thiazoles has been researched along with Colorectal Neoplasms in 85 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 10 (11.76) | 18.2507 |
2000's | 17 (20.00) | 29.6817 |
2010's | 44 (51.76) | 24.3611 |
2020's | 14 (16.47) | 2.80 |
Authors | Studies |
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Altaf, R; Aun Muhammad, S; Faheem, M; Ilyas, U; Nadeem, H; Naz, S; Qadir, MI; Uz Zaman, S | 1 |
Andersson, C; Blom, K; Brechot, C; Ek, F; Fryknäs, M; Jarvius, M; Larsson, R; Nygren, P; Rudfeldt, J; Selvin, T; Senkowski, W | 1 |
Hemmati-Dinarvand, M; Kheirandish, S; Khodadadian, A; Mostafazadeh, M; Seghatoleslam, A | 1 |
Cui, M; Lin, Z; Wang, X; Xu, M; Zhang, Y | 1 |
Cheng, M; Li, R; Wang, H; Wang, J | 1 |
Betzler, VM; Bode, K; Brunner, T; Delgado, ME; Delp, J; Dietrich, L; Leist, M; Mayer, TU; Ripani, P; von Scheven, G; Yan, N | 1 |
Ahmad, Z; Al-Qawasmeh, RA; Al-Tel, TH; Hersi, F; Jaber, AM; Omar, HA; Zaher, DM | 1 |
Alazragi, R; El-Sherbeeny, NA; Elaidy, SM; Helmi, N; Salem, N; Tantawy, MA | 1 |
Adachi, T; Azuma, T; Eguchi, S; Enjoji, A; Enjoji, T; Fujioka, H; Fukui, S; Haraguchi, M; Hashimoto, T; Hayashida, N; Hidaka, M; Ikebe, A; Inoue, Y; Ito, S; Kamohara, Y; Kanetaka, K; Kawakami, S; Kitajima, T; Kobayashi, K; Kosaka, T; Kuba, S; Kuroki, T; Matsuo, M; Mine, Y; Morita, M; Moriuchi, H; Natsuda, K; Okada, K; Okada, S; Ono, S; Sakimura, C; Soyama, A; Suto, R; Takatsuki, M; Taniguchi, K; Tetsuo, H; Torashima, Y; Yamaguchi, I; Yamaguchi, S; Yamanouchi, K | 1 |
Bernards, R; Boelens, MC; Huijberts, SCFA; Opdam, FL | 1 |
Bosco, B; Calheiros, J; Carvalho, ATP; Chlapek, P; Domingues, L; Fabian, P; Gomes, C; Inga, A; Monteiro, FA; Nunes, C; Piazza, S; Pinho E Melo, TMVD; Raimundo, L; Rajado, AT; Ramos, H; Reis, F; Reis, S; Saraiva, L; Silva, J; Soares, MIL; Veselska, R; Vlcek, P | 1 |
Ahmad, R; Al Madhoun, A; Al Tarrah, M; Al-Ali, W; Al-Mulla, F; Al-Rashed, F; Bitar, MS; Haddad, D; Jacob, S; Miranda, L; Nizam, R; Sindhu, S | 1 |
Ahn, J; Hwang, SG; Kim, HJ; Kim, J; Kim, JS; Nam, KY; Ryu, H; Song, JY | 1 |
Avsar, E; Bendell, JC; Chatterjee, A; Delord, JP; Demuth, T; Elez, E; Eskens, FALM; Faris, JE; Jaeger, S; Lenz, HJ; Lolkema, MP; Maharry, K; Schellens, JHM; Schuler, M; Sharma, S; Spreafico, A; Tabernero, J; Tan, E; van Geel, RMJM; Wainberg, ZA; Yaeger, R; Yamada, Y; Yoshino, T | 1 |
Ancukiewicz, K; Białowąs, W; Froelich, A; Gadziński, P; Kapela, M; Milanowski, B; Osmałek, T; Szybowicz, M | 1 |
Alipour, B; Faghfoori, Z; Mousavi Jam, A; Saber, A; Yari Khosroushahi, A | 1 |
Ding, S; Huang, H; Jiang, Y; Luo, P; Qing, B; Tang, R; Tang, Z; Zhang, S | 1 |
Li, G; Liao, W; Lv, N; Wan, H; Wang, C; Wu, Q; You, Y | 1 |
Brzozowski, T; Korbut, E; Ptak-Belowska, A | 1 |
Hou, Y; Jin, J; Liu, Q; Shi, J; Zhou, D | 1 |
Eguchi, T; Fukuchi, T; Kitamura, T; Kumagai, H; Matsuura, M; Mohri, K; Nakai, K; Nakase, H; Pham, W; Sakuma, S; Tobita, E; Tomono, T; Ukawa, M; Yamada, K; Yoshino, T; Yoshizaki, T | 1 |
Chang, H; Chen, H; Chen, Q; Huang, Y; Li, L; Li, P; Lu, M; Yu, Y | 1 |
DuBois, RN; Fu, L; Wang, D; Wei, J; Xiong, Y | 1 |
Arrowood, C; Blobe, GC; Brady, JC; Cohn, A; Haley, S; Hsu, SD; Hurwitz, HI; McCall, S; Meadows, KL; Morse, MA; Nixon, AB; Pang, H; Rushing, C; Starodub, A; Strickler, JH; Uronis, HE; Zafar, SY | 1 |
Coffey, RJ; Hanks, SK; Liu, H; Luo, W; Manning, HC; McDonald, WH; McKinley, ET; Zhao, P | 1 |
Arrowsmith, CH; Baiazitov, R; Cao, L; Davis, T; Dick, JE; Du, W; Frelin, C; Gallinger, S; Gibson, L; Iscove, NN; Kreso, A; Leung, C; Lima-Fernandes, E; Moon, YC; O'Brien, CA; Pedley, NM; Sydorenko, N; Szentgyorgyi, E; van Galen, P; Wang, Y | 1 |
Leake, I | 1 |
Wicha, MS | 1 |
Crunkhorn, S | 1 |
Brockmann, A; Brunner, T; Marx, A; May, S; Stemmer, K; Strittmatter, T | 1 |
Ma, J; Wang, KY; Xue, JS; Yu, MJ; Zhang, FX; Zhao, JS | 1 |
Aleksic, T; Esashi, F; Gao, S; Lodhia, KA; Macaulay, VM | 1 |
Gore, JC; Hiwatari, K; Ikejima, T; Kitamura, T; Koike, S; Kumagai, H; McClure, R; Mohri, K; Pham, W; Sakuma, S; Shimosato, M; Tobita, E | 1 |
Fryknäs, M; Gustafsson, M; Höglund, U; Isacson, R; Larsson, R; Linder, S; Nygren, P; Olofsson, MH; Senkowski, W; Zhang, X | 1 |
Bluwstein, A; Brockmann, A; Brunner, T; Kögel, A; Marx, A; May, S; Tschan, MP | 1 |
