Page last updated: 2024-08-21

thiazoles and Amyotrophic Lateral Sclerosis

thiazoles has been researched along with Amyotrophic Lateral Sclerosis in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	40 (60.61)	18.2507
2000's	5 (7.58)	29.6817
2010's	18 (27.27)	24.3611
2020's	3 (4.55)	2.80

Authors

Authors	Studies
Boopathy, S; Brown, RH; Danielson, EW; Fallini, C; Giampetruzzi, A; Gumina, V; Jeon, M; Landers, JE; Ratti, A	1
van Den Berg, LH; van Eijk, RPA	1
Chen, JJ	1
Alamón, C; Barbeito, L; Hermine, O; Ibarburu, S; King, PH; Kovacs, M; Kwon, Y; Maciel, C; Si, Y; Tarragó, L; Trias, E; Varela, V	1
Scott, A	1
Barbeito, L; Barreto-Núñez, R; Beckman, JS; Dubreuil, P; Hermine, O; Ibarburu, S; Moura, IC; Trias, E; Varela, V	1
Kiernan, MC	1
Barbeito, L; Beckman, JS; Hermine, O; Ibarburu, S; King, PH; Kovacs, M; Kwon, Y; Moura, IC; Si, Y; Trias, E; Varela, V	1
Dolgin, E	1
Che, X; Ding, X; Feng, S; Ma, M; Teng, J; Wang, X; Wu, E; Zhang, W; Zhang, Y; Zhou, S	1
Camacho, J; Gamez, J; Salvado, M; Simon-Talero, M; Vargas, V; Vidal, M	1
Babdor, J; Barbeito, L; Barreto-Núñez, R; Beckman, JS; Cassina, P; Díaz-Amarilla, P; Dubreuil, P; Gros, L; Guillo, M; Hermine, O; Ibarburu, S; Maciel, TT; Martínez-Palma, L; Moura, IC; Trias, E	1
Drannik, A; Jiang, F; Ma, X; Peterson, R; Turnbull, J	1
Chia, R; Collinge, J; Fisher, EM; Jackson, GS; Jones, S; Tattum, MH	1
Fan, D; Tang, L; Wang, J; Zhang, N; Zhang, Y	1
Ahn, SW; Choi, WJ; Hong, YH; Kim, JE; Kim, SH; Kim, SM; Lee, KW; Park, KS; Sung, JJ	1
Hadano, S; Hirayama, N; Ikeda, JE; Kanno, T; Tanaka, K; Yanagisawa, Y; Yasutake, K; Yoshii, F	1
Adachi, H; Huang, Z; Ishigaki, S; Katsumata, R; Katsuno, M; Kawai, K; Sobue, G; Sone, J; Tanaka, F; Urano, F	1
Botelho, HM; Cardoso, I; Fritz, G; Gomes, CM; Leal, SS; Morozova-Roche, LA; Yanamandra, K	1
Gardberg, M; Jansson, L; Kaasinen, V; Martikainen, MH; Rinne, JO; Röyttä, M	1
Chen, YR; Chiang, CH; Kuo, PH; Liang, JR; Shen, JC; Wang, S; Wang, YT; Yuan, HS	1
Cashman, NR; Chakrabartty, A; Crow, JP; Cunningham, P; Dahan, S; Furtos-Matei, A; Kondejewski, LH; Qi, XF; Rakhit, R	1
Beretta, S; Carrì, MT; Casciati, A; Ceresa, C; Ferrarese, C; Ferri, A; Mattavelli, L; Sala, G	1
Bennett, JP; Gerber, RE; Pattee, GL; Post, GR	1
Bendotti, C; Cantoni, L; Lupi, M; Mangolini, A; Rizzardini, M; Ubezio, P	1
Hwang, S; Kim, HY; Kim, SH; Kim, Y; Koh, SH; Lee, CH	1
Nightingale, SL	1
Rowland, LP	2
Burgerman, RS	1
McRae, KD	1
Murphy, JR	1
Rogawski, MA	1
Couratier, P; Esclaire, F; Hugon, J; Louvel, E; Sindou, P	1
Fuller, GN; McKee, P; Stevens, DL	1
Bensimon, G; Lacomblez, L; Meininger, V	1
Bensimon, G; Guillet, P; Lacomblez, L; Leigh, PN; Meininger, V	1
Emami, J; Goonetilleke, A; Guiloff, RJ	1
Martí-Fàbregas, J	1
Andrus, PK; Cutting, FB; Gurney, ME; Hall, ED; Zhai, P	1
Festoff, BW	1
Wokke, J	1
Bouchard, JP; Duquette, P; Eisen, A; Gelinas, D; Harati, Y; Miller, RG; Munsat, TL; Powe, L; Rothstein, J; Salzman, P; Sufit, RL	1
Newman, D; Sufit, R	1
Hugon, J	1
Hobbs, GR; Riggs, JE	1
Bensimon, G; Delumeau, JC; Durrleman, S; Guillet, P; Lacomblez, L; Leigh, PN; Meininger, V; Powe, L	1
Barnes, S	1
Andrus, PK; Cutting, FB; Doble, A; Gurney, ME; Hall, ED; Taylor, CP; Zhai, P	1
Wokke, JH	1
Moriwaka, F	1
Andersen, PM; Forsgren, L; Sojka, P	1
Klappenbach, G; Ludolph, AC; Riepe, MW	1
Shindo, M; Yanagisawa, N	1
Scarlato, G	1
Aubin, F; Dib, M; Jourdain, G; Meininger, V; Zeisser, P	1
Ince, PG; Shaw, PJ	1
Dengler, R; Tröger, M	1
Landis, BE; Wagner, ML	1
Mitsumoto, H	1
Clark, W; Kendall, MJ	1
Brown, RH; Cudkowicz, ME; Ellis, T; Gwilt, PR; Hayden, DL; Sexton, PM; Whalen, J	1

