thiazoles has been researched along with Cancer of Head in 49 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (8.16) | 18.7374 |
| 1990's | 2 (4.08) | 18.2507 |
| 2000's | 14 (28.57) | 29.6817 |
| 2010's | 25 (51.02) | 24.3611 |
| 2020's | 4 (8.16) | 2.80 |
| Authors | Studies |
|---|---|
| Barbash, Z; Bauman, JE; Cho, J; Grandis, JR; Jin, N; Johnson, DE; Jura, N; Kang, H; Keam, B; Kim, HR; Kim, MO; Krogan, NJ; Lee, MJ; Li, H; Mills, GB; Ng, PK; Swaney, DL; Tarcic, G; Torosyan, H; VanLandingham, NK; Zeng, Y | 1 |
| Sabra, MM; Sherman, EJ; Tuttle, RM; Yeh, T; Yeung, M | 1 |
| Ailles, L; Barrett, JW; Boutros, PC; Fung, K; Howlett, CJ; MacNeil, D; Meens, J; Mymryk, JS; Nichols, AC; Pinto, N; Plantinga, P; Ruicci, KM; Stecho, W; Yoo, J | 1 |
| Chen, JH; Chuang, FC; Hwang, TZ; Su, YC; Wang, CC; Yeh, SA | 1 |
| Bu, LL; Deng, WW; Kulkarni, AB; Li, YC; Liu, B; Liu, JF; Mao, L; Sun, ZJ; Wu, L; Yu, GT; Zhang, L; Zhang, WF; Zhao, ZL | 1 |
| Contreras, D; García-Escudero, R; Gutiérrez-Muñoz, C; Lorz, C; Navarro, EM; Paramio, JM; Segrelles, C | 1 |
| Barrett, JW; Fung, K; Khan, MI; MacNeil, D; Mymryk, JS; Nichols, AC; Pinto, N; Ruicci, KM; Yoo, J | 1 |
| Badarni, M; Balaban, N; Cohen, L; Dinur, AB; Elkabets, M; Grénman, R; Joshua, BZ; Prasad, M; Rotblat, B; Yegodayev, KM; Zorea, J | 1 |
| Ahn, JC; Biswas, R; Chung, PS; Lee, YK; Mondal, A | 1 |
| Hu, J; Li, C; Li, H; Li, L; Mei, X; Ren, F; Weng, Z; Wu, M; Zhang, H; Zhao, Y | 1 |
| Bai, A; Bielawska, A; Bielawski, J; Boppana, NB; Breen, P; Gudz, TI; Joseph, N; Korbelik, M; Kraveka, JM; Li, L; Pierce, JS; Rahmaniyan, M; Separovic, D; Van Buren, E | 1 |
| Bussink, J; Grénman, R; Iida, M; Kaanders, JH; Peeters, WJ; Span, PN; Stegeman, H; van der Kogel, AJ; Verheijen, MM; Wheeler, DL | 1 |
| Chen, CC; Huang, LY; Huang, WC; Lin, YC; Lin, YT; Wei, TT; Wu, MH | 1 |
| Brockhoff, G; Doescher, J; Haug, A; Mißlbeck, M; Pickhard, A; Piontek, G; Reiter, R; Rudelius, M; Schiefler, C; Schuettler, D | 1 |
| Ahn, YO; Heo, DS; Keam, B; Kim, DW; Kim, S; Kim, TM; Lee, SH | 1 |
| Baselga, J; Benzaken, AO; Bivona, TG; Brook, S; Chen, Y; Das, R; Elkabets, M; Ghossein, RA; Gurski, JM; Huang, A; Juric, D; Kerr, DA; Liang, J; Liu, M; Morse, N; Pazarentzos, E; Pelossof, RA; Rodon, J; Rosell, R; Rosen, N; Scaltriti, M; Sheng, Q; Tam, A; Teixidó, C; Wang, H; Yan, JJ | 1 |
| Brands, RC; Hartmann, S; Herbst, F; Kübler, AC; Linz, C; Müller-Richter, UDA; Seher, A | 1 |
| Bu, LL; Gutkind, JS; Huang, CF; Kulkarni, AB; Liu, B; Liu, JF; Ma, SR; Sun, ZJ; Yu, GT; Zhang, L; Zhang, WF; Zhao, ZL | 1 |
| Fukuda, S; Inamura, N; Kimura, T; Nishihara, H; Tanaka, S; Tanino, M; Tsuda, M; Wang, L; Yanagi, H | 1 |
| Baselga, J; Brook, S; Haimovitz-Friedman, A; Healey, JH; Heller, DA; Humm, JL; Mizrachi, A; Powell, SN; Rajasekhar, VK; Scaltriti, M; Shah, J; Shamay, Y; Soong, J | 1 |
| Gallick, G; Johnson, FM; Parikh, N; Saigal, B; Sen, B | 1 |
