thiazoles has been researched along with Breast Neoplasms in 361 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (0.83) | 18.7374 |
1990's | 31 (8.59) | 18.2507 |
2000's | 108 (29.92) | 29.6817 |
2010's | 160 (44.32) | 24.3611 |
2020's | 59 (16.34) | 2.80 |
Authors | Studies |
---|---|
Kanno, Y; Kizu, R; Ozawa, M; Sanada, N; Taga, C; Yamashita, N | 1 |
Fu, A; Huang, R; Liang, J; Tang, M; Wang, L; Zhou, J | 1 |
Balic, M; Bartsch, R; Dandachi, N; Gerritsmann, H; Graf, R; Heitzer, E; Jahn, S; Jost, PJ; Kashofer, K; Klocker, EV; Lindenmann, J; Posch, F; Regitnig, P; Suppan, C; Terbuch, A; Zhou, Q | 1 |
Chen, C; Chen, X; Chi, L; Guo, X; Guo, Z; He, J; Liang, J; Wei, L; Ye, X; Zheng, Y | 1 |
Chin, CM; Scarim, CB | 1 |
Cheung, YM; Cromwell, GE; McDonnell, ME; Min, L; Tolaney, SM | 1 |
Aapro, MS; Goncalves, MD; Lacouture, ME; Masharani, U; O'Shaughnessy, JA; Rugo, HS | 1 |
Jacobson, A | 1 |
Adam, V; Bedard, PL; Carrasco, E; Criscitiello, C; Di Leo, A; Pérez-Fidalgo, JA; Regan, MM; Ribi, K | 1 |
Abdel-Aziz, HA; Abdelmoaz, MA; Al-Warhi, T; Albohy, A; Aljaeed, N; El Kerdawy, AM; Eldehna, WM; Elkaeed, EB; Elsayed, ZM; Said, MA | 1 |
Eisner, JR; Lerner, LM; Michmerhuizen, AR; Pesch, AM; Pierce, LJ; Rae, JM; Schwartz, R; Speers, CW; Ward, C; Wilder-Romans, K; Zhang, A | 1 |
Blackley, EF; Bujak, AZ; Callahan, J; Dawson, SJ; Francis, PA; Ftouni, S; Hicks, RJ; Ko, YA; Lee, CK; Lo, LL; Loi, S; Luen, SJ; Moodie, K; Savas, P; Silva, MJ; van Geelen, CT; Wein, L; Weng, CF; Yeung, MM | 1 |
Alessandrini, G; Blandino, G; Botti, C; Carosi, M; Ciliberto, G; Cioce, M; Daralioti, T; Di Martino, S; Donzelli, S; Fazio, VM; Goeman, F; Orlandi, G; Piccolo, S; Sacconi, A; Strano, S; Telera, S; Zanconato, F | 1 |
Fan, X; Jiang, Z; Li, M; Lu, Q; Yu, Q; Zhang, L; Zhao, W; Zhu, Y | 1 |
Bauer, M; Climova, A; Czylkowska, A; Dzięgielewski, M; Jóźwiak, P; Kamysz, W; Krześlak, A; Pivovarova, E; Staszewski, M; Świątkowski, M; Walczyński, K | 1 |
Kaderbhaï, CG; Royer, B; Schmitt, A | 1 |
Huang, Z; Li, J; Lou, C; Ye, Y; Zhang, M; Zhang, Y | 1 |
Park, J; Shin, SW | 1 |
Copur, MS; Jonglertham, P | 1 |
André, F; Mills, D; Taran, T | 1 |
Melegari, E; Palleschi, M; Rocca, A | 1 |
Aschenbrenner, DS | 1 |
Antoine, A; Baselga, J; Cantley, LC; Chandarlapaty, S; Chang, MT; Dickler, MN; Friedman, LS; Gorelick, A; Jhaveri, K; Johnson, JL; Kazmi, A; Ladewig, E; Lin, TY; Rabadan, R; Razavi, P; Reznik, E; Scaltriti, M; Schimmoller, F; Sebra, R; Shah, H; Shao, H; Smith, ML; Taylor, BS; Toska, E; Vasan, N; Wilson, TR; Xu, G | 1 |
Jin, G; Liu, X; Liu, Y; Wang, K; Zhang, H; Zhang, X | 1 |
Adler, B; Bass, IR; Gallagher, EJ; Ryncarz, A; Tiersten, A; Trlica, K | 1 |
Hirao-Suzuki, M; Koga, T; Takeda, S; Takiguchi, M; Toda, A | 1 |
Abbasnezhad, A; Abd El-Ghafar, OA; Abhilash, L; Abouzid, KAM; Achberger, AM; Ackerman, S; Akhatayeva, Z; Akin, D; Al-Kaysi, RO; Alakhdar, AA; Alame, M; Aleksic Sabo, V; Alinezhadbalalami, N; Allen, JD; Alonso, JM; Alqatani, S; Alsayed, B; Álvarez Larraondo, M; Alvarez, M; Amini, SB; An, Z; Anasir, MI; Anderson, GH; Andremont, A; Andrés, S; Angel, S; Anigboro, AA; Anini, Y; Antonides, CFJ; Arafa, K; Arafa, RK; Aryal, UK; Asbaghi, O; Assefa, MK; Atyah, M; Avwioroko, OJ; Ayora-Talavera, G; Azpilikueta, A; Azyazov, VN; Ba, YF; Bachmann, KF; Badoual, J; Bae, SJ; Baek, SH; Bahrami, B; Bai, J; Baid-Agrawal, S; Bailey, MR; Baillie, JK; Balani, N; Balcar, VJ; Banica, T; Banks, L; Barb, J; Bardeen, CJ; Barrett, HE; Bartnikowski, N; Bashir, R; Battaglia, M; Bautista-Hernández, V; Becker, B; Beekman, FJ; Benidir, M; Benjelloun, M; Bentley, RF; Bergé, J; Berger, D; Bernsen, MR; Berraondo, P; Bhattacharya, R; Bhayani, SB; Bi, W; Bi, X; Bi, YL; Bi, Z; Bian, K; Biesecker, LG; Billadeau, DD; Blaszczyk, R; Blum, JL; Boachie, R; Boelte, K; Bogers, AJJC; Boileau, I; Bonduelle, C; Bonny, O; Bonsu, JM; Boos, LA; Borges-Argáez, R; Bouchard, PA; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Boyle, AJ; Branigan, D; Briones, S; Broniowska, KA; Brossas, JY; Brown, WA; Brzezinska, J; Buitron, G; Burnier, M; Bursulaya, B; Burton, PR; Bush, AA; Busuttil, RW; Cabello-Aguilar, S; Cáceres-Farfán, M; Cacheux, V; Caffrey, PJ; Cai, B; Cai, Q; Cai, S; Cai, Y; Calders, P; Cammarota, G; Campbell, DA; Cancelli, C; Cao, Q; Cao, WH; Cao, X; Capet, M; Capoluongo, E; Carey, ME; Carnero, M; Carrasco, LI; Carreno, J; Carrillo-Reyes, J; Casini, I; Cassar, M; Catalan, G; Cattamanchi, A; Cazares-Granillo, M; Celie, B; Cen, YK; Cena, H; Cerbo, RM; Ceron, E; Cetina-Montejo, L; Chaâbane-Banaoues, R; Chabanet, C; Chace-Donahue, F; Chalfun-Júnior, A; Chan-Balan, R; Chang, CS; Chen, CS; Chen, D; Chen, J; Chen, L; Chen, PN; Chen, Q; Chen, S; Chen, W; Chen, WP; Chen, X; Chen, Z; Cheng, H; Cheng, J; Cheng, Q; Cheng, T; Chi, T; Chianelli, D; Chieppa, M; Child, CJ; Cho, JH; Cho, JY; Chogtu, B; Choi, GH; Choi, J; Choi, M; Choi, NG; Cholu, CO; Chow, ES; Chowdhury, AH; Chu, PC; Chu, Q; Chu, S; Chua, H; Chung, T; Chunyan, L; Church, JS; Civardi, E; Cobiella, J; Colinge, J; Collado, CJ; Collins, TJ; Cong, LM; Conkrite, KL; Cope, SJ; Corbett, JA; Cornet, M; Cornillot, E; Corvaisier, S; Costes-Martineau, V; Courtioux, B; Coussens, M; Covino, M; Criado, A; Cui, J; Cui, Y; Cunitz, BW; Curry, AE; Cussó, L; D'Urzo, AD; D'Urzo, KA; Dabbous, S; Dahlgren, RA; Dai, H; Dai, T; Dai, W; Dalinghaus, M; Dang, S; Davalos, RV; Davidson, H; de Andrea, CE; De Angelis, M; de Blois, E; de Carvalho, PA; De Clercq, E; De Giuseppe, R; de Jong, M; De Langhe, S; De Oliveira, L; de Souza Pinto Lemgruber, R; de Souza, LB; de Swart, J; De Wandele, I; de Woestijne, PCV; Delaney, S; Delorme, M; Delvenne, P; Deng, L; Deng, Z; Denkinger, CM; der Meulen, MHV; Deraeve, C; Desco, M; DeSilva, S; Destere, A; Dhali, A; Di Ciano, P; Dias-Santagata, D; Diskin, SJ; Djè, MK; Doddipatla, S; Doerr, AJ; Dokla, EME; Domiciano, D; Domingo, N; Dong, C; Dong, J; Dong, Q; Dong, S; Dong, X; Dong, Z; Douair, I; Douglas, TA; Doyle, SM; Drain, PK; Du, K; Du, L; Du, Q; Du, S; Duan, C; Duan, H; Duan, J; Duan, S; Duan, W; Dueluzeau, R; Dukic, L; Dunmire, BL; Duvauchelle, T; Dymek, B; Dzwonek, K; Earnest, A; Eckardt, KU; El Ghadraoui, L; El Massoudi, S; Elloumi, F; Elnour, IE; Embarak, S; Ende, M; England, K; Enikeev, D; Enyedy, I; Epple, R; Erickson, GE; Eriksson, J; Erndt-Marino, J; Errachidi, F; Etxeberria, I; Evan, AP; Fairlamb, AH; Falahi, E; Fan, CC; Fan, H; Fan, M; Fan, MZ; Fan, S; Fan, Y; Fang, CS; Fang, J; Fang, X; Fang, Z; Farmany, A; Farooqi, A; Farouk, HO; Fazelipour, S; Feng, D; Feng, J; Feng, JX; Feng, YL; Ferraz, SL; Ferreira, CR; Figenshau, RS; Finn, AV; Fiseha, T; Fleischer, AS; Fogleman, AD; Fontaine, O; Ford, CR; Fouladvand, F; Four, M; Fousteri, G; Francis, JR; Fraser, JF; Frazier, RP; Fu, H; Fu, P; Fu, YJ; Fujishima, A; Fuster, V; Gabilan, JC; Gagliani, N; Gai, QY; Galán-Arriola, C; Gale, P; Galimova, GR; Galkin, A; Gallo, A; Gallo, AA; Gang, DD; Ganschow, S; Gao, C; Gao, F; Gao, GP; Gao, H; Gao, K; Gao, M; Gao, MY; Gao, P; Gao, R; Gao, S; Gao, WJ; Gao, Y; Garbacz, P; García Ruiz, L; Garcia, EM; Garofoli, F; Gasbarrini, A; Gattinoni, L; Gaudig, M; Gbureck, U; Ge, X; Genko, N; Gentile, GL; George, MW; Gerety, GF; Gestwicki, JE; Geusens, PP; Ghassemi, M; Giardina, JD; Giebultowicz, JM; Gifford, CA; Gijsen, FJH; Gilfillan, R; Gilson, E; Gingl, K; Giuliano, C; Glybochko, P; Goessler, W; Gofflot, S; Golab, J; Goldstein, A; Golebiowski, A; Gómez, L; Gómez-Carballo, J; Gonçalves, PEO; Gonzales, R; Gonzalez-Cotto, M; González-Fernández, D; Gonzalez-Lopez de Turiso, F; Goodman, JM; Govinda Raju, S; Grimm, J; Gross, AJ; Gruenheid, S; Gu, C; Gu, FF; Gu, S; Gu, Z; Guest, RL; Gui, C; Gui, J; Guillem, A; Guo, G; Guo, L; Guo, Q; Guo, S; Guo, SW; Guo, W; Guo, Y; Guo, YG; Guo, Z; Guretzky, JA; Haenggi, M; Hahn, MS; Hakkola, J; Halim, AA; Hampel, D; Han, B; Han, BH; Han, D; Han, G; Han, J; Han, LZ; Han, R; Han, S; Han, X; Han, Z; Handley, MA; Hanke, I; Hannongbua, S; Hao, P; Happ, JT; Hara, M; Haraux, F; Hare, JL; Harper, JD; Hartley, AM; Harvey, E; Hashimoto, K; Hassan, HM; Hautajärvi, H; Hayton, TW; He, C; He, H; He, HJ; He, WP; He, Y; He, Z; Hedrick, V; Heffernan, JK; Hegrová, J; Heidarimoghadam, R; Helms, K; Hengphasatporn, K; Henry, D; Herrmann, TRW; Hesson, T; Himmelbauer, MK; Hindle, A; Hoffmann, R; Hogg, N; Hong, KB; Hong, SK; Honjol, Y; Hood, C; Hsi, RS; Hsu, JL; Hu, B; Hu, BC; Hu, D; Hu, H; Hu, J; Hu, K; Hu, M; Hu, MK; Hu, T; Hu, W; Hu, Y; Hu, Z; Hua, S; Huang, H; Huang, J; Huang, L; Huang, M; Huang, P; Huang, X; Huang, Y; Huang, Z; Hukkanen, J; Hung, MC; Huo, X; Hyötyläinen, T; Ianiro, G; Ibanez, B; Imran, M; Ireland, S; Irwin, MS; Ishiguro, H; Jackowski, K; Jackson, C; Jacob, SI; Jahromy, MH; Jakob, SM; Jang, J; Javvaji, PK; Jefferson, KK; Jena, P; Ji, H; Jiang, F; Jiang, GH; Jiang, H; Jiang, J; Jiang, X; Jiang, Z; Jiao, J; Jiménez, A; Jin, X; Jincai, W; Jintao, X; Jo, K; Jofra, T; Johari, Y; Johnson, ACM; Jones, JH; Josephine Fauci, A; Juhl, AK; Jun, S; Kaiser, RI; Kajioka, J; Kajiyama, H; Kalliyil, A; Kalthur, SG; Kamalanathan, M; Kamaldinov, T; Kanaani, L; Kang, D; Kang, J; Kang, S; Känsäkoski, P; Kaplan, DL; Karwan, M; Kasibhatla, S; Kaur, A; Kawazoe, Y; Ke, C; Keyser, J; Khalique, A; Khan, IT; Kharshoum, RM; Kher, R; Kherani, J; Ki, KK; Kikkawa, F; Kikkawa, R; Kim, BT; Kim, EH; Kim, GA; Kim, GD; Kim, HB; Kim, HG; Kim, JS; Kim, MJ; Kim, SI; Kim, SJ; Kim, Y; King, K; Kinyamu-Akunda, J; Kirkkala, T; Kjaer-Sorensen, K; Kleppinger, EL; Kloner, RA; Klopfenstein, TJ; Knappe, D; Knezevic, P; Kobos, LM; Kohli, M; Kolano, L; Kolodgie, FD; Kolte, AP; Koneru, B; Kong, D; Kong, F; Kong, X; Konggidinata, MI; Köpke, M; Koski, KG; Kotsis, F; Köttgen, A; Kouakou-Kouamé, CA; Kraemer, US; Krane, V; Krehbiel, CR; Krenning, BJ; Kretzschmar, D; Ku, KB; Kubota, Y; Kulich, P; Kumar, NG; Kupiec-Weglinski, JW; Lalani, SS; Lan, X; Landfeldt, E; Langenberg, E; Lapauw, B; Larkin, J; Lassoued, MA; Laukhtina, E; Laura Martinez, J; Laveillé, A; Lavela, P; Law, AD; Lazraq, A; Le Foll, B; Lee, BK; Lee, C; Lee, CS; Lee, EJ; Lee, EY; Lee, G; Lee, HY; Lee, JH; Lee, JJ; Lee, JO; Lee, JS; Lee, R; Lei, H; Lei, P; Lellouche, F; Lennerz, JK; Leong, W; Leslie, I; Lessem, E; Levin, M; Levinger, I; Li, C; Li, CW; Li, CX; Li, CY; Li, D; Li, H; Li, HM; Li, J; Li, L; Li, LM; Li, N; Li, S; Li, W; Li, X; Li, XX; Li, Y; Li, Z; Li, ZL; Li, ZX; Lian, Q; Liang, C; Liang, GH; Liang, H; Liang, J; Liang, X; Liao, CX; Liao, R; Ličbinský, R; Lim, YS; Lima, HK; Lin, JG; Lin, L; Lin, S; Lin, WP; Lin, Z; Liso, M; Liu, BX; Liu, C; Liu, H; Liu, J; Liu, M; Liu, Q; Liu, S; Liu, SF; Liu, SL; Liu, T; Liu, W; Liu, X; Liu, XB; Liu, Y; Liu, YY; Liu, Z; Liu, ZQ; Lobo, M; Loitzenbauer, M; López, F; Lopez, G; López, GJ; Lou, Z; Lu, IC; Lu, J; Lu, M; Lu, W; Lu, X; Lu, Y; Luhovyy, BL; Luna-Abanto, J; Luo, J; Luo, K; Luo, L; Luo, M; Luo, W; Luo, X; Luo, XM; Lv, Y; Lv, YQ; Lyu, HD; Lyu, J; Ma, C; Ma, G; Ma, L; Ma, Q; Ma, X; Ma, Y; Macha, SJ; MacLean, E; Mahalapbutr, P; Maina, T; Malfait, F; Malfertheiner, MV; Malzert-Fréon, A; Mansouri, E; Mao, C; Marcellin, E; Marchiori, PER; Marcotte, DJ; Maréchal, A; Maric, N; Maris, JM; Maron, L; Marti, CN; Martínez-Milla, J; Mateo, J; Mather, K; Mathison, CJN; Matthay, MA; Maxwell, CL; Mazier, D; Mazumder, D; Mazurkiewicz, M; Mazzucchelli, TG; McAuley, DF; Mccoy, K; McVicar, DW; Mebel, AM; Mech, A; Meester, EJ; Meiselbach, H; Melero, I; Ménard, G; Meng, X; Mengya, Y; Merle, G; Meunier, B; Mfarrej, B; Mi, K; Migueliz, I; Mikuška, P; Miladi, K; Miletich, R; Millar, JE; Mills, MR; Milne, R; Minute, L; Misiak, M; Mo, F; Modi, A; Mok, F; Molina, C; Mollen, CJ; Molteni, V; Montalto, M; Montet, D; Monti, MC; Moor, MB; Moravec, P; Morsiani, C; Murillo, E; Murugan, P; Muslem, R; Myers, RK; N'guessan, FK; Nabil, H; Nadal, J; Nadeem, M; Nafady, MM; Nafie, MS; Nair, HP; Nakano, R; Nance, J; Naren, N; Neil, CJ; Nelson, J; Nery, FC; Netsch, C; Nguyen, TH; Ni, L; Ni, YX; Nie, W; Nielsen, LK; Nigam, K; Nikolayev, AA; Nishiyama, M; Niu, LL; Niu, PP; Nock, BA; Noer, PR; Noll, G; Noll, S; Norenberg, JP; Nowicka, J; Nutho, B; O'Connor, M; Obonyo, NG; Ochiai, T; Ochoa, MC; Oh, BL; Oh, S; Olczak, J; Olivares, X; Ommurugan, B; Oosthuizen, MC; Operario, D; Orešič, M; Oshima, K; Otano, I; Ou, Y; Owen, TW; Oxvig, C; Pacey, V; Pai, M; Paik, H; Paiva, R; Palmieri, EM; Palpant, N; Pan, L; Pan, Q; Panahi, S; Pang, B; Pang, ZC; Pannecouque, C; Paris, L; Park, D; Park, DJ; Park, E; Park, EC; Park, IH; Park, JH; Park, JI; Park, S; Passmore, MR; Pattaranggoon, NC; Paun, M; Pedersen, S; Pedron, J; Peng, M; Peng, X; Penzhorn, BL; Pérez-Camargo, D; Perez-Maldonado, R; Pérez-Vicente, C; Pham, TD; Pickering, L; Pickersgill, NA; Pinault, E; Pinotsis, N; Plan, M; Pocino, K; Poh, CL; Pons, EDC; Popoff, MR; Porri, D; Pourmand, A; Pratviel, G; Prudente, DO; Qi, H; Qi, N; Qian, LY; Qiao, L; Qiao, Q; Qin, QP; Qiu, N; Qiu, SW; Qu, F; Quan, M; Quigg, A; Raee, E; Raibaud, P; Ramanitrahasimbola, D; Rapoport, L; Rasby, RJ; Rasoanirina, BNV; Raspini, B; Ratner, JR; Razafindrakoto, Z; Redd, MA; Ren, H; Ren, N; Rey, J; Reynolds, CP; Rich, PR; Richards, CJ; Rigol, M; Rimoldi, S; Robert, P; Rodrigues, AE; Roe, JH; Rohde, S; Rokita, JL; Roland, J; Rombaut, L; Ronkainen, J; Rothenberg, SM; Roy, SC; Ruan, Z; Rucker, PV; Rueda, D; Ruhwald, M; Rungrotmongkol, T; Rupert, AS; Rusjan, P; Ryabov, AD; Rysä, J; Saad, NES; Sabioni, P; Sadow, PM; Sahai, N; Salem, HF; Salinas, B; Salonurmi, T; Samé Guerra, D; Sánchez, J; Sanchez-González, J; Sanmamed, MF; Sansores-Peraza, P; Santoro, JC; Santschi, PH; Saritas, T; Sarkisova, Y; Savolainen, MJ; Scherberich, JE; Schlom, DG; Schmelz, EM; Schmid, MC; Schneider, MP; Schumacher, S; Schwartz, JC; Schwartzer, JJ; Schwehr, K; Schweitzer, DH; Scott, ME; Sedky, NK; See Hoe, L; Sejian, V; Selvaraju, S; Sen, SK; Seo, G; Šerý, O; Settles, JA; Sfar, S; Shaffer, J; Shan, GL; Shang, Q; Shannahan, JH; Shao, B; Shao, H; Shao, J; Shao, ZH; Shasha, Y; Shaw, K; Sheeba, V; Shekar, K; Shen, G; Shen, H; Shen, XD; Shen, Y; Sherrell, PC; Shete, PB; Shi, AX; Shi, J; Shi, JH; Shi, S; Shi, X; Shigeta, Y; Shimbo, A; Shin, E; Sikka, N; Silhavy, TJ; Simanon, N; Simard, S; Simon, J; Simon, M; Simpson, SD; Simundic, AM; Since, M; Singh, B; Singhroy, DN; Sinisterra, OT; Smith, EH; Sobreira, TJP; Solanes, N; Somasundar, Y; Sommerer, C; Sonei, A; Song, B; Song, E; Song, J; Song, M; Song, Y; Soo Lee, M; Sorensen, MD; Sournia-Saquet, A; Spaepen, E; Spirk, D; Srivastava, S; Stancill, JS; Stanczak, PS; Starenki, D; Starr, F; Step, DL; Steubl, D; Stigliani, JL; Stráská, J; Sträter, N; Su, ZZ; Sudano, I; Suen, JY; Suh, HJ; Sui, ZY; Suico, JG; Suleiman, K; Sumon, K; Sun, HB; Sun, J; Sun, L; Sun, LL; Sun, M; Sun, Q; Sun, W; Sun, X; Sun, XF; Sun, Y; Sun, YB; Sun, YH; Sun, YN; Sun, Z; Sunada, K; Suzuki, S; Sylvan, JB; Takala, J; Talla, D; Tamir, Z; Tan, SJ; Tanda, S; Tang, H; Tang, J; Tang, LF; Tang, SJ; Tang, Y; Tao, FB; Tappel, R; 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13 review(s) available for thiazoles and Breast Neoplasms
Article | Year |
---|---|
Recent Trends in Drug Development for the Treatment of Adenocarcinoma Breast Cancer: Thiazole, Triazole, and Thiosemicarbazone Analogues as Efficient Scaffolds.