Guo, H; He, WT; Jiang, FC; Li, MQ; Liu, JH; Xie, L; Xing, S; Zhang, LM; Zhang, X; Zhou, P | 1 |
Hu, Y; Li, H; Peng, L; Xu, S; Yang, G; Zhao, Y | 1 |
Aarts, M; Ashworth, A; Bardelli, A; Brough, R; Campbell, J; Costa-Cabral, S; Konde, A; Lord, CJ; Marinari, E; Riffell, J; Torrance, C | 1 |
Carneiro, F; Carneiro, P; Fernandes, MS; Melo, S; Seruca, R; Velho, S | 1 |
Hiwatari, K; Hoffman, RM; Kataoka, M; Kimura, R; Ma, H; Masaoka, Y; Sakuma, S; Shoji, Y; Tachikawa, H; Tang, L; Yamashita, S; Yang, Z; Yano, T | 1 |
Liu, XY; Qian, QJ; Wang, YG; Yang, M; Yu, DB; Zheng, S; Zhong, SY | 1 |
Baron, DM; Hudec, X; Kaindl, U; Koneczny, I; König, JS; Marian, B; Röhrl, C | 1 |
Dienes, HP; Kasper, HU; Kern, M; Konze, E; Schirmacher, P; Stippel, DL | 1 |
Abrantes, AM; Beja, AM; Botelho, MF; Brito, AF; Laranjo, M; Paixão, JA; Pinho E Melo, TM; Silva, MR; Soares, MI | 1 |
Armstrong, EA; Campbell, DA; Dunn, EF; Hintz, KA; Iida, M; Li, C; Myers, RA; Wheeler, DL | 1 |
Amin, AF; Patel, MM | 1 |
Gore, JC; Higashino, H; Hiwatari, K; Kataoka, M; Kimura, R; Kumagai, H; Masaoka, Y; Nakamura, K; Pham, W; Sakuma, S; Tachikawa, H; Yamashita, S; Yano, T | 1 |
Baker, AM; Bird, D; Cox, TR; Erler, JT; Lang, G; Murray, GI; Southall, SM; Sun, XF; Wilson, JR | 1 |
Kindler, HL; Knost, JA; Modi, S; Polite, BN; Sharma, MR; Sleckman, BG; Stadler, WM; Taber, D; Vokes, EE; Wallace, JA; Wroblewski, K | 1 |
Hiwatari, K; Hoffman, RM; Pham, W; Sakuma, S; Yamashita, S | 1 |
DuBois, RN; Guo, L; Ning, W; Wang, D; Xie, D | 1 |
Bradshaw, TD; Choo, HL; Leong, CO; Muruhadas, A; Randhawa, N; Stevens, MF; Tan, BS; Tiong, KH | 1 |
Bugyik, E; Dezso, K; Döme, B; Klepetko, W; László, V; Nagy, P; Paku, S; Reiniger, L; Tímár, J; Tóvári, J | 1 |
Abdul-Razzak, KK; Aldaher, AN; Alkofahi, AS; Alsarhan, AM; Mhaidat, NM; Thorne, RF | 1 |
Brockmann, A; Brunner, T; Corazza, N; Hemphill, A; Mueller, J; Nachbur, U; Renzulli, P; Sidler, D | 1 |
Beard, L; Carlin, C; Guo, A; Markowitz, SD; Polakiewicz, RD; Possemato, A; Wang, C; Wang, Z; Zhang, P | 1 |
Chaiyasut, C; Rattanachitthawat, S; Reungpatthanaphong, S; Suwannalert, P; Tammasakchai, A | 1 |
Gore, JC; Hiwatari, K; Kataoka, M; Kimura, R; Kumagai, H; Liu, EH; McBride, J; Nakamura, K; Pham, W; Sakuma, S; Tachikawa, H; Wilson, KJ | 1 |
Cushman, I; Hurwitz, HI; Jia, J; Liu, Y; Marshall, DJ; Nixon, AB; Starodub, A | 1 |
Baek, SJ; Eling, TE; Hsi, LC; Wilson, LC | 1 |
Emura, T; Fukushima, M; Kitazato, K; Murakami, Y; Nakagawa, F | 1 |
Jin, GZ; Komada, F; Koyanagi, J; Miura, Y; Quan, HJ; Saito, S; Takeuchi, K | 1 |
Baek, SJ; Eling, TE; Lee, SH; Yamaguchi, K | 1 |
Fu, T; He, YH; He, YJ; Liu, BH; Qiao, ZY; Xiang, DB | 1 |
Martin, SG; Mukherjee, A | 1 |
Cheung, M; Fukuyama, T; Han, FS; Osajima, H; Tokuyama, H | 1 |
Gallick, GE; Herynk, MH; Parikh, NU; Zhang, J | 1 |
Enomoto, M; Gonda, T; Higuchi, T; Iwase, N; Kobayashi, H; Sugihara, K; Uetake, H | 1 |
Chang, TT; Chen, CH; Hung, RP; Lin, ML; Lu, FJ; Ong, PL; Weng, BC | 1 |
Darro, F; Etievant, C; Kiss, R; Kruczynski, A; Martinez, J; Pasteels, JL | 1 |
Eliason, JF; Kaufmann, F; Tanaka, T; Tsukaguchi, T | 1 |
Donnelly, MT; Hawkey, CJ | 1 |
Seed, B | 1 |
Auwerx, J; Briggs, M; Chen, I; Desreumaux, P; Fruchart, JC; Geboes, K; Heyman, R; Lefebvre, AM; Najib, J | 1 |
Brockman, JA; Dubois, RN; Gupta, RA | 1 |
DuBois, RN; Goldman, AP; Lamps, LW; Morrow, JD; Pairet, M; Sheng, H; Williams, CS; Williams, VP | 1 |
Aaltonen, LA; de la Chapelle, A; Eng, C; Kum, JB; Mueller, E; Sarraf, P; Smith, WM; Spiegelman, BM; Wright, HM | 1 |
Fujii, M; Imai, S; Mochizuki, F | 1 |
Hoffman, RM | 1 |
Choi, YH; Kang, CD; Kang, HS; Kang, KI; Kim, DK; Oh, EJ; Park, JH; Yoo, MA | 1 |
Baek, SJ; Eling, TE; Hsi, LC; Ikawa, H; Kameda, H; Kamitani, H; Nixon, JB | 1 |
Bottley, G; Gough, M; Melcher, A; Todryk, S; Vile, R | 1 |
Ahn, Y; Choi, KY; Kim, HI; Kim, JA; Oh, JW; Oh, SY; Park, KS | 1 |
Berger, MR; Galeano, A; Keppler, BK | 1 |
2 review(s) available for thiazoles and Colorectal Neoplasms
Article | Year |
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Lectin-immobilized fluorescent nanospheres for targeting to colorectal cancer from a physicochemical perspective.