| Ding, X; Li, P; Liu, FY; Sun, CF; Zhao, ZJ; Zong, ZH | 1 |
| Gerster, K; Gilbert, R; Ito, E; Liu, FF; Ng, B; Shi, W; Waldron, J; Yue, S | 1 |
| Dunn, EF; Iida, M; Li, C; Wheeler, DL | 1 |
| Chinn, SB; Hochstim, C; Masood, R; Schorn, VJ; Sinha, UK; Zhu, S | 1 |
| Bekele, BN; Brooks, HD; Culotta, KS; El-Naggar, A; Ginsberg, LE; Glisson, BS; Johnson, FM; Papadimitrakopoulou, VA; Takebe, N; Tran, HT; Wright, J | 1 |
| Knecht, R; Kurzweg, T; Laban, S; Möckelmann, N | 1 |
| Bednash, JS; Chiosea, SI; Grandis, JR; Morariu, EM; Otte, CG; Seethala, RR; Wheeler, SE | 1 |
| Chen, CC; Chen, KF; Cheng, AL; Chuang, SH; Lin, YC; Wei, TT; Wu, MH | 1 |
| Ang, KK; Glisson, B; Johnson, FM; Milas, L; Molkentine, DP; Molkentine, JM; Raju, U; Riesterer, O; Wang, ZQ | 1 |
| Corvò, R; Rossi, L | 1 |
| Almahmeed, T; Boyle, JO; Cohen, EG; Dannenberg, AJ; Du, B; Golijanin, D; Soslow, RA; Subbaramaiah, K | 1 |
| Gooding, WE; Grandis, JR; Li, M; Lui, VW; Niwa, H; Wentzel, AL | 1 |
| Imagawa, Y; Kimura, S; Satake, K; Tsukuda, M | 1 |
| Bielawski, J; Day, TA; Hannun, YA; Jazwinski, SM; Jiang, JC; Koybasi, S; Obeid, LM; Ogretmen, B; Osta, W; Senkal, CE; Spassieva, S; Sundararaj, K | 1 |
| Bauer, JA; Bradford, CR; Carey, TE; Fisher, SG; Ji, M; Narayan, A; O'Connell, KM; Oliver, CL; Ubell, ML; Wang, S; Wolter, KG; Wu, X | 1 |
| Carey, TE; Dünne, AA; Geyer, M; Grénman, R; Mandic, R; Müller, JF; Schamberger, CJ; Werner, JA; Zhu, L | 1 |
| Donato, NJ; Johnson, FM; Saigal, B; Talpaz, M | 1 |
| Chakrabarti, R; Cohen, AN; LoTempio, MM; Ramalingam, TS; Ramamurthy, B; Srivatsan, ES; Steele, HL; Veena, MS; Wang, MB | 1 |
| Siu, LL | 1 |
| Ferris, RL; Gooding, W; Hasegawa, H; Seethala, RR; van Waes, C; Wang, J; Zhang, Q | 1 |
| Brugarolas, A; Gosalvez, M | 2 |
| Barbieri, A; Boccardo, F; Canobbio, L; Guarneri, D; Merlano, M; Rosso, R | 1 |
| Alberto, P | 1 |
| Bancroft, CC; Capo, DE; Chen, Z; Dong, G; Mukaida, N; Sunwoo, JB; Van Waes, C; Wolf, JS; Yeh, NT | 1 |
| Goberdhan, A; Hoffman, RM; Li, R; Patel, S; Pfister, D; Poluri, A; Shah, J; Shaha, AR; Sherman, E; Singh, B; Xu, L | 1 |
| Keepers, YP; Peters, GJ; Pinedo, HM; Pizao, PE; van Ark-Otte, J; Winograd, B | 1 |
| Day, R; Hata, K; Heo, DS; Herberman, RB; Park, JG; Whiteside, TL | 1 |
2 review(s) available for thiazoles and Cancer of Head
| Article | Year |
|---|---|
Current treatment options for recurrent/metastatic head and neck cancer: a post-ASCO 2011 update and review of last year's literature.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Benzodioxoles; Carcinoma, Squamous Cell; Cetuximab; Combined Modality Therapy; Dasatinib; ErbB Receptors; Fluorouracil; Gefitinib; Head and Neck Neoplasms; Humans; Indoles; Neoplasm Recurrence, Local; Palliative Care; Pyrimidines; Pyrroles; Quinazolines; Quinazolinones; Salvage Therapy; Squamous Cell Carcinoma of Head and Neck; Sunitinib; Thiazoles | 2012 |
Promising new targeted agents in head and neck cancer.
