inflammation; Interleukin-1beta; Interleukin-6; Male; Neovascularization, Physiologic; PPAR delta; PPAR-beta; Rats; Rats, Wistar; Thiazoles; Vascular Endothelial Growth Factor A | 2020 |
Activating PIK3CA mutation promotes adipogenesis of adipose-derived stem cells in macrodactyly via up-regulation of E2F1.
Topics: Adipocytes; Adipogenesis; Adipose Tissue; Animals; Cell Differentiation; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; E2F1 Transcription Factor; Female; Fingers; Gain of Function Mutation; Gene Knockdown Techniques; Humans; Hypertrophy; Limb Deformities, Congenital; Mice, Nude; Mutation; Stem Cells; Thiazoles; Up-Regulation | 2020 |
Synthesis and evaluations of selective COX-2 inhibitory effects: Benzo[d]thiazol analogs.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Design; Edema; Mice; Structure-Activity Relationship; Thiazoles | 2020 |
ZHX2 inhibits SREBP1c-mediated de novo lipogenesis in hepatocellular carcinoma via miR-24-3p.
Topics: Adult; Aged; Animals; Carcinogenesis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Hepatocytes; Homeodomain Proteins; Humans; Lipogenesis; Liver Neoplasms; Male; Mice; Mice, Knockout; MicroRNAs; Middle Aged; Pyridines; Sterol Regulatory Element Binding Protein 1; Thiazoles; Transcription Factors; Triglycerides | 2020 |
LIMK1/2 in the mPFC Plays a Role in Chronic Stress-Induced Depressive-Like Effects in Mice.
Topics: Animals; Behavior, Animal; Chronic Disease; Depression; Disease Models, Animal; Fluoxetine; Lim Kinases; Male; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Protein Kinase Inhibitors; Pyrazoles; Restraint, Physical; Selective Serotonin Reuptake Inhibitors; Social Defeat; Stress, Psychological; Thiazoles | 2020 |
Novel thiazole-pyrazolone hybrids as potent ACE inhibitors and their cardioprotective effect on isoproterenol-induced myocardial infarction.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cytokines; Disease Models, Animal; Drug Design; Inflammation Mediators; Isoproterenol; Male; Mitochondria, Heart; Myocardial Infarction; Myocytes, Cardiac; Oxidative Stress; Pyrazolones; Rats, Sprague-Dawley; Thiazoles | 2020 |
Aryl Hydrocarbon Receptor Activity in Hepatocytes Sensitizes to Hyperacute Acetaminophen-Induced Hepatotoxicity in Mice.
Topics: Acetaminophen; Animals; Basic Helix-Loop-Helix Transcription Factors; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Female; Hepatocytes; Humans; Indoles; Liver; Liver Failure, Acute; Male; Mice; Mice, Knockout; Receptors, Aryl Hydrocarbon; Thiazoles | 2021 |
Exploring the Therapeutic Efficacy of Zingerone Nanoparticles in Treating Biofilm-Associated Pyelonephritis Caused by Pseudomonas aeruginosa in the Murine Model.
Topics: Animals; Biofilms; Disease Models, Animal; Guaiacol; HEK293 Cells; Humans; Inflammation; Malondialdehyde; Mice; Microscopy, Electron, Scanning; Nanoparticles; Peroxidase; Phagocytosis; Pseudomonas aeruginosa; Pseudomonas Infections; Pyelonephritis; Stem Cells; Tetrazolium Salts; Thiazoles | 2020 |
Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.
Topics: Animals; Arthritis, Rheumatoid; Biomarkers; Cell Differentiation; Cyclopropanes; Disease Models, Animal; Gene Expression Profiling; Glycolysis; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Immunophenotyping; Lymphocyte Activation; Mice; Mice, Transgenic; Pyrrolidines; Receptors, Adiponectin; Th17 Cells; Thiazoles | 2020 |
AMP-independent activator of AMPK for treatment of mitochondrial disorders.
Topics: Allosteric Regulation; AMP-Activated Protein Kinases; Animals; Biphenyl Compounds; Cell Respiration; Cell Survival; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Fibroblasts; Humans; meta-Aminobenzoates; Mice; Mitochondrial Diseases; Oxidative Stress; Oxygen Consumption; Pyrimidines; Pyrones; Thiazoles; Thiophenes | 2020 |
Discovery of thienothiazolocarboxamide analogues as novel anti-tubercular agent.
Topics: Amides; Animals; Antitubercular Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Stability; Female; Half-Life; Humans; Mice; Mice, Inbred BALB C; Microsomes; Mycobacterium tuberculosis; Structure-Activity Relationship; Thiazoles; Tuberculosis | 2020 |
Gastrodin Regulates the Notch Signaling Pathway and Sirt3 in Activated Microglia in Cerebral Hypoxic-Ischemia Neonatal Rats and in Activated BV-2 Microglia.
Topics: Animals; Animals, Newborn; Benzyl Alcohols; Carotid Artery, Common; Cells, Cultured; Cerebral Cortex; Corpus Callosum; Diamines; Disease Models, Animal; Drug Synergism; Gene Expression Regulation; Glucosides; Hypoxia-Ischemia, Brain; Ligation; Lipopolysaccharides; Microglia; Neuroinflammatory Diseases; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Notch1; Signal Transduction; Sirtuins; Thiazoles; Tumor Necrosis Factor-alpha | 2021 |
SP6616 as a Kv2.1 inhibitor efficiently ameliorates peripheral neuropathy in diabetic mice.
Topics: Animals; Apoptosis; Biomarkers; Calcium; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Ganglia, Spinal; Gene Expression Regulation; Immunohistochemistry; Male; Membrane Potential, Mitochondrial; Mice; Mitochondria; Neurites; Neurons; Protein Binding; Pyrimidines; Shab Potassium Channels; Signal Transduction; Thiazoles | 2020 |
Major role of iron uptake systems in the intrinsic extra-intestinal virulence of the genus Escherichia revealed by a genome-wide association study.
Topics: Animals; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Genetic Variation; Genome-Wide Association Study; Genomic Islands; Humans; Iron; Mice; Phenols; Phylogeny; Sepsis; Siderophores; Thiazoles; Virulence | 2020 |
Role of β
Topics: Acetanilides; Adrenergic beta-1 Receptor Agonists; Adrenergic beta-3 Receptor Agonists; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Capillary Permeability; Disease Models, Animal; Isoproterenol; Lung; Nebivolol; Propranolol; Pulmonary Circulation; Pulmonary Embolism; Rabbits; Receptors, Adrenergic, beta; Thiazoles; Vascular Resistance | 2020 |
Late intervention in the remnant kidney model attenuates proteinuria but not glomerular filtration rate decline.
Topics: Angiotensin-Converting Enzyme Inhibitors; Anilides; Animals; Disease Models, Animal; Disease Progression; Enalapril; Glomerular Filtration Rate; Hypertension; Kidney; Nephrectomy; Postoperative Complications; Proteinuria; Rats; Renal Insufficiency, Chronic; Sirtuin 1; Thiazoles | 2021 |
The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome.
Topics: Amyloid beta-Protein Precursor; Animals; beta-N-Acetylhexosaminidases; Blotting, Western; Brain; Disease Models, Animal; Down Syndrome; Female; Fluorescent Antibody Technique; Immunoprecipitation; Male; Mice; N-Acetylglucosaminyltransferases; Pyrans; Real-Time Polymerase Chain Reaction; tau Proteins; Thiazoles | 2021 |
Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.
Topics: Algorithms; Animals; Aortic Valve; Aortic Valve Disease; Aortic Valve Stenosis; Calcinosis; Disease Models, Animal; Drug Discovery; Drug Evaluation, Preclinical; Gene Expression Regulation; Gene Regulatory Networks; Haploinsufficiency; Humans; Induced Pluripotent Stem Cells; Machine Learning; Mice, Inbred C57BL; Nitriles; Receptor, Notch1; RNA-Seq; Small Molecule Libraries; Thiazoles | 2021 |
Increased alcohol self-administration following exposure to the predator odor TMT in active coping female rats.
Topics: Adaptation, Psychological; Alcohol Drinking; Alcoholism; Animals; Behavior, Animal; Disease Models, Animal; Female; Individuality; Male; Odorants; Rats; Rats, Long-Evans; Stress Disorders, Post-Traumatic; Stress, Psychological; Thiazoles | 2021 |
Double-Stranded RNA Dependent Kinase R Regulates Antibacterial Immunity in Sepsis.
Topics: Animals; Cecum; Cells, Cultured; Disease Models, Animal; eIF-2 Kinase; Escherichia coli; Escherichia coli Infections; Humans; Immunity, Innate; Indoles; Interleukin-1beta; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Double-Stranded; Signal Transduction; Thiazoles | 2021 |
The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia.
Topics: Animals; Benzamides; Benzyl Compounds; Disease Models, Animal; Dyspepsia; Gastrointestinal Motility; Isothiocyanates; Male; Mice, Inbred Strains; Morpholines; Neostigmine; Panax; Phytotherapy; Plant Extracts; Thiazoles; Wasabia; Zanthoxylum; Zingiberaceae | 2021 |
Available drugs and supplements for rapid deployment for treatment of COVID-19.
Topics: Adenosine Monophosphate; Alanine; Animals; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Drug Repositioning; Flavonoids; Humans; Mice; Nitro Compounds; Pharmaceutical Preparations; SARS-CoV-2; Small Molecule Libraries; Teicoplanin; Thiazoles | 2021 |
Cigarette smoke extract promotes DNA methyltransferase 3a expression in dendritic cells, inducing Th-17/Treg imbalance via the c-Jun/allograft inflammatory factor 1 axis.
Topics: Allografts; Animals; Anthracenes; Calcium-Binding Proteins; CD4-Positive T-Lymphocytes; Cell Differentiation; Cells, Cultured; Dendritic Cells; Disease Models, Animal; DNA Methyltransferase 3A; Enzyme Inhibitors; Male; Mice; Mice, Inbred BALB C; Microfilament Proteins; Proto-Oncogene Proteins c-jun; Pulmonary Disease, Chronic Obstructive; Signal Transduction; Smoke; Smoking; T-Lymphocytes, Regulatory; Tetrazolium Salts; Th17 Cells; Thiazoles | 2021 |
The immunomodulatory activity of secnidazole-nitazoxanide in a murine cryptosporidiosis model.
Topics: Animals; Antiprotozoal Agents; Cryptosporidiosis; Cryptosporidium parvum; Cytokines; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Ileum; Immunocompromised Host; Immunomodulation; Male; Metronidazole; Mice; Nitro Compounds; Parasite Load; Thiazoles | 2021 |
Synthesis and antimalarial and anticancer evaluation of 7-chlorquinoline-4-thiazoleacetic derivatives containing aryl hydrazide moieties.
Topics: A549 Cells; Acetic Acid; Animals; Antimalarials; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Survival; Disease Models, Animal; Humans; Hydrazines; Inhibitory Concentration 50; Malaria; Male; MCF-7 Cells; Mice; Mice, Inbred BALB C; Quinolines; Structure-Activity Relationship; Thiazoles | 2021 |
Efficacy of the combination of KPR-5714, a novel transient receptor potential melastatin 8 (TRPM8) antagonist, and β
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Calcium Signaling; Cyclic AMP; Disease Models, Animal; Drug Therapy, Combination; Female; HEK293 Cells; Humans; Muscarinic Antagonists; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-3; Thiazoles; Tolterodine Tartrate; TRPM Cation Channels; Urinary Bladder; Urinary Bladder, Overactive; Urodynamics | 2021 |
Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis.
Topics: Aniline Compounds; Animals; Disease Models, Animal; Image Processing, Computer-Assisted; Lysophosphatidylcholines; Magnetic Resonance Imaging; Mice, Inbred C57BL; Multiple Sclerosis; Myelin Sheath; Positron-Emission Tomography; Rats; Stereotaxic Techniques; Thiazoles | 2021 |
Addressing the role of 11β-hydroxysteroid dehydrogenase type 1 in the development of polycystic ovary syndrome and the putative therapeutic effects of its selective inhibition in a preclinical model.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Inhibitors; Female; Humans; Infertility, Female; Insulin Resistance; Ovary; Piperazines; Polycystic Ovary Syndrome; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles | 2021 |
Sustained release of PKR inhibitor C16 from mesoporous silica nanoparticles significantly enhances mRNA translation and anti-tumor vaccination.
Topics: Animals; Cancer Vaccines; Delayed-Action Preparations; Dendritic Cells; Disease Models, Animal; Drug Carriers; Drug Screening Assays, Antitumor; eIF-2 Kinase; Female; Fibroblasts; Hep G2 Cells; Humans; Indoles; Injections, Subcutaneous; Mice; Nanoparticles; Neoplasms; NIH 3T3 Cells; RNA, Messenger; Silicon Dioxide; Thiazoles | 2021 |
JWX-A0108, a positive allosteric modulator of α7 nAChR, attenuates cognitive deficits in APP/PS1 mice by suppressing NF-κB-mediated inflammation.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Cognition Disorders; Disease Models, Animal; Inflammation; Mice; Mice, Transgenic; Morris Water Maze Test; NF-kappa B; Pyrimidines; Thiazoles | 2021 |
Synthesis and Evaluation of PPARδ Agonists That Promote Osteogenesis in a Human Mesenchymal Stem Cell Culture and in a Mouse Model of Human Osteoporosis.
Topics: Animals; Cell Differentiation; Disease Models, Animal; Drug Design; Female; Femur; Humans; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Osteogenesis; Osteoporosis; PPAR delta; Structure-Activity Relationship; Thiazoles; X-Ray Microtomography | 2021 |
Leveraging copper import by yersiniabactin siderophore system for targeted PET imaging of bacteria.
Topics: Animals; Bacteria; Bacterial Infections; Copper; Disease Models, Animal; Echocardiography; Female; Mice; Mice, Inbred BALB C; Molecular Imaging; Phenols; Positron-Emission Tomography; Siderophores; Thiazoles | 2021 |
Partial Agonist Activity of Neonicotinoids on Rat Nicotinic Receptors: Consequences over Epinephrine Secretion and In Vivo Blood Pressure.
Topics: Adrenal Medulla; Animals; Arterial Pressure; Disease Models, Animal; Drug Partial Agonism; Epinephrine; Ganglia; Gene Expression Regulation; Guanidines; Insecticides; Male; Neonicotinoids; Nicotine; Rats; Receptors, Nicotinic; Thiazoles; Toxicity Tests, Subacute | 2021 |
Anti-inflammatory effects of a novel phosphodiesterase-4 inhibitor, AA6216, in mouse dermatitis models.
Topics: Animals; Anti-Inflammatory Agents; Boron Compounds; Bridged Bicyclo Compounds, Heterocyclic; Dermatitis, Atopic; Dermatophagoides farinae; Disease Models, Animal; Female; Humans; Leukocytes, Mononuclear; Mice; Oxazoles; Oxazolone; Phosphodiesterase 4 Inhibitors; Piperazines; Severity of Illness Index; Skin; Thiazoles | 2021 |
Mirabegron Ameliorated Atherosclerosis of ApoE
Topics: Acetanilides; Animals; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Humans; Hypoxia; Mice; Oxygen; Reactive Oxygen Species; Receptors, Adrenergic; Sleep Apnea, Obstructive; Thiazoles | 2022 |
Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models.
Topics: Animals; Antiviral Agents; Azocines; Benzhydryl Compounds; Disease Models, Animal; Genome, Viral; Hep G2 Cells; Hepatitis B; Hepatitis B virus; Hepatocytes; Host-Pathogen Interactions; Humans; Inhibitor of Apoptosis Proteins; Liver; Mice, Inbred C57BL; Mice, Knockout; Molecular Targeted Therapy; Organoids; Thiazoles; Tumor Necrosis Factor-alpha; Virus Replication | 2021 |
3-Hydroxykynurenine Regulates Lipopolysaccharide-Stimulated IL-6 Production and Protects against Endotoxic Shock in Mice.
Topics: Activating Transcription Factor 4; Animals; Disease Models, Animal; Humans; Interleukin-6; Kynurenine; Kynurenine 3-Monooxygenase; Lipopolysaccharides; Liver; Macrophages; Male; Mice; Mice, Knockout; Shock, Septic; Signal Transduction; Sulfonamides; Thiazoles | 2021 |
Liver X Receptor Agonist AZ876 Induces Beneficial Endogenous Cardiac Lipid Reprogramming and Protects Against Isoproterenol-Induced Cardiac Damage.
Topics: Aniline Compounds; Animals; Cellular Reprogramming; Disease Models, Animal; Fatty Acids; Fibrosis; Heart Diseases; Isoproterenol; Liver X Receptors; Male; Mice; Mice, 129 Strain; Myocardium; Thiazoles | 2021 |
Effects of β3-adrenoceptor agonist on acute urinary retention in a rat model.
Topics: Acetanilides; Acute Disease; Adrenergic beta-3 Receptor Agonists; Animals; Disease Models, Animal; Rats; Rats, Sprague-Dawley; Thiazoles; Urinary Retention | 2021 |
Blocking AURKA with MK-5108 attenuates renal fibrosis in chronic kidney disease.
Topics: Animals; Aurora Kinase A; Biopsy; Cell Line; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Disease Models, Animal; Female; Fibrosis; Humans; Infant; Kidney; Male; Mice; Rats; Renal Insufficiency, Chronic; Thiazoles | 2021 |
Blockade of T helper 17 cell function ameliorates recurrent Clostridioides difficile infection in mice.
Topics: Animals; Apoptosis; Cell Line, Tumor; Clostridium Infections; Colon; Disease Models, Animal; Intestinal Mucosa; Janus Kinase 2; Male; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 3; Recurrence; STAT3 Transcription Factor; Sulfonamides; Th17 Cells; Thiazoles | 2021 |
RORγt inhibitor SR1001 alleviates acute pancreatitis by suppressing pancreatic IL-17-producing Th17 and γδ-T cells in mice with ceruletide-induced pancreatitis.
Topics: Acute Disease; Adult; Aged; Animals; Case-Control Studies; Ceruletide; Disease Models, Animal; Disease Progression; Female; Humans; Interleukin-17; Intraepithelial Lymphocytes; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred C57BL; Middle Aged; Nuclear Receptor Subfamily 1, Group F, Member 3; Pancreatitis; Sulfonamides; Th17 Cells; Thiazoles | 2021 |
Largazole Inhibits Ocular Angiogenesis by Modulating the Expression of VEGFR2 and p21.
Topics: Angiogenesis Inhibitors; Animals; Aquatic Organisms; Cyanobacteria; Depsipeptides; Disease Models, Animal; Endothelial Cells; Eye; Eye Diseases; Female; Humans; Male; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Phytotherapy; Thiazoles; Vascular Endothelial Growth Factor Receptor-2 | 2021 |
Cyclooxygenase-2 Signalling Pathway in the Cortex is Involved in the Pathophysiological Mechanisms in the Rat Model of Depression.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Cytokines; Depression; Dinoprostone; Disease Models, Animal; Gene Expression Regulation; Male; Meloxicam; Rats; RNA Interference; Signal Transduction; Superoxide Dismutase; Thiazines; Thiazoles | 2017 |
Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kα-selective Inhibitors in Breast Cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Drug Resistance; Female; Gene Expression Profiling; Heterografts; Humans; Mice, SCID; Protein-Tyrosine Kinases; Thiazoles; Treatment Failure | 2017 |
cAMP/PKA-CREB-BDNF signaling pathway in hippocampus mediates cyclooxygenase 2-induced learning/memory deficits of rats subjected to chronic unpredictable mild stress.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Disease Models, Animal; Gene Expression Regulation; Hippocampus; Inflammation Mediators; Learning; Meloxicam; Memory; Memory Disorders; Rats; Signal Transduction; Stress, Psychological; Synapses; Thiazines; Thiazoles | 2017 |
Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biomarkers; Cell Line, Tumor; Cell Survival; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Evaluation, Preclinical; Female; Glioblastoma; Humans; Leukocytes; Mice; Naphthyridines; Necrosis; Radiation Tolerance; Survival Rate; Thiazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
Effects of an EP2 and EP3 Receptor Dual Agonist, ONO-8055, on a Radical Hysterectomy-Induced Underactive Bladder Model in Monkeys.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Female; Hysterectomy; Macaca fascicularis; Muscle Contraction; Pyridinium Compounds; Receptors, Prostaglandin E, EP2 Subtype; Receptors, Prostaglandin E, EP3 Subtype; Rheology; Thiazoles; Urinary Bladder, Neurogenic; Urination | 2018 |
Synergistic antitumor effects of CDK inhibitor SNS‑032 and an oncolytic adenovirus co‑expressing TRAIL and Smac in pancreatic cancer.
Topics: Adenoviridae; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle Checkpoints; Cell Line, Tumor; Combined Modality Therapy; Disease Models, Animal; Gene Expression; Genetic Therapy; Genetic Vectors; Humans; Intracellular Signaling Peptides and Proteins; Male; Mice; Mitochondrial Proteins; Oncolytic Virotherapy; Oncolytic Viruses; Oxazoles; Pancreatic Neoplasms; Signal Transduction; Thiazoles; TNF-Related Apoptosis-Inducing Ligand; Xenograft Model Antitumor Assays | 2017 |
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases.
Topics: Animals; Antitubercular Agents; Chagas Disease; Disease Models, Animal; Mice; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Structure-Activity Relationship; Thiazoles; Tuberculosis | 2017 |
Micturition dysfunction in four-month old ovariectomized rats: Effects of testosterone replacement.
Topics: Acetanilides; Androgens; Angiotensin II; Animals; Carbachol; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Injections, Intramuscular; Letrozole; Muscle, Smooth; Nitriles; Ovariectomy; Postmenopause; Rats; Rats, Sprague-Dawley; Testosterone; Thiazoles; Triazoles; Urethra; Urination Disorders | 2017 |
XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G.
Topics: Acetylglucosamine; Age Factors; Animals; Brain Ischemia; Disease Models, Animal; Infarction, Middle Cerebral Artery; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotection; Protein Folding; Protein Serine-Threonine Kinases; Pyrans; Stroke; Thiazoles; Unfolded Protein Response; X-Box Binding Protein 1 | 2017 |
The Role of 5-HTR6 in Mossy Fiber Sprouting: Activating Fyn and p-ERK1/2 in Pilocarpine-Induced Chronic Epileptic Rats.
Topics: Animals; Disease Models, Animal; Epilepsy; Flavonoids; GAP-43 Protein; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscarinic Agonists; Pilocarpine; Proto-Oncogene Proteins c-fyn; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; RNA, Messenger; Serotonin Receptor Agonists; Status Epilepticus; Thiazoles; Time Factors; Tryptamines; Up-Regulation | 2017 |
Müller glial cell reactivation in Xenopus models of retinal degeneration.
Topics: Age Factors; Animals; Animals, Genetically Modified; Animals, Newborn; Bromodeoxyuridine; Cell Proliferation; Diamines; Disease Models, Animal; Ependymoglial Cells; Gene Expression Regulation; Green Fluorescent Proteins; Metronidazole; Proliferating Cell Nuclear Antigen; Radiation-Sensitizing Agents; Regeneration; Retinal Degeneration; Rhodopsin; SOX9 Transcription Factor; Thiazoles; Urea; Xenopus laevis | 2017 |
Anti-stress effects of a GSK-3β inhibitor, AR-A014418, in immobilization stress of variable duration in mice.
Topics: Animals; Behavior, Animal; Brain; Corticosterone; Disease Models, Animal; Glycogen Synthase Kinase 3 beta; Mice; Motor Activity; Stress, Psychological; Thiazoles; Urea | 2017 |
Predator odor evokes sex-independent stress responses in male and female Wistar rats and reduces phosphorylation of cyclic-adenosine monophosphate response element binding protein in the male, but not the female hippocampus.
Topics: Animals; Blood Glucose; Corticosterone; CREB-Binding Protein; Cyclic AMP; Disease Models, Animal; Fear; Female; Hippocampus; Immobility Response, Tonic; Male; MAP Kinase Signaling System; Maze Learning; Odorants; Phosphorylation; Rats; Rats, Wistar; Sex Factors; Stress Disorders, Post-Traumatic; Thiazoles | 2017 |
Applicability of [
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Carbon Radioisotopes; Disease Models, Animal; Female; Follow-Up Studies; Humans; Liposomes; Male; Mice, Transgenic; Nanoparticles; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2017 |
Sensitization of TRPV1 and TRPA1 via peripheral mGluR5 signaling contributes to thermal and mechanical hypersensitivity.
Topics: Acetanilides; Animals; Disease Models, Animal; Enzyme Inhibitors; Freund's Adjuvant; Glutamic Acid; Glycine; Hyperalgesia; Male; Neurons; Pain; Pain Threshold; Phenylacetates; Physical Stimulation; Purines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Signal Transduction; Skin; Thiazoles; Trigeminal Ganglion; TRPA1 Cation Channel; TRPV Cation Channels | 2017 |
D-512, a novel dopamine D
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dopamine Agonists; Dose-Response Relationship, Drug; Indoles; Male; Molecular Structure; Parkinson Disease; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, Dopamine D3; Structure-Activity Relationship; Thiazoles | 2017 |
Modulation of the peri-infarct neurogliovascular function by delayed COX-1 inhibition.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelin-1; Ischemia; Macrophages; Magnetic Resonance Imaging; Male; Membrane Proteins; Microglia; Neuroglia; Neurons; Perfusion; Piperazines; Rats; Rats, Sprague-Dawley; Spin Labels; Stroke; Thiazoles | 2017 |
Synthesis and diabetic neuropathic pain-alleviating effects of 2N-(pyrazol-3-yl)methylbenzo[d]isothiazole-1,1-dioxide derivatives.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Diabetic Neuropathies; Disease Models, Animal; Half-Life; Humans; Inhibitory Concentration 50; Male; Microsomes, Liver; Neuralgia; Pyrazoles; Rats; Structure-Activity Relationship; Thiazoles | 2017 |
Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Capillaries; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Exploratory Behavior; Intussusception; Kidney Glomerulus; Liver; Male; Memory, Short-Term; Mice, Transgenic; Microvessels; Plaque, Amyloid; Spleen; Thiazoles | 2017 |
Topical ROR Inverse Agonists Suppress Inflammation in Mouse Models of Atopic Dermatitis and Acute Irritant Dermatitis.
Topics: Animals; Cell Differentiation; Cytokines; Dermatitis, Atopic; Dermatitis, Irritant; Disease Models, Animal; Eczema; Epidermis; Female; Inflammation; Keratinocytes; Ligands; Mice; Mice, Inbred C57BL; Nuclear Receptor Subfamily 1, Group F, Member 1; Skin; Sulfonamides; Thiazoles | 2017 |
Modulation of periodontitis progression using pH-responsive nanosphere encapsulating metronidazole or N-phenacylthialzolium bromide.
Topics: Animals; Anti-Infective Agents; Chitosan; Disease Models, Animal; Disease Progression; Lactic Acid; Metronidazole; Nanospheres; Periodontitis; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats, Sprague-Dawley; Thiazoles | 2018 |
Effects of haloperidol, olanzapine, ziprasidone, and PHA-543613 on spatial learning and memory in the Morris water maze test in naïve and MK-801-treated mice.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Haloperidol; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Olanzapine; Piperazines; Quinuclidines; Schizophrenia; Spatial Learning; Thiazoles; Treatment Outcome | 2017 |
Therapeutic potential for leukocyte elastase in chronic pain states harboring a neuropathic component.
Topics: Analgesics; Animals; Cancer Pain; Chronic Pain; Cyclic S-Oxides; Disease Models, Animal; Female; Glycine; Hyperalgesia; Leukocyte Elastase; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Motor Activity; Neuralgia; Pain Measurement; Pain Threshold; Pregabalin; Serine Proteinase Inhibitors; Sulfonamides; Thiazoles | 2017 |
Elevated intrathymic sphingosine-1-phosphate promotes thymus involution during sepsis.
Topics: Aminophenols; Animals; Apoptosis; Atrophy; Cecum; Disease Models, Animal; Interleukin-6; Lymphocytosis; Lymphopenia; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Sepsis; Sphingosine; Thiazoles; Thymocytes; Thymus Gland | 2017 |
Edoxaban improves venous thrombosis via increasing hydrogen sulfide and homocysteine in rat model.
Topics: Animals; Anticoagulants; Chlorides; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelial Cells; Ferric Compounds; Gene Expression Regulation; Homocysteine; Hydrogen Sulfide; Male; Matrix Metalloproteinase 9; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Pyridines; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazoles; Venous Thrombosis | 2017 |
The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis.
Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Antiparasitic Agents; Azithromycin; Cryptosporidiosis; Cryptosporidium; Disease Models, Animal; Drug Therapy, Combination; Nitro Compounds; Sus scrofa; Swine; Thiazoles; Treatment Outcome | 2017 |
Neuroinflammation Appears Early on PET Imaging and Then Plateaus in a Mouse Model of Alzheimer Disease.
Topics: Alzheimer Disease; Aniline Compounds; Animals; Benzothiazoles; Brain; Carbazoles; Disease Models, Animal; Female; Inflammation; Longitudinal Studies; Mice; Positron-Emission Tomography; Thiazoles | 2018 |
Evidence for mast cells contributing to neuromuscular pathology in an inherited model of ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Benzamides; Disease Models, Animal; Male; Mast Cells; Muscle, Skeletal; Neuromuscular Diseases; Neuromuscular Junction; Piperidines; Pyridines; Rats; Thiazoles | 2017 |
γ-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma.
Topics: Amyloid Precursor Protein Secretases; Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Proliferation; Diamines; Disease Models, Animal; Head and Neck Neoplasms; Humans; Immunosuppression Therapy; Mice; Mice, Knockout; Myeloid Cells; Protein Serine-Threonine Kinases; PTEN Phosphohydrolase; Receptor, Notch1; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; T-Lymphocytes, Regulatory; Thiazoles; Tumor Cells, Cultured; Tumor Escape | 2018 |
JTE-852, a novel spleen tyrosine kinase inhibitor, blocks immunoglobulin G-mediated cellular responses and autoimmune reactions in vivo.
Topics: Aminopyridines; Animals; Arthritis, Experimental; Autoimmune Diseases; Autoimmunity; Cells, Cultured; Disease Models, Animal; Female; Humans; Immunoglobulin G; Male; Mast Cells; Monocytes; Passive Cutaneous Anaphylaxis; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Syk Kinase; Thiazoles | 2017 |
Exposure to neonicotinoid insecticides induces embryotoxicity in mice and rabbits.
Topics: Animals; Blastocyst; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Guanidines; Insecticides; Male; Mice; Mice, Inbred ICR; Neonicotinoids; Nitro Compounds; Oxazines; Rabbits; Thiamethoxam; Thiazines; Thiazoles | 2017 |
Efficacy of pritelivir and acyclovir in the treatment of herpes simplex virus infections in a mouse model of herpes simplex encephalitis.
Topics: Acyclovir; Animals; Antiviral Agents; Disease Models, Animal; Drug Therapy, Combination; Encephalitis, Herpes Simplex; Female; Humans; Mice; Pyridines; Sulfonamides; Thiazoles; Tissue Distribution; Treatment Outcome | 2018 |
Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice.
Topics: Actins; Adaptor Proteins, Signal Transducing; Animals; Dendritic Spines; Disease Models, Animal; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factor-4G; Fragile X Mental Retardation Protein; Fragile X Syndrome; Hippocampus; Hydrazones; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Thiazoles | 2017 |
Analgesics promote welfare and sustain tumour growth in orthotopic 4T1 and B16 mouse cancer models.
Topics: Analgesics; Animal Welfare; Animals; Breast Neoplasms; Buprenorphine; Cell Line, Tumor; Disease Models, Animal; Female; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma, Experimental; Meloxicam; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Metastasis; Pain; Thiazines; Thiazoles; Xenograft Model Antitumor Assays | 2018 |
Modulation of sphingosine 1-phosphate (S1P) attenuates spatial learning and memory impairments in the valproic acid rat model of autism.
Topics: Analysis of Variance; Animals; Apoptosis; Autistic Disorder; Autophagy; Biomarkers; Disease Models, Animal; Hippocampus; Humans; Lysophospholipids; Male; Memory Disorders; Neurons; Phosphotransferases (Alcohol Group Acceptor); Rats; Rats, Wistar; Signal Transduction; Spatial Learning; Sphingosine; Thiazoles; Valproic Acid | 2018 |
PDGFB as a vascular normalization agent in an ovarian cancer model treated with a gamma-secretase inhibitor.
Topics: Amyloid Precursor Protein Secretases; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Diamines; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Ovarian Neoplasms; Proto-Oncogene Proteins c-sis; Thiazoles | 2018 |
Highly selective peroxisome proliferator-activated receptor δ (PPARδ) modulator demonstrates improved safety profile compared to GW501516.
Topics: Animals; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Molecular Structure; PPAR delta; Rats; Structure-Activity Relationship; Thiazoles | 2018 |
Rutin and meloxicam attenuate paw inflammation in mice: Affecting sorbitol dehydrogenase activity.
Topics: Acute Pain; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Apoptosis; Behavior, Animal; Cellulitis; Connective Tissue; Disease Models, Animal; Drug Therapy, Combination; Edema; L-Iditol 2-Dehydrogenase; Liver; Male; Meloxicam; Mice; Organ Size; Oxidative Stress; Random Allocation; Rutin; Superoxide Dismutase; Thiazines; Thiazoles | 2018 |
Selective Blockade of the Metabotropic Glutamate Receptor mGluR5 Protects Mouse Livers in In Vitro and Ex Vivo Models of Ischemia Reperfusion Injury.
Topics: Adenosine Triphosphate; Animals; Cell Hypoxia; Disease Models, Animal; Hepatocytes; Imidazoles; Liver; Mice; Mitochondria, Liver; Piperidines; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Reperfusion Injury; Thiazoles; Tumor Necrosis Factor-alpha | 2018 |
JTE-852, a novel spleen tyrosine kinase inhibitor, blocks antigen-induced allergic reactions in rats.
Topics: Airway Obstruction; Aminopyridines; Animals; Antigens; Cytokines; Disease Models, Animal; Hypersensitivity; Male; Mast Cells; Nasal Mucosa; Protein-Tyrosine Kinases; Rats; Rats, Inbred BN; Respiratory Hypersensitivity; Sneezing; Spleen; Thiazoles | 2018 |
Notch signaling inhibitor DAPT provides protection against acute craniocerebral injury.
Topics: Animals; Apoptosis Regulatory Proteins; Basic Helix-Loop-Helix Transcription Factors; Brain Injuries, Traumatic; Craniocerebral Trauma; Diamines; Disease Models, Animal; Down-Regulation; Male; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Notch; Repressor Proteins; RNA, Messenger; Signal Transduction; Thiazoles; Transcription Factor HES-1 | 2018 |
Von Hippel-Lindau mutations disrupt vascular patterning and maturation via Notch.
Topics: Animals; Diamines; Disease Models, Animal; Endothelial Cells; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hemangioblastoma; Humans; Male; Mice; Mice, Transgenic; Microvessels; Mutation; Receptors, Notch; Retinal Artery; Thiazoles; von Hippel-Lindau Disease; Von Hippel-Lindau Tumor Suppressor Protein | 2018 |
Thiazole derivatives act on virulence factors of Cryptococcus spp.
Topics: Animals; Antifungal Agents; Biofilms; Cells, Cultured; Cryptococcosis; Cryptococcus; Disease Models, Animal; Fungal Polysaccharides; Larva; Macrophages; Mice; Molecular Structure; Moths; Phagocytosis; Survival Analysis; Thiazoles; Virulence Factors | 2019 |
Antinociceptive effect of two novel transient receptor potential melastatin 8 antagonists in acute and chronic pain models in rat.
Topics: Acute Pain; Analgesics; Animals; Chronic Pain; Disease Models, Animal; HEK293 Cells; Humans; Male; Rats; Rats, Sprague-Dawley; Tetrazoles; Thiazoles; TRPM Cation Channels | 2018 |
Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer's disease, whereas amyloid deposition does not.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Brain; Disease Models, Animal; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Positron-Emission Tomography; Presenilin-1; Psychiatric Status Rating Scales; Thiamine; Thiamine Pyrophosphate; Thiazoles | 2018 |
Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice.
Topics: Animals; Combined Modality Therapy; Disease Models, Animal; Drug Interactions; Female; Mice; Microbial Sensitivity Tests; Nitroimidazoles; Thiazoles; Triazoles; Trypanocidal Agents; Trypanosoma cruzi | 2018 |
Neuroprotective effect of IDPU (1-(7-imino-3-propyl-2,3-dihydrothiazolo [4,5-d]pyrimidin-6(7H)-yl)urea) in 6-OHDA induced rodent model of hemiparkinson's disease.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Depression; Disease Models, Animal; Male; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Parkinsonian Disorders; Rats, Wistar; Reactive Oxygen Species; Rotarod Performance Test; Thiazoles; Tyrosine 3-Monooxygenase; Urea | 2018 |
Design and Synthesis of Novel Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors with the Ability To Rescue Auditory Gating Deficit in Mice.
Topics: Acetylcholine; Administration, Oral; Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Blood-Brain Barrier; Disease Models, Animal; Drug Design; Evoked Potentials; Half-Life; Humans; Mice; Oocysts; Rats; Schizophrenia; Structure-Activity Relationship; Thiazoles; Xenopus laevis | 2019 |
Andexanet alfa effectively reverses edoxaban anticoagulation effects and associated bleeding in a rabbit acute hemorrhage model.
Topics: Animals; Anticoagulants; Antidotes; Blood Coagulation; Disease Models, Animal; Factor Xa; Factor Xa Inhibitors; Hemorrhage; Male; Pyridines; Rabbits; Recombinant Proteins; Thiazoles | 2018 |
Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy.
Topics: Animals; beta-N-Acetylhexosaminidases; Brain; Disease Models, Animal; Disease Progression; Doxycycline; Enzyme Inhibitors; Gene Expression; Humans; Mice; Mice, 129 Strain; Mice, Transgenic; Motor Activity; Mutant Proteins; Neurofibrillary Tangles; Phosphorylation; Pyrans; Recombinant Proteins; tau Proteins; Tauopathies; Thiazoles | 2018 |
Visual Evoked Potential Recovery by Subretinal Implantation of Photoelectric Dye-Coupled Thin Film Retinal Prosthesis in Monkey Eyes With Macular Degeneration.
Topics: Aniline Compounds; Animals; Disease Models, Animal; Evoked Potentials, Visual; Feasibility Studies; Light; Macaca fascicularis; Macular Degeneration; Pilot Projects; Polyethylene; Prosthesis Design; Prosthesis Implantation; Recovery of Function; Retina; Surface Properties; Thiazoles; Time Factors; Visual Prosthesis | 2018 |
Heme Oxygenase-1 Activity as a Correlate to Exercise-Mediated Amelioration of Cognitive Decline and Neuropathological Alterations in an Aging Rat Model of Dementia.
Topics: Aging; Amyloid; Aniline Compounds; Animals; Brain; Cerebral Amyloid Angiopathy; Cognitive Dysfunction; Dementia; Disease Models, Animal; Female; Heme Oxygenase-1; Male; Maze Learning; Physical Conditioning, Animal; Positron-Emission Tomography; Rats, Wistar; Spatial Memory; Thiazoles | 2018 |
Contribution of yersiniabactin to the virulence of an Escherichia coli sequence type 69 ("clonal group A") cystitis isolate in murine models of urinary tract infection and sepsis.
Topics: Animals; Cystitis; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Female; Gene Deletion; Genetic Complementation Test; Iron Regulatory Protein 2; Mice; Mutation; Phenols; Sepsis; Thiazoles; Urinary Tract Infections; Virulence; Virulence Factors | 2018 |
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.
Topics: Aging, Premature; Animals; Disease Models, Animal; DNA Damage; Female; Genomic Instability; Humans; Hydrazones; Kaplan-Meier Estimate; Lamin Type A; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Terminal Acetyltransferase A; N-Terminal Acetyltransferases; Progeria; Thiazoles | 2018 |
Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens.