Topics: Acetamides; Animals; Colonoscopy; Colorectal Neoplasms; Coumarins; Drug Delivery Systems; Fluorescent Dyes; Humans; Nanospheres; Peanut Agglutinin; Polystyrenes; Polyvinyls; Thiazoles | 2011 |
Review article: COX-II inhibitors--a new generation of safer NSAIDs?
Topics: Anti-Inflammatory Agents, Non-Steroidal; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Eicosanoids; Humans; Isoenzymes; Meloxicam; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Thiazines; Thiazoles | 1997 |
4 trial(s) available for thiazoles and Colorectal Neoplasms
Article | Year |
---|---|
S-1 and CPT-11 Plus Ramucirumab (IRIS+Rmab) as Second-Line Chemotherapy for Patients with Oxaliplatin-Refractory Metastatic Colorectal Cancer (mCRC): A Multicenter Phase II Study in Japan (N-DOCC-F-C-1701).
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Colorectal Neoplasms; Drug Resistance, Neoplasm; Humans; Irinotecan; Oxaliplatin; Quality of Life; Ramucirumab; Thiazoles | 2020 |
A Phase Ib Dose-Escalation Study of Encorafenib and Cetuximab with or without Alpelisib in Metastatic
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbamates; Cetuximab; Colorectal Neoplasms; Disease-Free Survival; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Mutation; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Sulfonamides; Thiazoles | 2017 |
Phase I study of dasatinib in combination with capecitabine, oxaliplatin and bevacizumab followed by an expanded cohort in previously untreated metastatic colorectal cancer.
Topics: Adult; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers, Tumor; Capecitabine; Colorectal Neoplasms; Dasatinib; Deoxycytidine; Female; Fluorouracil; Humans; Male; Maximum Tolerated Dose; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Thiazoles; Vascular Endothelial Growth Factor A | 2014 |
Dasatinib in previously treated metastatic colorectal cancer: a phase II trial of the University of Chicago Phase II Consortium.
Topics: Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Dasatinib; Female; Humans; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Thiazoles | 2012 |
79 other study(ies) available for thiazoles and Colorectal Neoplasms
Article | Year |
---|---|
Design, synthesis and biological evaluations of 2-aminothiazole scaffold containing amino acid moieties as anti-cancer agents.
Topics: Amino Acids; Animals; Antineoplastic Agents; Artemia; Colorectal Neoplasms; Drug Design; HCT116 Cells; Humans; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Protein Conformation; Thiazoles | 2021 |
Sorafenib and nitazoxanide disrupt mitochondrial function and inhibit regrowth capacity in three-dimensional models of hepatocellular and colorectal carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Colorectal Neoplasms; Humans; Liver Neoplasms; Mitochondria; Nitro Compounds; Sorafenib; Thiazoles | 2022 |
Blockage of Wnt/β-catenin Signaling Pathway in Colorectal Cancer Resistant Cells by Nitazoxanide Effects on Peptidylarginine Deiminases Expression.
Topics: Cell Line, Tumor; Colorectal Neoplasms; Drug Resistance, Neoplasm; Humans; Nitro Compounds; Oxaliplatin; Protein-Arginine Deiminases; Thiazoles; Wnt Signaling Pathway | 2022 |
Mortalin contributes to colorectal cancer by promoting proliferation and epithelial-mesenchymal transition.
Topics: beta Catenin; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; HSP70 Heat-Shock Proteins; Humans; Prognosis; Pyridines; Thiazoles; Wnt Signaling Pathway | 2020 |
PB-10, a thiazolo[4,5-d] pyrimidine derivative, targets p21-activated kinase 4 in human colorectal cancer cells.
Topics: Binding Sites; Cell Adhesion; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Drug Design; G1 Phase Cell Cycle Checkpoints; HCT116 Cells; Humans; Molecular Docking Simulation; p21-Activated Kinases; Protein Kinase Inhibitors; Pyrimidines; RNA Interference; RNA, Small Interfering; Thiazoles | 2020 |
Thiazolides promote G1 cell cycle arrest in colorectal cancer cells by targeting the mitochondrial respiratory chain.
Topics: Animals; Colorectal Neoplasms; Electron Transport; G1 Phase Cell Cycle Checkpoints; Humans; Mice; Mitochondrial Membranes; Thiazoles | 2020 |
Design and synthesis of new energy restriction mimetic agents: Potent anti-tumor activities of hybrid motifs of aminothiazoles and coumarins.
Topics: Antineoplastic Agents; Cell Cycle Checkpoints; Cell Proliferation; Cisplatin; Colorectal Neoplasms; Coumarins; Drug Design; Drug Screening Assays, Antitumor; Energy Metabolism; G1 Phase; Glucose; HCT116 Cells; HT29 Cells; Humans; Inhibitory Concentration 50; Reactive Oxygen Species; Thiazoles | 2020 |
Synthetic antiprotozoal thiazolide drug induced apoptosis in colorectal cancer cells: implications of IL-6/JAK2/STAT3 and p53/caspases-dependent signaling pathways based on molecular docking and in vitro study.
