Page last updated: 2024-08-21

thiazoles and Cystic Fibrosis

thiazoles has been researched along with Cystic Fibrosis in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.86)	18.7374
1990's	3 (8.57)	18.2507
2000's	6 (17.14)	29.6817
2010's	21 (60.00)	24.3611
2020's	4 (11.43)	2.80

Authors

Authors	Studies
Baroni, D; Brandas, C; Cichero, E; Ludovico, A; Millo, E; Moran, O; Parodi, A	1
Amico, G; Baroni, D; Brandas, C; Moran, O	1
Cichero, E; Damonte, G; Liessi, N; Millo, E; Pedemonte, N; Pesce, E; Salis, A; Tasso, B	1
Leoni, A; Locatelli, A; Morigi, R; Pedemonte, N; Pesce, E	1
Barraja, P; Barreca, M; Cilibrasi, V; Galietta, LJV; Genovese, M; Montalbano, A; Renda, M; Spanò, V	1
Arkel, M; Cichero, E; Damonte, G; Fossa, P; Galietta, LJV; Liessi, N; Millo, E; Paccagnella, M; Pedemonte, N; Pesce, E; Salis, A; Tasso, B; Tomati, V	1
Bugatti, A; Cichero, E; D'Ursi, P; Di Somma, M; Fossa, P; Galietta, LJV; Milanesi, L; Millo, E; Orro, A; Rusnati, M; Sala, D; Trombetti, G; Urbinati, C	1
Bear, CE; Casavola, V; Laselva, O; Molinski, S	1
Barraja, P; Carbone, A; Galietta, LJV; Montalbano, A; Scudieri, P; Spanò, V	1
Bartlett, MC; Clarke, DM; Loo, TW	1
El-Badri, F; Hu, B; Hudson, BM; Kurth, MJ; Phuan, PW; Tantillo, DJ; Verkman, AS; Ye, L	1
Anzaldi, M; Galietta, LJ; Mazzei, M; Mazzei, MT; Nieddu, E; Pedemonte, N; Pesce, E; Pollarolo, B; Schenone, S	1
Bellotti, M; Cichero, E; Damonte, G; Fossa, P; Galatini, A; Galietta, LJ; Gianotti, A; Guariento, S; Liessi, N; Millo, E; Pedemonte, N; Pesce, E; Salis, A; Zegarra-Moran, O	1
Beekman, JM; de Winter-de Groot, KM; Dekkers, JF; Gogorza Gondra, RA; Janssens, HM; Kruisselbrink, E; van der Ent, CK; Vonk, AM	1
Bali, V; Bebok, Z; Guroji, P; Lazrak, A; Matalon, S	1
Buzid, A; Glennon, JD; Hayes, PE; Luong, JH; McGlacken, GP; Muimhneacháin, EÓ; O'Gara, F; Pardo, LM; Reen, FJ; Shang, F; Sperry, J	1
El-Idreesy, TT; Fettinger, JC; Kurth, MJ; Lodewyk, MW; Meng, L; Tantillo, DJ; Verkman, AS; Yang, B; Yoo, CL; Yu, GJ	1
Cyr, DM; Grove, DE; Naren, AP; Ren, HY; Rosser, MF	1
Butler, JD; Kurth, MJ; Mills, AD; Verkman, AS; Yang, B; Yoo, C	1
Fettinger, JC; Knapp, JM; Kurth, MJ; Sangwung, P; Verkman, AS; Ye, L	1
Armirotti, A; Caci, E; Damonte, G; Galietta, LJ; Millo, E; Pedemonte, N; Sondo, E; Tomati, V; Zegarra-Moran, O	1
Caldwell, RA; Cyr, DM; Grove, DE; Houck, SA	1
Lamont, IL; Martin, LW; Reid, DW; Sharples, KJ	1
Caci, E; Esposito, AI; Galietta, LJ; Pedemonte, N; Pfeffer, U; Sondo, E; Tomati, V	1
Davison, HR; Derichs, N; Drake, C; Jones, EF; Kurth, MJ; Phuan, PW; Sutcliffe, J; Taylor, S; Verkman, AS; Yao, C	1
Codd, R; Cordwell, SJ; Harbour, C; Hare, NJ; Manos, J; Rose, B; Soe, CZ	1
Donald, MB; Kurth, MJ; Phuan, PW; Rodriguez, KX; Shay, H; Verkman, AS	1
Arányi, P; Bátori, S; Kapui, Z; Mikus, E; Nagy, LT; Urbán-Szabó, K; Varga, M; Vasvári-Debreczy, L	1
Haggie, PM; Song, Y; Thiagarajah, JR; Verkman, AS	1
Abraham, SN; Duncan, MJ; Li, G; Wright, JR; Zaas, DW	1
Caci, E; Du, K; Galietta, LJ; Lukacs, GL; Pedemonte, N; Verkman, AS; Zegarra-Moran, O	1
Axton, RA; Brock, DJ	1
Chan, M; Cox, AD; Darling, P; Sokol, PA	1
Castignetti, D; Haas, B; Murphy, E	1
Sokol, PA	1