Reviews

11 review(s) available for thiazoles and Amyotrophic Lateral Sclerosis

Article	Year
Amyotrophic lateral sclerosis. Current opinion in neurology, 1994, Volume: 7, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Humans; Immunization, Passive; Motor Neuron Disease; Neurologic Examination; Riluzole; Thiazoles	1994
Pathogenic mechanisms in familial amyotrophic lateral sclerosis due to mutation of Cu, Zn superoxide dismutase. Pathologie-biologie, 1996, Volume: 44, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Animals; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, Pair 21; Excitatory Amino Acid Antagonists; Humans; Mice; Mice, Transgenic; Mutation; Riluzole; Superoxide Dismutase; Thiazoles; Vitamin E	1996
Amyotrophic lateral sclerosis: current and future treatment strategies. Drugs, 1996, Volume: 51, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Apoptosis; Ciliary Neurotrophic Factor; Clinical Trials as Topic; Humans; Insulin-Like Growth Factor I; Nerve Tissue Proteins; Riluzole; Thiazoles	1996
Riluzole. Lancet (London, England), 1996, Sep-21, Volume: 348, Issue:9030 Topics: Amyotrophic Lateral Sclerosis; Animals; Drug Interactions; Female; Humans; Male; Middle Aged; Motor Neuron Disease; Neuroprotective Agents; Riluzole; Thiazoles	1996
Riluzole and ALS therapy. Wiener medizinische Wochenschrift (1946), 1996, Volume: 146, Issue:9-10 Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Motor Neurons; Neurologic Examination; Riluzole; Survival Analysis; Thiazoles	1996
[Amyotrophic lateral sclerosis]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1997, Volume: 72, Issue:1 Topics: Adult; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Animals; Autoimmunity; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Nerve Growth Factors; Nerve Tissue Proteins; Point Mutation; Randomized Controlled Trials as Topic; Riluzole; Superoxide Dismutase; Thiazoles; Threonine	1997
Glutamate, excitotoxicity and amyotrophic lateral sclerosis. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neuroprotective Agents; Receptors, Glutamate; Riluzole; Thiazoles	1997
Impact of riluzole on the relationship between patient and physician. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Attitude; Disease Progression; Emotions; Humans; Neuroprotective Agents; Physician-Patient Relations; Physicians; Riluzole; Thiazoles	1997
Riluzole: a new agent for amyotrophic lateral sclerosis. The Annals of pharmacotherapy, 1997, Volume: 31, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Drug Interactions; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Riluzole; Thiazoles	1997
Therapeutic advances: riluzole for the treatment of motor neurone disease. Journal of clinical pharmacy and therapeutics, 1996, Volume: 21, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Asthenia; Excitatory Amino Acid Antagonists; Health Care Costs; Humans; Quality of Life; Riluzole; Survivors; Thiazoles; Treatment Outcome	1996
Riluzole for amyotrophic lateral sclerosis. Drug and therapeutics bulletin, 1997, Volume: 35, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Riluzole; Thiazoles	1997