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Drug Development; Female; Humans; Thiazoles; Thiosemicarbazones; Triazoles | 2022 |
A multidisciplinary approach to optimizing care of patients treated with alpelisib.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Phosphatidylinositol 3-Kinases; Thiazoles | 2022 |
Pharmacokinetics and Pharmacodynamic of Alpelisib.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Fulvestrant; Humans; Phosphatidylinositol 3-Kinases; Receptor, ErbB-2; Thiazoles | 2023 |
Synergistic therapeutic potential of alpelisib in cancers (excluding breast cancer): Preclinical and clinical evidences.
Topics: Antineoplastic Agents; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Humans; Neoplasms; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Thiazoles | 2023 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Alpelisib to treat breast cancer.
Topics: Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Clinical Trials as Topic; Fulvestrant; Humans; Mutation; Receptor, ErbB-2; Thiazoles | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
Alpelisib in the treatment of metastatic HR+ breast cancer with
Topics: Breast Neoplasms; Chemotherapy, Adjuvant; Class I Phosphatidylinositol 3-Kinases; Clinical Trials as Topic; Drug Resistance, Neoplasm; Female; Humans; Mutation; Neoadjuvant Therapy; Progression-Free Survival; Protein Kinase Inhibitors; Receptors, Estrogen; Receptors, Progesterone; Thiazoles | 2021 |
Which Is the Most Appropriate PI3K Inhibitor for Breast Cancer Patients with or without PIK3CA Status Mutant? A Systematic Review and Network Meta-Analysis.
Topics: Aminopyridines; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Clinical Trials as Topic; Female; Humans; Morpholines; Mutation; Network Meta-Analysis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Progression-Free Survival; Signal Transduction; Thiazoles; Treatment Outcome | 2020 |
Observations with alpelisib in older patients (≥ 65 year of age) with breast cancer in a non-clinical trial setting.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Mutation; Thiazoles | 2021 |
Alpelisib: First Global Approval.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Drug Approval; Female; Fulvestrant; Humans; Male; Mutation; Protein Kinase Inhibitors; Receptor, ErbB-2; Thiazoles; United States; United States Food and Drug Administration | 2019 |
Cathepsin K inhibitors as treatment of bone metastasis.
Topics: Azepines; Benzamides; Biphenyl Compounds; Bone Neoplasms; Bone Remodeling; Bone Resorption; Breast Neoplasms; Cathepsin K; Cathepsins; Female; Humans; Male; Osteoclasts; Piperazines; Prostatic Neoplasms; Sulfones; Thiazoles | 2008 |
Predicting tumour response to anti-HER1 therapy using medical imaging: a literature review and in vitro study of [18F]-FDG incorporation by breast cancer cells responding to cetuximab.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cetuximab; Colony-Forming Units Assay; ErbB Receptors; Female; Fluorodeoxyglucose F18; Glucose; Hexokinase; Humans; Lactic Acid; Positron-Emission Tomography; Tetrazolium Salts; Thiazoles | 2011 |
26 trial(s) available for thiazoles and Breast Neoplasms
Article | Year |
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A phase III trial of alpelisib + trastuzumab ± fulvestrant versus trastuzumab + chemotherapy in HER2+
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Clinical Trials, Phase III as Topic; Female; Fulvestrant; Humans; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Receptors, Estrogen; Thiazoles; Trastuzumab | 2022 |
Alpelisib Monotherapy for PI3K-Altered, Pretreated Advanced Breast Cancer: A Phase II Study.
Topics: Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Humans; Mutation; Phosphatidylinositol 3-Kinases; Receptor, ErbB-2; Thiazoles; Triple Negative Breast Neoplasms | 2022 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Time course and management of key adverse events during the randomized phase III SOLAR-1 study of PI3K inhibitor alpelisib plus fulvestrant in patients with HR-positive advanced breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Fulvestrant; Humans; Male; Phosphatidylinositol 3-Kinases; Receptor, ErbB-2; Receptors, Estrogen; Thiazoles | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acrylic Resins; Actinobacillus; Acute Disease; Acute Kidney Injury; Adaptor Proteins, Signal Transducing; Adenosine; Adenosine Triphosphate; Administration, Inhalation; Administration, Oral; Adolescent; Adult; Advance Care Planning; Africa, Northern; Age Factors; Aged; Aged, 80 and over; Air Pollutants; Air Pollution; Air Pollution, Indoor; Albendazole; Aluminum Oxide; Anastomosis, Surgical; Ancylostoma; Ancylostomiasis; Androstadienes; Angiogenesis Inhibitors; Angiotensin II; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antibodies, Bispecific; Antibodies, Viral; Anticoagulants; Antihypertensive Agents; Antinematodal Agents; Antineoplastic Agents; Antineoplastic Agents, Immunological; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antiporters; Antiviral Agents; Apoptosis; Aptamers, Nucleotide; Aromatase Inhibitors; Asian People; Astrocytes; Atrial Fibrillation; Auditory Threshold; Aurora Kinase B; Australia; Autophagy; Autophagy-Related Protein 5; Autotrophic Processes; Bacillus cereus; Bacillus thuringiensis; Bacterial Proteins; Beclin-1; Belgium; Benzene; Benzene Derivatives; Benzhydryl Compounds; beta Catenin; beta-Arrestin 2; Biliary Tract Diseases; Biofilms; Biofuels; Biomarkers; Biomarkers, Tumor; Biomass; Biomechanical Phenomena; Bioreactors; Biosensing Techniques; Biosynthetic Pathways; Bismuth; Blood Platelets; Bone and Bones; Bone Regeneration; Bortezomib; Botulinum Toxins, Type A; Brain; Brain Injuries; Brain Ischemia; Brain Neoplasms; Breast Neoplasms; Breath Tests; Bronchodilator Agents; Calcium Phosphates; Cannabis; Carbon Dioxide; Carbon Isotopes; Carcinogenesis; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cardiac Resynchronization Therapy; Cardiac Resynchronization Therapy Devices; Cardiomyopathies; Cardiovascular Diseases; Cariostatic Agents; Case Managers; Case-Control Studies; Catalysis; Cation Transport Proteins; CD8-Positive T-Lymphocytes; Cecropia Plant; Cell Adhesion; Cell Count; Cell Differentiation; Cell Division; Cell Line; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Cell Self Renewal; Cell Survival; Cells, Cultured; Cellular Reprogramming; Cellulose; Charcoal; Chemical and Drug Induced Liver Injury; Chemical Phenomena; Chemokines; Chemoradiotherapy; Chemoreceptor Cells; Child; Child Abuse; Child, Preschool; China; Chlorogenic Acid; Chloroquine; Chromatography, Gas; Chronic Disease; Clinical Competence; Coated Materials, Biocompatible; Cochlea; Cohort Studies; Color; Comorbidity; Computer Simulation; Computer-Aided Design; Contraception; Contraceptive Agents, Female; Contrast Media; COP-Coated Vesicles; Coronavirus Infections; Cost of Illness; Coturnix; COVID-19; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Culex; Curriculum; Cyclic N-Oxides; Cytokines; Cytoplasm; Cytotoxicity, Immunologic; Cytotoxins; Databases, Factual; Deep Learning; Delivery, Obstetric; Denitrification; Dental Caries; Denture, Complete; Dexamethasone; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dielectric Spectroscopy; Diet, High-Fat; Dietary Fiber; Disease Models, Animal; Disease Progression; DNA; DNA Copy Number Variations; DNA, Mitochondrial; Dog Diseases; Dogs; Dopaminergic Neurons; Double-Blind Method; Down-Regulation; Doxorubicin; Drug Carriers; Drug Design; Drug Interactions; Drug Resistance, Bacterial; Drug Resistance, Neoplasm; Drug-Related Side Effects and Adverse Reactions; Drugs, Chinese Herbal; Dry Powder Inhalers; Dust; E2F1 Transcription Factor; Ecosystem; Education, Nursing; Education, Nursing, Baccalaureate; Electric Impedance; Electricity; Electrocardiography; Electrochemical Techniques; Electrochemistry; Electrodes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Endothelial Cells; Environmental Monitoring; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Estrogen Receptor Modulators; Europe; Evoked Potentials, Auditory, Brain Stem; Exosomes; Feasibility Studies; Female; Ferricyanides; Ferrocyanides; Fibrinogen; Finite Element Analysis; Fistula; Fluorescent Dyes; Fluorides, Topical; Fluorodeoxyglucose F18; Fluticasone; Follow-Up Studies; Food Contamination; Food Microbiology; Foods, Specialized; Forensic Medicine; Frail Elderly; France; Free Radicals; Fresh Water; Fungi; Fungicides, Industrial; Galactosamine; Gastrointestinal Neoplasms; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Frequency; Genetic Predisposition to Disease; Genotype; Gingival Hemorrhage; Glioblastoma; Glioma; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Glucose; Glucose Transport Proteins, Facilitative; Glucosides; Glutamine; Glycolysis; Gold; GPI-Linked Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Graphite; Haplotypes; HCT116 Cells; Healthy Volunteers; Hearing Loss; Heart Failure; Hedgehog Proteins; HEK293 Cells; HeLa Cells; Hemodynamics; Hemorrhage; Hepatocytes; Hippo Signaling Pathway; Histone Deacetylases; Homeostasis; Hospital Mortality; Hospitalization; Humans; Hydantoins; Hydrazines; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Hydroxylamines; Hypoglycemic Agents; Immunity, Innate; Immunoglobulin G; Immunohistochemistry; Immunologic Factors; Immunomodulation; Immunophenotyping; Immunotherapy; Incidence; Indazoles; Indonesia; Infant; Infant, Newborn; Infarction, Middle Cerebral Artery; Inflammation; Injections, Intramuscular; Insecticides; Insulin-Like Growth Factor I; Insurance, Health; Intention to Treat Analysis; Interleukin-1 Receptor-Associated Kinases; Interleukin-6; Intrauterine Devices; Intrauterine Devices, Copper; Iron; Ischemia; Jordan; Keratinocytes; Kidney; Kidney Diseases; Kir5.1 Channel; Klebsiella Infections; Klebsiella pneumoniae; Lab-On-A-Chip Devices; Laparoscopy; Lasers; Lasers, Semiconductor; Lenalidomide; Leptin; Lethal Dose 50; Levonorgestrel; Limit of Detection; Lipid Metabolism; Lipid Metabolism Disorders; Lipogenesis; Lipopolysaccharides; Liquid Biopsy; Liver; Liver Abscess, Pyogenic; Liver Cirrhosis; Liver Diseases; Liver Neoplasms; Longevity; Lung Neoplasms; Luteolin; Lymph Nodes; Lymphocyte Activation; Macaca fascicularis; Macrophages; Mad2 Proteins; Magnetic Resonance Imaging; Male; Mammary Glands, Human; Manganese; Manganese Compounds; MAP Kinase Signaling System; Materials Testing; Maternal Health Services; MCF-7 Cells; Medicaid; Medicine, Chinese Traditional; Melanoma; Membrane Proteins; Mental Health; Mercury; Metal Nanoparticles; Metals, Heavy; Metformin; Methionine Adenosyltransferase; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Nude; Microalgae; Microbial Sensitivity Tests; Microglia; MicroRNAs; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Middle Aged; Mitochondria; Mitochondrial Proteins; Mitral Valve; Mitral Valve Insufficiency; Models, Anatomic; Molecular Structure; Molybdenum; Monocarboxylic Acid Transporters; Moths; MPTP Poisoning; Multigene Family; Multiparametric Magnetic Resonance Imaging; Multiple Myeloma; Muscle, Skeletal; Mutagens; Mutation; Myeloid Cells; Nanocomposites; Nanofibers; Nanomedicine; Nanoparticles; Nanowires; Neoadjuvant Therapy; Neomycin; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasms; Neoplastic Stem Cells; Neostriatum; Neovascularization, Pathologic; Netherlands; Neuromuscular Agents; Neurons; NF-E2-Related Factor 2; NF-kappa B; Nickel; Nitrogen Oxides; Non-alcoholic Fatty Liver Disease; Nucleosides; Nucleotidyltransferases; Nutritional Status; Obesity, Morbid; Ofloxacin; Oils, Volatile; Oligopeptides; Oncogene Protein v-akt; Optical Imaging; Organic Cation Transport Proteins; Organophosphonates; Osteoarthritis; Osteoarthritis, Hip; Osteoarthritis, Knee; Osteoblasts; Osteogenesis; Oxidation-Reduction; Oxidative Stress; Oxides; Oxygen Isotopes; Pancreas; Pancreaticoduodenectomy; Pandemics; Particle Size; Particulate Matter; Patient Acceptance of Health Care; Patient Compliance; PC-3 Cells; Peptide Fragments; Peptides; Periodontal Attachment Loss; Periodontal Index; Periodontal Pocket; Periodontitis; Peroxides; Peru; Pest Control, Biological; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phylogeny; Pilot Projects; Piperidines; Plant Bark; Plant Extracts; Plant Leaves; Plasmids; Platelet Function Tests; Pneumonia, Viral; Podocytes; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Terephthalates; Polymers; Polymorphism, Single Nucleotide; Porosity; Portugal; Positron-Emission Tomography; Postoperative Complications; Postural Balance; Potassium Channels, Inwardly Rectifying; Povidone; Powders; Precancerous Conditions; Precision Medicine; Predictive Value of Tests; Pregnancy; Prenatal Care; Prognosis; Promoter Regions, Genetic; Prospective Studies; Prostatectomy; Prostatic Neoplasms; Proteasome Inhibitors; Protective Agents; Protein Binding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-akt; Psychiatric Nursing; PTEN Phosphohydrolase; Pulmonary Embolism; Pyrimethamine; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Rats, Wistar; Reactive Oxygen Species; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; Receptors, G-Protein-Coupled; Recombinational DNA Repair; Recovery of Function; Regional Blood Flow; Renal Dialysis; Renin; Renin-Angiotensin System; Reperfusion Injury; Reproducibility of Results; Republic of Korea; Respiratory Distress Syndrome; Retrospective Studies; Rhodamines; Risk Assessment; Risk Factors; RNA, Long Noncoding; RNA, Messenger; Running; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salinity; Salmeterol Xinafoate; Sarcoma; Seasons; Shoulder Injuries; Signal Transduction; Silicon Dioxide; Silver; Sirtuin 1; Sirtuins; Skull Fractures; Social Determinants of Health; Sodium; Sodium Fluoride; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Glucose Transporter 2 Inhibitors; Soil; Soil Pollutants; Spain; Spectrophotometry; Spectroscopy, Fourier Transform Infrared; Staphylococcal Protein A; Staphylococcus aureus; Stem Cells; Stereoisomerism; Stomach Neoplasms; Streptomyces; Strontium; Structure-Activity Relationship; Students, Nursing; Substance-Related Disorders; Succinic Acid; Sulfur; Surface Properties; Survival Rate; Survivin; Symporters; T-Lymphocytes; Temozolomide; Tensile Strength; Thiazoles; Thiobacillus; Thiohydantoins; Thiourea; Thrombectomy; Time Factors; Titanium; Tobacco Mosaic Virus; Tobacco Use Disorder; Toll-Like Receptor 4; Toluene; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Toxicity Tests, Acute; Toxicity Tests, Subacute; Transcriptional Activation; Treatment Outcome; Troponin I; Tumor Cells, Cultured; Tumor Escape; Tumor Hypoxia; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Tyrosine; Ubiquitin-Protein Ligases; Ubiquitination; Ultrasonic Waves; United Kingdom; United States; United States Department of Veterans Affairs; Up-Regulation; Urea; Uric Acid; Urinary Bladder Neoplasms; Urinary Bladder, Neurogenic; Urine; Urodynamics; User-Computer Interface; Vemurafenib; Verbenaceae; Veterans; Veterans Health; Viral Load; Virtual Reality; Vitiligo; Water Pollutants, Chemical; Wildfires; Wnt Signaling Pathway; Wound Healing; X-Ray Diffraction; Xenograft Model Antitumor Assays; Xylenes; Young Adult; Zinc; Zinc Oxide; Zinc Sulfate; Zoonoses | 2021 |
FDA Approval Summary: Alpelisib Plus Fulvestrant for Patients with HR-positive, HER2-negative, PIK3CA-mutated, Advanced or Metastatic Breast Cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Double-Blind Method; Drug Approval; Female; Fulvestrant; Humans; Male; Middle Aged; Mutation; Neoplasm Metastasis; Patient Reported Outcome Measures; Receptor, ErbB-2; Receptors, Estrogen; Thiazoles | 2021 |
Alpelisib plus fulvestrant for PIK3CA-mutated, hormone receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: final overall survival results from SOLAR-1.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Fulvestrant; Humans; Male; Receptor, ErbB-2; Receptors, Estrogen; Thiazoles | 2021 |
Alpelisib Plus Letrozole Shows Promise After CDK 4/6 Inhibitor Therapy in PIK3CA-Mutated HR+/HER2- Advanced Breast Cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Female; Humans; Letrozole; Receptor, ErbB-2; Thiazoles | 2021 |
Alpelisib plus fulvestrant in PIK3CA-mutated, hormone receptor-positive advanced breast cancer after a CDK4/6 inhibitor (BYLieve): one cohort of a phase 2, multicentre, open-label, non-comparative study.
Topics: Adolescent; Adult; Aged; Aromatase Inhibitors; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Estrogen Receptor Antagonists; Female; Fulvestrant; Humans; Middle Aged; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Thiazoles | 2021 |
Effectiveness of Alpelisib + Fulvestrant Compared with Real-World Standard Treatment Among Patients with HR+, HER2-, PIK3CA-Mutated Breast Cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Fulvestrant; Humans; Receptor, ErbB-2; Receptors, Estrogen; Thiazoles | 2021 |
A Phase I Study of Alpelisib in Combination with Trastuzumab and LJM716 in Patients with
Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Humans; Middle Aged; Mutation; Neoplasm Metastasis; Receptor, ErbB-2; Thiazoles; Trastuzumab | 2021 |
Potential for Long-Term Disease Control with Alpelisib Plus Fulvestrant Spans Patient Subgroups in HR+ PIK3CA-Mutated Advanced Breast Cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Fulvestrant; Humans; Receptor, ErbB-2; Thiazoles | 2021 |
Phosphatidylinositol 3-Kinase α-Selective Inhibition With Alpelisib (BYL719) in PIK3CA-Altered Solid Tumors: Results From the First-in-Human Study.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Middle Aged; Thiazoles; Treatment Outcome | 2018 |
Phase I study of alpelisib (BYL-719) and trastuzumab emtansine (T-DM1) in HER2-positive metastatic breast cancer (MBC) after trastuzumab and taxane therapy.
