thiazoles has been researched along with Amyloid Deposits in 201 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (3.48) | 18.2507 |
| 2000's | 85 (42.29) | 29.6817 |
| 2010's | 104 (51.74) | 24.3611 |
| 2020's | 5 (2.49) | 2.80 |
| Authors | Studies |
|---|---|
| Aso, Y; Kimura, N; Matsubara, E | 1 |
| Allison, SL; Asthana, S; Betthauser, TJ; Carlsson, CM; Chin, NA; Christian, BT; Clark, LR; Cody, KA; Erickson, CM; Johnson, SC; Jonaitis, EM; Koscik, RL; Mueller, KD; Rowley, HA; Stone, CK | 1 |
| DeCarli, C; Farias, ST; Fletcher, E; Han, JW; Harvey, D; Jagust, W; Johnson, DK; Maillard, P; Martinez, O; Mungas, D; Olichney, JM; Villeneuve, S | 1 |
| Baker, SL; Boxer, A; DeCarli, C; Edwards, L; Gorno-Tempini, M; Grinberg, LT; Hepker, M; Huang, E; Hwang, JL; Iaccarino, L; Jagust, WJ; Janabi, M; La Joie, R; Lesman-Segev, OH; Lobach, I; Miller, BL; Olichney, J; Pham, J; Rabinovici, GD; Rosen, HJ; Seeley, WW; Seo, SW; Spina, S | 1 |
| Bateman, RJ; Benzinger, TLS; Cairns, NJ; Chen, CD; Chhatwal, J; Cruchaga, C; Franklin, EE; Friedrichsen, K; Ghetti, B; Goate, A; Gordon, B; Hornbeck, R; Jack, C; Joseph-Mathurin, N; Karch, C; Klunk, WE; Koeppe, R; Lashley, T; Li, Y; Masters, CL; McCullough, A; McDade, E; McLean, C; Morris, JC; Perrin, RJ; Ringman, JM; Sharma, V; Sinha, N; Su, Y; Xiong, C; Zhou, A | 1 |
| Byun, MS; Cho, HJ; Choe, YM; Han, SH; Jung, ES; Kang, S; Kim, EH; Kim, YK; Lee, DY; Mook-Jung, I; Park, JC; Won, SJ; Yi, D | 1 |
| Allémann, E; Dumoulin, M; Forge, V; Heinrich-Balard, L; Lux, F; Marquette, C; Morfin, JF; Pansieri, J; Plissonneau, M; Rivory, P; Saraiva, MJ; Stransky-Heilkron, N; Tillement, O; Toth, E | 1 |
| Bednarikova, Z; Gazova, Z; Huy, PDQ; Li, MS; Linh, HQ; Phuc, LH; Thai, NQ | 1 |
| Ackermann, M; Denver, P; Kelly, P; Konerding, MA; Mitchell, CA; Satchell, SC | 1 |
| Li, MH; Wang, PJ; Wu, JQ; Zeng, JQ | 1 |
| Bauckneht, M; Morbelli, S | 1 |
| Aakre, JA; Alhurani, R; Coloma, P; Geda, YE; Jack, CR; Knopman, DS; Kremers, WK; Lowe, VJ; Machulda, MM; Mielke, MM; Petersen, RC; Roberts, RO; Schauble, B; Vassilaki, M | 1 |
| Blennow, K; Bottelbergs, A; Haaparanta-Solin, M; Helin, S; Herukka, SK; Hiltunen, M; Jääskeläinen, JE; Johansson, J; Jokinen, P; Koivisto, AM; Kolb, HC; Leinonen, V; Okamura, N; Pemberton, D; Rauramaa, T; Rinne, JO; Rokka, J; Solin, O; Tesseur, I; van der Ark, P; Zetterberg, H | 1 |
| Cai, L; Gao, S; Ji, Y; Li, Y; Shi, Z; Wang, Y; Xing, X; Yang, H; Yao, S; Zhang, N | 1 |
| Chung, YH; Hsu, PH; Lin, KJ; Lin, YT; Liu, HL; Yang, LY; Yen, TC | 1 |
| Li, M; Wang, P; Wu, J; Zeng, J | 1 |
| Ayakta, N; Borys, E; Boxer, AL; DeCarli, C; Doré, V; Grinberg, LT; Huang, E; Hwang, JH; Ikonomovic, MD; Jack, C; Jagust, WJ; Jin, LW; Klunk, WE; Kofler, J; La Joie, R; Lesman-Segev, OH; Lockhart, SN; Lowe, VJ; Masters, CL; Mathis, CA; McLean, CL; Miller, BL; Mungas, D; Murray, ME; O'Neil, JP; Olichney, JM; Parisi, JE; Petersen, RC; Rabinovici, GD; Rosen, HJ; Rowe, CC; Seeley, WW; Spina, S; Vemuri, P; Villemagne, VL | 1 |
| Arbizu, J; Boada, M; Martínez-Lage, P; Monleón, I; Munuera, J; Pérez-Grijalba, V; Pesini, P; Romero, J; Ruiz, A; San-José, I; Sarasa, L; Sarasa, M; Tárraga, L | 1 |
| Bogie, J; Chintapakorn, Y; Cuypers, A; Dewachter, I; Groen, A; Hellings, N; Hendriks, J; Hoeks, C; Jonker, JW; Kerksiek, A; Leijten, F; Liu, HB; Lütjohann, D; Martinez-Martinez, P; Mulder, M; Pornpakakul, S; Schepers, M; Sijbrands, E; Staels, B; Struik, D; Suttiyut, T; Tiane, A; Vanmierlo, T; Walter, J | 1 |
| Scheltens, P; Teunissen, CE; Tijms, BM; van Paasen, AJL; Vermunt, L; Visser, PJ | 1 |
| Doi, S; Ishi, K; Kaida, H; Kashiwagi, N; Satou, T | 1 |
| Albertson, SM; Boeve, B; Dickson, DW; Jack, CR; Jones, DT; Kantarci, K; Knopman, D; Lowe, VJ; Lundt, ES; Murray, ME; Parisi, JE; Petersen, RC; Przybelski, SA; Senjem, ML | 1 |
| Bowie, CR; Brown, EE; Caravaggio, F; Fischer, CE; Flint, A; Gerretsen, P; Graff-Guerrero, A; Herrmann, N; Mah, L; Mulsant, BH; Pollock, BG; Rajji, TK; Rashidi-Ranjbar, N; Voineskos, AN | 1 |
| Fuchigami, T; Haratake, M; Mandai, M; Nakayama, M; Yoshida, S | 1 |
| Czisch, M; Drzezga, A; Grünecker, B; Henriksen, G; von Reutern, B; Yousefi, BH | 1 |
| Bennett, DA; Bradshaw, EM; Chibnik, LB; De Jager, PL; Evans, DA; Imboywa, S; Johnson, K; Keenan, BT; Lee, M; Morris, MC; Ottoboni, L; Raj, T; Rosenkrantz, LL; Schneider, JA; Sperling, RA; Tang, A; Von Korff, A | 1 |
| Brooks, DJ; Edison, P; Ikoma, Y; Ramlackhansingh, A; Turkheimer, FE | 1 |
| Benzinger, TL; Blazey, TM; Christensen, JJ; D'Angelo, GM; Marcus, DS; Mintun, MA; Morris, JC; Snyder, AZ; Su, Y; Vlassenko, AG; Vora, S; Zhou, G | 1 |
| Arakawa, R; Eguchi, Y; Fukumura, T; Higuchi, M; Ito, H; Kodaka, F; Miyoshi, M; Okamura, N; Ono, M; Shimada, H; Shinotoh, H; Suhara, T; Takahashi, H; Takano, H; Yanai, K | 1 |
| Antoni, G; Estrada, S; Hellström-Lindahl, E; Westermark, P | 1 |
| Geraldes, CF; Martins, AF; Morfin, JF; Tóth, E | 1 |
| Baumann, F; Bühler, A; Höflinger, P; Jeffrey, M; Jucker, M; McGovern, G; Nagarathinam, A; Schäfer, C; Staufenbiel, M | 1 |
| Miličević, A; Raos, N | 1 |
| Ames, D; Bourgeat, P; Dore, V; Ellis, KA; Fripp, J; Macaulay, SL; Masters, CL; Raniga, P; Rowe, CC; Salvado, O; Villemagne, VL; Zhou, L | 1 |
| Adriaanse, SM; Barkhof, F; Boellaard, R; Lammertsma, AA; Ossenkoppele, R; Reuter, M; Scheltens, P; Tolboom, N; van Berckel, BN; van der Flier, WM; van Dijk, KR; Windhorst, AD; Yaqub, M; Zwan, MD | 1 |
| Fodero-Tavoletti, MT; Furumoto, S; Harada, R; Kudo, Y; Masters, CL; Mulligan, RS; Okamura, N; Pejoska, S; Rowe, CC; Villemagne, VL; Yanai, K; Yates, P | 1 |
| Drzezga, A; Förster, S; Förstl, H; Göttler, J; Grimmer, T; Koch, K; Kurz, A; Mühlau, M; Myers, N; Neitzel, J; Ortner, M; Pasquini, L; Riedl, V; Sorg, C; Wohlschläger, AM; Zimmer, C | 1 |
| Furuta, A; Imagawa, H; Matsunaga, Y; Ouma, S; Suenaga, M; Takahashi, H; Tsuboi, Y; Wagatsuma, M | 1 |
| Baker, SL; Crowley, S; Elman, JA; Jagust, WJ; Madison, CM; Marks, SM; O'Neil, JP; Oh, H; Vogel, JW | 1 |
| Ames, D; Bourgeat, P; Brown, B; Dore, V; Ellis, K; Fripp, J; Macaulay, SL; Martins, R; Masters, CL; Rowe, CC; Salvado, O; Villemagne, VL | 1 |
| de Leon, M; Glodzik, L; Li, J; Li, Y; McHugh, P; Mosconi, L; Murray, J; Osorio, R; Pirraglia, E; Randall, C; Rusinek, H; Spector, N; Tsui, W; Vallabhajolusa, S; Williams, S; Zhou, C | 1 |
| Burnet, M; Calaminus, C; Garaschuk, O; Jucker, M; Lerdkrai, C; Maier, FC; Mannheim, JG; Pichler, BJ; Reischl, G; Sabri, O; Schmid, AM; Stahlschmidt, A; Staufenbiel, M; Stiller, D; Wehrl, HF; Wiehr, S; Ye, L | 1 |