Trials

10 trial(s) available for thiazoles and Amyotrophic Lateral Sclerosis

Article	Year
Reduction of oxidative stress in amyotrophic lateral sclerosis following pramipexole treatment. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2003, Volume: 4, Issue:2 Topics: Aged; Amyotrophic Lateral Sclerosis; Antioxidants; Benzothiazoles; Humans; Hydroxybenzoates; Middle Aged; Oxidative Stress; Patient Dropouts; Pramipexole; Thiazoles	2003
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. The New England journal of medicine, 1994, Mar-03, Volume: 330, Issue:9 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prognosis; Proportional Hazards Models; Prospective Studies; Riluzole; Survival Analysis; Thiazoles; Treatment Outcome	1994
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet (London, England), 1996, May-25, Volume: 347, Issue:9013 Topics: Amyotrophic Lateral Sclerosis; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuroprotective Agents; Prognosis; Proportional Hazards Models; Riluzole; Survival Analysis; Thiazoles; Time Factors; Tracheostomy; Treatment Outcome	1996
Clinical trials of riluzole in patients with ALS. ALS/Riluzole Study Group-II. Neurology, 1996, Volume: 47, Issue:4 Suppl 2 Topics: Adult; Amyotrophic Lateral Sclerosis; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Liver; Male; Middle Aged; Neuroprotective Agents; Riluzole; Thiazoles	1996
Riluzole and ALS therapy. Wiener medizinische Wochenschrift (1946), 1996, Volume: 146, Issue:9-10 Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Motor Neurons; Neurologic Examination; Riluzole; Survival Analysis; Thiazoles	1996
A confirmatory dose-ranging study of riluzole in ALS. ALS/Riluzole Study Group-II. Neurology, 1996, Volume: 47, Issue:6 Suppl 4 Topics: Amyotrophic Lateral Sclerosis; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Humans; Male; Middle Aged; Riluzole; Survival Analysis; Thiazoles	1996
Effects of riluzole on symptom progression in amyotrophic lateral sclerosis. Lancet (London, England), 1997, Jan-18, Volume: 349, Issue:9046 Topics: Amyotrophic Lateral Sclerosis; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Riluzole; Thiazoles	1997
Increase of flexor reflex latency in patients with amyotrophic lateral sclerosis treated with riluzole. Journal of neurology, neurosurgery, and psychiatry, 1997, Volume: 62, Issue:4 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Female; Humans; Male; Middle Aged; Reaction Time; Reflex, Stretch; Riluzole; Thiazoles	1997
The Riluzole Early Access Programme: descriptive analysis of 844 patients in France. ALS/Riluzole Study Group III. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Aged; Amyotrophic Lateral Sclerosis; Female; France; Humans; Male; Middle Aged; Neuroprotective Agents; Riluzole; Risk; Survival Analysis; Thiazoles; Time Factors; Tracheostomy; Treatment Failure; Treatment Outcome	1997
The pharmacokinetics and pharmaco-dynamics of Procysteine in amyotrophic lateral sclerosis. Neurology, 1999, Apr-22, Volume: 52, Issue:7 Topics: Administration, Oral; Adult; Amyotrophic Lateral Sclerosis; Glutathione; Humans; Infusions, Intravenous; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1999