Topics: Acetaldehyde; Alcohol Drinking; Animals; Binge Drinking; Brain; Central Nervous System Depressants; Disease Models, Animal; Dopamine; Enzyme Inhibitors; Ethanol; Kynurenine; Kynurenine 3-Monooxygenase; Male; Mice, Inbred C57BL; Nucleus Accumbens; Receptors, Cholinergic; Sulfonamides; Thiazoles | 2018 |
Blockade of anoctamin-1 in injured and uninjured nerves reduces neuropathic pain.
Topics: Activating Transcription Factor 3; Animals; Anoctamin-1; Caspase 3; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Injections, Spinal; Ligation; Neuralgia; Pyrimidines; Rats; Rats, Wistar; Spinal Nerves; Thiazoles | 2018 |
Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP
Topics: Animals; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Discovery; Fracture Healing; Fractures, Bone; Madin Darby Canine Kidney Cells; Mice; Mice, Knockout; Molecular Structure; Receptors, Prostaglandin E, EP1 Subtype; Structure-Activity Relationship; Thiazoles | 2018 |
Inhibition of GSK-3β on Behavioral Changes and Oxidative Stress in an Animal Model of Mania.
Topics: Aldehydes; Animals; Antioxidants; Behavior, Animal; Bipolar Disorder; Catalase; Dinoprost; Disease Models, Animal; Glutathione Peroxidase; Glycogen Synthase Kinase 3 beta; Lipid Peroxidation; Male; Motor Activity; Oxidative Stress; Protein Carbonylation; Rats, Wistar; Submitochondrial Particles; Superoxide Dismutase; Superoxides; Thiazoles; Tyrosine; Urea | 2019 |
Mirabegron, a Clinically Approved β3 Adrenergic Receptor Agonist, Does Not Reduce Infarct Size in a Swine Model of Reperfused Myocardial Infarction.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Disease Models, Animal; Magnetic Resonance Imaging, Cine; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Random Allocation; Swine; Thiazoles; Ventricular Function, Left; Ventricular Remodeling | 2018 |
KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.
Topics: Animals; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Chaperonin 60; Citric Acid Cycle; Disease Models, Animal; Energy Metabolism; Glioblastoma; Glycolysis; Humans; Metabolic Networks and Pathways; Mitochondria; Mitochondrial Proteins; Neoplasm Invasiveness; Stress, Physiological; Survival Analysis; Thiazoles; Transcription, Genetic; Xenograft Model Antitumor Assays | 2018 |
Transient inhibition of sphingosine kinases confers protection to influenza A virus infected mice.
Topics: A549 Cells; Adamantane; Administration, Oral; Amino Alcohols; Aminophenols; Animals; Cell Line; Disease Models, Animal; Female; Gene Knockdown Techniques; HEK293 Cells; Humans; Influenza A virus; Mice; Mice, Inbred C57BL; Orthomyxoviridae Infections; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Isoforms; Pyridines; RNA, Small Interfering; Sphingosine; Thiazoles; Virus Replication | 2018 |
GSK3β Inhibition Restores Impaired Neurogenesis in Preterm Neonates With Intraventricular Hemorrhage.
Topics: Animals; Apoptosis; Blotting, Western; Case-Control Studies; Cell Count; Cell Proliferation; Cerebral Cortex; Cerebral Intraventricular Hemorrhage; Disease Models, Animal; Ependymoglial Cells; Glycogen Synthase Kinase 3 beta; Humans; Immunohistochemistry; Infant, Extremely Premature; Infant, Newborn; Ki-67 Antigen; Lateral Ventricles; Neural Stem Cells; Neurogenesis; PAX6 Transcription Factor; Phosphorylation; Pyramidal Cells; Rabbits; Real-Time Polymerase Chain Reaction; Retinoblastoma Protein; SOXB1 Transcription Factors; T-Box Domain Proteins; Thiazoles; Urea; White Matter | 2019 |
N-Thiazolylamide-based free fatty-acid 2 receptor agonists: Discovery, lead optimization and demonstration of off-target effect in a diabetes model.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Humans; Mice; Mice, Knockout; Molecular Structure; Rats; Receptors, Cell Surface; Structure-Activity Relationship; Thiazoles | 2018 |
A Novel Magnetic Nanoparticle for Early Detection of Amyloid Plaques in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Cell Line; Disease Models, Animal; Dogs; Early Diagnosis; Female; Humans; Immunohistochemistry; Madin Darby Canine Kidney Cells; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Positron-Emission Tomography; Surface-Active Agents; Thiazoles | 2018 |
Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS.
Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Benzamides; Cell Degranulation; Disease Models, Animal; Humans; Male; Mast Cells; Motor Neurons; Muscle, Skeletal; Neuromuscular Junction; Neutrophil Infiltration; Neutrophils; Piperidines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Transgenic; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Treatment Outcome | 2018 |
A novel rat model of comorbid PTSD and addiction reveals intersections between stress susceptibility and enhanced cocaine seeking with a role for mGlu5 receptors.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Cocaine; Cocaine-Related Disorders; Comorbidity; Disease Models, Animal; Drug-Seeking Behavior; Extinction, Psychological; Fear; Male; Phenotype; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Resilience, Psychological; Stress Disorders, Post-Traumatic; Stress, Psychological; Thiazoles | 2018 |
Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have
Topics: Animals; Antiprotozoal Agents; Benzamides; Cryptosporidiosis; Cryptosporidium parvum; Disease Models, Animal; Mice, Inbred C57BL; Nitro Compounds; Pyruvate Synthase; Thiazoles; Weight Loss | 2018 |
Prevention of Stent Thrombosis in Rats by a Direct Oral Factor Xa Inhibitor Edoxaban.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Factor Xa Inhibitors; Fibrinolytic Agents; Male; Platelet Aggregation Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Stents; Thiazoles; Thrombosis | 2019 |
Disrupting the CD95-PLCγ1 interaction prevents Th17-driven inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Evaluation, Preclinical; fas Receptor; Female; Humans; Inflammation; Lupus Erythematosus, Systemic; Male; Mice, Mutant Strains; Molecular Docking Simulation; Peptidomimetics; Phospholipase C gamma; Protein Domains; Ritonavir; Structure-Activity Relationship; Th17 Cells; Thiazoles | 2018 |
RKI-1447, a Rho kinase inhibitor, causes ocular hypotension, actin stress fiber disruption, and increased phagocytosis.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Glaucoma, Open-Angle; Intraocular Pressure; Ocular Hypotension; Phagocytosis; rho-Associated Kinases; Stress Fibers; Swine; Thiazoles; Trabecular Meshwork; Urea | 2019 |
A novel MyD88 inhibitor attenuates allograft rejection after heterotopic tracheal transplantation in mice.
Topics: Animals; Antibodies, Monoclonal; Bronchiolitis Obliterans; CD40 Ligand; Cytokines; Disease Models, Animal; Drug Therapy, Combination; Graft Rejection; Humans; Immunologic Factors; Inflammation Mediators; Lung Transplantation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Piperazines; Thiazoles; Trachea; Transplantation, Heterotopic; Transplantation, Homologous | 2019 |
Modulating the conformation of the TIR domain by a neoteric MyD88 inhibitor leads to the separation of GVHD from GVT.
Topics: Administration, Oral; Animals; Bone Marrow Cells; Bone Marrow Transplantation; Cell Line, Tumor; Cell Proliferation; Dendritic Cells; Disease Models, Animal; Female; Graft vs Host Disease; Graft vs Tumor Effect; HEK293 Cells; Humans; Immunosuppressive Agents; Lymphocyte Activation; Male; Mice; Multiple Myeloma; Myeloid Differentiation Factor 88; Piperazines; Primary Cell Culture; Protein Domains; Protein Multimerization; Thiazoles; Transplantation, Homologous | 2019 |
Activation of Aryl Hydrocarbon Receptor Negatively Regulates Thymic Stromal Lymphopoietin Gene Expression via Protein Kinase Cδ-p300-NF-κB Pathway in Keratinocytes under Inflammatory Conditions.
Topics: Animals; Cells, Cultured; Cytokines; Dermatitis, Atopic; Dermatitis, Contact; Disease Models, Animal; Down-Regulation; Female; Gene Expression Regulation; Humans; Indoles; Keratinocytes; Mice, Inbred BALB C; Protein Kinase C-delta; Receptors, Aryl Hydrocarbon; Signal Transduction; Thiazoles; Thymic Stromal Lymphopoietin; Transcriptional Activation | 2019 |
The SMAC mimetic LCL-161 displays antitumor activity in preclinical models of rituximab-resistant B-cell lymphoma.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Drug Resistance, Neoplasm; Drug Therapy, Combination; Humans; Inhibitor of Apoptosis Proteins; Lymphoma, B-Cell; Mice; Mice, SCID; Oligopeptides; Proteasome Inhibitors; Proto-Oncogene Proteins c-bcl-2; Rituximab; Survivin; Thiazoles; Transplantation, Heterologous | 2018 |
MDM2 inhibitor ameliorates cisplatin-induced nephropathy via NFκΒ signal inhibition.
Topics: Acute Kidney Injury; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion Molecules; Cisplatin; Disease Models, Animal; HEK293 Cells; Humans; Imidazoles; Kidney Tubules; Male; Neoplasms; NF-kappa B; Proto-Oncogene Proteins c-mdm2; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiazoles; Treatment Outcome | 2019 |
A novel MyD88 inhibitor LM9 prevents atherosclerosis by regulating inflammatory responses and oxidative stress in macrophages.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Diet, High-Fat; Disease Models, Animal; Gene Knockdown Techniques; Lipoproteins, LDL; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88; Oxidative Stress; Piperazines; RAW 264.7 Cells; Reactive Oxygen Species; Thiazoles | 2019 |
Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Astrocytes; Cognition; Culture Media, Conditioned; Disease Models, Animal; Gene Expression Regulation; Genes, Reporter; Hippocampus; Humans; Liver X Receptors; Luciferases; Male; Memory, Short-Term; Mice; Mice, Transgenic; Microglia; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Sargassum; Signal Transduction; Stigmasterol; Thiazoles | 2019 |
Evaluation of nitazoxanide as a novel drug for the treatment of acute and chronic toxoplasmosis.
Topics: Acute Disease; Animals; Antiparasitic Agents; Chronic Disease; Disease Models, Animal; Mice; Nitro Compounds; Thiazoles; Toxoplasma; Toxoplasmosis | 2019 |
PELI3 mediates pro-tumor actions of down-regulated miR-365a-5p in non-small cell lung cancer.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Coloring Agents; Disease Models, Animal; Down-Regulation; Humans; Lung Neoplasms; MicroRNAs; Tetrazolium Salts; Thiazoles; Ubiquitin-Protein Ligases | 2019 |
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antiparasitic Agents; Cells, Cultured; Disease Models, Animal; Humans; Learning; Memory Disorders; Mice; Nitro Compounds; Thiazoles | 2019 |
EGFP-EGF1-conjugated poly(lactic-co-glycolic acid) nanoparticles, a new diagnostic tool and drug carrier for atherosclerosis.
Topics: Animals; Aorta; Atherosclerosis; Coumarins; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Fluorescence; Green Fluorescent Proteins; Humans; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Nanoparticles; Particle Size; Peptide Elongation Factor G; Polylactic Acid-Polyglycolic Acid Copolymer; Static Electricity; Thiazoles | 2019 |
Early life exposure of a biocide, CMIT/MIT causes metabolic toxicity via the O-GlcNAc transferase pathway in the nematode C. elegans.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Disinfectants; Fatty Acids; Forkhead Transcription Factors; Humidifiers; Mutation; N-Acetylglucosaminyltransferases; Oxidative Stress; RNA Interference; Thiazoles | 2019 |
Adipose tissue macrophage-derived exosomal miR-29a regulates obesity-associated insulin resistance.
Topics: Adipocytes; Adipose Tissue; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Exosomes; Gene Knockdown Techniques; Hepatocytes; In Vitro Techniques; Insulin Resistance; Macrophages; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Muscle Cells; Obesity; Receptors, Cytoplasmic and Nuclear; Thiazoles | 2019 |
Age‑associated variation in the expression and function of TMEM16A calcium‑activated chloride channels in the cochlear stria vascularis of guinea pigs.
Topics: Aging; Animals; Anoctamin-1; Disease Models, Animal; Female; Galactose; Gene Expression Regulation; Guinea Pigs; Hearing; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Presbycusis; Pyrimidines; Stria Vascularis; Thiazoles | 2019 |
Modification of kynurenine pathway via inhibition of kynurenine hydroxylase attenuates surgical brain injury complications in a male rat model.
Topics: Animals; Apoptosis; Brain Edema; Brain Injuries; Cytokines; Disease Models, Animal; Kynurenine; Kynurenine 3-Monooxygenase; Male; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles | 2020 |
Evaluation of Myelin Radiotracers in the Lysolecithin Rat Model of Focal Demyelination: Beware of Pitfalls!
Topics: Aniline Compounds; Animals; Autoradiography; Brain Edema; Carbon Radioisotopes; Cerebral Ventricles; Corpus Callosum; Corpus Striatum; Demyelinating Diseases; Dilatation, Pathologic; Disease Models, Animal; Ethylene Glycols; False Positive Reactions; Fluorine Radioisotopes; Image Processing, Computer-Assisted; Injections; Lysophosphatidylcholines; Magnetic Resonance Imaging; Male; Multiple Sclerosis; Myelin Sheath; Neuroimaging; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Thiazoles | 2019 |
Mirabegron causes vesical and urethral relaxation in rats with spinal cord injury.
Topics: Acetanilides; Animals; Disease Models, Animal; Female; Rats; Rats, Sprague-Dawley; Solifenacin Succinate; Spinal Cord Injuries; Thiazoles; Urethra; Urinary Bladder; Urological Agents | 2020 |
Inhibition of connective tissue growth factor suppresses hepatic stellate cell activation in vitro and prevents liver fibrosis in vivo.
Topics: Animals; Blotting, Western; Cell Line; Cell Proliferation; Connective Tissue Growth Factor; Disease Models, Animal; Flow Cytometry; Gene Silencing; Hepatic Stellate Cells; Histocytochemistry; Humans; Lentivirus; Liver Cirrhosis; Male; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Small Interfering; Staining and Labeling; Tetrazolium Salts; Thiazoles | 2014 |
Age and meloxicam modify the response of the glutamate vesicular transporters (VGLUTs) after transient global cerebral ischemia in the rat brain.
Topics: Age Factors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Brain; Brain Ischemia; Disease Models, Animal; Male; Meloxicam; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Thiazines; Thiazoles; Vesicular Glutamate Transport Proteins | 2013 |
Anticancer effect of arsenic trioxide on cholangiocarcinoma: in vitro experiments and in vivo xenograft mouse model.
Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cholangiocarcinoma; Disease Models, Animal; Heterografts; Humans; Mice, Inbred BALB C; Mice, Nude; Oxides; Staining and Labeling; Tetrazolium Salts; Thiazoles; Treatment Outcome | 2014 |
Enteroaggregative Escherichia coli strain in a novel weaned mouse model: exacerbation by malnutrition, biofilm as a virulence factor and treatment by nitazoxanide.
Topics: Animals; Biofilms; Colon; Disease Models, Animal; Escherichia coli; Escherichia coli Infections; Feces; Humans; Male; Malnutrition; Mice; Mice, Inbred C57BL; Nitro Compounds; Thiazoles; Virulence; Virulence Factors; Weaning | 2013 |
Activity of halogeno-thiazolides against Cryptosporidium parvum in experimentally infected immunosuppressed gerbils (Meriones unguiculatus).
Topics: Animals; Antiparasitic Agents; Cryptosporidiosis; Cryptosporidium parvum; Disease Models, Animal; Gerbillinae; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Nitro Compounds; Thiazoles; Treatment Outcome | 2013 |
A peroxisome proliferator-activated receptor-δ agonist provides neuroprotection in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Cell Count; Cells, Cultured; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Female; Glial Fibrillary Acidic Protein; Humans; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroprotective Agents; Parkinsonian Disorders; PPAR delta; Rats; Sulfones; Thiazoles; Thiophenes; Tyrosine 3-Monooxygenase | 2013 |
The response of cerebral cortex to haemorrhagic damage: experimental evidence from a penetrating injury model.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astrocytes; Benzothiazoles; Brain; Brain Injuries; Cell Death; Cerebral Cortex; Congo Red; Disease Models, Animal; Female; Ferrocyanides; Heme; Hemorrhage; Hippocampus; Humans; Immunohistochemistry; Male; Neocortex; Neurons; Phosphorylation; Rats; Rats, Sprague-Dawley; tau Proteins; Temporal Lobe; Thiazoles; Wounds, Penetrating | 2013 |
Voxel-based analysis of amyloid-burden measured with [(11)C]PiB PET in a double transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Animals; Benzothiazoles; Carbon Radioisotopes; Disease Models, Animal; Female; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Positron-Emission Tomography; Regression Analysis; Signal Processing, Computer-Assisted; Thiazoles | 2013 |
Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma.
Topics: Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Density Conservation Agents; Bone Neoplasms; Bone Resorption; Cat Diseases; Cats; Cell Line, Tumor; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Diphosphonates; Disease Models, Animal; Heterografts; Humans; Imidazoles; Male; Meloxicam; Mice; Mice, Nude; Mouth Neoplasms; Neoplasms, Squamous Cell; Random Allocation; Real-Time Polymerase Chain Reaction; RNA, Messenger; Thiazines; Thiazoles; Treatment Outcome; Zoledronic Acid | 2015 |
Synthesis of new N-substituted 5-arylidene-2,4-thiazolidinediones as anti-inflammatory and antimicrobial agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antifungal Agents; Candida albicans; Disease Models, Animal; Gram-Negative Bacteria; Gram-Positive Bacteria; Inflammation; Magnetic Resonance Spectroscopy; Male; Meloxicam; Phagocytes; Rats; Rats, Wistar; Structure-Activity Relationship; Thiazines; Thiazoles; Thiazolidinediones | 2013 |
The role of ventral and dorsal striatum mGluR5 in relapse to cocaine-seeking and extinction learning.
Topics: Allosteric Regulation; Analysis of Variance; Animals; Basal Ganglia; Biotinylation; Blotting, Western; Cocaine; Cocaine-Related Disorders; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Electrophysiological Phenomena; Extinction, Psychological; Infusions, Intravenous; Locomotion; Long-Term Synaptic Depression; Male; Microinjections; Pyridines; Rats; Receptor, Metabotropic Glutamate 5; Recurrence; Self Administration; Sucrose; Thiazoles | 2014 |
Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy.
Topics: Angiogenesis Inhibitors; Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Humans; Oxygen; PPAR delta; PPAR-beta; Rats; Retinal Diseases; Retinal Neovascularization; Retinal Vessels; Sulfones; Thiazoles; Thiophenes | 2013 |
Src inhibitors in suppression of papillary thyroid carcinoma growth.
Topics: Animals; Carcinoma; Carcinoma, Papillary; Cell Proliferation; Dasatinib; Disease Models, Animal; Indoles; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinase 1; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Signal Transduction; src-Family Kinases; Sulfonamides; Thiazoles; Thyroid Cancer, Papillary; Thyroid Neoplasms; Tumor Cells, Cultured | 2014 |
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Electron Transport; Fatty Acids; Humans; Lipid Metabolism; Mice; Mice, Nude; Mice, Transgenic; Mitochondria; Neuroblastoma; Proto-Oncogene Proteins c-myc; Receptor, trkA; Signal Transduction; Thiazoles; Xenograft Model Antitumor Assays | 2013 |
Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Cyclin-Dependent Kinase 5; Diamines; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Learning; Male; Memory; Mice; Mice, Transgenic; Neuroprotective Agents; Phosphorylation; Presenilin-1; Protein Kinase Inhibitors; tau Proteins; Tauopathies; Thiazoles; Treatment Outcome | 2013 |
Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer.
Topics: Animals; Antineoplastic Agents; Biosensing Techniques; Cells, Cultured; Dasatinib; Disease Models, Animal; Fluorescence Resonance Energy Transfer; Imaging, Three-Dimensional; Mice; Mice, Transgenic; Microscopy, Fluorescence; Pancreatic Neoplasms; Pyrimidines; src-Family Kinases; Thiazoles | 2013 |
Comparison of antithrombotic and hemorrhagic effects of edoxaban, a novel factor Xa inhibitor, with unfractionated heparin, dalteparin, lepirudin and warfarin in rats.
Topics: Animals; Anticoagulants; Disease Models, Animal; Dose-Response Relationship, Drug; Factor Xa Inhibitors; Heparin; Hirudins; Male; Pyridines; Rats; Rats, Wistar; Recombinant Proteins; Thiazoles; Thromboembolism; Warfarin | 2013 |
A c-Myc activation sensor-based high-throughput drug screening identifies an antineoplastic effect of nitazoxanide.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Heterografts; High-Throughput Screening Assays; Humans; Mice; Mice, Nude; Molecular Imaging; Neoplasm Transplantation; Nitro Compounds; Proto-Oncogene Proteins c-myc; Thiazoles | 2013 |
Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Gliosis; Humans; Integrases; Membrane Glycoproteins; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Phenotype; Presenilin-1; Thiazoles | 2013 |
Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Female; Fragile X Mental Retardation Protein; Hippocampus; In Vitro Techniques; Kainic Acid; Long-Term Synaptic Depression; Phosphorylation; Pregnancy; Protein Phosphatase 2; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Ribosomal Protein S6 Kinases, 70-kDa; Seizures; Signal Transduction; Subcellular Fractions; Thiazoles | 2013 |
Design, synthesis and anticonvulsant evaluation of N-(benzo[d]thiazol-2-ylcarbamoyl)-2-methyl-4-oxoquinazoline-3(4H)-carbothioamide derivatives: a hybrid pharmacophore approach.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Electroshock; Injections, Intraperitoneal; Mice; Molecular Structure; Quinazolines; Rats; Rats, Wistar; Seizures; Thiazoles; Thioamides | 2013 |
Longitudinal amyloid imaging in mouse brain with 11C-PIB: comparison of APP23, Tg2576, and APPswe-PS1dE9 mouse models of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Autoradiography; Benzothiazoles; Brain; Disease Models, Animal; Female; Longitudinal Studies; Male; Mice; Mice, Transgenic; Positron-Emission Tomography; Thiazoles | 2013 |
Protective effect of a β3-adrenoceptor agonist on bladder function in a rat model of chronic bladder ischemia.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Cholesterol, Dietary; Chronic Disease; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Iliac Artery; Ischemia; Male; Neointima; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-3; Thiazoles; Time Factors; Urinary Bladder; Urinary Bladder, Overactive; Urination; Urodynamics; Vascular System Injuries | 2013 |
Serial measurement of hFABP and high-sensitivity troponin I post-PCI in STEMI: how fast and accurate can myocardial infarct size and no-reflow be predicted?
Topics: Animals; Benzothiazoles; Biomarkers; Coronary Circulation; Disease Models, Animal; Fatty Acid-Binding Proteins; Female; Hemodynamics; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Necrosis; No-Reflow Phenomenon; Predictive Value of Tests; Risk Factors; Staining and Labeling; Swine; Tetrazolium Salts; Thiazoles; Time Factors; Troponin I; Up-Regulation | 2013 |
Neuroprotective effects of the antioxidant action of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride against ischemic neuronal damage in the brain.
Topics: Animals; Antioxidants; Brain Ischemia; Catalase; Disease Models, Animal; Gerbillinae; Glutathione; Glutathione Peroxidase; Hippocampus; Male; Malondialdehyde; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Thiazoles | 2013 |
D-512 and D-440 as novel multifunctional dopamine agonists: characterization of neuroprotection properties and evaluation of in vivo efficacy in a Parkinson's disease animal model.
Topics: Animals; Carotenoids; Disease Models, Animal; Dopamine Agonists; Indoles; Lycopene; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neuroprotective Agents; Oxidopamine; Parkinson Disease; Proto-Oncogene Proteins c-akt; Rats; Thiazoles; Tumor Cells, Cultured | 2013 |
Monitoring neuroprotective effects using positron emission tomography with [11C]ITMM, a radiotracer for metabotropic glutamate 1 receptor.
Topics: Animals; Benzamides; Carbon Radioisotopes; Disease Models, Animal; Infarction, Middle Cerebral Artery; Ligands; Male; Minocycline; Neuroprotective Agents; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Thiazoles | 2013 |
A selective peroxisome proliferator-activated receptor-β/δ agonist attenuates neointimal hyperplasia after wire-mediated arterial injury.
Topics: Animals; Cell Proliferation; Cells, Cultured; Cytokines; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Hyperplasia; Macrophages; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; PPAR delta; PPAR-beta; Regeneration; Thiazoles | 2013 |
Comparison of the effect of edoxaban, a direct factor Xa inhibitor, with a direct thrombin inhibitor, melagatran, and heparin on intracerebral hemorrhage induced by collagenase in rats.
Topics: Animals; Anticoagulants; Antithrombins; Azetidines; Benzylamines; Cerebral Hemorrhage; Collagenases; Disease Models, Animal; Factor Xa Inhibitors; Heparin; Male; Pyridines; Rats; Rats, Wistar; Thiazoles | 2014 |
The orthosteric GABAA receptor ligand Thio-4-PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors.
Topics: Animals; Anxiety; Behavior, Animal; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Partial Agonism; GABA-A Receptor Agonists; HEK293 Cells; Humans; Ligands; Male; Membrane Potentials; Memory; Motor Activity; Nociception; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, GABA; Synapses; Thiazoles; Time Factors; Transfection; Xenopus laevis | 2013 |
Intra-articular anaesthesia mitigates established pain in experimental osteoarthritis: a preliminary study of gait impulse redistribution as a biomarker of analgesia pharmacodynamics.
Topics: Anesthetics, Local; Animals; Anterior Cruciate Ligament Injuries; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthritis, Experimental; Biomarkers; Disease Models, Animal; Dogs; Female; Femoral Fractures; Gait; Injections, Intra-Articular; Injections, Intradermal; Lidocaine; Male; Meloxicam; Osteoarthritis, Knee; Pilot Projects; Thiazines; Thiazoles; Weight-Bearing | 2013 |
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls.
Topics: Age Factors; Aged; Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Aniline Compounds; Animals; Autoradiography; Benzothiazoles; Brain; Brain Mapping; Calcium-Binding Proteins; Carbon Isotopes; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Middle Aged; Mutation; Positron-Emission Tomography; Protein Structure, Secondary; tau Proteins; Tauopathies; Thiazoles | 2013 |
Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid.
Topics: Analgesics; Animals; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Conditioning, Operant; Cues; Discrimination, Psychological; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug-Seeking Behavior; Kynurenic Acid; Male; Memory, Short-Term; Morpholines; Naphthalenes; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reinforcement, Psychology; Saimiri; Secondary Prevention; Self Administration; Substance-Related Disorders; Sulfonamides; Thiazoles; Time Factors; Wakefulness | 2013 |
A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation.
Topics: Allografts; Animals; Atorvastatin; Biopsy; Cohort Studies; Dasatinib; Databases as Topic; Disease Models, Animal; Drug Approval; Electronic Health Records; Gene Expression Regulation; Gene Regulatory Networks; Graft Rejection; Graft Survival; Heart Transplantation; Heptanoic Acids; Humans; Kidney; Kidney Transplantation; Meta-Analysis as Topic; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Organ Specificity; Pyrimidines; Pyrroles; Reproducibility of Results; Retrospective Studies; Thiazoles; Transplantation; United States; United States Food and Drug Administration | 2013 |
IGFBP2/FAK pathway is causally associated with dasatinib resistance in non-small cell lung cancer cells.
Topics: Animals; Antineoplastic Agents; Benzodioxoles; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dasatinib; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Activation; Female; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression; Humans; Inhibitory Concentration 50; Insulin-Like Growth Factor Binding Protein 2; Lung Neoplasms; Mice; Mutation; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Signal Transduction; Thiazoles; Xenograft Model Antitumor Assays | 2013 |
Peroxisome proliferator-activated receptor δ agonist GW1516 attenuates diet-induced aortic inflammation, insulin resistance, and atherosclerosis in low-density lipoprotein receptor knockout mice.
Topics: Animals; Anti-Inflammatory Agents; Aortitis; Atherosclerosis; Biomarkers; Blood Glucose; Cholesterol, Dietary; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Inflammation Mediators; Insulin; Insulin Resistance; Lipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; PPAR delta; Receptors, LDL; Signal Transduction; Thiazoles; Time Factors | 2014 |
Discovery of benzo[d]imidazo[5,1-b]thiazole as a new class of phosphodiesterase 10A inhibitors.
Topics: Animals; Antipsychotic Agents; Disease Models, Animal; Dizocilpine Maleate; Drug Evaluation, Preclinical; Enzyme Activation; Female; Half-Life; Imidazoles; Molecular Docking Simulation; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Psychotic Disorders; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles | 2013 |
The role of metabotropic glutamate receptor 5 on the stromal cell-derived factor-1/CXCR4 system in oral cancer.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chemokine CXCL12; Disease Models, Animal; Gene Expression; Gene Expression Regulation, Neoplastic; Glutamic Acid; Humans; Mice; Mouth Neoplasms; Neoplasm Metastasis; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, CXCR4; Thiazoles | 2013 |
Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases.
Topics: Administration, Oral; Animals; Arthritis, Experimental; Class Ib Phosphatidylinositol 3-Kinase; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Male; Mice; Mice, Inbred DBA; Molecular Structure; Oxadiazoles; Phosphoinositide-3 Kinase Inhibitors; Structure-Activity Relationship; Thiazoles | 2013 |
Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain.
Topics: Amino Acid Transport System X-AG; Animals; Astrocytes; Disease Models, Animal; Drug Administration Routes; Enzyme Inhibitors; Excitatory Amino Acid Transporter 2; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hyperalgesia; Interleukin-1beta; Male; Neurons; Oncogene Protein v-akt; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sciatica; Serine; Spinal Cord; Thiazoles; Time Factors; Urea | 2014 |
Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease.
Topics: Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Gene Expression Profiling; Huntington Disease; Immunoenzyme Techniques; Intranuclear Inclusion Bodies; Mice; Mice, Knockout; Motor Activity; Pyridines; Real-Time Polymerase Chain Reaction; Receptor, Metabotropic Glutamate 5; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins; Thiazoles | 2014 |
Administration of mesenchymal stem cells and ziprasidone enhanced amelioration of ischemic brain damage in rats.
Topics: Animals; Brain Ischemia; Brain-Derived Neurotrophic Factor; Cell Survival; Combined Modality Therapy; Disease Models, Animal; Gene Expression Regulation; Glial Cell Line-Derived Neurotrophic Factor; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Microglia; Nerve Growth Factor; Neural Stem Cells; Neuroprotective Agents; Piperazines; Rats; Rats, Sprague-Dawley; Thiazoles | 2013 |
Increased O-GlcNAcylation reduces pathological tau without affecting its normal phosphorylation in a mouse model of tauopathy.
Topics: Acetylglucosamine; Animals; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Disease Models, Animal; Female; Glycosylation; Male; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; Phosphorylation; Pyrans; tau Proteins; Tauopathies; Thiazoles | 2014 |
The PPARβ/δ agonist GW501516 attenuates peritonitis in peritoneal fibrosis via inhibition of TAK1-NFκB pathway in rats.
Topics: Animals; Cells, Cultured; Chemokine CCL2; Dietary Supplements; Disease Models, Animal; Glucose; I-kappa B Kinase; Inflammation; Interleukin-6; Lipopolysaccharides; Male; MAP Kinase Kinase Kinases; Peritoneal Dialysis; Peritoneal Fibrosis; Peritonitis; PPAR delta; PPAR-beta; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazoles; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Uremia | 2014 |
Selective action of an atypical neuroleptic on the mechanisms related to the development of cocaine addiction: a pre-clinical behavioural study.
Topics: Animals; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Central Nervous System Sensitization; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Antagonists; Dopamine Uptake Inhibitors; Haloperidol; Male; Mice; Motor Activity; Piperazines; Quinolones; Thiazoles | 2014 |
Osseous wound repair under inhibition of the axis of advanced glycation end-products and the advanced glycation end-products receptor.
Topics: Animals; Collagen Type I; Disease Models, Animal; Fibronectins; Glycation End Products, Advanced; Guanidines; Male; Mandibular Injuries; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Thiazoles; Tumor Necrosis Factor-alpha; Wound Healing; X-Ray Microtomography | 2015 |
Thiazolopyridone ureas as DNA gyrase B inhibitors: optimization of antitubercular activity and efficacy.
Topics: Administration, Oral; Animals; Antitubercular Agents; Disease Models, Animal; Inhibitory Concentration 50; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyridones; Thiazoles; Topoisomerase II Inhibitors; Urea | 2014 |
Neuronal inclusions of α-synuclein contribute to the pathogenesis of Krabbe disease.
Topics: alpha-Synuclein; Animals; Benzothiazoles; Brain; Case-Control Studies; Cognition; Disease Models, Animal; Fluorescent Dyes; Humans; Leukodystrophy, Globoid Cell; Lewy Bodies; Mice; Motor Activity; Mutation; Neurons; Psychosine; Thiazoles | 2014 |
Methylglyoxal, a reactive glucose metabolite, increases renin angiotensin aldosterone and blood pressure in male Sprague-Dawley rats.
Topics: Aldosterone; Angiotensins; Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Catecholamines; Cells, Cultured; Disease Models, Animal; Hypertension; Male; NF-kappa B; Pyruvaldehyde; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Renin; Renin-Angiotensin System; RNA Interference; RNA, Messenger; Signal Transduction; Thiazoles; Time Factors; Up-Regulation | 2014 |
Synthesis and anticonvulsant activity evaluation of 7-alkoxy[1,2,4]triazolo[3,4-b]benzothiazol-3(2H)-ones.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; gamma-Aminobutyric Acid; Mice; Neurotoxicity Syndromes; Seizures; Structure-Activity Relationship; Thiazoles | 2014 |
Inhibition of pathological corneal neovascularization by a small peptide derived from human apolipoprotein (a) Kringle V.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal, Humanized; Apoprotein(a); Bevacizumab; Cell Movement; Cell Proliferation; Cells, Cultured; Chick Embryo; Chorioallantoic Membrane; Choroid; Collagen; Corneal Neovascularization; Disease Models, Animal; Drug Combinations; Endothelium, Vascular; Kringles; Laminin; Macaca mulatta; Mice; Mice, Inbred C57BL; Oligopeptides; Proteoglycans; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Vascular Endothelial Growth Factor A | 2014 |
Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model.
Topics: Animals; Antiviral Agents; Cell Line; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Encephalitis Virus, Japanese; Encephalitis, Japanese; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Nitro Compounds; Survival Analysis; Thiazoles; Treatment Outcome; Viral Load; Virus Replication | 2014 |
Structural modifications of neuroprotective anti-Parkinsonian (-)-N6-(2-(4-(biphenyl-4-yl)piperazin-1-yl)-ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine (D-264): an effort toward the improvement of in vivo efficacy of the parent molecule.
Topics: Animals; Benzothiazoles; Biphenyl Compounds; Cell Line; Disease Models, Animal; Mice; Neuroprotective Agents; Parkinson Disease; Piperazines; Rats; Structure-Activity Relationship; Thiazoles | 2014 |
Isothiafludine, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation.
Topics: Animals; Antiviral Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Viral; Ducks; Hep G2 Cells; Hepadnaviridae Infections; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Humans; Mutation; Nucleocapsid; RNA, Viral; Thiazoles; Time Factors; Transfection; Virus Replication | 2014 |
Glutamate prevents intestinal atrophy via luminal nutrient sensing in a mouse model of total parenteral nutrition.
Topics: Animal Nutrition Sciences; Animals; Atrophy; Cell Proliferation; Disease Models, Animal; Down-Regulation; Epithelial Cells; Epithelium; Food; Glucagon-Like Peptide 2; Glutamic Acid; Intestinal Mucosa; Jejunum; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Parenteral Nutrition, Total; Permeability; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, G-Protein-Coupled; Signal Transduction; Thiazoles | 2014 |
The phosphoinositide 3-kinase α selective inhibitor BYL719 enhances the effect of the protein kinase C inhibitor AEB071 in GNAQ/GNA11-mutant uveal melanoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Silencing; GTP-Binding Protein alpha Subunits; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Melanoma; Mice; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Pyrroles; Quinazolines; RNA Interference; Signal Transduction; Thiazoles; Tumor Burden; Uveal Neoplasms; Xenograft Model Antitumor Assays | 2014 |
Involvement of mGlu5 receptor in 3-nitropropionic acid-induced oxidative stress in rat striatum.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Glutathione Peroxidase; Glutathione Reductase; Huntington Disease; Male; Motor Activity; Neuroprotective Agents; Nitro Compounds; Oxidative Stress; Propionates; Pyridines; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Sodium-Potassium-Exchanging ATPase; Succinate Dehydrogenase; Thiazoles; Weight Loss | 2014 |
Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; Humans; Inhibitory Concentration 50; Mice; Mutation; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; PTEN Phosphohydrolase; Rats; Thiazoles; Xenograft Model Antitumor Assays | 2014 |
Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors.
Topics: Animals; Carrageenan; Casein Kinase I; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Humans; Hyperalgesia; Indoles; Inflammation; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Pain; Pain Measurement; Pain Threshold; Phloroglucinol; Protein Transport; Spinal Cord; Thiazoles | 2014 |
Preclinical evaluation of marketed sodium channel blockers in a rat model of myotonia discloses promising antimyotonic drugs.
Topics: Animals; Carbamazepine; Disease Models, Animal; Flecainide; HEK293 Cells; Humans; Mexiletine; Muscle, Skeletal; Myotonia Congenita; Orphenadrine; Piperidines; Propafenone; Rats; Rats, Wistar; Riluzole; Sodium Channel Blockers; Thiazoles | 2014 |
A novel small-molecule tumor necrosis factor α inhibitor attenuates inflammation in a hepatitis mouse model.
Topics: Animals; Blotting, Western; Caspases; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Hepatitis, Animal; HL-60 Cells; Humans; Hydrazones; Inflammation; Jurkat Cells; K562 Cells; MAP Kinase Kinase 4; Mice; Mice, Inbred BALB C; Molecular Structure; Protein Binding; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Surface Plasmon Resonance; Thiazoles; Tumor Necrosis Factor-alpha | 2014 |
A PPAR-β/δ agonist is neuroprotective and decreases cognitive impairment in a rodent model of Parkinson's disease.
Topics: Animals; Blotting, Western; Brain; Cognition; Disease Models, Animal; DNA Fragmentation; In Situ Nick-End Labeling; Male; Maze Learning; Neurons; Neuroprotective Agents; Parkinsonian Disorders; PPAR delta; PPAR-beta; Rats; Rats, Sprague-Dawley; Thiazoles | 2014 |
Development of a lameness model in sheep for assessing efficacy of analgesics.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Irritants; Lameness, Animal; Meloxicam; Pain; Sheep; Sheep Diseases; Thiazines; Thiazoles; Turpentine | 2011 |
A mouse model of mitochondrial complex III dysfunction induced by myxothiazol.
Topics: Animals; Antifungal Agents; Disease Models, Animal; Electron Transport Complex III; Liver; Methacrylates; Mice; Mice, Inbred C57BL; Mitochondria; Thiazoles | 2014 |
Novel small molecules disrupting Hec1/Nek2 interaction ablate tumor progression by triggering Nek2 degradation through a death-trap mechanism.
Topics: Animals; Benzamides; Binding Sites; Cell Line, Tumor; Cytoskeletal Proteins; Disease Models, Animal; Disease Progression; Gene Expression; Heterografts; Humans; Indoles; Inhibitory Concentration 50; Mitosis; Models, Molecular; Molecular Conformation; Neoplasms; NIMA-Related Kinases; Nuclear Proteins; Phosphorylation; Prognosis; Protein Binding; Protein Serine-Threonine Kinases; Proteolysis; Thiazoles; Valerates | 2015 |
Mechanisms of dopamine D1 receptor-mediated ERK1/2 activation in the parkinsonian striatum and their modulation by metabotropic glutamate receptor type 5.