| Benzinger, TL; Devous, MD; Jagust, WJ; Johnson, KA; Klunk, WE; Koeppe, RA; Mathis, CA; Minhas, D; Mintun, MA; Pontecorvo, MJ; Price, JC; Rowe, CC; Skovronsky, DM | 1 |
| Arzberger, T; Drzezga, A; Förster, S; Grimmer, T; Henriksen, G; Manook, A; Schwaiger, M; von Reutern, B; Wester, HJ; Yousefi, BH | 1 |
| Curtis, MA; Dragunow, M; Faull, R; Lill, C; Narayan, PJ | 1 |
| Bai, F; Beebe, DC; Bei, L; Nelson, SK; Shui, YB; Van Stavern, GP | 1 |
| Cannon, A; Dickson, DW; Duara, R; Graff-Radford, NR; Jack, CR; Kantarci, K; Knopman, DS; Liesinger, AM; Lowe, VJ; Murray, ME; Parisi, JE; Petersen, RC; Przybelski, SA; Rawal, B; Ross, OA | 1 |
| Goduni, E; Jay, T; Lamb, BT; Landreth, GE; Malm, T; Mariani, MM; Quigley, C; Ransohoff, RM; Savage, JC | 1 |
| Ashino, H; Bando, K; Chen, CJ; Farde, L; Higuchi, M; Ji, B; Kasahara, H; Minamizawa, T; Ono, M; Sano, H; Seki, C; Shiraishi, H; Suhara, T; Yamada, K; Zhang, MR | 1 |
| Hosokawa, C; Hosono, M; Hyodo, T; Ishii, K; Kimura, Y; Murakami, T; Sakaguchi, K; Shimamoto, K; Usami, K; Yamazoe, Y | 1 |
| Lahiri, DK; Paule, MG; Ray, B; Raymick, J; Sarkar, S; Schmued, L | 1 |
| Constantinescu, CC; Liang, C; Mirbolooki, MR; Mukherjee, J; Mukherjee, MT; Pan, ML; Patel, B; Patel, HH | 1 |
| Ances, BM; Benzinger, TLS; Brier, MR; Friedrichsen, KA; McCarthy, JE; Morris, JC; Stern, A; Su, Y; Vlassenko, AG | 1 |
| Choi, B; Crouzet, C; Lo, P; Vasilevko, V | 1 |
| Alberi, L; Alina Raio, N; Brai, E | 1 |
| Aita, K; Akamatsu, G; Ikari, Y; Nishida, H; Ohnishi, A; Sasaki, M; Senda, M; Yamamoto, Y | 1 |
| Imabayashi, E; Maikusa, N; Matsuda, H; Sasaki, K; Yuasa, T | 1 |
| Ashe, KH; Borchelt, DR; Forster, CL; Hemmy, LS; Huang, ES; Kuskowski, MA; Liu, P; McNellis, BM; Rao, ER; Reichl, JH; Vassar, R; Zahs, KR | 1 |
| Abrahamson, EE; Fish, KN; Ikonomovic, MD; Mi, Z; Mufson, EJ; Ryu, AY; Sweet, RA | 1 |
| Etienne, MA; Gordon, M; Hammer, RP; Li, Q; Morgan, D | 1 |
| Csernansky, JG; Deal, C; Dong, H; Mace, AG; Martin, MV; Yoo, HS; Yuede, CM | 1 |
| Becker, JT; DeKosky, ST; Hoge, JA; Klunk, WE; Lopresti, BJ; Mathis, CA; Price, JC; Raji, CA; Saxton, JA; Tsopelas, ND; Ziolko, SK | 1 |
| Beach, TG; Castaño, EM; Daugs, ID; Davis, J; Esh, CL; Kalback, WM; Kokjohn, TA; Lue, LF; Luehrs, DC; Patton, RL; Roher, AE; Van Nostrand, WE; Van Vickle, GD; Walker, DG | 1 |
| Levine, H; Walker, LC | 1 |
| Cuasay, K; Devanand, D; Gunn, R; Lai, RY; Libri, V; Mann, JJ; Mikhno, A; Parsey, RV; Pelton, G; Upton, N | 1 |
| Aalto, S; Alafuzoff, I; Jääskeläinen, JE; Leinonen, V; Någren, K; Pirttilä, T; Rinne, J; Rinne, JO; Savolainen, S; Soininen, H; Suotunen, T; Tapiola, T | 1 |
| Chávez-Macías, L; Harrington, CR; Luna-Muñoz, J; Mena, R; Peralta-Ramirez, J; Wischik, CM | 1 |
| Klunk, WE | 1 |
| Carroll, VL; Dickson, TC; Halliday, GM; King, AE; Shepherd, CE; Sokolova, A; Vickers, JC; Woodhouse, A | 1 |
| Beal, MF; Chen, HL; Gibson, GE; Karuppagounder, SS; Pinto, JT; Xu, H | 1 |
| Becker, JA; Frosch, MP; Garcia-Alloza, M; Grabowski, T; Greenberg, SM; Gurol, ME; Johnson, KA; Nandigam, RN; Prada, C; Rosand, J; Skehan, ME; Smith, EE; Viswanathan, A | 1 |
| DeKosky, ST; Klunk, WE; Lopresti, BJ; Mathis, CA; Price, J; Venneti, S; Wiley, CA | 1 |
| Farde, L; Jeppsson, F; Johnson, AE; Juréus, A; Neelissen, JA; Norman, H; Sandell, J; Ström, P; Svensson, SP; Wensbo, D | 1 |
| Bormans, G; Kung, H; Mortelmans, L; Serdons, K; Terwinghe, C; Van Laere, K; Verbruggen, A; Vermaelen, P | 1 |
| Caccialanza, G; Carotti, A; Catto, M; Colombo, R; De Lorenzi, E; Lanni, C; Racchi, M; Verga, L | 1 |
| Drzezga, A; Foerstl, H; Grimmer, T; Henriksen, G; Kurz, A; Miederer, I; Mühlau, M; Perneczky, R; Praus, C; Riemenschneider, M; Schwaiger, M; Sorg, C; Wester, HJ; Wohlschläger, A | 1 |
| Caroli, A; Frisoni, GB; Kemppainen, N; Lorenzi, M; Någren, K; Rinne, JO | 1 |
| Arai, H; Funaki, Y; Furukawa, K; Furumoto, S; Iwata, R; Kato, M; Kudo, Y; Okamura, N; Tashiro, M; Waragai, M; Yanai, K | 1 |
| Archer, HA; Brooks, DJ; Bullock, R; Edison, P; Fox, NC; Kennedy, A; Koivunen, J; Någren, K; Okello, A; Rinne, JO; Rossor, MN; Turkheimer, FE; Walker, Z | 1 |
| Bowles, N; Gaspar, RC; Hepler, RW; Joyce, JG; Shughrue, PJ; Villarreal, SA | 1 |
| Durany, N; Fernàndez-Busquets, X; Gella, A; Unzeta, M; Valente, T | 1 |
| Feinstein, DL; Kalinin, S; Richardson, JC | 1 |
| Bu, G; Crick, SL; Frieden, C; Hu, X; Lee, JM; Pappu, RV | 1 |
| Hattori, N; Ishii, K; Kambe, T; Motoi, Y | 1 |
| Arai, H; Furukawa, K; Furumoto, S; Iwata, R; Kudo, Y; Okamura, N; Tashiro, M; Waragai, M; Yanai, K | 1 |
| Arai, H; Doh-ura, K; Furukawa, K; Furumoto, S; Itoyama, Y; Iwata, R; Kudo, Y; Okamura, N; Shiga, Y; Tashiro, M; Tsuboi, Y; Yanai, K | 1 |
| Acosta, O; Ames, D; Bourgeat, P; Chételat, G; Ellis, KA; Fripp, J; Martins, RN; Masters, CL; Ourselin, S; Pike, K; Raniga, P; Rowe, CC; Salvado, O; Szoeke, C; Villemagne, VL | 1 |
| Lee, SY; Shin, J | 1 |
| An, Y; Davatzikos, C; Driscoll, I; Ferrucci, L; Klunk, WE; Kraut, MA; Mathis, CA; Resnick, SM; Sojkova, J; Wong, DF; Ye, W; Zhou, Y | 1 |
| Fagan, AM; Goate, AM; Holtzman, DM; Mintun, MA; Morris, JC; Roe, CM; Xiong, C | 1 |
| Haddix, T; Lee, VM; Nakashima-Yasuda, H; Robinson, J; Trojanowski, JQ; Uryu, K | 1 |
| Ames, D; Bourgeat, P; Chételat, G; Ellis, KA; Jones, G; Martins, RN; Masters, CL; O'Keefe, GJ; Pike, KE; Rowe, CC; Salvado, O; Szoeke, C; Villemagne, VL | 1 |
| Becker, JA; Buckner, RL; Eng, E; Johnson, KA; Locascio, JJ; Moran, EK; Rentz, DM; Sperling, RA | 1 |
| Cho, SJ; Kim, SH; Kim, SJ; Kim, YB; Lee, SY; Shin, J | 1 |
| Aznar, S; El-Sayed, M; Elvang, AB; Ettrup, A; Holm, P; Klein, AB; Knudsen, GM; Mikkelsen, JD; Santini, MA; Stensbøl, TB | 1 |
| Acosta, O; Ames, D; Bourgeat, P; Ellis, KA; Fripp, J; Head, R; Jones, G; Lenzo, N; Martins, R; Masters, CL; Morandeau, L; O'Keefe, G; Pike, KE; Price, R; Raniga, P; Rimajova, M; Robins, P; Rowe, CC; Salvado, O; Szoeke, C; Tochon-Danguy, H; Villemagne, VL | 1 |
| Alexopoulos, P; Drzezga, A; Förschler, A; Förstl, H; Grimmer, T; Henriksen, G; Klunk, WE; Kurz, A; Mathis, CA; Perneczky, R; Sorg, C; Tholen, S; Yousefi, BH | 1 |
| Demaerel, P; Dhollander, I; Nelissen, N; Peeters, D; Thijs, V; Van Laere, K; Van Paesschen, W; Vandenberghe, R | 1 |
| Arai, H; Fukuda, H; Furukawa, K; Furumoto, S; Iwata, R; Kudo, Y; Matsuda, H; Okamura, N; Shao, H; Sugi, K; Tashiro, M; Yanai, K | 1 |
| Huang, W; Lei, H; Wang, X; Xu, W; Zhan, Y; Zhang, S | 1 |
