thiazoles has been researched along with B-Cell Chronic Lymphocytic Leukemia in 38 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (10.53) | 18.2507 |
| 2000's | 8 (21.05) | 29.6817 |
| 2010's | 25 (65.79) | 24.3611 |
| 2020's | 1 (2.63) | 2.80 |
| Authors | Studies |
|---|---|
| Allan, JN; Arruga, F; Bracciamà, V; Coscia, M; D'Arena, G; Deaglio, S; Forconi, F; Furman, RR; Gaidano, G; Gizzi, K; Packham, G; Vaisitti, T; Vitale, N; Yeomans, A | 1 |
| Berchem, G; Chouha, N; Désaubry, L; François, JH; Moussay, E; Paggetti, J; Pierson, S; Wierz, M | 1 |
| Chaudhari, RR; Chen, R; Chen, Y; Hull, KG; Plunkett, W; Qin, Q; Robles, O; Romo, D; Skillern, W; Wierda, WG; Zhang, S; Zhu, M | 1 |
| Adams, VC; Ahearne, MJ; Beck, D; Wagner, SD; Willimott, S | 1 |
| Fan, L; Han, TT; Li, JY; Xu, W | 1 |
| Beckers, MM; Daenen, S; Doorduijn, JK; Doreen Te Raa, G; Eldering, E; Kater, AP; Lankheet, NA; Liu, RD; Luijks, DM; Slinger, E; Spiering, M; Tonino, SH; van Oers, MH | 1 |
| Kameoka, Y; Kume, M; Nagao, T; Noguchi, S; Ohyagi, H; Sawada, K; Shinohara, Y; Takahashi, N | 1 |
| Cheng, S; Coleman, M; Guo, A; Lu, P; Ma, J; Wang, YL | 1 |
| Hagist, S; Hallek, M; Krause, G; Pallasch, CP; Patz, M; Veldurthy, A; Wendtner, CM | 1 |
| Birgens, H; Brown, Pde N; Dalseg, AM; Dufva, IH; Hasselbalch, HC; Jensen, MK; Vangsted, A | 1 |
| Altavilla, G; Arrigo, C; Pitini, V | 1 |
| Arkin, MR; Conroy, A; Fox, JA; Hawtin, RE; Hoch, U; Stockett, DE; Walker, D | 1 |
| Chen, R; Chubb, S; Fox, JA; Gandhi, V; Hawtin, RE; Keating, MJ; Plunkett, W; Wierda, WG | 1 |
| Ambrosetti, A; Nichele, I; Pizzolo, G; Tecchio, C; Todeschini, G | 1 |
| Aloyz, R; Amrein, L; Gibson, SB; Johnston, JB; Panasci, L; Soulières, D | 1 |
| Coleman, M; Furman, RR; Knowles, DM; Lee, FY; Leonard, JP; Lu, P; Martin, P; Song, Z; Tyrell, L; Wang, YL | 1 |
| Barr, PM; Caimi, PF; Distelhorst, CW; Harr, MW; McColl, KS; Patel, SN; Zhong, F | 1 |
| Badros, AZ; Chen, R; Chen, T; Coutre, S; Fox, JA; Harvey, RD; Hoch, U; Kegley, P; Mahadocon, K; Plunkett, W; Popplewell, L; Siegel, D; Sinha, R; Tong, WG; Wierda, WG | 1 |
| Aloyz, R; Amrein, L; Johnston, JB; Soulières, D | 1 |
| Pitini, VV | 1 |
| Del Fabro, V; Di Raimondo, F; Fidilio, A; Massimino, M; Messina, A; Spina, P; Stagno, F; Vigneri, P | 1 |
| Aldred, VL; Bendit, I; Cavalcante, M; de Paula, HM; Dorlhiac-Llacer, PE; Nardinelli, L; Seguro, F; Serpa, M; Steinbaum, D; Xavier, F | 1 |
| Aul, C; Erlemann, R; Giagounidis, A; Haase, S; Heinsch, M; Radkowski, R; Russwurm, G | 1 |
| Bantscheff, M; Drewes, G; Eberhard, D; Frenzel, L; Ghidelli, S; Kruse, U; Maier, SK; Pallasch, CP; Wendtner, CM; Werner, T | 1 |
| Hallek, M; Krause, G | 1 |
| Chen, R; Chen, Y; Guo, L; Jiang, Y; Plunkett, W; Wierda, WG | 1 |
| Bosco, R; Cuneo, A; Marmiroli, S; Melloni, E; Rigolin, GM; Secchiero, P; Voltan, R; Zauli, G | 1 |
| Cosimo, E; Leach, MT; McCaig, AM; Michie, AM | 1 |
| Amrein, PC; Armand, P; Attar, EC; Ballen, KK; Brown, JR; Fisher, DC; Hasserjian, RP; Hochberg, EP; Jacobsen, ED; Lacasce, AS; Leahy, KM; Neuberg, D; Takvorian, T; Werner, L | 1 |
| Beaumont, T; Breij, EC; Eldering, E; Elias, JA; Geest, CR; Kater, AP; Luijks, DM; Tromp, JM; van Laar, J; van Oers, MH | 1 |
| Claasen, J; Frenzel, LP; Gehrke, I; Hallek, M; Krause, G; Kuckertz, M; Patz, M; Veldurthy, A; Wendtner, CM | 1 |