Topics: Aurora Kinases; Carcinoma, Squamous Cell; Dasatinib; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Head and Neck Neoplasms; Humans; Protein Serine-Threonine Kinases; Pyrimidines; Sirolimus; src-Family Kinases; Thiazoles | 2007 |
2 trial(s) available for thiazoles and Cancer of Head
| Article | Year |
|---|---|
Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Child; Cytokines; Dasatinib; Disease-Free Survival; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Metastasis; Protein Kinase Inhibitors; Pyrimidines; Thiazoles | 2011 |
Preliminary clinical results with norgamem (thioproline) and revercan (2-amino-2-thiazoline): the first inducers of reverse transformation.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Clinical Trials as Topic; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasms; Thiazoles; Thiazolidines; Urinary Bladder Neoplasms | 1982 |
45 other study(ies) available for thiazoles and Cancer of Head
| Article | Year |
|---|---|
Therapeutic implications of activating noncanonical PIK3CA mutations in head and neck squamous cell carcinoma.
Topics: Animals; Class I Phosphatidylinositol 3-Kinases; Head and Neck Neoplasms; Humans; Male; Mice; Middle Aged; Mutation; Protein Domains; Squamous Cell Carcinoma of Head and Neck; Thiazoles | 2021 |
Structural Doubling Time Predicts Overall Survival in Patients with Medullary Thyroid Cancer in Patients with Rapidly Progressive Metastatic Medullary Thyroid Cancer Treated with Molecular Targeted Therapies.
Topics: Adolescent; Adult; Aged; Calcitonin; Carcinoembryonic Antigen; Carcinoma, Neuroendocrine; Cell Proliferation; Disease Progression; Female; Follow-Up Studies; Head and Neck Neoplasms; Humans; Liver Neoplasms; Lung Neoplasms; Magnetic Resonance Imaging; Male; Middle Aged; Molecular Targeted Therapy; Neoplasm Metastasis; Prognosis; Retrospective Studies; Tetrazolium Salts; Thiazoles; Thyroid Neoplasms; Time Factors; Tomography, X-Ray Computed; Treatment Outcome; Young Adult | 2020 |
TAM family receptors in conjunction with MAPK signalling are involved in acquired resistance to PI3Kα inhibition in head and neck squamous cell carcinoma.
Topics: Animals; Apoptosis; Axl Receptor Tyrosine Kinase; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; MAP Kinase Signaling System; Mice; Prognosis; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Squamous Cell Carcinoma of Head and Neck; Survival Rate; Thiazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
PI3k inhibitors (BKM120 and BYL719) as radiosensitizers for head and neck squamous cell carcinoma during radiotherapy.
Topics: Aminopyridines; Carcinoma, Squamous Cell; Cell Line, Tumor; Head and Neck Neoplasms; Humans; Morpholines; Neoplasm Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Radiation-Sensitizing Agents; Thiazoles | 2021 |
γ-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma.
Topics: Amyloid Precursor Protein Secretases; Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Proliferation; Diamines; Disease Models, Animal; Head and Neck Neoplasms; Humans; Immunosuppression Therapy; Mice; Mice, Knockout; Myeloid Cells; Protein Serine-Threonine Kinases; PTEN Phosphohydrolase; Receptor, Notch1; Receptor, Transforming Growth Factor-beta Type I; Receptors, Transforming Growth Factor beta; T-Lymphocytes, Regulatory; Thiazoles; Tumor Cells, Cultured; Tumor Escape | 2018 |
Bosutinib Inhibits EGFR Activation in Head and Neck Cancer.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Drug Combinations; Drug Synergism; ErbB Receptors; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Injections, Subcutaneous; Mice; Mice, Nude; Nitriles; Proto-Oncogene Proteins c-abl; Quinolines; Signal Transduction; src-Family Kinases; Thiazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2018 |
ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition.