Topics: Ado-Trastuzumab Emtansine; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Bridged-Ring Compounds; Female; Humans; Kaplan-Meier Estimate; Maximum Tolerated Dose; Maytansine; Middle Aged; Neoplasm Staging; Phosphatidylinositol 3-Kinases; Receptor, ErbB-2; Retreatment; Taxoids; Thiazoles; Trastuzumab; Treatment Outcome | 2018 |
Alpelisib Plus Fulvestrant in PIK3CA-Altered and PIK3CA-Wild-Type Estrogen Receptor-Positive Advanced Breast Cancer: A Phase 1b Clinical Trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Disease Progression; Estrogen Receptor Antagonists; Female; Fulvestrant; Humans; Maximum Tolerated Dose; Middle Aged; Mutation; Progression-Free Survival; Protein Kinase Inhibitors; Receptors, Estrogen; Thiazoles; Time Factors | 2019 |
Alpelisib for
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Diarrhea; Female; Fulvestrant; Humans; Male; Middle Aged; Mutation; Progression-Free Survival; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Thiazoles | 2019 |
Dasatinib plus capecitabine for advanced breast cancer: safety and efficacy in phase I study CA180004.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Breast Neoplasms; Capecitabine; Dasatinib; Deoxycytidine; Female; Fluorouracil; Humans; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Pyrimidines; Thiazoles; Treatment Outcome | 2013 |
Gene signature-guided dasatinib therapy in metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Biopsy; Breast Neoplasms; Dasatinib; Female; Gene Expression Profiling; Humans; Middle Aged; Neoplasm Metastasis; Protein Kinase Inhibitors; Pyrimidines; Risk Factors; src-Family Kinases; Thiazoles; Transcriptome; Treatment Outcome | 2014 |
LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer.
Topics: Amino Acid Substitution; Aminopyridines; Animals; Breast Neoplasms; Dasatinib; Drug Resistance, Neoplasm; Drug Synergism; Estrogen Receptor Modulators; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Morpholines; Mutation, Missense; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Receptors, Estrogen; src Homology Domains; src-Family Kinases; Thiazoles; Xenograft Model Antitumor Assays | 2014 |
Preventive Analgesic Efficacy of Nefopam in Acute and Chronic Pain After Breast Cancer Surgery: A Prospective, Double-Blind, and Randomized Trial.
Topics: Acute Pain; Adult; Aged; Analgesics, Non-Narcotic; Axilla; Breast Neoplasms; Chemoradiotherapy, Adjuvant; Chronic Pain; Cyclooxygenase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Ketorolac; Mastectomy, Segmental; Meloxicam; Middle Aged; Nefopam; Pain Measurement; Pain, Postoperative; Preoperative Care; Prospective Studies; Sentinel Lymph Node Biopsy; Thiazines; Thiazoles | 2016 |
A phase I study of dasatinib and weekly paclitaxel for metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Breast Neoplasms, Male; Dasatinib; Edema; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Paclitaxel; Pleural Effusion, Malignant; Pyrimidines; Thiazoles; Treatment Outcome | 2011 |
Phase II trial of dasatinib in patients with metastatic breast cancer using real-time pharmacodynamic tissue biomarkers of Src inhibition to escalate dosing.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Dasatinib; Female; Humans; Kaplan-Meier Estimate; Middle Aged; Neoplasm Metastasis; Protein Kinase Inhibitors; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Thiazoles | 2011 |
A phase 2 trial of dasatinib in patients with advanced HER2-positive and/or hormone receptor-positive breast cancer.
Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Dasatinib; Female; Humans; Middle Aged; Protein Kinase Inhibitors; Pyrimidines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; src-Family Kinases; Thiazoles | 2011 |
Efficacy of meloxicam in combination with preoperative chemotherapy for breast cancer - Japan Breast Cancer Research Network (JBCRN) 02-1 trial.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Combined Modality Therapy; Cyclooxygenase Inhibitors; Female; Humans; Japan; Logistic Models; Meloxicam; Middle Aged; Nervous System Diseases; Preoperative Care; Thiazines; Thiazoles; Treatment Outcome; Young Adult | 2011 |
Incremental increase in VEGFR1⁺ hematopoietic progenitor cells and VEGFR2⁺ endothelial progenitor cells predicts relapse and lack of tumor response in breast cancer patients.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Biomarkers, Tumor; Breast Neoplasms; Cell Count; Cohort Studies; Dasatinib; Female; Hemangioblasts; Hematopoietic Stem Cells; Humans; Lapatinib; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Pyrimidines; Quinazolines; Thiazoles; Trastuzumab; Vascular Endothelial Growth Factor Receptor-1; Vascular Endothelial Growth Factor Receptor-2 | 2012 |
Use of the peroxisome proliferator-activated receptor (PPAR) gamma ligand troglitazone as treatment for refractory breast cancer: a phase II study.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Chromans; Disease Progression; Female; Humans; Liver; Middle Aged; Neoplasm Invasiveness; Thiazoles; Thiazolidinediones; Treatment Outcome; Troglitazone | 2003 |
324 other study(ies) available for thiazoles and Breast Neoplasms
Article | Year |
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Camalexin, an indole phytoalexin, inhibits cell proliferation, migration, and mammosphere formation in breast cancer cells via the aryl hydrocarbon receptor.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Indoles; Phytoalexins; Receptors, Aryl Hydrocarbon; Sesquiterpenes; Thiazoles | 2022 |
Design and development of novel fasudil derivatives as potent antibreast cancer agent that improves intestinal flora and intestinal barrier function in rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antineoplastic Agents; Breast Neoplasms; Colon; Drug Screening Assays, Antitumor; Female; Gastrointestinal Microbiome; Humans; Lipid Peroxidation; Mammary Neoplasms, Experimental; MCF-7 Cells; Rats, Sprague-Dawley; rho-Associated Kinases; Thiazoles | 2021 |
Sensitive and robust liquid biopsy-based detection of PIK3CA mutations in hormone-receptor-positive metastatic breast cancer patients.
Topics: Breast Neoplasms; Circulating Tumor DNA; Class I Phosphatidylinositol 3-Kinases; Estrogen Receptor alpha; Female; High-Throughput Nucleotide Sequencing; Humans; Liquid Biopsy; Mutation; Neoplasm Metastasis; Receptors, Progesterone; Thiazoles | 2022 |
Adverse events of alpelisib: A postmarketing study of the World Health Organization pharmacovigilance database.
Topics: Adverse Drug Reaction Reporting Systems; Breast Neoplasms; Databases, Factual; Diarrhea; Drug-Related Side Effects and Adverse Reactions; Exanthema; Female; Humans; Hyperglycemia; Pharmacovigilance; Thiazoles; World Health Organization | 2022 |
Factors leading to alpelisib discontinuation in patients with hormone receptor positive, human epidermal growth factor receptor-2 negative breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Middle Aged; Receptor, ErbB-2; Receptors, Estrogen; Thiazoles; Triple Negative Breast Neoplasms | 2022 |
Alpelisib Plus Fulvestrant or Letrozole Demonstrates Sustained Benefits Across Subgroups of Patients with PIK3CA-Mutated HR+/HER2- Advanced Breast Cancer.
Topics: Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Fulvestrant; Humans; Letrozole; Thiazoles | 2022 |
Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; Lung Neoplasms; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Structure-Activity Relationship; Thiazoles | 2022 |
Androgen and oestrogen receptor co-expression determines the efficacy of hormone receptor-mediated radiosensitisation in breast cancer.
Topics: Androgen Receptor Antagonists; Androgens; Breast Neoplasms; Cell Line, Tumor; Estrogen Receptor Antagonists; Female; Fulvestrant; Humans; Naphthalenes; Piperidines; Pyrrolidines; Radiation Tolerance; Receptors, Androgen; Receptors, Estrogen; Tamoxifen; Thiazoles; Triazoles | 2022 |
A PIK3CA-mutant breast cancer metastatic patient-derived organoid approach to evaluate alpelisib treatment for multiple secondary lesions.
Topics: Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Humans; Mutation; Organoids; Thiazoles | 2022 |
Fatostatin inhibits SREBP2-mediated cholesterol uptake via LDLR against selective estrogen receptor α modulator-induced hepatic lipid accumulation.
Topics: Breast Neoplasms; Cholesterol; Estrogen Receptor alpha; Female; Humans; Liver; Non-alcoholic Fatty Liver Disease; Pyridines; Receptors, LDL; Selective Estrogen Receptor Modulators; Sterol Regulatory Element Binding Protein 2; Tamoxifen; Thiazoles | 2022 |
Synthesis and Biological Evaluation of Thiazole-Based Derivatives with Potential against Breast Cancer and Antimicrobial Agents.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Microbial Sensitivity Tests; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2022 |
Alpelisib for PIK3CA-Mutated Advanced Breast Cancer.
Topics: Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Humans; Thiazoles | 2019 |
Alpelisib for PIK3CA-Mutated Advanced Breast Cancer.
Topics: Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Humans; Thiazoles | 2019 |
Alpelisib for PIK3CA-Mutated Advanced Breast Cancer. Reply.
Topics: Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Humans; Thiazoles | 2019 |
Precision medicine: PI3K targeting in advanced breast cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Fulvestrant; Humans; Molecular Targeted Therapy; Mutation; Phosphoinositide-3 Kinase Inhibitors; Precision Medicine; PTEN Phosphohydrolase; Thiazoles | 2019 |
New Drug for Breast Cancer with Specific Genetic Mutations.
Topics: Adult; Breast Neoplasms; Female; Humans; Middle Aged; Mutation; Thiazoles | 2019 |
Double
Topics: Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Class Ia Phosphatidylinositol 3-Kinase; Drug Resistance, Neoplasm; Female; Humans; Mutation; Neoplasms; Phosphoinositide-3 Kinase Inhibitors; Protein Binding; Protein Domains; Thiazoles | 2019 |
Proteomic Level Changes on Treatment in MCF-7/DDP Breast Cancer Drug- Resistant Cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Caspase Inhibitors; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Humans; MCF-7 Cells; Proteomics; Signal Transduction; Thiazoles | 2020 |
Novel breast cancer treatment leads to hyperglycaemia.
Topics: Aged; Antineoplastic Agents, Hormonal; Blood Glucose; Blood Glucose Self-Monitoring; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Fulvestrant; Humans; Hyperglycemia; Monitoring, Ambulatory; Phosphoinositide-3 Kinase Inhibitors; Prediabetic State; Thiazoles | 2020 |
Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation.
Topics: Breast Neoplasms; Cannabinoids; Cyclooxygenase 2; Female; Gene Expression; Humans; PPAR delta; Signal Transduction; Sulfones; Thiazoles; Thiophenes; Transcription Factor AP-1; Tumor Cells, Cultured | 2020 |
Frequency and spectrum of PIK3CA somatic mutations in breast cancer.
Topics: Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Cohort Studies; Databases, Genetic; Disease-Free Survival; Female; Genetic Testing; Humans; Molecular Targeted Therapy; Mutation; Predictive Value of Tests; Thiazoles | 2020 |
The MyD88 inhibitor TJ-M2010-2 suppresses proliferation, migration and invasion of breast cancer cells by regulating MyD88/GSK-3β and MyD88/NF-κB signalling pathways.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cytokines; Down-Regulation; Epithelial-Mesenchymal Transition; Female; Glycogen Synthase Kinase 3 beta; Humans; Lipopolysaccharides; Macrophages; Mice, Inbred BALB C; Mice, Nude; Myeloid Differentiation Factor 88; Neoplasm Invasiveness; Neoplasm Proteins; Neovascularization, Pathologic; NF-kappa B; Piperazines; Signal Transduction; Thiazoles; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2020 |
Dermatologic adverse events related to the PI3Kα inhibitor alpelisib (BYL719) in patients with breast cancer.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents; Antineoplastic Agents; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Dose-Response Relationship, Drug; Drug Eruptions; Eosinophilia; Exanthema; Female; Histamine Antagonists; Humans; Middle Aged; Neoplasm Proteins; Protein Kinase Inhibitors; Randomized Controlled Trials as Topic; Retrospective Studies; Thiazoles | 2020 |
A Phase Ib Study of Alpelisib or Buparlisib Combined with Tamoxifen Plus Goserelin in Premenopausal Women with HR-Positive HER2-Negative Advanced Breast Cancer.
Topics: Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclin-Dependent Kinase 4; Female; Goserelin; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Receptor, ErbB-2; Tamoxifen; Thiazoles | 2021 |
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors.
Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Breast Neoplasms; Cell Proliferation; Drug Screening Assays, Antitumor; ErbB Receptors; Erlotinib Hydrochloride; Female; Humans; MCF-7 Cells; Molecular Docking Simulation; Protein Kinase Inhibitors; Quantitative Structure-Activity Relationship; Thiazoles | 2020 |
Combined LIM kinase 1 and p21-Activated kinase 4 inhibitor treatment exhibits potent preclinical antitumor efficacy in breast cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Lim Kinases; MAP Kinase Signaling System; Mice; p21-Activated Kinases; Phosphorylation; Pyrazoles; Pyrroles; Thiazoles; Xenograft Model Antitumor Assays | 2020 |
Phase Ib Study of Ribociclib plus Fulvestrant and Ribociclib plus Fulvestrant plus PI3K Inhibitor (Alpelisib or Buparlisib) for HR
Topics: Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclin-Dependent Kinase 4; Female; Fulvestrant; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Purines; Receptors, Estrogen; Thiazoles | 2021 |
Fatostatin in Combination with Tamoxifen Induces Synergistic Inhibition in ER-Positive Breast Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Injections, Intraperitoneal; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Pyridines; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Thiazoles | 2020 |
A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo.
Topics: Androgen Receptor Antagonists; Animals; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Mice; Mice, SCID; Piperidines; Proteolysis; Pyrrolidines; Receptors, Androgen; Thiazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
[New European approvals: Alpelisib for HRpos/HER2neg metastatic breast cancer with PIK3CA mutation].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Ductal, Breast; Class I Phosphatidylinositol 3-Kinases; Clinical Trials as Topic; Drug Approval; Drug Resistance, Neoplasm; Estrogens; Female; Fulvestrant; Humans; Male; Multicenter Studies as Topic; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Progesterone; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; Thiazoles | 2020 |
Paper-supported co-culture system for dynamic investigations of the lung-tropic migration of breast cancer cells.
Topics: Breast Neoplasms; Cancer-Associated Fibroblasts; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Cell Survival; Coculture Techniques; Disease Progression; Epithelial-Mesenchymal Transition; Female; Fibroblasts; Humans; Lung; Lung Neoplasms; Microscopy, Fluorescence; Neoplasm Invasiveness; Neoplasm Metastasis; Paper; Signal Transduction; Stromal Cells; Tetrazolium Salts; Thiazoles; Tumor Microenvironment | 2021 |
Setting the Pick: Can PI3K Inhibitors Circumvent CDK4/6 Inhibitor Resistance?
Topics: Aminopyridines; Breast Neoplasms; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Female; Goserelin; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Tamoxifen; Thiazoles | 2021 |
Avatrombopag Optimizes Response to Niraparib by Managing Thrombocytopenia Associated with Poly-ADP Ribose Polymerase (PARP) Inhibition in Ovarian Cancer and Breast Cancer: A Case Series.
Topics: Adenosine Diphosphate Ribose; Breast Neoplasms; Female; Humans; Indazoles; Ovarian Neoplasms; Piperidines; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Thiazoles; Thiophenes; Thrombocytopenia | 2020 |
Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer.
Topics: Aniline Compounds; Antineoplastic Combined Chemotherapy Protocols; Apoptosis Regulatory Proteins; Biopsy; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; Clinical Decision-Making; Drug Synergism; Female; Humans; Mastectomy; Mitochondrial Proteins; Necroptosis; Neoadjuvant Therapy; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thiazoles; Tyrosine-tRNA Ligase | 2020 |
SOLAR1s: alpelisib returns to earth?
Topics: Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; ErbB Receptors; Fulvestrant; Humans; Thiazoles | 2021 |
ESMO20 YO for YO: highlights on new drugs in advanced breast cancer focusing on sacituzumab govitecan and alpelisib.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Camptothecin; Female; Humans; Immunoconjugates; Thiazoles | 2021 |
Continuing Advancements in Breast Cancer Care.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Clinical Trials as Topic; Humans; Medical Oncology; Paclitaxel; Thiazoles | 2021 |
Nobiletin promotes the pyroptosis of breast cancer via regulation of miR-200b/JAZF1 axis.
Topics: Apoptosis; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Co-Repressor Proteins; DNA-Binding Proteins; Female; Flavones; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; MicroRNAs; NF-kappa B; Pyroptosis; Signal Transduction; Tetrazolium Salts; Thiazoles; Transfection | 2021 |
Alpelisib-induced hyperglycemia in older patients with breast Cancer: Qualitative findings.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Hyperglycemia; Thiazoles | 2021 |
Induction of interferon-β and interferon signaling by TRAIL and Smac mimetics via caspase-8 in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Caspase 8; Cell Line, Tumor; Female; Humans; Interferon-beta; MCF-7 Cells; Mitochondrial Proteins; Signal Transduction; Thiazoles; TNF-Related Apoptosis-Inducing Ligand | 2021 |
Analysis of genomic and non-genomic signaling of estrogen receptor in PDX models of breast cancer treated with a combination of the PI3K inhibitor alpelisib (BYL719) and fulvestrant.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Fulvestrant; Genomics; Humans; Mice; Middle Aged; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Prognosis; Proto-Oncogene Proteins pp60(c-src); Receptors, Estrogen; Signal Transduction; Thiazoles; Xenograft Model Antitumor Assays | 2021 |
Inhibition of the PI3K/mTOR Pathway in Breast Cancer to Enhance Response to Immune Checkpoint Inhibitors in Breast Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Female; Granulocytes; Humans; Immune Checkpoint Inhibitors; Mice; Mice, Inbred C57BL; Molecular Targeted Therapy; Morpholines; Paclitaxel; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Pyrimidines; Quinazolines; Thiazoles; TOR Serine-Threonine Kinases; Treatment Outcome; Triazines; Tumor Microenvironment; Xenograft Model Antitumor Assays | 2021 |
Cell Line-Specific Network Models of ER
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Class I Phosphatidylinositol 3-Kinases; Computer Simulation; Cyclin-Dependent Kinase Inhibitor p27; Drug Resistance, Neoplasm; Estrogen Receptor alpha; Female; Fulvestrant; HEK293 Cells; Humans; MCF-7 Cells; Models, Theoretical; Myeloid Cell Leukemia Sequence 1 Protein; Receptors, Estrogen; Retinoblastoma Binding Proteins; Signal Transduction; Thiazoles; Ubiquitin-Protein Ligases | 2021 |
Nanomolar potency of imidazo[2,1-b]thiazole analogs as indoleamine 2,3-dioxygenase inhibitors.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Female; Humans; Imidazoles; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inhibitory Concentration 50; Kidney Neoplasms; MCF-7 Cells; Models, Molecular; Structure-Activity Relationship; Thiazoles | 2021 |
ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-X Protein; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Synergism; Estrogen Receptor alpha; Everolimus; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Myeloid Cell Leukemia Sequence 1 Protein; Piperazines; Protein Isoforms; Proto-Oncogene Proteins c-akt; Pyridines; Pyrimidines; Signal Transduction; Sulfonamides; Thiazoles; Thiophenes | 2021 |
A Phase I Study of LSZ102, an Oral Selective Estrogen Receptor Degrader, with or without Ribociclib or Alpelisib, in Patients with Estrogen Receptor-Positive Breast Cancer.
Topics: Adult; Aminopyridines; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Purines; Receptors, Estrogen; Thiazoles; Thiophenes | 2021 |
Integration of Receptor Tyrosine Kinases Determines Sensitivity to PI3Kα-selective Inhibitors in Breast Cancer.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Disease Models, Animal; Drug Resistance; Female; Gene Expression Profiling; Heterografts; Humans; Mice, SCID; Protein-Tyrosine Kinases; Thiazoles; Treatment Failure | 2017 |
Downregulation of Bmi1 in breast cancer stem cells suppresses tumor growth and proliferation.
Topics: Animals; Apoptosis; Breast Neoplasms; Cell Proliferation; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Humans; Mice; Mice, Transgenic; Neoplastic Stem Cells; Polycomb Repressive Complex 1; Thiazoles; Tumor Cells, Cultured | 2017 |
Going beyond genetics to discover cancer targets.