| Bianchino, G; D'Arena, G; D'Auria, F; Deaglio, S; Del Vecchio, L; Gemei, M; Grieco, V; Guariglia, R; Luciano, L; Mansueto, G; Martorelli, MC; Musto, P; Pietrantuono, G; Statuto, T; Villani, O | 1 |
| Apollonio, B; Barbaglio, F; Bertilaccio, MT; Caligaris-Cappio, F; Ghia, P; Ponzoni, M; Scarfò, L; Scielzo, C; Stamatopoulos, K; ten Hacken, E | 1 |
| Joshi, SS; Pavletic, ZS; Wang, P | 1 |
| Alaoui-Jamali, M; Aubin, R; Batist, G; Bramson, J; Christodoulopoulos, G; McQuillan, A; Panasci, LC | 1 |
| Brugiatelli, M; Callea, I; Callea, V; Console, G; Morabito, F; Stelitano, C | 1 |
| Lambert, E; Rees, JK; Twentyman, PR | 1 |
| Rozmysłowicz, T | 1 |
3 review(s) available for thiazoles and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Role of chemokines and their receptors in chronic lymphocytic leukemia: function in microenvironment and targeted therapy.
Topics: Aminopyridines; Antineoplastic Agents; Benzylamines; Chemokine CXCL12; Clinical Trials as Topic; Cyclams; Dasatinib; Heterocyclic Compounds; Humans; Lenalidomide; Leukemia, Lymphocytic, Chronic, B-Cell; Molecular Targeted Therapy; Morpholines; Niacinamide; Oxazines; Phenylurea Compounds; Protein Kinase Inhibitors; Purines; Pyridines; Pyrimidines; Quinazolinones; Receptors, CXCR4; Sorafenib; Thalidomide; Thiazoles; Tumor Microenvironment | 2014 |
Dasatinib-responsive chronic lymphocytic leukemia in a patient treated for coexisting chronic myeloid leukemia.
Topics: Aged, 80 and over; Antineoplastic Agents; Chromosome Deletion; Chromosome Disorders; Chromosomes, Human, Pair 13; Dasatinib; Female; Genes, abl; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Neoplasms, Multiple Primary; Protein Kinase Inhibitors; Pyrimidines; Thiazoles | 2013 |
[Novel medical treatment modalities in hematology].
Topics: Aminoglycosides; Anemia, Hemolytic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Benzamides; Benzoates; Boronic Acids; Bortezomib; Carbazoles; Carrier Proteins; Cyclophosphamide; Dasatinib; Furans; Gemtuzumab; Hematologic Diseases; Humans; Hydrazines; Imatinib Mesylate; Immunologic Factors; Indoles; Lenalidomide; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Piperazines; Purpura, Thrombocytopenic; Pyrazines; Pyrazoles; Pyrimidines; Receptors, Fc; Recombinant Fusion Proteins; Rituximab; Thalidomide; Thiazoles; Thrombopoietin; Vidarabine | 2008 |
5 trial(s) available for thiazoles and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Dasatinib in combination with fludarabine in patients with refractory chronic lymphocytic leukemia: a multicenter phase 2 study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Dasatinib; Drug Administration Schedule; Fatigue; Female; Gene Expression Regulation, Leukemic; Humans; Kaplan-Meier Estimate; Leukemia, Lymphocytic, Chronic, B-Cell; Lymph Nodes; Male; Middle Aged; Nausea; NF-kappa B; Pneumonia; Pyrimidines; Thiazoles; Thrombocytopenia; Treatment Outcome; Vidarabine | 2014 |
SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samples.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cyclin-Dependent Kinases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Multiple Myeloma; Oxazoles; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles | 2009 |
Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma.
Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Cohort Studies; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Maximum Tolerated Dose; Middle Aged; Multiple Myeloma; Oxazoles; Survival Rate; Thiazoles; Tissue Distribution; Treatment Outcome | 2010 |
Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; B-Lymphocytes; Benzoquinones; CD40 Ligand; Cell Line, Tumor; Cell Survival; Dasatinib; Dose-Response Relationship, Drug; Drug Synergism; Female; HSP90 Heat-Shock Proteins; Humans; Interleukin-4; Intracellular Signaling Peptides and Proteins; Lactams, Macrocyclic; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Receptors, Antigen, B-Cell; Signal Transduction; Stromal Cells; Syk Kinase; Thiazoles; Time Factors | 2011 |
Phase II study of dasatinib in relapsed or refractory chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Dasatinib; Drug Resistance, Neoplasm; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Pyrimidines; Radiography, Abdominal; Recurrence; Thiazoles; Tomography, X-Ray Computed | 2011 |
30 other study(ies) available for thiazoles and B-Cell Chronic Lymphocytic Leukemia
| Article | Year |
|---|---|
Bidirectional linkage between the B-cell receptor and NOTCH1 in chronic lymphocytic leukemia and in Richter's syndrome: therapeutic implications.
Topics: Adenine; Adult; Aged; Aged, 80 and over; Amyloid Precursor Protein Secretases; Animals; Calcium; Diamines; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Mice; Mice, Inbred NOD; Mice, SCID; Middle Aged; Piperidines; Pyrazoles; Pyrimidines; Receptor, Notch1; Receptors, Antigen, B-Cell; Signal Transduction; Syndrome; Thiazoles | 2020 |
The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells
Topics: Animals; Apoptosis; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Prohibitins; Proto-Oncogene Proteins c-bcl-2; Repressor Proteins; Thiazoles; Transcriptional Activation; Tumor Cells, Cultured | 2018 |
Creating novel translation inhibitors to target pro-survival proteins in chronic lymphocytic leukemia.
Topics: Aged; Aged, 80 and over; Apoptosis; Biomarkers, Tumor; Bridged Bicyclo Compounds, Heterocyclic; Drug Synergism; Drug Therapy, Combination; Epoxy Compounds; Eukaryotic Initiation Factor-4A; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Male; Middle Aged; Models, Molecular; Myeloid Cell Leukemia Sequence 1 Protein; Prognosis; Protein Biosynthesis; Protein Conformation; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Sulfonamides; Thiazoles; Tumor Cells, Cultured | 2019 |
Cap-translation inhibitor, 4EGI-1, restores sensitivity to ABT-737 apoptosis through cap-dependent and -independent mechanisms in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Apoptosis Regulatory Proteins; Biphenyl Compounds; Cell Line, Tumor; Drug Resistance, Neoplasm; Elafin; Female; Gene Expression Regulation, Neoplastic; Humans; Hydrazones; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Nitro Compounds; Nitrophenols; Piperazines; Protein Biosynthesis; Sulfonamides; Thiazoles | 2013 |
Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors.
Topics: Adenine; Agammaglobulinaemia Tyrosine Kinase; Antineoplastic Agents; B-Lymphocytes; Cell Line, Tumor; Cyclohexylamines; Dasatinib; Drug Resistance, Neoplasm; Female; Gene Expression; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Mutation; Piperidines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrroles; RNA, Small Interfering; Signal Transduction; Structure-Activity Relationship; Thiazoles | 2015 |
The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes.