Topics: Adrenergic Agents; Animals; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; In Vitro Techniques; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidopamine; Parkinson Disease; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D1; Thiazoles; Tyrosine 3-Monooxygenase | 2014 |
Xanthine oxidase inhibition by febuxostat attenuates experimental atherosclerosis in mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Body Weight; Cholesterol; Cytokines; Disease Models, Animal; Endothelial Cells; Febuxostat; Gout Suppressants; Inflammation; L-Lactate Dehydrogenase; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Plaque, Atherosclerotic; Reactive Oxygen Species; Thiazoles; Xanthine Oxidase | 2014 |
Host biomarkers of invasive pulmonary aspergillosis to monitor therapeutic response.
Topics: Amphotericin B; Animals; Annexin A1; Antifungal Agents; Aspergillus fumigatus; Biomarkers; Bronchoalveolar Lavage Fluid; C-Reactive Protein; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Invasive Pulmonary Aspergillosis; Neutropenia; Proteomics; Rabbits; Thiazoles; Triazoles | 2014 |
Effects of juvenile exposure to predator odor on adolescent and adult anxiety and pain nociception.
Topics: Age Factors; Animals; Anxiety Disorders; Disease Models, Animal; Electroshock; Fear; Male; Maze Learning; Neuropsychological Tests; Nociception; Odorants; Pain Measurement; Predatory Behavior; Rats, Sprague-Dawley; Stress, Psychological; Thiazoles | 2014 |
A TGF-β receptor 1 inhibitor for prevention of proliferative vitreoretinopathy.
Topics: Animals; Cell Proliferation; Cell Transdifferentiation; Disease Models, Animal; Fibroblasts; Humans; Intravitreal Injections; Protein Serine-Threonine Kinases; Pyrazoles; Pyrroles; Rabbits; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; Retinal Pigment Epithelium; Tenon Capsule; Tetrazolium Salts; Thiazoles; Vitreoretinopathy, Proliferative | 2014 |
Protective role of peroxisome proliferator-activated receptor β/δ in acute lung injury induced by prolonged hyperbaric hyperoxia in rats.
Topics: Acute Lung Injury; Animals; Antioxidants; Apoptosis; Cytokines; Disease Models, Animal; Hyperoxia; Lung; Male; MAP Kinase Signaling System; Neuroprotective Agents; NF-kappa B; PPAR delta; PPAR-beta; Pressure; Random Allocation; Rats, Sprague-Dawley; Respiratory System Agents; Sulfones; Thiazoles; Thiophenes; Time Factors | 2014 |
Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.
Topics: Animals; Azacitidine; Blotting, Western; Bone Marrow Cells; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Dasatinib; Decitabine; Dioxygenases; Disease Models, Animal; DNA-Binding Proteins; Drug Therapy, Combination; Enzyme Inhibitors; Esophagus; Gastric Mucosa; Humans; Mast Cells; Mastocytosis, Systemic; Mice, Knockout; Mice, Transgenic; Mutation, Missense; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Pyrimidines; RNA Interference; Skin; Stomach; Thiazoles | 2014 |
Aspirin but not meloxicam attenuates early atherosclerosis in apolipoprotein E knockout mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apolipoproteins E; Aspirin; Atherosclerosis; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Meloxicam; Mice; Mice, Inbred C57BL; Mice, Knockout; Plaque, Atherosclerotic; Thiazines; Thiazoles | 2014 |
Synthesis and antifilarial activity of chalcone-thiazole derivatives against a human lymphatic filarial parasite, Brugia malayi.
Topics: Animals; Brugia malayi; Chalcone; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Filariasis; Filaricides; Gerbillinae; Male; Molecular Structure; Murinae; Parasitic Sensitivity Tests; Structure-Activity Relationship; Thiazoles | 2014 |
The effect of selective serotonin reuptake inhibitor (SSRI) on pain-related behavior in a rat model of neuropathic pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Calcium-Binding Proteins; Disease Models, Animal; Ganglia, Spinal; Immunohistochemistry; Meloxicam; Microfilament Proteins; Microglia; Neuralgia; Neurons; Paroxetine; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha | 2014 |
Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders.
Topics: Allosteric Regulation; Animals; Anti-Anxiety Agents; Disease Models, Animal; Female; Male; Mental Disorders; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Thiazoles | 2014 |
Effects of nonsteroidal anti-inflammatory meloxicam on stomach, kidney, and liver of rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemical and Drug Induced Liver Injury; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Kidney; Kidney Diseases; Liver; Meloxicam; Metaplasia; Pain; Rats; Rats, Sprague-Dawley; Stomach; Stomach Diseases; Thiazines; Thiazoles; Toxicity Tests | 2016 |
Optimization of pyrrolamide topoisomerase II inhibitors toward identification of an antibacterial clinical candidate (AZD5099).
Topics: Adenosine Triphosphatases; Amides; Animals; Anti-Bacterial Agents; Crystallography, X-Ray; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Knockout; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Pyrroles; Rats; Rats, Wistar; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship; Thiazoles; Topoisomerase II Inhibitors | 2014 |
The Yersinia pestis siderophore, yersiniabactin, and the ZnuABC system both contribute to zinc acquisition and the development of lethal septicaemic plague in mice.
Topics: Animals; ATP-Binding Cassette Transporters; Disease Models, Animal; Mice; Phenols; Plague; Sepsis; Thiazoles; Virulence; Virulence Factors; Yersinia pestis; Zinc | 2014 |
N-Phenacylthiazolium bromide inhibits the advanced glycation end product (AGE)-AGE receptor axis to modulate experimental periodontitis in rats.
Topics: Alveolar Bone Loss; Animals; Blood Glucose; Cell Adhesion Molecules; Cell Culture Techniques; Cell Line; Cell Survival; Collagen Type I; Disease Models, Animal; Disease Progression; Fibronectins; Glycated Hemoglobin; Glycation End Products, Advanced; Humans; Immunohistochemistry; Male; Periodontal Ligament; Periodontitis; Rats; Rats, Sprague-Dawley; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles; Tumor Necrosis Factor-alpha | 2014 |
Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models.
Topics: Animals; Brain; Cell Survival; Cells, Cultured; Disease Models, Animal; Guanosine Triphosphate; Humans; Inflammation; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Lipopolysaccharides; Mice; Mice, Transgenic; Microglia; Mutation; Neurons; Parkinson Disease; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Sulfones; Thiazoles | 2014 |
Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression.
Topics: 2-Aminoadipic Acid; Animals; Antidepressive Agents; Astrocytes; Depression; Disease Models, Animal; Male; Motor Activity; Prefrontal Cortex; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Thiazoles | 2014 |
ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway.
Topics: ADAM Proteins; Adenocarcinoma; Adenocarcinoma of Lung; Animals; Antigens, CD; Antigens, Neoplasm; Brain Neoplasms; Cell Adhesion Molecules; Cell Line, Tumor; Dasatinib; Dexamethasone; Disease Models, Animal; Gene Knockdown Techniques; Heterografts; Humans; Lung Neoplasms; Membrane Proteins; Mice; Mice, SCID; Neoplasm Metastasis; Neoplasm Proteins; Plasminogen Activators; Pyrimidines; Thiazoles | 2014 |
Novel mGluR5 positive allosteric modulator improves functional recovery, attenuates neurodegeneration, and alters microglial polarization after experimental traumatic brain injury.
Topics: Allosteric Regulation; Animals; Brain Injuries; Cell Count; Cerebral Cortex; Disease Models, Animal; Glycine; Hippocampus; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Microglia; Motor Activity; NADPH Oxidase 2; NADPH Oxidases; Neuroprotective Agents; Nitric Oxide Synthase Type II; Phenylacetates; Pyridines; Receptor, Metabotropic Glutamate 5; Recovery of Function; Thiazoles | 2014 |
Age-dependent suppression of hippocampal epileptic afterdischarges by metabotropic glutamate receptor 5 antagonist MTEP.
Topics: Age Factors; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Complex Partial; Hippocampus; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Thiazoles | 2014 |
Effects of lurasidone on ketamine-induced joint visual attention dysfunction as a possible disease model of autism spectrum disorders in common marmosets.
Topics: Animals; Antipsychotic Agents; Attention Deficit Disorder with Hyperactivity; Callithrix; Child Development Disorders, Pervasive; Cues; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Isoindoles; Ketamine; Lurasidone Hydrochloride; Male; Severity of Illness Index; Thiazoles | 2014 |
Treatment of venous thrombosis with an oral direct factor Xa inhibitor edoxaban by single and multiple administrations in rats.
Topics: Administration, Oral; Animals; Anticoagulants; Antithrombin III; Disease Models, Animal; Drug Administration Schedule; Enoxaparin; Factor Xa Inhibitors; Fondaparinux; Male; Peptide Hydrolases; Polysaccharides; Pyridines; Rats; Rats, Wistar; Thiazoles; Venous Thrombosis | 2014 |
Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Benzothiazoles; Disease Models, Animal; Entorhinal Cortex; Female; Habituation, Psychophysiologic; Hippocampus; Male; Memory; Mice, Transgenic; Odorants; Olfactory Bulb; Olfactory Pathways; Piriform Cortex; Thiazoles | 2014 |
The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Brain; Cell Culture Techniques; Cell Line; Cricetinae; Disease Models, Animal; Humans; Kinetics; Mice; Mice, Inbred C57BL; Mutagenesis; Mutation; Neurons; Peptide Fragments; Solubility; Thermodynamics; Thiazoles | 2014 |
Peroxisome proliferator-activated receptor δ promotes the progression of posttraumatic osteoarthritis in a mouse model.
Topics: Animals; Cartilage, Articular; Cells, Cultured; Chondrocytes; Disease Models, Animal; Disease Progression; Glycosaminoglycans; In Vitro Techniques; Menisci, Tibial; Mice; Mice, Inbred Strains; Mice, Knockout; Osteoarthritis, Knee; PPAR delta; Severity of Illness Index; Thiazoles; Wounds and Injuries | 2015 |
Involvement of cholinergic system in hyperactivity in dopamine-deficient mice.
Topics: Acetylcholine; Akathisia, Drug-Induced; Animals; Anti-Dyskinesia Agents; Antipsychotic Agents; Central Nervous System Stimulants; Choline O-Acetyltransferase; Clozapine; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agents; Extracellular Space; Haloperidol; Levodopa; Locomotion; Mice, Inbred C57BL; Piperazines; Psychomotor Agitation; Thiazoles | 2015 |
Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Benzothiazoles; Brain; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; Female; Longitudinal Studies; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Multimodal Imaging; Perfusion Imaging; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2014 |
Binding of the PET radiotracer [¹⁸F]BF227 does not reflect the presence of alpha-synuclein aggregates in transgenic mice.
Topics: alpha-Synuclein; Animals; Benzoxazoles; Brain Stem; Disease Models, Animal; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Positron-Emission Tomography; Radioligand Assay; Tauopathies; Thalamus; Thiazoles | 2014 |
Abberant protein synthesis in G2019S LRRK2 Drosophila Parkinson disease-related phenotypes.
Topics: Animals; Disease Models, Animal; Drosophila; Drosophila Proteins; Drug Evaluation, Preclinical; Hydrazones; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Parkinson Disease; Phenotype; Protein Biosynthesis; Protein Serine-Threonine Kinases; Ribosomal Proteins; Thiazoles | 2014 |
Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL.
Topics: ADP-Ribosylation Factor 1; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Dasatinib; Dexamethasone; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Humans; Interleukin-7; Janus Kinases; Male; Mice; Mice, Inbred C57BL; Mutation; Neoplasm Recurrence, Local; Nitriles; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrazoles; Pyrimidines; Real-Time Polymerase Chain Reaction; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Survival Rate; Thiazoles; Tumor Cells, Cultured | 2015 |
Inhibitors of SRC kinases impair antitumor activity of anti-CD20 monoclonal antibodies.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antibody-Dependent Cell Cytotoxicity; Antigens, CD20; Blotting, Western; Cell Line, Tumor; Dasatinib; Disease Models, Animal; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Humans; K562 Cells; Killer Cells, Natural; Mice, Inbred C57BL; Neoplasms; Oligonucleotide Array Sequence Analysis; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Rituximab; Signal Transduction; src-Family Kinases; Thiazoles; Transcriptome | 2014 |
TMT predator odor activated neural circuit in C57BL/6J mice indicates TMT-stress as a suitable model for uncontrollable intense stress.
Topics: Animals; Anxiety; Brain; Cell Count; Diethylhexyl Phthalate; Disease Models, Animal; Immunohistochemistry; Male; Mice, Inbred C57BL; Neural Pathways; Neurons; Odorants; Physical Stimulation; Predatory Behavior; Proto-Oncogene Proteins c-fos; Stress, Psychological; Thiazoles | 2015 |
Utilization of spray drying technique for improvement of dissolution and anti-inflammatory effect of Meloxicam.
Topics: Aerosols; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buffers; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Crystallography, X-Ray; Desiccation; Disease Models, Animal; Excipients; Formaldehyde; Hydrogen-Ion Concentration; Kinetics; Male; Meloxicam; Microscopy, Electron, Scanning; Pain; Particle Size; Rats, Wistar; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; Thiazines; Thiazoles; Water | 2015 |
SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes.
Topics: Angiopoietin-Like Protein 8; Angiopoietin-like Proteins; Anilides; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Activation; Enzyme Activators; Hepatocytes; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin-Secreting Cells; Male; Mice, Mutant Strains; Obesity; Peptide Hormones; Signal Transduction; Sirtuin 1; Thiazoles; Time Factors; Torpor | 2015 |
Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cell Adhesion Molecules; Cells, Cultured; Complement C1q; Complement C3; Disease Models, Animal; Embryo, Mammalian; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Phosphopyruvate Hydratase; PPAR delta; Thiazoles | 2015 |
Primary tumour growth in an orthotopic osteosarcoma mouse model is not influenced by analgesic treatment with buprenorphine and meloxicam.
Topics: Analgesics, Opioid; Animal Welfare; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Neoplasms; Buprenorphine; Disease Models, Animal; Drug Therapy, Combination; Female; Injections; Longevity; Lung Neoplasms; Meloxicam; Mice; Mice, SCID; Osteosarcoma; Pain Management; Thiazines; Thiazoles; Tibia | 2015 |
The effect of estrogen-related receptor α on the regulation of angiogenesis after spinal cord injury.
Topics: Angiogenesis Inhibitors; Angiopoietin-2; Animals; Cell Proliferation; Disease Models, Animal; Endothelial Cells; ERRalpha Estrogen-Related Receptor; Male; Neovascularization, Pathologic; Nitriles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Random Allocation; Rats, Sprague-Dawley; Receptors, Estrogen; Spinal Cord Injuries; Thiazoles; Transcription Factors; Vascular Endothelial Growth Factor A | 2015 |
Role of spinal metabotropic glutamate receptor 5 in pudendal inhibition of the nociceptive bladder reflex in cats.
Topics: Acetic Acid; Action Potentials; Animals; Cats; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Male; Muscle Contraction; Muscle, Smooth; Nerve Fibers, Unmyelinated; Neural Inhibition; Nociception; Nociceptors; Pudendal Nerve; Pyridines; Receptor, Metabotropic Glutamate 5; Reflex; Signal Transduction; Spinal Cord Injuries; Spinal Nerves; Thiazoles; Thoracic Vertebrae; Time Factors; Urinary Bladder; Urinary Bladder, Overactive; Urodynamics | 2015 |
The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects.
Topics: Actins; Aniline Compounds; Animals; Cardiomegaly; Disease Models, Animal; Fibrosis; Gene Expression Regulation; Lipids; Lipogenesis; Liver X Receptors; Mice; Mice, Inbred C57BL; Organ Size; Orphan Nuclear Receptors; Reverse Transcriptase Polymerase Chain Reaction; Smad2 Protein; Smad3 Protein; Thiazoles; Transforming Growth Factor beta; Up-Regulation | 2015 |
Preclinical Comparison of the Amyloid-β Radioligands [(11)C]Pittsburgh compound B and [(18)F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral Amyloidosis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Disease Models, Animal; Immunohistochemistry; Mice; Positron-Emission Tomography; Radiopharmaceuticals; Stilbenes; Thiazoles | 2015 |
Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination.
Topics: Acrylamides; Active Transport, Cell Nucleus; Animals; Axons; Cell Nucleus; Cells, Cultured; Disease Models, Animal; Disease Progression; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Exportin 1 Protein; Female; Karyopherins; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroprotective Agents; Proteomics; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Thiazoles; Treatment Outcome | 2015 |
Activation of PPARδ signaling improves skeletal muscle oxidative metabolism and endurance function in an animal model of ischemic left ventricular dysfunction.
Topics: Adenosine Triphosphate; Animals; Cell Line; Disease Models, Animal; Energy Metabolism; Exercise Tolerance; Fatty Acids; Heart Failure; Mice, Inbred C57BL; Muscle Strength; Muscle, Skeletal; Myocardial Infarction; Oxidation-Reduction; Physical Endurance; PPAR gamma; Signal Transduction; Thiazoles; Time Factors; Transcription, Genetic; Ventricular Dysfunction, Left; Ventricular Function, Left | 2015 |
Copaiba oil effect on experimental jaw defect in Wistar rats.
Topics: Adipose Tissue; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Regeneration; Bone Substitutes; Ceramics; Disease Models, Animal; Fabaceae; Jaw; Jaw Abnormalities; Male; Meloxicam; Osteoblasts; Osteoclasts; Osteogenesis; Plant Oils; Rats, Wistar; Reproducibility of Results; Thiazines; Thiazoles; Time Factors; Treatment Outcome; Wound Healing | 2015 |
Protective effects of rosuvastatin in a rat model of lung contusion: Stimulation of the cyclooxygenase 2-prostaglandin E-2 pathway.
Topics: Acute Lung Injury; Animals; Bronchoalveolar Lavage Fluid; Contusions; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Drug Evaluation, Preclinical; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lung; Male; Meloxicam; Pyrimidines; Random Allocation; Rats; Rosuvastatin Calcium; Sulfonamides; Thiazines; Thiazoles | 2015 |
Vision maintenance and retinal apoptosis reduction in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation.
Topics: Aniline Compounds; Animals; Apoptosis; Disease Models, Animal; Electroretinography; Male; Polyethylene; Rats; Rats, Wistar; Retinal Dystrophies; Thiazoles; Visual Prosthesis | 2015 |
Protease-activated receptor 2 activation is sufficient to induce the transition to a chronic pain state.
Topics: Animals; Azepines; Behavior, Animal; Benzamides; Brain-Derived Neurotrophic Factor; Butadienes; Chronic Pain; Dinoprostone; Disease Models, Animal; Facial Expression; Hydrazones; Hyperalgesia; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nitriles; Protein Kinase C; Receptor, PAR-2; Receptor, trkB; Signal Transduction; Thiazoles | 2015 |
SKI-II--a sphingosine kinase 1 inhibitor--exacerbates atherosclerosis in low-density lipoprotein receptor-deficient (LDL-R-/-) mice on high cholesterol diet.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Atherosclerosis; Biomarkers; Cholesterol, Dietary; Cholesterol, HDL; Diet, Western; Disease Models, Animal; Enzyme Inhibitors; Female; Hypercholesterolemia; Intercellular Adhesion Molecule-1; Lysophospholipids; Mice, Knockout; Phosphotransferases (Alcohol Group Acceptor); Receptors, LDL; Risk Factors; Sphingosine; Thiazoles; Time Factors; Triglycerides; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2015 |
Pseudomonas aeruginosa wound infection involves activation of its iron acquisition system in response to fascial contact.
Topics: Abdominal Muscles; Animals; Disease Models, Animal; Fascia; Gene Expression Profiling; Mice; Mice, Inbred C57BL; Microarray Analysis; Phenols; Pseudomonas aeruginosa; Pseudomonas Infections; Surgical Wound Infection; Thiazoles; Virulence | 2015 |
The AMPK Agonist PT1 and mTOR Inhibitor 3HOI-BA-01 Protect Cardiomyocytes After Ischemia Through Induction of Autophagy.
Topics: AMP-Activated Protein Kinases; Animals; Animals, Newborn; Apoptosis; Autophagy; Benzodioxoles; Cell Hypoxia; Cells, Cultured; Cytoprotection; Disease Models, Animal; Glucose; Indoles; Male; meta-Aminobenzoates; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxygen; Protein Kinase Inhibitors; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases | 2016 |
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Drug Design; Edema; Humans; Inflammation; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Naproxen; Nociception; Pain; Pain Measurement; Structure-Activity Relationship; Thiazoles; Thiones; Triazoles | 2015 |
Engagement of the GABA to KCC2 signaling pathway contributes to the analgesic effects of A3AR agonists in neuropathic pain.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; HEK293 Cells; Humans; Hyperalgesia; K Cl- Cotransporters; Male; Mice; Pain Threshold; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sciatica; Signal Transduction; Spinal Nerve Roots; Symporters; Thiazoles; Thioglycolates | 2015 |
Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Axl Receptor Tyrosine Kinase; Benzoates; Benzylamines; Bexarotene; c-Mer Tyrosine Kinase; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Leukocyte Common Antigens; Macrophages; Male; Membrane Glycoproteins; Mice; Microglia; Myeloid Cells; Phagocytosis; Pioglitazone; Plaque, Amyloid; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones | 2015 |
KCC2 function modulates in vitro ictogenesis.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bumetanide; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy; Excitatory Amino Acid Antagonists; K Cl- Cotransporters; Male; Rats, Sprague-Dawley; Sodium Potassium Chloride Symporter Inhibitors; Symporters; Thiazoles; Thiazolidines; Thioglycolates; Tissue Culture Techniques | 2015 |
Inhibition of PI3K Pathway Reduces Invasiveness and Epithelial-to-Mesenchymal Transition in Squamous Lung Cancer Cell Lines Harboring PIK3CA Gene Alterations.
Topics: Aminopyridines; Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Epithelial-Mesenchymal Transition; Humans; Imidazoles; Lung Neoplasms; Morpholines; Mutation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Signal Transduction; Thiazoles; Xenograft Model Antitumor Assays | 2015 |
BMI1 is expressed in canine osteosarcoma and contributes to cell growth and chemotherapy resistance.
Topics: Adolescent; Animals; Antineoplastic Agents; Bone Neoplasms; Carboplatin; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dogs; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Humans; Male; Osteosarcoma; Polycomb Repressive Complex 1; Thiazoles | 2015 |
PPARβ/δ Agonist Provides Neuroprotection by Suppression of IRE1α-Caspase-12-Mediated Endoplasmic Reticulum Stress Pathway in the Rotenone Rat Model of Parkinson's Disease.
Topics: Animals; Apoptosis; Caspase 12; Disease Models, Animal; Dopamine; Dopaminergic Neurons; Endoplasmic Reticulum Stress; Endoribonucleases; Fluorescent Antibody Technique; Male; Motor Activity; Multienzyme Complexes; Neostriatum; Neuroprotection; Parkinson Disease; PPAR delta; PPAR-beta; Protein Serine-Threonine Kinases; Rats, Sprague-Dawley; Rotenone; Signal Transduction; Thiazoles | 2016 |
Development of a Transgenic Mouse with R124H Human TGFBI Mutation Associated with Granular Corneal Dystrophy Type 2.
Topics: Alleles; Animals; Base Sequence; Benzothiazoles; Corneal Dystrophies, Hereditary; Disease Models, Animal; DNA Primers; DNA, Complementary; Female; Genotype; Heterozygote; Homozygote; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Microscopy, Electron; Microtubule-Associated Proteins; Mutation; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Transforming Growth Factor beta1 | 2015 |
Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Carbon-13 Magnetic Resonance Spectroscopy; Disease Models, Animal; Drug Monitoring; Fluorescent Dyes; Humans; Mice, Transgenic; Molecular Imaging; Photons; Presenilin-1; Proton Magnetic Resonance Spectroscopy; Spectrometry, Fluorescence; Spectroscopy, Near-Infrared; Thiazoles; Tissue Extracts; Titrimetry | 2015 |
Urinary Bladder Dysfunction in Transgenic Sickle Cell Disease Mice.
Topics: Acetanilides; Adenosine Triphosphate; Anemia, Sickle Cell; Animals; Atropine; Calcium Chloride; Carbachol; Disease Models, Animal; Diuresis; Electric Stimulation; Hemoglobin, Sickle; Humans; Isoproterenol; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Contraction; Muscle, Smooth; Phenylephrine; Potassium Chloride; Thiazoles; Urethra; Urinary Bladder | 2015 |
Intracoronary Infusion of Thioflavin-S to Study Microvascular Obstruction in a Model of Myocardial Infarction.
Topics: Animals; Benzothiazoles; Coronary Angiography; Coronary Circulation; Coronary Occlusion; Coronary Vessels; Disease Models, Animal; Fluorescent Dyes; Infusions, Intra-Arterial; Microcirculation; Microvessels; Myocardial Infarction; Myocardial Reperfusion Injury; Photography; Sus scrofa; Swine; Thiazoles; Ultraviolet Rays | 2015 |
Orally bioavailable Syk inhibitors with activity in a rat PK/PD model.
Topics: Administration, Oral; Animals; Biological Availability; Disease Models, Animal; Dose-Response Relationship, Drug; Intracellular Signaling Peptides and Proteins; Microsomes, Liver; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Structure-Activity Relationship; Syk Kinase; Thiazoles | 2015 |
[CARDIOPROTFETIVE EFECTS OF NECROSTATIN-7 IN THE RAT MODEL OF PERMANENT CORONARY OCCLUSION].
Topics: Animals; Apoptosis; Autophagy; Cicatrix; Coronary Vessels; Disease Models, Animal; Heart Ventricles; Male; Myocardial Infarction; Natriuretic Peptide, Brain; Peptide Fragments; Rats, Wistar; Thiazoles; Ventricular Remodeling | 2015 |
Hippocampal PPARδ Overexpression or Activation Represses Stress-Induced Depressive Behaviors and Enhances Neurogenesis.
Topics: Animals; Cell Differentiation; Depression; Disease Models, Animal; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Hindlimb Suspension; Hippocampus; Male; Mice; Mice, Inbred ICR; Neural Stem Cells; Neurogenesis; Phosphopyruvate Hydratase; PPAR delta; Sincalide; Stress, Psychological; Thiazoles; Time Factors; Transduction, Genetic | 2015 |
Prophylactic Effect of BIO-1211 Small-Molecule Antagonist of VLA-4 in the EAE Mouse Model of Multiple Sclerosis.
Topics: Animals; Blood-Brain Barrier; CD11b Antigen; Cell Movement; Cerebral Cortex; Cytokines; Disease Models, Animal; Disease Progression; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Inflammation Mediators; Integrin alpha4beta1; Leukocyte Common Antigens; Leukocytes; Male; Mice; Monocytes; Multiple Sclerosis; Nitro Compounds; Oligopeptides; Permeability; RNA, Messenger; Thiazoles | 2015 |
Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Benzothiazoles; Brain; Disease Models, Animal; Female; Male; Mice, Transgenic; Microglia; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2015 |
Loss of Metabotropic Glutamate Receptor 5 Function on Peripheral Benzodiazepine Receptor in Mice Prenatally Exposed to LPS.
Topics: Animals; Benzamides; Disease Models, Animal; Encephalitis; Female; Immunoblotting; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroglia; Pregnancy; Prenatal Exposure Delayed Effects; Pyrazoles; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, GABA-A; Thiazoles | 2015 |
N-adamantyl-4-methylthiazol-2-amine suppresses lipopolysaccharide-induced brain inflammation by regulating NF-κB signaling in mice.
Topics: Adamantane; Analysis of Variance; Animals; Anti-Inflammatory Agents; Brain; Brain-Derived Neurotrophic Factor; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Encephalitis; Female; Gene Expression Regulation; Interleukin-1beta; Lipopolysaccharides; Malondialdehyde; Membrane Proteins; Mice; Mice, Inbred C57BL; Nitric Oxide; Prostaglandins E; Superoxide Dismutase; Thiazoles; Tumor Necrosis Factor-alpha | 2015 |
Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease.
Topics: Animals; Anti-Inflammatory Agents; Blood Glucose; Cytoprotection; Diet, High-Fat; Disease Models, Animal; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Inflammasomes; Inflammation Mediators; Lipopolysaccharides; Liver; Male; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Oxidative Stress; Palmitic Acid; PPAR delta; Signal Transduction; Thiazoles; Time Factors | 2015 |
Acute Blockage of Notch Signaling by DAPT Induces Neuroprotection and Neurogenesis in the Neonatal Rat Brain After Stroke.
Topics: Animals; Animals, Newborn; Brain Infarction; Diamines; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; In Situ Nick-End Labeling; Male; Neurogenesis; Neuroprotective Agents; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Receptors, Notch; RNA, Messenger; Signal Transduction; Stroke; Thiazoles | 2016 |
Anti-inflammatory effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in neuronal cultures of dorsal root ganglia and myelinating cells of the peripheral nervous system.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Borrelia burgdorferi; Cell Culture Techniques; Cytokines; Dexamethasone; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Ganglia, Spinal; Humans; In Situ Nick-End Labeling; Inflammation; Lyme Neuroborreliosis; Macaca mulatta; Meloxicam; Microscopy, Confocal; Neurons; Schwann Cells; Thiazines; Thiazoles | 2015 |
Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer.
Topics: Animals; Antineoplastic Agents; Chemokines; Colitis; Colorectal Neoplasms; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Myeloid Differentiation Factor 88; Piperazines; Protein Multimerization; Real-Time Polymerase Chain Reaction; Signal Transduction; Thiazoles | 2016 |
Disease specific modeling: Simulation of the pharmacokinetics of meloxicam and ibuprofen in disease state vs. healthy conditions.
Topics: Animals; Computer Simulation; Disease Models, Animal; Humans; Ibuprofen; Meloxicam; Rats; Tablets; Thiazines; Thiazoles | 2016 |
Investigations on GSK-3β/NF-kB signaling in stress and stress adaptive behavior in electric foot shock subjected mice.
Topics: Adaptation, Psychological; Adjuvants, Immunologic; Animals; Brain; Corticosterone; Disease Models, Animal; Ditiocarb; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; Exploratory Behavior; Gene Expression Regulation; Glycogen Synthase Kinase 3 beta; Interpersonal Relations; Locomotion; Mice; NF-kappa B; Signal Transduction; Stress, Psychological; Thiazoles; Urea | 2016 |
Visualization of microbleeds with optical histology in mouse model of cerebral amyloid angiopathy.
Topics: Animals; Benzothiazoles; Carbocyanines; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; Fluorescent Dyes; Genetic Predisposition to Disease; Imaging, Three-Dimensional; Mice, Transgenic; Microcirculation; Microscopy, Confocal; Microvessels; Optical Imaging; Plaque, Amyloid; Staining and Labeling; Thiazoles | 2016 |
The Yersiniabactin-Associated ATP Binding Cassette Proteins YbtP and YbtQ Enhance Escherichia coli Fitness during High-Titer Cystitis.
Topics: Animals; ATP-Binding Cassette Transporters; Bacterial Proteins; Cystitis; Disease Models, Animal; Escherichia coli; Female; Gene Deletion; Genetic Complementation Test; Mice, Inbred C3H; Phenols; Siderophores; Thiazoles; Virulence Factors | 2016 |
Increased TMEM16A Involved in Alveolar Fluid Clearance After Lipopolysaccharide Stimulation.
Topics: Acute Lung Injury; Animals; Anoctamin-1; Bronchoalveolar Lavage Fluid; Cell Line, Tumor; Chloride Channels; Disease Models, Animal; Lipopolysaccharides; Lung; Male; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Pulmonary Alveoli; Pulmonary Edema; Pyrimidines; RNA Interference; RNA, Small Interfering; Signal Transduction; Thiazoles | 2016 |
Meloxicam-loaded nanocapsules as an alternative to improve memory decline in an Alzheimer's disease model in mice: involvement of Na(+), K(+)-ATPase.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Cerebral Cortex; Cyclooxygenase 2; Disease Models, Animal; Hippocampus; Meloxicam; Memory; Memory Disorders; Mice; Nanocapsules; Sodium-Potassium-Exchanging ATPase; Thiazines; Thiazoles | 2016 |
PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS.
Topics: Anilides; Animals; Disease Models, Animal; Enzyme Activation; Female; Immunity, Innate; Mice; Sepsis; Sirtuin 1; Streptococcal Infections; Streptococcus pneumoniae; Thiazoles; Transcription, Genetic | 2016 |
Prostaglandin-targeting agents and spectral heart rate variability in experimental partial bladder outlet obstruction in rats.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Dinoprost; Disease Models, Animal; Heart Rate; Meloxicam; Molecular Targeted Therapy; Piroxicam; Prostaglandin Antagonists; Prostaglandins; Prostaglandins, Synthetic; Rats; Rats, Wistar; Thiazines; Thiazoles; Urinary Bladder Neck Obstruction; Urodynamics | 2016 |
Antinociceptive Interactions Between Meloxicam and Gabapentin in Neuropathic Pain Depend on the Ratio used in Combination in Rats.
Topics: Amines; Analgesics; Animals; Area Under Curve; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Male; Meloxicam; Neuralgia; Rats; Thiazines; Thiazoles; Treatment Outcome | 2016 |
Synthesis and anticonvulsant activities of novel 2-(cyclopentylmethylene)hydrazinyl-1,3-thiazoles in mouse models of seizures.
Topics: Animals; Anticonvulsants; Carbon-13 Magnetic Resonance Spectroscopy; Disease Models, Animal; Male; Mass Spectrometry; Mice; Pilocarpine; Proton Magnetic Resonance Spectroscopy; Rotarod Performance Test; Seizures; Thiazoles | 2016 |
Anti-Inflammatory Effect of Dexamethasone Controlled Released From Anterior Suprachoroidal Polyurethane Implants on Endotoxin-Induced Uveitis in Rats.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cell Survival; Ciliary Body; Coloring Agents; Cytokines; Dexamethasone; Disease Models, Animal; Drug Delivery Systems; Drug Implants; Extracellular Space; Female; Humans; Iris; Lipopolysaccharides; Polyurethanes; Rats; Rats, Inbred Lew; Retinal Pigment Epithelium; Salmonella typhimurium; Spectroscopy, Fourier Transform Infrared; Tetrazolium Salts; Thiazoles; Uveitis | 2016 |
Inhibition of the Nuclear Receptor RORγ and Interleukin-17A Suppresses Neovascular Retinopathy: Involvement of Immunocompetent Microglia.
Topics: Angiogenesis Inhibitors; Animals; Antibodies, Monoclonal; Cells, Cultured; Digoxin; Disease Models, Animal; Ependymoglial Cells; Hyperoxia; Interleukin-17; Mice, Inbred C57BL; Microglia; Nuclear Receptor Subfamily 1, Group F, Member 3; Placenta Growth Factor; Rats, Sprague-Dawley; Retina; Retinal Ganglion Cells; Retinal Neovascularization; Retinopathy of Prematurity; Signal Transduction; Sulfonamides; Thiazoles; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2016 |
Pulmonary Administration of GW0742, a High-Affinity Peroxisome Proliferator-Activated Receptor Agonist, Repairs Collapsed Alveoli in an Elastase-Induced Mouse Model of Emphysema.
Topics: Animals; Disease Models, Animal; Forced Expiratory Volume; Lung; Mice; Pancreatic Elastase; PPAR delta; PPAR-beta; Pulmonary Emphysema; Pulmonary Surfactant-Associated Protein A; Pulmonary Surfactant-Associated Protein B; Thiazoles; Vital Capacity | 2016 |
Matrix metalloproteinases are possible targets in monocrotaline-induced pulmonary hypertension: investigation of anti-remodeling effects of alagebrium and everolimus.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Everolimus; Hypertension, Pulmonary; Male; Matrix Metalloproteinases; Monocrotaline; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Thiazoles; Vasodilator Agents | 2017 |
Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Cell Line, Tumor; Ceruletide; Chondrocytes; Disease Models, Animal; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Nociception; Pain; Pancreatitis, Acute Necrotizing; Primary Cell Culture; Rats; Swine; Thiazoles; Trigeminal Ganglion; TRPA1 Cation Channel; TRPV Cation Channels | 2016 |
Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Topics: Allosteric Regulation; Allosteric Site; Animals; Antineoplastic Agents; Benzeneacetamides; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Cetuximab; Disease Models, Animal; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Lung Neoplasms; Mice; Mutant Proteins; Protein Conformation; Protein Kinase Inhibitors; Protein Multimerization; Thiazoles | 2016 |
p38 MAPK Inhibition Improves Synaptic Plasticity and Memory in Angiotensin II-dependent Hypertensive Mice.
Topics: Angiotensin II; Animals; Dendritic Spines; Disease Models, Animal; Hippocampus; Humans; Hypertension; Imidazoles; Long-Term Potentiation; Mice; Neuronal Plasticity; p38 Mitogen-Activated Protein Kinases; Pyramidal Cells; Signal Transduction; Thiazoles | 2016 |
Coagulation Factor Xa and Protease-Activated Receptor 2 as Novel Therapeutic Targets for Diabetic Nephropathy.
Topics: Animals; Anti-Inflammatory Agents; Blood Coagulation; Cell Line; Cytokines; Diabetic Nephropathies; Disease Models, Animal; Endothelial Cells; Factor Xa; Factor Xa Inhibitors; Genotype; Humans; Inflammation Mediators; Insulin; Kidney Glomerulus; Macrophages; Male; Mice, Knockout; Nitric Oxide Synthase Type III; Phenotype; Podocytes; Pyridines; Receptor, PAR-2; Signal Transduction; Thiazoles; Up-Regulation | 2016 |
Pharmacokinetics and pharmacodynamics of glycyrrhetinic acid with Paeoniflorin after transdermal administration in dysmenorrhea model mice.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Drug Synergism; Drugs, Chinese Herbal; Dysmenorrhea; Female; Glucosides; Glycyrrhetinic Acid; Meloxicam; Mice; Monoterpenes; Skin Absorption; Thiazines; Thiazoles; Tissue Distribution; Transdermal Patch | 2016 |
Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Glycogen Synthase Kinase 3; Hippocampus; Humans; Learning Disabilities; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA; Thiazoles; Thyroid Nuclear Factor 1; Urea; Vesicular Acetylcholine Transport Proteins | 2017 |
Beta-3 adrenergic agonists reduce pulmonary vascular resistance and improve right ventricular performance in a porcine model of chronic pulmonary hypertension.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Blotting, Western; Disease Models, Animal; Female; Humans; Hypertension, Pulmonary; Immunohistochemistry; Male; Nebivolol; Pulmonary Artery; Random Allocation; Real-Time Polymerase Chain Reaction; Receptors, Adrenergic, beta-3; Swine; Thiazoles; Vascular Resistance; Ventricular Remodeling | 2016 |
Intranasal Administration of a Polyethylenimine-Conjugated Scavenger Peptide Reduces Amyloid-β Accumulation in a Mouse Model of Alzheimer's Disease.
Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Benzothiazoles; Cell Line, Tumor; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Mutation; Neuroblastoma; Peptide Fragments; Polyethyleneimine; Positron-Emission Tomography; Presenilin-1; Thiazoles | 2016 |
Antibacterial and Solubility Optimization of Thiomuracin A.
Topics: Animals; Anti-Bacterial Agents; Clostridioides difficile; Clostridium Infections; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Mice; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; Peptides, Cyclic; Solubility; Structure-Activity Relationship; Thiazoles | 2016 |
Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzothiazoles; Biomarkers; Blotting, Western; Cell Line, Tumor; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Immunohistochemistry; Liver; Male; Mice; Middle Aged; Plaque, Amyloid; Receptor, Notch1; tau Proteins; Thiazoles | 2016 |
Combined treatment with a β
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Cold Temperature; Disease Models, Animal; Drug Therapy, Combination; Female; Muscarinic Antagonists; Rats; Rats, Inbred SHR; Solifenacin Succinate; Stress, Physiological; Thiazoles; Urinary Bladder; Urinary Bladder, Overactive; Urological Agents | 2017 |
Combinational effects of muscarinic receptor inhibition and β3-adrenoceptor stimulation on neurogenic bladder dysfunction in rats with spinal cord injury.