Topics: Cell Cycle; Cell Line, Tumor; Drug Resistance, Neoplasm; Genes, ras; Head and Neck Neoplasms; Humans; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mechanistic Target of Rapamycin Complex 1; Molecular Targeted Therapy; Mutation, Missense; Neoplasm Proteins; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Ribosomal Protein S6 Kinases; RNA Interference; Squamous Cell Carcinoma of Head and Neck; Thiazoles; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein | 2018 |
Repression of AXL expression by AP-1/JNK blockage overcomes resistance to PI3Ka therapy.
Topics: Animals; Anthracenes; Antineoplastic Agents; Axl Receptor Tyrosine Kinase; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Esophageal Neoplasms; Head and Neck Neoplasms; Humans; JNK Mitogen-Activated Protein Kinases; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, SCID; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Squamous Cell Carcinoma of Head and Neck; Thiazoles; Tongue; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Xenograft Model Antitumor Assays | 2019 |
Cisplatin enhances the efficacy of 5-aminolevulinic acid mediated photodynamic therapy in human head and neck squamous cell carcinoma.
Topics: Aminolevulinic Acid; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Cisplatin; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Synergism; Female; Head and Neck Neoplasms; Humans; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Tetrazolium Salts; Thiazoles; Xenograft Model Antitumor Assays | 2014 |
Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction.
Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cyclin D; Flow Cytometry; G1 Phase Cell Cycle Checkpoints; Head and Neck Neoplasms; Humans; Mitochondria; rho GTP-Binding Proteins; Sesquiterpenes; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53 | 2013 |
Increased killing of SCCVII squamous cell carcinoma cells after the combination of Pc 4 photodynamic therapy and dasatinib is associated with enhanced caspase-3 activity and ceramide synthase 1 upregulation.
Topics: Abdominal Neoplasms; Acid Ceramidase; Amino Acid Chloromethyl Ketones; Animals; Annexin A5; Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Caspase 9; Cell Line, Tumor; Ceramides; Dasatinib; Enzyme Activation; Head and Neck Neoplasms; Indoles; Mice; Mice, Inbred C3H; Mitochondria; Oxidoreductases; Photochemotherapy; Propidium; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; RNA, Messenger; Sphingosine; Thiazoles | 2013 |
Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines.
Topics: Antineoplastic Agents; Butadienes; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; Dasatinib; Drug Screening Assays, Antitumor; Head and Neck Neoplasms; Humans; Imidazoles; Isoxazoles; Leflunomide; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Nitriles; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Radiation Tolerance; STAT5 Transcription Factor; STAT6 Transcription Factor; Thiazoles; Tumor Suppressor Proteins | 2013 |
Metformin sensitizes anticancer effect of dasatinib in head and neck squamous cell carcinoma cells through AMPK-dependent ER stress.
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Squamous Cell; Cell Growth Processes; Cell Line, Tumor; Dasatinib; Drug Synergism; Endoplasmic Reticulum Stress; Female; Head and Neck Neoplasms; Humans; Metformin; Mice; Mice, Nude; Pyrimidines; Squamous Cell Carcinoma of Head and Neck; Thiazoles; Xenograft Model Antitumor Assays | 2014 |
Inhibition of SphK1 reduces radiation-induced migration and enhances sensitivity to cetuximab treatment by affecting the EGFR / SphK1 crosstalk.
Topics: Aged; Aged, 80 and over; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cetuximab; Disease Progression; ErbB Receptors; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Paraffin Embedding; Phosphotransferases (Alcohol Group Acceptor); Receptor Cross-Talk; Signal Transduction; Squamous Cell Carcinoma of Head and Neck; Thiazoles | 2014 |
In vitro anticancer activity of PI3K alpha selective inhibitor BYL719 in head and neck cancer.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Drug Synergism; Head and Neck Neoplasms; Humans; Phosphoinositide-3 Kinase Inhibitors; Quinazolinones; Thiazoles | 2015 |
AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas.
Topics: Animals; Antibodies, Monoclonal, Humanized; Axl Receptor Tyrosine Kinase; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Class I Phosphatidylinositol 3-Kinases; Drug Resistance, Neoplasm; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Head and Neck Neoplasms; Humans; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2015 |
Cytotoxic effects of SMAC-mimetic compound LCL161 in head and neck cancer cell lines.