Topics: Antineoplastic Agents; Antiprotozoal Agents; Apoptosis; Caspases; Cell Cycle; Cell Survival; Colorectal Neoplasms; Cytochromes c; Fluorouracil; HCT116 Cells; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Inhibitory Concentration 50; Interleukin-6; Janus Kinase 2; Molecular Docking Simulation; Nitro Compounds; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; STAT3 Transcription Factor; Thiazoles; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A | 2020 |
Mutational profiles associated with resistance in patients with BRAFV600E mutant colorectal cancer treated with cetuximab and encorafenib +/- binimetinib or alpelisib.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Biomarkers, Tumor; Carbamates; Cetuximab; Cohort Studies; Colorectal Neoplasms; DNA Mutational Analysis; Drug Resistance, Neoplasm; Female; Humans; Male; Middle Aged; Mutation; Proto-Oncogene Proteins B-raf; Retrospective Studies; Sulfonamides; Thiazoles | 2021 |
A selective p53 activator and anticancer agent to improve colorectal cancer therapy.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cisplatin; Colorectal Neoplasms; Doxorubicin; Drug Discovery; Drug Synergism; Female; Fluorouracil; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Mice; Mice, Nude; Protein Binding; Pyrroles; Thiazoles; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2021 |
Microarray analysis reveals ONC201 mediated differential mechanisms of CHOP gene regulation in metastatic and nonmetastatic colorectal cancer cells.
Topics: Alternative Splicing; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colorectal Neoplasms; Computational Biology; Gene Expression Regulation, Neoplastic; Humans; Imidazoles; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Pyridines; Pyrimidines; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Thiazoles; Transcription Factor CHOP; Tumor Microenvironment; Up-Regulation | 2021 |
Discovery of a Novel Triazolopyridine Derivative as a Tankyrase Inhibitor.
Topics: Antineoplastic Agents; Cell Line, Tumor; Colorectal Neoplasms; Drug Discovery; Enzyme Inhibitors; Humans; Neoplasm Proteins; Pyridines; Tankyrases; Thiazoles | 2021 |
Design and characteristics of gellan gum beads for modified release of meloxicam.
Topics: Calcium Chloride; Chemistry, Pharmaceutical; Colorectal Neoplasms; Drug Carriers; Gels; Meloxicam; Polysaccharides, Bacterial; Thiazines; Thiazoles | 2017 |
Secretion metabolites of probiotic yeast, Pichia kudriavzevii AS-12, induces apoptosis pathways in human colorectal cancer cell lines.
Topics: Apoptosis; bcl-2-Associated X Protein; bcl-Associated Death Protein; Caco-2 Cells; Caspase 3; Caspase 8; Caspase 9; Cell Proliferation; Colorectal Neoplasms; Fluorouracil; HT29 Cells; Humans; Indoles; Pichia; Probiotics; Tetrazoles; Tetrazolium Salts; Thiazoles | 2017 |
IL-8 Is Involved in Estrogen-Related Receptor α-Regulated Proliferation and Migration of Colorectal Cancer Cells.
Topics: Carcinoma; Cell Movement; Cell Proliferation; Colorectal Neoplasms; ERRalpha Estrogen-Related Receptor; HCT116 Cells; HT29 Cells; Humans; Interleukin-8; MAP Kinase Signaling System; Nitriles; Receptors, Estrogen; STAT3 Transcription Factor; Thiazoles | 2017 |
Antitumor activity of Notch‑1 inhibition in human colorectal carcinoma cells.
Topics: Apoptosis; Biomarkers, Tumor; Cell Cycle; Cell Proliferation; Colorectal Neoplasms; Diamines; Gene Expression Regulation, Neoplastic; Humans; Jagged-1 Protein; Prognosis; Receptor, Notch1; Signal Transduction; Thiazoles; Tumor Cells, Cultured | 2018 |
Inhibitory effect of selenomethionine on carcinogenesis in the model of human colorectal cancer in vitro and its link to the Wnt/β-catenin pathway.
Topics: Apoptosis; bcl-2-Associated X Protein; beta Catenin; Blotting, Western; Carcinogenesis; Cell Proliferation; Colorectal Neoplasms; Gene Expression Regulation, Neoplastic; Genes, myc; Glycogen Synthase Kinase 3 beta; HT29 Cells; Humans; Models, Biological; Phosphorylation; Real-Time Polymerase Chain Reaction; RNA, Messenger; Selenomethionine; Tetrazolium Salts; Thiazoles; Wnt Signaling Pathway | 2018 |
PPARδ agonist enhances colitis-associated colorectal cancer.
Topics: Animals; Carcinogenesis; Cell Line, Tumor; Colitis; Colorectal Neoplasms; Humans; Male; Mice; Mice, Inbred C57BL; PPAR delta; Thiazoles | 2019 |
Tumor recognition of peanut agglutinin-immobilized fluorescent nanospheres in biopsied human tissues.
Topics: Animals; Colon; Colorectal Neoplasms; Coumarins; Female; Fluorescent Dyes; HT29 Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Nanospheres; Peanut Agglutinin; Thiazoles | 2019 |
RKI-1447 suppresses colorectal carcinoma cell growth via disrupting cellular bioenergetics and mitochondrial dynamics.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Endoplasmic Reticulum Stress; Energy Metabolism; Glycolysis; HCT116 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mitochondria; Mitochondrial Dynamics; Neoplasm Invasiveness; Reactive Oxygen Species; rho-Associated Kinases; Signal Transduction; Thiazoles; Transcription Factor CHOP; Urea; Xenograft Model Antitumor Assays | 2020 |
PPARδ Mediates the Effect of Dietary Fat in Promoting Colorectal Cancer Metastasis.