Topics: Acetanilides; Adrenergic beta-3 Receptor Agonists; Animals; Disease Models, Animal; Drug Therapy, Combination; Female; Mandelic Acids; Muscarinic Antagonists; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Thiazoles; Urinary Bladder; Urinary Bladder, Neurogenic; Urination; Urodynamics; Urological Agents | 2017 |
Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Benzamides; Cell Death; Disease Models, Animal; Disease Progression; Encephalitis; Humans; Male; Motor Neurons; Mutation; Neuroglia; Paralysis; Piperidines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Transgenic; Spinal Cord; Superoxide Dismutase; Thiazoles | 2016 |
The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli.
Topics: Animals; Disease Models, Animal; Endopeptidase Clp; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Female; Gene Deletion; HSP90 Heat-Shock Proteins; Mice, Inbred C57BL; Mutagens; Peptides; Phenols; Polyketides; Protein Interaction Mapping; Rats, Wistar; Siderophores; Thiazoles; Virulence | 2016 |
SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.
Topics: Animals; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Drosophila; Huntington Disease; Neuroprotective Agents; NF-E2-Related Factor 2; Rats; Sirtuin 2; Structure-Activity Relationship; Thiazoles | 2016 |
Dithiazole thione derivative as competitive NorA efflux pump inhibitor to curtail multi drug resistant clinical isolate of MRSA in a zebrafish infection model.
Topics: Animals; Anti-Bacterial Agents; Bacterial Load; Bacterial Proteins; Ciprofloxacin; Disease Models, Animal; Drug Resistance, Multiple, Bacterial; Enzyme Inhibitors; Gene Expression Profiling; Methicillin-Resistant Staphylococcus aureus; Multidrug Resistance-Associated Proteins; Muscles; Real-Time Polymerase Chain Reaction; Skin; Staphylococcal Infections; Thiazoles; Thiones; Treatment Outcome; Zebrafish | 2016 |
A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Coumarins; Disease Models, Animal; Female; Gene Expression; Mice; Mice, Inbred C57BL; Piperazines; Psychotic Disorders; Puerperal Disorders; Steryl-Sulfatase; Sulfonamides; Thiazoles | 2016 |
Neurotransmitter Mechanisms Underlying Sacral Neuromodulation of Bladder Overactivity in Cats.
Topics: Acetic Acid; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Cats; Disease Models, Animal; Excitatory Amino Acid Antagonists; Female; Indicators and Reagents; Male; Naloxone; Narcotic Antagonists; Neurotransmitter Agents; Propranolol; Pyridines; Sacrum; Spinal Cord Stimulation; Spinal Nerve Roots; Thiazoles; Urinary Bladder, Overactive | 2017 |
BP-1T, an antiangiogenic benzophenone-thiazole pharmacophore, counteracts HIF-1 signalling through p53/MDM2-mediated HIF-1α proteasomal degradation.
Topics: Angiogenesis Inhibitors; Animals; Benzophenones; Carcinogenesis; Cell Death; Cell Line; Cell Movement; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Human Umbilical Vein Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitory Concentration 50; Mice; Microvessels; Models, Biological; Neovascularization, Physiologic; Proteasome Endopeptidase Complex; Proteolysis; Proto-Oncogene Proteins c-mdm2; Rats; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53 | 2017 |
Notch pathway plays a novel and critical role in regulating responses of T and antigen-presenting cells in aGVHD.
Topics: Acute Disease; Animals; Antigen-Presenting Cells; Bone Marrow Transplantation; Diamines; Disease Models, Animal; Graft vs Host Disease; Histocompatibility Antigens; Histocompatibility Testing; Mice, Inbred BALB C; Mice, Inbred C57BL; Phenotype; Receptors, Notch; Signal Transduction; T-Lymphocytes; Thiazoles | 2017 |
AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.
Topics: Animals; Colitis; Disease Models, Animal; Forkhead Transcription Factors; Humans; Mice; Receptors, Aryl Hydrocarbon; T-Lymphocytes, Regulatory; Thiazoles; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2016 |
Targeting Cancer Cells with a Bisphosphonate Prodrug.
Topics: Animals; Antineoplastic Agents; Biological Assay; Cell Line, Tumor; Cell Proliferation; Diphosphonates; Disease Models, Animal; Drug Delivery Systems; Humans; Inhibitory Concentration 50; Mice; Molecular Structure; Neoplasms; Prodrugs; Thiazoles | 2016 |
Lithium and valproate act on the GSK-3β signaling pathway to reverse manic-like behavior in an animal model of mania induced by ouabain.
Topics: Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Frontal Lobe; Glycogen Synthase Kinase 3 beta; Hippocampus; Lithium Compounds; Locomotion; Male; Ouabain; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats, Wistar; Signal Transduction; Thiazoles; Urea; Valproic Acid | 2017 |
Thiamet G mediates neuroprotection in experimental stroke by modulating microglia/macrophage polarization and inhibiting NF-κB p65 signaling.
Topics: Acetylglucosamine; Acetylglucosaminidase; Animals; Biomarkers; Disease Models, Animal; Macrophages; Male; Mice, Inbred C57BL; Microglia; N-Acetylglucosaminyltransferases; Neuroprotective Agents; Pyrans; Signal Transduction; Stroke; Thiazoles; Transcription Factor RelA | 2017 |
Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model.
Topics: Animals; Cell Death; Cell Line, Tumor; Cell Survival; Combined Modality Therapy; Disease Models, Animal; Female; Humans; Immunity, Innate; Interferon Regulatory Factor-1; Mice; Molecular Mimicry; Oncolytic Virotherapy; Oncolytic Viruses; Rhabdomyosarcoma; Thiazoles; Tumor Burden; Tumor Necrosis Factor-alpha; Xenograft Model Antitumor Assays | 2017 |
Crosstalk between Notch and Sonic hedgehog signaling in a mouse model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; CD11b Antigen; Diamines; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Hedgehog Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Proteins; Receptors, Notch; Signal Transduction; Spinal Cord; Superoxide Dismutase; Thiazoles; Zinc Finger Protein Gli2 | 2017 |
Sirtuin 1 Activation Reduces Transforming Growth Factor-β1-Induced Fibrogenesis and Affords Organ Protection in a Model of Progressive, Experimental Kidney and Associated Cardiac Disease.
Topics: Acetylation; Anilides; Animals; Biopsy; Blood Pressure; Collagen; Disease Models, Animal; Disease Progression; Feeding Behavior; Fibrosis; Gene Expression Regulation; Genes, Reporter; Glomerulosclerosis, Focal Segmental; Heart Diseases; Heart Function Tests; HEK293 Cells; Humans; Kidney; Kidney Diseases; Kidney Function Tests; Proline; Rats, Inbred F344; Renal Insufficiency, Chronic; RNA, Messenger; Sirtuin 1; Smad3 Protein; Thiazoles; Transforming Growth Factor beta1 | 2017 |
The Specific Protein Kinase R (PKR) Inhibitor C16 Protects Neonatal Hypoxia-Ischemia Brain Damages by Inhibiting Neuroinflammation in a Neonatal Rat Model.
Topics: Animals; Animals, Newborn; Apoptosis; Brain; Cytokines; Disease Models, Animal; eIF-2 Kinase; Hypoxia-Ischemia, Brain; Indoles; Inflammation; Injections, Intraperitoneal; Male; Neurons; Neuroprotective Agents; NF-kappa B; Phosphorylation; Protein Kinase Inhibitors; Rats, Sprague-Dawley; RNA, Messenger; Thiazoles | 2016 |
Antiprotozoal drug nitazoxanide enhances parasitemia, tissue lesions and mortality caused by Trypanosoma cruzi in murine model.
Topics: Animals; Chagas Disease; Disease Models, Animal; Heart; Male; Mice, Inbred BALB C; Muscle, Striated; Myocardium; Nitro Compounds; Parasitemia; Thiazoles; Trypanocidal Agents; Trypanosoma cruzi | 2017 |
Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice.
Topics: Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Male; Mice, Transgenic; Plaque, Amyloid; Species Specificity; Thiazoles | 2017 |
Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Disease Models, Animal; Glucose; Hep G2 Cells; Humans; Indoles; Lipid Metabolism; Liver Neoplasms; Male; Membrane Fluidity; Mice; Mice, Nude; Palmitic Acid; Random Allocation; Sensitivity and Specificity; Thiazoles; Xenograft Model Antitumor Assays | 2017 |
PET imaging of cannabinoid type 2 receptors with [
Topics: Animals; Autoradiography; Brain Ischemia; Carbon Radioisotopes; Disease Models, Animal; Inflammation; Mice; Positron-Emission Tomography; Radiopharmaceuticals; Receptor, Cannabinoid, CB2; Thiazoles | 2017 |
A novel indication of platonin, a therapeutic immunomodulating medicine, on neuroprotection against ischemic stroke in mice.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Brain Ischemia; Cell Death; Collagen; Disease Models, Animal; Free Radicals; Humans; Immunologic Factors; Infarction, Middle Cerebral Artery; Inflammation Mediators; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Models, Biological; Neurons; Neuroprotection; Neuroprotective Agents; Phosphorylation; Platelet Aggregation; RAW 264.7 Cells; Stroke; Thiazoles; Time Factors | 2017 |
Visual evoked potential in RCS rats with Okayama University-type retinal prosthesis (OUReP™) implantation.
Topics: Aniline Compounds; Animals; Disease Models, Animal; Evoked Potentials, Visual; Polyethylene; Prosthesis Implantation; Rats; Retinal Dystrophies; Thiazoles; Visual Prosthesis | 2017 |
Use of the Rat Grimace Scale to Evaluate Neuropathic Pain in a Model of Cervical Radiculopathy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Facial Expression; Male; Meloxicam; Neuralgia; Pain Measurement; Radiculopathy; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Thiazines; Thiazoles; Time Factors; Video Recording | 2017 |
Targeting Th17-IL-17 Pathway in Prevention of Micro-Invasive Prostate Cancer in a Mouse Model.
Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Drug Monitoring; Immunologic Factors; Inflammation; Injections, Intraperitoneal; Interleukin-17; Male; Mice; Molecular Targeted Therapy; Neoplasm Invasiveness; Prostate; Prostatic Neoplasms; Sulfonamides; Th17 Cells; Thiazoles; Treatment Outcome | 2017 |
Activation of Peroxisome Proliferator Activator Receptor β/δ Improves Endothelial Dysfunction and Protects Kidney in Murine Lupus.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Enzyme Activation; Female; Hypertension; Lupus Erythematosus, Systemic; Mice; Mice, Inbred NZB; PPAR delta; Thiazoles | 2017 |
Effects of KP-496, a novel dual antagonist of leukotriene D(4) and thromboxane A (2) receptors on nasal blockage in guinea pig models of allergic rhinitis.
Topics: Airway Resistance; Animals; Area Under Curve; Benzoates; Disease Models, Animal; Guinea Pigs; Humans; Leukotriene Antagonists; Male; Nasal Mucosa; Nasal Obstruction; Ovalbumin; Pollen; Receptors, Leukotriene; Receptors, Thromboxane A2, Prostaglandin H2; Rhinitis, Allergic, Perennial; Sneezing; Thiazoles | 2008 |
Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Microglia; Molecular Structure; Peptides; Plaque, Amyloid; Thiazoles | 2008 |
Anti-inflammatory drugs ameliorate opposite enzymatic changes in ileal 5-hydroxytryptamine metabolism in the delayed phase after cisplatin administration to rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Cisplatin; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dexamethasone; Disease Models, Animal; Enzyme Induction; Enzyme Repression; Hydroxyindoleacetic Acid; Ileitis; Ileum; Intestinal Mucosa; Male; Meloxicam; Membrane Proteins; Monoamine Oxidase; Rats; Rats, Wistar; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Thiazines; Thiazoles; Time Factors; Tryptophan Hydroxylase | 2008 |
Domoic acid induced spinal cord lesions in adult mice: evidence for the possible molecular pathways of excitatory amino acids in spinal cord lesions.
Topics: Animals; Cell Death; Cell Line, Transformed; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Female; In Situ Nick-End Labeling; Kainic Acid; Mice; Mice, Inbred C57BL; Movement Disorders; Proteasome Endopeptidase Complex; Reactive Oxygen Species; Severity of Illness Index; Signal Transduction; Spinal Cord Injuries; Tetrazolium Salts; Thiazoles | 2008 |
The active metabolite of leflunomide A771726 inhibits corneal neovascularization.
Topics: Aniline Compounds; Animals; Cell Nucleus; Cell Proliferation; Corneal Neovascularization; Crotonates; Disease Models, Animal; Humans; Hydrogen-Ion Concentration; Hydroxybutyrates; Immunosuppressive Agents; Isoxazoles; Leflunomide; Nitriles; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Time Factors; Toluidines; Umbilical Veins | 2008 |
Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzothiazoles; Corticosterone; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Mutation; Plaque, Amyloid; Receptors, Corticotropin-Releasing Hormone; Receptors, Glucocorticoid; Stress, Psychological; Thiazoles | 2008 |
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzothiazoles; Cerebral Amyloid Angiopathy; Dimerization; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Plaque, Amyloid; Protein Conformation; Thiazoles | 2008 |
Tetomilast suppressed production of proinflammatory cytokines from human monocytes and ameliorated chronic colitis in IL-10-deficient mice.
Topics: Administration, Oral; Analysis of Variance; Animals; CD4-Positive T-Lymphocytes; Cell Survival; Cells, Cultured; Chronic Disease; Colitis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Interleukin-10; Leukocytes, Mononuclear; Mice; Mice, Inbred C57BL; Probability; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Thiazoles | 2008 |
Molecular polymorphism of Abeta in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Coloring Agents; Congo Red; Diagnostic Imaging; Disease Models, Animal; Humans; Ligands; Molecular Probes; Pathology, Molecular; Plaque, Amyloid; Predictive Value of Tests; Protein Isoforms; Thiazoles | 2010 |
The effectiveness of two COX-2 inhibitors in the prophylaxis against heterotopic new bone formation: an experimental study in rabbits.
Topics: Animals; Bone and Bones; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Indomethacin; Injections, Subcutaneous; Isoxazoles; Male; Meloxicam; Ossification, Heterotopic; Osteogenesis; Rabbits; Radiography; Thiazines; Thiazoles | 2009 |
Calcium entry inhibition during resuscitation from shock attenuates inflammatory lung injury.
Topics: Aminophenols; Animals; Calcium; Calcium Channel Blockers; Capillary Permeability; CD11b Antigen; Disease Models, Animal; Humans; Lung; Male; Neutrophils; Nitrendipine; p38 Mitogen-Activated Protein Kinases; Phosphotransferases (Alcohol Group Acceptor); Pneumonia; Rats; Rats, Sprague-Dawley; Respiratory Burst; Shock, Hemorrhagic; Shock, Traumatic; Thiazoles | 2008 |
Intracranial administration of vaccinia virus complement control protein in Mo/Hu APPswe PS1dE9 transgenic mice at an early age shows enhanced performance at a later age using a cheese board maze test.
Topics: Age Factors; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Association Learning; Behavior, Animal; Benzothiazoles; Complement System Proteins; Conditioning, Psychological; Disease Models, Animal; Genotype; Injections; Maze Learning; Mice; Mice, Transgenic; Reversal Learning; Space Perception; Thiazoles; Viral Proteins | 2008 |
Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats.
Topics: Animals; Antiparkinson Agents; Anxiety Disorders; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Tolerance; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Glutamic Acid; Learning Disabilities; Levodopa; Male; Maze Learning; Memory Disorders; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Synaptic Transmission; Thiazoles | 2008 |
Peroxisome proliferator-activated receptor-delta agonist enhances vasculogenesis by regulating endothelial progenitor cells through genomic and nongenomic activations of the phosphatidylinositol 3-kinase/Akt pathway.
Topics: Animals; Blood Flow Velocity; Bone Marrow; Cells, Cultured; Corneal Neovascularization; Disease Models, Animal; Endothelial Cells; Female; Hematopoietic Stem Cells; Hindlimb; Humans; Ischemia; Male; Mice; Mice, Knockout; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; PPAR delta; Proto-Oncogene Proteins c-akt; Stem Cell Transplantation; Thiazoles; Vascular Diseases | 2008 |
A new method to induce multi-drug resistance to carboplatin in a mouse model of human tongue squamous cell carcinoma.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Carboplatin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Coloring Agents; Disease Models, Animal; DNA Topoisomerases, Type II; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glutathione Transferase; Humans; Immunohistochemistry; Injections, Intradermal; Mice; Mice, Inbred BALB C; Mice, Nude; Multidrug Resistance-Associated Proteins; Neoplasm Transplantation; Reverse Transcriptase Polymerase Chain Reaction; Skin Neoplasms; Tetrazolium Salts; Thiazoles; Tongue Neoplasms; Transplantation, Heterologous; Tumor Cells, Cultured | 2008 |
Administration of ziprasidone for 10 days increases cocaine toxicity in mice.
Topics: Animals; Antipsychotic Agents; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug Synergism; Longevity; Male; Mice; Mice, Inbred Strains; Piperazines; Seizures; Thiazoles; Time Factors; Withholding Treatment | 2008 |
Desferrithiocin analogues and nephrotoxicity.
Topics: Administration, Oral; Animals; Cebus; Dihydropyridines; Disease Models, Animal; Drug Design; Drug Evaluation, Preclinical; Iron; Iron Chelating Agents; Iron Overload; Kidney Diseases; Ligands; Lipids; Male; Molecular Conformation; Rats; Rats, Sprague-Dawley; Stereoisomerism; Thiazoles; Water | 2008 |
Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, Differentiation; Benzothiazoles; Choline O-Acetyltransferase; Disease Models, Animal; Electroretinography; Female; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Transgenic; Microscopy, Confocal; Presenilin-1; Retina; Retinal Diseases; Syntaxin 1; Thiazoles | 2009 |
Neuroprotective effect of naphtha[1,2-d]thiazol-2-amine in an animal model of Parkinson's disease.
Topics: Animals; Antioxidants; Brain; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Glutathione Peroxidase; Haloperidol; Male; Malondialdehyde; Mice; Naphthalenes; Neuroprotective Agents; Oxidative Stress; Parkinson Disease; Superoxide Dismutase; Thiazoles | 2009 |
Voreloxin, formerly SNS-595, has potent activity against a broad panel of cancer cell lines and in vivo tumor models.
Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Immunohistochemistry; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Mice, Nude; Naphthyridines; Neoplasms; Thiazoles; Xenograft Model Antitumor Assays | 2009 |
Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Antimanic Agents; Brain; Citrates; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Exploratory Behavior; Fragile X Mental Retardation Protein; Gene Expression Regulation; Glycogen Synthase Kinase 3; Indoles; Lithium Chloride; Male; Maleimides; Mice; Mice, Knockout; Pyridines; Seizures; Serine; Thiazoles; Urea | 2009 |
Xanthine oxidase inhibition with febuxostat attenuates systolic overload-induced left ventricular hypertrophy and dysfunction in mice.
Topics: Animals; Disease Models, Animal; Febuxostat; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Systole; Thiazoles; Ventricular Dysfunction, Left | 2008 |
Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer's disease model rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies; Benzothiazoles; Cerebral Cortex; Cholesterol; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Hippocampus; Microscopy, Electron, Transmission; Neurofibrillary Tangles; Peptide Fragments; Rats; Rats, Wistar; Thiazoles | 2008 |
A CB(2) receptor agonist, A-836339, modulates wide dynamic range neuronal activity in neuropathic rats: contributions of spinal and peripheral CB(2) receptors.
Topics: Action Potentials; Animals; Camphanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Ganglia, Spinal; Male; Neurons; Peripheral Nervous System Diseases; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord; Thiazoles | 2009 |
The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Benzothiepins; Disease Models, Animal; Male; Models, Molecular; Rats; Rats, Inbred F344; Rats, Wistar; Receptors, Neuropeptide Y; Stress, Psychological; Sulfonamides; Thiazoles | 2009 |
Synthesis, anticancer, and anti-inflammatory activity evaluation of methanesulfonamide and amidine derivatives of 3,4-diaryl-2-imino-4-thiazolines.
Topics: Amidines; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carrageenan; Cell Line, Tumor; Disease Models, Animal; Drug Screening Assays, Antitumor; Edema; Female; Humans; Male; Pregnancy; Rats; Sulfonamides; Thiazoles | 2009 |
Visualization of brain amyloid and microglial activation in mouse models of Alzheimer's disease.
Topics: Acetamides; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Autoradiography; Brain; Brain Mapping; Disease Models, Animal; Humans; Isotopes; Mice; Mice, Transgenic; Microglia; Mutation; Phenyl Ethers; Positron-Emission Tomography; Protein Binding; tau Proteins; Thiazoles | 2009 |
The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model.
Topics: Animals; Antineoplastic Agents; Aurora Kinases; Cell Proliferation; Cell Survival; Colonic Neoplasms; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Mice; Microtubules; Phenylurea Compounds; Protein Serine-Threonine Kinases; Spindle Apparatus; Thiazoles; Xenograft Model Antitumor Assays | 2009 |
Meloxicam reduces lipopolysaccharide-induced degeneration of dopaminergic neurons in the rat substantia nigra pars compacta.
Topics: Animals; CD11b Antigen; Cyclooxygenase Inhibitors; Disease Models, Animal; Dopamine; Lipopolysaccharides; Male; Meloxicam; Nerve Degeneration; Neurons; Rats; Rats, Wistar; Substantia Nigra; Thiazines; Thiazoles; Tyrosine 3-Monooxygenase | 2009 |
PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models.
Topics: Analysis of Variance; Animals; Annexin A5; Antineoplastic Agents; bcl-2-Associated X Protein; Brain Neoplasms; Bromodeoxyuridine; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Gene Expression Regulation, Neoplastic; Glioma; Humans; Ligands; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Pioglitazone; PPAR gamma; Proto-Oncogene Proteins c-bcl-2; Rats; Retinoid X Receptor gamma; Tetrazolium Salts; Thiazoles; Thiazolidinediones; Transfection; Tretinoin; Tumor Stem Cell Assay | 2009 |
Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Hippocampus; Humans; Memory; Memory Disorders; Mice; Mice, Transgenic; Organ Size; Peptide Fragments; Physical Conditioning, Animal; Protease Nexins; Random Allocation; Receptors, Cell Surface; Recognition, Psychology; Thiazoles; Time Factors | 2009 |
Atorvastatin prevents hippocampal cell death due to quinolinic acid-induced seizures in mice by increasing Akt phosphorylation and glutamate uptake.
Topics: Analysis of Variance; Animals; Atorvastatin; Cell Death; Complex Mixtures; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Heptanoic Acids; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Male; Mice; Oncogene Protein v-akt; Phosphorylation; Pyrroles; Quinolinic Acid; Seizures; Tetrazolium Salts; Thiazoles; Tritium | 2009 |
Effect of non-dopaminergic drug treatment on Levodopa induced dyskinesias in MPTP monkeys: common implication of striatal neuropeptides.
Topics: Animals; Antiparkinson Agents; Benzoxazoles; Cocaine; Corpus Striatum; Disease Models, Animal; Docosahexaenoic Acids; Dopamine; Dopamine Uptake Inhibitors; Dynorphins; Dyskinesia, Drug-Induced; Enkephalins; Female; Iodine Isotopes; Levodopa; Macaca fascicularis; Naltrexone; Neuropeptides; Ovariectomy; Parkinsonian Disorders; Piperidines; Protein Precursors; RNA, Messenger; Sulfonamides; Tachykinins; Thiazoles; Time Factors | 2010 |
Fibrils from designed non-amyloid-related synthetic peptides induce AA-amyloidosis during inflammation in an animal model.
Topics: Amyloid; Amyloidosis; Animals; Benzothiazoles; Coloring Agents; Congo Red; Disease Models, Animal; Female; Humans; Inflammation; Mice; Peptides; Spleen; Thiazoles; Time Factors | 2009 |
Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity.
Topics: Animals; Blood Pressure; Brain Infarction; Cells, Cultured; Dinoprost; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; F2-Isoprostanes; Gas Chromatography-Mass Spectrometry; Glutamic Acid; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Mice; Mice, Inbred C57BL; Neuroglia; Neurons; Neuroprotective Agents; Nitrites; Nitrogen Oxides; Oxidative Stress; Statistics, Nonparametric; Tetrazolium Salts; Thiazoles; Time Factors | 2009 |
Investigation of neuroprotective effects of cyclooxygenase inhibitors in the 6-hydroxydopamine induced rat Parkinson model.
Topics: Amphetamines; Animals; Antiparkinson Agents; Apomorphine; Aspirin; Behavior, Animal; Cyclooxygenase Inhibitors; Disease Models, Animal; Female; Immunohistochemistry; Meloxicam; Neuroprotective Agents; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Wistar; Sympatholytics; Thiazines; Thiazoles | 2009 |
Activity of tyrosine kinase inhibitor Dasatinib in neuroblastoma cells in vitro and in orthotopic mouse model.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cellular Senescence; Dasatinib; Disease Models, Animal; Female; Flow Cytometry; Humans; Immunoenzyme Techniques; In Vitro Techniques; Mice; Mice, Nude; Neoplasm Invasiveness; Neuroblastoma; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Xenograft Model Antitumor Assays | 2009 |
Anti-fibrotic effects of a methylenedioxybenzene compound, CW209292 on dimethylnitrosamine-induced hepatic fibrosis in rats.
Topics: Animals; Benzodioxoles; Body Weight; Cell Proliferation; Dimethylnitrosamine; Disease Models, Animal; Female; Hepatic Stellate Cells; Hydroxyproline; Immunohistochemistry; Liver; Liver Cirrhosis; Male; Molecular Structure; Prothrombin Time; Rats; Rats, Sprague-Dawley; Survival Analysis; Thiazoles | 2009 |
Effect of COX-2 inhibitor meloxicam against traumatic brain injury-induced biochemical, histopathological changes and blood-brain barrier permeability.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain Chemistry; Brain Injuries; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Glutathione; Male; Malondialdehyde; Meloxicam; Neurochemistry; Neurologic Examination; Permeability; Peroxidase; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Thiazines; Thiazoles | 2010 |
[Protective effect of meloxicam against cerebral ischemia/reperfusion injury in normo- and hypertensive].
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Disease Models, Animal; Follow-Up Studies; Hypertension; Injections, Intramuscular; Male; Meloxicam; Middle Cerebral Artery; Rats; Rats, Wistar; Reperfusion Injury; Thiazines; Thiazoles; Treatment Outcome; Ultrasonography, Doppler, Transcranial | 2009 |
A New Transgenic Mouse Model of Gerstmann-Straussler-Scheinker Syndrome Caused by the A117V Mutation of PRNP.
Topics: Animals; Ataxia; Benzothiazoles; Blotting, Western; Brain; Creutzfeldt-Jakob Syndrome; Disease Models, Animal; Gerstmann-Straussler-Scheinker Disease; Humans; Kaplan-Meier Estimate; Mice; Mice, Transgenic; Mutation, Missense; Phenotype; Prion Proteins; Prions; PrPC Proteins; PrPSc Proteins; Thiazoles; Time Factors | 2009 |
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Topics: Animals; Cell Proliferation; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Disease Models, Animal; DNA; Lymphocyte Activation; Lysine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pyrrolidines; Spleen; T-Lymphocytes; Thiazoles | 2009 |
Epirubicin exhibits potent anti-tumor activity in an animal model of malignant glioma when administered via controlled-release polymers.
Topics: Animals; Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Delivery Systems; Epirubicin; Female; Glioma; Humans; Polymers; Rats; Rats, Inbred F344; Tetrazolium Salts; Thiazoles; Time Factors | 2010 |
NO-flurbiprofen reduces amyloid-beta, is neuroprotective in cell culture, and enhances cognition in response to cholinergic blockade.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Avoidance Learning; Cell Line, Tumor; Cognition Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Flurbiprofen; Humans; Immunoprecipitation; Lipopolysaccharides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroblastoma; Neuroprotective Agents; Nitric Oxide Synthase Type II; Peptide Fragments; Prostaglandins; Rats; Rats, Long-Evans; Scopolamine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrazolium Salts; Thiazoles; Transfection | 2009 |
Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotin; Disease Models, Animal; Humans; Immunohistochemistry; Islet Amyloid Polypeptide; Ligands; Male; Mice; Mice, Transgenic; Microscopy, Atomic Force; Molecular Weight; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2010 |
Pharmacological activation of PPARbeta/delta stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice.
Topics: Animals; Cell Line; Disease Models, Animal; Gene Expression; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Muscle Fibers, Skeletal; Muscular Dystrophy, Duchenne; PPAR alpha; PPAR-beta; Sarcolemma; Thiazoles; Utrophin | 2009 |
Ligand activation of peroxisome proliferator-activated receptor-beta/delta and inhibition of cyclooxygenase-2 enhances inhibition of skin tumorigenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Dinoprostone; Disease Models, Animal; Female; Keratinocytes; Keratins; Keratoacanthoma; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Papilloma; PPAR delta; PPAR-beta; RNA, Messenger; Skin Neoplasms; Sulfonamides; Thiazoles; Time Factors | 2010 |
The effects of inhaled KP-496, a novel dual antagonist for cysteinyl leukotriene receptor and thromboxane A(2) receptor, on allergic asthmatic responses in guinea pigs.
Topics: Acetylcholine; Administration, Inhalation; Animals; Anti-Asthmatic Agents; Asthma; Benzoates; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Guinea Pigs; Lung; Male; Ovalbumin; Pneumonia; Receptors, Leukotriene; Receptors, Thromboxane A2, Prostaglandin H2; Thiazoles | 2009 |
A novel transdermal patch incorporating meloxicam: in vitro and in vivo characterization.
Topics: Acrylic Resins; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Chemistry, Pharmaceutical; Diffusion; Disease Models, Animal; Dosage Forms; Drug Compounding; Drug Stability; Edema; Excipients; Freund's Adjuvant; Meloxicam; Mice; Mice, Hairless; Mycobacterium; Osteoarthritis; Permeability; Piroxicam; Povidone; Rats; Rats, Sprague-Dawley; Skin; Skin Absorption; Solubility; Technology, Pharmaceutical; Thiazines; Thiazoles; Tissue Adhesives | 2010 |
PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance.
Topics: Animals; Apoptosis; Autoantibodies; Autoimmune Diseases; Autoimmunity; CD11b Antigen; Cells, Cultured; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Fluoresceins; Gene Expression Regulation; Humans; Hyaluronan Receptors; Immune Tolerance; Macrophages; Mice; Mice, Inbred BALB C; Mice, Knockout; Mitochondrial Proteins; Opsonin Proteins; Phagocytosis; PPAR delta; Promoter Regions, Genetic; RNA, Messenger; Thiazoles; Thymus Gland; Time Factors | 2009 |
A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain; Cell Line; Cells, Cultured; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Mice; Mice, Transgenic; Mutation; Neprilysin; Neurons; Plaque, Amyloid; PPAR delta; Presenilin-1; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Transfection | 2009 |
Up-regulation of the type 3 ryanodine receptor is neuroprotective in the TgCRND8 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutamic Acid; Green Fluorescent Proteins; Humans; Mice; Mice, Transgenic; Mutation; Neurons; Peptide Fragments; Phosphopyruvate Hydratase; Potassium; Presenilin-1; RNA, Messenger; RNA, Small Interfering; Ryanodine Receptor Calcium Release Channel; Tetrazolium Salts; Thiazoles; Up-Regulation | 2010 |
Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Diabetes Mellitus, Type 2; Disease Models, Animal; Fructose-Bisphosphatase; High-Throughput Screening Assays; Humans; Hypoglycemic Agents; Mice; Structure-Activity Relationship; Sulfonylurea Compounds; Thiazoles | 2010 |
Rewiring of hindlimb corticospinal neurons after spinal cord injury.
Topics: Animals; Axotomy; Behavior, Animal; Brain Mapping; Cervical Vertebrae; Disease Models, Animal; Female; Fluorescent Dyes; Forelimb; Hindlimb; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Membrane Potentials; Motor Cortex; Nerve Regeneration; Oxygen; Pyramidal Tracts; Pyrazoles; Rats; Rats, Inbred Lew; Spinal Cord Injuries; Statistics, Nonparametric; Thiazoles | 2010 |
Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy.
Topics: Adenosine Triphosphate; Albuminuria; Animals; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diet; Disease Models, Animal; Disease Progression; Glycation End Products, Advanced; Glycolysis; Ion Channels; Kidney; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; Mitochondrial Proteins; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Superoxides; Thiazoles; Time Factors; Uncoupling Protein 2 | 2010 |
Development of (S)-N6-(2-(4-(isoquinolin-1-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]-thiazole-2,6-diamine and its analogue as a D3 receptor preferring agonist: potent in vivo activity in Parkinson's disease animal models.
Topics: Animals; Antiparkinson Agents; Benzothiazoles; CHO Cells; Cricetinae; Cricetulus; Disease Models, Animal; Free Radical Scavengers; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Isoquinolines; Locomotion; Mice; Parkinson Disease; Radioligand Assay; Rats; Receptors, Dopamine D2; Receptors, Dopamine D3; Reserpine; Structure-Activity Relationship; Thiazoles | 2010 |
Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway.
Topics: Analysis of Variance; Animals; Animals, Newborn; Annexin A5; Brain Infarction; Caspase 3; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Enzyme Inhibitors; Flavanones; Glucose; Hypoxia; Immunoprecipitation; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; L-Lactate Dehydrogenase; Male; Neurologic Examination; Neurons; Neuroprotective Agents; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors | 2010 |
Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Bone Marrow Cells; Cell Proliferation; Cytarabine; Disease Models, Animal; Drug Synergism; Female; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Leukocytes; Mice; Naphthyridines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thiazoles | 2010 |
Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress.
Topics: Animals; Anxiety; Catalase; Chronic Disease; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Glutathione; Isoxazoles; Lactones; Lipid Peroxidation; Male; Meloxicam; Memory; Mice; Motor Activity; Naproxen; Nitrites; Random Allocation; Stress, Psychological; Sulfonamides; Sulfones; Thiazines; Thiazoles | 2010 |
The therapeutic effects of the herbal medicine, Juzen-taiho-to, on amyloid-beta burden in a mouse model of Alzheimer's disease.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Antipsychotic Agents; Benzothiazoles; Bone Marrow Cells; Calcium-Binding Proteins; Cell Culture Techniques; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Drugs, Chinese Herbal; Flow Cytometry; Gene Expression Regulation; Humans; Ki-67 Antigen; Macrophages; Mice; Mice, Transgenic; Microfilament Proteins; Mutation; Thiazoles | 2010 |
Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence.
Topics: Alcoholism; Amino Acids; Analysis of Variance; Animals; Bridged Bicyclo Compounds, Heterocyclic; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Agents; Male; Pyridines; Rats; Rats, Wistar; Reinforcement, Psychology; Self Administration; Stress, Psychological; Thiazoles | 2010 |
Masitinib combined with standard gemcitabine chemotherapy: in vitro and in vivo studies in human pancreatic tumour cell lines and ectopic mouse model.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Disease Models, Animal; Gemcitabine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Male; Mice; Mice, SCID; Pancreatic Neoplasms; Piperidines; Pyridines; Thiazoles | 2010 |
Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Disease Models, Animal; Male; Methylamines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Receptor Agonists; Swimming; Thiazoles; Tryptamines | 2011 |
Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma.
Topics: Animals; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Movement; Dasatinib; Disease Models, Animal; Female; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Thiazoles | 2010 |
Age and meloxicam attenuate the ischemia/reperfusion-induced down-regulation in the NMDA receptor genes.
Topics: Aging; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Ischemia; Disease Models, Animal; Down-Regulation; Male; Meloxicam; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reperfusion Injury; RNA, Messenger; Thiazines; Thiazoles; Treatment Outcome | 2010 |
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
Topics: Administration, Oral; Animals; Antimalarials; Antiprotozoal Agents; Disease Models, Animal; DNA, Protozoan; Drug Stability; Malaria, Falciparum; Mice; Parasitic Sensitivity Tests; Pentamidine; Plasmodium falciparum; Rats; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |
Are tyrosine kinase inhibitors promising for the treatment of systemic sclerosis and other fibrotic diseases?
Topics: Animals; Benzamides; Clinical Trials as Topic; Dasatinib; Disease Models, Animal; Drugs, Investigational; ErbB Receptors; Fibrosis; Graft vs Host Disease; Humans; Imatinib Mesylate; Mixed Connective Tissue Disease; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Pulmonary Fibrosis; Pyrimidines; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Scleroderma, Systemic; Thiazoles | 2010 |
Prevention of ovarian hyperstimulation syndrome in a rat model: efficacy comparison between cabergoline and meloxicam.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Body Weight; Cabergoline; Chorionic Gonadotropin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ergolines; Female; Immunohistochemistry; Injections, Intramuscular; Meloxicam; Organ Size; Ovarian Hyperstimulation Syndrome; Ovary; Ovulation Induction; Pregnancy; Pregnancy, Animal; Probability; Random Allocation; Rats; Rats, Wistar; Thiazines; Thiazoles; Vascular Endothelial Growth Factor A | 2010 |
Peroxisome proliferator-activated receptor delta regulation of miR-15a in ischemia-induced cerebral vascular endothelial injury.
Topics: Animals; Caspase 3; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; DNA Fragmentation; Endothelial Cells; Golgi Apparatus; Hypoxia-Ischemia, Brain; Infarction, Middle Cerebral Artery; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Microvessels; PPAR delta; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Up-Regulation | 2010 |
[Positron emission tomography imaging of cell transplantation in a rat model of Alzheimer's disease].
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Fluorodeoxyglucose F18; Male; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Thiazoles | 2010 |
Effect of inhaled KP-496, a novel dual antagonist of the cysteinyl leukotriene and thromboxane A2 receptors, on a bleomycin-induced pulmonary fibrosis model in mice.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bleomycin; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Inflammation; Leukotriene Antagonists; Male; Mice; Mice, Inbred ICR; Pulmonary Fibrosis; Receptors, Leukotriene; Receptors, Thromboxane A2, Prostaglandin H2; Thiazoles | 2010 |
Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension.
Topics: Animals; Azabicyclo Compounds; Cell Proliferation; Disease Models, Animal; Enzyme Inhibitors; Hemodynamics; Hypertension, Pulmonary; Indoles; Lung; Male; Mice; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; Telemetry; Tetrazolium Salts; Thiazoles; Thymidine; Treatment Outcome | 2010 |
In vivo microfocal computed tomography and micro-magnetic resonance imaging evaluation of antiresorptive and antiinflammatory drugs as preventive treatments of osteoarthritis in the rat.
Topics: Alendronate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Density Conservation Agents; Disease Models, Animal; Drug Therapy, Combination; Epiphyses; Etidronic Acid; Female; Femur; Magnetic Resonance Imaging; Meloxicam; Osteoarthritis, Knee; Osteophyte; Rats; Rats, Sprague-Dawley; Risedronic Acid; Stifle; Thiazines; Thiazoles; Tibia; Tomography, X-Ray Computed; Water | 2010 |
The neuroprotective effect of erythropoietin-transduced human mesenchymal stromal cells in an animal model of ischemic stroke.
Topics: Animals; Antigens, CD; Brain Infarction; Caspase 3; Cell Death; Cell Line; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Flow Cytometry; Gene Expression Regulation; Green Fluorescent Proteins; Humans; Hydrogen Peroxide; Infarction, Middle Cerebral Artery; Lentivirus; Magnetic Resonance Imaging; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Nerve Growth Factors; Nervous System Diseases; Rats; Statistics, Nonparametric; Tetrazolium Salts; Thiazoles; Transduction, Genetic | 2010 |
Increase nitric oxide synthase activity in parotid glands from rats with experimental periodontitis.