Other Studies

46 other study(ies) available for thiazoles and Amyotrophic Lateral Sclerosis

Article	Year
Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis. Nature communications, 2019, 08-23, Volume: 10, Issue:1 Topics: Acrylamides; Actins; Active Transport, Cell Nucleus; Amyotrophic Lateral Sclerosis; Biopsy; Bridged Bicyclo Compounds, Heterocyclic; C9orf72 Protein; Cell Line; Cerebral Cortex; Embryo, Mammalian; Fibroblasts; Humans; Microscopy, Electron, Transmission; Motor Neurons; Mutation; Nuclear Pore; Primary Cell Culture; Profilins; Protein Multimerization; Skin; Thiazoles; Thiazolidines	2019
In pursuit of the normal progressor: the holy grail for ALS clinical trial design? Amyotrophic lateral sclerosis & frontotemporal degeneration, 2020, Volume: 21, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Benzamides; Clinical Trials as Topic; Humans; Piperidines; Pyridines; Riluzole; Thiazoles	2020
Overview of current and emerging therapies for amytrophic lateral sclerosis. The American journal of managed care, 2020, Volume: 26, Issue:9 Suppl Topics: Amyotrophic Lateral Sclerosis; Antibodies, Monoclonal, Humanized; Benzamides; Edaravone; Humans; Mesenchymal Stem Cells; Oligonucleotides; Piperidines; Pyridines; Riluzole; Thiazoles	2020
The pathogenic role of c-Kit+ mast cells in the spinal motor neuron-vascular niche in ALS. Acta neuropathologica communications, 2021, 08-13, Volume: 9, Issue:1 Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Benzamides; Case-Control Studies; Chymases; Cyclooxygenase 2; Female; Humans; Male; Mast Cells; Mice; Microvessels; Middle Aged; Motor Neurons; Neuroinflammatory Diseases; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Spinal Cord; Stem Cell Factor; Thiazoles; Tryptases	2021
Drug therapy: On the treatment trail for ALS. Nature, 2017, 10-18, Volume: 550, Issue:7676 Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Benzamides; C9orf72 Protein; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Edaravone; Genetic Therapy; Humans; Imidazoles; Mesenchymal Stem Cells; Motor Neurons; Neuroglia; Off-Label Use; Oligoribonucleotides, Antisense; Piperidines; Precision Medicine; Pyrazines; Pyridines; Riluzole; RNAi Therapeutics; Stem Cell Transplantation; Superoxide Dismutase; Thiazoles; United States; United States Food and Drug Administration	2017
Evidence for mast cells contributing to neuromuscular pathology in an inherited model of ALS. JCI insight, 2017, 10-19, Volume: 2, Issue:20 Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Benzamides; Disease Models, Animal; Male; Mast Cells; Muscle, Skeletal; Neuromuscular Diseases; Neuromuscular Junction; Piperidines; Pyridines; Rats; Thiazoles	2017
Motor neuron disease in 2017: Progress towards therapy in motor neuron disease. Nature reviews. Neurology, 2018, Volume: 14, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Benzamides; Edaravone; Humans; Muscular Atrophy, Spinal; Neuroprotective Agents; Oligonucleotides; Oligoribonucleotides, Antisense; Piperidines; Pyridines; Thiazoles; Thionucleotides	2018
Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS. JCI insight, 2018, 10-04, Volume: 3, Issue:19 Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Benzamides; Cell Degranulation; Disease Models, Animal; Humans; Male; Mast Cells; Motor Neurons; Muscle, Skeletal; Neuromuscular Junction; Neutrophil Infiltration; Neutrophils; Piperidines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Transgenic; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Treatment Outcome	2018
The brain's traffic problems. Science (New York, N.Y.), 2019, Jan-18, Volume: 363, Issue:6424 Topics: Acrylamides; Active Transport, Cell Nucleus; Amyotrophic Lateral Sclerosis; Animals; Brain; C9orf72 Protein; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Eye; GTPase-Activating Proteins; Mutation; Neurodegenerative Diseases; Nuclear Envelope; Nuclear Pore; Thiazoles	2019
Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy. International journal of biological sciences, 2015, Volume: 11, Issue:7 Topics: Amyotrophic Lateral Sclerosis; Animals; Autophagy; Cell Line; DNA-Binding Proteins; Endoplasmic Reticulum Stress; Flow Cytometry; Immunoblotting; Mice; Neurons; Peptide Fragments; Tetrazolium Salts; Thiazoles; Valproic Acid	2015
Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient. World journal of gastroenterology, 2015, Sep-28, Volume: 21, Issue:36 Topics: Adult; Amyotrophic Lateral Sclerosis; Azathioprine; Benzamides; Biopsy; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Piperidines; Prednisone; Protein Kinase Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Severity of Illness Index; Thiazoles; Time Factors; Treatment Outcome	2015
Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis. Journal of neuroinflammation, 2016, 07-11, Volume: 13, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Animals; Benzamides; Cell Death; Disease Models, Animal; Disease Progression; Encephalitis; Humans; Male; Motor Neurons; Mutation; Neuroglia; Paralysis; Piperidines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Transgenic; Spinal Cord; Superoxide Dismutase; Thiazoles	2016
Crosstalk between Notch and Sonic hedgehog signaling in a mouse model of amyotrophic lateral sclerosis. Neuroreport, 2017, Feb-08, Volume: 28, Issue:3 Topics: Amyotrophic Lateral Sclerosis; Animals; CD11b Antigen; Diamines; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Hedgehog Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Proteins; Receptors, Notch; Signal Transduction; Spinal Cord; Superoxide Dismutase; Thiazoles; Zinc Finger Protein Gli2	2017
Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis. PloS one, 2010, May-13, Volume: 5, Issue:5 Topics: Amyloid; Amyotrophic Lateral Sclerosis; Animals; Benzothiazoles; Cell Death; Humans; Kinetics; Mice; Mice, Transgenic; Microscopy, Electron; Protein Stability; Spinal Cord; Subcellular Fractions; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Time Factors	2010
Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis. Neuroscience letters, 2011, Oct-10, Volume: 503, Issue:3 Topics: Amyotrophic Lateral Sclerosis; Annexin A5; Blotting, Western; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescent Antibody Technique; Humans; Mitochondria; Motor Neurons; Mutation; Neuroprotective Agents; Niacinamide; Propidium; Real-Time Polymerase Chain Reaction; Resveratrol; Sirtuin 1; Stilbenes; Superoxide Dismutase; Superoxide Dismutase-1; Tetrazolium Salts; Thiazoles; Up-Regulation	2011
The neuroprotective effect of the GSK-3β inhibitor and influence on the extrinsic apoptosis in the ALS transgenic mice. Journal of the neurological sciences, 2012, Sep-15, Volume: 320, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Caspase 8; Cell Count; Disease Models, Animal; fas Receptor; Fas-Associated Death Domain Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Mice, Transgenic; Motor Neurons; Neuroprotective Agents; Phosphorylation; Rotarod Performance Test; Signal Transduction; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Urea	2012
A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS. Free radical biology & medicine, 2012, Dec-01, Volume: 53, Issue:11 Topics: Acetamides; Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Antioxidant Response Elements; Apoptosis; Apoptosis Regulatory Proteins; Cell Survival; Drug Evaluation, Preclinical; Enzyme Induction; Enzyme Inhibitors; Female; Free Radical Scavengers; Gene Expression Regulation; Glutamate-Cysteine Ligase; HeLa Cells; Heme Oxygenase-1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lipid Peroxidation; Male; Metabolic Detoxication, Phase II; Mice; Mice, Transgenic; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Thiazoles	2012
c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis. PloS one, 2012, Volume: 7, Issue:9 Topics: Amyotrophic Lateral Sclerosis; Animals; Dasatinib; Disease Models, Animal; Mice; Motor Neurons; Phosphorylation; Proto-Oncogene Proteins c-abl; Pyrimidines; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles	2012