Topics: Animals; Antineoplastic Agents; Atlases as Topic; Breast Neoplasms; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genome, Human; High-Throughput Nucleotide Sequencing; Humans; Mice; Molecular Targeted Therapy; Phosphatidylinositol 3-Kinase; Phosphoinositide-3 Kinase Inhibitors; Receptor, ErbB-2; Thiazoles; Xenograft Model Antitumor Assays | 2017 |
The reversion of anti-cancer drug antagonism of tamoxifen and docetaxel by the hyaluronic acid-decorated polymeric nanoparticles.
Topics: A549 Cells; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coumarins; Docetaxel; Female; Humans; Hyaluronic Acid; Male; MCF-7 Cells; Mice; Nanoparticles; Polymers; Tamoxifen; Taxoids; Thiazoles | 2017 |
Inhibition of the V-ATPase by Archazolid A: A New Strategy to Inhibit EMT.
Topics: Breast Neoplasms; Cadherins; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Macrolides; Neoplasm Metastasis; Neoplastic Stem Cells; Thiazoles; Vacuolar Proton-Translocating ATPases | 2017 |
Modulation of telomere protection by the PI3K/AKT pathway.
Topics: Aging; Animals; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; DNA Damage; Humans; Mice; Neoplasm Transplantation; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Stability; Proto-Oncogene Proteins c-akt; Telomere; Telomeric Repeat Binding Protein 1; Thiazoles | 2017 |
Analgesics promote welfare and sustain tumour growth in orthotopic 4T1 and B16 mouse cancer models.
Topics: Analgesics; Animal Welfare; Animals; Breast Neoplasms; Buprenorphine; Cell Line, Tumor; Disease Models, Animal; Female; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma, Experimental; Meloxicam; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Metastasis; Pain; Thiazines; Thiazoles; Xenograft Model Antitumor Assays | 2018 |
Synthesis and cytotoxicity evaluation of thiazole derivatives obtained from 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene- 3-carbonitrile.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cytotoxins; Hep G2 Cells; Humans; Liver Neoplasms; Nasopharyngeal Neoplasms; Stomach Neoplasms; Thiazoles | 2017 |
Albumin-covered lipid nanocapsules exhibit enhanced uptake performance by breast-tumor cells.
Topics: Breast Neoplasms; Cell Proliferation; Cell Survival; Coumarins; Curcumin; Drug Liberation; Endocytosis; Female; Humans; Lipids; MCF-7 Cells; Nanocapsules; Serum Albumin; Thiazoles | 2018 |
Inhibition of TACC3 by a small molecule inhibitor in breast cancer.
Topics: Apoptosis; Aurora Kinase A; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Microtubule-Associated Proteins; Neoplasm Proteins; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proteomics; Proto-Oncogene Proteins; Signal Transduction; Thiazoles | 2018 |
Development of Thiazole-5-carboxylate Derivatives as Selective Inhibitors of Monoacylglycerol Lipase as Target in Cancer.
Topics: Antineoplastic Agents; Arachidonic Acids; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Endocannabinoids; Enzyme Inhibitors; Female; Glycerides; Humans; Lung Neoplasms; Molecular Docking Simulation; Monoacylglycerol Lipases; Neoplasms; Structure-Activity Relationship; Thiazoles | 2019 |
Enhancing the Cancer Cell Growth Inhibitory Effects of Table Grape Anthocyanins.
Topics: Anthocyanins; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Caco-2 Cells; Catechol O-Methyltransferase; Catechol O-Methyltransferase Inhibitors; Catechols; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Female; Fruit; Glucosides; HT29 Cells; Humans; Methylation; Nitriles; Oxidative Stress; Phytotherapy; Plant Extracts; Tetrazolium Salts; Thiazoles; Vitis | 2018 |
Unexpected Benefit from Alpelisib and Fulvestrant in a Woman with Highly Pre-treated ER-Positive, HER2-Negative PIK3CA Mutant Metastatic Breast Cancer.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Female; Fulvestrant; Humans; Middle Aged; Mutation; Receptor, ErbB-2; Receptors, Estrogen; Thiazoles | 2018 |
Ligand-activated interaction of PPARδ with c-Myc governs the tumorigenicity of breast cancer.
Topics: A549 Cells; Animals; Breast Neoplasms; Carcinogenesis; Cell Line; Cell Line, Tumor; Cell Transformation, Neoplastic; Gene Expression Regulation, Neoplastic; HEK293 Cells; HeLa Cells; Humans; Ligands; MCF-7 Cells; PC12 Cells; PPAR delta; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Rats; RNA, Small Interfering; Thiazoles | 2018 |
Inhibition of BTF3 sensitizes luminal breast cancer cells to PI3Kα inhibition through the transcriptional regulation of ERα.
Topics: Animals; Breast Neoplasms; Cell Division; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Estrogen Receptor alpha; Female; G2 Phase; Gene Knockdown Techniques; Humans; MCF-7 Cells; Mice; Mice, Nude; Nuclear Proteins; Thiazoles; Transcription Factors; Transcription, Genetic; Xenograft Model Antitumor Assays | 2019 |
GPR119 agonist enhances gefitinib responsiveness through lactate-mediated inhibition of autophagy.
Topics: Animals; Autophagy; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; Female; Gefitinib; Humans; Lactic Acid; MCF-7 Cells; Mesylates; Mice, Inbred BALB C; Mice, Nude; Oxadiazoles; Receptors, G-Protein-Coupled; Tetrazoles; Thiazoles; Transfection | 2018 |
Crosstalks of the PTPIP51 interactome revealed in Her2 amplified breast cancer cells by the novel small molecule LDC3/Dynarrestin.
Topics: Breast Neoplasms; Calcium; Cell Line, Tumor; Cell Proliferation; CSK Tyrosine-Protein Kinase; Drug Interactions; Enzyme Activation; Homeostasis; Humans; Mitochondria; Mitochondrial Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NF-kappa B; Phosphorylation; Protein Interaction Maps; Protein Kinase Inhibitors; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-akt; Receptor, ErbB-2; Signal Transduction; Thiazoles | 2019 |
Tumor microenvironmental growth factors induce long-term estrogen deprivation resistance in breast cancer.
Topics: Aromatase Inhibitors; Breast Neoplasms; Cell Survival; Drug Resistance, Neoplasm; Epidermal Growth Factor; Estrogen Receptor alpha; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Receptor, ErbB-2; Thiazoles; Transfection; Tumor Microenvironment | 2019 |
Alpelisib effective in advanced-stage disease.
Topics: Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Humans; Thiazoles | 2019 |
Alpelisib plus fulvestrant for PIK3CA-mutated breast cancer.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Drug Combinations; Fulvestrant; Humans; Mutation; Thiazoles | 2019 |
Induction of Necroptosis in Human Breast Cancer Drug-Resistant Cells by SMAC Analog LCL161 After Caspase Inhibition Requires RIP3.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Gene Knockdown Techniques; Humans; MCF-7 Cells; Mitochondria; Necroptosis; Receptor-Interacting Protein Serine-Threonine Kinases; RNA, Small Interfering; Thiazoles | 2019 |
Trastuzumab-conjugated vitamin E TPGS liposomes for sustained and targeted delivery of docetaxel.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Area Under Curve; Breast Neoplasms; Calorimetry, Differential Scanning; Cell Line, Tumor; Cell Survival; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Coumarins; Docetaxel; Drug Carriers; Half-Life; Humans; Liposomes; Male; Microscopy, Confocal; Particle Size; Polyethylene Glycols; Rats, Sprague-Dawley; Receptor, ErbB-2; Spectroscopy, Fourier Transform Infrared; Taxoids; Thiazoles; Trastuzumab; Vitamin E | 2013 |
Unraveling the mechanisms behind the enhanced MTT conversion by irradiated breast cancer cells.
Topics: Breast Neoplasms; Cadherins; Cell Communication; Cell Count; Cell Line, Tumor; Female; Humans; Nitroblue Tetrazolium; Permeability; Tetrazolium Salts; Thiazoles | 2013 |
Cytotoxic effect of ethanol extract of microalga, Chaetoceros calcitrans, and its mechanisms in inducing apoptosis in human breast cancer cell line.
Topics: Annexin A5; Apoptosis; Biological Products; Breast Neoplasms; Cell Cycle; Cell Proliferation; Ethanol; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; MCF-7 Cells; Microalgae; Propidium; Regression Analysis; Tamoxifen; Tetrazolium Salts; Thiazoles | 2013 |
Dasatinib : a novel therapy for breast cancer?
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Movement; Clinical Trials as Topic; Dasatinib; Drug Evaluation, Preclinical; ErbB Receptors; Female; Humans; Protein Kinase Inhibitors; Pyrimidines; Signal Transduction; src-Family Kinases; Thiazoles | 2013 |
Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Caspases; Cell Cycle; Cell Line, Tumor; Cell Survival; Coloring Agents; Computer Simulation; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Drug Screening Assays, Antitumor; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; High-Throughput Screening Assays; Humans; Indicators and Reagents; Male; Models, Molecular; Phosphorylation; Structure-Activity Relationship; Testicular Neoplasms; Tetrazolium Salts; Thiazoles | 2013 |
Dasatinib inhibits mammary tumour development in a genetically engineered mouse model.
Topics: Administration, Oral; Animals; Antineoplastic Agents; beta Catenin; Breast Neoplasms; Cadherins; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dasatinib; Dose-Response Relationship, Drug; Drug Administration Schedule; Enhancer Elements, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Integrases; Lactoglobulins; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Neoplasm Invasiveness; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Pyrimidines; Signal Transduction; src-Family Kinases; Thiazoles; Time Factors | 2013 |
The nuclear import of oncoprotein hepatitis B X-interacting protein depends on interacting with c-Fos and phosphorylation of both proteins in breast cancer cells.
Topics: Active Transport, Cell Nucleus; Amino Acid Motifs; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Female; Humans; Microscopy, Confocal; Phosphorylation; Proto-Oncogene Proteins c-fos; RNA, Small Interfering; Serine; Tetrazolium Salts; Thiazoles; Trans-Activators; Viral Regulatory and Accessory Proteins | 2013 |
Docetaxel-loaded nanoparticles based on star-shaped mannitol-core PLGA-TPGS diblock copolymer for breast cancer therapy.
Topics: Antineoplastic Agents; Breast Neoplasms; Calorimetry, Differential Scanning; Cell Survival; Chromatography, Gel; Coumarins; Docetaxel; Female; Humans; Inhibitory Concentration 50; Lactic Acid; Magnetic Resonance Spectroscopy; Mannitol; MCF-7 Cells; Molecular Weight; Nanoparticles; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Static Electricity; Taxoids; Thermogravimetry; Thiazoles; Vitamin E; Xenograft Model Antitumor Assays | 2013 |
A c-Myc activation sensor-based high-throughput drug screening identifies an antineoplastic effect of nitazoxanide.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Drug Screening Assays, Antitumor; Female; Heterografts; High-Throughput Screening Assays; Humans; Mice; Mice, Nude; Molecular Imaging; Neoplasm Transplantation; Nitro Compounds; Proto-Oncogene Proteins c-myc; Thiazoles | 2013 |
CHL1 is involved in human breast tumorigenesis and progression.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Adhesion Molecules; Cell Line, Tumor; Cell Proliferation; Disease Progression; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mice; Mice, SCID; Neoplasm Invasiveness; Neoplasm Transplantation; RNA, Small Interfering; Tetrazolium Salts; Thiazoles | 2013 |
Folic acid conjugated δ-valerolactone-poly(ethylene glycol) based triblock copolymer as a promising carrier for targeted doxorubicin delivery.
Topics: Annexin A5; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Doxorubicin; Drug Carriers; Drug Screening Assays, Antitumor; Esters; Female; Folic Acid; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Micelles; Polyethylene Glycols; Pyrones; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Tetrazolium Salts; Thiazoles | 2013 |
Magnolol induces apoptosis in MCF-7 human breast cancer cells through G2/M phase arrest and caspase-independent pathway.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Inducing Factor; Biphenyl Compounds; Bisbenzimidazole; Breast Neoplasms; Caspases; Cell Division; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Cytochromes c; Female; Flow Cytometry; G2 Phase; Genes, bcl-2; Humans; Indicators and Reagents; Lignans; Membrane Potential, Mitochondrial; Mitochondria; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2013 |
Borrelidin has limited anti-cancer effects in bcl-2 overexpressing breast cancer and leukemia cells and reveals toxicity in non-malignant breast epithelial cells.
Topics: Adenosine Triphosphate; Antibiotics, Antineoplastic; Blotting, Western; Breast; Breast Neoplasms; Cell Line, Tumor; Epithelial Cells; Fatty Alcohols; Female; Genes, bcl-2; Human Umbilical Vein Endothelial Cells; Humans; Leukemia; Tetrazolium Salts; Thiazoles | 2014 |
A rationally designed photo-chemo core-shell nanomedicine for inhibiting the migration of metastatic breast cancer cells followed by photodynamic killing.
Topics: Breast; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Dasatinib; Drug Carriers; Female; Humans; Lactic Acid; Mesoporphyrins; Molecular Docking Simulation; Nanomedicine; Neoplasm Metastasis; Photochemotherapy; Photosensitizing Agents; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Protein-Tyrosine Kinases; Pyrimidines; Serum Albumin; Thiazoles | 2014 |
A novel liposomal nanomedicine for nitric oxide delivery and breast cancer treatment.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Delivery Systems; Drug Screening Assays, Antitumor; Female; Humans; Inhibitory Concentration 50; Lipids; Liposomes; Mannitol; Nanoparticles; Nitric Oxide; Pressure; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors | 2014 |
Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal.
Topics: Animals; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Disease Progression; Disease-Free Survival; Endothelial Cells; Erythropoietin; Female; Gene Expression Regulation; Humans; Hypoxia; Mammary Neoplasms, Experimental; Mice; Neoplasm Transplantation; Neoplastic Stem Cells; Recurrence; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors | 2014 |
Evaluating the potential bioactivity of a novel compound ER1626.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Movement; Cell Proliferation; Chick Embryo; Endometrial Neoplasms; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Human Umbilical Vein Endothelial Cells; Humans; Indenes; Isoquinolines; Ketones; MCF-7 Cells; Molecular Structure; Quinolones; Receptors, Estrogen; Tetrazolium Salts; Thiazoles | 2014 |
V-ATPase inhibition regulates anoikis resistance and metastasis of cancer cells.
Topics: Animals; Anoikis; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms, Experimental; Macrolides; Male; Mice; Mice, Inbred BALB C; Neoplasm Invasiveness; Signal Transduction; Thiazoles; Urinary Bladder Neoplasms | 2014 |
Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: The role of sphingosine 1-phosphate receptor
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; CSK Tyrosine-Protein Kinase; Female; Fingolimod Hydrochloride; Humans; Lysophospholipids; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Receptors, Estrogen; Receptors, Lysosphingolipid; RNA Interference; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; src-Family Kinases; Thiazoles; Tyrosine | 2014 |
Dasatinib-letrozole gets split verdict.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Dasatinib; Female; Humans; Letrozole; Nitriles; Protein Kinase Inhibitors; Pyrimidines; Receptor, ErbB-2; Receptors, Estrogen; Thiazoles; Treatment Outcome; Triazoles | 2014 |
Down-regulation of nicotinamide N-methyltransferase induces apoptosis in human breast cancer cells via the mitochondria-mediated pathway.
Topics: Animals; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cytochromes c; DNA Primers; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Mice; Mitochondria; Nicotinamide N-Methyltransferase; Reactive Oxygen Species; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Tetrazolium Salts; Thiazoles | 2014 |
Label-free fluorescent biosensor based on the target recycling and Thioflavin T-induced quadruplex formation for short DNA species of c-erbB-2 detection.
Topics: Base Pair Mismatch; Benzothiazoles; Biosensing Techniques; Breast Neoplasms; DNA; Female; Fluorescent Dyes; G-Quadruplexes; Humans; Nucleic Acid Amplification Techniques; Receptor, ErbB-2; Saliva; Thiazoles | 2014 |
Metabotropic glutamate receptor-1 as a novel target for the antiangiogenic treatment of breast cancer.
Topics: Animals; Benzimidazoles; Breast Neoplasms; Cell Line; Cell Proliferation; Endothelial Cells; Female; Humans; Immunohistochemistry; Mice; Mice, Inbred BALB C; Naphthalenes; Receptors, Metabotropic Glutamate; Thiazoles | 2014 |
Activity of a novel Hec1-targeted anticancer compound against breast cancer cell lines in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cytoskeletal Proteins; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 4 or More Rings; Humans; In Vitro Techniques; MCF-7 Cells; Mice; Molecular Targeted Therapy; Niacinamide; Nuclear Proteins; Thiazoles; Xenograft Model Antitumor Assays | 2014 |
Gold nanoparticles induce nuclear damage in breast cancer cells, which is further amplified by hyperthermia.
Topics: Breast Neoplasms; Cell Nucleus; Cell Proliferation; Cell Survival; Female; Fluorescent Dyes; Hot Temperature; Humans; Hyperthermia, Induced; MCF-7 Cells; Metal Nanoparticles; Microscopy, Confocal; Nanotechnology; Ribosomes; Tetrazolium Salts; Thiazoles | 2014 |
Targeting triple-negative breast cancer cells with 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Death; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Molecular Structure; Pyrroles; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2014 |
Synthesis of silver nanoparticles from Melia dubia leaf extract and their in vitro anticancer activity.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Chlorocebus aethiops; Female; Green Chemistry Technology; Humans; MCF-7 Cells; Melia; Metal Nanoparticles; Microscopy, Electron, Scanning; Plant Extracts; Plant Leaves; Silver; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Tetrazolium Salts; Thiazoles; Vero Cells; X-Ray Diffraction | 2014 |
The cyclin-dependent kinase inhibitor SNS-032 induces apoptosis in breast cancer cells via depletion of Mcl-1 and X-linked inhibitor of apoptosis protein and displays antitumor activity in vivo.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase 2; Female; Heterografts; Humans; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Real-Time Polymerase Chain Reaction; Thiazoles; X-Linked Inhibitor of Apoptosis Protein | 2014 |
Perfluorooctanoic acid stimulates breast cancer cells invasion and up-regulates matrix metalloproteinase-2/-9 expression mediated by activating NF-κB.
Topics: Blotting, Western; Breast Neoplasms; Caprylates; Cell Line, Tumor; Coloring Agents; Female; Fluorocarbons; Humans; Indicators and Reagents; Luciferases; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; NF-kappa B; Real-Time Polymerase Chain Reaction; RNA, Neoplasm; Tetrazolium Salts; Thiazoles; Transcriptional Activation; Up-Regulation | 2014 |
Targeting tyrosine-kinases and estrogen receptor abrogates resistance to endocrine therapy in breast cancer.
Topics: Acinar Cells; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Dasatinib; Drug Synergism; Estradiol; Estrogens; Female; Fulvestrant; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Receptor, IGF Type 1; Receptors, Estrogen; Signal Transduction; Thiazoles; Xenograft Model Antitumor Assays | 2014 |
Combined SFK/mTOR inhibition prevents rapamycin-induced feedback activation of AKT and elicits efficient tumor regression.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Dasatinib; Drug Resistance, Neoplasm; Female; Genes, src; Humans; MCF-7 Cells; Mice; Phosphorylation; Proto-Oncogene Proteins c-abl; Proto-Oncogene Proteins c-akt; Pyrimidines; Rats; Signal Transduction; Sirolimus; Thiazoles; TOR Serine-Threonine Kinases | 2014 |
Detection of increased 64Cu uptake by human copper transporter 1 gene overexpression using PET with 64CuCl2 in human breast cancer xenograft model.
Topics: Animals; Breast Neoplasms; Cation Transport Proteins; Cell Line, Tumor; Cisplatin; Copper; Copper Radioisotopes; Copper Transporter 1; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Kinetics; Mice; Positron-Emission Tomography; Tetrazolium Salts; Thiazoles; Xenograft Model Antitumor Assays | 2014 |
4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis.
Topics: Animals; Breast Neoplasms; Cell Proliferation; Female; Humans; Hydrazones; Mice; Neoplasm Metastasis; Neoplastic Stem Cells; Signal Transduction; Thiazoles | 2014 |
Cytotoxic constituents from the rhizomes of Curcuma zedoaria.
Topics: Analysis of Variance; Breast Neoplasms; Cell Proliferation; Chromatography, Thin Layer; Curcuma; Female; Human Umbilical Vein Endothelial Cells; Humans; Indonesia; Malaysia; MCF-7 Cells; Microscopy, Fluorescence; Molecular Structure; Phytotherapy; Plant Extracts; Rhizome; Tetrazolium Salts; Thiazoles | 2014 |
Significance of glioma-associated oncogene homolog 1 (GLI1) expression in claudin-low breast cancer and crosstalk with the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) pathway.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Claudins; Epithelial-Mesenchymal Transition; Female; Gene Expression; Heterocyclic Compounds, 2-Ring; Humans; Mice, Inbred NOD; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; NF-kappa B; Promoter Regions, Genetic; Protein Binding; Receptor Cross-Talk; RNA, Messenger; Signal Transduction; Thiazoles; Transcription Factors; Zinc Finger Protein GLI1 | 2014 |
Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor.