Topics: Adenine; Amylases; Animals; Calcium; Cyclic AMP-Dependent Protein Kinase Catalytic Subunits; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Egtazic Acid; Enzyme Inhibitors; Guanidines; Indazoles; Indomethacin; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Organ Size; Ornithine; Parotid Gland; Periodontitis; Piperazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Salivary Proteins and Peptides; Thiazoles | 2010 |
Antifilarial activity in vitro and in vivo of some flavonoids tested against Brugia malayi.
Topics: Animals; Brugia malayi; Coloring Agents; Disease Models, Animal; Elephantiasis, Filarial; Female; Filaricides; Flavanones; Flavonoids; Gerbillinae; Hesperidin; Humans; Male; Murinae; Rutin; Survival Analysis; Tetrazolium Salts; Thiazoles | 2010 |
Evaluation of the anti-inflammatory effects of ellagic acid.
Topics: Anesthetics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Drug Interactions; Ellagic Acid; Inflammation; Isoflurane; Ketorolac; Male; Meloxicam; Perioperative Nursing; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles | 2010 |
Protective role of peroxisome proliferator-activated receptor-β/δ in septic shock.
Topics: Animals; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nitric Oxide Synthase Type II; Phosphorylation; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Shock, Septic; Signal Transduction; Sulfones; Thiazoles; Thiophenes | 2010 |
The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice.
Topics: Abdominal Pain; Aggression; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Azides; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Formaldehyde; Glutamic Acid; Glycogen Synthase Kinase 3; Inflammation; Male; Mice; N-Methylaspartate; Pain Measurement; Sugar Acids; Thiazoles; Urea; Xylose | 2011 |
Age-dependent modifications in the mRNA levels of the rat excitatory amino acid transporters (EAATs) at 48hour reperfusion following global ischemia.
Topics: Aging; Analysis of Variance; Animals; Anti-Inflammatory Agents; Cerebral Cortex; Disease Models, Animal; Encephalitis; Excitatory Amino Acid Transporter 2; Excitatory Amino Acid Transporter 3; Hippocampus; Ischemia; Male; Meloxicam; Phosphopyruvate Hydratase; Rats; Rats, Sprague-Dawley; Reperfusion; RNA, Messenger; Thiazines; Thiazoles | 2010 |
Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis.
Topics: Animals; Bacteremia; Blotting, Western; Cecum; Cell Nucleus; Cells, Cultured; Chromatin Immunoprecipitation; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Hypotension; Immunoenzyme Techniques; Inflammation; Luciferases; Macrophages, Peritoneal; Male; Mice; Mice, Knockout; NF-kappa B; PPAR delta; Rats; Rats, Sprague-Dawley; Sepsis; Signal Transduction; Survival Rate; Thiazoles | 2010 |
Imatinib upregulates compensatory integrin signaling in a mouse model of gastrointestinal stromal tumor and is more effective when combined with dasatinib.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Dasatinib; Disease Models, Animal; Down-Regulation; Gastrointestinal Stromal Tumors; Humans; Imatinib Mesylate; Integrins; Mice; Neoplasm Proteins; Piperazines; Proto-Oncogene Proteins c-kit; Pyrimidines; Reproducibility of Results; Signal Transduction; src-Family Kinases; Thiazoles; Up-Regulation | 2010 |
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA1 Region, Hippocampal; Creatine; Disease Models, Animal; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Thiazoles | 2010 |
Protective effect of montelukast against quinolinic acid/malonic acid induced neurotoxicity: possible behavioral, biochemical, mitochondrial and tumor necrosis factor-α level alterations in rats.
Topics: Acetates; Analysis of Variance; Animals; Behavior, Animal; Body Weight; Brain; Brain Chemistry; Catalase; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Gene Expression Regulation; Lipid Peroxidation; Male; Malonates; Mitochondria; Motor Activity; Neuroprotective Agents; Neurotoxicity Syndromes; Nitrites; Quinolines; Quinolinic Acid; Rats; Rats, Wistar; Sulfides; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2010 |
Two models for weight gain and hyperphagia as side effects of atypical antipsychotics in male rats: validation with olanzapine and ziprasidone.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Disease Models, Animal; Dose-Response Relationship, Drug; Feeding Behavior; Hyperphagia; Male; Olanzapine; Piperazines; Rats; Rats, Sprague-Dawley; Thiazoles; Weight Gain | 2011 |
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Topics: Animals; Apoptosis; Blotting, Western; Carcinoma; Carcinoma, Squamous Cell; Disease Models, Animal; Enzyme Inhibitors; Head and Neck Neoplasms; Humans; Immunohistochemistry; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Squamous Cell; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Radiation Tolerance; Squamous Cell Carcinoma of Head and Neck; Thiazoles; Treatment Outcome | 2011 |
Dual effect of nitric oxide on uterine prostaglandin synthesis in a murine model of preterm labour.
Topics: Animals; Blotting, Western; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; Disease Models, Animal; Enzyme Inhibitors; Female; Guanidines; Inflammation; Lipopolysaccharides; Meloxicam; Mice; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase; Obstetric Labor, Premature; Pregnancy; Radioimmunoassay; Thiazines; Thiazoles; Uterus | 2010 |
Central and peripheral sites of action for CB₂ receptor mediated analgesic activity in chronic inflammatory and neuropathic pain models in rats.
Topics: Analgesia; Analgesics; Animals; Brain; Cannabinoids; Disease Models, Animal; Ganglia, Spinal; Inflammation; Male; Neuralgia; Opioid Peptides; Pain; Pain Perception; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; RNA, Messenger; Spinal Cord; Thiazoles | 2011 |
Platonin mitigates acute lung injury in haemorrhagic shock rats.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Thiazoles; Treatment Outcome | 2011 |
Inhibition of the kynurenine-NAD+ pathway leads to energy failure and exacerbates apoptosis in pneumococcal meningitis.
Topics: Animals; Animals, Newborn; Apoptosis; Chromatography, High Pressure Liquid; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Energy Metabolism; Hippocampus; Kynurenine; Meningitis, Pneumococcal; Myelin Basic Protein; NAD; Rats; Rats, Wistar; Signal Transduction; Sulfonamides; Thiazoles | 2010 |
Honey promotes angiogeneic activity in the rat aortic ring assay.
Topics: Administration, Cutaneous; Animals; Aorta; Biomass; Cytotoxicity Tests, Immunologic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Honey; Humans; Neovascularization, Physiologic; Ointments; Osmosis; Rats; Skin Care; Tetrazolium Salts; Thiazoles; Umbilical Veins; Wound Healing; Wounds and Injuries | 2010 |
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Female; I-kappa B Kinase; Imidazoles; Mice; Mice, Inbred BALB C; Protein Kinase Inhibitors; Pyridines; Rats; Structure-Activity Relationship; Thiazoles | 2011 |
Increased BOLD activation to predator stressor in subiculum and midbrain of amphetamine-sensitized maternal rats.
Topics: Adrenergic Uptake Inhibitors; Amphetamine; Animals; Behavior, Animal; Brain Mapping; Disease Models, Animal; Fear; Female; Hippocampus; Magnetic Resonance Imaging; Maternal Behavior; Mesencephalon; Odorants; Oxygen; Rats; Rats, Long-Evans; Stress, Psychological; Substantia Nigra; Thiazoles; Up-Regulation; Ventral Tegmental Area | 2011 |
Fear induced neuronal alterations in a genetic model of depression: an fMRI study on awake animals.
Topics: Animals; Brain; Depression; Disease Models, Animal; Fear; Magnetic Resonance Imaging; Male; Neurons; Odorants; Rats; Thiazoles; Wakefulness | 2011 |
Modulation of lipid peroxidation and mitochondrial function improves neuropathology in Huntington's disease mice.
Topics: Adenosine Triphosphate; Age Factors; Aldehydes; Analysis of Variance; Animals; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Embryo, Mammalian; Glutamic Acid; Humans; Huntingtin Protein; Huntington Disease; Imaging, Three-Dimensional; In Situ Nick-End Labeling; Indoles; Lipid Peroxidation; Lipoxygenase Inhibitors; Male; Masoprocol; Membrane Potential, Mitochondrial; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Mitochondria; Neostriatum; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Oxidative Stress; Synapses; Tetrazolium Salts; Thiazoles; Trinucleotide Repeat Expansion | 2011 |
Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer's.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Peptide Fragments; Plaque, Amyloid; Proteins; Regression Analysis; Thiazoles | 2011 |
Evidence for antimanic efficacy of glycogen synthase kinase-3 (GSK3) inhibitors in a strain-specific model of acute mania.
Topics: Amphetamine; Animals; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Blood-Brain Barrier; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glycogen Synthase Kinase 3; Humans; Indoles; Male; Maleimides; Mice; Mice, Mutant Strains; Molecular Targeted Therapy; Motor Activity; Reproducibility of Results; Thiadiazoles; Thiazoles; Urea | 2011 |
Effect of structurally constrained oxime-ether linker on PPAR subtype selectivity: Discovery of a novel and potent series of PPAR-pan agonists.
Topics: Animals; Cricetinae; Disease Models, Animal; Ether; Hep G2 Cells; Humans; Hypoglycemic Agents; Male; Mice; Mice, Obese; Oximes; Peroxisome Proliferator-Activated Receptors; PPAR alpha; PPAR delta; PPAR gamma; Structure-Activity Relationship; Thiazoles | 2011 |
Antiviral activity of recombinant cyanovirin-N against HSV-1.
Topics: Animals; Antiviral Agents; Bacterial Proteins; Biological Products; Carrier Proteins; Cell Survival; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Disease Models, Animal; DNA, Viral; Encephalitis, Viral; Female; Herpes Simplex; Herpesvirus 1, Human; Male; Mice; Recombinant Proteins; Survival Analysis; Tetrazolium Salts; Thiazoles; Vero Cells | 2010 |
Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia.
Topics: Animals; Antineoplastic Agents; Cyclin-Dependent Kinase Inhibitor p16; Dasatinib; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Mutation, Missense; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Thiazoles; Transplantation, Isogeneic | 2011 |
The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel
Topics: Animals; Avoidance Learning; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Isoindoles; Learning Disabilities; Lurasidone Hydrochloride; Male; Maze Learning; Memory Disorders; Rats; Rats, Wistar; Reaction Time; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin; Serotonin Agents; Thiazoles; Time Factors | 2011 |
Adipose tissue-targeted 11β-hydroxysteroid dehydrogenase type 1 inhibitor protects against diet-induced obesity.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adipocytes; Adiponectin; Adipose Tissue; Animals; Body Weight; Dietary Fats; Disease Models, Animal; Enzyme Inhibitors; Glucose Intolerance; Injections, Subcutaneous; Male; Mice; Mice, Inbred C57BL; Nicotinamide Phosphoribosyltransferase; Obesity; Piperazines; Sulfonamides; Thiazoles | 2011 |
Biochemical and histological changes in the small intestine of mice with dextran sulfate sodium colitis.
Topics: Animals; Biomarkers; Colitis; Dextran Sulfate; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Ileum; Intestine, Small; Isoleucine; Jejunum; Mice; Mice, Inbred C57BL; Mice, Knockout; Microvilli; Neutrophil Infiltration; Peroxidase; Sucrase; Thiazoles; Time Factors | 2011 |
Immunoregulatory function of bone marrow mesenchymal stem cells in EAE depends on their differentiation state and secretion of PGE2.
Topics: Animals; Bone Marrow Transplantation; Cell Differentiation; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Immunomodulation; Indoleamine-Pyrrole 2,3,-Dioxygenase; Meloxicam; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Thiazines; Thiazoles | 2011 |
In vivo and in vitro activity of the siderophore monosulfactam BAL30072 against Acinetobacter baumannii.
Topics: Acinetobacter baumannii; Acinetobacter Infections; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Interactions; Meropenem; Microbial Sensitivity Tests; Monobactams; Rats; Rodent Diseases; Siderophores; Thiazoles; Thienamycins; Treatment Outcome | 2011 |
Mirtazapine in combination with perospirone synergistically enhances dopamine release in the rat prefrontal cortex via 5-HT1A receptor activation.
Topics: Animals; Depression; Disease Models, Animal; Dopamine; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Isoindoles; Male; Mianserin; Microdialysis; Mirtazapine; Piperazines; Prefrontal Cortex; Pyridines; Rats; Rats, Wistar; Serotonin; Serotonin 5-HT1 Receptor Agonists; Thiazoles | 2011 |
Mixture of cis-3-hexenol and trans-2-hexenal attenuates behavioral and stress responses induced by 2,5-dihydro-2,4,5-trimethylthiazoline and electric footshock stress in rats.
Topics: Adrenocorticotropic Hormone; Aldehydes; Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Disease Models, Animal; Drug Therapy, Combination; Electric Stimulation; Eliminative Behavior, Animal; Hexanols; Male; Olfactory Perception; Rats; Rats, Wistar; Stress, Psychological; Thiazoles | 2011 |
Paw inflammation model in dogs for preclinical pharmacokinetic/pharmacodynamic investigations of nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Female; Foot; Inflammation; Lameness, Animal; Male; Meloxicam; Pain Measurement; Random Allocation; Reproducibility of Results; Thiazines; Thiazoles | 2011 |
Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer's disease: a long-term follow up study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibiotics, Antineoplastic; Benzothiazoles; Cerebral Amyloid Angiopathy; Disease Models, Animal; Disease Progression; Longitudinal Studies; Male; Peptide Fragments; Rats; Rats, Wistar; Staining and Labeling; Streptozocin; Thiazoles | 2011 |
Mortalin inhibition in experimental Parkinson's disease.
Topics: Action Potentials; Animals; Antiparasitic Agents; Cerebral Cortex; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electron Transport Complex I; Gene Expression Regulation; HSP70 Heat-Shock Proteins; In Vitro Techniques; Male; Neurons; Oxidopamine; Parkinson Disease; Proteomics; Pyridines; Rats; Rats, Wistar; Thiazoles | 2011 |
Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Blood-Brain Barrier; Contrast Media; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Kinetics; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Molecular Targeted Therapy; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Library; Peptides, Cyclic; Plaque, Amyloid; Protein Binding; Sequence Analysis, DNA; Thiazoles | 2011 |
Klebsiella pneumoniae yersiniabactin promotes respiratory tract infection through evasion of lipocalin 2.
Topics: Acute-Phase Proteins; Animals; Blood; Disease Models, Animal; DNA, Bacterial; Feces; Humans; Immunologic Factors; Klebsiella Infections; Klebsiella pneumoniae; Lipocalin-2; Lipocalins; Mass Spectrometry; Mice; Mice, Inbred C57BL; Mice, Knockout; Oncogene Proteins; Phenols; Polymerase Chain Reaction; Proto-Oncogene Proteins; Respiratory System; Respiratory Tract Infections; Thiazoles; Urine; Virulence; Virulence Factors | 2011 |
Synergism between dexketoprofen and meloxicam in an orofacial formalin test was not modified by opioid antagonists.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Facial Pain; Formaldehyde; Ketoprofen; Male; Meloxicam; Mice; Naltrexone; Narcotic Antagonists; Stereoisomerism; Thiazines; Thiazoles | 2011 |
The combined effects of oncolytic reovirus plus Newcastle disease virus and reovirus plus parvovirus on U87 and U373 cells in vitro and in vivo.
Topics: Animals; Brain; Brain Neoplasms; Cell Death; Cell Line, Tumor; Culture Media; Disease Models, Animal; Female; Flow Cytometry; Glioma; Humans; Mice; Mice, SCID; Newcastle disease virus; Oncolytic Viruses; Parvovirus; Tetrazolium Salts; Thiazoles; Viral Load; Xenograft Model Antitumor Assays | 2011 |
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
Topics: Administration, Oral; Alzheimer Disease; Animals; Brain Chemistry; Disease Models, Animal; Female; Humans; Huntington Disease; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Mice; Mice, Transgenic; Sulfonamides; Thiazoles | 2011 |
Treatment of experimental cerebral vasospasm by protein transduction of heme oxygenase 1 (HO-1) conjugated to a residue of 11 arginines.
Topics: Animals; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Heme Oxygenase-1; Male; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Vasospasm, Intracranial | 2011 |
Metabotropic glutamate receptor 5 antagonist protects dopaminergic and noradrenergic neurons from degeneration in MPTP-treated monkeys.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Brain; Brain Mapping; Calbindins; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Fluorine Radioisotopes; Macaca mulatta; MPTP Poisoning; Nerve Degeneration; Neurons; Norepinephrine; Nortropanes; Positron-Emission Tomography; Protein Binding; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; S100 Calcium Binding Protein G; Thiazoles; Tyrosine 3-Monooxygenase | 2011 |
Cryptosporidium-malnutrition interactions: mucosal disruption, cytokines, and TLR signaling in a weaned murine model.
Topics: Animals; Antiparasitic Agents; Cryptosporidiosis; Cryptosporidium parvum; Cytokines; Disease Models, Animal; DNA, Protozoan; Feces; Female; Ileum; Intestinal Mucosa; Malnutrition; Mice; Mice, Inbred C57BL; Nitro Compounds; RNA, Messenger; Thiazoles; Toll-Like Receptors; Weaning; Weight Gain | 2011 |
Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; Astrocytes; Benzothiazoles; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Microglia; Neuroglia; Plaque, Amyloid; Protein Processing, Post-Translational; Receptors, LDL; Thiazoles | 2011 |
Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arterioles; Benzothiazoles; Disease Models, Animal; Ferric Compounds; Humans; Immunoglobulin G; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Nanoparticles; Peptide Fragments; Plaque, Amyloid; Platelet Endothelial Cell Adhesion Molecule-1; Thiazoles | 2011 |
Divergent actions by inhibitors of DP IV and APN family enzymes on CD4+ Teff cell motility and functions.
Topics: Animals; CD13 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Chemokine CXCL12; Chemotaxis; Dipeptidyl Peptidase 4; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Humans; Hydroxamic Acids; Lymphocyte Activation; Lysine; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Pyrroles; Pyrrolidines; Thiazoles; Transgenes | 2011 |
Experimental treatment of Neospora caninum-infected mice with the arylimidamide DB750 and the thiazolide nitazoxanide.
Topics: Administration, Oral; Amidines; Animals; Body Weight; Brain; Cell Line; Chlorocebus aethiops; Coccidiosis; Coccidiostats; Disease Models, Animal; DNA, Protozoan; Female; Fibroblasts; Humans; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Neospora; Nitro Compounds; Polymerase Chain Reaction; Pyridines; Random Allocation; Thiazoles; Vero Cells | 2011 |
Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Benzothiazoles; Biphenyl Compounds; Carrageenan; Catalase; Cell Line; Chromatography, High Pressure Liquid; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Edema; Endotoxins; Ethanol; Formaldehyde; Glutathione Peroxidase; Loranthaceae; Macrophages; Male; Malondialdehyde; Mice; Mice, Inbred ICR; Nitric Oxide; Nitric Oxide Synthase Type II; Pain; Picrates; Plants, Medicinal; Solvents; Sulfonic Acids; Superoxide Dismutase; Thiazoles; Time Factors; Tumor Necrosis Factor-alpha | 2011 |
Antihypertensive effects of peroxisome proliferator-activated receptor-β activation in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Caveolin 1; Disease Models, Animal; Endothelium, Vascular; GTP-Binding Proteins; Heart Rate; Hypertension; Male; Mitogen-Activated Protein Kinase 3; Nitric Oxide Synthase Type III; PPAR-beta; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred SHR; Rats, Wistar; Reactive Oxygen Species; Thiazoles | 2011 |
Evaluation of anti-inflammatory, anti-nociceptive, and anti-ulcerogenic activities of novel synthesized thiazolyl and pyrrolyl steroids.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Carrageenan; Disease Models, Animal; Edema; Inflammation; Pain; Pyrroles; Rats; Rats, Sprague-Dawley; Steroids; Stomach Ulcer; Thiazoles; Ulcer | 2011 |
Comparison of antithrombotic efficacy between edoxaban, a direct factor Xa inhibitor, and fondaparinux, an indirect factor Xa inhibitor under low and high shear rates.
Topics: Animals; Anticoagulants; Antithrombins; Blood Flow Velocity; Carotid Arteries; Disease Models, Animal; Factor Xa Inhibitors; Fondaparinux; Humans; Male; Polysaccharides; Pyridines; Rats; Rats, Wistar; Thiazoles; Thrombosis; Vena Cava, Inferior | 2011 |
The kappa opioid receptor agonist SA14867 has antinociceptive and weak sedative effects in models of acute and chronic pain.
Topics: Acetamides; Acute Pain; Analgesics; Animals; Arthritis; Chronic Pain; Disease Models, Animal; Hyperalgesia; Hypnotics and Sedatives; Ligation; Male; Mice; Morphine; Neuralgia; Pain Threshold; Pyrrolidines; Receptors, Opioid, kappa; Sciatic Nerve; Stress, Physiological; Tartrates; Temperature; Thiazoles | 2011 |
Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Anti-Bacterial Agents; Benzothiazoles; Caspase 3; Cell Line, Tumor; Disease Models, Animal; Doxycycline; Drosophila melanogaster; Fluorescent Dyes; Humans; Longevity; Thiazoles | 2011 |
Lack of angiogenesis in experimental brain metastases.
Topics: Angiopoietin-1; Animals; Brain Neoplasms; Breast Neoplasms; Bromodeoxyuridine; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; DNA-Binding Proteins; Electron Microscope Tomography; Female; Glial Fibrillary Acidic Protein; Humans; Keratins; Lamins; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Quinolines; Receptor, Platelet-Derived Growth Factor beta; Thiazoles; Vascular Endothelial Growth Factor A | 2011 |
Involvement of metabotropic glutamate receptor 5 in pudendal inhibition of nociceptive bladder activity in cats.
Topics: Acetic Acid; Animals; Cats; Disease Models, Animal; Female; Pain; Pudendal Nerve; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles; Urinary Bladder; Urinary Bladder Diseases; Urination | 2011 |
Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Behavioral Symptoms; Benzoates; Benzothiazoles; Benzylamines; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Enzyme-Linked Immunosorbent Assay; Fourier Analysis; Habituation, Psychophysiologic; Humans; Mice; Mice, Transgenic; Odorants; Olfactory Pathways; Sensation Disorders; Smell; Thiazoles | 2011 |
A novel small Odorranalectin-bearing cubosomes: preparation, brain delivery and pharmacodynamic study on amyloid-β₂₅₋₃₅-treated rats following intranasal administration.
Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Coumarins; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Glycine; Intracellular Signaling Peptides and Proteins; Lectins; Maze Learning; Peptide Fragments; Rats; Rats, Sprague-Dawley; Streptavidin; Thiazoles; Tissue Distribution | 2012 |
The novel antipsychotic drug lurasidone enhances N-methyl-D-aspartate receptor-mediated synaptic responses.
Topics: Animals; Antipsychotic Agents; Clozapine; Cognition Disorders; Disease Models, Animal; Isoindoles; Lurasidone Hydrochloride; Rats; Receptor, Serotonin, 5-HT2A; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Synaptic Transmission; Thiazoles | 2012 |
p38 MAPK inhibition suppresses the TLR-hypersensitive phenotype in FANCC- and FANCA-deficient mononuclear phagocytes.
Topics: Animals; Cell Line; Dasatinib; Disease Models, Animal; Enzyme Activation; Fanconi Anemia; Fanconi Anemia Complementation Group A Protein; Fanconi Anemia Complementation Group C Protein; Gene Expression Regulation; Gene Knockout Techniques; Humans; Macrophages; Matrix Metalloproteinases; Mice; Mice, Knockout; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Phagocytes; Phenotype; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-jun; Pyrazoles; Pyrimidines; RNA Processing, Post-Transcriptional; Small Molecule Libraries; src-Family Kinases; Thiazoles; Toll-Like Receptors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2012 |
Effect of antisense oligodeoxynucleotide targeted against NF-κB/P65 on cell proliferation and tumorigenesis of gastric cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Humans; Mice; Mice, Nude; Oligodeoxyribonucleotides, Antisense; Staining and Labeling; Stomach Neoplasms; Tetrazolium Salts; Thiazoles; Transcription Factor RelA | 2013 |
Premedication with meloxicam exacerbates intracranial haemorrhage in an immature swine model of non-impact inertial head injury.
Topics: Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Brain; Brain Injuries; Buprenorphine; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Hematoma, Subdural; Injections, Intramuscular; Meloxicam; Premedication; Subarachnoid Hemorrhage; Survival Rate; Swine; Thiazines; Thiazoles | 2012 |
Abnormal visual processing and increased seizure susceptibility result from developmental exposure to the biocide methylisothiazolinone.
Topics: Animals; Disease Models, Animal; Disinfectants; Seizures; Thiazoles; Vision Disorders; Xenopus laevis | 2012 |
Electroacupuncture pretreatment attenuates cerebral ischemic injury through α7 nicotinic acetylcholine receptor-mediated inhibition of high-mobility group box 1 release in rats.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain Injuries; Bridged Bicyclo Compounds, Heterocyclic; Bungarotoxins; Cells, Cultured; Cerebral Cortex; Cerebral Infarction; Disease Models, Animal; Electroacupuncture; Embryo, Mammalian; Gene Expression Regulation; Glucose; HMGB1 Protein; Hypoxia; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Injections, Intraventricular; L-Lactate Dehydrogenase; Male; Neurons; Neuroprotective Agents; Phosphopyruvate Hydratase; Protein Binding; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Statistics, Nonparametric; Tetrazolium Salts; Thiazoles | 2012 |
mGluR5 receptors in the basolateral amygdala and nucleus accumbens regulate cue-induced reinstatement of ethanol-seeking behavior.
Topics: Alcoholism; Amygdala; Animals; Behavior, Animal; Cues; Disease Models, Animal; Ethanol; Extinction, Psychological; Male; Microinjections; Nucleus Accumbens; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Reward; Self Administration; Sucrose; Thiazoles | 2012 |
Role of mGluR5 neurotransmission in reinstated cocaine-seeking.
Topics: Analysis of Variance; Animals; Biotinylation; Blotting, Western; Carrier Proteins; Cocaine; Cocaine-Related Disorders; Cues; Disease Models, Animal; Dopamine Uptake Inhibitors; Drug-Seeking Behavior; Excitatory Amino Acid Agonists; Extinction, Psychological; Glycine; Homer Scaffolding Proteins; Male; Microinjections; Nucleus Accumbens; Phenylacetates; Protein Binding; Protein Transport; Pyridines; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recurrence; Self Administration; Synaptic Transmission; Thiazoles | 2013 |
Protective effect of meloxicam-loaded nanocapsules against amyloid-β peptide-induced damage in mice.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Avoidance Learning; Behavior, Animal; Body Weight; Brain; Catalase; Disease Models, Animal; Exploratory Behavior; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Learning Disabilities; Male; Maze Learning; Meloxicam; Memory Disorders; Mice; Nanocapsules; Peptide Fragments; Superoxide Dismutase; Thiazines; Thiazoles; Time Factors | 2012 |
Repeated microinjections into the medial prefrontal cortex (mPFC) impair extinction of conditioned place preference in mice.
Topics: Analysis of Variance; Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bupivacaine; Central Nervous System Depressants; Conditioning, Operant; Disease Models, Animal; Ethanol; Extinction, Psychological; Learning Disabilities; Male; Meloxicam; Mice; Mice, Inbred DBA; Microinjections; Prefrontal Cortex; Thiazines; Thiazoles; Time Factors | 2012 |
Use of xanthine oxidase inhibitor febuxostat inhibits renal interstitial inflammation and fibrosis in unilateral ureteral obstructive nephropathy.
Topics: Animals; Cell Movement; Cytokines; Disease Models, Animal; Febuxostat; Fibrosis; Kidney; Kidney Diseases; Macrophages; Male; Nephritis, Interstitial; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thiazoles; Transforming Growth Factor beta; Ureteral Obstruction; Xanthine Oxidase | 2012 |
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.
Topics: Acetylglucosamine; Adaptor Proteins, Signal Transducing; Alzheimer Disease; Animals; Carbohydrate Conformation; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Mice; Mice, Transgenic; N-Acetylglucosaminyltransferases; Neurodegenerative Diseases; Neurons; Phosphorylation; Pyrans; tau Proteins; Thiazoles | 2012 |
Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury.
Topics: Animals; Brain Injuries; Calcium-Binding Proteins; Cognition Disorders; Diffusion Tensor Imaging; Disease Models, Animal; Ectodysplasins; Encephalitis; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression Regulation; Glycine; Hippocampus; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Microglia; Movement Disorders; Neurodegenerative Diseases; Neurons; Phenylacetates; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Immunologic; Receptors, Metabotropic Glutamate; Recovery of Function; Statistics, Nonparametric; Thiazoles; Time Factors | 2012 |
17β-estradiol attenuates neural cell apoptosis through inhibition of JNK phosphorylation in SCI rats and excitotoxicity induced by glutamate in vitro.
Topics: Analysis of Variance; Animals; Apoptosis; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Estradiol; Female; Glutamic Acid; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Neurons; Phosphorylation; Pregnancy; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Tetrazolium Salts; Thiazoles; Time Factors | 2012 |
Investigation of the antidyskinetic site of action of metabotropic and ionotropic glutamate receptor antagonists. Intracerebral infusions in 6-hydroxydopamine-lesioned rats with levodopa-induced dyskinesia.
Topics: Animals; Anti-Dyskinesia Agents; Disease Models, Animal; Dyskinesia, Drug-Induced; Excitatory Amino Acid Antagonists; Infusions, Intraventricular; Levodopa; Male; Oxidopamine; Phenols; Piperidines; Putamen; Quinoxalines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, AMPA; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Substantia Nigra; Subthalamic Nucleus; Thiazoles | 2012 |
5-HT1A and 5-HT7 receptors contribute to lurasidone-induced dopamine efflux.
Topics: Animals; Disease Models, Animal; Dopamine; Hippocampus; Isoindoles; Lurasidone Hydrochloride; Male; Nucleus Accumbens; Phenols; Piperazines; Prefrontal Cortex; Pyridines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Serotonin; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Sulfonamides; Thiazoles | 2012 |
Restoring methicillin-resistant Staphylococcus aureus susceptibility to β-lactam antibiotics.
Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; beta-Lactams; Cell Division; Crystallography, X-Ray; Cytoskeletal Proteins; Disease Models, Animal; Drug Resistance, Bacterial; Drug Synergism; Gene Regulatory Networks; Guanosine Diphosphate; Imipenem; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Mutation; Protein Structure, Secondary; Protein Transport; Pyridines; Staphylococcal Infections; Thiazoles; Virulence | 2012 |
Inhibition of cathepsin K reduces cartilage degeneration in the anterior cruciate ligament transection rabbit and murine models of osteoarthritis.
Topics: Alendronate; Animals; Anterior Cruciate Ligament Injuries; Benzamides; Biomarkers; Bone Density Conservation Agents; Cartilage, Articular; Cathepsin K; Collagen Type I; Cysteine Proteinase Inhibitors; Disease Models, Animal; Disease Progression; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoarthritis; Peptide Fragments; Peptides; Rabbits; Thiazoles | 2012 |
Platonin mitigates lung injury in a two-hit model of hemorrhage/resuscitation and endotoxemia in rats.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Endotoxemia; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Resuscitation; Shock, Hemorrhagic; Thiazoles | 2012 |
Essential role of interleukin-6 in post-stroke angiogenesis.
Topics: Analysis of Variance; Angiogenic Proteins; Animals; Bone Marrow Transplantation; Brain; Calcium-Binding Proteins; Cells, Cultured; Cerebral Cortex; Cytokine Receptor gp130; Cytokines; Disease Models, Animal; Embryo, Mammalian; Endothelial Cells; Endothelin-1; Enzyme-Linked Immunosorbent Assay; Gait Disorders, Neurologic; Gene Expression Profiling; Gene Expression Regulation; Glucose; Green Fluorescent Proteins; Hypoxia; Infarction, Middle Cerebral Artery; Interleukin-6; Mice; Mice, Knockout; Microfilament Proteins; Neovascularization, Pathologic; Neuroglia; Neurons; Oligonucleotide Array Sequence Analysis; Perfusion Imaging; Receptor, trkB; Rotarod Performance Test; Signal Transduction; STAT3 Transcription Factor; Tetrazolium Salts; Thiazoles | 2012 |
Role of Src tyrosine kinases in experimental pulmonary hypertension.
Topics: Animals; Apoptosis; Becaplermin; Benzamides; Cell Proliferation; Cells, Cultured; Chemotaxis; Dasatinib; Disease Models, Animal; Dose-Response Relationship, Drug; Hemodynamics; Humans; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Hypoxia; Imatinib Mesylate; Monocrotaline; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phosphorylation; Piperazines; Protein Kinase Inhibitors; Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Pyrimidines; Rats; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; src-Family Kinases; STAT3 Transcription Factor; Thiazoles; Time Factors | 2012 |
Peroxisome proliferator-activated receptor β/δ agonist GW0742 ameliorates cerulein- and taurocholate-induced acute pancreatitis in mice.
Topics: Acute Disease; Amylases; Animals; Cell Adhesion Molecules; Cell Movement; Ceruletide; Disease Models, Animal; Dose-Response Relationship, Drug; Lipase; Male; Mice; Mice, Inbred Strains; Neutrophils; Pancreatitis; PPAR delta; PPAR-beta; Taurocholic Acid; Thiazoles; Time Factors | 2012 |
Identification and characterization of an aβ oligomer precipitating peptide that may be useful to explore gene therapeutic approaches to Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line, Tumor; Centrifugation, Density Gradient; Disease Models, Animal; Genetic Therapy; Humans; Mice; Nephelometry and Turbidimetry; Neurons; Peptides; Sequence Analysis, DNA; Thiazoles | 2012 |
Protection from liver fibrosis by a peroxisome proliferator-activated receptor δ agonist.
Topics: Animals; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Hepatic Stellate Cells; Hepatocytes; Kupffer Cells; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Piperazines; PPAR delta; Sulfonamides; Thiazoles | 2012 |
The preventive effect of garlicin on a porcine model of myocardial infarction reperfusion no-reflow.
Topics: Allyl Compounds; Animals; Benzothiazoles; Cardiotonic Agents; Contrast Media; Disease Models, Animal; Disulfides; Hemodynamics; Male; Myocardial Infarction; Myocardial Reperfusion; No-Reflow Phenomenon; Swine; Swine, Miniature; Thiazoles; Ultrasonography | 2014 |
Amixicile, a novel inhibitor of pyruvate: ferredoxin oxidoreductase, shows efficacy against Clostridium difficile in a mouse infection model.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Benzamides; Clostridioides difficile; Clostridium Infections; Disease Models, Animal; Enzyme Inhibitors; Fidaxomicin; Mice; Microbial Sensitivity Tests; Nitro Compounds; Pyruvate Synthase; Thiazoles; Treatment Outcome; Vancomycin | 2012 |
Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2A.
Topics: Animals; Antineoplastic Agents; B-Lymphocytes; Burkitt Lymphoma; Cell Proliferation; Dasatinib; Disease Models, Animal; Gene Expression; Herpesvirus 4, Human; Mice; Mice, Transgenic; Oncogene Protein p55(v-myc); Pyrimidines; Splenomegaly; Thiazoles; Viral Matrix Proteins | 2012 |
Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity.
Topics: Animals; Animals, Genetically Modified; Axonal Transport; Blood-Brain Barrier; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease Models, Animal; Humans; Hydrazines; Methylene Blue; Mitochondria; Motor Neurons; Mutation; Neurons; Neuroprotective Agents; Phenotype; Phosphorylation; Protein Structure, Tertiary; Sensory Receptor Cells; tau Proteins; Tauopathies; Thiazoles; Vesicle-Associated Membrane Protein 1 | 2012 |
Meloxicam ameliorates motor dysfunction and dopaminergic neurodegeneration by maintaining Akt-signaling in a mouse Parkinson's disease model.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Hypokinesia; Male; Meloxicam; Mesencephalon; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Parkinson Disease; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Thiazines; Thiazoles; Tyrosine 3-Monooxygenase | 2012 |
Ziprasidone attenuates brain injury after focal cerebral ischemia induced by middle cerebral artery occlusion in rats.
Topics: Animals; Antigens, Nuclear; Antipsychotic Agents; Biomarkers; Brain Injuries; Brain Ischemia; Calcium-Binding Proteins; Cerebral Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Microfilament Proteins; Microglia; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Piperazines; Rats; Rats, Sprague-Dawley; Recovery of Function; Severity of Illness Index; Thiazoles | 2012 |
Antimalarial iron chelator, FBS0701, shows asexual and gametocyte Plasmodium falciparum activity and single oral dose cure in a murine malaria model.
Topics: Animals; Antimalarials; Disease Models, Animal; Ethyl Ethers; Iron Chelating Agents; Malaria, Falciparum; Mice; Parasitemia; Plasmodium falciparum; Thiazoles; Treatment Outcome | 2012 |
Imatinib resistance and microcytic erythrocytosis in a KitV558Δ;T669I/+ gatekeeper-mutant mouse model of gastrointestinal stromal tumor.
Topics: Animals; Antineoplastic Agents; Benzamides; Cell Lineage; Dasatinib; Disease Models, Animal; Drug Resistance; Drug Resistance, Neoplasm; Erythrocytes; Exons; Gastrointestinal Stromal Tumors; Imatinib Mesylate; Mice; Mutation; Phenotype; Piperazines; Polycythemia; Proto-Oncogene Proteins c-kit; Pyrimidines; Thiazoles | 2012 |
Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Cell Line; Cell Line, Transformed; Cells, Cultured; Dasatinib; Disease Models, Animal; Enzyme Activation; Longitudinal Studies; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Peptide Fragments; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Thiazoles | 2012 |
The neuroprotective effect of the GSK-3β inhibitor and influence on the extrinsic apoptosis in the ALS transgenic mice.
Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Caspase 8; Cell Count; Disease Models, Animal; fas Receptor; Fas-Associated Death Domain Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Mice, Transgenic; Motor Neurons; Neuroprotective Agents; Phosphorylation; Rotarod Performance Test; Signal Transduction; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Urea | 2012 |
Potentiation of mGlu5 receptors with the novel enhancer, VU0360172, reduces spontaneous absence seizures in WAG/Rij rats.
Topics: Age Factors; Animals; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Hydrolysis; Male; Motor Activity; Niacinamide; Phosphatidylinositol Phosphates; Pyridines; Rats; Rats, Inbred Strains; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Somatosensory Cortex; Thiazoles; Ventral Thalamic Nuclei | 2013 |
Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Dopamine D2 Receptor Antagonists; Female; Haloperidol; Isoindoles; Lurasidone Hydrochloride; Phencyclidine; Piperazines; Piperidines; Pyridines; Pyrimidines; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin 5-HT2 Receptor Agonists; Thiazoles; Urea | 2012 |
Effect of 5-HT5A antagonists in animal models of schizophrenia, anxiety and depression.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Anxiety; Biphenyl Compounds; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Guanidines; Male; Rats; Rats, Wistar; Receptors, Serotonin; Schizophrenia; Serotonin Antagonists; Swimming; Thiazoles; Vocalization, Animal | 2012 |
Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms.
Topics: Amphetamine; Analysis of Variance; Animals; Atorvastatin; Corpus Striatum; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Glutathione; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Male; Malondialdehyde; Mitochondria; Motor Activity; NADH Dehydrogenase; Nitrites; Oxidopamine; Parkinsonian Disorders; Pyrroles; Rats; Rats, Wistar; Simvastatin; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2012 |
Pharmacokinetics of [¹⁸F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Disease Models, Animal; Fluorine Radioisotopes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Thiazoles; Tissue Distribution | 2012 |
MicroRNA155 in the growth and invasion of salivary adenoid cystic carcinoma.