| Bartic, C; Benilova, I; Braeken, D; Broersen, K; Callewaert, G; D'Hooge, R; De Strooper, B; Debulpaep, M; Jonckheere, W; Kuperstein, I; Martins, IC; Rousseau, F; Rozenski, J; Schymkowitz, J; Segers-Nolten, I; Subramaniam, V; Van Der Werf, K; Vandersteen, A | 1 |
| Castellani, RJ; Rolston, RK; Smith, MA | 1 |
| Appelt, DM; Balin, BJ; Hallock, LR; Hammond, CJ; Howanski, RJ; Little, CS | 1 |
| Almkvist, O; Darreh-Shori, T; Gonzalez, D; Kadir, A; Marutle, A; Mousavi, M; Mustafiz, T; Nennesmo, I; Nordberg, A; Schöll, M | 1 |
| Benzinger, T; D'Angelo, G; Dixit, S; Fagan, A; Goate, A; Liu, C; Mintun, MA; Morris, JC; Price, JL; Sheline, YI; Snyder, AZ; Yan, Z | 1 |
| Borbon, IA; Erickson, RP | 1 |
| Ackermann, U; Ames, D; Bourgeat, P; Chételat, G; Ellis, KA; Jones, G; Klunk, WE; Martins, R; Masters, CL; Mathis, CA; Mulligan, RS; O'Keefe, G; Pike, KE; Rowe, CC; Salvado, O; Szoeke, C; Villemagne, VL | 1 |
| Fukumura, T; Hattori, S; Higuchi, M; Iwata, N; Ji, B; Kumata, K; Lee, VM; Maeda, J; Mori, H; Okauchi, T; Ono, M; Saido, TC; Staufenbiel, M; Suhara, T; Tomiyama, T; Trojanowski, JQ; Zhang, MR | 1 |
| Dudczak, R; Haeusler, D; Mitterhauser, M; Philippe, C; Ungersboeck, J; Viernstein, H; Wadsak, W | 1 |
| Ansciaux, E; Burtea, C; Larbanoix, L; Laurent, S; Mahieu, I; Muller, RN; Vander Elst, L | 1 |
| Arnold, SE; Buckley, C; Grachev, ID; Grady, MS; Hamilton, RH; Kazi, H; McLain, R; Sherwin, P; Trojanowski, JQ; Wolk, DA | 1 |
| Jagust, WJ | 1 |
| Georgopoulos, S; Katsouri, L | 1 |
| Chamberlain, R; Curran, GL; Garwood, M; Hultman, KL; Jack, CR; Marjańska, M; Poduslo, JF; Preboske, GM; Wengenack, TM | 1 |
| Arai, H; Fukuda, H; Furukawa, K; Furumoto, S; Iwata, R; Kaneta, T; Kudo, Y; Minoshima, S; Okamura, N; Takahashi, S; Tashiro, M; Yanai, K | 1 |
| Cho, JY; Heo, J; Hong, S; Jung, G; Lee, SJ; Ryu, J | 1 |
| Ataka, S; Miki, T; Mori, H; Shimada, H; Takechi, H; Tomiyama, T | 1 |
| Bateman, RJ; Duntley, S; Huang, Y; Ju, YE; Kasten, T; Mintun, M; Morris, JC; Potter, R; Santacruz, A; Shih, S; Sigurdson, W | 1 |
| Combs, CK; Dhawan, G; Floden, AM | 1 |
| Benzinger, TL; Goate, AM; Mintun, MA; Morris, JC; Sheline, YI; Vlassenko, AG; Xiong, C | 1 |
| Abrahamson, EE; Cohen, AD; Debnath, ML; DeKosky, ST; Hamilton, RL; Ikonomovic, MD; Klunk, WE; Lopez, OL; Mathis, CA; Mizukami, K; Paljug, WR; Price, JC | 1 |
| Drzezga, A; Henriksen, G; Huisman, M; Manook, A; Neff, F; Platzer, S; Reder, S; Schoor, M; Schwaiger, M; Settles, M; Velden, J; von der Kammer, H; Voss, A; Wester, HJ; Willuweit, A; Yousefi, BH | 1 |
| Brooks, DJ; Gelosa, G | 1 |
| Ikeda, T; Ono, K; Takahashi, R; Yamada, M | 1 |
| Arnold, SE; Boudhar, S; Clark, CM; Pontecorvo, MJ; Wolk, DA; Zhang, Z | 1 |
| Davatzikos, C; Driscoll, I; Ferrucci, L; Klunk, WE; Kraut, MA; Mathis, CA; O'Brien, RJ; Pletnikova, O; Resnick, SM; Rudow, G; Sojkova, J; Troncoso, JC; Wong, DF; Zhou, Y | 1 |
| Beker, S; Kellner, V; Kerti, L; Stern, EA | 1 |
| Baig, I; Beckett, TL; Keller, JN; Kryscio, RJ; LeVine, H; Matveev, S; Mendiondo, MS; Murphy, MP; Niedowicz, DM; Weidner, AM | 1 |
| Arai, H; Furukawa, K; Furumoto, S; Harada, R; Ishikawa, Y; Iwata, R; Kudo, Y; Okamura, N; Sugi, K; Tago, T; Tashiro, M; Tomita, N; Waragai, M; Yanai, K | 1 |
| Buckley, C; Eskola, O; Farrar, G; Grachev, ID; Heurling, K; Huttunen, J; Jääskeläinen, JE; Jones, PA; Kailajärvi, M; Koivisto, AM; Leinonen, V; McLain, R; Nerg, O; Rinne, J; Rinne, JO; Rummukainen, J; Sherwin, P; Smith, A; Virtanen, KA; von Und Zu Fraunberg, M | 1 |
| Aronow, BJ; Bales, KR; DeMattos, RB; Harmony, JA; Holtzman, DM; O'dell, MA; Parsadanian, M; Paul, SM; Taylor, JW | 1 |
| Bacskai, BJ; Games, D; Hyman, BT; Kajdasz, ST; McLellan, ME; Schenk, D; Seubert, P | 1 |
| Capsoni, S; Cattaneo, A; Giannotta, S | 1 |
| Ashe, KH; Cruz, L; Duff, K; Hyman, BT; Irizarry, MC; Le, R; Sanders, J; Stanley, HE; Urbanc, B | 1 |
| Hou, C; Kung, HF; Kung, MP; Lee, VM; Skovronsky, D; Trojanowski, JQ; Zhang, B; Zhuang, ZP | 1 |
| Borowski, BJ; Curran, GL; Jack, CR; Macura, SI; Poduslo, JF; Sigurdsson, EM; Wengenack, TM; Wisniewski, T | 1 |
| Bacskai, BJ; D'Amore, JD; Hyman, BT; Kajdasz, ST; McLellan, ME; Stern, EA | 1 |
| Ban, T; Goto, Y; Hamada, D; Hasegawa, K; Naiki, H | 1 |
| Bacskai, BJ; Hyman, BT; Kajdasz, ST; McLellan, ME | 1 |
| Gur, TL; Hou, C; Kung, HF; Kung, MP; Lee, VM; Skovronsky, DM; Trojanowski, JQ; Zhang, B; Zhuang, ZP | 1 |
| Dickson, TC; Tan, A; Vickers, JC | 1 |
| Clarke, K; DiCarlo, G; Gordon, MN; Henderson, D; Jackson, J; Morgan, D; Ugen, KE; Wilcock, DM | 1 |
| Hou, C; Jin, LW; Kung, HF; Kung, MP; Zhuang, ZP | 1 |
| Debnath, ML; Holt, DP; Huang, GF; Klunk, WE; Mathis, CA; Shao, L; Wang, Y | 2 |
| Bacskai, BJ; Hickey, GA; Huang, GF; Hyman, BT; Kajdasz, ST; Klunk, WE; Mathis, CA; Skoch, J; Wang, Y | 1 |
| Akatsu, H; Kudo, Y; Okamura, N; Sawada, T; Shimadzu, H; Shiomitsu, T; Suemoto, T; Suzuki, M; Yamamoto, T | 1 |
| Czilli, DL; DeMattos, RB; Gitter, B; Holtzman, DM; Kowalewski, T; Legleiter, J | 1 |
| Fonseca, MI; Kawas, CH; Tenner, AJ; Troncoso, JC | 1 |
| Emadi, S; Goud, G; Liu, R; Lyubchenko, Y; McAllister, C; Schulz, P; Sierks, MR; Yuan, B; Zameer, A | 1 |
| Dudal, S; Gervais, F; Krzywkowski, P; Lacombe, D; Morissette, C; Paquette, J; Tremblay, P | 1 |
| Duff, K; Hashimoto, T; Iwatsubo, T; Kowa, H; Mann, DM; Matsuura, Y; Sakakura, T; Tsuji, S; Wakabayashi, T | 1 |
| Barbour, R; Bard, F; Bussière, T; Buttini, M; Games, D; Grajeda, H; Guido, T; Khan, K; Schenk, D; Seubert, P | 1 |
| Chang, L; De Felice, FG; Ferreira, ST; Figueroa-Villar, JD; Garcia-Abreu, J; Klein, WL; Liu, R; Saraiva, LM; Vieira, MN | 1 |
| Ambegaokar, SS; Begum, AN; Chen, PP; Cole, GM; Frautschy, SA; Glabe, CG; Kayed, R; Lim, GP; Simmons, MR; Ubeda, OJ; Yang, F | 1 |
| Arendt, T; Brückner, MK; Gärtner, U; Gebhardt, R; Gruschka, H; Seeger, G; Ueberham, E; Ueberham, U | 1 |
| Beard, J; Das, P; DeLucia, M; Dickson, DW; Dolios, G; Eckman, CB; Eriksen, J; Golde, T; Hardy, J; Hutton, M; Jansen, K; Kim, J; Lin, WL; McGowan, E; Murphy, MP; Onstead, L; Pickford, F; Skipper, L; Wang, R; Yu, C | 1 |
| Bélanger, MJ; John Mann, J; Kumar, JS; Parsey, RV; Pratap, M; Simpson, NR; Sokol, LO; Van Heertum, RL; Wang, T | 1 |
| Iwasa, K; Matsumoto, Y; Naiki, H; Noguchi, M; Ono, K; Yamada, M; Yanase, D | 1 |
| Adriany, G; Borowski, BJ; Curran, GL; Garwood, M; Holasek, SS; Jack, CR; Lin, J; Poduslo, JF; Preboske, GM; Reyes, DA; Wengenack, TM | 1 |
| Baglioni, S; Bagnoli, S; Cecchi, C; Fiorillo, C; Liguri, G; Nacmias, B; Nosi, D; Pensalfini, A; Relini, A; Sorbi, S | 1 |
| Cai, L; Pike, VW; Wang, Y; Wei, J; Wu, C | 1 |
| Kudo, Y | 1 |
| Bourhim, M; Kruzel, M; Nicotera, T; Srikrishnan, T | 1 |