Topics: Animals; Colorectal Neoplasms; Diet, High-Fat; Dietary Fats; HCT116 Cells; Humans; Liver Neoplasms, Experimental; Male; Mice, Inbred NOD; Mice, Mutant Strains; Nanog Homeobox Protein; Neoplastic Stem Cells; PPAR delta; Promoter Regions, Genetic; Thiazoles; Xenograft Model Antitumor Assays | 2019 |
Global phosphotyrosine proteomics identifies PKCδ as a marker of responsiveness to Src inhibition in colorectal cancer.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Biomarkers, Tumor; Caco-2 Cells; Cell Adhesion Molecules; Cell Line, Tumor; Colorectal Neoplasms; Dasatinib; HCT116 Cells; Humans; Mice; Mice, Nude; Neoplasm Proteins; Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; Phosphoric Monoester Hydrolases; Phosphotyrosine; Protein Kinase C-delta; Protein Kinase Inhibitors; Proteome; Proteomics; Pyrimidines; Receptor-Like Protein Tyrosine Phosphatases, Class 5; src-Family Kinases; Thiazoles | 2013 |
Self-renewal as a therapeutic target in human colorectal cancer.
Topics: Animals; Blotting, Western; Bromodeoxyuridine; Cell Line, Tumor; Colorectal Neoplasms; Flow Cytometry; Genetic Vectors; Heterocyclic Compounds, 2-Ring; Humans; Luciferases; Mice, Inbred NOD; Mice, SCID; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Polycomb Repressive Complex 1; RNA Interference; RNA, Small Interfering; Thiazoles | 2014 |
Colorectal cancer: targeting self-renewal of cancer stem cells in colorectal cancer-a future treatment option?
Topics: Animals; Colorectal Neoplasms; Heterocyclic Compounds, 2-Ring; Humans; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Polycomb Repressive Complex 1; Thiazoles | 2014 |
Targeting self-renewal, an Achilles' heel of cancer stem cells.
Topics: Animals; Colorectal Neoplasms; Heterocyclic Compounds, 2-Ring; Humans; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Polycomb Repressive Complex 1; Thiazoles | 2014 |
Anticancer drugs: Curbing self-renewal of cancer-initiating cells.
Topics: Animals; Colorectal Neoplasms; Heterocyclic Compounds, 2-Ring; Humans; Neoplasm Recurrence, Local; Neoplastic Stem Cells; Polycomb Repressive Complex 1; Thiazoles | 2014 |
Structure-function relationship of thiazolide-induced apoptosis in colorectal tumor cells.
Topics: Antineoplastic Agents; Antiparasitic Agents; Apoptosis; Benzamides; Caco-2 Cells; Caspases; Colorectal Neoplasms; Glutathione S-Transferase pi; Halogenation; Humans; Models, Molecular; Nitro Compounds; Structure-Activity Relationship; Thiazoles | 2014 |
MicroRNA-378 inhibits cell growth and enhances L-OHP-induced apoptosis in human colorectal cancer.
Topics: Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Colorectal Neoplasms; Computational Biology; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Kaplan-Meier Estimate; Luciferases; MicroRNAs; Organoplatinum Compounds; Oxaliplatin; Real-Time Polymerase Chain Reaction; RNA Splicing Factors; RNA-Binding Proteins; Tetrazolium Salts; Thiazoles | 2014 |
Suppression of homologous recombination sensitizes human tumor cells to IGF-1R inhibition.
Topics: Blotting, Western; Boron Compounds; BRCA1 Protein; BRCA2 Protein; CDC2 Protein Kinase; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Breaks, Double-Stranded; DNA Repair; Histones; Homologous Recombination; Humans; Isoxazoles; Male; Microscopy, Fluorescence; Phosphorylation; Prostatic Neoplasms; PTEN Phosphohydrolase; Pyrimidines; Quinolines; Rad51 Recombinase; Receptor, IGF Type 1; RNA Interference; Thiazoles | 2015 |
Drug combo beneficial in colorectal cancer.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Carbamates; Cetuximab; Colorectal Neoplasms; Humans; Sulfonamides; Thiazoles | 2015 |
Toxicity studies of coumarin 6-encapsulated polystyrene nanospheres conjugated with peanut agglutinin and poly(N-vinylacetamide) as a colonoscopic imaging agent in rats.
Topics: Acetamides; Animals; Body Weight; Caco-2 Cells; CHO Cells; Colon; Colonoscopy; Colorectal Neoplasms; Coumarins; Cricetulus; Drinking; Eating; Fluorescent Dyes; Humans; Male; Nanospheres; Peanut Agglutinin; Polystyrenes; Polyvinyls; Rats; Rectum; Thiazoles | 2015 |
Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer.
Topics: Administration, Oral; Animals; Anthelmintics; Antineoplastic Agents; Cell Culture Techniques; Cell Hypoxia; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Repositioning; Drug Screening Assays, Antitumor; Female; Green Fluorescent Proteins; HCT116 Cells; HT29 Cells; Humans; Mice, Inbred Strains; Mice, Nude; Microscopy, Fluorescence; Nitro Compounds; Oxidative Phosphorylation; Signal Transduction; Spheroids, Cellular; Thiazoles; Xenograft Model Antitumor Assays | 2015 |
Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; bcl-X Protein; Caco-2 Cells; Cell Line; Cisplatin; Colorectal Neoplasms; Drug Resistance, Neoplasm; Enzyme Activation; Glutathione S-Transferase pi; HEK293 Cells; Humans; JNK Mitogen-Activated Protein Kinases; Membrane Proteins; Mitochondria; Myeloid Cell Leukemia Sequence 1 Protein; p38 Mitogen-Activated Protein Kinases; Protein Binding; Proto-Oncogene Proteins; Reactive Oxygen Species; RNA Interference; RNA, Small Interfering; Thiazoles | 2015 |
Targeting of MyD88 Homodimerization by Novel Synthetic Inhibitor TJ-M2010-5 in Preventing Colitis-Associated Colorectal Cancer.
Topics: Animals; Antineoplastic Agents; Chemokines; Colitis; Colorectal Neoplasms; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Molecular Targeted Therapy; Myeloid Differentiation Factor 88; Piperazines; Protein Multimerization; Real-Time Polymerase Chain Reaction; Signal Transduction; Thiazoles | 2016 |
The hypoxia-mimetic agent CoCl₂ induces chemotherapy resistance in LOVO colorectal cancer cells.
Topics: bcl-2-Associated X Protein; bcl-Associated Death Protein; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Cobalt; Colorectal Neoplasms; Down-Regulation; Doxorubicin; Drug Resistance, Neoplasm; Fluorouracil; Humans; Real-Time Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles | 2016 |
CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours.