Reviews

1 review(s) available for thiazoles and Cystic Fibrosis

Article	Year
An overview on chemical structures as ΔF508-CFTR correctors. European journal of medicinal chemistry, 2019, Oct-15, Volume: 180 Topics: Animals; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Mutation; Protein Folding; Pyrimidinones; Thiazoles	2019

Other Studies

34 other study(ies) available for thiazoles and Cystic Fibrosis

Article	Year
NBD2 Is Required for the Rescue of Mutant F508del CFTR by a Thiazole-Based Molecule: A Class II Corrector for the Multi-Drug Therapy of Cystic Fibrosis. Biomolecules, 2021, 09-28, Volume: 11, Issue:10 Topics: Aminopyridines; Benzodioxoles; Cell Membrane; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Gene Expression Regulation; HEK293 Cells; Humans; Mutant Proteins; Phenylalanine; Thiazoles	2021
Unravelling the Regions of Mutant F508del-CFTR More Susceptible to the Action of Four Cystic Fibrosis Correctors. International journal of molecular sciences, 2019, Nov-01, Volume: 20, Issue:21 Topics: Aminopyridines; Benzamides; Benzodioxoles; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Expression Regulation; HEK293 Cells; Humans; Indoles; Mutant Proteins; Mutation; Quinazolines; Thiazoles	2019
Synthesis and Structure-activity Relationship of Aminoarylthiazole Derivatives as Potential Potentiators of the Chloride Transport Defect in Cystic Fibrosis. Medicinal chemistry (Shariqah (United Arab Emirates)), 2021, Volume: 17, Issue:6 Topics: Biological Transport; Chemistry Techniques, Synthetic; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Evaluation, Preclinical; Structure-Activity Relationship; Thiazoles	2021
Synthesis and biological evaluation of thiazole derivatives on basic defects underlying cystic fibrosis. Bioorganic & medicinal chemistry letters, 2020, 11-01, Volume: 30, Issue:21 Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Humans; Molecular Structure; Structure-Activity Relationship; Thiazoles	2020
Evaluation of Fused Pyrrolothiazole Systems as Correctors of Mutant CFTR Protein. Molecules (Basel, Switzerland), 2021, Feb-26, Volume: 26, Issue:5 Topics: Aminoimidazole Carboxamide; Benzodioxoles; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Mutant Proteins; Mutation; Protein Folding; Thiazoles	2021
Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools. European journal of medicinal chemistry, 2018, Jan-20, Volume: 144 Topics: Aminopyridines; Benzodioxoles; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Mutation; Quantitative Structure-Activity Relationship; Thiazoles	2018
Speeding Up the Identification of Cystic Fibrosis Transmembrane Conductance Regulator-Targeted Drugs: An Approach Based on Bioinformatics Strategies and Surface Plasmon Resonance. Molecules (Basel, Switzerland), 2018, Jan-08, Volume: 23, Issue:1 Topics: Binding Sites; Computational Biology; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Evaluation, Preclinical; Humans; Molecular Dynamics Simulation; Protein Binding; Surface Plasmon Resonance; Thiazoles	2018
Correctors of the Major Cystic Fibrosis Mutant Interact through Membrane-Spanning Domains. Molecular pharmacology, 2018, Volume: 93, Issue:6 Topics: Aminopyridines; Benzamides; Benzodioxoles; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; HEK293 Cells; Humans; Mutation; Phenylalanine; Protein Structure, Tertiary; Thiazoles	2018
Bithiazole correctors rescue CFTR mutants by two different mechanisms. Biochemistry, 2013, Aug-06, Volume: 52, Issue:31 Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Models, Molecular; Molecular Structure; Mutation; Protein Binding; Protein Structure, Tertiary; Thiazoles	2013
ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles. Bioorganic & medicinal chemistry letters, 2014, Dec-15, Volume: 24, Issue:24 Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Imidazoles; Kinetics; Molecular Conformation; Oxadiazoles; Oxazoles; Protein Binding; Structure-Activity Relationship; Thermodynamics; Thiadiazoles; Thiazoles; Water	2014
The search for a common structural moiety among selected pharmacological correctors of the mutant CFTR chloride channel. Future medicinal chemistry, 2014, Volume: 6, Issue:17 Topics: Anisoles; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Gene Deletion; Humans; Models, Molecular; Molecular Conformation; Piperazines; Purines; Pyrazines; Sildenafil Citrate; Sulfonamides; Thiazoles; Vasodilator Agents	2014