| Johne, R; Reimers, C; Schliebs, R; Seeger, J; Stahl, T | 1 |
| Christen, Y; Garneau, P; Longpré, F; Ramassamy, C | 1 |
| Fukuda, H; Okamura, N | 1 |
| Ono, M | 1 |
| Bojsen-Møller, M; Braendgaard, H; Frangione, B; Ghiso, J; Holton, J; Lashley, T; Meyerson, J; Ng, D; Plant, G; Revesz, T; Rostagno, A | 1 |
| Aalto, S; Brück, A; Helin, S; Kailajärvi, M; Kemppainen, NM; Någren, K; Oikonen, V; Parkkola, R; Rinne, JO; Scheinin, M; Viitanen, M; Wilson, IA | 1 |
| Almkvist, O; Blomquist, G; Engler, H; Forsberg, A; Hagman, G; Långström, B; Nordberg, A; Ringheim, A; Wall, A | 1 |
| Akagi, T; Takashima, A; Yoshiike, Y | 1 |
| Beach, TG; Brune, D; Esh, CL; Fifield, FG; Fraser, PE; Kalback, WM; Kokjohn, TA; Lopez, J; Luehrs, DC; McLaurin, J; Newel, AJ; Patton, RL; Poston, M; Roher, AE; Van Vickle, GD; Westaway, D | 1 |
| Austin, CP; Honson, NS; Huang, W; Inglese, J; Johnson, RL; Kuret, J | 1 |
| DeKosky, S; Diehl-Schmid, J; Drzezga, A; Grimmer, T; Henriksen, G; Klunk, WE; Kurz, A; Mathis, CA; Perneczky, R; Price, J; Schwaiger, M; Stangier, I; Wester, HJ | 1 |
| Aalto, S; Karrasch, M; Kemppainen, NM; Någren, K; Oikonen, V; Parkkola, R; Rinne, JO; Savisto, N; Viitanen, M | 1 |
| Ishii, K; Ishiwata, K; Kimura, Y; Mishina, M; Naganawa, M; Oda, K; Yanagisawa, M; Yano, J | 1 |
| Abrahamson, EE; Bi, W; Debnath, ML; DeKosky, ST; Hamilton, RL; Hope, CE; Ikonomovic, MD; Isanski, BA; Klunk, WE; Lopresti, BJ; Mathis, CA; Paljug, WR; Price, JC; Tsopelas, ND; Ziolko, S | 1 |
| Lyketsos, CG; Mielke, MM; Rosenberg, PB; Szekely, CA; Zandi, PP | 1 |
| Guillozet, AL; Mash, DC; Mesulam, MM; Smiley, JF | 1 |
| Crutcher, KA; Joshi, SN | 1 |
| Crutcher, KA; Scott, SA; Tolar, M | 1 |
| Alvarez, A; Bronfman, FC; Inestrosa, NC; Morgan, C | 1 |
| Geula, C; Mesulam, MM; Saroff, DM; Wu, CK | 1 |
| Dickson, DW; Lee, VM; Trojanowski, JQ; Wang, J | 1 |
| Boelens, WC; Bosman, GJ; de Jong, WW; Overkamp, PS; Reijnen-Aalbers, A; Renkawek, K; Stege, GJ; van Rijk, AF; Verschuure, P | 1 |
| Bales, KR; Fagan, AM; Holtzman, DM; Mackey, B; McKeel, D; Olney, J; Parsadanian, M; Paul, SM; Sartorius, LJ; Tenkova, T; Wozniak, D | 1 |
| Isobe, I; Michikawa, M; Yanagisawa, K | 1 |
| Chu, CC; Parvizi, J; Van Hoesen, GW | 1 |
| Dagø, L; Olesen, OF | 1 |
| Hamilton, RL; Klunk, WE; Styren, GC; Styren, SD | 1 |
| Bacskai, BJ; Christie, RH; Hyman, BT; Kajdasz, ST; Webb, WW; Williams, RM; Zipfel, WR | 1 |
| Azizeh, BY; Cotman, CW; Cribbs, DH; Head, E; Lott, IT; Tenner, AJ | 1 |
| Bales, KR; Cummins, DJ; DeLong, CA; Esterman, MA; Fishman, CE; Hanson, JC; Jordan, WH; Paul, SM; White, SL | 1 |
| Dickson, TC; Vickers, JC | 1 |
| Cruz, L; Duff, K; Hsiao-Ashe, K; Hyman, BT; Irizarry, MC; Knowles, RB; Le, R; Stanley, HE; Urbanc, B | 1 |
| Emson, PC; Iritani, S; Niizato, K | 1 |
| Borowska-Lehman, J; Gross, M; Izycka-Swieszewska, E; Rzepko, R; Zółtowska, A | 1 |
| Mallory, M; Mante, M; Masliaha, E; Rockenstein, E; Sisk, A | 1 |
| Bacskai, BJ; Debnath, ML; Frosch, MP; Holt, DP; Huang, GF; Hyman, BT; Kajdasz, ST; Klunk, WE; Mathis, CA; McLellan, ME; Wang, Y | 1 |
| Geula, C; Nagykery, N; Wu, CK | 1 |
5 review(s) available for thiazoles and Amyloid Deposits
| Article | Year |
|---|---|
Alzheimer disease.
Topics: Age Distribution; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antioxidants; Biomarkers; Brain; Cerebral Amyloid Angiopathy; Cholinergic Agents; Dementia; Diagnosis, Differential; Diet, Mediterranean; Estrogen Replacement Therapy; Global Health; Humans; Immunotherapy; Incidence; Mutation; Nerve Growth Factors; Neurofibrillary Tangles; Plaque, Amyloid; Positron-Emission Tomography; Prevalence; Risk Factors; tau Proteins; Thiazoles; Treatment Outcome | 2010 |
The prognostic value of amyloid imaging.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Cognitive Dysfunction; Humans; Plaque, Amyloid; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Stilbenes; Thiazoles | 2012 |
[Introduction to and general remarks on molecular imaging].
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzoxazoles; Brain; Carbon Radioisotopes; Diagnostic Imaging; Humans; Mice; Molecular Probes; Piperidines; Plaque, Amyloid; Positron-Emission Tomography; Propionates; Thiazoles | 2007 |
[Molecular imaging of beta-amyloid plaques in the brain].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Brain; Congo Red; Humans; Mice; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2007 |
Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies.
Topics: Alzheimer Disease; Aniline Compounds; Biomarkers; Biomarkers, Pharmacological; Brain; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Disease Progression; Drug Design; Humans; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Psychotropic Drugs; Radioligand Assay; Thiazoles | 2008 |
3 trial(s) available for thiazoles and Amyloid Deposits
| Article | Year |
|---|---|
Voxel-based analysis of 11C-PIB scans for diagnosing Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Female; Humans; Magnetic Resonance Imaging; Male; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2008 |
In vivo detection of prion amyloid plaques using [(11)C]BF-227 PET.
Topics: Adult; Aged; Aged, 80 and over; Autoradiography; Benzoxazoles; Brain; Carbon Radioisotopes; Case-Control Studies; Female; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Prion Diseases; Prions; Thiazoles | 2010 |
A modified method of 3D-SSP analysis for amyloid PET imaging using [¹¹C]BF-227.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzoxazoles; Carbon Radioisotopes; Case-Control Studies; Cognitive Dysfunction; Female; Humans; Imaging, Three-Dimensional; Male; Plaque, Amyloid; Positron-Emission Tomography; Reference Standards; Thiazoles | 2011 |
193 other study(ies) available for thiazoles and Amyloid Deposits
| Article | Year |
|---|---|
Novel Serum Biomarkers of Neurovascular Unit Associated with Cortical Amyloid Deposition.
Topics: Adenosine Triphosphate; Aged; Alzheimer Disease; Aniline Compounds; Biological Transport; Biomarkers; Cognitive Dysfunction; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2021 |
Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Carbon Radioisotopes; Cognitive Dysfunction; Female; Fluorine Radioisotopes; Humans; Isoquinolines; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neurofibrillary Tangles; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Prodromal Symptoms; tau Proteins; Thiazoles | 2020 |
Association of vascular brain injury, neurodegeneration, amyloid, and cognitive trajectory.
Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Aniline Compounds; Brain; Cerebrovascular Disorders; Cognition; Cognitive Dysfunction; Disease Progression; Executive Function; Female; Hippocampus; Humans; Independent Living; Magnetic Resonance Imaging; Male; Memory Disorders; Memory, Episodic; Neuropsychological Tests; Organ Size; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles; White Matter | 2020 |
Diagnostic Accuracy of Amyloid versus
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Brain; DNA-Binding Proteins; Female; Fluorodeoxyglucose F18; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Humans; Male; Middle Aged; Pick Disease of the Brain; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Sensitivity and Specificity; tau Proteins; Thiazoles | 2021 |
Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cohort Studies; Female; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2021 |
Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Cognitive Dysfunction; Cross-Sectional Studies; Female; Humans; Male; Peptide Fragments; Plaque, Amyloid; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Thiazoles | 2017 |
Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Diabetes Mellitus, Type 2; Gadolinium; Humans; Immunohistochemistry; Islet Amyloid Polypeptide; Mice; Multimodal Imaging; Nanoparticles; Plaque, Amyloid; Single-Domain Antibodies; Thiazoles | 2017 |
Bexarotene Does Not Clear Amyloid Beta Plaques but Delays Fibril Growth: Molecular Mechanisms.
Topics: Amyloid beta-Peptides; Benzothiazoles; Bexarotene; Dose-Response Relationship, Drug; Humans; Kinetics; Microscopy, Atomic Force; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Neuroprotective Agents; Plaque, Amyloid; Protein Multimerization; Protein Structure, Secondary; Tetrahydronaphthalenes; Thiazoles; Water | 2017 |
Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Capillaries; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Exploratory Behavior; Intussusception; Kidney Glomerulus; Liver; Male; Memory, Short-Term; Mice, Transgenic; Microvessels; Plaque, Amyloid; Spleen; Thiazoles | 2017 |
[
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Dogs; Humans; Magnetite Nanoparticles; Mice; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2017 |
Amyloid PET Imaging: Standardization and Integration with Other Alzheimer's Disease Biomarkers.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Carbon Radioisotopes; Fluorodeoxyglucose F18; Humans; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Stilbenes; Thiazoles | 2018 |
Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Asymptomatic Diseases; Brain; Case-Control Studies; Cognitive Dysfunction; Female; Humans; Longitudinal Studies; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Prevalence; Proportional Hazards Models; Prospective Studies; Thiazoles; United States | 2018 |
S-[18F]THK-5117-PET and [11C]PIB-PET Imaging in Idiopathic Normal Pressure Hydrocephalus in Relation to Confirmed Amyloid-β Plaques and Tau in Brain Biopsies.
Topics: Aged; Aged, 80 and over; Aniline Compounds; Brain; Brain Mapping; Female; Humans; Hydrocephalus, Normal Pressure; Magnetic Resonance Imaging; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Quinolines; tau Proteins; Thiazoles | 2018 |
Spatial Patterns of Hypometabolism and Amyloid Deposition in Variants of Alzheimer's Disease Corresponding to Brain Networks: a Prospective Cohort Study.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain; Brain Diseases, Metabolic; Carbon Radioisotopes; Case-Control Studies; Cohort Studies; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles; Time Factors; Tissue Distribution | 2019 |
Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhances GSK-3 Inhibitor Delivery for Amyloid-Beta Plaque Reduction.
Topics: Amyloid beta-Peptides; Animals; Biomarkers; Blood-Brain Barrier; Brain; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Immunohistochemistry; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Protein Aggregates; Protein Aggregation, Pathological; Protein Binding; Thiazoles; Ultrasonic Waves; Urea | 2018 |
A Novel Magnetic Nanoparticle for Early Detection of Amyloid Plaques in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Cell Line; Disease Models, Animal; Dogs; Early Diagnosis; Female; Humans; Immunohistochemistry; Madin Darby Canine Kidney Cells; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Positron-Emission Tomography; Surface-Active Agents; Thiazoles | 2018 |
Multisite study of the relationships between antemortem [
Topics: Aged; Alzheimer Disease; Aniline Compounds; Autopsy; Female; Humans; Male; Neuropathology; Plaque, Amyloid; Positron-Emission Tomography; Retrospective Studies; Thiazoles | 2019 |
Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer's Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Biomarkers; Case-Control Studies; Cognitive Dysfunction; Cross-Sectional Studies; Early Diagnosis; Female; Fluorodeoxyglucose F18; Genotype; Humans; Male; Neuroimaging; Peptide Fragments; Phosphorylation; Plaque, Amyloid; Positron-Emission Tomography; Prodromal Symptoms; tau Proteins; Thiazoles | 2019 |
Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Astrocytes; Cognition; Culture Media, Conditioned; Disease Models, Animal; Gene Expression Regulation; Genes, Reporter; Hippocampus; Humans; Liver X Receptors; Luciferases; Male; Memory, Short-Term; Mice; Mice, Transgenic; Microglia; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Sargassum; Signal Transduction; Stigmasterol; Thiazoles | 2019 |
Alzheimer disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Cognitive Dysfunction; Dementia; Disease Progression; Ethylene Glycols; Female; Humans; Male; Middle Aged; Peptide Fragments; Plaque, Amyloid; Positron-Emission Tomography; Prognosis; Recurrence; Remission, Spontaneous; Risk Assessment; tau Proteins; Thiazoles | 2019 |
Pittsburgh Compound-B Uptake in Meningioma With Histopathologic Correlation.
Topics: Aged, 80 and over; Aniline Compounds; Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Meningeal Neoplasms; Meningioma; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2019 |
Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Autopsy; Brain; Female; Fluorine Radioisotopes; Humans; Magnetic Resonance Imaging; Male; Neurodegenerative Diseases; Neurofibrillary Tangles; Neuroimaging; Neuropathology; Plaque, Amyloid; Positron-Emission Tomography; Prospective Studies; Thiazoles | 2019 |
Brain Amyloid PET Tracer Delivery is Related to White Matter Integrity in Patients with Mild Cognitive Impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain; Cerebrovascular Circulation; Cognitive Dysfunction; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles; White Matter | 2019 |
Elevated amyloid-β plaque deposition in dietary selenium-deficient Tg2576 transgenic mice.
Topics: Animals; Benzothiazoles; Brain; Diet; Feeding Behavior; Female; Fluorescence; Image Processing, Computer-Assisted; Mice; Mice, Transgenic; Plaque, Amyloid; Selenium; Thiazoles; Tissue Distribution | 2013 |
Voxel-based analysis of amyloid-burden measured with [(11)C]PiB PET in a double transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Animals; Benzothiazoles; Carbon Radioisotopes; Disease Models, Animal; Female; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Positron-Emission Tomography; Regression Analysis; Signal Processing, Computer-Assisted; Thiazoles | 2013 |
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Cognitive Dysfunction; Cohort Studies; Dextrans; Female; Genetic Association Studies; Genotype; HLA-D Antigens; Humans; Male; Microglia; Middle Aged; Monocytes; Peptide Fragments; Plaque, Amyloid; Polymorphism, Genetic; Radionuclide Imaging; Sialic Acid Binding Ig-like Lectin 3; Thiazoles; Young Adult | 2013 |
Reference region automatic extraction in dynamic [(11)C]PIB.
Topics: Algorithms; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Case-Control Studies; Cerebellum; Cluster Analysis; Humans; Plaque, Amyloid; Positron-Emission Tomography; Prefrontal Cortex; Reference Values; Reproducibility of Results; Thiazoles; Tissue Distribution | 2013 |
Quantitative analysis of PiB-PET with FreeSurfer ROIs.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Case-Control Studies; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Software; Thiazoles | 2013 |
Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT: comparison with [11C]PIB.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Benzoxazoles; Brain; Case-Control Studies; Cognitive Dysfunction; Female; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tissue Distribution | 2014 |
In vitro binding of [³H]PIB to human amyloid deposits of different types.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Case-Control Studies; Humans; Immunoglobulin Light Chains; Middle Aged; Plaque, Amyloid; Prealbumin; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Serum Amyloid A Protein; Thiazoles; Tissue Extracts; Tritium | 2014 |
Gd(3+) complexes conjugated to Pittsburgh compound B: potential MRI markers of β-amyloid plaques.
Topics: Amyloid beta-Peptides; Aniline Compounds; Blood-Brain Barrier; Gadolinium; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Magnetic Resonance Imaging; Micelles; Organometallic Compounds; Peptide Fragments; Permeability; Plaque, Amyloid; Serum Albumin; Thiazoles; Water | 2014 |
Membrane-anchored Aβ accelerates amyloid formation and exacerbates amyloid-associated toxicity in mice.
Topics: Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Blotting, Western; Cell Membrane; Endopeptidase K; Fluorescent Dyes; HEK293 Cells; Humans; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Phosphatidylinositols; Plaque, Amyloid; Thiazoles; Type C Phospholipases | 2013 |
Comparison of two methods for the estimation of stability of copper(II) bis-complexes with aromatic ligands relevant to Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Copper; Humans; Ligands; Organometallic Compounds; Plaque, Amyloid; Regression Analysis; Thiazoles | 2013 |
MR-less surface-based amyloid assessment based on 11C PiB PET.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Reproducibility of Results; Thiazoles | 2014 |
The effect of amyloid pathology and glucose metabolism on cortical volume loss over time in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Cerebral Cortex; Female; Fluorodeoxyglucose F18; Glucose; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2014 |
Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain Mapping; Carbon Radioisotopes; Female; Humans; Male; Neurofibrillary Tangles; Plaque, Amyloid; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; Thiazoles | 2014 |
Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Brain; Brain Mapping; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2014 |
Different effect of vitamin D2 and vitamin D3 on amyloid-β40 aggregation in vitro.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cholecalciferol; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ergocalciferols; Humans; In Vitro Techniques; Microscopy, Electron; Models, Chemical; Molecular Docking Simulation; Peptide Fragments; Plaque, Amyloid; Protein Interaction Mapping; Quartz Crystal Microbalance Techniques; Thiazoles; Time Factors | 2014 |
Neural compensation in older people with brain amyloid-β deposition.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aniline Compounds; Brain; Brain Mapping; Cognition; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Memory; Oxygen; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles; Young Adult | 2014 |
Comparison of MR-less PiB SUVR quantification methods.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Gray Matter; Humans; Magnetic Resonance Imaging; Neuroimaging; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2015 |
Reduced retention of Pittsburgh compound B in white matter lesions.