Topics: Animals; Carcinoma, Adenoid Cystic; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Coloring Agents; Disease Models, Animal; Electrophoretic Mobility Shift Assay; ErbB Receptors; Female; G1 Phase; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; Mice; Mice, Inbred BALB C; MicroRNAs; Middle Aged; Neoplasm Invasiveness; NF-kappa B; Parotid Gland; Polymerase Chain Reaction; Salivary Gland Neoplasms; Tetrazolium Salts; Thiazoles; Transcription Factor RelA | 2013 |
Small molecules that protect against β-amyloid-induced cytotoxicity by inhibiting aggregation of β-amyloid.
Topics: Amyloid beta-Peptides; Animals; Benzene Derivatives; Benzothiazoles; Cells, Cultured; Coumaric Acids; Curcumin; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred ICR; Molecular Structure; Molecular Weight; Peptide Fragments; Resveratrol; Stilbenes; Thiazoles | 2012 |
Lab reports and cat scans: can veterinary oncology guide our way to new treatments for human cancers?
Topics: Animals; Antineoplastic Agents; Benzamides; Breast Neoplasms; Cats; Disease Models, Animal; Dogs; Female; Humans; Imatinib Mesylate; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mast-Cell Sarcoma; Neoplasms; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Thiazoles; Transcriptome | 2012 |
Active efflux of Dasatinib from the brain limits efficacy against murine glioblastoma: broad implications for the clinical use of molecularly targeted agents.
Topics: Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Dasatinib; Disease Models, Animal; Endothelium, Vascular; Glioblastoma; Humans; Mice; Mice, Knockout; Molecular Targeted Therapy; Oncogenes; Permeability; Pyrimidines; Signal Transduction; Survival Analysis; Tetrahydroisoquinolines; Thiazoles; Tight Junctions; Tissue Distribution; Treatment Outcome; Xenograft Model Antitumor Assays | 2012 |
Interaction between amyloid-β pathology and cortical functional columnar organization.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Electron Transport Complex IV; Humans; Mice; Mice, Transgenic; Models, Neurological; Mutation; Neural Pathways; Plaque, Amyloid; Presenilin-1; Somatosensory Cortex; Thiazoles | 2012 |
Interactions of CB1 and mGlu5 receptor antagonists in food intake, anxiety and memory models in rats.
Topics: Animals; Anxiety; Disease Models, Animal; Fear; Feeding Behavior; Male; Memory; Piperidines; Pyrazoles; Pyridines; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rimonabant; Thiazoles | 2012 |
Activity of the thiopeptide antibiotic nosiheptide against contemporary strains of methicillin-resistant Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Female; HeLa Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Staphylococcal Infections; Streptomyces; Thiazoles; Time Factors; Vancomycin | 2012 |
c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis.
Topics: Amyotrophic Lateral Sclerosis; Animals; Dasatinib; Disease Models, Animal; Mice; Motor Neurons; Phosphorylation; Proto-Oncogene Proteins c-abl; Pyrimidines; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles | 2012 |
Effect of annexin A2 on hepatopulmonary syndrome rat serum-induced proliferation of pulmonary arterial smooth muscle cells.
Topics: Animals; Annexin A2; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Down-Regulation; Hepatopulmonary Syndrome; Male; MAP Kinase Signaling System; Muscle, Smooth; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; RNA, Small Interfering; Serum; Signal Transduction; Statistics, Nonparametric; Tetrazolium Salts; Thiazoles; Thymidine; Transfection | 2013 |
Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR-δ agonism correlates with impaired NLRP3 inflammasome activation.
Topics: Animals; Carrier Proteins; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dietary Carbohydrates; Disease Models, Animal; Fructokinases; Fructose; Glucose; Hypoglycemic Agents; Inflammasomes; Kidney; Liver; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; PPAR gamma; Seeds; Thiazoles; Zea mays | 2013 |
Hepatoprotective and cytoprotective properties of Hyptis suaveolens against oxidative stress-induced damage by CCl(4) and H(2)O(2).
Topics: Animals; Antioxidants; Carbon Tetrachloride; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Hepatocytes; Histocytochemistry; Humans; Hydrogen Peroxide; Hyptis; Liver; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Staining and Labeling; Tetrazolium Salts; Thiazoles | 2012 |
Behavioural and neuroplastic properties of chronic lurasidone treatment in serotonin transporter knockout rats.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Antigens, Differentiation; Brain-Derived Neurotrophic Factor; Conditioning, Psychological; Disease Models, Animal; Extinction, Psychological; Fear; Gene Expression Regulation; Isoindoles; Lurasidone Hydrochloride; Mood Disorders; Neuronal Plasticity; Prefrontal Cortex; Protein Transport; Rats; Rats, Transgenic; Rats, Wistar; Receptors, GABA; Receptors, Glucocorticoid; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins; Thiazoles; Vesicular Inhibitory Amino Acid Transport Proteins | 2013 |
Assessment of propofol, midazolam and ziprasidone, or the combinations for the prevention of acute cocaine toxicity in a mouse model.
Topics: Animals; Anticonvulsants; Antipsychotic Agents; Cocaine-Related Disorders; Disease Models, Animal; Dopamine Antagonists; Drug Therapy, Combination; GABA Modulators; Male; Mice; Midazolam; Piperazines; Propofol; Seizures; Serotonin Antagonists; Thiazoles | 2013 |
Assessment of Cryptosporidium parvum infection in immunocompetent and immunocompromised mice and its role in triggering intestinal dysplasia.
Topics: Animals; Antiparasitic Agents; Cryptosporidiosis; Cryptosporidium parvum; Cyclin D1; Disease Models, Animal; Female; Immunocompromised Host; Intestinal Mucosa; Intestines; Liver; Mice; Nitro Compounds; Oocysts; Thiazoles | 2013 |
IRC-082451, a novel multitargeting molecule, reduces L-DOPA-induced dyskinesias in MPTP Parkinsonian primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Amantadine; Animals; Antioxidants; Antiparkinson Agents; Behavior, Animal; Chromatography, High Pressure Liquid; Cyclooxygenase Inhibitors; Disease Models, Animal; Dopamine Agents; Dyskinesias; Immunohistochemistry; Levodopa; Macaca fascicularis; Magnetic Resonance Imaging; Male; Neurons; Oxidative Stress; Parkinson Disease; Positron-Emission Tomography; Thiazoles | 2013 |
Fluorine-labeled dasatinib nanoformulations as targeted molecular imaging probes in a PDGFB-driven murine glioblastoma model.
Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Dasatinib; Disease Models, Animal; Fluorine Radioisotopes; Glioblastoma; Kaplan-Meier Estimate; Liposomes; Mice; Micelles; Molecular Targeted Therapy; Nanoconjugates; NIH 3T3 Cells; Positron-Emission Tomography; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-sis; Pyrimidines; Radioactive Tracers; Receptor, Platelet-Derived Growth Factor alpha; Signal Transduction; Thiazoles | 2012 |
Inhibition of PVR with a tyrosine kinase inhibitor, dasatinib, in the swine.
Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Cells, Cultured; Dasatinib; Disease Models, Animal; Electroretinography; Female; Fetus; Pregnancy; Protein Kinase Inhibitors; Pyrimidines; Retinal Detachment; Retinal Pigment Epithelium; Swine; Thiazoles; Vitreoretinopathy, Proliferative; Vitreous Body | 2013 |
Nanoemulsion based gel for transdermal delivery of meloxicam: physico-chemical, mechanistic investigation.
Topics: Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena; Disease Models, Animal; Edema; Female; Gels; Hemolysis; Humans; Male; Meloxicam; Nanotechnology; Particle Size; Rats; Rheology; Skin; Skin Absorption; Surface Properties; Thiazines; Thiazoles | 2013 |
Sequential expressions of MMP-1, TIMP-1, IL-6, and COX-2 genes in induced periapical lesions in rats.
Topics: Animals; Bone Resorption; Cell Count; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Disease Progression; Gene Expression; In Situ Hybridization; Injections, Intraperitoneal; Interleukin-6; Isoenzymes; Macrophages; Mandibular Diseases; Matrix Metalloproteinase 1; Meloxicam; Osteoblasts; Periapical Diseases; Peroxidases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; RNA, Messenger; Thiazines; Thiazoles; Time Factors; Tissue Inhibitor of Metalloproteinase-1 | 2002 |
Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site.
Topics: Amino Acid Substitution; Animals; Benzothiazoles; Binding Sites; Copper; Disease Models, Animal; Female; Histidine; Humans; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Motor Neuron Disease; Motor Neurons; Mutation, Missense; Nerve Tissue Proteins; Neurofibrils; Protein Folding; Spinal Cord; Structure-Activity Relationship; Superoxide Dismutase; Superoxides; Thiazoles | 2002 |
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Clusterin; Disease Models, Animal; Glycoproteins; Mice; Mice, Knockout; Molecular Chaperones; Neurites; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2002 |
Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 3,4-Dihydroxyphenylacetic Acid; Administration, Oral; Animals; Cell Count; Cell Survival; Corpus Striatum; Disease Models, Animal; Dopamine; Homovanillic Acid; Hypoglycemic Agents; Immunohistochemistry; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Neuroglia; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Parkinsonian Disorders; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Substantia Nigra; Thiazoles; Thiazolidinediones; Transcription Factors; Tyrosine 3-Monooxygenase | 2002 |
Thiazolidinediones increase the number of platelets in immune thrombocytopenic purpura mice via inhibition of phagocytic activity of the reticulo-endothelial system.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Autoantibodies; Blood Platelets; COS Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Erythrocytes; Hybridization, Genetic; Hypoglycemic Agents; Macrophages; Male; Mice; Mice, Inbred Strains; Mononuclear Phagocyte System; Phagocytosis; Pioglitazone; Platelet Count; Purpura, Thrombocytopenic, Idiopathic; Receptors, Fc; Thiazoles; Thiazolidinediones | 2002 |
PMT13, a pyrimidone analogue of thiazolidinedione improves insulin resistance-associated disorders in animal models of type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Insulin Resistance; Liver; Mice; Mice, Obese; Pyrimidines; Pyrimidinones; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2002 |
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
Topics: Administration, Topical; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Immunotherapy; Mice; Mice, Transgenic; Microscopy, Fluorescence; Mutation; Phagocytosis; Plaque, Amyloid; Thiazoles | 2002 |
Pretreatment with troglitazone decreases lethality during endotoxemia in mice.
Topics: Administration, Oral; Animals; Chromans; Diet; Disease Models, Animal; Drug Interactions; Endotoxemia; Female; Hypoglycemic Agents; Interleukin-6; Lethal Dose 50; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autoantibodies; Benzothiazoles; Brain; Cerebellum; Disease Models, Animal; Locus Coeruleus; Mice; Mice, Transgenic; Neostriatum; Nerve Growth Factor; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; Signal Transduction; Silver Staining; Thiazoles | 2002 |
Troglitazone ameliorates abnormal activity of protein tyrosine phosphatase in adipose tissues of Otsuka Long-Evans Tokushima Fatty rats.
Topics: Adipose Tissue; Animals; Cell Fractionation; Chromans; Diabetes Mellitus; Disease Models, Animal; Hypoglycemic Agents; Insulin Resistance; Male; Obesity; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
A diet supplemented with thiolic anti-oxidants improves leucocyte function in two strains of prematurely ageing mice.
Topics: Acetylcysteine; Aging, Premature; Animals; Antioxidants; Dietary Supplements; Disease Models, Animal; Female; Leukocytes; Mice; Mice, Inbred BALB C; Species Specificity; Sulfhydryl Compounds; Thiazoles; Thiazolidines | 2002 |
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Disease Models, Animal; Female; Humans; Male; Membrane Proteins; Mice; Mice, Transgenic; Neurotoxins; Plaque, Amyloid; Presenilin-1; Thiazoles | 2002 |
Antiinflammatory and antiarteriosclerotic effects of pioglitazone.
Topics: Animals; Anti-Inflammatory Agents; Arteriosclerosis; Blood Glucose; Blood Pressure; Chemokine CCL2; Coronary Artery Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Inflammation; Insulin; Lipids; Male; Monocytes; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peptidyl-Dipeptidase A; Pioglitazone; Rats; Rats, Inbred WKY; Receptors, CCR2; Receptors, Chemokine; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transforming Growth Factor beta; Transforming Growth Factor beta1; Treatment Outcome | 2002 |
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.
Topics: Amino Acid Substitution; Animals; Apoptosis; Benzothiazoles; Brain; Brain Chemistry; Cell Count; Disease Models, Animal; Homozygote; Humans; Immunohistochemistry; Mice; Mice, Transgenic; Motor Neurons; Neurodegenerative Diseases; Paraparesis; Phenotype; Phosphorylation; Sarcosine; Solubility; Spinal Cord; tau Proteins; Thiazoles | 2002 |
Endothelin-A receptor blockade in porcine pulmonary hypertension.
Topics: Animals; Blood Pressure; Carbon Dioxide; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Humans; Hypertension, Pulmonary; Hypoxia; Infant, Newborn; NG-Nitroarginine Methyl Ester; Oligopeptides; Oxygen; Pulmonary Circulation; Receptor, Endothelin A; Streptococcal Infections; Streptococcus agalactiae; Sus scrofa; Thiazoles | 2002 |
Rosiglitazone treatment restores renal dopamine receptor function in obese Zucker rats.
Topics: Animals; Benzazepines; Binding, Competitive; Blood Glucose; Blood Pressure; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Down-Regulation; Epithelial Cells; Glucose; Hyperinsulinism; Hypoglycemic Agents; Insulin; Kidney; Kidney Tubules, Proximal; Male; Obesity; Rats; Rats, Zucker; Receptors, Dopamine D1; Rosiglitazone; Sodium-Potassium-Exchanging ATPase; Thiazoles; Thiazolidinediones | 2002 |
Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates left ventricular remodeling and failure after experimental myocardial infarction.
Topics: Administration, Oral; Animals; Aspartate Aminotransferases; Blood Glucose; Cytokines; Disease Models, Animal; Disease Progression; Drug Administration Schedule; Echocardiography; Gene Expression; Heart Failure; Heart Ventricles; Hemodynamics; Male; Matrix Metalloproteinase 9; Mice; Myocardial Infarction; Myocardium; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Observer Variation; Organ Size; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Reproducibility of Results; RNA, Messenger; Survival Rate; Thiazoles; Thiazolidinediones; Transcription Factors; Ventricular Dysfunction, Left; Ventricular Remodeling | 2002 |
Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis.
Topics: Acute Disease; Animals; Antibody Formation; Antioxidants; Chromans; Colitis; Cytokines; Disease Models, Animal; Hypoglycemic Agents; Ligands; Mice; Mice, Inbred C57BL; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Th2 Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Binding, Competitive; Blood-Brain Barrier; Brain; Contrast Media; Disease Models, Animal; Gadolinium; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Transgenic; Molecular Probe Techniques; Neurons; Peptide Fragments; Plaque, Amyloid; Predictive Value of Tests; Presenilin-1; Putrescine; Reproducibility of Results; Thiazoles | 2002 |
Rosiglitazone improves insulin resistance, lipid profile and promotes adiposity in a genetic model of metabolic syndrome X.
Topics: Adipose Tissue; Animals; Disease Models, Animal; Glucose; Glucose Tolerance Test; Glycogen; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipids; Male; Metabolic Syndrome; Rats; Rats, Inbred Strains; Rosiglitazone; Thiazoles; Thiazolidinediones | 2002 |
Motor effects of a dopamine stabilizer (GMC1111) in primate models of Parkinson and hemiparkinsonism.
Topics: Animals; Callithrix; Disease Models, Animal; Dopamine; Dyskinesias; Female; Indans; Male; Motor Activity; Oxidopamine; Parkinson Disease; Prosencephalon; Thiazoles | 2003 |
Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation.
Topics: Adipocytes; Animals; Blood Vessels; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Diet; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Male; Matrix Metalloproteinase 12; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Matrix Metalloproteinases, Membrane-Associated; Matrix Metalloproteinases, Secreted; Metalloendopeptidases; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Obese; Mitosis; Obesity; Phenylalanine; Protease Inhibitors; RNA, Messenger; Rosiglitazone; Stromal Cells; Thiazoles; Thiazolidinediones; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-3 | 2003 |
Antitumour 2-(4-aminophenyl)benzothiazoles generate DNA adducts in sensitive tumour cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Benzothiazoles; Disease Models, Animal; DNA Adducts; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Thiazoles; Time Factors; Tumor Cells, Cultured | 2003 |
In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Axons; Benzothiazoles; Cerebral Cortex; Dendrites; Dextrans; Disease Models, Animal; Fluorescent Dyes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Neurites; Neuropil; Plaque, Amyloid; Thiazoles | 2003 |
Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists.
Topics: Administration, Oral; Animals; Biological Availability; COS Cells; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Isoxazoles; Mice; Mice, Mutant Strains; Nuclear Proteins; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Thiazolidinedione inhibition of peritoneal inflammation.
Topics: Animals; Chemokine CCL5; Disease Models, Animal; Endometriosis; Female; Interleukin-1; Leukocyte Count; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Peritonitis; Peroxisome Proliferators; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiazolidinediones; Thioglycolates; Tumor Necrosis Factor-alpha | 2003 |
Differential effects of YM440 a hypoglycemic agent on binding to a peroxisome proliferator-activated receptor gamma and its transactivation.
Topics: 3T3 Cells; Adipose Tissue; Animals; Binding Sites; Biological Transport; Carrier Proteins; Diabetes Mellitus; Disease Models, Animal; Fatty Acid-Binding Proteins; Fish Proteins; Glucokinase; Humans; Hypoglycemic Agents; Ion Channels; Liver; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Mitochondrial Proteins; Oxadiazoles; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Trypsin; Tumor Cells, Cultured; Uncoupling Protein 1 | 2003 |
Prevention of acetic acid-induced colitis by desferrithiocin analogs in a rat model.
Topics: Acetic Acid; Animals; Colitis; Dihydropyridines; Disease Models, Animal; Drug Interactions; Intestinal Mucosa; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Thiazoles | 2003 |
[The renal protective effect of selective cyclooxygenase-2 inhibitor on obstructive nephropathy].
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethacin; Isoenzymes; Male; Meloxicam; Nephritis, Interstitial; Prostaglandin-Endoperoxide Synthases; Protective Agents; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles; Ureteral Obstruction | 2002 |
In vivo pharmacodynamics of a new triazole, ravuconazole, in a murine candidiasis model.
Topics: Animals; Antifungal Agents; Area Under Curve; Candidiasis; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Thiazoles; Triazoles | 2003 |
In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antioxidants; Benzothiazoles; Cerebral Cortex; Cyclic N-Oxides; Disease Models, Animal; Fluorescent Dyes; Free Radical Scavengers; Free Radicals; Infrared Rays; Lasers; Mice; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Nitrogen Oxides; Oxidation-Reduction; Oxidative Stress; Plaque, Amyloid; Reactive Oxygen Species; Thiazoles | 2003 |
Melatonin inhibits growth of diethylstilbestrol-induced prolactin-secreting pituitary tumor in vitro: possible involvement of nuclear RZR/ROR receptors.
Topics: Animals; Diethylstilbestrol; Disease Models, Animal; Male; Melatonin; Nuclear Receptor Subfamily 1, Group F, Member 1; Pituitary Neoplasms; Prolactin; Rats; Rats, Inbred F344; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Thiazoles; Thiosemicarbazones; Trans-Activators | 2003 |
Deleterious effects of acute treatment with a peroxisome proliferator-activated receptor-gamma activator in myocardial ischemia and reperfusion in pigs.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Chromans; Disease Models, Animal; Gene Expression Regulation; Heart; Hypoglycemic Agents; Myocardial Ischemia; Myocardial Reperfusion Injury; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Swine; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Ventricular Dysfunction, Left | 2003 |
Long-lasting anticryptosporidial activity of nitazoxanide in an immunosuppressed rat model.
Topics: Adenosine; Animals; Antiprotozoal Agents; Cryptosporidiosis; Cryptosporidium parvum; Disease Models, Animal; Feces; Immunocompromised Host; Male; Nitro Compounds; Parasite Egg Count; Paromomycin; Rats; Rats, Sprague-Dawley; Thiazoles | 2003 |
A thymulin analogue peptide with powerful inhibitory effects on pain of neurogenic origin.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Capsaicin; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Hot Temperature; Hyperalgesia; Ligation; Male; Meloxicam; Morphine; Pain; Pain Threshold; Peptides; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Reaction Time; Thiazines; Thiazoles; Thymic Factor, Circulating; Time Factors | 2003 |
Combination therapy in treatment of experimental pulmonary aspergillosis: synergistic interaction between an antifungal triazole and an echinocandin.
Topics: Animals; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Echinocandins; Female; Lipopeptides; Lipoproteins; Lung; Lung Diseases, Fungal; Micafungin; Organ Size; Peptides, Cyclic; Rabbits; Thiazoles; Triazoles | 2003 |
Peroxisome proliferator-activated receptors alpha and gamma down-regulate allergic inflammation and eosinophil activation.
Topics: Anilides; Animals; Asthma; Chemotaxis; Disease Models, Animal; DNA-Binding Proteins; Down-Regulation; Eosinophils; GATA3 Transcription Factor; Humans; Inflammation; Lung; Mice; Mice, Inbred BALB C; Mice, Knockout; Rats; Receptors, Cytoplasmic and Nuclear; Respiratory Hypersensitivity; Rosiglitazone; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors | 2003 |
Evaluation of a short duration behaviour-based post-operative pain scoring system in rats.
Topics: Abdominal Pain; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Body Weight; Carbazoles; Disease Models, Animal; Exploratory Behavior; Male; Meloxicam; Motor Activity; Pain Measurement; Pain, Postoperative; Rats; Rats, Inbred F344; Thiazines; Thiazoles; Time Factors | 2003 |
Treatment effects on nigrostriatal projection integrity in partial 6-OHDA lesions: comparison of L-DOPA and pramipexole.
Topics: Amphetamine; Animals; Antiparkinson Agents; Apomorphine; Autoradiography; Behavior, Animal; Benzothiazoles; Binding, Competitive; Corpus Striatum; Disease Models, Animal; Levodopa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Motor Activity; Neuropeptides; Oxidopamine; Parkinsonian Disorders; Pramipexole; Rats; Rats, Sprague-Dawley; Substantia Nigra; Thiazoles; Treatment Outcome; Tritium; Vesicular Biogenic Amine Transport Proteins; Vesicular Monoamine Transport Proteins | 2003 |
Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Inhibitors; Glucose Clamp Technique; Glucose Tolerance Test; Hyperglycemia; Hyperinsulinism; Insulin; Liver; Male; Mice; Mice, Inbred C57BL; Obesity; Piperazines; RNA, Messenger; Sulfonamides; Thiazoles | 2003 |
Rosiglitazone reduces the accelerated neointima formation after arterial injury in a mouse injury model of type 2 diabetes.
Topics: Animals; Blood Glucose; Carotid Arteries; Carotid Artery Injuries; Cells, Cultured; Diabetes Mellitus, Type 2; Diet; Disease Models, Animal; Female; Homozygote; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Islets of Langerhans; Lipids; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Rosiglitazone; Thiazoles; Thiazolidinediones; Tunica Intima | 2003 |
The kynurenine 3-hydroxylase inhibitor Ro 61-8048 improves dystonia in a genetic model of paroxysmal dyskinesia.
Topics: Animals; Chorea; Cricetinae; Disease Models, Animal; Dose-Response Relationship, Drug; Dystonia; Enzyme Inhibitors; Female; Kynurenine 3-Monooxygenase; Male; Mesocricetus; Mixed Function Oxygenases; Sulfonamides; Thiazoles | 2003 |
Nematocidal activity of nitazoxanide in laboratory models.
Topics: Animals; Antinematodal Agents; Antiparasitic Agents; Biological Assay; Caenorhabditis elegans; Disease Models, Animal; Dose-Response Relationship, Drug; Heligmosomatoidea; Mice; Nematoda; Nitro Compounds; Parasitic Diseases, Animal; Thiazoles; Trichinella spiralis; Trichinellosis | 2003 |
Ligands of the peroxisome proliferator-activated receptor-gamma and heart failure.
Topics: Animals; Disease Models, Animal; Heart Failure; Humans; Ligands; Mice; Myocardial Infarction; Pioglitazone; PPAR gamma; Rats; Thiazoles; Thiazolidinediones | 2004 |
Blockade of CRF(1) or V(1b) receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression.
Topics: Animals; Antidepressive Agents; Antidiuretic Hormone Receptor Antagonists; Depression; Disease Models, Animal; Fluoxetine; Indoles; Male; Mice; Mice, Inbred BALB C; Neurons; Pyrrolidines; Receptors, Corticotropin-Releasing Hormone; Stress, Psychological; Thiazoles | 2004 |
Improved therapeutic responses in a xenograft model of human B lymphoma (Namalwa) for liposomal vincristine versus liposomal doxorubicin targeted via anti-CD19 IgG2a or Fab' fragments.
Topics: Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antigens, CD19; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Female; Humans; Immunoglobulin Fragments; Immunoglobulin G; Inhibitory Concentration 50; Liposomes; Lymphoma, B-Cell; Mice; Mice, Inbred BALB C; Mice, SCID; Neoplasm Transplantation; Tetrazolium Salts; Thiazoles; Time Factors; Vincristine | 2004 |
Role of wheat germ agglutinin (WGA) in treatment of experimental cryptosporidiosis.
Topics: Animals; Animals, Suckling; Antiprotozoal Agents; Cryptosporidiosis; Cryptosporidium parvum; Disease Models, Animal; Immunocompromised Host; Mice; Nitro Compounds; Thiazoles; Wheat Germ Agglutinins | 2003 |
AS601245 (1,3-benzothiazol-2-yl (2-[[2-(3-pyridinyl) ethyl] amino]-4 pyrimidinyl) acetonitrile): a c-Jun NH2-terminal protein kinase inhibitor with neuroprotective properties.
Topics: Acetonitriles; Animals; Benzothiazoles; Brain Ischemia; Disease Models, Animal; Gerbillinae; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Mice; Mice, Inbred C3H; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Phosphorylation; Rats; Rats, Wistar; Thiazoles; Tumor Necrosis Factor-alpha | 2004 |
The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha.
Topics: Animals; Apoptosis; Benzothiazoles; Blotting, Western; Brain; Brain Ischemia; Cell Count; Disability Evaluation; Disease Models, Animal; Dose-Response Relationship, Drug; Immunohistochemistry; Male; Motor Activity; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Toluene; Tumor Suppressor Protein p53 | 2004 |
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Collagen; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Lipopolysaccharides; Mice; Oxazoles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Structure-Activity Relationship; Thiazoles; Tumor Necrosis Factor-alpha | 2004 |
Preventive effect of antioxidants in MPTP-induced mouse model of Parkinson's disease.
Topics: Acetylcysteine; Analysis of Variance; Animals; Antioxidants; Blotting, Western; Brain; Cell Count; Cell Death; Disease Models, Animal; Dopamine; Dopamine Agents; Dose-Response Relationship, Drug; Drug Interactions; Immunohistochemistry; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; MPTP Poisoning; PC12 Cells; Pyrrolidonecarboxylic Acid; Rats; Thiazoles; Thiazolidines; Time Factors; Tyrosine 3-Monooxygenase | 2004 |
Behavioural assessment of the effects of tumour growth in rats and the influence of the analgesics carprofen and meloxicam.
Topics: Analysis of Variance; Animals; Behavior, Animal; Carbazoles; Disease Models, Animal; Male; Meloxicam; Pain; Pain Measurement; Pain, Postoperative; Rats; Rats, Inbred F344; Thiazines; Thiazoles; Urinary Bladder Neoplasms | 2004 |
Inflammation occurs early during the Abeta deposition process in TgCRND8 mice.
Topics: Age Factors; Alzheimer Disease; Amygdala; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; CD11b Antigen; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neocortex; Plaque, Amyloid; Thiazoles | 2004 |
Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Division; Dermatitis, Allergic Contact; Disease Models, Animal; Haplorhini; Humans; Interleukin-2; Keratinocytes; Mice; PPAR gamma; T-Lymphocytes; Thiazoles; Thioctic Acid | 2004 |
5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Disease Models, Animal; Excitatory Amino Acid Antagonists; Kinetics; Models, Molecular; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Structure-Activity Relationship; Thiazoles | 2004 |
The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety.
Topics: Animals; Anxiety; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Pyridines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles | 2004 |
Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Binding, Competitive; Brain; Carbon Radioisotopes; Cerebellum; Disease Models, Animal; Female; Frontal Lobe; Humans; Iodine Radioisotopes; Metabolic Clearance Rate; Mice; Mice, Transgenic; Molecular Structure; Plaque, Amyloid; Positron-Emission Tomography; Radioligand Assay; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2004 |
Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Blood Vessels; Brain; Cholesterol; Copper; Disease Models, Animal; Drug Synergism; Food, Formulated; Immunohistochemistry; Male; Metabolic Clearance Rate; Neurons; Rabbits; Thiazoles; Up-Regulation | 2004 |
Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Heterozygote; Humans; Immunization, Passive; Immunotherapy; Metabolic Clearance Rate; Mice; Mice, Transgenic; Neurites; Neurofibrillary Tangles; Plaque, Amyloid; Thiazoles | 2004 |
Blockade of airway hyperresponsiveness and inflammation in a murine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid.
Topics: Animals; Asthma; Bronchial Hyperreactivity; Bronchitis; Cell Adhesion Molecules; Chemokines; Disease Models, Animal; Eosinophil Cationic Protein; Interleukins; Lung; Mice; NF-kappa B; Ovalbumin; Prodrugs; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species; Thiazoles; Thiazolidines | 2004 |
Alkylating benzamides with melanoma cytotoxicity.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Benzamides; Cell Line, Tumor; Cell Survival; Chlorambucil; Coloring Agents; Disease Models, Animal; Drug Delivery Systems; Drug Design; Ethylamines; HeLa Cells; Humans; Melanoma; Melanoma, Experimental; Mice; Models, Chemical; Neoplasms, Experimental; NIH 3T3 Cells; Procainamide; Tetrazolium Salts; Thiazoles; Time Factors; Tissue Distribution | 2004 |
Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D3 receptor.
Topics: Animals; Antiparkinson Agents; Benzothiazoles; Cell Count; Corpus Striatum; Disease Models, Animal; Dopamine; Dopamine Agonists; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Down-Regulation; Injections, Subcutaneous; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers; Neurons; Neuroprotective Agents; Parkinson Disease; Pramipexole; Receptors, Dopamine D3; Thiazoles | 2004 |
Assemblages of prion fragments: novel model systems for understanding amyloid toxicity.
Topics: Amyloid; Amyloid beta-Peptides; Animals; Astrocytes; Chromatography, Gel; Chromatography, Ion Exchange; Circular Dichroism; Disease Models, Animal; Lipids; Membrane Microdomains; Microscopy, Electron, Transmission; Peptide Fragments; Peptides; Prions; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrenes; Rats; Rats, Wistar; Sodium Dodecyl Sulfate; Spectrometry, Fluorescence; Spectroscopy, Fourier Transform Infrared; Synaptosomes; Temperature; Tetrazolium Salts; Thiazoles | 2004 |
Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Intermediate Filament Proteins; Mice; Mice, Transgenic; Thiazoles | 2004 |
Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors.
Topics: Administration, Oral; Amides; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Models, Molecular; Molecular Structure; Rats; src-Family Kinases; Structure-Activity Relationship; Thiazoles | 2004 |
Isolation and characterization of herpes simplex virus type 1 resistant to aminothiazolylphenyl-based inhibitors of the viral helicase-primase.
Topics: Animals; Antiviral Agents; Disease Models, Animal; DNA Helicases; DNA Primase; Drug Resistance, Viral; Enzyme Inhibitors; Herpesvirus 1, Human; Mice; Mice, Inbred BALB C; Mutagenesis; Thiazoles; Viral Proteins | 2004 |
A novel neurotrophic peptide: APP63-73.
Topics: Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Behavior, Animal; Cell Count; Cell Line, Tumor; Cell Size; Cell Survival; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; L-Lactate Dehydrogenase; Male; Maze Learning; Mice; Nerve Growth Factors; Neuroblastoma; Ovariectomy; Peptide Fragments; Peptides; Random Allocation; Rats; Rats, Wistar; Tetrazolium Salts; Thiazoles; Time Factors | 2004 |
[Characterization of SN-6, a novel exchange inhibitor and its renal protective effect].
Topics: Acute Kidney Injury; Adenosine Triphosphate; Animals; Benzyl Compounds; Calcium; Cells, Cultured; Cricetinae; Depression, Chemical; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Ischemia; Kidney Tubules; LLC-PK1 Cells; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sodium-Calcium Exchanger; Swine; Thiazoles; Thiazolidines | 2004 |
Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time.
Topics: Animals; Apoptosis; Benzothiazoles; Brain; Caspase 3; Caspases; Cell Line; Cricetinae; Disease Models, Animal; Disease Progression; Mesocricetus; Mice; Neurons; PrPSc Proteins; Scrapie; Thiazoles; Toluene; Treatment Outcome; Tumor Suppressor Protein p53 | 2005 |
Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage.
Topics: Animals; Apoptosis; Basilar Artery; Benzothiazoles; Blotting, Western; Brain; Cerebral Angiography; Disease Models, Animal; Dogs; Endothelial Cells; Female; Immunohistochemistry; In Situ Nick-End Labeling; Male; Myocytes, Smooth Muscle; Subarachnoid Hemorrhage; Thiazoles; Toluene; Tumor Suppressor Protein p53; Vasospasm, Intracranial | 2005 |
PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Disease Models, Animal; Feasibility Studies; Female; Metabolic Clearance Rate; Mice; Mice, Transgenic; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tissue Distribution | 2005 |
Chemical conversion of nocathiacin I to nocathiacin II and a lactone analogue of glycothiohexide alpha.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Intercellular Signaling Peptides and Proteins; Mice; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides; Peptides, Cyclic; Thiazoles | 2005 |
Suberoylanilide hydroxamic acid (SAHA) has potent anti-glioma properties in vitro, ex vivo and in vivo.
Topics: Acetylation; Animals; Animals, Newborn; Antineoplastic Agents; Apoptosis; Benzamides; Blotting, Western; Cell Cycle Proteins; Cell Growth Processes; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Dose-Response Relationship, Drug; Flow Cytometry; Glioma; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Mice; Neoplasm Transplantation; Organ Culture Techniques; Peptides, Cyclic; Rats; Rats, Inbred F344; Rats, Wistar; Tetrazolium Salts; Thiazoles; Time Factors; Vorinostat | 2005 |
Ziprasidone pretreatment attenuates the lethal effects of cocaine in a mouse model.
Topics: Acute Disease; Animals; Antipsychotic Agents; Cocaine; Cocaine-Related Disorders; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Overdose; Injections, Intraperitoneal; Mice; Piperazines; Premedication; Random Allocation; Seizures; Single-Blind Method; Survival Analysis; Thiazoles; Treatment Outcome | 2005 |
Clozapine, ziprasidone and aripiprazole but not haloperidol protect against kainic acid-induced lesion of the striatum in mice, in vivo: role of 5-HT1A receptor activation.
Topics: Aminopyridines; Animals; Antipsychotic Agents; Aripiprazole; Clozapine; Corpus Striatum; Disease Models, Animal; Excitatory Amino Acid Agonists; Haloperidol; Kainic Acid; Male; Mice; Mice, Inbred C57BL; Piperazines; Piperidines; Pyridines; Quinolones; Receptor, Serotonin, 5-HT1A; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists; Thiazoles | 2005 |
Antioxidants as novel therapy in a murine model of colitis.
Topics: Animals; Antioxidants; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Flavonoids; Mice; Oxidative Stress; Phenols; Polyphenols; S-Adenosylmethionine; Thiazoles | 2005 |
5-aminolaevulinic acid photodynamic therapy in a transgenic mouse model of skin melanoma.
Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Fibrosis; Flow Cytometry; Humans; Light; Melanoma; Melanoma, Experimental; Mice; Mice, Transgenic; Neoplasm Metastasis; Neoplasms, Experimental; NIH 3T3 Cells; Photochemotherapy; Photosensitizing Agents; Skin Neoplasms; Tetrazolium Salts; Thiazoles; Trypan Blue | 2005 |
Transcriptional therapy with the histone deacetylase inhibitor trichostatin A ameliorates experimental autoimmune encephalomyelitis.
Topics: Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cytokines; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Embryo, Mammalian; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Profiling; Gene Expression Regulation; Glycoproteins; Hydroxamic Acids; Immunohistochemistry; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Neurons; Oligonucleotide Array Sequence Analysis; Peptide Fragments; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index; Spleen; Tetrazolium Salts; Thiazoles; Time Factors | 2005 |
MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats.
Topics: Animals; Antiparkinson Agents; Catalepsy; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electromyography; Haloperidol; Male; Movement; Muscle, Skeletal; Parkinsonian Disorders; Pyridines; Rats; Rats, Wistar; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles; Time Factors | 2005 |
Inhibitory effect of meloxicam, a cyclooxygenase-2 inhibitor, on N-nitrosobis (2-oxopropyl) amine induced biliary carcinogenesis in Syrian hamsters.
Topics: Animals; Apoptosis; Carcinogens; Carcinoma in Situ; Cell Proliferation; Cell Transformation, Neoplastic; Cricetinae; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Epithelium; Female; Gallbladder; Gallbladder Neoplasms; Hyperplasia; Meloxicam; Mesocricetus; Nitrosamines; Proliferating Cell Nuclear Antigen; Thiazines; Thiazoles | 2005 |
Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Female; Kynurenic Acid; Kynurenine 3-Monooxygenase; Levodopa; Macaca fascicularis; Mixed Function Oxygenases; Motor Activity; Parkinsonian Disorders; Quinolinic Acid; Sulfonamides; Thiazoles; Time Factors | 2005 |
Pramipexole has ameliorating effects on levodopa-induced abnormal dopamine turnover in parkinsonian striatum and quenching effects on dopamine-semiquinone generated in vitro.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Antiparkinson Agents; Benzoquinones; Benzothiazoles; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Electron Spin Resonance Spectroscopy; Functional Laterality; Homovanillic Acid; Levodopa; Male; Mice; Mice, Inbred ICR; Oxidopamine; Parkinson Disease; Pramipexole; Thiazoles; Time Factors | 2005 |
Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition.
Topics: Animals; Chemokine CCL4; Disease Models, Animal; Kynurenine; Kynurenine 3-Monooxygenase; Macrophage Inflammatory Proteins; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Mixed Function Oxygenases; ortho-Aminobenzoates; Picolinic Acids; Plasmodium berghei; Sulfonamides; Thiazoles | 2005 |
Protective effects of a peroxisome proliferator-activated receptor-beta/delta agonist in experimental autoimmune encephalomyelitis.
Topics: Animals; Brain; Concanavalin A; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation, Enzymologic; Glycoproteins; Immunohistochemistry; Interferon-gamma; Lymphocyte Activation; Lymphocytes; Mice; Mice, Inbred C57BL; Myelin Basic Protein; Myelin-Oligodendrocyte Glycoprotein; Neuroglia; Peptide Fragments; PPAR delta; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Severity of Illness Index; Thiazoles; Time Factors | 2005 |
Evaluation of the benzothiazole aggregation inhibitors riluzole and PGL-135 as therapeutics for Huntington's disease.
Topics: Animals; Benzothiazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Genotype; Huntington Disease; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Transgenic; Neuroprotective Agents; Organ Culture Techniques; Riluzole; Thiazoles | 2006 |
Inhibition of transient lower esophageal sphincter relaxation and gastroesophageal reflux by metabotropic glutamate receptor ligands.
Topics: Animals; Deglutition; Disease Models, Animal; Esophagus; Female; Ferrets; Gastroesophageal Reflux; Ligands; Muscle Relaxation; Muscle, Smooth; Pressure; Pyridines; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Thiazoles | 2005 |
Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Antipsychotic Agents; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Haloperidol; Indoles; Isoindoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Obsessive-Compulsive Disorder; Piperazines; Receptor, Serotonin, 5-HT1A; Risperidone; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 2005 |
Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia.