Topics: Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Drug Therapy, Combination; Fas Ligand Protein; fas Receptor; Flow Cytometry; Head and Neck Neoplasms; Humans; Inhibitor of Apoptosis Proteins; Thiazoles | 2016 |
NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Self Renewal; Cisplatin; Diamines; Docetaxel; Drug Synergism; Drug Therapy, Combination; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplastic Stem Cells; Receptor, Notch1; RNA, Small Interfering; Taxoids; Thiazoles; Xenograft Model Antitumor Assays | 2016 |
Notch1 regulates invasion and metastasis of head and neck squamous cell carcinoma by inducing EMT through c-Myc.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antigens, CD; Cadherins; Carcinogenesis; Carcinoma, Squamous Cell; Cell Enlargement; Cell Line, Tumor; Diamines; Epithelial-Mesenchymal Transition; Female; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Prognosis; Proto-Oncogene Proteins c-myc; Receptor, Notch1; Squamous Cell Carcinoma of Head and Neck; Thiazoles; Vimentin; Young Adult | 2017 |
Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma.
Topics: Animals; Carcinoma, Squamous Cell; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Drug Delivery Systems; Head and Neck Neoplasms; Humans; Mice, Nude; Microscopy, Electron, Scanning; Nanoparticles; Protein Kinase Inhibitors; Thiazoles; Treatment Outcome; Xenograft Model Antitumor Assays | 2017 |
Sustained Src inhibition results in signal transducer and activator of transcription 3 (STAT3) activation and cancer cell survival via altered Janus-activated kinase-STAT3 binding.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dasatinib; Head and Neck Neoplasms; Humans; Janus Kinase 2; Mice; Phosphorylation; Pyrimidines; src-Family Kinases; STAT3 Transcription Factor; Thiazoles; TYK2 Kinase | 2009 |
Mammalian target of rapamycin (mTOR) is involved in the survival of cells mediated by chemokine receptor 7 through PI3K/Akt in metastatic squamous cell carcinoma of the head and neck.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Squamous Cell; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Survival; Chemokine CCL19; Chromones; Cisplatin; Coloring Agents; Enzyme Inhibitors; Flow Cytometry; Head and Neck Neoplasms; Humans; Intracellular Signaling Peptides and Proteins; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Polymerase Chain Reaction; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Receptors, CCR7; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Tetrazolium Salts; Thiazoles; TOR Serine-Threonine Kinases | 2010 |
Targeting polo-like kinase 1 enhances radiation efficacy for head-and-neck squamous cell carcinoma.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Caspase 3; Caspase 7; Cell Cycle Proteins; Cell Line, Tumor; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p21; Female; Head and Neck Neoplasms; Histones; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; RNA, Messenger; RNA, Small Interfering; Tetrazolium Salts; Thiazoles; Transfection; Tumor Stem Cell Assay | 2010 |
Dasatinib blocks cetuximab- and radiation-induced nuclear translocation of the epidermal growth factor receptor in head and neck squamous cell carcinoma.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Carcinoma; Carcinoma, Squamous Cell; Cell Line, Tumor; Cetuximab; Dasatinib; ErbB Receptors; Head and Neck Neoplasms; Humans; Neoplasms, Squamous Cell; Protein Kinase Inhibitors; Protein Transport; Pyrimidines; Squamous Cell Carcinoma of Head and Neck; Thiazoles | 2010 |
Increased radiation sensitivity of head and neck squamous cell carcinoma with sphingosine kinase 1 inhibition.
Topics: Animals; Apoptosis; Blotting, Western; Carcinoma; Carcinoma, Squamous Cell; Disease Models, Animal; Enzyme Inhibitors; Head and Neck Neoplasms; Humans; Immunohistochemistry; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Squamous Cell; Phosphotransferases (Alcohol Group Acceptor); Polymerase Chain Reaction; Radiation Tolerance; Squamous Cell Carcinoma of Head and Neck; Thiazoles; Treatment Outcome | 2011 |
Lyn kinase mediates cell motility and tumor growth in EGFRvIII-expressing head and neck cancer.