Topics: Aged; Aniline Compounds; Brain; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; White Matter | 2015 |
Longitudinal PET-MRI reveals β-amyloid deposition and rCBF dynamics and connects vascular amyloidosis to quantitative loss of perfusion.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Benzothiazoles; Brain; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; Female; Longitudinal Studies; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Multimodal Imaging; Perfusion Imaging; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2014 |
The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Calibration; Fluorodeoxyglucose F18; Humans; Image Interpretation, Computer-Assisted; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2015 |
Characterization and first human investigation of FIBT, a novel fluorinated Aβ plaque neuroimaging PET radioligand.
Topics: Aged; Aged, 80 and over; Aniline Compounds; Animals; Autoradiography; Benzothiazoles; Brain; Carbon Isotopes; Fluorodeoxyglucose F18; Humans; Imidazoles; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Rats; Thiazoles; Tissue Distribution | 2015 |
Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain.
Topics: Aged; Alzheimer Disease; Amyloid; Benzothiazoles; Blotting, Western; Brain; Cell Line, Tumor; Female; Fluorescent Antibody Technique; Histones; Humans; Male; Neurofibrillary Tangles; Plaque, Amyloid; tau Proteins; Thiazoles; Tissue Array Analysis; Ubiquitin | 2015 |
A test of lens opacity as an indicator of preclinical Alzheimer Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Asymptomatic Diseases; Biomarkers; Carbon Radioisotopes; Cataract; Densitometry; Female; Humans; Lens, Crystalline; Light; Male; Peptide Fragments; Plaque, Amyloid; Positron-Emission Tomography; Risk Assessment; Scattering, Radiation; Thiazoles | 2015 |
Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Female; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2015 |
Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Axl Receptor Tyrosine Kinase; Benzoates; Benzylamines; Bexarotene; c-Mer Tyrosine Kinase; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Leukocyte Common Antigens; Macrophages; Male; Membrane Glycoproteins; Mice; Microglia; Myeloid Cells; Phagocytosis; Pioglitazone; Plaque, Amyloid; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones | 2015 |
Distinct binding of amyloid imaging ligands to unique amyloid-β deposited in the presubiculum of Alzheimer's disease.
Topics: Alzheimer Disease; Aminopyridines; Amyloidogenic Proteins; Aniline Compounds; Autoradiography; Benzothiazoles; Humans; Imidazoles; In Vitro Techniques; Parahippocampal Gyrus; Plaque, Amyloid; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Receptors, GABA; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2015 |
Performance of 11C-Pittsburgh Compound B PET Binding Potential Images in the Detection of Amyloid Deposits on Equivocal Static Images.
Topics: Aged; Aged, 80 and over; Aniline Compounds; Cerebral Cortex; Cognition Disorders; Cognitive Dysfunction; Female; Gray Matter; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; White Matter | 2015 |
Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Benzothiazoles; Brain; Disease Models, Animal; Female; Male; Mice, Transgenic; Microglia; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2015 |
Evaluation of [11C]TAZA for amyloid β plaque imaging in postmortem human Alzheimer's disease brain region and whole body distribution in rodent PET/CT.
Topics: Alzheimer Disease; Aniline Compounds; Animals; Benzothiazoles; Hippocampus; Humans; Male; Multimodal Imaging; p-Dimethylaminoazobenzene; Plaque, Amyloid; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Species Specificity; Thiazoles; Tissue Distribution; Tomography, X-Ray Computed; Whole Body Imaging | 2016 |
Local and distributed PiB accumulation associated with development of preclinical Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Female; Follow-Up Studies; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Multivariate Analysis; Neuroimaging; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles; Tissue Distribution | 2016 |
Visualization of microbleeds with optical histology in mouse model of cerebral amyloid angiopathy.
Topics: Animals; Benzothiazoles; Carbocyanines; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Cerebrovascular Circulation; Disease Models, Animal; Fluorescent Dyes; Genetic Predisposition to Disease; Imaging, Three-Dimensional; Mice, Transgenic; Microcirculation; Microscopy, Confocal; Microvessels; Optical Imaging; Plaque, Amyloid; Staining and Labeling; Thiazoles | 2016 |
Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzothiazoles; Biomarkers; Blotting, Western; Cell Line, Tumor; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Immunohistochemistry; Liver; Male; Mice; Middle Aged; Plaque, Amyloid; Receptor, Notch1; tau Proteins; Thiazoles | 2016 |
Automated PET-only quantification of amyloid deposition with adaptive template and empirically pre-defined ROI.
Topics: Algorithms; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2016 |
The feasibility of
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Brain Mapping; Feasibility Studies; Female; Humans; Magnetic Resonance Imaging; Male; Plaque, Amyloid; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Thiazoles | 2016 |
Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice.
Topics: Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Male; Mice, Transgenic; Plaque, Amyloid; Species Specificity; Thiazoles | 2017 |
Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Cognitive Dysfunction; Dendritic Spines; Female; Humans; Male; Microfilament Proteins; Nerve Tissue Proteins; Parietal Lobe; Plaque, Amyloid; Thiazoles | 2017 |
Contrasting in vivo effects of two peptide-based amyloid-beta protein aggregation inhibitors in a transgenic mouse model of amyloid deposition.
Topics: Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Microglia; Molecular Structure; Peptides; Plaque, Amyloid; Thiazoles | 2008 |
Corticosterone and related receptor expression are associated with increased beta-amyloid plaques in isolated Tg2576 mice.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzothiazoles; Corticosterone; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Mutation; Plaque, Amyloid; Receptors, Corticotropin-Releasing Hormone; Receptors, Glucocorticoid; Stress, Psychological; Thiazoles | 2008 |
Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Basal Ganglia; Brain Mapping; Cerebral Cortex; Cognition Disorders; Female; Functional Laterality; Humans; Magnetic Resonance Imaging; Male; Nerve Fibers, Myelinated; Plaque, Amyloid; Positron-Emission Tomography; Staining and Labeling; Thiazoles | 2008 |
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzothiazoles; Cerebral Amyloid Angiopathy; Dimerization; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Plaque, Amyloid; Protein Conformation; Thiazoles | 2008 |
Molecular polymorphism of Abeta in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Coloring Agents; Congo Red; Diagnostic Imaging; Disease Models, Animal; Humans; Ligands; Molecular Probes; Pathology, Molecular; Plaque, Amyloid; Predictive Value of Tests; Protein Isoforms; Thiazoles | 2010 |
Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biopsy; Brain; Brain Mapping; Cross-Sectional Studies; Diagnosis, Differential; Disease Progression; Early Diagnosis; Female; Frontal Lobe; Humans; Hydrocephalus, Normal Pressure; Image Processing, Computer-Assisted; Intracranial Hypertension; Male; Neurofibrillary Tangles; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; tau Proteins; Thiazoles | 2008 |
Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Male; Microscopy, Confocal; Middle Aged; Neurofibrillary Tangles; Neurons; Organic Chemicals; Plaque, Amyloid; Postmortem Changes; Silver Staining; tau Proteins; Thiazoles | 2008 |
Biopsy support for the validity of Pittsburgh compound B positron emission tomography with a twist.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biopsy; Brain; Cognition Disorders; Diagnosis, Differential; Disease Progression; Early Diagnosis; False Negative Reactions; Humans; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Reproducibility of Results; Thiazoles | 2008 |
Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Autopsy; Benzothiazoles; Blotting, Western; Cohort Studies; Cytoskeleton; Humans; Immunohistochemistry; Middle Aged; Neurofibrillary Tangles; Phosphorylation; Plaque, Amyloid; Presenilin-1; Severity of Illness Index; tau Proteins; Thiazoles | 2009 |
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Ascorbic Acid; Benzothiazoles; Blotting, Western; Brain; Cerebral Ventricles; Cysteine; Dietary Supplements; Female; Glutathione; Hippocampus; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Resveratrol; Sirtuin 1; Sirtuins; Stilbenes; tau Proteins; Thiazoles; Transcription Factors; Tumor Suppressor Protein p53 | 2009 |
Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B.
Topics: Adult; Amyloid beta-Peptides; Aniline Compounds; Brain; Brain Mapping; Cerebral Amyloid Angiopathy; Cerebral Arteries; Humans; Male; Occipital Lobe; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles | 2008 |
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antineoplastic Agents; Brain; Carbon Radioisotopes; Cognition Disorders; Disease Progression; Encephalitis; Female; Gliosis; Humans; Isoquinolines; Male; Microglia; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles | 2009 |
AZD2184: a radioligand for sensitive detection of beta-amyloid deposits.
Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Autoradiography; Benzothiazoles; Brain; Carbon Radioisotopes; Competitive Bidding; Humans; Male; Mice; Mice, Transgenic; Mutation; Plaque, Amyloid; Positron-Emission Tomography; Presenilin-1; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Thiazoles; Tritium | 2009 |
Synthesis and evaluation of 18F-labeled 2-phenylbenzothiazoles as positron emission tomography imaging agents for amyloid plaques in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Blood-Brain Barrier; Brain; Fluorine Radioisotopes; Humans; Male; Mice; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Wistar; Structure-Activity Relationship; Thiazoles; Tissue Distribution | 2009 |
CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Electrophoresis, Capillary; Humans; Isoquinolines; Microscopy, Electron, Transmission; Mitoxantrone; Neuroprotective Agents; Particle Size; Peptide Fragments; Plaque, Amyloid; Protein Multimerization; Spectrometry, Fluorescence; Suramin; Thiazoles | 2009 |
Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Apolipoproteins E; Benzothiazoles; Brain; Carbon Radioisotopes; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Humans; Male; Middle Aged; Plaque, Amyloid; Polymorphism, Genetic; Positron-Emission Tomography; Risk Factors; Thiazoles | 2009 |
In vivo mapping of amyloid toxicity in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Benzothiazoles; Brain; Female; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2009 |
Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzoxazoles; Brain; Carbon Radioisotopes; Cognition Disorders; Early Diagnosis; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Neocortex; Nerve Fibers, Unmyelinated; Neuropsychological Tests; Parahippocampal Gyrus; Plaque, Amyloid; Positron-Emission Tomography; Severity of Illness Index; Signal Processing, Computer-Assisted; Thiazoles | 2009 |
Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study.
Topics: Aged; Alzheimer Disease; Amnesia; Aniline Compounds; Carbon Radioisotopes; Cognition Disorders; Disease Progression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles; Time Factors | 2009 |
Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotin; Disease Models, Animal; Humans; Immunohistochemistry; Islet Amyloid Polypeptide; Ligands; Male; Mice; Mice, Transgenic; Microscopy, Atomic Force; Molecular Weight; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2010 |
Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Cell Count; Diabetes Mellitus; Female; Fluorescent Antibody Technique; Glycation End Products, Advanced; Humans; Immunohistochemistry; Male; Microglia; Middle Aged; Peptide Fragments; Plant Lectins; Plaque, Amyloid; Receptor for Advanced Glycation End Products; Receptors, Immunologic; tau Proteins; Thiazoles | 2010 |
A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain; Cell Line; Cells, Cultured; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Mice; Mice, Transgenic; Mutation; Neprilysin; Neurons; Plaque, Amyloid; PPAR delta; Presenilin-1; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Transfection | 2009 |
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line, Tumor; Cytoplasmic Vesicles; Fluorescence; Humans; Immunoblotting; Mice; Microscopy, Confocal; Neurons; Plaque, Amyloid; Thiazoles | 2009 |
Posterior cortical atrophy with [11C] Pittsburgh compound B accumulation in the primary visual cortex.
Topics: Aniline Compounds; Atrophy; Brain Mapping; Disease Progression; Energy Metabolism; Female; Fluorodeoxyglucose F18; Hemianopsia; Humans; Magnetic Resonance Imaging; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles; Vision Disorders; Visual Cortex | 2010 |
Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET.
Topics: Aged; Alzheimer Disease; Amyloid; Benzoxazoles; Brain; Brain Mapping; Carbon Radioisotopes; Cognition Disorders; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Plaque, Amyloid; Positron-Emission Tomography; ROC Curve; Sensitivity and Specificity; Thiazoles | 2010 |
Beta-amyloid burden in the temporal neocortex is related to hippocampal atrophy in elderly subjects without dementia.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Algorithms; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Biomarkers; Brain Mapping; Carbon Radioisotopes; Cohort Studies; Disease Progression; Female; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neocortex; Nerve Degeneration; Plaque, Amyloid; Positron-Emission Tomography; Severity of Illness Index; Temporal Lobe; Thiazoles | 2010 |
2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl) amino]-2-naphthyl} ethylidene)malononitrile (FDDNP) positron emission tomography patterns in nondemented populations.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Cognition Disorders; Female; Humans; Male; Middle Aged; Neurofibrillary Tangles; Nitriles; Plaque, Amyloid; Positron-Emission Tomography; Temporal Lobe; Thiazoles | 2010 |
Lack of association between 11C-PiB and longitudinal brain atrophy in non-demented older individuals.
Topics: Aged; Aged, 80 and over; Aniline Compounds; Atrophy; Benzothiazoles; Brain; Carbon Radioisotopes; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Prospective Studies; Thiazoles | 2011 |
APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E2; Apolipoprotein E4; Apolipoproteins E; Brain; Female; Follow-Up Studies; Genotype; Humans; Longitudinal Studies; Male; Middle Aged; Peptide Fragments; Phosphorylation; Plaque, Amyloid; tau Proteins; Thiazoles | 2010 |
Burden of neurodegenerative diseases in a cohort of medical examiner subjects.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Atrophy; Benzothiazoles; Brain; Brain Edema; Cohort Studies; Coroners and Medical Examiners; Female; Forensic Pathology; Frontotemporal Lobar Degeneration; Humans; Hygiene; Ill-Housed Persons; Immunohistochemistry; Male; Malnutrition; Middle Aged; Neurofibrillary Tangles; Neuropil Threads; Plaque, Amyloid; Staining and Labeling; Tauopathies; Thiazoles; Young Adult | 2010 |
Relationship between atrophy and beta-amyloid deposition in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Benzothiazoles; Biomarkers; Brain; Cognition Disorders; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Male; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Prognosis; Severity of Illness Index; Thiazoles | 2010 |
Cognition, reserve, and amyloid deposition in normal aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Cognition; Cognition Disorders; Disability Evaluation; Disease Progression; Female; Humans; Longitudinal Studies; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Reference Values; Severity of Illness Index; Thiazoles | 2010 |
Voxel-based analysis of Alzheimer's disease PET imaging using a triplet of radiotracers: PIB, FDDNP, and FDG.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Brain; Brain Mapping; Case-Control Studies; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Neurofibrillary Tangles; Nitriles; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Signal Processing, Computer-Assisted; Thiazoles | 2010 |
Plaque deposition dependent decrease in 5-HT2A serotonin receptor in AbetaPPswe/PS1dE9 amyloid overexpressing mice.
Topics: Aging; Amphetamines; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Autoradiography; Citalopram; Data Interpretation, Statistical; Fluorobenzenes; Genes, fos; Head Movements; Humans; In Situ Hybridization; Indicators and Reagents; Male; Mice; Mice, Transgenic; Piperidines; Plaque, Amyloid; Receptor, Serotonin, 5-HT2A; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Serotonin Receptor Agonists; Thiazoles | 2010 |
Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Australia; Biomarkers; Cohort Studies; Echo-Planar Imaging; Female; Genetic Carrier Screening; Hippocampus; Humans; Longitudinal Studies; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Prospective Studies; Risk Reduction Behavior; Thiazoles | 2010 |
Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Apolipoprotein E4; Brain; Disease Progression; Female; Fluorodeoxyglucose F18; Genotype; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2010 |
In vivo amyloid imaging in cortical superficial siderosis.
Topics: Aged; Aniline Compounds; Brain; Female; Humans; Magnetic Resonance Imaging; Male; Plaque, Amyloid; Radionuclide Imaging; Siderosis; Thiazoles | 2011 |
Voxel-based analysis of amyloid positron emission tomography probe [C]BF-227 uptake in mild cognitive impairment and alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzoxazoles; Carbon Radioisotopes; Cerebral Cortex; Data Interpretation, Statistical; Disease Progression; Educational Status; Evidence-Based Medicine; Female; Humans; Male; Plaque, Amyloid; Positron-Emission Tomography; Sex Factors; Thiazoles; Wechsler Scales | 2010 |
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA1 Region, Hippocampal; Creatine; Disease Models, Animal; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Thiazoles | 2010 |
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Benzothiazoles; Biophysics; Fluorescent Dyes; Humans; Kinetics; Mice; Microelectrodes; Microscopy, Electron, Transmission; Neurons; Patch-Clamp Techniques; Peptide Fragments; Plaque, Amyloid; Protein Binding; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2010 |
Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Brain Chemistry; Cerebral Cortex; Chlamydia Infections; Chlamydophila pneumoniae; Coloring Agents; Female; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Plaque, Amyloid; Reproducibility of Results; Thiazoles; Tissue Banks | 2010 |
Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Disease Progression; Female; Humans; Middle Aged; Neurofibrillary Tangles; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2011 |
APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42.
Topics: Alleles; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Brain Mapping; Female; Genotype; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Peptide Fragments; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2010 |
Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer's.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Peptide Fragments; Plaque, Amyloid; Proteins; Regression Analysis; Thiazoles | 2011 |
Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Cognition; Cognition Disorders; Disease Progression; Female; Follow-Up Studies; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Plaque, Amyloid; Polymorphism, Genetic; Positron-Emission Tomography; Severity of Illness Index; Thiazoles | 2011 |
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
Topics: Acetamides; Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Autoradiography; Brain; Humans; Immunohistochemistry; Isotope Labeling; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Neuritis; Neuroglia; Pick Disease of the Brain; Plaque, Amyloid; Positron-Emission Tomography; Purines; Radiopharmaceuticals; Receptors, GABA; Supranuclear Palsy, Progressive; tau Proteins; Thiazoles | 2011 |
Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB).
Topics: Alzheimer Disease; Aniline Compounds; Automation, Laboratory; Benzothiazoles; Carbon Radioisotopes; Humans; Isotope Labeling; Plaque, Amyloid; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2011 |
Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Blood-Brain Barrier; Contrast Media; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Kinetics; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Molecular Targeted Therapy; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Library; Peptides, Cyclic; Plaque, Amyloid; Protein Binding; Sequence Analysis, DNA; Thiazoles | 2011 |
Association between in vivo fluorine 18-labeled flutemetamol amyloid positron emission tomography imaging and in vivo cerebral cortical histopathology.
Topics: Aged; Aged, 80 and over; Aniline Compounds; Benzothiazoles; Cerebral Cortex; Cross-Sectional Studies; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2011 |
Amyloid imaging: liberal or conservative? Let the data decide.