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis. European journal of medicinal chemistry, 2015, Jun-24, Volume: 99 Topics: Biological Transport; Cell Line; Chemistry Techniques, Synthetic; Chlorides; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Design; Humans; Ion Channel Gating; Models, Molecular; Mutation; Protein Structure, Tertiary; Structure-Activity Relationship; Thiazoles	2015
Optimal correction of distinct CFTR folding mutants in rectal cystic fibrosis organoids. The European respiratory journal, 2016, Volume: 48, Issue:2 Topics: Aminopyridines; Benzodioxoles; Biopsy; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Genotype; Homozygote; Humans; Mutation; Organoids; Protein Folding; Protein Transport; Rectum; Thiazoles; Treatment Outcome	2016
Mechanistic Approaches to Improve Correction of the Most Common Disease-Causing Mutation in Cystic Fibrosis. PloS one, 2016, Volume: 11, Issue:5 Topics: Aminophenols; Aminopyridines; Benzamides; Benzodioxoles; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Gene Expression Regulation; Half-Life; HEK293 Cells; Humans; Mutation; Quinolones; Thiazoles	2016
Synthesis and electrochemical detection of a thiazolyl-indole natural product isolated from the nosocomial pathogen Pseudomonas aeruginosa. Analytical and bioanalytical chemistry, 2016, Volume: 408, Issue:23 Topics: Animals; Boron; Carbon; Cattle; Cystic Fibrosis; Diamond; Electrochemical Techniques; Electrodes; Feces; Humans; Indoles; Pseudomonas aeruginosa; Pseudomonas Infections; Thiazoles	2016
Potent s-cis-locked bithiazole correctors of DeltaF508 cystic fibrosis transmembrane conductance regulator cellular processing for cystic fibrosis therapy. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Humans; Models, Chemical; Molecular Structure; Protein Processing, Post-Translational; Stereoisomerism; Thiazoles	2008
Mechanisms for rescue of correctable folding defects in CFTRDelta F508. Molecular biology of the cell, 2009, Volume: 20, Issue:18 Topics: Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Endoplasmic Reticulum; Gene Knockdown Techniques; Humans; Protein Conformation; Protein Folding; Protein Stability; Protein Structure, Tertiary; RNA, Small Interfering; Suppression, Genetic; Thiazoles	2009
Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR. Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1 Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Design; Glycine; Humans; Ion Channel Gating; Mutation; Protein Folding; Small Molecule Libraries; Structure-Activity Relationship; Thiazoles	2010
Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles. Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Frameshift Mutation; Humans; Pyrazoles; Small Molecule Libraries; Static Electricity; Structure-Activity Relationship; Thiazoles	2010
Dual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations. The Journal of biological chemistry, 2011, Apr-29, Volume: 286, Issue:17 Topics: Biological Transport; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Ion Channel Gating; Mutation; Patch-Clamp Techniques; Structure-Activity Relationship; Thiazoles	2011
Increased folding and channel activity of a rare cystic fibrosis mutant with CFTR modulators. American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 301, Issue:3 Topics: Benzamides; Cresols; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; HEK293 Cells; Humans; Patch-Clamp Techniques; Protein Folding; Pyrazoles; Thiazoles	2011
Pseudomonas siderophores in the sputum of patients with cystic fibrosis. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2011, Volume: 24, Issue:6 Topics: Adult; Cystic Fibrosis; Female; Humans; Iron; Male; Oligopeptides; Phenols; Pseudomonas aeruginosa; Pseudomonas Infections; Siderophores; Sputum; Thiazoles; Young Adult	2011
Rescue of the mutant CFTR chloride channel by pharmacological correctors and low temperature analyzed by gene expression profiling. American journal of physiology. Cell physiology, 2011, Volume: 301, Issue:4 Topics: Aminacrine; Bacterial Proteins; Benzamides; Cell Line; Cell Membrane; Chlorides; Ciclopirox; Cold Temperature; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Cells; Gene Expression Profiling; Gene Expression Regulation; Humans; Hydroxamic Acids; Luminescent Proteins; Mutation; Piperazines; Protein Transport; Pyridones; Quinazolines; Thiazoles; Vorinostat	2011