Topics: Animals; Antibodies, Monoclonal; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; CSK Tyrosine-Protein Kinase; Dasatinib; Disease Progression; ErbB Receptors; Head and Neck Neoplasms; Humans; Immunoprecipitation; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Transplantation; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-yes; Pyrimidines; Random Allocation; RNA Interference; RNA, Small Interfering; Squamous Cell Carcinoma of Head and Neck; src-Family Kinases; Thiazoles; Transplantation, Heterologous | 2012 |
Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Dasatinib; Drug Resistance, Neoplasm; ErbB Receptors; Estrogen Receptor alpha; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Inhibitory Concentration 50; Lysosomes; Male; Mice; Mice, Nude; Protein Kinase Inhibitors; Proteolysis; Proto-Oncogene Proteins c-akt; Pyrimidines; src-Family Kinases; Thiazoles; Xenograft Model Antitumor Assays | 2012 |
Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways.
Topics: Active Transport, Cell Nucleus; Apoptosis; Carcinoma, Squamous Cell; Cell Cycle; Cell Nucleus; CSK Tyrosine-Protein Kinase; Dasatinib; DNA Repair; ErbB Receptors; Focal Adhesion Protein-Tyrosine Kinases; Head and Neck Neoplasms; Humans; Protein Kinase Inhibitors; Pyrimidines; Radiation Tolerance; Squamous Cell Carcinoma of Head and Neck; src-Family Kinases; Thiazoles | 2012 |
Retinoic acid modulates the radiosensitivity of head-and-neck squamous carcinoma cells grown in collagen gel.
Topics: Cell Division; Collagen; Dose-Response Relationship, Drug; Endothelium, Vascular; Epithelial Cells; Gels; Head and Neck Neoplasms; Humans; Hyaluronic Acid; Immunohistochemistry; Phenotype; Tetrazolium Salts; Thiazoles; Time Factors; Tretinoin; Tumor Cells, Cultured | 2002 |
Microsomal prostaglandin E synthase-1 is overexpressed in head and neck squamous cell carcinoma.
Topics: Blotting, Western; Carcinoma, Squamous Cell; Cell Line; Cell Transformation, Neoplastic; Coloring Agents; Head and Neck Neoplasms; Humans; Immunoblotting; Immunohistochemistry; Intramolecular Oxidoreductases; Microsomes; Mucous Membrane; Prognosis; Prostaglandin-E Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
Antitumor effects of epidermal growth factor receptor antisense oligonucleotides in combination with docetaxel in squamous cell carcinoma of the head and neck.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blotting, Western; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; Coloring Agents; DNA-Binding Proteins; Docetaxel; Dose-Response Relationship, Drug; Down-Regulation; ErbB Receptors; Female; Head and Neck Neoplasms; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Neoplasm Transplantation; Oligonucleotides, Antisense; Phosphotyrosine; Signal Transduction; STAT3 Transcription Factor; Taxoids; Tetrazolium Salts; Thiazoles; Time Factors; Trans-Activators; Vascular Endothelial Growth Factor A | 2003 |
The relationship of the human glutathione S-transferase P1 polymorphism and chemotherapeutic sensitivity in head and neck squamous carcinoma.
Topics: Alleles; Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cisplatin; Drug Resistance, Multiple; Exons; Genotype; Glutathione Transferase; Head and Neck Neoplasms; Heterozygote; Humans; Inhibitory Concentration 50; Polymorphism, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Tetrazolium Salts; Thiazoles; Valine | 2004 |
Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas.
Topics: Animals; Apoptosis; Carcinoma, Squamous Cell; Cell Division; Cell Line, Tumor; Ceramides; Chromatography, Liquid; Coloring Agents; DNA, Complementary; Head and Neck Neoplasms; Humans; Mass Spectrometry; Membrane Potentials; Membrane Proteins; Mice; Mitochondria; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saccharomyces cerevisiae Proteins; Sphingosine N-Acyltransferase; Telomerase; Tetrazolium Salts; Thiazoles; Trypan Blue | 2004 |
In vitro effects of the BH3 mimetic, (-)-gossypol, on head and neck squamous cell carcinoma cells.
Topics: Apoptosis; bcl-X Protein; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dimerization; Dose-Response Relationship, Drug; Drug Resistance; Fibroblasts; Gossypol; Head and Neck Neoplasms; Humans; In Situ Nick-End Labeling; Inhibitory Concentration 50; Peptide Fragments; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Suppressor Protein p53 | 2004 |
Reduced cisplatin sensitivity of head and neck squamous cell carcinoma cell lines correlates with mutations affecting the COOH-terminal nuclear localization signal of p53.