Topics: Animals; Antineoplastic Agents; CDC2 Protein Kinase; Cell Line, Tumor; Colorectal Neoplasms; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Female; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation, Neoplastic; Genes, Lethal; High-Throughput Screening Assays; Humans; Imidazoles; Mice; Mice, Inbred BALB C; Mice, Nude; Mutation; Pancreatic Neoplasms; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Pyrimidines; Quinolines; RNA, Small Interfering; Signal Transduction; Survival Analysis; Thiazoles; Xenograft Model Antitumor Assays | 2016 |
Specific inhibition of p110α subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers.
Topics: Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Colorectal Neoplasms; HCT116 Cells; Humans; Mutation; Proto-Oncogene Proteins p21(ras); RNA Interference; Signal Transduction; Thiazoles | 2016 |
In vitro/in vivo biorecognition of lectin-immobilized fluorescent nanospheres for human colorectal cancer cells.
Topics: Acetamides; Animals; Antigens, Tumor-Associated, Carbohydrate; Cell Line; Colorectal Neoplasms; Coumarins; Diagnostic Imaging; Fluorescent Dyes; Humans; Mice; Mice, Nude; Models, Animal; Nanospheres; Peanut Agglutinin; Polyvinyls; Thiazoles | 2009 |
Potent antitumor activity of double-regulated oncolytic adenovirus-mediated ST13 for colorectal cancer.
Topics: Adenoviridae; Animals; Apoptosis; Benzimidazoles; Cell Death; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Coloring Agents; Cytopathogenic Effect, Viral; Eosine Yellowish-(YS); Female; Fluorescent Dyes; Gene Expression; Genetic Therapy; Genetic Vectors; Gentian Violet; HCT116 Cells; Hematoxylin; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Nude; Oncolytic Virotherapy; Tetrazolium Salts; Thiazoles; Xenograft Model Antitumor Assays | 2009 |
Peroxisome-proliferator-activated receptors γ and β/δ mediate vascular endothelial growth factor production in colorectal tumor cells.
Topics: Cell Line, Tumor; Colorectal Neoplasms; Cyclooxygenase 2; Humans; Peroxisome Proliferator-Activated Receptors; PPAR delta; PPAR gamma; PPAR-beta; RNA, Messenger; Thiazoles; Thiazolidinediones; Vascular Endothelial Growth Factor A | 2011 |
COX-2 expression and effects of COX-2 inhibition in colorectal carcinomas and their liver metastases.
Topics: Adenoma; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Female; Humans; Liver Neoplasms; Male; Meloxicam; Middle Aged; Thiazines; Thiazoles; Tissue Array Analysis | 2010 |
Chiral 6-hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: novel antitumor DNA monoalkylating agents.
Topics: Adenocarcinoma; Antineoplastic Agents, Alkylating; Breast Neoplasms; Cell Line, Tumor; Colorectal Neoplasms; DNA; Drug Screening Assays, Antitumor; Female; Humans; Melanoma; Pyrroles; Thiazoles | 2010 |
Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Cetuximab; Colorectal Neoplasms; Dasatinib; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; HCT116 Cells; Humans; Immunoblotting; Male; Mice; Mice, Nude; Mutation; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyrimidines; ras Proteins; RNA Interference; src-Family Kinases; Thiazoles; Xenograft Model Antitumor Assays | 2011 |
Formulation and development of release modulated colon targeted system of meloxicam for potential application in the prophylaxis of colorectal cancer.
Topics: Animals; Cellulose; Chemistry, Pharmaceutical; Colon; Colorectal Neoplasms; Cyclooxygenase 2 Inhibitors; Delayed-Action Preparations; Drug Delivery Systems; Drug Stability; Hydrogen-Ion Concentration; Meloxicam; Polyethylene Glycols; Polymethacrylic Acids; Rabbits; Solubility; Tablets; Thiazines; Thiazoles | 2011 |
A potential of peanut agglutinin-immobilized fluorescent nanospheres as a safe candidate of diagnostic drugs for colonoscopy.
Topics: Animals; Caco-2 Cells; Colon; Colonoscopy; Colorectal Neoplasms; Coumarins; Early Detection of Cancer; Female; Fluorescent Dyes; Humans; Indicators and Reagents; Intestinal Mucosa; Mice; Nanospheres; Peanut Agglutinin; Thiazoles | 2011 |
The role of lysyl oxidase in SRC-dependent proliferation and metastasis of colorectal cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Dasatinib; Disease Progression; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Genetic Vectors; Humans; Immunoblotting; Immunohistochemistry; Mice; Mice, Nude; Mutation; Phosphorylation; Protein Array Analysis; Protein Kinase Inhibitors; Protein-Lysine 6-Oxidase; Pyrimidines; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; src-Family Kinases; Thiazoles; Transfection; Up-Regulation | 2011 |
Peroxisome proliferator-activated receptor δ confers resistance to peroxisome proliferator-activated receptor γ-induced apoptosis in colorectal cancer cells.
Topics: Apoptosis; Caspase 3; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; DNA Fragmentation; Gene Expression; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Humans; Inhibitor of Apoptosis Proteins; Oxazoles; PPAR delta; PPAR gamma; Survivin; Thiazoles; Tyrosine | 2012 |
CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells.
Topics: Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Colorectal Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Induction; Female; Humans; Male; Thiazoles | 2011 |
Lack of angiogenesis in experimental brain metastases.
Topics: Angiopoietin-1; Animals; Brain Neoplasms; Breast Neoplasms; Bromodeoxyuridine; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; DNA-Binding Proteins; Electron Microscope Tomography; Female; Glial Fibrillary Acidic Protein; Humans; Keratins; Lamins; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Quinolines; Receptor, Platelet-Derived Growth Factor beta; Thiazoles; Vascular Endothelial Growth Factor A | 2011 |
Altholactone induces apoptotic cell death in human colorectal cancer cells.