Functional fluorescently labeled bithiazole ΔF508-CFTR corrector imaged in whole body slices in mice. Bioconjugate chemistry, 2011, Dec-21, Volume: 22, Issue:12 Topics: Animals; Boron Compounds; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Fluorescent Dyes; Mice; Mutation; Thiazoles; Whole Body Imaging	2011
Proteomics of Pseudomonas aeruginosa Australian epidemic strain 1 (AES-1) cultured under conditions mimicking the cystic fibrosis lung reveals increased iron acquisition via the siderophore pyochelin. Journal of proteome research, 2012, Feb-03, Volume: 11, Issue:2 Topics: Bacterial Proteins; Bacteriological Techniques; Culture Media; Cystic Fibrosis; Electrophoresis, Gel, Two-Dimensional; Host-Pathogen Interactions; Humans; Iron; Metabolic Networks and Pathways; Phenols; Proteome; Proteomics; Pseudomonas aeruginosa; Pyocyanine; Sputum; Tandem Mass Spectrometry; Thiazoles	2012
Click-based synthesis of triazolobithiazole ΔF508-CFTR correctors for cystic fibrosis. Bioorganic & medicinal chemistry, 2012, Sep-01, Volume: 20, Issue:17 Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Dose-Response Relationship, Drug; Molecular Structure; Structure-Activity Relationship; Thiazoles; Triazoles	2012
A novel orally active inhibitor of HLE. European journal of medicinal chemistry, 2003, Volume: 38, Issue:4 Topics: Administration, Oral; Animals; Asthma; Cyclic S-Oxides; Cystic Fibrosis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hemorrhage; Humans; Inflammation; Leukocyte Elastase; Lung Diseases, Obstructive; Mice; Models, Chemical; Pulmonary Emphysema; Thiazoles	2003
A small molecule CFTR inhibitor produces cystic fibrosis-like submucosal gland fluid secretions in normal airways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2004, Volume: 18, Issue:7 Topics: Animals; Benzoates; Body Fluids; Bronchi; Cells, Cultured; Chlorides; Cholinergic Agents; Colforsin; Cyclic AMP; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Exocrine Glands; Humans; Hydrogen-Ion Concentration; Pilocarpine; Second Messenger Systems; Sodium; Swine; Thapsigargin; Thiazoles; Thiazolidines; Viscosity	2004
Pseudomonas invasion of type I pneumocytes is dependent on the expression and phosphorylation of caveolin-2. The Journal of biological chemistry, 2005, Feb-11, Volume: 280, Issue:6 Topics: Animals; Caveolin 1; Caveolin 2; Caveolins; Cell Adhesion; Cell Line; Cells, Cultured; Coloring Agents; Cystic Fibrosis; Epithelial Cells; Immunoprecipitation; Lipid Metabolism; Lipids; Lung; Membrane Microdomains; Mice; Microscopy, Confocal; Microscopy, Electron; Phosphorylation; Pseudomonas; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; RNA Interference; Tetrazolium Salts; Thiazoles; Tyrosine	2005
Small-molecule correctors of defective DeltaF508-CFTR cellular processing identified by high-throughput screening. The Journal of clinical investigation, 2005, Volume: 115, Issue:9 Topics: Animals; Cells, Cultured; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Design; Enzyme Inhibitors; Epithelial Cells; Genistein; Humans; Iodides; Luminescent Proteins; Molecular Structure; Mutation; Pyrimidinones; Respiratory Mucosa; Thiazoles	2005
Use of stable dye-DNA intercalating complexes to detect cystic fibrosis mutations. Molecular and cellular probes, 1994, Volume: 8, Issue:3 Topics: Alleles; Base Sequence; Cystic Fibrosis; DNA; Fluorescence; Heterozygote; Humans; Mass Screening; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Protein Binding; Quinolinium Compounds; Thiazoles	1994
Siderophore production by cystic fibrosis isolates of Burkholderia cepacia. Infection and immunity, 1998, Volume: 66, Issue:2 Topics: Burkholderia cepacia; Cystic Fibrosis; Humans; Phenols; Pyridones; Random Amplified Polymorphic DNA Technique; Salicylates; Salicylic Acid; Siderophores; Thiazoles	1998
Siderophore synthesis by mucoid Pseudomonas aeruginosa strains isolated from cystic fibrosis patients. Canadian journal of microbiology, 1991, Volume: 37, Issue:8 Topics: Cystic Fibrosis; Iron Chelating Agents; Oligopeptides; Phenols; Pigments, Biological; Pseudomonas aeruginosa; Pseudomonas Infections; Siderophores; Thiazoles	1991
Production and utilization of pyochelin by clinical isolates of Pseudomonas cepacia. Journal of clinical microbiology, 1986, Volume: 23, Issue:3 Topics: Cystic Fibrosis; Humans; Iron Chelating Agents; Phenols; Pseudomonas; Pseudomonas Infections; Siderophores; Thiazoles; Transferrin	1986