Topics: Alleles; Animals; Breast Neoplasms; Class I Phosphatidylinositol 3-Kinases; Drug Resistance, Neoplasm; Female; Humans; Loss of Heterozygosity; Mice; Mice, Nude; Phosphoinositide-3 Kinase Inhibitors; PTEN Phosphohydrolase; Thiazoles; Xenograft Model Antitumor Assays | 2015 |
Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer.
Topics: Animals; Blotting, Western; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Diphosphonates; Drug Repositioning; ErbB Receptors; Female; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Molecular Dynamics Simulation; Protein Binding; Signal Transduction; Tetrazolium Salts; Thiazoles; Tumor Stem Cell Assay | 2014 |
Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Dasatinib; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; MCF-7 Cells; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; RNA, Messenger; Thiazoles | 2015 |
Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Mice; Mice, Nude; Neoplasm Transplantation; ortho-Aminobenzoates; Pyrimidinones; Receptor, ErbB-2; Signal Transduction; Thiazoles | 2015 |
Breaking up is hard to do: PI3K isoforms on the rebound.
Topics: Aniline Compounds; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chromones; Class I Phosphatidylinositol 3-Kinases; Female; Humans; Neoplasms; ortho-Aminobenzoates; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; PTEN Phosphohydrolase; Pyrimidinones; Thiazoles | 2015 |
The synergistic inhibition of breast cancer proliferation by combined treatment with 4EGI-1 and MK2206.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Female; Heterocyclic Compounds, 3-Ring; Humans; Hydrazones; MCF-7 Cells; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Mice; Mice, Inbred BALB C; Mice, Nude; Multiprotein Complexes; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Proto-Oncogene Proteins c-akt; RNA, Small Interfering; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Transplantation, Heterologous | 2015 |
Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells.
Topics: Antineoplastic Agents; Apoptosis; Breast; Breast Neoplasms; Cell Line, Tumor; DNA Damage; Female; Gene Expression Regulation, Neoplastic; Humans; JNK Mitogen-Activated Protein Kinases; MCF-7 Cells; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Receptors, Aryl Hydrocarbon; Thiazoles | 2015 |
Potential antiproliferative effect of isoxazolo- and thiazolo coumarin derivatives on breast cancer mediated bone and lung metastases.
Topics: 4-Hydroxycoumarins; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Coumarins; Dose-Response Relationship, Drug; Female; Humans; Inhibitory Concentration 50; Isoxazoles; Lung Neoplasms; Thiazoles; Time Factors | 2015 |
Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells.
Topics: Angiogenesis Inhibitors; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Electron Transport Complex I; Female; Humans; Hypoxia-Inducible Factor 1; Inhibitory Concentration 50; Lipids; Mitochondria; Neovascularization, Pathologic; Signal Transduction; Thiazoles; Vascular Endothelial Growth Factor A | 2015 |
The Novel Ribonucleotide Reductase Inhibitor COH29 Inhibits DNA Repair In Vitro.
Topics: Animals; Antimetabolites, Antineoplastic; Benzamides; BRCA1 Protein; Breast Neoplasms; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Repair; Female; Heterografts; Humans; Mice, Inbred NOD; Mutagenicity Tests; Neoplasm Transplantation; Ribonucleotide Reductases; Thiazoles; Zebrafish | 2015 |
PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor-positive breast cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Endoplasmic Reticulum; Estrogen Receptor alpha; Female; Humans; MCF-7 Cells; Mice; Mice, Nude; Mutation; Neoplasm Metastasis; Neoplasm Transplantation; Oligonucleotide Array Sequence Analysis; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Research Design; Signal Transduction; Thiazoles | 2015 |
Exercise-induced changes in tumour LDH-B and MCT1 expression are modulated by oestrogen-related receptor alpha in breast cancer-bearing BALB/c mice.
Topics: Animals; Basigin; Breast Neoplasms; Cell Line, Tumor; ERRalpha Estrogen-Related Receptor; Female; Humans; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactic Acid; Mice, Inbred BALB C; Monocarboxylic Acid Transporters; Muscle Proteins; Nitriles; Physical Conditioning, Animal; Receptors, Estrogen; Symporters; Thiazoles; Tumor Burden | 2015 |
Synergistic antitumor activity of vitamin D3 combined with metformin in human breast carcinoma MDA-MB-231 cells involves m-TOR related signaling pathways.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cholecalciferol; Drug Synergism; Female; Humans; Hypoglycemic Agents; Metformin; Signal Transduction; Tetrazolium Salts; Thiazoles; TOR Serine-Threonine Kinases; Vitamins | 2015 |
Vacuolar-ATPase Inhibition Blocks Iron Metabolism to Mediate Therapeutic Effects in Breast Cancer.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Iron; Macrolides; MCF-7 Cells; Metabolic Networks and Pathways; Mice; Mice, Inbred BALB C; Thiazoles; Tumor Cells, Cultured; Vacuolar Proton-Translocating ATPases; Xenograft Model Antitumor Assays | 2015 |
Marketed Drugs Can Inhibit Cytochrome P450 27A1, a Potential New Target for Breast Cancer Adjuvant Therapy.
Topics: Adjuvants, Pharmaceutic; Anastrozole; Anilides; Animals; Antifungal Agents; Antineoplastic Agents; Breast Neoplasms; Cholestanetriol 26-Monooxygenase; Dexmedetomidine; Enzyme Inhibitors; Fadrozole; Female; Hypnotics and Sedatives; Mice; Mice, Inbred C57BL; Nitriles; Protein Binding; Thiazoles; Tosyl Compounds; Triazoles | 2015 |
Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells.
Topics: Acetylcarnitine; Breast Neoplasms; Cell Adhesion; Cell Proliferation; Cell Survival; Chromatography, Liquid; Doxycycline; ERRalpha Estrogen-Related Receptor; Forkhead Box Protein M1; Forkhead Transcription Factors; Glycolysis; Humans; MCF-7 Cells; Mitochondria; Neoplastic Stem Cells; Nitriles; Oligomycins; Organelle Biogenesis; Oxidative Phosphorylation; Proteomics; Receptors, Estrogen; Signal Transduction; Spheroids, Cellular; Tandem Mass Spectrometry; Thiazoles; Wnt Signaling Pathway | 2015 |
PI3K-p110α mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Class I Phosphatidylinositol 3-Kinases; Drug Resistance, Neoplasm; Female; Humans; Lapatinib; Mammary Neoplasms, Experimental; Mice, Knockout; Molecular Targeted Therapy; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Quinazolines; Receptor, ErbB-2; Signal Transduction; Thiazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Smac mimetic‑induced caspase‑independent necroptosis requires RIP1 in breast cancer.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Breast Neoplasms; Caspase Inhibitors; Caspases; Cell Proliferation; Female; Humans; Inhibitor of Apoptosis Proteins; MCF-7 Cells; Membrane Potential, Mitochondrial; Necrosis; Nuclear Pore Complex Proteins; Proteolysis; RNA-Binding Proteins; Thiazoles | 2016 |
Autophagy induction causes a synthetic lethal sensitization to ribonucleotide reductase inhibition in breast cancer cells.
Topics: Animals; Antimalarials; Antineoplastic Agents, Hormonal; Apoptosis; Autophagy; Benzamides; Blotting, Western; Breast Neoplasms; Cell Proliferation; Chloroquine; Drug Synergism; Drug Therapy, Combination; Female; Humans; Immunoenzyme Techniques; Mice; Mice, Inbred NOD; Mice, SCID; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleoside Diphosphate Reductase; RNA, Messenger; Tamoxifen; Thiazoles; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2016 |
Activation of IGF1R/p110β/AKT/mTOR confers resistance to α-specific PI3K inhibition.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Class Ia Phosphatidylinositol 3-Kinase; Drug Resistance, Neoplasm; Female; Humans; Insulin Receptor Substrate Proteins; Mice; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Receptors, Somatomedin; Thiazoles; TOR Serine-Threonine Kinases; Xenograft Model Antitumor Assays | 2016 |
Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines.
Topics: Antineoplastic Agents; Benzenesulfonamides; Breast Neoplasms; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Proliferation; Cell Survival; Drug Delivery Systems; Female; Humans; Inhibitory Concentration 50; MCF-7 Cells; Molecular Structure; Sulfonamides; Thiazoles | 2016 |
Novel quinolines carrying pyridine, thienopyridine, isoquinoline, thiazolidine, thiazole and thiophene moieties as potential anticancer agents.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Female; Humans; Inhibitory Concentration 50; Isoquinolines; MCF-7 Cells; Models, Molecular; Molecular Structure; Pyridines; Quinolines; Structure-Activity Relationship; Thiazoles; Thiazolidines; Thiophenes | 2016 |
Systematic Functional Characterization of Resistance to PI3K Inhibition in Breast Cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-pim-1; Thiazoles; Up-Regulation | 2016 |
Addition of the p110α inhibitor BYL719 overcomes targeted therapy resistance in cells from Her2-positive-PTEN-loss breast cancer.
Topics: Aminopyridines; Animals; Antibodies; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Female; Humans; Lapatinib; Mice; Morpholines; ortho-Aminobenzoates; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; PTEN Phosphohydrolase; Pyrimidinones; Quinazolines; Receptor, ErbB-2; Thiazoles; Xenograft Model Antitumor Assays | 2016 |
Enhanced Bioactivity of α-Tocopheryl Succinate Based Block Copolymer Nanoparticles by Reduced Hydrophobicity.
Topics: alpha-Tocopherol; Antioxidants; Biocompatible Materials; Breast Neoplasms; Coumarins; Drug Delivery Systems; Female; Humans; Hydrophobic and Hydrophilic Interactions; Methacrylates; Nanoparticles; Polyethylene Glycols; Polymerization; Polymers; Thiazoles; Tumor Cells, Cultured | 2016 |
GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment.
Topics: Animals; Benzamides; Bone Morphogenetic Protein Receptors; Breast Neoplasms; Cell Line, Tumor; Diamines; Dioxoles; Female; Gene Expression Regulation, Neoplastic; Glycosylation; Guanine Nucleotide Exchange Factors; Humans; Lung; Lung Neoplasms; Mice; Mice, Nude; Mutation; N-Acetylgalactosaminyltransferases; Neoplasms, Experimental; Polypeptide N-acetylgalactosaminyltransferase; Pyrazoles; Quinolines; Receptors, Notch; Receptors, Transforming Growth Factor beta; Thiazoles | 2016 |
α-Tocopherol as functional excipient for resveratrol and coenzyme Q10-loaded SNEDDS for improved bioavailability and prophylaxis of breast cancer.
Topics: Administration, Oral; alpha-Tocopherol; Animals; Antioxidants; Area Under Curve; Biological Availability; Breast Neoplasms; Caco-2 Cells; Coumarins; Drug Delivery Systems; Emulsions; Excipients; Female; Humans; Nanoparticles; Rats; Rats, Sprague-Dawley; Resveratrol; Stilbenes; Thiazoles; Ubiquinone | 2017 |
Acivicin with glutaminase regulates proliferation and invasion of human MCF-7 and OAW-42 cells--an in vitro study.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Collagen; Drug Combinations; Female; Glutaminase; Glutamine; Humans; In Vitro Techniques; Isoxazoles; Laminin; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Ovarian Neoplasms; Proteoglycans; Tetrazolium Salts; Thiazoles; Vascular Endothelial Growth Factor A | 2008 |
Dimethoxyaurones: Potent inhibitors of ABCG2 (breast cancer resistance protein).
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzofurans; Blotting, Western; Breast Neoplasms; Cell Proliferation; Cell Survival; Crystallography, X-Ray; DNA, Complementary; Dogs; Drug Resistance, Neoplasm; Female; Flow Cytometry; Fluoresceins; Humans; Indicators and Reagents; Mitoxantrone; Models, Molecular; Neoplasm Proteins; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2008 |
Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Fibroblast Growth Factors; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Glucuronidase; Humans; Insulin; Insulin-Like Growth Factor I; Ki-67 Antigen; Klotho Proteins; RNA, Small Interfering; Tetrazolium Salts; Thiazoles; Tissue Array Analysis | 2008 |
The Na+/K+-ATPase is the Achilles heel of multi-drug-resistant cancer cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cardenolides; Cell Line, Tumor; Cell Survival; Drug Resistance, Multiple; HeLa Cells; Humans; Hydroxyurea; Ligands; Neoplasms; Sodium-Potassium-Exchanging ATPase; Thiazoles | 2009 |
Cellular toxicity of nanogenomedicine in MCF-7 cell line: MTT assay.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Survival; Coloring Agents; Humans; Nanostructures; Spectrophotometry; Tetrazolium Salts; Thiazoles; Toxicity Tests | 2009 |
Induction of apoptosis by phloroglucinol derivative from Ecklonia Cava in MCF-7 human breast cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; Caspases; Cell Line, Tumor; Cell Proliferation; Coloring Agents; DNA Damage; Female; Gene Expression; Genes, bcl-2; Genes, p53; Humans; NF-kappa B; Phaeophyceae; Phloroglucinol; Plant Leaves; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Signal Transduction; Tetrazolium Salts; Thiazoles | 2009 |
MTT assays cannot be utilized to study the effects of STI571/Gleevec on the viability of solid tumor cell lines.
Topics: Antineoplastic Agents; Apoptosis; Benzamides; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Melanoma; Piperazines; Protein-Tyrosine Kinases; Pyrimidines; Tetrazolium Salts; Thiazoles | 2009 |
Water extract of Rheum officinale Baill. induces apoptosis in human lung adenocarcinoma A549 and human breast cancer MCF-7 cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Lung Neoplasms; Phytotherapy; Rheum; Tetrazolium Salts; Thiazoles | 2009 |
Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dasatinib; ErbB Receptors; Female; Humans; Protein Kinase Inhibitors; Pyrimidines; Signal Transduction; src-Family Kinases; Thiazoles | 2009 |
Synthesis and antitumoral activity of novel thiazolobenzotriazole, thiazoloindolo[3,2-c]quinoline and quinolinoquinoline derivatives.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases, Type I; Female; Humans; Indoles; Leukemia; Quinolines; Thiazoles; Topoisomerase I Inhibitors; Triazoles | 2009 |
Improvement in docetaxel-induced nail changes associated with cyclooxygenase-2 inhibitor treatment.
Topics: Antineoplastic Agents; Breast Neoplasms; Cyclooxygenase 2 Inhibitors; Docetaxel; Female; Humans; Meloxicam; Middle Aged; Nail Diseases; Taxoids; Thiazines; Thiazoles | 2009 |
Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells.
Topics: Actins; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Cytoskeleton; Dasatinib; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; G1 Phase; Humans; Neoplasm Invasiveness; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Thiazoles; Tubulin | 2009 |
Cytotoxicity and estrogenicity of Invisalign appliances.
Topics: Adenocarcinoma; Benzhydryl Compounds; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Coloring Agents; Dental Materials; Endocrine Disruptors; Estradiol; Estrogens, Non-Steroidal; Female; Fibroblasts; Gingiva; Humans; Materials Testing; Orthodontic Appliance Design; Phenols; Receptors, Estrogen; Sodium Chloride; Temperature; Tetrazolium Salts; Thiazoles; Time Factors; Tooth Movement Techniques | 2009 |
Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity.
Topics: Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Drug Design; Drug Screening Assays, Antitumor; Female; Humans; Indoles; Isatin; Thiazoles | 2009 |
SZ-685C, a marine anthraquinone, is a potent inducer of apoptosis with anticancer activity by suppression of the Akt/FOXO pathway.
Topics: Adenosine Diphosphate Ribose; Animals; Anthraquinones; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Breast Neoplasms; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Female; Humans; In Situ Nick-End Labeling; Liver Neoplasms; Male; Membrane Proteins; Mice; Mice, Nude; Phosphorylation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Tetrazolium Salts; Thiazoles | 2010 |
LYN is a mediator of epithelial-mesenchymal transition and a target of dasatinib in breast cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Dasatinib; Epithelial Cells; Female; Gene Expression Profiling; Humans; Mesoderm; Prognosis; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Thiazoles | 2010 |
Altered DNA methylation is associated with docetaxel resistance in human breast cancer cells.
Topics: Antineoplastic Agents; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Docetaxel; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Taxoids; Tetrazolium Salts; Thiazoles; Time Factors | 2010 |
Thiazole antibiotics against breast cancer.
Topics: Animals; Anti-Bacterial Agents; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Mice; Peptides; Thiazoles; Thiostrepton; Xenograft Model Antitumor Assays | 2010 |
Development of candidate genomic markers to select breast cancer patients for dasatinib therapy.
Topics: Antineoplastic Agents; Biomarkers, Pharmacological; Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Dasatinib; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Genome, Human; Humans; Matched-Pair Analysis; Oligonucleotide Array Sequence Analysis; Patient Selection; Prognosis; Pyrimidines; Thiazoles | 2010 |
miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1.
Topics: beta Catenin; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; High Mobility Group Proteins; Humans; MicroRNAs; Neoplasm Invasiveness; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Wnt Proteins | 2011 |
ErbB-inhibitory protein: a modified ectodomain of epidermal growth factor receptor synergizes with dasatinib to inhibit growth of breast cancer cells.
Topics: Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dasatinib; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; ErbB Receptors; Female; Humans; Immunohistochemistry; Mice; Mice, SCID; Protein Structure, Tertiary; Pyrimidines; Rats; Receptor, ErbB-2; Recombinant Fusion Proteins; Recombinant Proteins; Thiazoles; Xenograft Model Antitumor Assays | 2010 |
Induction of cell growth arrest and apoptotic cell death in human breast cancer MCF-7 cells by the COX-1 inhibitor FR122047.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma in Situ; Cell Death; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Drug Evaluation, Preclinical; Female; Humans; Isoxazoles; Piperazines; Sulfonamides; Thiazoles | 2010 |
Preparation and in-vitro/in-vivo evaluation of surface-modified poly (lactide-co-glycolide) fluorescent nanoparticles.
Topics: Animals; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Chitosan; Coumarins; Drug Carriers; Female; Flow Cytometry; Fluorescence; Lactic Acid; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Spectrometry, Fluorescence; Surface Properties; Technology, Pharmaceutical; Thiazoles; Tissue Distribution | 2010 |
Mo(II) complexes: a new family of cytotoxic agents?
Topics: 1-Octanol; Antineoplastic Agents; Breast Neoplasms; Cell Death; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; HeLa Cells; Humans; Inhibitory Concentration 50; Molecular Structure; Molybdenum; Neoplasms; Neuroblastoma; Nucleic Acid Conformation; Phenanthrolines; Tetrazolium Salts; Thiazoles; Water | 2010 |
Chiral 6-hydroxymethyl-1H,3H-pyrrolo[1,2-c]thiazoles: novel antitumor DNA monoalkylating agents.
Topics: Adenocarcinoma; Antineoplastic Agents, Alkylating; Breast Neoplasms; Cell Line, Tumor; Colorectal Neoplasms; DNA; Drug Screening Assays, Antitumor; Female; Humans; Melanoma; Pyrroles; Thiazoles | 2010 |
Effect of multikinase inhibitors on caspase-independent cell death and DNA damage in HER2-overexpressing breast cancer cells.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Caspases; Cell Line, Tumor; Dasatinib; DNA Damage; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Protein Kinase Inhibitors; Pyrimidines; Receptor, ErbB-2; Thiazoles; Trastuzumab; Up-Regulation | 2010 |
The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Densitometry; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Phosphotransferases (Alcohol Group Acceptor); Prostatic Neoplasms; Proteasome Endopeptidase Complex; Thiazoles; Ubiquitin | 2010 |
Preferential antitumor effect of the Src inhibitor dasatinib associated with a decreased proportion of aldehyde dehydrogenase 1-positive cells in breast cancer cells of the basal B subtype.
Topics: Aldehyde Dehydrogenase; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Dasatinib; DNA Damage; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Etoposide; Humans; Inhibitory Concentration 50; Neoplastic Stem Cells; Pyrimidines; src-Family Kinases; Thiazoles | 2010 |
Inhibition of the c-fms proto-oncogene autocrine loop and tumor phenotype in glucocorticoid stimulated human breast carcinoma cells.