Topics: Animals; Brain Infarction; Brain Ischemia; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Extracellular Space; Glutamic Acid; Guanidines; Mice; N-Methylaspartate; Neurons; Reperfusion; Sodium-Hydrogen Exchangers; Tetrazolium Salts; Thiazoles | 2005 |
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
Topics: 3-Hydroxybutyric Acid; alpha-Synuclein; Amino Acid Sequence; Animals; Animals, Genetically Modified; Antioxidants; Apoptosis; Benzoates; Benzothiazoles; Bile Acids and Salts; Caenorhabditis elegans; Cholagogues and Choleretics; Copper; Disease Models, Animal; Electron Transport Complex I; Gene Deletion; Gene Expression Regulation; Gene Library; Genetic Techniques; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Ions; Iron; Mitochondria; Molecular Sequence Data; Mutagenesis; Mutation; Neurons; Oncogene Proteins; Oxygen Consumption; Paraquat; Parkinson Disease; Polyenes; Probucol; Protein Deglycase DJ-1; Pyrazoles; Pyridazines; RNA, Small Interfering; Rotenone; Sequence Homology, Amino Acid; Sodium Azide; Taurochenodeoxycholic Acid; Thiazoles; Time Factors; Transgenes; Ubiquitin-Protein Ligases | 2005 |
In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice.
Topics: Age Factors; Alzheimer Disease; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Plaque, Amyloid; Staining and Labeling; Thiazoles | 2005 |
1-methyl-4-phenylpyridinium neurotoxicity is attenuated by adenoviral gene transfer of human Cu/Zn superoxide dismutase.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Count; Cell Line, Tumor; Disease Models, Animal; Female; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Humans; Immunohistochemistry; Motor Activity; Neuroblastoma; Neurotoxicity Syndromes; Parkinson Disease; Rats; Rotarod Performance Test; Substantia Nigra; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Transgenes; Tyrosine 3-Monooxygenase | 2006 |
Rho/ROCK pathway as a target of tumor therapy.
Topics: Amides; Animals; Antineoplastic Agents; Apoptosis; Blotting, Southern; Blotting, Western; Caspases; Cell Survival; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Lovastatin; Male; Mevalonic Acid; Mice; Neoplasms; Neoplasms, Experimental; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured | 2006 |
Lipid-lowering properties of 6-benzoyl-2(3H)-benzothiazolone and structurally related compounds.
Topics: Animals; Benzothiazoles; Body Weight; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Mice; Molecular Structure; Organ Size; Thiazoles | 2005 |
Pramipexole protects against MPTP toxicity in non-human primates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Analysis of Variance; Animals; Antioxidants; Benzothiazoles; Callithrix; Cell Count; Corpus Striatum; Disease Models, Animal; Drug Administration Schedule; Female; Immunohistochemistry; Male; MPTP Poisoning; Pramipexole; Thiazoles; Time Factors; Tyrosine 3-Monooxygenase | 2006 |
Glutathione-enhancing agents protect against steatohepatitis in a dietary model.
Topics: Animals; Choline; Cytokines; Disease Models, Animal; Fatty Liver; Food, Formulated; Inflammation; Lipotropic Agents; Male; Methionine; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine; Thiazoles; Transaminases | 2006 |
Effect of dendritic cell vaccine against a tongue squamous cell cancer cell line (Tca8113) in vivo and in vitro.
Topics: Animals; Cancer Vaccines; Carcinoma, Squamous Cell; Cell Line, Tumor; Coloring Agents; Dendritic Cells; Disease Models, Animal; Disease Progression; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Immunophenotyping; Interleukin-4; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; T-Lymphocytes; Tetrazolium Salts; Thiazoles; Tongue Neoplasms; Tumor Necrosis Factor-alpha | 2006 |
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
Topics: ADAM Proteins; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Antibodies, Monoclonal; Basigin; Behavior, Animal; Blotting, Western; Brain; Cell Count; Cytoskeletal Proteins; Dicyclomine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Escape Reaction; Gene Expression; GTP-Binding Proteins; Humans; Immunohistochemistry; Memory Disorders; Mice; Mice, Transgenic; Muscarinic Antagonists; Nuclear Proteins; Piperidines; Protein Kinase C; Reaction Time; Receptor, Muscarinic M1; Spatial Behavior; Spiro Compounds; tau Proteins; Thiazoles; Time Factors | 2006 |
Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model.
Topics: Adenocarcinoma; Animals; Cell Line, Tumor; Dasatinib; Disease Models, Animal; Disease Progression; Humans; Interleukin-8; Mice; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neovascularization, Pathologic; Pancreatic Neoplasms; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-yes; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; RNA, Small Interfering; src-Family Kinases; Thiazoles; Vascular Endothelial Growth Factor A | 2006 |
Protopine inhibits serotonin transporter and noradrenaline transporter and has the antidepressant-like effect in mice models.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzophenanthridines; Berberine Alkaloids; CHO Cells; Cricetinae; Cricetulus; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Head Movements; Hindlimb Suspension; Inhibitory Concentration 50; Male; Mice; Mice, Inbred BALB C; Motor Activity; Norepinephrine Plasma Membrane Transport Proteins; Protein Binding; Serotonin Plasma Membrane Transport Proteins; Tetrazolium Salts; Thiazoles; Transfection | 2006 |
mGlu1 and mGlu5 receptor antagonists lack anticonvulsant efficacy in rodent models of difficult-to-treat partial epilepsy.
Topics: Animals; Anticonvulsants; Behavior, Animal; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Epilepsies, Partial; Excitatory Amino Acid Antagonists; Male; Mice; Microdialysis; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Statistics, Nonparametric; Thiazoles | 2006 |
Effects of group I metabotropic glutamate receptors blockade in experimental models of Parkinson's disease.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Behavior, Animal; Catalepsy; Disease Models, Animal; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesias; Functional Laterality; Haloperidol; Levodopa; Male; Motor Activity; Oxidopamine; Parkinson Disease; Pyridines; Quinolines; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Rotarod Performance Test; Thiazoles; Time Factors | 2006 |
Drug shows promise for treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Humans; Mice; Piperidines; Receptor, Muscarinic M1; Spiro Compounds; Thiazoles | 2006 |
Mortalin-based cytoplasmic sequestration of p53 in a nonmammalian cancer model.
Topics: Animals; Cytosol; Disease Models, Animal; Hemocytes; HSP70 Heat-Shock Proteins; Immunohistochemistry; Immunoprecipitation; Leukemia; Molecular Sequence Data; Mya; Neoplasms; Pyridines; Subcellular Fractions; Thiazoles; Tumor Suppressor Protein p53 | 2006 |
Anti-HCV therapies in chimeric scid-Alb/uPA mice parallel outcomes in human clinical application.
Topics: Analysis of Variance; Animals; Antiviral Agents; Base Sequence; Carbamates; Disease Models, Animal; Hepacivirus; Hepatitis C; Hepatitis C Antibodies; Humans; Interferon alpha-2; Interferon-alpha; Macrocyclic Compounds; Mice; Mice, SCID; Molecular Sequence Data; Oncogene Proteins, Fusion; Probability; Quinolines; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Sensitivity and Specificity; Thiazoles; Treatment Outcome | 2006 |
Memory-related deficits following selective hippocampal expression of Swedish mutation amyloid precursor protein in the rat.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Benzothiazoles; Disease Models, Animal; Fluoresceins; Gene Expression; Genetic Vectors; Hippocampus; Humans; Immunohistochemistry; Male; Maze Learning; Memory Disorders; Mutation; Organic Chemicals; Peptide Fragments; Rats; Rats, Sprague-Dawley; Thiazoles | 2006 |
A model for antipsychotic-induced obesity in the male rat.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Body Composition; Body Weight; Circadian Rhythm; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Feeding Behavior; Haloperidol; Male; Obesity; Olanzapine; Piperazines; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors; Weight Gain | 2006 |
Mechanism underlying the reversal of contractility dysfunction in experimental colitis by cyclooxygenase-2 inhibition.
Topics: Animals; Blotting, Western; Carbachol; Colitis; Colon; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gastrointestinal Motility; Isometric Contraction; Male; Malondialdehyde; Meloxicam; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Peroxidase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazines; Thiazoles; Trinitrobenzenesulfonic Acid | 2006 |
New isothiazole derivatives: synthesis, reactivity, physicochemical properties and pharmacological activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow Cells; Carrageenan; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Edema; Erythrocyte Membrane; Female; Hindlimb; Ibuprofen; Mice; Mice, Inbred CBA; Molecular Structure; Rabbits; Rats; Rats, Wistar; Structure-Activity Relationship; Thiazoles | 2006 |
Ameliorative effect of combined administration of inducible nitric oxide synthase inhibitor with cyclooxygenase-2 inhibitors in neuropathic pain in rats.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Guanidines; Hyperalgesia; Lactones; Male; Meloxicam; Neuralgia; Neurons, Afferent; Nitric Oxide; Nitric Oxide Synthase Type II; Nociceptors; Pain Threshold; Peripheral Nervous System Diseases; Physical Stimulation; Rats; Reaction Time; Sciatic Neuropathy; Sulfones; Thiazines; Thiazoles; Treatment Outcome | 2007 |
Styrylbenzoazole derivatives for imaging of prion plaques and treatment of transmissible spongiform encephalopathies.
Topics: Animals; Animals, Genetically Modified; Blood-Brain Barrier; Cell Line, Tumor; Cricetinae; Disease Models, Animal; Indicators and Reagents; Mice; Neuroblastoma; Prion Diseases; Prions; Styrenes; Thiazoles | 2006 |
Novel robust hepatitis C virus mouse efficacy model.
Topics: Animals; Antiviral Agents; Carbamates; Cell Line, Tumor; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Hepacivirus; Hepatitis C; Humans; Interferon-alpha; Macrocyclic Compounds; Mice; Mice, Inbred BALB C; Mice, Nude; Mice, SCID; Quinolines; Thiazoles; Virus Replication | 2006 |
Dasatinib (BMS-354825) pharmacokinetics and pharmacodynamic biomarkers in animal models predict optimal clinical exposure.
Topics: Adaptor Proteins, Signal Transducing; Administration, Oral; Animals; Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Cell Line, Tumor; Dasatinib; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Fusion Proteins, bcr-abl; Humans; Injections, Intravenous; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, SCID; Nuclear Proteins; Predictive Value of Tests; Pyrimidines; Structure-Activity Relationship; Thiazoles; Time Factors; Transplantation, Heterologous; Xenograft Model Antitumor Assays | 2006 |
Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo.
Topics: Acetates; Animals; Brain; Brain Ischemia; Caspases; Cell Line, Tumor; Cell Survival; Disease Models, Animal; Dopamine; Genes, Reporter; Humans; Ligands; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Parkinson Disease; Phenols; Phenoxyacetates; PPAR delta; Rats; Rats, Wistar; Substrate Specificity; Thiazoles | 2007 |
The helicase primase inhibitor, BAY 57-1293 shows potent therapeutic antiviral activity superior to famciclovir in BALB/c mice infected with herpes simplex virus type 1.
Topics: 2-Aminopurine; Administration, Oral; Animals; Antiviral Agents; Brain Stem; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Ear; Famciclovir; Herpes Simplex; Herpesvirus 1, Human; Injections, Intraperitoneal; Mice; Mice, Inbred BALB C; Mice, Nude; Pyridines; Skin; Sulfonamides; Thiazoles | 2007 |
Interleukin-12 expression enhances vesicular stomatitis virus oncolytic therapy in murine squamous cell carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Coloring Agents; Disease Models, Animal; Gene Expression Regulation, Viral; Gene Transfer Techniques; Genetic Vectors; Injections, Intralesional; Interleukin-12; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Mouth Floor; Mouth Neoplasms; Oncolytic Virotherapy; Oncolytic Viruses; RNA, Viral; Survival Rate; Tetrazolium Salts; Thiazoles; Vesicular stomatitis Indiana virus; Virus Replication | 2007 |
3-(4-Chloro-2-morpholin-4-yl-thiazol-5-yl)-8-(1-ethylpropyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine: a novel brain-penetrant, orally available corticotropin-releasing factor receptor 1 antagonist with efficacy in animal models of alcoholism.
Topics: Administration, Oral; Alcohol Drinking; Alcoholism; Amphibian Proteins; Animals; Anxiety; Behavior, Animal; Brain; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Male; Peptide Hormones; Peptides; Pituitary Gland; Pyridazines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Self Administration; Stress, Physiological; Substance Withdrawal Syndrome; Thiazoles | 2007 |
Superior efficacy of helicase-primase inhibitor BAY 57-1293 for herpes infection and latency in the guinea pig model of human genital herpes disease.
Topics: Animals; Antiviral Agents; Disease Models, Animal; DNA Helicases; DNA Primase; DNA, Viral; Enzyme Inhibitors; Guinea Pigs; Herpes Genitalis; Herpesvirus 2, Human; Humans; Polymerase Chain Reaction; Pyridines; Sulfonamides; Thiazoles | 2007 |
PPARbeta/delta protects against experimental colitis through a ligand-independent mechanism.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Disease Progression; Enterocytes; Female; Gene Expression; Interferon-gamma; Interleukin-6; Ligands; Mice; Mice, Inbred C57BL; Peroxidase; Plasma Substitutes; Polymerase Chain Reaction; PPAR delta; PPAR-beta; RNA, Messenger; Severity of Illness Index; Thiazoles; Tumor Necrosis Factor-alpha | 2007 |
Glucokinase activator PSN-GK1 displays enhanced antihyperglycaemic and insulinotropic actions.
Topics: Animals; Cell Line; Cells, Cultured; Cryopreservation; Disease Models, Animal; Enzyme Activators; Female; Glucokinase; Hepatocytes; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Rats; Rats, Zucker; Sulfones; Thiazoles | 2007 |
Anti-fibrotic effect of meloxicam in a murine lung fibrosis model.
Topics: Animals; Antioxidants; Bleomycin; Collagen; Cyclooxygenase Inhibitors; Disease Models, Animal; Glutathione; Hydroxyproline; Lipid Peroxidation; Male; Malondialdehyde; Meloxicam; Mice; Neovascularization, Pathologic; Peroxidase; Pulmonary Fibrosis; Superoxide Dismutase; Thiazines; Thiazoles | 2007 |
Inhibition of glycogen synthase kinase-3beta protects dopaminergic neurons from MPTP toxicity.
Topics: Analysis of Variance; Animals; Apoptosis; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Freezing Reaction, Cataleptic; Glycogen Synthase Kinase 3; Indoles; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Neurons; Oximes; tau Proteins; Thiazoles; Tyrosine 3-Monooxygenase; Urea | 2007 |
Ziprasidone, diazepam, or the combination for prevention of cocaine toxicity in a mouse model.
Topics: Animals; Cocaine; Cocaine-Related Disorders; Confidence Intervals; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Male; Mice; Mice, Inbred Strains; Piperazines; Random Allocation; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Survival Rate; Thiazoles | 2007 |
Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence.
Topics: Alcohol Drinking; Alcoholism; Amygdala; Animals; Behavior, Animal; Disease Models, Animal; Gene Expression; In Situ Hybridization; Male; Pyridazines; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Stress, Physiological; Thiazoles; Time Factors | 2008 |
Toll-like receptor 4 signal transduction inhibitor, M62812, suppresses endothelial cell and leukocyte activation and prevents lethal septic shock in mice.
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Blood Coagulation; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Endotoxins; Humans; Inflammation Mediators; Injections, Intravenous; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Shock, Septic; Signal Transduction; Thiazoles; Toll-Like Receptor 4; Umbilical Veins; Up-Regulation | 2007 |
Production of angiogenic factors by human glioblastoma cells following activation of the G-protein coupled formylpeptide receptor FPR.
Topics: Angiogenesis Inducing Agents; Animals; Cell Line, Tumor; Cell Proliferation; Corneal Surgery, Laser; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Interleukin-8; Mice; N-Formylmethionine Leucyl-Phenylalanine; Receptors, Formyl Peptide; Tetrazolium Salts; Thiazoles; Time Factors; Transplantation, Heterologous; Vascular Endothelial Growth Factor A | 2008 |
Fenofibrate represses interleukin-17 and interferon-gamma expression and improves colitis in interleukin-10-deficient mice.
Topics: Age Factors; Animals; Cell Count; Chemokine CXCL10; Chemokines, CXC; Colitis; Crohn Disease; Disease Models, Animal; Fenofibrate; Gene Expression; HT29 Cells; Humans; Hypolipidemic Agents; Interferon-gamma; Interleukin-10; Interleukin-17; Mice; Mice, Inbred C3H; Mice, Knockout; PPAR alpha; Spleen; Th1 Cells; Thiazoles | 2007 |
Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys.
Topics: Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Drug Interactions; Dyskinesia, Drug-Induced; Enzyme Inhibitors; Female; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Levodopa; Macaca fascicularis; Motor Activity; Parkinsonian Disorders; Quinolinic Acid; Sulfonamides; Thiazoles; Time Factors | 2008 |
The effects of the short-term administration of low therapeutic doses of anti-COX-2 agents on the healing of fractures. An experimental study in rabbits.
Topics: Analysis of Variance; Animals; Bony Callus; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Fracture Healing; Fractures, Bone; Indomethacin; Lactones; Male; Meloxicam; Prednisolone; Rabbits; Sulfones; Thiazines; Thiazoles | 2007 |
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Antibodies; Disease Models, Animal; Female; Inflammation; Longitudinal Studies; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurofibrillary Tangles; Positron-Emission Tomography; Thiazoles | 2007 |
Inhibitors of dipeptidyl peptidase IV-like activity mediate antifibrotic effects in normal and keloid-derived skin fibroblasts.
Topics: Actins; Animals; Collagen Type I; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Fibroblasts; Fibrosis; Humans; Keloid; Lysine; Mice; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Pyrrolidines; Skin; Thiazoles; Transforming Growth Factor beta1 | 2008 |
Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain.
Topics: Animals; Brain; Caspase 9; Cell Death; Collagen Type XI; Disease Models, Animal; Dose-Response Relationship, Drug; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Kaempferols; Laminin; Male; Matrix Metalloproteinase 9; Neuroprotective Agents; Rats; Rats, Wistar; Reperfusion Injury; Statistics, Nonparametric; Tetrazolium Salts; Thiazoles; Thiobarbituric Acid Reactive Substances; Time Factors | 2007 |
Effects of an ophthalmic formulation of meloxicam on COX-2 expression, PGE2 release, and cytokine expression in a model of acute ocular inflammation.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aqueous Humor; Cornea; Croton Oil; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cytokines; Dinoprostone; Disease Models, Animal; Down-Regulation; Drug Evaluation, Preclinical; Endophthalmitis; Male; Meloxicam; Ophthalmic Solutions; Rabbits; RNA, Messenger; Thiazines; Thiazoles | 2008 |
Farnesyl transferase inhibitors induce neuroprotection by inhibiting Ha-Ras signalling pathway.
Topics: Animals; Brain; Cell Survival; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Excitatory Amino Acid Agonists; Farnesyltranstransferase; Male; Maleates; Mice; N-Methylaspartate; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Proto-Oncogene Proteins p21(ras); Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles | 2007 |
Anti-inflammatory effect of meloxicam on experimental vasospasm in the rat femoral artery.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Femoral Artery; Meloxicam; Random Allocation; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Thiazines; Thiazoles; Vasospasm, Intracranial | 2008 |
Efficacy of antipsychotics to reverse phencyclidine-induced social interaction deficits in female rats--a preliminary investigation.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Behavior, Animal; Clozapine; Disease Models, Animal; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Haloperidol; Matched-Pair Analysis; Phencyclidine; Piperazines; Rats; Rats, Inbred Strains; Schizophrenia; Schizophrenic Psychology; Social Behavior; Social Behavior Disorders; Thiazoles | 2008 |
Effects of KP-496, a novel dual antagonist at the cysteinyl leukotriene receptor 1 and the thromboxane A(2) receptor, on airway obstruction in guinea pigs.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Administration, Inhalation; Administration, Oral; Airway Obstruction; Animals; Anti-Asthmatic Agents; Benzoates; Benzoquinones; Bronchoconstriction; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Guinea Pigs; Heptanoic Acids; Leukotriene Antagonists; Leukotriene D4; Lung; Male; Membrane Proteins; Ovalbumin; Prostaglandin Antagonists; Quinolines; Receptors, Leukotriene; Receptors, Thromboxane A2, Prostaglandin H2; Respiratory Hypersensitivity; Sulfides; Thiazoles; Time Factors | 2008 |
Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Nicotine; Nicotinic Agonists; Photic Stimulation; Pyridines; Rats; Rats, Sprague-Dawley; Reinforcement, Psychology; Self Administration; Thiazoles; Tobacco Use Disorder | 2008 |
Photodynamic therapy using talaporfin sodium for synovial membrane from rheumatoid arthritis patients and collagen-induced arthritis rats.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Coloring Agents; Disease Models, Animal; Fibroblasts; Humans; Injections, Intra-Articular; Laser Therapy; Male; Mice; Mice, SCID; Photosensitizing Agents; Phototherapy; Porphyrins; Radiography; Rats; Rats, Inbred Lew; Synovial Membrane; Tetrazolium Salts; Thiazoles; Transplantation, Heterologous | 2008 |
Dose-dependent effects of meloxicam administration on cyclooxygenase-1 and cyclooxygenase-2 protein expression in intrauterine tissues and fetal tissues of a sheep model of preterm labor.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Meloxicam; Obstetric Labor, Premature; Pregnancy; Sheep; Thiazines; Thiazoles; Uterine Contraction; Uterus | 2007 |
An orthotopic skull base model of malignant meningioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Dacarbazine; Disease Models, Animal; DNA Modification Methylases; DNA Repair Enzymes; Female; Gene Expression Regulation, Neoplastic; Green Fluorescent Proteins; Meningeal Neoplasms; Meningioma; Mice; Mice, Nude; Neoplasm Transplantation; Skull Base Neoplasms; Temozolomide; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Suppressor Proteins | 2008 |
Preliminary evidence of nitazoxanide activity on Toxocara canis in a mouse model.
Topics: Animals; Disease Models, Animal; Mice; Nitro Compounds; Thiazoles; Toxocara canis; Toxocariasis | 2008 |
Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models.
Topics: Animals; Benzimidazoles; Brain Ischemia; Cells, Cultured; Cerebellum; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Microdialysis; Neurons; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Metabotropic Glutamate; Stroke; Thiazoles; Time Factors; Treatment Outcome | 2008 |
Use of antipsychotics to treat cocaine toxicity?
Topics: Animals; Antipsychotic Agents; Cocaine; Cocaine-Related Disorders; Diazepam; Disease Models, Animal; Mice; Piperazines; Thiazoles; Treatment Outcome | 2008 |
In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Cytokines; Disease Models, Animal; Fatty Acids; Heart; Ketones; Male; Metabolic Syndrome; Myocardial Reperfusion Injury; PPAR delta; Proto-Oncogene Proteins c-akt; Rats; Rats, Zucker; RNA, Messenger; Thiazoles; Troponin I | 2008 |
[Significance of cyclooxygenase-2 as a chemotherapeutic target in hepatocellular carcinoma].
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Drug Design; Humans; Liver Neoplasms; Meloxicam; Rats; Thiazines; Thiazoles | 2007 |
Hypoxia-independent activation of HIF-1 by enterobacteriaceae and their siderophores.
Topics: Animals; Caco-2 Cells; Cell Hypoxia; Disease Models, Animal; Endothelial Cells; Enterobacter aerogenes; Enterobacteriaceae; Epithelial Cells; Female; Gene Expression Regulation; HeLa Cells; Humans; Hydroxamic Acids; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Oxygen; Peyer's Patches; Phenols; Procollagen-Proline Dioxygenase; Salmonella enterica; Siderophores; Thiazoles; Time Factors; Transcriptional Activation; Up-Regulation; Yersinia enterocolitica; Yersinia Infections | 2008 |
Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures.
Topics: Amphetamine; Animals; Antioxidants; Apomorphine; Behavior, Animal; Cell Line, Tumor; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Humans; L-Lactate Dehydrogenase; Male; Motor Activity; Neuroblastoma; Oxidopamine; Parkinson Disease; Quercetin; Rats; Rats, Wistar; Substantia Nigra; Tetrazolium Salts; Thiazoles; Tyrosine 3-Monooxygenase | 2008 |
Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model.
Topics: Administration, Inhalation; Aniline Compounds; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokines, CC; Disease Models, Animal; Enzyme Inhibitors; Goblet Cells; Humans; Hyperplasia; Interleukins; Lysophospholipids; Mice; Mice, Inbred C57BL; Ovalbumin; Phosphotransferases (Alcohol Group Acceptor); Respiratory Mucosa; Sphingosine; Thiazoles | 2008 |
Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Apoptosis; Autocrine Communication; Biomarkers, Tumor; Carcinoma, Squamous Cell; Chemokine CCL19; Chemokine CCL21; Cisplatin; Disease Models, Animal; Disease Progression; ErbB Receptors; Female; Formazans; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Immunohistochemistry; Male; Mice; Middle Aged; Paracrine Communication; Receptors, CCR7; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tetrazolium Salts; Thiazoles; Up-Regulation | 2008 |
Immunochemotherapy for cryptosporidiosis in immunosuppressed mouse model.
Topics: Animals; Antiprotozoal Agents; Cryptosporidiosis; Disease Models, Animal; Drug Therapy, Combination; Humans; Immunocompromised Host; Immunotherapy; Interferon-gamma; Life Cycle Stages; Mice; Nitro Compounds; Oocysts; Parasite Egg Count; Paromomycin; Random Allocation; Thiazoles; Time Factors; Treatment Outcome | 2007 |
Biological characters of [18F]O-FEt-PIB in a rat model of Alzheimer's disease using micro-PET imaging.
Topics: Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Diagnostic Imaging; Disease Models, Animal; Fluorodeoxyglucose F18; Hippocampus; Male; Peptide Fragments; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Thalamus; Thiazoles; Tissue Distribution | 2008 |
Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia.
Topics: Animals; Disease Models, Animal; Febuxostat; Hyperuricemia; Kidney; Kidney Failure, Chronic; Male; Microcirculation; Nephrectomy; Oxonic Acid; Rats; Rats, Wistar; Recovery of Function; Thiazoles; Treatment Outcome | 2008 |
Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model.
Topics: Animals; Antineoplastic Agents; Cell Movement; Cell Proliferation; Crk-Associated Substrate Protein; Dasatinib; Disease Models, Animal; Drug Delivery Systems; Focal Adhesion Kinase 1; Humans; Lymphatic Metastasis; Male; Mice; Mice, Nude; Prostatic Neoplasms; Pyrimidines; src-Family Kinases; Thiazoles; Tumor Burden; Tumor Cells, Cultured; Tyrosine; Xenograft Model Antitumor Assays | 2008 |
Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions.
Topics: Animals; Behavior, Animal; Blood Glucose; Brain Edema; Calcium-Binding Proteins; Caspase 3; Cerebral Infarction; Cyclooxygenase 2; Disease Models, Animal; Glial Fibrillary Acidic Protein; Glycogen Synthase Kinase 3; Microfilament Proteins; Oxadiazoles; Poly(ADP-ribose) Polymerases; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Sprague-Dawley; Thiazoles; Urea | 2008 |
[Hydroelactic and ecbolic of piprozoline on basal bile-pancreatic secretion in rats].
Topics: Animals; Bile; Bile Acids and Salts; Biliary Fistula; Bilirubin; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Pancreas; Pancreatic Fistula; Rats; Secretin; Thiazoles; Thiazolidines | 1984 |
The Noble rat bladder cancer model. FANFT-induced tumors.
Topics: Animals; Cell Nucleus; Cyclophosphamide; Cytoplasm; Disease Models, Animal; FANFT; Female; Rats; Rats, Inbred Strains; Thiazoles; Time Factors; Urinary Bladder Neoplasms | 1984 |
[Experimental model for determination of an "in vivo" area at risk accounting for the quantity and distribution of collateral flow (author's transl)].
Topics: Animals; Arrhythmias, Cardiac; Autoradiography; Benzothiazoles; Collateral Circulation; Coronary Circulation; Disease Models, Animal; Dogs; Fluorescent Dyes; Microspheres; Myocardial Infarction; Risk; Serum Albumin; Thiazoles | 1982 |
Update on HIV transmission and pathogenesis.
Topics: Animals; Antiviral Agents; CD4-Positive T-Lymphocytes; Disease Models, Animal; Genes, env; HIV; HIV Infections; HIV Protease Inhibitors; HIV-1; HLA-A Antigens; HLA-DR Antigens; HLA-DR Serological Subtypes; Humans; Macaca; Nevirapine; Pyridines; Reverse Transcriptase Inhibitors; Ritonavir; Simian Immunodeficiency Virus; Thiazoles; Time Factors; Valine; Virulence; Virus Latency; Virus Replication | 1995 |
Effect of YM264 on the airway hyperresponsiveness and the late asthmatic response in a guinea pig model of asthma.
Topics: Aerosols; Airway Resistance; Analysis of Variance; Animals; Asthma; Bronchial Hyperreactivity; Disease Models, Animal; Guinea Pigs; Immunization; Male; Ovalbumin; Piperazines; Platelet Activating Factor; Random Allocation; Statistics, Nonparametric; Thiazoles; Thiazolidines; Time Factors; Trachea | 1995 |
Inhibition of allergen-induced lung eosinophilia by type-III and combined type III- and IV-selective phosphodiesterase inhibitors in brown-Norway rats.
Topics: Administration, Inhalation; Aerosols; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bronchoalveolar Lavage Fluid; Cell Count; Disease Models, Animal; Eosinophils; Female; Injections, Intraperitoneal; Neutrophils; Ovalbumin; Phosphodiesterase Inhibitors; Pulmonary Eosinophilia; Pyrrolidinones; Rats; Rats, Inbred BN; Rolipram; Thiazoles | 1995 |
Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling.
Topics: Adipocytes; Adipose Tissue; Affinity Labels; Animals; Azides; Blood Glucose; Cell Membrane; Cholesterol; Diabetes Mellitus, Type 2; Diet; Disaccharides; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Epididymis; Fatty Acids, Nonesterified; Glucose; Glucose Tolerance Test; Glucose Transporter Type 4; Glycosides; Hypoglycemic Agents; Insulin; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Monosaccharide Transport Proteins; Muscle Proteins; Propylamines; Rosiglitazone; Thiazoles; Thiazolidinediones; Triglycerides | 1995 |
Increased endogenous N-nitrosamine and nitrate formation by induction of nitric oxide synthase in rats with acute hepatic injury caused by Propionibacterium acnes and lipopolysaccharide administration.
Topics: Amino Acid Oxidoreductases; Animals; Disease Models, Animal; Enzyme Induction; Lipopolysaccharides; Liver Diseases; Male; Necrosis; Nitrates; Nitric Oxide Synthase; Nitrosamines; Nitroso Compounds; Propionibacterium acnes; Rats; Rats, Sprague-Dawley; Thiazoles; Thiazolidines | 1993 |
Antihypertensive effects of a novel calcium antagonist, semotiadil fumarate (SD-3211), alone and in combination with enalapril or trichlormethiazide in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Enalapril; Heart Rate; Hypertension; Male; Rats; Rats, Inbred SHR; Thiazoles; Trichlormethiazide | 1994 |
Attenuation by R 56865, a novel cytoprotective drug, of regional myocardial ischemia- and reperfusion-induced electrocardiographic disturbances in anesthetized rabbits.
Topics: Analysis of Variance; Animals; Arrhythmias, Cardiac; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Heart; Hemodynamics; Injections, Intravenous; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Piperidines; Rabbits; Random Allocation; Thiazoles | 1995 |
Phosphodiesterase inhibitors reduce bronchial hyperreactivity and airway inflammation in unrestrained guinea pigs.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Administration, Inhalation; Analysis of Variance; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; Eosinophils; Guinea Pigs; Histamine; Hypersensitivity; Inflammation; Injections, Intraperitoneal; Isoenzymes; Macrophages; Male; Neutrophils; Ovalbumin; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrrolidinones; Rolipram; Specific Pathogen-Free Organisms; Theophylline; Thiazoles | 1995 |
Synthesis, anticonvulsant and neuroprotective activities of RP 66055, a riluzole derivative.
Topics: Animals; Anticonvulsants; Brain Ischemia; Corpus Striatum; Disease Models, Animal; Dopamine; Gerbillinae; Hypoxia, Brain; In Vitro Techniques; Male; Mice; Molecular Structure; Nervous System; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Seizures; Sodium Channel Blockers; Sodium Channels; Thiazoles | 1994 |
Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.
Topics: Animals; Blood Platelets; Cells, Cultured; Colitis; Dinoprostone; Disease Models, Animal; Humans; Leukotriene B4; Lipoxygenase Inhibitors; Male; Peritoneal Cavity; Rats; Rats, Inbred F344; Sheep; Structure-Activity Relationship; Thiazoles; Thromboxane B2; Thromboxane-A Synthase | 1994 |
[[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Hemoglobins; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Structure-Activity Relationship; Thiazoles | 1994 |
Preliminary observations on the effects of meloxicam in a new model for acute intra-articular inflammation in dogs.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Diatrizoate Meglumine; Disease Models, Animal; Dog Diseases; Dogs; Female; Leukocyte Count; Male; Meloxicam; Shoulder Joint; Synovial Fluid; Thiazines; Thiazoles | 1994 |
Comparison of electrophysiologic and hemodynamic effects of SD-3212, a new antiarrhythmic drug, and flecainide in a canine myocardial infarction model.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Output; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Flecainide; Heart Conduction System; Hemodynamics; Myocardial Infarction; Thiazoles | 1994 |
Effects of several partial dopamine D2 receptor agonists in Cebus apella monkeys previously treated with haloperidol.
Topics: Administration, Oral; Amphetamine; Animals; Antipsychotic Agents; Behavior, Animal; Benzothiazoles; Cebus; Disease Models, Animal; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dyskinesia, Drug-Induced; Dystonia; Ergolines; Female; Haloperidol; Lisuride; Male; Piperidines; Pramipexole; Quinpirole; Raclopride; Salicylamides; Thiazoles | 1993 |
Thiaproline reduces glomerular basement membrane thickness and collagen accumulation in the db/db mouse.
Topics: Animals; Antioxidants; Basement Membrane; Blood Glucose; Collagen; Diabetic Nephropathies; Disease Models, Animal; Female; Fructosamine; Hexosamines; Kidney; Kidney Glomerulus; Mice; Mice, Inbred Strains; Organ Size; Solubility; Thiazoles; Thiazolidines | 1994 |
The design and synthesis of second generation leukotriene B4 (LTB4) receptor antagonists related to SC-41930.
Topics: Animals; Benzopyrans; Binding Sites; Cell Degranulation; Chemotaxis, Leukocyte; Colitis; Dermatitis; Disease Models, Animal; Drug Design; Guinea Pigs; In Vitro Techniques; Leukotriene B4; Mice; Receptors, Leukotriene B4; Thiazoles | 1993 |
Effect of CL 184,005, a platelet-activating factor antagonist in a murine model of Staphylococcus aureus-induced gram-positive sepsis.
Topics: Animals; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enterotoxins; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Organophosphorus Compounds; Platelet Activating Factor; Staphylococcal Infections; Thiazoles; Time Factors; Tumor Necrosis Factor-alpha | 1994 |
A novel "patient-like" treatment model of human pancreatic cancer constructed using orthotopic transplantation of histologically intact human tumor tissue in nude mice.
Topics: Animals; Disease Models, Animal; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitomycin; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Pancreatic Neoplasms; Tetrazolium Salts; Thiazoles; Transplantation, Heterologous | 1993 |
Lipoprotein profile characterization of the KKA(y) mouse, a rodent model of type II diabetes, before and after treatment with the insulin-sensitizing agent pioglitazone.
Topics: Animals; Apolipoprotein A-I; Apolipoproteins B; Carrier Proteins; Cholesterol Ester Transfer Proteins; Diabetes Mellitus, Type 2; Disease Models, Animal; Glycoproteins; Hypoglycemic Agents; Lipoproteins; Lipoproteins, HDL; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Pioglitazone; Thiazoles; Thiazolidinediones | 1993 |
Dose-response relationship for the antipyretic effect of meloxicam in an endotoxin model in cats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Body Temperature; Cat Diseases; Cats; Cross-Over Studies; Disease Models, Animal; Dose-Response Relationship, Drug; Endotoxins; Escherichia coli; Female; Fever; Injections, Intravenous; Male; Meloxicam; Thiazines; Thiazoles | 1995 |
Pharmacological profile of semotiadil fumarate, a novel calcium antagonist, in rat experimental angina model.
Topics: Acetylcholine; Angina Pectoris; Animals; Arginine Vasopressin; Calcium Channel Blockers; Coronary Vessels; Diltiazem; Disease Models, Animal; Electrocardiography; Male; Nifedipine; Nisoldipine; Rats; Rats, Inbred Strains; Rats, Sprague-Dawley; Thiazoles; Vasoconstrictor Agents | 1995 |
VLDL triglyceride kinetics in Wistar fatty rats, an animal model of NIDDM: effects of dietary fructose alone or in combination with pioglitazone.
Topics: Animals; Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Disease Models, Animal; Energy Intake; Fatty Acids, Nonesterified; Fructose; Hypoglycemic Agents; Lipase; Lipoprotein Lipase; Lipoproteins, VLDL; Liver; Obesity; Pioglitazone; Rats; Rats, Wistar; Thiazoles; Thiazolidinediones; Thinness; Triglycerides | 1996 |
Effects of the antihypoxic and neuroprotective drug, lubeluzole, on repolarization phase of canine heart assessed by monophasic action potential recording.
Topics: Action Potentials; Animals; Blood Pressure; Cardiac Catheterization; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography; Heart; Heart Rate; Injections, Intravenous; Microelectrodes; Myocardium; Neuroprotective Agents; Piperidines; Rats; Thiazoles | 1996 |
A novel renal hypertensive guinea pig model for comparing different inhibitors of the renin-angiotensin system.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Dipeptides; Disease Models, Animal; Guinea Pigs; Heart Rate; Hypertension, Renal; Male; Pyridines; Renin; Renin-Angiotensin System; Thiazoles | 1996 |
Effects of moguisteine, a peripheral nonnarcotic antitussive agent, on airway inflammation in guinea-pigs in vivo.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents; Antitussive Agents; Bronchial Hyperreactivity; Capsaicin; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Inflammation; Male; Regression Analysis; Respiratory System; Smoke; Thiazoles; Thiazolidines | 1996 |
The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits.
Topics: Animals; Brain; Cerebral Infarction; Disease Models, Animal; Evoked Potentials, Somatosensory; Male; Neurons; Oxygen Consumption; Photobiology; Platelet Activating Factor; Pyridines; Rabbits; Thiazoles; Time Factors | 1996 |
A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats.
Topics: Animals; Blood Coagulation; Disease Models, Animal; Disseminated Intravascular Coagulation; Endotoxins; Female; Humans; Infant, Newborn; Platelet Activating Factor; Pulmonary Artery; Rats; Rats, Wistar; Respiratory Distress Syndrome, Newborn; Thiazoles; Thiazolidines | 1996 |
The effect of SM-8849 on experimental arthritis in mice.
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Antibody-Producing Cells; Arthritis; Biphenyl Compounds; Cattle; CD4 Antigens; Collagen; Disease Models, Animal; Enterotoxins; Hypersensitivity, Delayed; Immunity, Cellular; Immunization; Male; Mice; Mice, Inbred DBA; Prednisolone; Receptors, Interleukin-2; Superantigens; T-Lymphocytes; Thiazoles | 1996 |
Treatment of experimental focal ischemia in rats with lubeluzole.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Neuroprotective Agents; Piperidines; Rats; Thiazoles | 1996 |
Evaluating the antioxidant potential of new treatments for inflammatory bowel disease using a rat model of colitis.