Topics: Acetylcysteine; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase Inhibitors; Caspases, Initiator; Cell Death; Cell Survival; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Enzyme Activation; Fibroblasts; Furans; Goniothalamus; HCT116 Cells; HT29 Cells; Humans; Oxidative Stress; Propidium; Pyrones; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles | 2012 |
Thiazolide-induced apoptosis in colorectal cancer cells is mediated via the Jun kinase-Bim axis and reveals glutathione-S-transferase P1 as Achilles' heel.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Benzamides; Caco-2 Cells; Cell Line, Tumor; Colorectal Neoplasms; Down-Regulation; Glutathione S-Transferase pi; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Membrane Proteins; Mitochondria; Proto-Oncogene Proteins; RNA Interference; RNA, Small Interfering; Thiazoles; TNF-Related Apoptosis-Inducing Ligand | 2012 |
Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14.
Topics: Amino Acid Sequence; Animals; Cell Transformation, Neoplastic; Colorectal Neoplasms; Crk-Associated Substrate Protein; Dasatinib; Epidermal Growth Factor; Female; Gene Knock-In Techniques; HCT116 Cells; HEK293 Cells; HT29 Cells; Humans; Mice; Mice, Nude; Molecular Sequence Data; Phosphorylation; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases, Non-Receptor; Pyrimidines; Signal Transduction; Thiazoles; Transplantation, Heterologous | 2013 |
Red strain oryza sativa-unpolished thai rice prevents oxidative stress and colorectal aberrant crypt foci formation in rats.
Topics: Aberrant Crypt Foci; Animals; Antioxidants; Azoxymethane; Benzothiazoles; Biphenyl Compounds; Colorectal Neoplasms; Male; Malondialdehyde; Oryza; Oxidative Stress; Phytotherapy; Picrates; Plant Extracts; Rats; Rats, Sprague-Dawley; Sulfonic Acids; Thiazoles | 2012 |
Multifunctional nanobeacon for imaging Thomsen-Friedenreich antigen-associated colorectal cancer.
Topics: Animals; Antigens, Tumor-Associated, Carbohydrate; Blotting, Western; Case-Control Studies; Colon; Colorectal Neoplasms; Coumarins; Diagnostic Imaging; Fluorescent Dyes; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Transgenic; Nanospheres; Peanut Agglutinin; Polystyrenes; Real-Time Polymerase Chain Reaction; Rectum; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Surface Properties; Thiazoles; Tissue Distribution; Tumor Cells, Cultured | 2013 |
Dual inhibition of αV integrins and Src kinase activity as a combination therapy strategy for colorectal cancer.
Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Dasatinib; Focal Adhesion Kinase 1; Human Umbilical Vein Endothelial Cells; Humans; Integrin alphaV; Paxillin; Phosphorylation; Pyrimidines; Signal Transduction; src-Family Kinases; Thiazoles | 2013 |
Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma ) ligand, selectively induces the early growth response-1 gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity.
Topics: 3' Untranslated Regions; Antineoplastic Agents; Apoptosis; Base Sequence; Cell Division; Chromans; Colorectal Neoplasms; Dactinomycin; DNA Primers; DNA-Binding Proteins; Early Growth Response Protein 1; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Immediate-Early Proteins; K562 Cells; Plasmids; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; RNA, Messenger; RNA, Neoplasm; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Transfection; Troglitazone; Tumor Cells, Cultured; Zinc Fingers | 2003 |
A novel antimetabolite, TAS-102 retains its effect on FU-related resistant cancer cells.
Topics: Animals; Antimetabolites; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colorectal Neoplasms; Coloring Agents; Drug Combinations; Drug Resistance, Neoplasm; Fluorouracil; Globins; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Models, Chemical; Neoplasm Metastasis; Neoplasm Transplantation; Polymerase Chain Reaction; Pyrrolidines; Sensitivity and Specificity; Tetrazolium Salts; Thiazoles; Thymidine Phosphorylase; Thymine; Trifluridine; Uracil | 2004 |
4'-O-Alkyaloenin derivatives and their sulfates directed toward overcoming multidrug resistance in tumor cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Colorectal Neoplasms; Coloring Agents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Glucosides; Humans; Liver Neoplasms; Sulfates; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2005 |
A novel peroxisome proliferator-activated receptor gamma ligand, MCC-555, induces apoptosis via posttranscriptional regulation of NAG-1 in colorectal cancer cells.
Topics: 3' Untranslated Regions; Antineoplastic Agents; Apoptosis; Base Sequence; Colorectal Neoplasms; Cytokines; Gene Expression Regulation, Neoplastic; Growth Differentiation Factor 15; HCT116 Cells; Humans; Ligands; Molecular Sequence Data; PPAR gamma; RNA, Messenger; Thiazoles; Thiazolidinediones; Tumor Cells, Cultured; Up-Regulation | 2006 |
Inhibitory effect of caffeic acid phenethyl ester on the growth of SW480 colorectal tumor cells involves beta-catenin associated signaling pathway down-regulation.
Topics: Animals; Apoptosis; beta Catenin; Caffeic Acids; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Nucleus; Cell Proliferation; Colorectal Neoplasms; Dose-Response Relationship, Drug; Down-Regulation; Humans; Phenylethyl Alcohol; Signal Transduction; Tetrazolium Salts; Thiazoles | 2006 |
In vitro cytotoxicity of Phortress against colorectal cancer.
Topics: Biological Assay; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Cyclohexanes; Endothelial Cells; Fatty Acids, Unsaturated; Fibroblasts; Humans; Neovascularization, Physiologic; Paclitaxel; Prodrugs; Sesquiterpenes; Thiazoles | 2006 |
Novel structural motifs consisting of chiral thiazolines: synthesis, molecular recognition, and anticancer activity.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Survival; Colorectal Neoplasms; Humans; Macrocyclic Compounds; Male; Molecular Structure; Pancreatic Neoplasms; Prostatic Neoplasms; Thiazoles; Tumor Cells, Cultured | 2007 |
Activation of Src by c-Met overexpression mediates metastatic properties of colorectal carcinoma cells.