Topics: Adult; Aged; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Nucleus; Cisplatin; Cloning, Molecular; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cytoplasm; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Electrophoresis, Polyacrylamide Gel; Genes, p53; Head and Neck Neoplasms; Humans; Immunohistochemistry; Microscopy, Confocal; Middle Aged; Models, Molecular; Mutation; Nuclear Localization Signals; Open Reading Frames; Protein Structure, Tertiary; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53 | 2005 |
Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Collagen; Crk-Associated Substrate Protein; Dasatinib; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; G1 Phase; Gentian Violet; Head and Neck Neoplasms; Humans; Immunoprecipitation; Inhibitory Concentration 50; Laminin; Lung Neoplasms; Neoplasm Invasiveness; Neovascularization, Pathologic; Paxillin; Phosphorylation; Protein-Tyrosine Kinases; Proteoglycans; Pyrimidines; Retinoblastoma Protein; S Phase; Signal Transduction; src-Family Kinases; Thiazoles; Time Factors; Trypan Blue | 2005 |
Curcumin suppresses growth of head and neck squamous cell carcinoma.
Topics: Animals; Annexin A5; Antineoplastic Agents; Blotting, Western; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Nucleus; Cell Separation; Cell Survival; Curcumin; Cyclin D1; Dose-Response Relationship, Drug; Female; Flow Cytometry; Head and Neck Neoplasms; Humans; I-kappa B Proteins; In Vitro Techniques; Mice; Mice, Nude; Microscopy, Fluorescence; Neoplasm Transplantation; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Tetrazolium Salts; Thiazoles | 2005 |
Autocrine and paracrine chemokine receptor 7 activation in head and neck cancer: implications for therapy.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Apoptosis; Autocrine Communication; Biomarkers, Tumor; Carcinoma, Squamous Cell; Chemokine CCL19; Chemokine CCL21; Cisplatin; Disease Models, Animal; Disease Progression; ErbB Receptors; Female; Formazans; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Humans; Immunohistochemistry; Male; Mice; Middle Aged; Paracrine Communication; Receptors, CCR7; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tetrazolium Salts; Thiazoles; Up-Regulation | 2008 |
Treatment of cancer by an inducer of reverse transformation.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Carboxylic Acids; Carcinoma, Squamous Cell; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Head and Neck Neoplasms; Humans; Infusions, Parenteral; Injections, Intramuscular; Injections, Intravenous; Male; Middle Aged; Neoplasms; Thiazoles; Thiazolidines | 1980 |
Phase II trial of thioproline in advanced epidermoid head and neck tumors.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Nervous System Diseases; Thiazoles; Thiazolidines | 1982 |
Thioproline (Norgamem): a useless drug in the treatment of squamous cell carcinoma.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Evaluation; Head and Neck Neoplasms; Humans; Lung Neoplasms; Thiazoles; Thiazolidines | 1981 |
IL (interleukin)-1alpha promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas.
Topics: Carcinoma, Squamous Cell; Cell Division; Cell Survival; Coloring Agents; Enzyme-Linked Immunosorbent Assay; Genes, Reporter; Genetic Vectors; Head and Neck Neoplasms; Humans; Interleukin-1; Interleukin-8; Mutation; NF-kappa B; Plasmids; Recombinant Proteins; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factor AP-1; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2001 |
Prediction of survival in patients with head and neck cancer using the histoculture drug response assay.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Survival; Cisplatin; Drug Monitoring; Female; Fluorouracil; Head and Neck Neoplasms; Humans; Male; Middle Aged; Survival Rate; Tetrazolium Salts; Thiazoles; Time Factors; Treatment Outcome | 2002 |
Comparison of the sulforhodamine B protein and tetrazolium (MTT) assays for in vitro chemosensitivity testing.
Topics: Calorimetry; Carcinoma, Squamous Cell; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Head and Neck Neoplasms; Humans; Rhodamines; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1991 |
Evaluation of tetrazolium-based semiautomatic colorimetric assay for measurement of human antitumor cytotoxicity.
Topics: Carcinoma, Squamous Cell; Cell Adhesion; Cell Count; Cell Survival; Chromium Radioisotopes; Colorimetry; Evaluation Studies as Topic; Head and Neck Neoplasms; Humans; Immunity, Cellular; Killer Cells, Lymphokine-Activated; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured | 1990 |