S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation. The Journal of biological chemistry, 2012, Dec-07, Volume: 287, Issue:50 Topics: Amyloid; Amyotrophic Lateral Sclerosis; Benzothiazoles; Calcium; Cell Cycle Proteins; Cell Line, Tumor; Humans; Kinetics; Protein Structure, Quaternary; Protein Structure, Secondary; S100 Calcium Binding Protein A6; S100 Proteins; Spectroscopy, Fourier Transform Infrared; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles	2012
Brain ¹⁸F-FDG and ¹¹C-PiB PET findings in two siblings with FTD/ALS associated with the C9ORF72 repeat expansion. Neurocase, 2014, Volume: 20, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Aniline Compounds; Brain; C9orf72 Protein; Diagnosis, Differential; DNA Repeat Expansion; Female; Fluorodeoxyglucose F18; Frontotemporal Dementia; Humans; Male; Middle Aged; Neurons; Positron-Emission Tomography; Proteins; Siblings; Thiazoles	2014
The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates. The Journal of biological chemistry, 2013, Mar-29, Volume: 288, Issue:13 Topics: Amino Acid Motifs; Amyloidogenic Proteins; Amyotrophic Lateral Sclerosis; Benzothiazoles; Chromatography; Circular Dichroism; Dimerization; DNA-Binding Proteins; DNA, Complementary; Frontotemporal Lobar Degeneration; Glutathione Transferase; Glycine; Humans; Neurodegenerative Diseases; Peptides; Protein Binding; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Scattering, Radiation; Thiazoles; X-Rays	2013
Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis. The Journal of biological chemistry, 2002, Dec-06, Volume: 277, Issue:49 Topics: Amino Acids; Amyotrophic Lateral Sclerosis; Benzothiazoles; Binding Sites; Chromatography, Liquid; Circular Dichroism; Erythrocytes; Humans; Hydrogen-Ion Concentration; Light; Microscopy, Atomic Force; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Neurons; Oxygen; Protein Binding; Protein Folding; Scattering, Radiation; Superoxide Dismutase; Thiazoles; Zinc	2002
Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine. Neurobiology of disease, 2003, Volume: 13, Issue:3 Topics: Acetylcysteine; Adenosine Triphosphate; Amyotrophic Lateral Sclerosis; Blotting, Western; Caspase 3; Caspases; Cell Death; DNA Fragmentation; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; L-Lactate Dehydrogenase; Mitochondria; Mutation; Neuroblastoma; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	2003
Low levels of ALS-linked Cu/Zn superoxide dismutase increase the production of reactive oxygen species and cause mitochondrial damage and death in motor neuron-like cells. Journal of the neurological sciences, 2005, May-15, Volume: 232, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Blotting, Western; Cell Death; Cell Division; Cell Line; Cell Proliferation; Cell Survival; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Humans; Membrane Potentials; Mitochondria; Motor Neurons; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Transfection	2005
Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS. Experimental neurology, 2007, Volume: 205, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Caspase 3; Cell Death; Cyclooxygenase 2; Cytochromes c; Cytosol; Disease Progression; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; In Situ Nick-End Labeling; Intercellular Adhesion Molecule-1; Mice; Mice, Transgenic; Motor Neurons; Poly(ADP-ribose) Polymerases; Postural Balance; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Urea	2007
Riluzole for amyotrophic lateral sclerosis. The Medical letter on drugs and therapeutics, 1995, Dec-08, Volume: 37, Issue:963 Topics: Amyotrophic Lateral Sclerosis; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Muscles; Riluzole; Sodium Channels; Thiazoles; Tracheostomy; Treatment Outcome	1995