Topics: Autocrine Communication; Breast Neoplasms; Carcinoma; Cell Adhesion; Cell Line, Tumor; Cell Movement; Dexamethasone; Dose-Response Relationship, Drug; Female; Glucocorticoids; Humans; Macrophage Colony-Stimulating Factor; Neoplasm Invasiveness; Oligonucleotides, Antisense; Phenotype; Phenylurea Compounds; Protein Kinase Inhibitors; Proto-Oncogene Mas; Receptor, Macrophage Colony-Stimulating Factor; RNA Interference; Thiazoles; Transfection | 2011 |
Anti-breast cancer activity of some novel 1,2-dihydropyridine, thiophene and thiazole derivatives.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Dihydropyridines; Humans; Inhibitory Concentration 50; Structure-Activity Relationship; Thiazoles; Thiophenes | 2011 |
Significance of ER-Src axis in hormonal therapy resistance.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Co-Repressor Proteins; Dasatinib; Drug Resistance, Neoplasm; Drug Synergism; Estrogen Receptor alpha; Female; Gene Knockdown Techniques; Humans; Letrozole; Mice; Mice, Nude; Mitogen-Activated Protein Kinases; Nitriles; Phosphorylation; Pyrimidines; Receptor, ErbB-2; RNA Interference; src-Family Kinases; Tamoxifen; Thiazoles; Transcription Factors; Triazoles; Tumor Burden; Xenograft Model Antitumor Assays | 2011 |
Pharmacological inhibition of sphingosine kinase isoforms alters estrogen receptor signaling in human breast cancer.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Computer Simulation; Estrogen Receptor alpha; Humans; Isoenzymes; Mass Spectrometry; Phosphotransferases (Alcohol Group Acceptor); Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiazoles | 2011 |
Src: a potential target for the treatment of triple-negative breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Cisplatin; Cytoplasm; Dasatinib; Female; Humans; Middle Aged; Molecular Targeted Therapy; Protein Kinase Inhibitors; Pyrimidines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; src-Family Kinases; Thiazoles | 2011 |
Changes in 2-fluoro-2-deoxy-D-glucose incorporation, hexokinase activity and lactate production by breast cancer cells responding to treatment with the anti-HER-2 antibody trastuzumab.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Fluorodeoxyglucose F18; Glucose; Hexokinase; Humans; Lactic Acid; Receptor, ErbB-2; Tetrazolium Salts; Thiazoles; Trastuzumab; Tumor Stem Cell Assay | 2011 |
Synthesis and biological activities of 2-amino-thiazole-5-carboxylic acid phenylamide derivatives.
Topics: Amides; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Combinatorial Chemistry Techniques; Dasatinib; Female; HT29 Cells; Humans; Inhibitory Concentration 50; Leukemia; Pyrimidines; Structure-Activity Relationship; Thiazoles | 2011 |
Simultaneous exposure of transformed cells to SRC family inhibitors and CHK1 inhibitors causes cell death.
Topics: Animals; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Benzimidazoles; Benzodioxoles; Breast Neoplasms; Cell Death; Cell Line, Transformed; Cell Transformation, Neoplastic; Checkpoint Kinase 1; Dasatinib; Female; Fibroblasts; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Mice; Protease Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-fyn; Proto-Oncogene Proteins c-yes; Pyrimidines; Quinazolines; Radiation Tolerance; src-Family Kinases; Thiazoles | 2011 |
Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Count; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colorimetry; Culture Media, Serum-Free; Deoxyuridine; DNA; Drug Design; Estradiol; Estrogens; Fingolimod Hydrochloride; Fluorescent Dyes; Fulvestrant; Humans; Isopropyl Thiogalactoside; Membrane Potential, Mitochondrial; Mitochondria; Propylene Glycols; Reproducibility of Results; Sphingosine; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p14ARF | 2011 |
Understanding the metabolic basis of drug resistance: therapeutic induction of the Warburg effect kills cancer cells.
Topics: Antineoplastic Agents, Hormonal; Apoptosis; Breast Neoplasms; Cell Line; Coculture Techniques; Dasatinib; Drug Resistance, Neoplasm; Female; Fibroblasts; Glycolysis; Humans; Pyrimidines; Tamoxifen; Telomerase; Thiazoles | 2011 |
Cellular imaging assay for early evaluation of an apoptosis inducer.
Topics: Annexin A5; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cytological Techniques; Female; Flow Cytometry; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Microscopy, Confocal; Phosphatidylserines; Staurosporine; Surface Plasmon Resonance; Tetrazolium Salts; Thiazoles | 2011 |
CYP2S1 and CYP2W1 mediate 2-(3,4-dimethoxyphenyl)-5-fluorobenzothiazole (GW-610, NSC 721648) sensitivity in breast and colorectal cancer cells.
Topics: Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Colorectal Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Enzyme Induction; Female; Humans; Male; Thiazoles | 2011 |
Thiazolyl N-benzyl-substituted acetamide derivatives: synthesis, Src kinase inhibitory and anticancer activities.
Topics: Acetamides; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Female; Humans; Inhibitory Concentration 50; Leukemia; Mice; Morpholines; NIH 3T3 Cells; Protein Kinase Inhibitors; Pyridines; src-Family Kinases; Structure-Activity Relationship; Thiazoles | 2011 |
Discovery of novel imidazo[1,2-a]pyrazin-8-amines as Brk/PTK6 inhibitors.
Topics: Adaptor Proteins, Signal Transducing; Animals; Aurora Kinases; Breast Neoplasms; Computer Simulation; Dasatinib; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Design; Drug Discovery; Drug Screening Assays, Antitumor; Female; Humans; Imidazoles; Inhibitory Concentration 50; Melanocytes; Mice; Molecular Targeted Therapy; Neoplasm Proteins; Oncogenes; Phenotype; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogenes; Pyrazines; Pyrimidines; RNA-Binding Proteins; Structure-Activity Relationship; Thiazoles | 2011 |
Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chromones; Dasatinib; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Immunoprecipitation; Metformin; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Pyrimidines; Receptor, ErbB-2; Receptor, IGF Type 1; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Trastuzumab | 2011 |
Anticancer and radio-sensitizing evaluation of some new thiazolopyrane and thiazolopyranopyrimidine derivatives bearing a sulfonamide moiety.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Drug Screening Assays, Antitumor; Female; Gamma Rays; Humans; Pyrans; Pyrimidines; Radiation-Sensitizing Agents; Sulfonamides; Thiazoles | 2011 |
1-oxoeudesm-11(13)-ene-12,8α-lactone-induced apoptosis via ROS generation and mitochondria activation in MCF-7 cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Fractionation; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Female; Hepatocytes; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Membrane Potential, Mitochondrial; Mitochondria; Reactive Oxygen Species; Sesquiterpenes, Eudesmane; Tetrazolium Salts; Thiazoles | 2011 |
Comparison of in vitro cytotoxicity, estrogenicity and anti-estrogenicity of triclosan, perfluorooctane sulfonate and perfluorooctanoic acid.
Topics: Alkanesulfonic Acids; Breast Neoplasms; Caprylates; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Environmental Pollutants; Estrogen Antagonists; Estrogens, Non-Steroidal; Female; Fluorocarbons; Humans; Tetrazolium Salts; Thiazoles; Triclosan | 2013 |
Lack of angiogenesis in experimental brain metastases.
Topics: Angiopoietin-1; Animals; Brain Neoplasms; Breast Neoplasms; Bromodeoxyuridine; Carcinoma; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease Models, Animal; DNA-Binding Proteins; Electron Microscope Tomography; Female; Glial Fibrillary Acidic Protein; Humans; Keratins; Lamins; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Quinolines; Receptor, Platelet-Derived Growth Factor beta; Thiazoles; Vascular Endothelial Growth Factor A | 2011 |
Two new imidazolone-containing alkaloids and further metabolites from the ascomycete fungus Tricladium sp.
Topics: Alkaloids; Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Ascomycota; Breast Neoplasms; Cell Line, Tumor; Drug Evaluation, Preclinical; Female; HIV-1; Humans; Imidazoles; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Thiazoles; Tryptamines | 2011 |
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.
Topics: Breast Neoplasms; Carrier Proteins; Cell Proliferation; ERRalpha Estrogen-Related Receptor; Female; Humans; Nitriles; Receptor, ErbB-2; Receptor, IGF Type 1; Receptors, Estrogen; RNA-Binding Proteins; Signal Transduction; Thiazoles | 2011 |
Dasatinib as a single agent in triple-negative breast cancer: results of an open-label phase 2 study.
Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Dasatinib; Female; Humans; Middle Aged; Protein Kinase Inhibitors; Pyrimidines; Receptor, ErbB-2; Receptors, Estrogen; Receptors, Progesterone; src-Family Kinases; Thiazoles | 2011 |
Synthesis of novel isatin-thiazoline and isatin-benzimidazole conjugates as anti-breast cancer agents.
Topics: Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Chromatography, Thin Layer; Drug Screening Assays, Antitumor; Female; Humans; Indicators and Reagents; Isatin; MCF-7 Cells; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thiazoles | 2011 |
Dasatinib synergizes with both cytotoxic and signal transduction inhibitors in heterogeneous breast cancer cell lines--lessons for design of combination targeted therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Breast Neoplasms; Butadienes; Cell Line, Tumor; Chromones; Dasatinib; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epothilones; Female; Humans; Morpholines; Niacinamide; Nitriles; Paclitaxel; Phenylurea Compounds; Pyridines; Pyrimidines; Signal Transduction; Sirolimus; Sorafenib; Tamoxifen; Thiazoles | 2012 |
Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Breast Neoplasms; Butyrates; Cell Line, Tumor; Cell Survival; Chemotherapy, Adjuvant; Female; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Lactic Acid; Monocarboxylic Acid Transporters; Muscle Proteins; Pyruvates; Tetrazolium Salts; Thiazoles | 2012 |
Preparation of a cationic nanoemulsome for intratumoral drug delivery and its enhancing effect on cellular uptake in vitro.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cations; Caveolae; Cell Line, Tumor; Cells, Cultured; Cetrimonium; Cetrimonium Compounds; CHO Cells; Clathrin; Coumarins; Cricetinae; Drug Carriers; Drug Delivery Systems; Emulsions; Female; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Nanoparticles; Particle Size; Pinocytosis; Polymers; Solvents; Thiazoles | 2011 |
Effects of the combination of RAD001 and docetaxel on breast cancer stem cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Docetaxel; Dose-Response Relationship, Drug; Everolimus; Female; Humans; Immunohistochemistry; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Mice, Nude; Sirolimus; Stem Cells; Taxoids; Tetrazolium Salts; Thiazoles | 2012 |
Dual inhibition of sphingosine kinase isoforms ablates TNF-induced drug resistance.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Isoenzymes; NF-kappa B; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Thiazoles; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2012 |
Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dasatinib; Female; Humans; Indoles; Neoplasm Invasiveness; Paxillin; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Sulfonamides; Thiazoles | 2012 |
Uptake rate of cationic mitochondrial inhibitor MKT-077 determines cellular oxygen consumption change in carcinoma cells.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Kinetics; Mammary Neoplasms, Animal; Mathematical Concepts; Mitochondria; Oxygen Consumption; Pyridines; Rats; Thiazoles | 2012 |
Phosphosignature predicts dasatinib response in non-small cell lung cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Dasatinib; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Humans; Integrin beta4; Lung Neoplasms; Mass Spectrometry; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proteome; Pyrimidines; Thiazoles | 2012 |
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle Proteins; Cell Line; Cell Line, Tumor; Checkpoint Kinase 1; Cyclins; Deoxycytidine; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, SCID; Mitosis; Nuclear Proteins; Polycomb Repressive Complex 2; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Quinolines; S Phase; Thiazoles; Thiophenes; Transcription Factors; Tumor Burden; Tumor Suppressor Protein p53; Urea; Xenograft Model Antitumor Assays | 2012 |
CIL-102 binds to tubulin at colchicine binding site and triggers apoptosis in MCF-7 cells by inducing monopolar and multinucleated cells.
Topics: Apoptosis; Binding Sites; Breast Neoplasms; Calorimetry; Cell Line, Tumor; Cell Proliferation; Humans; Kinetics; Spectrometry, Fluorescence; Tetrazolium Salts; Thermodynamics; Thiazoles; Tubulin | 2012 |
Peptidomimetic Src/pretubulin inhibitor KX-01 alone and in combination with paclitaxel suppresses growth, metastasis in human ER/PR/HER2-negative tumor xenografts.
Topics: Acetamides; Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dasatinib; Drug Synergism; Estrogen Receptor alpha; Female; Focal Adhesion Kinase 1; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Morpholines; Neoplasm Invasiveness; Neoplasm Micrometastasis; Neovascularization, Pathologic; Paclitaxel; Peptidomimetics; Pyridines; Pyrimidines; Receptor, ErbB-2; Receptors, Progesterone; src-Family Kinases; Thiazoles; Tubulin Modulators; Tumor Burden; Xenograft Model Antitumor Assays | 2012 |
RKI-1447 is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer.
Topics: Animals; Antineoplastic Agents; Binding Sites; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Crystallography, X-Ray; Cytoskeleton; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Models, Molecular; Molecular Structure; Neoplasm Invasiveness; NIH 3T3 Cells; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; rho-Associated Kinases; Substrate Specificity; Thiazoles; Tumor Burden; Urea | 2012 |
Lab reports and cat scans: can veterinary oncology guide our way to new treatments for human cancers?
Topics: Animals; Antineoplastic Agents; Benzamides; Breast Neoplasms; Cats; Disease Models, Animal; Dogs; Female; Humans; Imatinib Mesylate; Indoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mast-Cell Sarcoma; Neoplasms; Piperazines; Piperidines; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Thiazoles; Transcriptome | 2012 |
Sphingosine kinase isoforms as a therapeutic target in endocrine therapy resistant luminal and basal-A breast cancer.
Topics: Adamantane; Aminophenols; Animals; Antineoplastic Agents, Hormonal; Base Sequence; Breast Neoplasms; Cell Line, Tumor; DNA Primers; Drug Resistance, Neoplasm; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Female; Humans; Isoenzymes; Mice; Mice, Nude; Mice, SCID; Phosphotransferases (Alcohol Group Acceptor); Pyridines; Real-Time Polymerase Chain Reaction; Receptors, Estrogen; Thiazoles; Xenograft Model Antitumor Assays | 2012 |
Tumor suppression by small molecule inhibitors of translation initiation.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Cell Transformation, Neoplastic; Eukaryotic Initiation Factor-2; Eukaryotic Initiation Factor-4F; Female; Humans; Hydrazones; Indoles; Male; Melanoma; Mice; Mice, Nude; Nitro Compounds; Peptide Chain Initiation, Translational; Phosphorylation; Protein Biosynthesis; RNA, Messenger; Thiazoles; Xenograft Model Antitumor Assays | 2012 |
The V-ATPase-inhibitor archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1.
Topics: Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Polarity; Down-Regulation; ErbB Receptors; Female; Humans; Macrolides; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; rab5 GTP-Binding Proteins; rac1 GTP-Binding Protein; Thiazoles; Vacuolar Proton-Translocating ATPases; Xenograft Model Antitumor Assays | 2012 |
Novel SN38 conjugate-forming nanoparticles as anticancer prodrug: in vitro and in vivo studies.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Cycle; Cell Line, Tumor; Cell Survival; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Mice, Nude; Micelles; Nanoparticles; Prodrugs; Solubility; Tetrazolium Salts; Thiazoles; Xenograft Model Antitumor Assays | 2013 |
Chiral 6,7-bis(hydroxymethyl)-1H,3H-pyrrolo[1,2-c]thiazoles with anti-breast cancer properties.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; MCF-7 Cells; Models, Molecular; Molecular Structure; Pyrroles; Structure-Activity Relationship; Thiazoles | 2013 |
Reversal of multidrug resistance-associated protein-mediated daunorubicin resistance by camptothecin.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Camptothecin; Cell Line; Cell Nucleus; Chemokines, CC; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Microscopy, Confocal; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2002 |
A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus.
Topics: Antineoplastic Agents; Base Sequence; Binding Sites; Breast Neoplasms; Drug Screening Assays, Antitumor; Epothilones; Epoxy Compounds; Female; Genetic Engineering; Glioma; HL-60 Cells; Humans; Inhibitory Concentration 50; Leukemia, Promyelocytic, Acute; Leukemia, T-Cell; Lung Neoplasms; Mass Spectrometry; Molecular Sequence Data; Molecular Structure; Multienzyme Complexes; Myxococcus xanthus; Nuclear Magnetic Resonance, Biomolecular; Thiazoles; Tubulin; Tumor Cells, Cultured | 2002 |
Which dosing scheme is suitable for the taxanes? An in vitro model.
Topics: Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Division; Cell Survival; Docetaxel; Female; Humans; Indicators and Reagents; Paclitaxel; Taxoids; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2002 |
Induction of breast cancer resistance protein by the camptothecin derivative DX-8951f is associated with minor reduction of antitumour activity.
Topics: Acridines; Animals; Antigens, CD; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Camptothecin; Cell Division; DNA Topoisomerases, Type I; Drug Resistance, Neoplasm; Female; Humans; Immunoenzyme Techniques; Isoquinolines; Membrane Glycoproteins; Mice; Mice, Nude; Mutation; Neoplasm Proteins; Neoplasms, Experimental; Ovarian Neoplasms; Tetrahydroisoquinolines; Tetraspanin 29; Tetrazolium Salts; Thiazoles; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 2002 |
Genotoxic profiling of MCF-7 breast cancer cell line elucidates gene expression modifications underlying toxicity of the anticancer drug 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole.
Topics: Antineoplastic Agents; Breast Neoplasms; Female; Gene Expression; Gene Expression Profiling; Humans; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Tumor Cells, Cultured | 2003 |
Peroxisome proliferator-activated receptor gamma agonists induce proteasome-dependent degradation of cyclin D1 and estrogen receptor alpha in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Cell Division; Cyclin D1; Cysteine Endopeptidases; Down-Regulation; Estrogen Receptor alpha; G1 Phase; Humans; Multienzyme Complexes; Prostaglandin D2; Proteasome Endopeptidase Complex; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; RNA, Messenger; S Phase; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Ubiquitin | 2003 |
Effects of introduction of dThdPase cDNA on sensitivity to 5'-deoxy-5-fluorouridine and tumor angiogenesis.
Topics: Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Survival; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Floxuridine; Genetic Vectors; Humans; Immunohistochemistry; Inhibitory Concentration 50; Neoplasm Transplantation; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Thymidine Phosphorylase; Time Factors; Transfection | 2003 |
Oxidative stress and bioindicators of reproductive function in pulp and paper mill effluent exposed white sucker.
Topics: Androgen Antagonists; Androgen Receptor Antagonists; Androgens; Breast Neoplasms; Cell Line; Dexamethasone; Dichlorodiphenyl Dichloroethylene; Dihydrotestosterone; Female; Glucocorticoids; Humans; Insecticides; Linuron; Luciferases; Oxidative Stress; Plasmids; Promoter Regions, Genetic; Receptors, Glucocorticoid; Sunscreening Agents; Testosterone Congeners; Tetrazolium Salts; Thiazoles; Transcriptional Activation; Ultraviolet Rays | 2003 |
Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells.
Topics: Adenocarcinoma; Antigens, Differentiation; Antigens, Neoplasm; Breast Neoplasms; Caveolin 1; Caveolin 2; Caveolins; Cell Differentiation; Cell Line; Chromans; Colonic Neoplasms; Dimerization; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Genes, Dominant; Humans; Kidney; Ligands; Macromolecular Substances; Membrane Microdomains; Neoplasm Proteins; Phenotype; Phenylacetates; Prostaglandin D2; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; RNA, Neoplasm; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone; Tumor Cells, Cultured | 2003 |
Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells.
Topics: Apoptosis; Benzoates; Breast Neoplasms; Cell Division; Female; Gene Expression Regulation, Neoplastic; Humans; Ligands; Lung Neoplasms; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoids; Thiazoles; Thiazolidinediones; Transcription Factors; Tumor Cells, Cultured | 2003 |
A novel polyamine analog inhibits growth and induces apoptosis in human breast cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Caspase 3; Caspases; Cell Death; Cell Division; Cell Line, Tumor; Cell Nucleus; Cell Survival; Chromatin; Cytochromes c; Cytoplasm; Cytosol; DNA Damage; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Microscopy, Fluorescence; Models, Chemical; Neoplasm Transplantation; Nucleosomes; Poly(ADP-ribose) Polymerases; Polyamines; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-jun; Tetrazolium Salts; Thiazoles; Time Factors; Up-Regulation | 2003 |
Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Densitometry; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Genes, Reporter; Genistein; Humans; NF-kappa B; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Transfection; Tumor Cells, Cultured | 2003 |
The pesticide malathion induces alterations in actin cytoskeleton and in cell adhesion of cultured breast carcinoma cells.
Topics: Actins; beta Catenin; Blotting, Western; Breast Neoplasms; Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Nucleus; Cell Survival; Cholinesterase Inhibitors; Coloring Agents; Cytoskeletal Proteins; Cytoskeleton; Electrophoresis; Humans; Insecticides; Malathion; Microscopy, Fluorescence; rac1 GTP-Binding Protein; rho GTP-Binding Proteins; Tetrazolium Salts; Thiazoles; Time Factors; Trans-Activators | 2003 |
Cyclin D1 repression of peroxisome proliferator-activated receptor gamma expression and transactivation.
Topics: 3T3 Cells; Animals; Breast; Breast Neoplasms; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; Cyclin D1; Ecdysterone; Epithelial Cells; Fatty Liver; Female; Gene Expression Regulation; Humans; Mice; Mice, Mutant Strains; Mice, Transgenic; Models, Molecular; Mutation; Protein Conformation; Receptors, Cytoplasmic and Nuclear; Reference Values; Repressor Proteins; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation | 2003 |
Antitumor benzothiazoles. Frontier molecular orbital analysis predicts bioactivation of 2-(4-aminophenyl)benzothiazoles to reactive intermediates by cytochrome P4501A1.