Topics: bcl-X Protein; Caspases; Dasatinib; Dose-Response Relationship, Drug; Drug Synergism; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Kinetics; Leukemia, Lymphocytic, Chronic, B-Cell; Myeloid Cell Leukemia Sequence 1 Protein; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Thiazoles; Tumor Cells, Cultured; Vidarabine | 2008 |
Dasatinib induces a response in chronic lymphocytic leukemia.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Blood Cell Count; Dasatinib; Female; Fusion Proteins, bcr-abl; Hemorrhage; Humans; Imatinib Mesylate; Jejunal Diseases; Leukemia, Lymphocytic, Chronic, B-Cell; Liver Neoplasms; Magnetic Resonance Imaging; Middle Aged; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Remission Induction; Rituximab; src-Family Kinases; Thiazoles; Tomography, X-Ray Computed; Vidarabine | 2009 |
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Caspases; Cyclin-Dependent Kinases; Female; Flavonoids; Humans; Immunoblotting; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Male; Membrane Potential, Mitochondrial; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Polymerase II; RNA, Neoplasm; Roscovitine; Thiazoles; Transcription, Genetic; X-Linked Inhibitor of Apoptosis Protein | 2009 |
Dasatinib-induced response in a rare case of chronic lymphocytic leukaemia associated with chronic myeloid leukaemia.
Topics: Antineoplastic Agents; Dasatinib; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; Protein Kinase Inhibitors; Pyrimidines; Remission Induction; Thiazoles | 2009 |
Primary del 17 chronic lymphocytic leukaemia lymphocytes are hypersensitive to dasatinib in vitro.
Topics: Chromosome Deletion; Chromosomes, Human, Pair 17; Dasatinib; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Tumor Cells, Cultured | 2009 |
Activities of SYK and PLCgamma2 predict apoptotic response of CLL cells to SRC tyrosine kinase inhibitor dasatinib.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Biomarkers, Pharmacological; Cell Death; Dasatinib; Enzyme Activation; Female; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Phospholipase C gamma; Prognosis; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; src-Family Kinases; Syk Kinase; Thiazoles; Tumor Cells, Cultured | 2010 |
Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia.
Topics: Animals; Apoptosis; B-Lymphocytes; Calcium Signaling; Cell Line, Tumor; Cells, Cultured; Dasatinib; Dexamethasone; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Profiling; Glucocorticoids; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Lymphocytes; Mice; Mice, Inbred Strains; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Receptors, Antigen, T-Cell; RNA, Small Interfering; Signal Transduction; T-Lymphocytes; Thiazoles; Tumor Cells, Cultured | 2010 |
p53 and autophagy contribute to dasatinib resistance in primary CLL lymphocytes.
Topics: Antineoplastic Agents; Autophagy; Dasatinib; Drug Resistance, Neoplasm; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pyrimidines; Thiazoles; Tumor Suppressor Protein p53 | 2011 |
The role of p53 and autophagy in Dasatinib resistance of CLL lymphocytes.
Topics: Antineoplastic Agents; Autophagy; Dasatinib; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pyrimidines; Thiazoles; Tumor Suppressor Protein p53 | 2011 |
Unsuccessful dasatinib therapy in a refractory patient with chronic lymphocytic leukemia.
Topics: Aged; Dasatinib; Drug Resistance, Neoplasm; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Treatment Failure | 2010 |
Response to dasatinib in a patient with concomitant chronic myeloid leukemia and chronic lymphocytic leukemia.
Topics: Aged; Biopsy; Dasatinib; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Treatment Outcome | 2010 |
Dasatinib induces complete remission in a patient with primary cerebral involvement of B-cell chronic lymphocytic leukemia failing chemotherapy.
Topics: Aged; Brain; Dasatinib; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Magnetic Resonance Imaging; Male; Protein Kinase Inhibitors; Pyrimidines; Remission Induction; Thiazoles | 2010 |
Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.
Topics: Apoptosis; Flavonoids; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Oxazoles; Piperidines; Positive Transcriptional Elongation Factor B; Protein Kinase Inhibitors; Proteomics; Thiazoles | 2011 |
On the assessment of dasatinib-induced autophagy in CLL.