Topics: Acetic Acid; Aminosalicylic Acids; Animals; Antioxidants; Butylated Hydroxytoluene; Colitis; Colitis, Ulcerative; Colon; Culture Techniques; Disease Models, Animal; Hydrocortisone; Luminescent Measurements; Male; Mesalamine; Rats; Rats, Wistar; Reactive Oxygen Species; Thiazoles | 1996 |
Metabolic effects of troglitazone in the Goto-Kakizaki rat, a non-obese and normolipidemic rodent model of non-insulin-dependent diabetes mellitus.
Topics: Animals; Chromans; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Hypoglycemic Agents; Injections, Intravenous; Insulin Resistance; Male; Rats; Rats, Inbred Strains; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 1997 |
Role of plasma insulin concentration in regulating glucose and lipid metabolism in lean and obese Zucker rats.
Topics: Administration, Oral; Animals; Blood Glucose; Cholesterol; Cholesterol, HDL; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acids, Nonesterified; Hypoglycemic Agents; Insulin; Lipid Metabolism; Lipids; Male; Mice; Mice, Inbred Strains; Obesity; Rats; Rats, Zucker; Thiazoles; Thiazolidines; Time Factors; Triglycerides | 1997 |
Quantification of the effects of troglitazone on insulin sensitivity and beta-cell function in Watanabe heritable hyperlipidemic rabbits: a minimal model analysis.
Topics: Animals; Blood Glucose; Chromans; Disease Models, Animal; Fasting; Female; Glucose Tolerance Test; Hypercholesterolemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Models, Biological; Rabbits; Random Allocation; Thiazoles; Thiazolidinediones; Time Factors; Troglitazone | 1997 |
Pharmacological reduction of electrophysiological diaschisis after photothrombotic ischemia in rat neocortex.
Topics: Animals; Cerebral Cortex; Dermatitis, Phototoxic; Disease Models, Animal; Dizocilpine Maleate; Electrophysiology; Evoked Potentials; Excitatory Amino Acid Antagonists; Intracranial Embolism and Thrombosis; Ischemic Attack, Transient; Male; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Thiazoles | 1997 |
A peptide sequence from platelet factor 4 (CT-112) is effective in the treatment of type II collagen induced arthritis in mice.
Topics: Administration, Oral; Amino Acid Sequence; Animals; Antibody Specificity; Arthritis, Reactive; Cell Division; Cells, Cultured; Collagen; Concanavalin A; Cytokines; Disease Models, Animal; Enzyme Inhibitors; Lipopolysaccharides; Mice; Mice, Inbred DBA; Mitogens; Peptide Fragments; Platelet Factor 4; Spleen; Tetrazolium Salts; Thiazoles; Thiazolidinediones | 1997 |
Electrophysiologic effects of SD-3212, a new class I antiarrhythmic drug, on canine atrial flutter and atrial action-potential characteristics.
Topics: Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Atrial Flutter; Atrial Function; Calcium Channel Blockers; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Electrophysiology; Heart Atria; Heart Conduction System; Sodium Channel Blockers; Thiazoles | 1997 |
Suppression of arthritis by the inhibitors of dipeptidyl peptidase IV.
Topics: Animals; Arthritis, Rheumatoid; Boronic Acids; Cells, Cultured; Collagen; Diamines; Dipeptides; Dipeptidyl Peptidase 4; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Hydroxylamines; Immunosuppressive Agents; Lymphocyte Activation; Lysine; Models, Immunological; Rats; Rats, Inbred F344; Rats, Inbred Lew; Serine Proteinase Inhibitors; T-Lymphocytes; Thiazoles | 1997 |
Effect of an insulin sensitizer, pioglitazone, on hypertension in fructose-drinking rats.
Topics: Animals; Blood Glucose; Blood Pressure; Disease Models, Animal; Drinking; Fructose; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Pioglitazone; Rats; Rats, Inbred WKY; Thiazoles; Thiazolidinediones; Time Factors; Triglycerides | 1997 |
OPC-6535, a superoxide anion production inhibitor, attenuates acute lung injury.
Topics: Administration, Inhalation; Animals; Anions; Bronchoalveolar Lavage Fluid; Cell Cycle; Disease Models, Animal; Endothelium; Hemodynamics; Integrins; Leukocyte Count; Lung Diseases; Neutrophil Activation; Neutrophils; Oxygen; Peroxidase; Pulmonary Circulation; Respiratory Burst; Sepsis; Superoxides; Swine; Thiazoles | 1997 |
The effect of (L)-cysteine and (L)-2-oxothiazolidine-4-carboxylic acid (OTZ) on urinary oxalate excretion: studies using a hyperoxaluric rat model.
Topics: Animals; Cysteine; Disease Models, Animal; Male; Oxalates; Pyrrolidonecarboxylic Acid; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Urinary Calculi | 1998 |
A rat model of chemical-induced polycystic kidney disease with multistage tumors.
Topics: Animals; Body Weight; Carcinogens; Disease Models, Animal; Kidney; Kidney Neoplasms; Kidney Tubules; Male; Nitrosamines; Polycystic Kidney Diseases; Rats; Rats, Sprague-Dawley; Thiazoles | 1998 |
Antitussive effect of moguisteine on allergic coughs in the guinea pig.
Topics: Analgesics, Opioid; Animals; Antitussive Agents; Codeine; Cough; Disease Models, Animal; Guinea Pigs; Hypersensitivity; Male; Thiazoles; Thiazolidines | 1998 |
Protective effects of a PAF receptor antagonist and a neutrophil elastase inhibitor on multiple organ failure induced by cerulein plus lipopolysaccharide in rats.
Topics: Alanine Transaminase; Amylases; Animals; Aspartate Aminotransferases; Blood Urea Nitrogen; Ceruletide; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kidney; Leukocyte Elastase; Lipase; Lipopolysaccharides; Liver; Lung; Male; Multiple Organ Failure; Organ Size; Pancreas; Pancreatitis; Piperazines; Platelet Membrane Glycoproteins; Pyridones; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Sulfonamides; Survival Rate; Thiazoles; Thiazolidines; Time Factors | 1998 |
Neuroprotective effect of 5-HT1A receptor agonist, Bay X 3702, demonstrated in vitro and in vivo.
Topics: Animals; Benzopyrans; Brain; Brain Ischemia; Cell Death; Cell Survival; Cells, Cultured; Cerebral Infarction; Disease Models, Animal; Dose-Response Relationship, Drug; Glutamic Acid; Hippocampus; Male; Neurons; Rats; Rats, Inbred F344; Rats, Long-Evans; Serotonin Receptor Agonists; Thiazoles | 1998 |
Discovery of FR115092: a novel antinephritic agent.
Topics: Anemia; Animals; Disease Models, Animal; Male; Mice; Nephritis; Pyridines; Thiazoles | 1998 |
Synthesis and effects of novel thiazole derivatives against thrombocytopenia.
Topics: Animals; Autoantibodies; Blood Platelets; Dapsone; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mitomycin; Models, Chemical; Purpura, Thrombocytopenic, Idiopathic; Pyridines; Thiazoles; Thrombocytopenia | 1998 |
Possible role of platelet-activating factor in the in vivo expression of tissue factor in neutrophils.
Topics: Animals; Aspartate Aminotransferases; Blood Coagulation; Cholangitis; Disease Models, Animal; Leukocytes; Liver; Male; Neutrophils; Platelet Activating Factor; Rabbits; Thiazoles; Thiazolidines; Thromboplastin | 1998 |
Combination treatment with troglitazone, an insulin action enhancer, and pravastatin, an inhibitor of HMG-CoA reductase, shows a synergistic effect on atherosclerosis of WHHL rabbits.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Blood Glucose; Cholesterol, LDL; Chromans; Coronary Vessels; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Female; Glucose Tolerance Test; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperinsulinism; Hyperlipoproteinemia Type II; Hypoglycemic Agents; Insulin Resistance; Male; Pravastatin; Rabbits; Thiazoles; Thiazolidinediones; Troglitazone; Xanthomatosis | 1999 |
Mechanism of the uricosuric action of the anti-inflammatory drug E3040 used to treat inflammatory bowel disease I: study using a rat model of hyperuricemia.
Topics: Animals; Benzothiazoles; Disease Models, Animal; Inflammatory Bowel Diseases; Inulin; Kidney Tubules, Proximal; Lipoxygenase Inhibitors; Male; Pyridines; Rats; Rats, Wistar; Thiazoles; Thromboxane-A Synthase; Uric Acid; Uricosuric Agents | 1999 |
The antithrombotic efficacy of the GP IIb/IIIa antagonist SR121787 is potentiated by antithrombin-dependent factor Xa inhibition without an increase in the bleeding risk in the rabbit.
Topics: Animals; Anticoagulants; Antithrombins; Benzylamines; Carotid Arteries; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Factor Xa Inhibitors; Fibrinolytic Agents; Hemorrhage; Heparin; Male; Oligosaccharides; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Thiazoles | 1999 |
Effects of lipid mediator antagonists on predominant mediator-controlled asthmatic reactions in passively sensitized guinea pigs.
Topics: Administration, Oral; Animals; Asthma; Chromones; Disease Models, Animal; Guinea Pigs; Immunization, Passive; Leukotriene Antagonists; Leukotrienes; Male; Membrane Proteins; Phenylacetates; Receptors, Leukotriene; Receptors, Thromboxane; Serum Albumin, Bovine; Sulfonamides; Tetrazoles; Thiazoles; Thromboxane A2; Thromboxane B2 | 1999 |
Effect of ebrotidine on gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide.
Topics: Acute Disease; Animals; Anti-Ulcer Agents; Benzenesulfonates; Disease Models, Animal; Gastric Mucosa; Gastritis; Helicobacter Infections; Helicobacter pylori; Lipopolysaccharides; Rats; Rats, Sprague-Dawley; Thiazoles | 1999 |
Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusion-induced gastric lesions.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Gastric Mucosa; Gastrins; Gene Expression Regulation, Enzymologic; Indomethacin; Interleukin-1; Isoenzymes; Lactones; Meloxicam; Membrane Proteins; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Regional Blood Flow; Reperfusion Injury; Resveratrol; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stilbenes; Stomach Ulcer; Sulfonamides; Sulfones; Thiazines; Thiazoles; Time Factors | 1999 |
Therapeutic index for rosiglitazone in dietary obese rats: separation of efficacy and haemodilution.
Topics: Animals; Body Weight; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Hemodilution; Hemodynamics; Hypoglycemic Agents; Insulin; Leptin; Male; Obesity; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Thiazolidinediones | 1999 |
Influence of application vehicle on skin sensitization to methylchloroisothiazolinone/methylisothiazolinone: an analysis using the local lymph node assay.
Topics: Allergens; Animals; Dermatitis, Allergic Contact; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Lymph Nodes; Mice; Mice, Inbred CBA; Patch Tests; Pharmaceutical Vehicles; Thiazoles | 1999 |
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Benzothiazoles; Disease Models, Animal; Genetic Predisposition to Disease; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Nerve Degeneration; Neurites; Plaque, Amyloid; Protein Isoforms; Thiazoles; Time Factors | 2000 |
Neuroprotective effects of kynurenine-3-hydroxylase inhibitors in models of brain ischemia.
Topics: Alanine; Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Gerbillinae; Hippocampus; In Vitro Techniques; Ischemic Attack, Transient; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Wistar; Sulfonamides; Thiazoles | 1999 |
Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine.
Topics: Animals; Anti-Ulcer Agents; Benzenesulfonates; Disease Models, Animal; Gastric Juice; Histamine H2 Antagonists; Indomethacin; Male; Omeprazole; Ranitidine; Rats; Rats, Sprague-Dawley; Stomach Ulcer; Thiazoles | 2000 |
Antithrombotic and hemostatic capacity of factor Xa versus thrombin inhibitors in models of venous and arteriovenous thrombosis.
Topics: Amino Acid Chloromethyl Ketones; Animals; Anticoagulants; Antithrombins; Arteriovenous Shunt, Surgical; Bleeding Time; Disease Models, Animal; Dose-Response Relationship, Drug; Enoxaparin; Factor Xa Inhibitors; Fibrinolytic Agents; Hemostatics; Heparin; Male; Oligopeptides; Rabbits; Serine Proteinase Inhibitors; Thiazoles; Thrombin; Thrombosis; Venous Thrombosis | 2000 |
Involvement of ATP-sensitive K(+) channels in the anti-tussive effect of moguisteine.
Topics: Animals; Antitussive Agents; ATP-Binding Cassette Transporters; Cough; Disease Models, Animal; Drug Interactions; Glyburide; Guinea Pigs; KATP Channels; Male; Pinacidil; Potassium Channels; Potassium Channels, Inwardly Rectifying; Thiazoles; Thiazolidines | 2000 |
Down-regulation by troglitazone of hepatic tumor necrosis factor-alpha and interleukin-6 mRNA expression in a murine model of non-insulin-dependent diabetes.
Topics: Animals; Chromans; Diabetes Mellitus, Type 2; Disease Models, Animal; Down-Regulation; Gene Expression; Hypoglycemic Agents; Interleukin-6; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred C57BL; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Tumor Necrosis Factor-alpha | 2000 |
Selective cyclooxygenase-2 inhibition prevents alveolar bone loss in experimental periodontitis in rats.
Topics: Alveolar Bone Loss; Alveolar Process; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Cell Count; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Indomethacin; Injections, Subcutaneous; Isoenzymes; Leukocyte Count; Leukocytes, Mononuclear; Leukocytosis; Male; Meloxicam; Molar; Neutrophils; Osteoclasts; Periodontitis; Peroxidases; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Stomach; Thiazines; Thiazoles; Tooth Cervix | 2000 |
Effect of aspirin on platelet desaggregation induced by SR121566, a potent GP-IIb/IIIa antagonist.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Aspirin; Benzylamines; Blood Flow Velocity; Blood Platelets; Carotid Arteries; Disease Models, Animal; Electric Stimulation; Female; Fibrinolytic Agents; Humans; Male; Oligopeptides; Piperidines; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Rabbits; Recombinant Proteins; Thiazoles; Thrombosis; Thrombospondins; Tissue Plasminogen Activator | 2000 |
In vitro and in vivo activities of nitazoxanide against Clostridium difficile.
Topics: Animals; Anti-Bacterial Agents; Clindamycin; Clostridioides difficile; Cricetinae; Disease Models, Animal; Enterocolitis, Pseudomembranous; Metronidazole; Microbial Sensitivity Tests; Nitro Compounds; Thiazoles; Vancomycin | 2000 |
Ex vivo antisense oligonucleotides to proliferating cell nuclear antigen and Cdc2 kinase inhibit graft coronary artery disease.
Topics: Actins; Animals; CDC2 Protein Kinase; Cell Division; Cells, Cultured; Coronary Disease; Disease Models, Animal; Heart Transplantation; Humans; Immunohistochemistry; Macrophages; Male; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Polymerase Chain Reaction; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred ACI; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2000 |
Efficacies of two new antifungal agents, the triazole ravuconazole and the echinocandin LY-303366, in an experimental model of invasive aspergillosis.
Topics: Anidulafungin; Animals; Antibiotic Prophylaxis; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Brain; Disease Models, Animal; Echinocandins; Liver; Lung; Peptides, Cyclic; Rabbits; Thiazoles; Triazoles | 2000 |
Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones.
Topics: Adipose Tissue; Animals; Blood Glucose; Chromans; Diabetes Mellitus, Lipoatrophic; Disease Models, Animal; Female; Hypoglycemic Agents; Insulin; Ligands; Liver; Mice; Mice, Inbred C57BL; Mice, Transgenic; Receptors, Cytoplasmic and Nuclear; Respiratory Function Tests; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Triglycerides; Troglitazone | 2000 |
Troglitazone prevents fatty changes of the liver in obese diabetic rats.
Topics: Age Factors; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Cholesterol; Chromans; Colon; Colonic Polyps; Data Interpretation, Statistical; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Liver; Hyperlipidemias; Hypoglycemic Agents; Insulin; Liver; Male; Organ Size; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Thiazoles; Thiazolidinediones; Time Factors; Triglycerides; Troglitazone | 2000 |
Troglitazone halts diabetic glomerulosclerosis by blockade of mesangial expansion.
Topics: Animals; Basement Membrane; Body Weight; Chondroitin Sulfate Proteoglycans; Chromans; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Fibrosis; Glomerular Mesangium; Hyperglycemia; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Islets of Langerhans; Rats; Rats, Zucker; Thiazoles; Thiazolidinediones; Troglitazone | 2000 |
UCP3 gene expression does not correlate with muscle oxidation rates in troglitazone-treated Zucker fatty rats.
Topics: Animals; Antioxidants; Body Weight; Carbon Dioxide; Carrier Proteins; Chromans; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Metabolism; Fatty Acids; Gene Expression Regulation; Glucose; Insulin Resistance; Ion Channels; Mitochondrial Proteins; Muscle, Skeletal; Rats; Rats, Zucker; RNA, Messenger; Thiazoles; Thiazolidinediones; Troglitazone; Uncoupling Protein 3 | 2000 |
Inhibition of evoked glutamate release by the neuroprotective 5-HT(1A) receptor agonist BAY x 3702 in vitro and in vivo.
Topics: Animals; Aspartic Acid; Benzopyrans; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Space; Glutamic Acid; Hippocampus; Infarction, Middle Cerebral Artery; Male; Microdialysis; Neuroprotective Agents; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Receptor Agonists; Synaptic Transmission; Thiazoles | 2001 |
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Disease Models, Animal; Disease Progression; Feedback; Fluorescent Dyes; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy; Plaque, Amyloid; Thiazoles | 2001 |
Inhibition of the cyclooxygenase isoenzymes COX-1 and COX-2 provide neuroprotection in the MPTP-mouse model of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; 3,4-Dihydroxyphenylacetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cell Count; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Dopamine; Homovanillic Acid; Isoenzymes; Male; Meloxicam; Membrane Proteins; Mice; Mice, Inbred C57BL; Motor Activity; Neostriatum; Neuroprotective Agents; Parkinsonian Disorders; Prostaglandin-Endoperoxide Synthases; Substantia Nigra; Thiazines; Thiazoles; Tyrosine 3-Monooxygenase | 2001 |
Improvement of left ventricular diastolic dynamics in prediabetic stage of a type II diabetic rat model after troglitazone treatment.
Topics: Animals; Blood Pressure; Chromans; Diastole; Disease Models, Animal; Echocardiography, Doppler; Heart Rate; Hypoglycemic Agents; Male; Prediabetic State; Random Allocation; Rats; Rats, Inbred OLETF; Thiazoles; Thiazolidinediones; Troglitazone; Ventricular Function, Left | 2001 |
Kynurenine 3-mono-oxygenase activity and neurotoxic kynurenine metabolites increase in the spinal cord of rats with experimental allergic encephalomyelitis.
Topics: Animals; Astrocytes; Brain; Cytoplasmic Granules; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Female; Immunohistochemistry; Kynurenic Acid; Kynurenine; Kynurenine 3-Monooxygenase; Mixed Function Oxygenases; Multiple Sclerosis; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Spinal Cord; Sulfonamides; Thiazoles | 2001 |
Expression and function of peroxisome proliferator-activated receptor-gamma in mesangial cells.
Topics: Animals; Cell Nucleus; Cells, Cultured; Chromans; Cytoplasm; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Fibrinolysin; Glomerular Mesangium; Matrix Metalloproteinase Inhibitors; Plasminogen Activator Inhibitor 1; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Obese; Oxadiazoles; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 2001 |
Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Disease Models, Animal; Gene Expression; Glucose Tolerance Test; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Liver; Male; Muscle, Skeletal; Nicotinic Acids; Obesity; Rats; Rats, Zucker; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; RNA, Messenger; Rosiglitazone; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors | 2001 |
2,4-Thiazolidinediones as potent and selective human beta3 agonists.
Topics: Adrenergic beta-3 Receptor Agonists; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Humans; Mice; Mice, Knockout; Mice, Transgenic; Obesity; Structure-Activity Relationship; Thiazoles; Thiazolidinediones | 2001 |
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.
Topics: Amyloid beta-Peptides; Animals; Antineoplastic Agents; Benzothiazoles; Brain Ischemia; Caspase 3; Caspases; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; DNA; Dose-Response Relationship, Drug; Glutamic Acid; Kainic Acid; Mice; Mice, Inbred C57BL; Mitochondria; Neurons; Prodrugs; Rats; Rats, Sprague-Dawley; Seizures; Thiazoles; Toluene; Tumor Suppressor Protein p53 | 2001 |
Peroxisome proliferator-activated receptor-gamma agonist troglitazone protects against nondiabetic glomerulosclerosis in rats.
Topics: Animals; Antihypertensive Agents; Base Sequence; Chromans; Disease Models, Animal; DNA Primers; Glomerulosclerosis, Focal Segmental; Hypoglycemic Agents; Insulin Resistance; Kidney; Lipids; Macrophages; Male; Nephrectomy; Plasminogen Activator Inhibitor 1; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Thiazoles; Thiazolidinediones; Transcription Factors; Transforming Growth Factor beta; Troglitazone | 2001 |
BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Survival; Colonic Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Female; Humans; Infusions, Parenteral; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Ovarian Neoplasms; Paclitaxel; Pancreatic Neoplasms; Sarcoma; Thiazoles; Tubulin; Tumor Cells, Cultured; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2001 |
Effects of steroidal and non-steroidal antiphlogistic drugs on eicosanoid synthesis in irritated skin: studies with the isolated perfused bovine udder.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Cattle; Clobetasol; Clonixin; Culture Techniques; Dinoprostone; Disease Models, Animal; Eicosanoids; Female; Glucocorticoids; Indomethacin; Mammary Glands, Animal; Meloxicam; Skin Physiological Phenomena; Thiazines; Thiazoles | 2001 |
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.
Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Degeneration; Neurofibrillary Tangles; Oxidative Stress; Thiazoles; Tyrosine | 2001 |
Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cell Count; Data Interpretation, Statistical; Disease Models, Animal; Hippocampus; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Plaque, Amyloid; Reproducibility of Results; Statistical Distributions; Thiazoles | 2001 |
Synthesis and QSAR studies in 2-(N-aryl-N-aroyl)amino-4,5-dihydrothiazole derivatives as potential antithrombotic agents.
Topics: Animals; Crystallography, X-Ray; Disease Models, Animal; Fibrinolytic Agents; Mice; Models, Molecular; Quantitative Structure-Activity Relationship; Thiazoles; Thrombosis | 2001 |
3-Arylsulphonyl-5-arylamino-1,3,4-thiadiazol-2(3H)ones as anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Female; Male; Mice; Pain; Rats; Sulfur Compounds; Thiazoles | 2001 |
PPARgamma and inflammatory bowel disease: a new therapeutic target for ulcerative colitis and Crohn's disease.
Topics: Animals; Anti-Inflammatory Agents; Chromans; Colitis, Ulcerative; Crohn Disease; Disease Models, Animal; Inflammation; Intestines; Ligands; Mice; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2001 |
A comparison of the effects of troglitazone and vitamin E on the fatty acid composition of serum phospholipids in an experimental model of insulin resistance.
Topics: Animals; Antioxidants; Blood Glucose; Blood Pressure; Chromans; Disease Models, Animal; Fatty Acids; Female; Hyperinsulinism; Hypertriglyceridemia; Hypoglycemic Agents; Insulin Resistance; Rats; Rats, Mutant Strains; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone; Vitamin E | 2001 |
Cell death associated with genetic prodrug activation therapy of colorectal cancer.
Topics: Adenoviridae; Animals; Cell Cycle; Cell Death; Colorectal Neoplasms; Disease Models, Animal; DNA Fragmentation; Flow Cytometry; Ganciclovir; Genetic Therapy; Genetic Vectors; Humans; Mice; Neoplasm Transplantation; Phosphorylation; Prodrugs; Simplexvirus; Tetrazolium Salts; Thiazoles; Thymidine Kinase; Transduction, Genetic; Tumor Cells, Cultured | 2001 |
Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau.
Topics: Animals; Benzothiazoles; Brain; Cerebral Cortex; Coloring Agents; Congo Red; Disease Models, Animal; Female; Gene Expression Regulation; Hippocampus; Humans; Immunohistochemistry; Male; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microscopy, Electron; Mutation, Missense; Neurodegenerative Diseases; Neurofibrillary Tangles; Neurons; Protein Structure, Secondary; tau Proteins; Thiazoles; Transfection; Ubiquitin | 2001 |
Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Congo Red; Disease Models, Animal; Gene Expression Regulation, Developmental; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microscopy, Electron; Mutagenesis, Insertional; Mutation; Neurites; Neurons; Peptide Fragments; Plaque, Amyloid; Presynaptic Terminals; Promoter Regions, Genetic; Thiazoles | 2001 |
Efficacy of ravuconazole (BMS-207147) in a guinea pig model of disseminated aspergillosis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disease Models, Animal; Drug Evaluation, Preclinical; Guinea Pigs; Humans; Male; Organ Culture Techniques; Organ Specificity; Thiazoles; Triazoles | 2002 |
[Chemical-induced polycyst with renal tumor and expression of 8-OHdG in kidney tissue].
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Carcinoma, Renal Cell; Deoxyguanosine; Disease Models, Animal; Kidney Neoplasms; Male; Nitrosamines; Polycystic Kidney Diseases; Rats; Rats, Sprague-Dawley; Thiazoles | 2000 |
Amyloid-beta deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition.
Topics: Aging; alpha 1-Antichymotrypsin; Amyloid beta-Peptides; Animals; Apolipoproteins E; Benzothiazoles; Brain Diseases; Callithrix; Cerebral Cortex; Cholinesterases; Disease Models, Animal; Female; Incidence; Male; Neurites; Peptide Fragments; Plaque, Amyloid; Survival Analysis; Thiazoles | 2002 |
Exercise-induced apoptosis of rat skeletal muscle and the effect of meloxicam.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Culture Techniques; Disease Models, Animal; Male; Meloxicam; Muscle, Skeletal; Physical Conditioning, Animal; Probability; Random Allocation; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Thiazines; Thiazoles | 2002 |
Thiazolidinedione derivatives as novel therapeutic agents to prevent the development of chronic pancreatitis.
Topics: Amylases; Animals; Antineoplastic Agents; Blood Glucose; Chromans; Chronic Disease; Disease Models, Animal; DNA; Gene Expression; Hypoglycemic Agents; Insulin; Interleukin-8; Macrophages, Peritoneal; Male; Organ Size; Pancreatitis; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Necrosis Factor-alpha | 2002 |
Nociceptive behaviour induced by dental application of irritants to rat incisors: a new model for tooth inflammatory pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Crowns; Cyclooxygenase Inhibitors; Dental Pulp Cavity; Disease Models, Animal; Drug Interactions; Female; Formaldehyde; Gingiva; Inflammation; Male; Meloxicam; Morphine; Naloxone; Narcotic Antagonists; Nerve Fibers; Nociceptors; Pain Measurement; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles; Toothache | 2002 |
Peroxisome proliferator-activated receptor gamma plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo.
Topics: Actins; Angiotensin II; Animals; Atrial Natriuretic Factor; Body Weight; Cardiomegaly; Cell Size; Cells, Cultured; Chromans; Disease Models, Animal; Gene Expression; Heart; Heterozygote; Hypoglycemic Agents; Ligands; Mice; Mice, Knockout; Myocardium; Organ Size; Pioglitazone; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2002 |
Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease.
Topics: Animals; Antiviral Agents; Disease Models, Animal; DNA Helicases; DNA Primase; Drug Design; Enzyme Inhibitors; Female; Herpes Genitalis; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; In Vitro Techniques; Mice; Mice, Hairless; Pyridines; Thiazoles; Viral Proteins | 2002 |
Neostigmine interactions with non steroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Diclofenac; Disease Models, Animal; Drug Synergism; Ketoprofen; Meloxicam; Mice; Neostigmine; Pain; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Thiazines; Thiazoles | 2002 |
Troglitazone improves GLUT4 expression in adipose tissue in an animal model of obese type 2 diabetes mellitus.
Topics: Adipose Tissue; Animals; Blood Glucose; Cholesterol; Chromans; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Fatty Acids, Nonesterified; Gene Expression Regulation; Glucose Transporter Type 4; Hypoglycemic Agents; Insulin; Male; Monosaccharide Transport Proteins; Muscle Proteins; Obesity; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Reference Values; Thiazoles; Thiazolidinediones; Triglycerides; Troglitazone | 2002 |
Troglitazone enhances the hepatotoxicity of acetaminophen by inducing CYP3A in rats.
Topics: Acetaminophen; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Chromans; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Hypoglycemic Agents; Injections, Intraperitoneal; Male; Oxidoreductases, N-Demethylating; Rats; Rats, Mutant Strains; Rats, Wistar; Thiazoles; Thiazolidinediones; Troglitazone | 2002 |
Normalization of skeletal muscle glycogen synthesis and glycolysis in rosiglitazone-treated Zucker fatty rats: an in vivo nuclear magnetic resonance study.
Topics: Animals; Disease Models, Animal; Gluconeogenesis; Glycolysis; Kinetics; Magnetic Resonance Spectroscopy; Models, Biological; Muscle, Skeletal; Obesity; Rats; Rats, Zucker; Reference Values; Rosiglitazone; Thiazoles; Thiazolidinediones | 2002 |
Carcinoma of the urinary bladder.
Topics: Animals; Carcinoma, Transitional Cell; Disease Models, Animal; FANFT; Humans; Rats; Rats, Inbred F344; Thiazoles; Urinary Bladder Neoplasms | 1979 |
Induction of transitional cell carcinoma of the urinary bladder in rats by feeding N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide. Histological and ultrastructural findings.
Topics: Animals; Carcinoma, Transitional Cell; Disease Models, Animal; Epithelium; FANFT; Female; Neoplasms, Experimental; Organ Size; Rats; Thiazoles; Urinary Bladder; Urinary Bladder Neoplasms | 1978 |
FANFT-induced bladder tumors.
Topics: Animals; Disease Models, Animal; FANFT; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Neoplasms, Experimental; Thiazoles; Urinary Bladder Neoplasms | 1976 |
Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodies.
Topics: 3T3 Cells; Animals; Antibodies, Monoclonal; Cell Division; Colorimetry; Disease Models, Animal; Gene Expression; Humans; Immunization; Immunotherapy; Mice; Mice, Nude; Neoplasm Transplantation; Proto-Oncogene Proteins; Receptor, ErbB-2; Stomach Neoplasms; Tetrazolium Salts; Thiazoles; Transplantation, Heterologous; Tumor Cells, Cultured | 1992 |
Development of an animal model of late asthmatic response in guinea pigs and effects of anti-asthmatic drugs.
Topics: Albuterol; Allergens; Animals; Asthma; Bronchoalveolar Lavage Fluid; Cromolyn Sodium; Cytodiagnosis; Disease Models, Animal; Guinea Pigs; Immunization; Male; Respiratory Mechanics; Theophylline; Thiazoles; Time Factors | 1992 |
Effects of drugs on ventricular fibrillation and ischaemic K+ loss in a model of ischaemia in perfused guinea-pig hearts in vitro.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium Channel Blockers; Disease Models, Animal; Glipizide; Glyburide; Guinea Pigs; In Vitro Techniques; Male; Myocardial Ischemia; Piperidines; Potassium; Potassium Channels; Pyrazines; Pyridines; Sympatholytics; Thiazoles; Ventricular Fibrillation | 1992 |
[Structure and function of the experimental polycystic kidney induced by diphenylthiazole with special reference to renal micropuncture study].
Topics: Animals; Disease Models, Animal; Hyperplasia; Kidney; Male; Microscopy, Electron; Polycystic Kidney Diseases; Punctures; Rats; Rats, Sprague-Dawley; Thiazoles; Urodynamics | 1992 |
Neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Electroencephalography; Gerbillinae; Ischemic Attack, Transient; Male; Rats; Riluzole; Thiazoles | 1992 |
Ouabain-induced changes of calcium and potassium in slices of hippocampus of the rat: comparison to hypoxia and effect of R 56865.
Topics: Animals; Benzothiazoles; Brain Ischemia; Calcium; Disease Models, Animal; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Male; Ouabain; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles | 1992 |
Hepatoprotective effects of 1-[(2-thiazolin-2-yl)-amino]acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5- tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) in various experimental liver injuries.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzazepines; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Ethionine; Galactosamine; Lipopolysaccharides; Liver; Male; Mice; Mice, Inbred BALB C; Propionibacterium acnes; Rats; Rats, Inbred Strains; Thiazoles; Triglycerides | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 1. Effect on passive anaphylactic bronchoconstriction in guinea pigs.
Topics: Anaphylaxis; Animals; Asthma; Bronchoconstriction; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Indomethacin; Male; Ovalbumin; Platelet Activating Factor; Propranolol; Pyrilamine; SRS-A; Thiazoles; Thiazolidines | 1991 |
Effect of the selective PAF antagonist SM-10661 on an asthmatic model. 2. Effect on antigen-induced dual asthmatic response and infiltration of leukocytes into airways in actively sensitized conscious guinea pigs.
Topics: Animals; Antigens; Asthma; Cromolyn Sodium; Disease Models, Animal; Fenoterol; Guinea Pigs; Leukocytes; Lung; Male; Ovalbumin; Platelet Activating Factor; Respiratory Function Tests; Respiratory System; Thiazoles; Thiazolidines | 1991 |
Anticonvulsant and sleep-waking influences of riluzole in a rat model of absence epilepsy.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Circadian Rhythm; Disease Models, Animal; Electromyography; Epilepsy, Absence; Male; Rats; Rats, Inbred Strains; Riluzole; Sleep; Thiazoles; Wakefulness | 1991 |
Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat.
Topics: Animals; Azepines; Disease Models, Animal; Glomerulonephritis, Membranous; Hypercholesterolemia; Male; Metabolic Clearance Rate; Methylprednisolone; Piperazines; Platelet Activating Factor; Proteinuria; Puromycin Aminonucleoside; Rats; Rats, Inbred Strains; Thiazoles; Thiazolidines; Ticlopidine; Triazoles | 1991 |
Therapeutic intervention in a rat model of ARDS: I. Dual inhibition of arachidonic acid metabolism.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Bronchoalveolar Lavage Fluid; Capillary Permeability; Disease Models, Animal; Erythrocyte Count; Escherichia coli; Hematocrit; Hemoglobins; Imidazoles; Leukocyte Count; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Methylprednisolone; Neutrophils; Platelet Count; Rats; Rats, Inbred Strains; Respiratory Distress Syndrome; Thiazoles | 1990 |
Protective effect of SK&F 86002, a novel dual inhibitor of arachidonic acid metabolism, in murine models of endotoxin shock: inhibition of tumor necrosis factor as a possible mechanism of action.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Dexamethasone; Disease Models, Animal; Galactosamine; Imidazoles; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Propionibacterium acnes; Shock, Septic; Thiazoles; Tumor Necrosis Factor-alpha | 1989 |
[Preparation of cerebral ischemia-induced amnesic model in mice and ameliorative effect of several compounds on the model].
Topics: Amnesia; Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Male; Mice; Mice, Inbred ICR; Pyrrolidinones; Thiazoles; Thiazolidines | 1989 |
A non-human primate model for the study of oral iron chelators.
Topics: Administration, Oral; Animals; Cebus; Deferoxamine; Dihydropyridines; Disease Models, Animal; Injections, Intramuscular; Iron; Iron Chelating Agents; Thiazoles | 1989 |
Short-term primary culture of rat prostate tumor epithelial cells on reconstituted basement membrane as a useful in vitro model to assess drug action on prostatic cancer: efficacy of the thiazolidinedione derivative CGP 19984.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Basement Membrane; Disease Models, Animal; Epithelium; Male; Prostatic Neoplasms; Rats; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1989 |
A PAF-acether antagonist (N 48740 RP/Rhône-Poulenc) and laser-induced thrombi in rat mesenteric vessels.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents; Lasers; Male; Mesenteric Arteries; Platelet Activating Factor; Platelet Aggregation Inhibitors; Pyridines; Rats; Rats, Inbred Strains; Thiazoles; Thrombosis | 1989 |
The hypoglycemic effect of ciglitazone in obese, hyperglycemic animal models.
Topics: Adipose Tissue; Adipose Tissue, Brown; Animals; Blood Glucose; Disease Models, Animal; Glycolysis; Hyperglycemia; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Obese; Mitochondria; Obesity; Oxygen Consumption; Receptor, Insulin; Thiazoles; Thiazolidinediones | 1988 |
Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists.
Topics: Animals; Blood Pressure; Disease Models, Animal; Diterpenes; Escherichia coli Infections; Ethanol; Ginkgolides; Glyceryl Ethers; Intestine, Small; Lactones; Lipopolysaccharides; Male; Peptic Ulcer; Peptic Ulcer Hemorrhage; Phospholipid Ethers; Plant Extracts; Platelet Activating Factor; Rats; Rats, Inbred Strains; Shock, Septic; Stomach; Thiazoles | 1987 |
[Anti-ulcer mechanism of mezolidon on water-immersion stress induced gastric ulcers in rats].
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Duodenum; Gastric Mucosa; Immersion; Male; Peptic Ulcer; Rats; Rats, Inbred Strains; Regional Blood Flow; Thiazoles | 1988 |
On the anti-inflammatory properties of the schistosomicide niridazole (Ambilhar).
Topics: Animals; Anthelmintics; Anti-Inflammatory Agents; Arthritis; Disease Models, Animal; Dracunculiasis; Edema; Imidazoles; Kaolin; Niridazole; Pleurisy; Rats; Thiazoles; Turpentine | 1971 |
The nature of a drug-induced renal concentrating defect in rats.
Topics: Amines; Animals; Biological Transport; Carbon Radioisotopes; Dehydration; Disease Models, Animal; Glomerular Filtration Rate; Inulin; Kidney; Kidney Concentrating Ability; Kidney Cortex; Kidney Diseases; Kidney Medulla; Kidney Tubules; Male; Microscopy, Electron; Osmolar Concentration; Photometry; Potassium; Punctures; Quaternary Ammonium Compounds; Rats; Sodium; Thiazoles; Urea; Vasopressins; Water | 1974 |
Experimental models for the evaluation of systemic trichomonacides. Models for evaluation of trichomonacides.
Topics: Acetamides; Alkynes; Animals; Antitrichomonal Agents; Disease Models, Animal; Male; Metronidazole; Mice; Nitro Compounds; Nitroimidazoles; Scrotum; Sulfones; Thiazoles; Trichomonas; Trichomonas Infections; Trichomonas vaginalis | 1973 |
Carcinostatic activity of a thiazolidinonylidene-hydrazonothiazolidinone derivative against DMBA-induced mammary carcinomata in female Sprague-Dawley rats.
Topics: Animals; Antineoplastic Agents; Benz(a)Anthracenes; Breast Neoplasms; Carcinoma; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hydrazones; Neoplasms, Experimental; Rats; Thiazoles | 1973 |
The use of N-(4-(5-nitro-2-furyl)-2-thiazolyl) formamide in the study of bladder cancer.
Topics: Amides; Animals; Carcinogens; Disease Models, Animal; Formamides; Neoplasms, Experimental; Nitrofurans; Rats; Solvents; Thiazoles; Urinary Bladder Neoplasms | 1972 |
Anthelmintic studies with pyrantel. II. Prophylactic activity in a mouse-ascaris suum test model.
Topics: Animal Feed; Animals; Anthelmintics; Ascariasis; Ascaris; Azoles; Disease Models, Animal; Female; Intestine, Small; Larva; Lung; Male; Metamorphosis, Biological; Mice; Ovum; Piperazines; Pyrimidines; Thiazoles; Time Factors | 1971 |
The efficacy of various anthelmintics against the parasitic larval stages of Ancylostoma caninum in Mastomys natalensis.
Topics: Ancylostoma; Animals; Anthelmintics; Benzene Derivatives; Benzimidazoles; Carbamates; Disease Models, Animal; Larva; Muscles; Organophosphonates; Pyridines; Rats; Thiabendazole; Thiazoles; Thiocyanates | 1970 |