Topics: Antineoplastic Agents; Benzothiazoles; Binding Sites; Biotransformation; Breast Neoplasms; Cations; Cell Death; Cytochrome P-450 CYP1A1; DNA Adducts; Dose-Response Relationship, Drug; Female; Humans; Hydrocarbons, Fluorinated; Models, Molecular; Oxidation-Reduction; Thiazoles; Tumor Cells, Cultured | 2003 |
Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line.
Topics: BRCA1 Protein; Breast Neoplasms; Female; Genetic Predisposition to Disease; Humans; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Enhanced cytotoxicity and nuclear accumulation of doxorubicin-loaded nanospheres in human breast cancer MCF7 cells expressing MRP1.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Cell Nucleus; Coloring Agents; Doxorubicin; Flow Cytometry; Humans; Inhibitory Concentration 50; Microscopy, Confocal; Microscopy, Fluorescence; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Phenotype; RNA, Messenger; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
AZETEPA (NSC-64826) IN STAGE IV BREAST CANCER.
Topics: Alkylating Agents; Amides; Antineoplastic Agents; Azirines; Biomedical Research; Breast Neoplasms; Drug Therapy; Heterocyclic Compounds; Humans; Neoplasms; Phosphinic Acids; Thiazoles; Toxicology | 1964 |
Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B.
Topics: Annexin A5; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Chromatin; Coloring Agents; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Cysteine Endopeptidases; Deoxycytidine; Detergents; Docetaxel; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Epothilones; Flow Cytometry; Gemcitabine; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Microscopy, Fluorescence; Multienzyme Complexes; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; Sepharose; Taxoids; Tetrazolium Salts; Thiazoles; Time Factors; Trastuzumab | 2003 |
Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor.
Topics: Antineoplastic Agents, Hormonal; Apoptosis; Base Sequence; Benzamides; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; DNA Primers; DNA, Neoplasm; Estrogen Receptor Modulators; Humans; Thiazoles; Transcriptional Activation; Zinc Fingers | 2004 |
In vitro and in vivo characterization of doxorubicin and vincristine coencapsulated within liposomes through use of transition metal ion complexation and pH gradient loading.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Calcimycin; Cell Line, Tumor; Coloring Agents; Doxorubicin; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Ionophores; Ions; Lipid Metabolism; Liposomes; Manganese; Manganese Compounds; Mice; Mice, SCID; Neoplasm Transplantation; Protons; Sulfates; Tetrazolium Salts; Thiazoles; Time Factors; Vincristine | 2004 |
Synthesis and evaluation of substituted 4-aryloxy- and 4-arylsulfanyl-phenyl-2-aminothiazoles as inhibitors of human breast cancer cell proliferation.
Topics: Breast Neoplasms; Cell Division; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Estrogens; Female; Humans; Inhibitory Concentration 50; Structure-Activity Relationship; Thiazoles | 2004 |
COX inhibitors modulate bFGF-induced cell survival in MCF-7 breast cancer cells.
Topics: Apoptosis; Aspirin; Breast Neoplasms; CDC2-CDC28 Kinases; Cell Division; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase 2; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytoprotection; Fibroblast Growth Factor 2; Gene Expression Regulation, Neoplastic; Humans; Inhibitor of Apoptosis Proteins; Isoenzymes; MAP Kinase Signaling System; Meloxicam; Membrane Proteins; Microtubule-Associated Proteins; Mitochondria; Mitogen-Activated Protein Kinases; Neoplasm Proteins; Phosphorylation; Prostaglandin-Endoperoxide Synthases; Proto-Oncogene Proteins c-bcl-2; Survivin; Thiazines; Thiazoles | 2004 |
Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Chromones; Copper; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Activation; Enzyme Inhibitors; Epithelial Cells; Humans; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Proto-Oncogene Proteins; Signal Transduction; Thiazoles; Tumor Suppressor Protein p53; Zinc | 2004 |
A cytoskeleton-based functional genetic screen identifies Bcl-xL as an enhancer of metastasis, but not primary tumor growth.
Topics: Animals; bcl-X Protein; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cytoskeleton; Genetic Techniques; Genetic Vectors; Humans; Mammary Neoplasms, Experimental; MAP Kinase Kinase 1; Mice; Mitogen-Activated Protein Kinase Kinases; Neoplasm Metastasis; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Thiazolidines | 2004 |
Treatment of HER-2/neu overexpressing breast cancer xenograft models with trastuzumab (Herceptin) and gefitinib (ZD1839): drug combination effects on tumor growth, HER-2/neu and epidermal growth factor receptor expression, and viable hypoxic cell fraction
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Survival; Coloring Agents; Dose-Response Relationship, Drug; Down-Regulation; ErbB Receptors; Female; Flow Cytometry; Gefitinib; Humans; Hypoxia; Mammary Neoplasms, Animal; Mice; Mice, SCID; Neoplasm Transplantation; Phosphorylation; Quinazolines; Receptor, ErbB-2; Subcellular Fractions; Tetrazolium Salts; Thiazoles; Time Factors; Trastuzumab | 2004 |
Activation of peroxisome proliferator-activated receptor delta stimulates the proliferation of human breast and prostate cancer cell lines.
Topics: Breast Neoplasms; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Female; Gene Expression; Genes, cdc; Genes, Reporter; Humans; Ligands; Luciferases; Male; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Response Elements; RNA, Messenger; Signal Transduction; Thiazoles; Transcription Factors; Transcriptional Activation | 2004 |
Mifepristone induces growth arrest, caspase activation, and apoptosis of estrogen receptor-expressing, antiestrogen-resistant breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Caspases; Cell Line, Tumor; Cell Proliferation; Coloring Agents; DNA Fragmentation; Drug Resistance, Neoplasm; Enzyme Activation; Estradiol; Estrogen Receptor Modulators; Fulvestrant; G1 Phase; Hormone Antagonists; Humans; Immunoblotting; Mifepristone; Phosphorylation; Receptors, Estrogen; Receptors, Progesterone; Resting Phase, Cell Cycle; Tamoxifen; Tetrazolium Salts; Thiazoles; Time Factors | 2004 |
The experimental antitumor agents Phortress and doxorubicin are equiactive against human-derived breast carcinoma xenograft models.
Topics: Animals; Antibiotics, Antineoplastic; Breast Neoplasms; Cytochrome P-450 CYP1A1; DNA Adducts; Doxorubicin; Drug Screening Assays, Antitumor; Female; Humans; Mice; Mice, Nude; Neoplasms, Experimental; Prodrugs; Thiazoles; Transplantation, Heterologous | 2004 |
Effects of polybrominated diphenyl ethers on basal and TCDD-induced ethoxyresorufin activity and cytochrome P450-1A1 expression in MCF-7, HepG2, and H4IIE cells.
Topics: Animals; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cytochrome P-450 CYP1A1; Environmental Pollutants; Female; Humans; L-Lactate Dehydrogenase; Luciferases; Oxazines; Polybrominated Biphenyls; Polychlorinated Dibenzodioxins; Rats; Receptors, Aryl Hydrocarbon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Xanthenes | 2004 |
Beta-parvin inhibits integrin-linked kinase signaling and is downregulated in breast cancer.
Topics: Actinin; Adenoviridae; Amino Acid Sequence; Antibodies; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Collagen; Coloring Agents; DNA, Complementary; Down-Regulation; Drug Combinations; Epidermal Growth Factor; Genes, Reporter; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Laminin; Models, Genetic; Molecular Sequence Data; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proteoglycans; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tetrazolium Salts; Thiazoles; Transfection; Two-Hybrid System Techniques; Up-Regulation | 2004 |
RNA expression of human telomerase subunits TR and TERT is differentially affected by melatonin receptor agonists in the MCF-7 tumor cell line.
Topics: Acetamides; Breast Neoplasms; Catalytic Domain; Female; Humans; Hypnotics and Sedatives; Melatonin; Receptors, Melatonin; RNA; Signal Transduction; Telomerase; Thiazoles; Thiosemicarbazones; Tumor Cells, Cultured | 2004 |
Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2.
Topics: Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Survival; DNA-Binding Proteins; Drug Resistance, Neoplasm; Female; Humans; Proto-Oncogene Proteins c-bcl-2; Receptor, ErbB-2; STAT3 Transcription Factor; Thiazoles; Trans-Activators | 2004 |
Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events.
Topics: Benz(a)Anthracenes; Benzo(a)pyrene; Benzothiazoles; Breast Neoplasms; Bromodeoxyuridine; Carcinogens; Carcinoma; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Replication; Dose-Response Relationship, Drug; Drug Interactions; Epigenesis, Genetic; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Receptors, Estrogen; Thiazoles; Toluene; Tumor Suppressor Protein p53 | 2005 |
Bone marrow stromal cell-derived growth inhibitor inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis.
Topics: Amino Acid Sequence; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Blotting, Northern; Blotting, Western; Bone Marrow Cells; Breast Neoplasms; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Coloring Agents; Cyclin A; Cyclin-Dependent Kinase Inhibitor p27; DNA, Complementary; Down-Regulation; Gene Library; Genetic Vectors; HeLa Cells; Humans; Molecular Sequence Data; Phylogeny; Proteins; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; S Phase; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Tetrazolium Salts; Thiazoles; Tissue Distribution; Transfection; Tumor Suppressor Proteins; Up-Regulation; Wound Healing | 2005 |
Role of breast cancer resistance protein (Bcrp1/Abcg2) in the extrusion of glucuronide and sulfate conjugates from enterocytes to intestinal lumen.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzothiazoles; Breast Neoplasms; Drug Resistance, Multiple; Enterocytes; Gene Deletion; Glucuronides; Hyperbilirubinemia; Intestinal Absorption; Intestinal Mucosa; Jejunum; Kinetics; Mammary Neoplasms, Animal; Mice; Mice, Knockout; Pyridines; Rats; Sulfates; Thiazoles | 2005 |
E2F4 deficiency promotes drug-induced apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; E2F4 Transcription Factor; Fibroblasts; Flavonoids; Humans; Lung Neoplasms; Mice; Mice, Knockout; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; RNA, Small Interfering; Roscovitine; Thiazoles; Transcription Factors; Tumor Cells, Cultured | 2004 |
In vitro, in vivo, and in silico analyses of the antitumor activity of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazoles.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Comet Assay; Computational Biology; Cytochrome P-450 CYP1A1; DNA Adducts; DNA Damage; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Humans; In Vitro Techniques; Membranes, Artificial; Mice; Mice, Nude; Thiazoles; Time Factors; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2004 |
Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study.
Topics: Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Cyclohexanones; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Fibroblast Growth Factor 2; Fibroblasts; Humans; Hypoxia; In Vitro Techniques; Neovascularization, Pathologic; Thiazoles | 2005 |
Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines.
Topics: Alkenes; Apoptosis; Blotting, Western; Breast Neoplasms; Caspases; Cell Line, Tumor; Cell Nucleus; Cell Survival; Coloring Agents; Cytochromes c; DNA Damage; Dose-Response Relationship, Drug; Genes, Reporter; Humans; Luciferases; Phenols; Plasmids; Receptors, Estrogen; Tetrazolium Salts; Thiazoles | 2005 |
Effects of X-ray irradiation on the overexpression of HER-2/Erb-B2 on breast cancer cell lines.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Breast Neoplasms; Cell Line, Tumor; Coloring Agents; Dose-Response Relationship, Radiation; Humans; Immunohistochemistry; In Vitro Techniques; Neoplasm Metastasis; Receptor, ErbB-2; Tetrazolium Salts; Thiazoles; Time Factors; Trastuzumab; Trypan Blue; X-Rays | 2004 |
HERG K+ channel expression-related chemosensitivity in cancer cells and its modulation by erythromycin.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Biomarkers; Breast Neoplasms; Camptothecin; Carcinoma; Colonic Neoplasms; Coloring Agents; Drug Interactions; Drug Resistance, Neoplasm; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression Profiling; Humans; Lung Neoplasms; Paclitaxel; Potassium Channels, Voltage-Gated; Tetrazolium Salts; Thiazoles; Transfection; Vincristine | 2005 |
Elucidation of thioredoxin as a molecular target for antitumor quinols.
Topics: Amino Acid Sequence; Antineoplastic Agents; Benzothiazoles; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Colonic Neoplasms; Cyclohexanones; Drug Screening Assays, Antitumor; Humans; Hydroquinones; Insulin; Mass Spectrometry; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Sulfones; Thiazoles; Thioredoxins | 2005 |
Characterization of the activities of actin-affecting drugs on tumor cell migration.
Topics: Actins; Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Movement; Cytochalasin D; Cytoskeleton; Depsipeptides; Humans; Inhibitory Concentration 50; Lung Neoplasms; Neoplasm Invasiveness; Statistics, Nonparametric; Thiazoles; Thiazolidines | 2006 |
Characterizations of irofulven cytotoxicity in combination with cisplatin and oxaliplatin in human colon, breast, and ovarian cancer cells.
Topics: Algorithms; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cisplatin; Colonic Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Genes, p53; HT29 Cells; Humans; Organoplatinum Compounds; Ovarian Neoplasms; Oxaliplatin; Sesquiterpenes; Tetrazolium Salts; Thiazoles | 2006 |
Evaluation of reduced toxicity of zearalenone by extrusion processing as measured by the MTT cell proliferation assay.
Topics: Breast Neoplasms; Cell Division; Cell Line, Tumor; Chromatography, High Pressure Liquid; Coloring Agents; Edible Grain; Enzyme-Linked Immunosorbent Assay; Food Handling; Humans; Tetrazolium Salts; Thiazoles; Zearalenone | 2005 |
Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines.
Topics: Acetyltransferases; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Hydrogen Peroxide; Oxidoreductases Acting on CH-NH Group Donors; Peroxisomes; Polyamine Oxidase; Polyamines; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Interference; RNA, Messenger; RNA, Small Interfering; Spermine; Tetrazolium Salts; Thiazoles; Time Factors; Transfection | 2005 |
Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha.
Topics: Apoptosis; Aryl Hydrocarbon Hydroxylases; Benzo(a)pyrene; Benzothiazoles; Breast Neoplasms; Carcinogens; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1B1; Humans; Leukemia; Macrophages; Microsomes, Liver; Protein Isoforms; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2006 |
Targeted therapy against Bcl-2-related proteins in breast cancer cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Genes, bcl-2; Humans; Mice; Mice, Nude; Oligonucleotides, Antisense; Proto-Oncogene Proteins c-bcl-2; Tetrazolium Salts; Thiazoles; Transplantation, Heterologous; Tumor Cells, Cultured | 2005 |
Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast.
Topics: Breast Neoplasms; Butyrates; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Female; Humans; Phenylurea Compounds; Phthalic Acids; Plasticizers; PPAR alpha; PPAR gamma; PPAR-beta; Statistics, Nonparametric; Thiazoles; Thiazolidinediones; Transfection | 2006 |
Anti-tumor drug candidate 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole induces single-strand breaks and DNA-protein cross-links in sensitive MCF-7 breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Humans; Thiazoles | 2006 |
Adiponectin induces growth arrest and apoptosis of MDA-MB-231 breast cancer cell.
Topics: Adiponectin; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Female; Humans; Plasmids; Recombinant Proteins; Tetrazolium Salts; Thiazoles | 2005 |
Effects of PPAR and RXR ligands in semaphorin 6B gene expression of human MCF-7 breast cancer cells.
Topics: Alitretinoin; Blotting, Western; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromans; Dimerization; Fenofibrate; Gene Expression; HT29 Cells; Humans; K562 Cells; PPAR alpha; PPAR gamma; Retinoid X Receptors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Semaphorins; Thiazoles; Thiazolidinediones; Tretinoin; Troglitazone | 2006 |
Growth-inhibitory action of melatonin and thiazolidinedione derivative CGP 52608 on murine 16/C breast cancer cells.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Melatonin; Methotrexate; Mice; Nuclear Receptor Subfamily 1, Group F, Member 2; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Statistics, Nonparametric; Thiazoles; Thiosemicarbazones | 2006 |
Synthesis, characterization, and biological evaluation of M(I)(CO)3(NNO) complexes (M = Re, 99mTc) conjugated to 2-(4-aminophenyl)benzothiazole as potential breast cancer radiopharmaceuticals.
Topics: Animals; Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Cell Line; Cell Line, Tumor; Female; Fibroblasts; Humans; Mice; Organometallic Compounds; Radiopharmaceuticals; Rhenium; Structure-Activity Relationship; Technetium; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2006 |
Synthesis of carbon-11 labeled sulfonanilide analogues as new potential PET agents for imaging of aromatase in breast cancer.
Topics: Adult; Anilides; Aromatase Inhibitors; Breast Neoplasms; Carbon Radioisotopes; Cell Line, Tumor; Cyclooxygenase 2 Inhibitors; Drug Design; Female; Humans; Indicators and Reagents; Isotope Labeling; Nitrobenzenes; Positron-Emission Tomography; Radiopharmaceuticals; Sulfonamides; Tetrazolium Salts; Thiazoles | 2007 |
Investigating the mechanism of enhanced cytotoxicity of HPMA copolymer-Dox-AGM in breast cancer cells.
Topics: Aminoglutethimide; Antineoplastic Agents; Apoptosis; beta-Cyclodextrins; Breast Neoplasms; Cell Survival; Chlorpromazine; Cytochalasin B; Doxorubicin; Endocytosis; Female; Flow Cytometry; Humans; Immunohistochemistry; Ki-67 Antigen; Kinetics; Liver; Lysosomes; Methacrylates; Microscopy, Confocal; Proto-Oncogene Proteins c-bcl-2; Tetrazolium Salts; Thiazoles | 2007 |
Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/"triple-negative" breast cancer cell lines growing in vitro.
Topics: Administration, Oral; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dasatinib; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Keratins; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-abl; Pyrimidines; Sensitivity and Specificity; src-Family Kinases; Thiazoles; Vimentin | 2007 |
Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Dasatinib; Drug Resistance, Neoplasm; Gene Expression Profiling; Humans; Models, Genetic; Patient Selection; Prognosis; Pyrimidines; Thiazoles | 2007 |
Antitumor properties of diastereomeric and geometric analogs of vitamin D3.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Calcitriol; Calcium; Carcinoma, Lewis Lung; CD11b Antigen; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cholecalciferol; Coloring Agents; Female; Fibroblasts; HL-60 Cells; Humans; Lipopolysaccharide Receptors; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pancreatic Neoplasms; Prostatic Neoplasms; Rhodamines; Stereoisomerism; Tetrazolium Salts; Thiazoles | 2007 |
Dasatinib may also inhibit c-Kit in triple negative breast cancer cell lines.
Topics: Breast Neoplasms; Cell Line, Tumor; Dasatinib; Drug Screening Assays, Antitumor; ErbB Receptors; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Thiazoles | 2008 |
Diminished feedback regulation of proteasome expression and resistance to proteasome inhibitors in breast cancer cells.
Topics: Apoptosis; Boronic Acids; Bortezomib; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Feedback, Physiological; Humans; Leupeptins; Protease Inhibitors; Proteasome Endopeptidase Complex; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; Temperature; Tetrazolium Salts; Thiazoles | 2008 |
Paradoxical proliferative potential of iron (II) sulphate on cancer cells after the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay.
Topics: Breast Neoplasms; Carcinoma; Cell Proliferation; Colony-Forming Units Assay; Humans; Iron Compounds; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasms; Sulfates; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2007 |
Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-alpha inverse agonist XCT790.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Line, Tumor; Drug Synergism; ERRalpha Estrogen-Related Receptor; Estradiol; Estrogen Receptor alpha; Female; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; Nitriles; Prognosis; Proteasome Endopeptidase Complex; Receptors, Estrogen; Thiazoles | 2007 |
Potential targeted therapy options in the management of basal cell subtype of breast carcinoma.
Topics: Albumin-Bound Paclitaxel; Albumins; Antineoplastic Agents; Breast Neoplasms; Caveolin 1; CD146 Antigen; Clinical Trials, Phase III as Topic; Dasatinib; Drug Delivery Systems; Female; Humans; Neoplasms, Basal Cell; Paclitaxel; Proto-Oncogene Proteins c-met; Pyrimidines; Thiazoles | 2007 |
PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line.
Topics: Acetaldehyde; Alcohol Dehydrogenase; Aldehyde Oxidoreductases; Breast Neoplasms; Cell Line, Tumor; Cyanamide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Female; Fomepizole; Gene Expression Regulation, Neoplastic; Humans; PPAR alpha; PPAR-beta; Pyrazoles; RNA, Messenger; Thiazoles; Transcription, Genetic; Transcriptional Activation; Transfection | 2008 |
Aberrant expression of Fra-1 in estrogen receptor-negative breast cancers and suppression of their propagation in vivo by ascochlorin, an antibiotic that inhibits cellular activator protein-1 activity.
Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Longevity; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Phenols; Proto-Oncogene Proteins c-fos; Receptors, Estrogen; Survival Analysis; Tetrazolium Salts; Thiazoles; Transcription Factor AP-1; Xenograft Model Antitumor Assays | 2007 |
BRCA1 modulates sensitivity to 5F-203 by regulating xenobiotic stress-inducible protein levels and EROD activity.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Prodrugs; RNA, Small Interfering; Thiazoles; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases | 2008 |
3-methyl-2-(4-substituted phenyl)-4,5-dihydronaphtho[1,2-c]-pyrazoles: synthesis and in-vitro biological evaluation as antitumour agents.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Drug Screening Assays, Antitumor; Female; Humans; Inhibitory Concentration 50; Pyrazoles; Structure-Activity Relationship; Thiazoles | 2008 |
Inhibition of tumor cell growth by a human B-cell line.