Topics: Autoradiography; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Genes, src; Humans; Immunohistochemistry; Immunoprecipitation; Neoplasm Metastasis; Neovascularization, Pathologic; Phosphorylation; Prognosis; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-met; Signal Transduction; Tetrazolium Salts; Thiazoles; Tumor Stem Cell Assay; Vascular Endothelial Growth Factor A | 2007 |
The effect of meloxicam, a selective COX-2 inhibitor, on the microvasculature of small metastatic liver tumors in rats.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Colorectal Neoplasms; Cyclooxygenase Inhibitors; Liver Neoplasms; Male; Meloxicam; Microcirculation; Microscopy, Electron, Scanning; Rats; Rats, Inbred F344; Thiazines; Thiazoles | 2007 |
The anticancer effect of protein-extract from Bidens alba in human colorectal carcinoma SW480 cells via the reactive oxidative species- and glutathione depletion-dependent apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Bidens; Caspases; Cell Count; Cell Cycle; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Cytochromes c; Cytosol; Flow Cytometry; Glutathione; Humans; In Situ Nick-End Labeling; Indicators and Reagents; Mitochondria; Plant Extracts; Plant Proteins; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2008 |
Characterization of the differentiation of human colorectal cancer cell lines by means of Voronoi diagrams.
Topics: Adenocarcinoma; Analog-Digital Conversion; Animals; Blood Physiological Phenomena; Cattle; Cell Death; Cell Differentiation; Cell Division; Cell Nucleus; Clone Cells; Colorectal Neoplasms; Colorimetry; Culture Media; Culture Media, Serum-Free; Humans; Image Processing, Computer-Assisted; Models, Theoretical; S Phase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1993 |
Anti-proliferative effects of the arotinoid Ro 40-8757 on human cancer cell lines in vitro.
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Division; Cell Survival; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Humans; Kinetics; Lung Neoplasms; Morpholines; Neoplasms; Receptors, Estrogen; Retinoids; Tetrazolium Salts; Thiazoles; Tretinoin; Tumor Cells, Cultured | 1993 |
PPARgamma and colorectal carcinoma: conflicts in a nuclear family.
Topics: Adenomatous Polyposis Coli; Animals; Chromans; Colorectal Neoplasms; Humans; Mice; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 1998 |
Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice.
Topics: Adenocarcinoma; Animals; beta Catenin; Chromans; Colorectal Neoplasms; Cyclooxygenase 2; Cytoskeletal Proteins; HT29 Cells; Humans; Isoenzymes; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Trans-Activators; Transcription Factors; Troglitazone | 1998 |
Activation of PPARgamma leads to inhibition of anchorage-independent growth of human colorectal cancer cells.
Topics: Cell Cycle; Cell Division; Colorectal Neoplasms; G1 Phase; Humans; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Cells, Cultured | 1998 |
Meloxicam inhibits the growth of colorectal cancer cells.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Division; Collagen; Colorectal Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Combinations; Humans; Isoenzymes; Laminin; Meloxicam; Membrane Proteins; Mice; Mice, Nude; Neoplasm Transplantation; Prostaglandin-Endoperoxide Synthases; Proteoglycans; Thiazines; Thiazoles; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
Loss-of-function mutations in PPAR gamma associated with human colon cancer.
Topics: Amino Acid Substitution; Binding Sites; Chromans; Colorectal Neoplasms; Dimerization; DNA-Binding Proteins; Exons; Genes, Tumor Suppressor; Humans; Hydroxyeicosatetraenoic Acids; Ligands; Linoleic Acids; Linoleic Acids, Conjugated; Mutation; Prostaglandin D2; Protein Binding; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Response Elements; Retinoid X Receptors; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone | 1999 |
[Comparative study of histopathological effects of preoperative chemotherapy using UFT and in vitro MTT assay of colonoscopy specimens from patients with colorectal cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Colonoscopy; Colorectal Neoplasms; Drug Administration Schedule; Drug Screening Assays, Antitumor; Fluorouracil; Humans; Tegafur; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Uracil | 1999 |
The clinical benefit of the histoculture drug response assay.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Coloring Agents; Drug Screening Assays, Antitumor; Humans; Neoplasms; Stomach Neoplasms; Survival Analysis; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2000 |
Synergistic effects of dexamethasone and genistein on the expression of Cdk inhibitor p21WAF1/CIP1 in human hepatocellular and colorectal carcinoma cells.
Topics: Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; beta-Galactosidase; Blotting, Western; Carcinoma, Hepatocellular; Cell Division; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Dexamethasone; Drug Synergism; Electrophoresis, Agar Gel; Flow Cytometry; Genistein; Humans; Liver Neoplasms; Luciferases; Promoter Regions, Genetic; RNA, Messenger; Tetrazolium Salts; Thiazoles; Transfection; Tumor Cells, Cultured | 2001 |
Effect of PPAR activators on cytokine-stimulated cyclooxygenase-2 expression in human colorectal carcinoma cells.
Topics: Adenocarcinoma; Colorectal Neoplasms; Cyclooxygenase 2; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; Isoenzymes; Ligands; Membrane Proteins; Models, Biological; Prostaglandin-Endoperoxide Synthases; Pyrimidines; Receptor Cross-Talk; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Signal Transduction; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Necrosis Factor-alpha | 2001 |
Cell death associated with genetic prodrug activation therapy of colorectal cancer.
Topics: Adenoviridae; Animals; Cell Cycle; Cell Death; Colorectal Neoplasms; Disease Models, Animal; DNA Fragmentation; Flow Cytometry; Ganciclovir; Genetic Therapy; Genetic Vectors; Humans; Mice; Neoplasm Transplantation; Phosphorylation; Prodrugs; Simplexvirus; Tetrazolium Salts; Thiazoles; Thymidine Kinase; Transduction, Genetic; Tumor Cells, Cultured | 2001 |
Troglitazone activates p21Cip/WAF1 through the ERK pathway in HCT15 human colorectal cancer cells.
Topics: Blotting, Western; Bromodeoxyuridine; Cell Division; Cell Nucleus; Chromans; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; Enzyme Inhibitors; ets-Domain Protein Elk-1; Flavonoids; HT29 Cells; Humans; Luciferases; Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins; Recombinant Fusion Proteins; Signal Transduction; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2002 |
Activity of two platinum-linked phosphonic acids against autochthonous rat colorectal cancer as well as in two human colon-cancer cell lines.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Humans; Male; Organophosphonates; Organophosphorus Compounds; Organoplatinum Compounds; Rats; Rats, Inbred Lew; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1992 |