From the Food and Drug Administration. JAMA, 1995, Jul-26, Volume: 274, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Drug Labeling; Drugs, Investigational; Humans; Product Surveillance, Postmarketing; Riluzole; Theophylline; Thiazoles; United States; United States Food and Drug Administration	1995
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Research Design; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Humans; Research Design; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Research Support as Topic; Riluzole; Thiazoles	1994
Neuroprotective effects of riluzole in ALS CSF toxicity. Neuroreport, 1994, Apr-14, Volume: 5, Issue:8 Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Humans; Neurons; Neurotoxins; Rats; Receptors, Glutamate; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1994
Riluzole for the treatment of amyotrophic lateral sclerosis--too soon to tell? The New England journal of medicine, 1994, Mar-03, Volume: 330, Issue:9 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1994
Riluzole and amyotrophic lateral sclerosis. Lancet (London, England), 1996, Aug-03, Volume: 348, Issue:9023 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Humans; Neuroprotective Agents; Patient Dropouts; Proportional Hazards Models; Reproducibility of Results; Riluzole; Risk; Thiazoles	1996
[Riluzole for everybody or for nobody]. Neurologia (Barcelona, Spain), 1996, Volume: 11, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1996
The impact of the approval of riluzole. Neurology, 1996, Volume: 47, Issue:4 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
Rilutek (Riluzole) may extend survival in amyotrophic lateral sclerosis. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 1996, Volume: 28, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Riluzole; Survival Analysis; Thiazoles; Tracheostomy	1996
Riluzole and amyotrophic lateral sclerosis: did potential market size bias pharmaceutical research? Archives of neurology, 1996, Volume: 53, Issue:11 Topics: Amyotrophic Lateral Sclerosis; Drug Industry; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
Riluzole. Lancet (London, England), 1996, Dec-14, Volume: 348, Issue:9042 Topics: Aged; Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Humans; Neuroprotective Agents; Publishing; Riluzole; Thiazoles	1996
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Annals of neurology, 1996, Volume: 39, Issue:2 Topics: Acetates; Amines; Amyotrophic Lateral Sclerosis; Animals; Brain; Cyclohexanecarboxylic Acids; Diet; Disease Progression; Gabapentin; gamma-Aminobutyric Acid; Humans; Mice; Mice, Transgenic; Oxidative Stress; Riluzole; Spinal Cord; Superoxide Dismutase; Survival Analysis; Thiazoles; Vitamin E	1996
[Riluzole treatment in amyotrophic lateral sclerosis]. Nederlands tijdschrift voor geneeskunde, 1996, Nov-16, Volume: 140, Issue:46 Topics: Amyotrophic Lateral Sclerosis; Controlled Clinical Trials as Topic; Drug Costs; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
[Neuroprotective therapy for amyotrophic lateral sclerosis (ALS)]. Rinsho shinkeigaku = Clinical neurology, 1996, Volume: 36, Issue:12 Topics: Amyotrophic Lateral Sclerosis; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
Amyotrophic lateral sclerosis: from pathological mechanisms to patient care. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Animals; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Point Mutation; Riluzole; Superoxide Dismutase; Thiazoles	1997
Riluzole--what is its impact in our treatment and understanding of amyotrophic lateral sclerosis? The Annals of pharmacotherapy, 1997, Volume: 31, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1997
Practice advisory on the treatment of amyotrophic lateral sclerosis with riluzole: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 1997, Volume: 49, Issue:3 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Humans; Neurology; Riluzole; Societies, Medical; Thiazoles; Treatment Outcome	1997