Topics: Adenocarcinoma; Antigens, CD20; B-Lymphocytes; Breast Neoplasms; Cell Survival; Coloring Agents; Herpesvirus 4, Human; Humans; Immunity, Cellular; Killer Cells, Lymphokine-Activated; Leukemia, Hairy Cell; Lymphocytes, Tumor-Infiltrating; Polymerase Chain Reaction; Receptors, Antigen, B-Cell; Receptors, Interleukin-2; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1994 |
Synthesis and biological activity of thiazolylindolequinones, analogues of the natural product BE 10988.
Topics: Aerobiosis; Animals; Breast Neoplasms; Cell Hypoxia; CHO Cells; Cricetinae; Cricetulus; Drug Evaluation, Preclinical; HeLa Cells; Humans; Indoles; Quinones; Structure-Activity Relationship; Thiazoles; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1995 |
A possible mechanism for the cytotoxicity of a polyacetylenic alcohol, panaxytriol: inhibition of mitochondrial respiration.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Alkynes; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Death; Enediynes; Fatty Alcohols; Humans; Microscopy, Electron; Mitochondria; Oxygen; Rhodamines; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1995 |
The identification of drug resistance in ovarian cancer and breast cancer: application of the MTT assay.
Topics: Adenocarcinoma; Breast Neoplasms; Colorimetry; Coloring Agents; Drug Resistance; Drug Screening Assays, Antitumor; Feasibility Studies; Female; Humans; Neoplasm Staging; Ovarian Neoplasms; Pilot Projects; Predictive Value of Tests; Prognosis; Tetrazolium Salts; Thiazoles | 1994 |
Structural studies on bioactive compounds. 23. Synthesis of polyhydroxylated 2-phenylbenzothiazoles and a comparison of their cytotoxicities and pharmacological properties with genistein and quercetin.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Colonic Neoplasms; ErbB Receptors; Fibroblasts; Genistein; Humans; Hydroxylation; Isoflavones; Mice; Molecular Structure; Protein-Tyrosine Kinases; Quercetin; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 1994 |
Genistein inhibits tumour cell growth in vitro but enhances mitochondrial reduction of tetrazolium salts: a further pitfall in the use of the MTT assay for evaluating cell growth and survival.
Topics: Animals; Breast Neoplasms; Cell Count; Formazans; Genistein; Growth Inhibitors; Humans; Isoflavones; Mitochondria; Mitosis; Protein-Tyrosine Kinases; Rhodamines; Stimulation, Chemical; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1993 |
Anti-proliferative effects of the arotinoid Ro 40-8757 on human cancer cell lines in vitro.
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Division; Cell Survival; Colorectal Neoplasms; Drug Screening Assays, Antitumor; Humans; Kinetics; Lung Neoplasms; Morpholines; Neoplasms; Receptors, Estrogen; Retinoids; Tetrazolium Salts; Thiazoles; Tretinoin; Tumor Cells, Cultured | 1993 |
Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Benzimidazoles; Benzothiazoles; Benzoxazoles; Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Female; Humans; Metallothionein 3; Mice; Mice, Nude; Structure-Activity Relationship; Thiazoles; Transplantation, Heterologous | 1996 |
Antitumor activity of paclitaxel against human breast carcinoma xenografts serially transplanted into nude mice.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Coloring Agents; Cyclophosphamide; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Mice; Mice, Nude; Mitomycin; Neoplasm Transplantation; Paclitaxel; Tetrazolium Salts; Thiazoles; Transplantation, Heterologous; Tumor Cells, Cultured | 1997 |
Cell line specific radiosensitizing effect of zalcitabine (2',3'-dideoxycytidine).
Topics: Breast Neoplasms; Cell Cycle; Colonic Neoplasms; Flow Cytometry; Humans; Radiation-Sensitizing Agents; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Zalcitabine | 1997 |
Antiproliferative effect of curcumin (diferuloylmethane) against human breast tumor cell lines.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Division; Cell Line; Curcumin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Ornithine Decarboxylase; Tetrazolium Salts; Thiazoles | 1997 |
Synthesis and cytotoxic activity of indolyl thiazoles.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Drug Screening Assays, Antitumor; Humans; Indoles; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1997 |
Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells.
Topics: Animals; Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cattle; Cell Division; Colchicine; Cyclopropanes; DNA, Neoplasm; Drug Interactions; G2 Phase; Humans; Mitosis; Models, Chemical; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Thiazoles; Tubulin; Tumor Cells, Cultured | 1998 |
2-(4-Aminophenyl)benzothiazoles: novel agents with selective profiles of in vitro anti-tumour activity.
Topics: Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Carcinoma; Cell Cycle; Colonic Neoplasms; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Estrogens; Female; Growth Inhibitors; Humans; Kidney Neoplasms; Male; Melanoma; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Skin Neoplasms; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 1998 |
Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice.
Topics: Adenocarcinoma; Animals; Apoptosis; Breast; Breast Neoplasms; Cell Differentiation; Chromans; Genes, bcl-2; Humans; Hypoglycemic Agents; Ligands; Mice; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone; Tumor Cells, Cultured | 1998 |
Sensitization effect of L-2-oxothiazolidine-4-carboxylate on tumor cells to melphalan and the role of 5-oxo-L-prolinase in glutathione modulation in tumor cells.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Synergism; Glutathione; Humans; Melphalan; Pyroglutamate Hydrolase; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines; Tumor Cells, Cultured | 1998 |
Evaluation of in vitro chemosensitivity of antitumor drugs using the MTT assay in fresh human breast cancer.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Survival; Coloring Agents; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Humans; Regression Analysis; Tetrazolium Salts; Thiazoles | 1998 |
Desoxyepothilone B is curative against human tumor xenografts that are refractory to paclitaxel.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Survival; Drug Resistance, Neoplasm; Epothilones; Female; Humans; Lactones; Leukemia P388; Leukemia-Lymphoma, Adult T-Cell; Mice; Mice, Nude; Ovarian Neoplasms; Paclitaxel; Structure-Activity Relationship; Thiazoles; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
The effect of the flavonoids, quercetin, myricetin and epicatechin on the growth and enzyme activities of MCF7 human breast cancer cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Catechin; Cell Division; Flavonoids; Glutathione; Humans; L-Lactate Dehydrogenase; Neoplasm Proteins; Oxidation-Reduction; Quercetin; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1998 |
Peptide YY inhibits growth of human breast cancer in vitro and in vivo.
Topics: Animals; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Division; Cell Survival; Coloring Agents; Cyclic AMP; Female; Humans; Intracellular Membranes; Mice; Mice, Nude; Peptide YY; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1999 |
Predictive chemotherapy of advanced breast cancer directed by MTT assay in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colorimetry; Coloring Agents; Drug Resistance, Neoplasm; Female; Humans; Middle Aged; Predictive Value of Tests; Prospective Studies; Survival Analysis; Tetrazolium Salts; Thiazoles; Treatment Outcome; Tumor Cells, Cultured | 1999 |
Relationship between size and thiazole orange fluorescence of platelets in patients undergoing high-dose chemotherapy.
Topics: Antineoplastic Agents; Benzothiazoles; Blood Platelets; Breast Neoplasms; Erythrocyte Indices; Female; Flow Cytometry; Fluorescent Dyes; Humans; Quinolines; Thiazoles | 1999 |
Telomerase enzyme activity and RNA expression in adriamycin-resistant human breast carcinoma MCF-7 cells.
Topics: Antineoplastic Agents, Phytogenic; Blotting, Western; Breast Neoplasms; Carcinoma; Cell Count; Cell Division; Cell Survival; Docetaxel; Doxorubicin; Drug Resistance, Neoplasm; Electrophoresis, Agar Gel; Female; Fluorouracil; Gene Expression; Humans; Paclitaxel; Polymerase Chain Reaction; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Taxoids; Telomerase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1999 |
Shared antigenic epitopes and pathobiological functions of anti-p185(her2/neu) monoclonal antibodies.
Topics: 3T3 Cells; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Binding Sites, Antibody; Breast Neoplasms; Cell Transformation, Neoplastic; Cross Reactions; Epitopes; Female; Flow Cytometry; Humans; Immunoenzyme Techniques; Immunoglobulin Variable Region; Male; Mice; Models, Molecular; Prostatic Neoplasms; Rats; Receptor, ErbB-2; Tetrazolium Salts; Thiazoles; Trastuzumab | 1999 |
Peroxisome proliferator-activated receptor gamma activation in human breast cancer.
Topics: Breast Neoplasms; Cell Division; DNA-Binding Proteins; Female; Genes, Reporter; Humans; Hypoglycemic Agents; Prostaglandins; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Recombinant Proteins; Retinoid X Receptors; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured | 1999 |
Differential IGF-independent effects of insulin-like growth factor binding proteins (1-6) on apoptosis of breast epithelial cells.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Size; Cell Survival; Ceramides; Dose-Response Relationship, Drug; Epithelial Cells; Female; Flow Cytometry; Humans; Insulin-Like Growth Factor Binding Proteins; Ligands; Oligopeptides; Somatomedins; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1999 |
[Predictive chemotherapy of breast cancer directed by MTT assay in vitro].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Coloring Agents; Cyclophosphamide; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Fluorouracil; Humans; Methotrexate; Prospective Studies; Tetrazolium Salts; Thiazoles | 1997 |
Antitumour benzothiazoles. Part 10: the synthesis and antitumour activity of benzothiazole substituted quinol derivatives.
Topics: Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Hydroquinones; Oxidation-Reduction; Thiazoles; Tumor Cells, Cultured | 2000 |
Peroxisome proliferator-activated receptor gamma ligands inhibit estrogen biosynthesis in human breast adipose tissue: possible implications for breast cancer therapy.
Topics: Adipose Tissue; Animals; Aromatase; Aromatase Inhibitors; Binding, Competitive; Breast; Breast Neoplasms; Cell Line; Cells, Cultured; Chromans; Dose-Response Relationship, Drug; Estrogens; Female; Gene Expression Regulation, Enzymologic; Humans; Ligands; Promoter Regions, Genetic; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Recombinant Fusion Proteins; Rosiglitazone; Stromal Cells; Thiazoles; Thiazolidinediones; Transcription Factors; Transcription, Genetic; Troglitazone | 2000 |
Modulation of daunorubicin toxicity by liposomal encapsulation and use of specific inhibitors in vitro.
Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Daunorubicin; Drug Carriers; Drug Compounding; Drug Resistance, Neoplasm; Humans; Liposomes; Rutin; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2000 |
Peptide YY and vitamin E inhibit hormone-sensitive and -insensitive breast cancer cells.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Division; Cell Survival; Coloring Agents; Female; Humans; Peptide YY; Receptors, Estrogen; Tetrazolium Salts; Thiazoles; Tocopherols; Tumor Cells, Cultured; Vitamin E | 2000 |
Synthesis and cytotoxic activity of thiazolyl indolequinones.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line; CHO Cells; Cricetinae; Drug Screening Assays, Antitumor; Humans; Indoles; Lung Neoplasms; Magnetic Resonance Spectroscopy; Mass Spectrometry; Quinones; Spectrophotometry, Infrared; Thiazoles; Tumor Cells, Cultured | 1999 |
Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells.
Topics: Aniline Compounds; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Benzothiazoles; Breast Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; Isoenzymes; Mixed Function Oxygenases; Protein Binding; Substrate Specificity; Thiazoles; Tumor Cells, Cultured | 2000 |
Effect of low dose irradiation on estrogen receptor level in MCF-7 breast cancer cells.
Topics: Binding Sites; Blotting, Western; Breast Neoplasms; Cell Division; Cell Survival; Coloring Agents; Dose-Response Relationship, Radiation; Electrophoresis, Polyacrylamide Gel; Estradiol; Humans; Immunohistochemistry; Pregnenediones; Protein Binding; Receptors, Estrogen; Receptors, Progesterone; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured | 2001 |
A mathematical model of in vitro cancer cell growth and treatment with the antimitotic agent curacin A.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma; Cyclopropanes; Female; Flow Cytometry; Humans; Inhibitory Concentration 50; Kinetics; Mitosis; Models, Biological; Ovarian Neoplasms; Thiazoles; Tumor Cells, Cultured | 2001 |
Antitumour benzothiazoles. Part 15: The synthesis and physico-chemical properties of 2-(4-aminophenyl)benzothiazole sulfamate salt derivatives.
Topics: Amines; Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Drug Stability; Enzyme Activators; Female; Guanylate Cyclase; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Platelet Aggregation Inhibitors; Prodrugs; Solubility; Sulfonic Acids; Thiazoles; Tumor Cells, Cultured | 2001 |
BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Survival; Colonic Neoplasms; Disease Models, Animal; Drug Resistance, Neoplasm; Epothilones; Epoxy Compounds; Female; Humans; Infusions, Parenteral; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Ovarian Neoplasms; Paclitaxel; Pancreatic Neoplasms; Sarcoma; Thiazoles; Tubulin; Tumor Cells, Cultured; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2001 |
Neoadjuvant chemotherapy in inoperable, locally advanced, and inflammatory breast carcinoma: a pilot study of MTT assay in vitro and outcome analysis of 10 patients.
Topics: Adenocarcinoma; Adult; Breast Neoplasms; Coloring Agents; Drug Screening Assays, Antitumor; Humans; Middle Aged; Neoplasm Staging; Pilot Projects; Tetrazolium Salts; Thiazoles | 2001 |
Magnitude of peroxisome proliferator-activated receptor-gamma activation is associated with important and seemingly opposite biological responses in breast cancer cells.
Topics: Apoptosis; Breast Neoplasms; Cell Cycle; Cell Differentiation; Cell Division; Chromans; Female; Humans; Prostaglandin D2; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Troglitazone; Tumor Cells, Cultured | 2001 |
Troglitazone inhibits growth of MCF-7 breast carcinoma cells by targeting G1 cell cycle regulators.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Blotting, Western; Breast Neoplasms; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cell Separation; Cell Survival; Chromans; Cyclin D1; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Ethanol; Flow Cytometry; G1 Phase; Humans; Ligands; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-jun; Receptors, Cytoplasmic and Nuclear; Retinoblastoma Protein; Thiazoles; Thiazolidinediones; Time Factors; Transcription Factors; Transfection; Troglitazone; Tumor Cells, Cultured | 2001 |
Human MCF10A mammary epithelial cells undergo apoptosis following actin depolymerization that is independent of attachment and rescued by Bcl-2.
Topics: Actins; Apoptosis; bcl-2-Associated X Protein; Breast; Breast Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Adhesion; Cell Line, Transformed; Cell Survival; Epithelial Cells; Female; Humans; Mitochondria; Neoplasm Metastasis; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Transport; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Thiazolidines; Transfection; Tumor Cells, Cultured | 2001 |
Therapeutic effects of viral vector-mediated antiangiogenic gene transfer in malignant ascites.
Topics: Adenoviridae; Angiostatins; Animals; Apoptosis; Ascites; Blotting, Northern; Blotting, Western; Breast Neoplasms; Cell Division; Cell Movement; Cells, Cultured; Collagen; Coloring Agents; Down-Regulation; Endostatins; Endothelial Growth Factors; Endothelium; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Female; Gene Transfer Techniques; Genetic Vectors; Humans; Immunohistochemistry; Lymphokines; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neovascularization, Pathologic; Peptide Fragments; Plasmids; Plasminogen; Platelet Factor 4; Recombinant Fusion Proteins; Signal Transduction; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Umbilical Veins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
Hepatocyte growth factor/scatter factor blocks the mitochondrial pathway of apoptosis signaling in breast cancer cells.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Apoptosis; Apoptosis Inducing Factor; Breast Neoplasms; Caspase 3; Caspases; Coloring Agents; Cysteine Proteinase Inhibitors; Cytochrome c Group; Doxorubicin; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; Flavoproteins; Hepatocyte Growth Factor; Humans; Membrane Glycoproteins; Membrane Potentials; Membrane Proteins; Mitochondria; Recombinant Proteins; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured; Up-Regulation | 2001 |
[Compared study on Fura-2/AM assay and MTT assay for screening multidrug resistant modulators].
Topics: Bepridil; Breast Neoplasms; Calcium Channel Blockers; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Fura-2; Humans; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Verapamil | 1997 |
Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole.
Topics: Active Transport, Cell Nucleus; Aniline Compounds; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Benzothiazoles; Biological Transport; Breast Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme System; Drug Screening Assays, Antitumor; Enzyme Induction; Female; Humans; Promoter Regions, Genetic; Receptors, Aryl Hydrocarbon; Thiazoles; Transcription, Genetic; Tumor Cells, Cultured | 2002 |
Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells.
Topics: Apoptosis; bcl-2-Associated X Protein; Benzothiazoles; Blotting, Western; Breast Neoplasms; Butyrates; Caspase Inhibitors; Cell Cycle; Cell Division; Fas Ligand Protein; fas Receptor; Humans; Membrane Glycoproteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Thiazoles; Toluene; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2002 |
Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Epothilones; Epoxy Compounds; G2 Phase; Humans; Mitochondria; Mitosis; Protein Conformation; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Thiazoles; Tumor Cells, Cultured | 2002 |
Regulation of aromatase by nuclear receptors.
Topics: Aromatase; Benzoates; Breast Neoplasms; Cholecalciferol; Chromans; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Granulosa Cells; Humans; Ligands; Nicotinic Acids; Receptors, Calcitriol; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Retinoids; RNA, Messenger; RNA, Neoplasm; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone; Tumor Cells, Cultured | 2001 |
Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells.
Topics: Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Breast Neoplasms; Calcium Channel Blockers; Cell Survival; Doxycycline; Drug Interactions; Drug Resistance, Multiple; Female; Flow Cytometry; Humans; Immunoblotting; In Situ Hybridization; Lasers; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Verapamil | 2002 |
Inhibition of all-TRANS-retinoic acid metabolism by R116010 induces antitumour activity.
Topics: Animals; Antineoplastic Agents; Benzothiazoles; Breast Neoplasms; Cell Division; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Mixed Function Oxygenases; Retinoic Acid 4-Hydroxylase; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Tretinoin; Tumor Cells, Cultured | 2002 |
Involvement of the mt1 melatonin receptor in human breast cancer.
Topics: Breast Neoplasms; Carbazoles; Cell Division; Dose-Response Relationship, Drug; Humans; Immunoblotting; Luciferases; Melatonin; Nuclear Receptor Subfamily 1, Group F, Member 1; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thiosemicarbazones; Trans-Activators; Tumor Cells, Cultured | 2002 |
Identification of leptin receptors in human breast cancer: functional activity in the T47-D breast cancer cell line.
Topics: Blotting, Western; Breast Neoplasms; Carcinoma, Ductal, Breast; Carrier Proteins; Cell Division; DNA Primers; Female; Humans; In Situ Hybridization; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Middle Aged; Mitogen-Activated Protein Kinase Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Cell Surface; Receptors, Leptin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tetrazolium Salts; Thiazoles; Thymidine; Tumor Cells, Cultured | 2002 |
Interference of plant extracts, phytoestrogens and antioxidants with the MTT tetrazolium assay.
Topics: Acetylcysteine; Antioxidants; Ascorbic Acid; Breast Neoplasms; Cell Division; Cell Survival; Drug Interactions; Estrogens, Non-Steroidal; Flavonoids; Humans; Isoflavones; Kaempferols; Phytoestrogens; Plant Extracts; Plant Preparations; Plants; Quercetin; Resveratrol; Stilbenes; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vitamin E | 2002 |
MTT assays allow quick and reliable measurement of the response of human tumour cells to photodynamic therapy.
Topics: Adenocarcinoma; Breast Neoplasms; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Hematoporphyrin Derivative; Hematoporphyrins; Humans; Photochemotherapy; Radiation-Sensitizing Agents; Sensitivity and Specificity; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1992 |
[Strategy for therapy of malignant ascites using MTT assay].
Topics: Antineoplastic Agents; Ascitic Fluid; Breast Neoplasms; Cisplatin; Clinical Protocols; Doxorubicin; Drug Screening Assays, Antitumor; Female; Fluorouracil; Humans; Mitomycin; Stomach Neoplasms; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1992 |
[Evaluation of predictability of in vitro SDI assay in comparison with in vivo nude mouse assay].
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Drug Screening Assays, Antitumor; Fibroblasts; Gastrointestinal Neoplasms; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Predictive Value of Tests; Reproducibility of Results; Succinate Dehydrogenase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1989 |
Carcinostatic activity of a thiazolidinonylidene-hydrazonothiazolidinone derivative against DMBA-induced mammary carcinomata in female Sprague-Dawley rats.
Topics: Animals; Antineoplastic Agents; Benz(a)Anthracenes; Breast Neoplasms; Carcinoma; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hydrazones; Neoplasms, Experimental; Rats; Thiazoles | 1973 |