Topics: Antineoplastic Agents; Autophagy; Dasatinib; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pyrimidines; Thiazoles | 2011 |
Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Proliferation; Drug Synergism; Drug Therapy, Combination; Harringtonines; Homoharringtonine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Middle Aged; Mitochondrial Membranes; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stromal Cells; Thiazoles; Tumor Cells, Cultured | 2011 |
Dasatinib plus Nutlin-3 shows synergistic antileukemic activity in both p53 wild-type and p53 mutated B chronic lymphocytic leukemias by inhibiting the Akt pathway.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Dasatinib; Down-Regulation; Drug Synergism; Humans; Imidazoles; Leukemia, Lymphocytic, Chronic, B-Cell; Mutation; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Proto-Oncogene Proteins c-akt; Pyrimidines; Thiazoles; Transcription, Genetic; Tumor Suppressor Protein p53 | 2011 |
Tipping the Noxa/Mcl-1 balance overcomes ABT-737 resistance in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Biphenyl Compounds; CD40 Antigens; CD40 Ligand; Coculture Techniques; Dasatinib; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymph Nodes; Mice; Middle Aged; Minor Histocompatibility Antigens; Myeloid Cell Leukemia Sequence 1 Protein; NF-kappa B; NIH 3T3 Cells; Nitrophenols; p38 Mitogen-Activated Protein Kinases; Piperazines; Proto-Oncogene Proteins c-bcl-2; Pyrimidines; Signal Transduction; Sulfonamides; Thiazoles; Tumor Cells, Cultured; Vidarabine | 2012 |
Comparison of the effects of two kinase inhibitors, sorafenib and dasatinib, on chronic lymphocytic leukemia cells.
Topics: Benzenesulfonates; Cell Survival; Dasatinib; Dose-Response Relationship, Drug; Humans; Lethal Dose 50; Leukemia, Lymphocytic, Chronic, B-Cell; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Sorafenib; Thiazoles; Treatment Outcome; Tumor Cells, Cultured | 2012 |
Chronic lymphocytic leukemia after chronic myeloid leukemia in the same patient: two different genomic events and a common treatment?
Topics: Aged, 80 and over; Antineoplastic Agents; Benzamides; Dasatinib; Female; Flow Cytometry; Genome, Human; Humans; Imatinib Mesylate; Immunophenotyping; In Situ Hybridization, Fluorescence; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoid Progenitor Cells; Myeloid Progenitor Cells; Neoplasms, Second Primary; Neoplastic Stem Cells; Piperazines; Pyrimidines; Thiazoles | 2012 |
Targeting the LYN/HS1 signaling axis in chronic lymphocytic leukemia.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Blood Proteins; Cell Survival; Cells, Cultured; Dasatinib; Enzyme Activation; Female; Gene Expression Regulation, Leukemic; Leukemia, Lymphocytic, Chronic, B-Cell; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Targeted Therapy; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; Signal Transduction; src-Family Kinases; Thiazoles; Xenograft Model Antitumor Assays | 2013 |
Increased apoptosis in B-chronic lymphocytic leukemia cells as a result of cyclin D3 down regulation.
Topics: Annexin A5; Apoptosis; Apoptosis Regulatory Proteins; Caenorhabditis elegans Proteins; Cell Cycle; Cell Division; Cell Line, Tumor; Coloring Agents; Cyclin D3; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases; Cyclins; Down-Regulation; Fluorescein-5-isothiocyanate; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Oligonucleotides, Antisense; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Vidarabine | 2002 |
Nitrogen mustard drug resistant B-cell chronic lymphocytic leukemia as an in vivo model for crosslinking agent resistance.
Topics: B-Lymphocytes; Chlorambucil; Cisplatin; Cross-Linking Reagents; DNA Adducts; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Resistance; Humans; Inactivation, Metabolic; Leukemia, Lymphocytic, Chronic, B-Cell; Melphalan; Methyl Methanesulfonate; Mitomycin; Nitrogen Mustard Compounds; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1995 |
In vitro drug-induced cytotoxicity predicts clinical response to high-dose chlorambucil in B-cell chronic lymphocytic leukemia.
Topics: Aged; Antineoplastic Agents, Alkylating; Cell Survival; Chlorambucil; Coloring Agents; Drug Screening Assays, Antitumor; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Multivariate Analysis; Neoplastic Stem Cells; Remission Induction; Tetrazolium Salts; Thiazoles; Treatment Outcome | 1999 |
Resistance circumvention strategies tested in clinical leukaemia specimens using the MTT colorimetric assay.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vincristine | 1992 |
[Effect of thioproline in vitro on selected functions of peripheral blood lymphocytes from healthy persons and patients with lympho- proliferative syndromes].
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; B-Lymphocytes; Blood Donors; Cyclic AMP; Cyclic GMP; Cytotoxicity, Immunologic; DNA; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Models, Biological; T-Lymphocytes; Thiazoles; Thiazolidines | 1991 |