Topics: Alzheimer Disease; Aniline Compounds; Benzothiazoles; Cerebral Cortex; Cognitive Dysfunction; Dementia; Ethylene Glycols; Female; Fluorine Radioisotopes; Humans; Male; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2011 |
Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; Astrocytes; Benzothiazoles; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Microglia; Neuroglia; Plaque, Amyloid; Protein Processing, Post-Translational; Receptors, LDL; Thiazoles | 2011 |
Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arterioles; Benzothiazoles; Disease Models, Animal; Ferric Compounds; Humans; Immunoglobulin G; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Nanoparticles; Peptide Fragments; Plaque, Amyloid; Platelet Endothelial Cell Adhesion Molecule-1; Thiazoles | 2011 |
Protein L-isoaspartyl O-methyltransferase inhibits amyloid beta fibrillogenesis in vitro.
Topics: Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Circular Dichroism; Escherichia coli; Fluorescent Dyes; Humans; Microscopy, Electron, Transmission; Molecular Weight; Plaque, Amyloid; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Structure, Secondary; Thiazoles | 2011 |
Clinical course of patients with familial early-onset Alzheimer's disease potentially lacking senile plaques bearing the E693Δ mutation in amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Apolipoproteins E; Atrophy; Benzothiazoles; Brain; Cerebellar Ataxia; Cognition; Disease Progression; Female; Fluorodeoxyglucose F18; Gait Disorders, Neurologic; Humans; Magnetic Resonance Imaging; Memory Disorders; Middle Aged; Mutation; Neuropsychological Tests; Pedigree; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2011 |
Effects of age and amyloid deposition on Aβ dynamics in the human central nervous system.
Topics: Adult; Aged; Aged, 80 and over; Aging; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Case-Control Studies; Central Nervous System; Circadian Rhythm; Electroencephalography; Enzyme-Linked Immunosorbent Assay; Female; Humans; Linear Models; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Sleep; Thiazoles; Video Recording; Wakefulness | 2012 |
Amyloid-β oligomers stimulate microglia through a tyrosine kinase dependent mechanism.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cells, Cultured; Dasatinib; Female; Humans; Male; Mice; Mice, Inbred C57BL; Microglia; Phosphotyrosine; Plaque, Amyloid; Polymers; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Thiazoles; Tumor Necrosis Factor-alpha | 2012 |
Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Cognition; Early Diagnosis; Humans; Longitudinal Studies; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2011 |
Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Humans; Male; Neurofibrillary Tangles; Plaque, Amyloid; Radionuclide Imaging; Thiazoles | 2012 |
Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Aniline Compounds; Animals; Benzothiazoles; Enzyme-Linked Immunosorbent Assay; Mice; Mice, Mutant Strains; Microscopy, Fluorescence; Plaque, Amyloid; Positron-Emission Tomography; Radioligand Assay; Thiazoles; Translational Research, Biomedical | 2012 |
Cross-seeding effects of amyloid β-protein and α-synuclein.
Topics: alpha-Synuclein; Amyloid beta-Peptides; Animals; Benzothiazoles; Chromatography, Gel; Humans; Microscopy, Electron, Scanning; Peptide Fragments; Plaque, Amyloid; Protein Binding; Thiazoles | 2012 |
Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Brain; Case-Control Studies; Ethylene Glycols; Female; Humans; Male; Neuroimaging; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2012 |
Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Benzothiazoles; Female; Humans; Male; Neurofibrillary Tangles; Neuroimaging; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2012 |
Interaction between amyloid-β pathology and cortical functional columnar organization.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Electron Transport Complex IV; Humans; Mice; Mice, Transgenic; Models, Neurological; Mutation; Neural Pathways; Plaque, Amyloid; Presenilin-1; Somatosensory Cortex; Thiazoles | 2012 |
Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease.
Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Biomarkers; Brain; Brain Chemistry; Female; Humans; Male; Neurofibrillary Tangles; Neuropsychological Tests; Plaque, Amyloid; Predictive Value of Tests; Radionuclide Imaging; Radiopharmaceuticals; Sodium Dodecyl Sulfate; Solubility; Surface-Active Agents; Thiazoles | 2012 |
A 18F-labeled BF-227 derivative as a potential radioligand for imaging dense amyloid plaques by positron emission tomography.
Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Animals; Autoradiography; Benzoxazoles; Brain; Demography; Female; Fluorine Radioisotopes; Humans; Ligands; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles; Time Factors; Tissue Distribution | 2013 |
Positron emission tomography with [18F]flutemetamol and [11C]PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients.
Topics: Aged; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Biopsy; Cerebral Cortex; Female; Functional Neuroimaging; Humans; Hydrocephalus, Normal Pressure; Male; Plaque, Amyloid; Radionuclide Imaging; Sensitivity and Specificity; Thiazoles | 2013 |
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Clusterin; Disease Models, Animal; Glycoproteins; Mice; Mice, Knockout; Molecular Chaperones; Neurites; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2002 |
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
Topics: Administration, Topical; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Immunotherapy; Mice; Mice, Transgenic; Microscopy, Fluorescence; Mutation; Phagocytosis; Plaque, Amyloid; Thiazoles | 2002 |
Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autoantibodies; Benzothiazoles; Brain; Cerebellum; Disease Models, Animal; Locus Coeruleus; Mice; Mice, Transgenic; Neostriatum; Nerve Growth Factor; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; Signal Transduction; Silver Staining; Thiazoles | 2002 |
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Disease Models, Animal; Female; Humans; Male; Membrane Proteins; Mice; Mice, Transgenic; Neurotoxins; Plaque, Amyloid; Presenilin-1; Thiazoles | 2002 |
IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autopsy; Autoradiography; Benzothiazoles; Fluorescence; Humans; Mice; Mice, Transgenic; Molecular Probes; Plaque, Amyloid; Pyridines; Thiazoles | 2002 |
Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Binding, Competitive; Blood-Brain Barrier; Brain; Contrast Media; Disease Models, Animal; Gadolinium; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Transgenic; Molecular Probe Techniques; Neurons; Peptide Fragments; Plaque, Amyloid; Predictive Value of Tests; Presenilin-1; Putrescine; Reproducibility of Results; Thiazoles | 2002 |
In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Axons; Benzothiazoles; Cerebral Cortex; Dendrites; Dextrans; Disease Models, Animal; Fluorescent Dyes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Neurites; Neuropil; Plaque, Amyloid; Thiazoles | 2003 |
Direct observation of amyloid fibril growth monitored by thioflavin T fluorescence.
Topics: Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Microscopy, Fluorescence; Plaque, Amyloid; Thiazoles | 2003 |
In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antioxidants; Benzothiazoles; Cerebral Cortex; Cyclic N-Oxides; Disease Models, Animal; Fluorescent Dyes; Free Radical Scavengers; Free Radicals; Infrared Rays; Lasers; Mice; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Nitrogen Oxides; Oxidation-Reduction; Oxidative Stress; Plaque, Amyloid; Reactive Oxygen Species; Thiazoles | 2003 |
Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Artifacts; Binding, Competitive; Blood-Brain Barrier; Brain; Humans; Immunohistochemistry; Iodine Radioisotopes; Mice; Mice, Transgenic; Nerve Fibers, Myelinated; Peptide Fragments; Plaque, Amyloid; Radionuclide Imaging; Reproducibility of Results; Styrenes; Thiazoles | 2003 |
Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Antibody Technique; Humans; Inclusion Bodies; Microtubule-Associated Proteins; Neocortex; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; tau Proteins; Thiazoles | 2003 |
Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Benzothiazoles; Drug Administration Routes; Frontal Lobe; Hippocampus; Histocompatibility Antigens Class II; Immunization, Passive; Immunohistochemistry; Leukocyte Common Antigens; Membrane Proteins; Mice; Mice, Transgenic; Microglia; Plaque, Amyloid; Presenilin-1; Thiazoles; Time Factors | 2003 |
Characterization of radioiodinated ligand binding to amyloid beta plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Brain; Humans; Iodine Radioisotopes; Ligands; Male; Mice; Mice, Inbred ICR; Peptide Fragments; Plaque, Amyloid; Pyrazoles; Pyridines; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2003 |
Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives.
Topics: Alzheimer Disease; Animals; Binding Sites; Binding, Competitive; Brain; Female; Iodine Radioisotopes; Membrane Lipids; Mice; Molecular Conformation; Molecular Structure; Plaque, Amyloid; Radionuclide Imaging; Thiazoles | 2003 |
Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Biological Transport, Active; Blood-Brain Barrier; Brain; Fluorescent Dyes; Humans; Ligands; Mice; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Plaque, Amyloid; Protein Binding; Thiazoles; Tomography, Emission-Computed | 2003 |
In vivo labeling of amyloid with BF-108.
Topics: Acridines; Affinity Labels; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Brain; Female; Fluorescent Dyes; Humans; In Vitro Techniques; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Neurofibrillary Tangles; Plaque, Amyloid; Rats; Rats, Wistar; Thiazoles | 2004 |
Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antibodies; Benzothiazoles; Fluorescence; Microscopy, Atomic Force; Neurofibrillary Tangles; Peptide Fragments; Plaque, Amyloid; Protein Structure, Quaternary; Software; Thiazoles | 2004 |
Neuronal localization of C1q in preclinical Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biomarkers; Brain; Cerebral Cortex; Complement C1q; Disease Progression; Down Syndrome; Encephalitis; Female; Genetic Predisposition to Disease; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Humans; Immunohistochemistry; Middle Aged; Neurons; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2004 |
Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Humans; Immunoglobulin Variable Region; Microscopy, Atomic Force; Neuroblastoma; Neurons; Peptide Library; Plaque, Amyloid; Surface Plasmon Resonance; Thiazoles; Tumor Cells, Cultured | 2004 |
Inflammation occurs early during the Abeta deposition process in TgCRND8 mice.
Topics: Age Factors; Alzheimer Disease; Amygdala; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; CD11b Antigen; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neocortex; Plaque, Amyloid; Thiazoles | 2004 |
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Benzothiazoles; Down Syndrome; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Male; Membrane Proteins; Mice; Mice, Transgenic; Middle Aged; Neocortex; Neurons; Non-Fibrillar Collagens; Peptide Fragments; Plaque, Amyloid; Thiazoles; Tissue Distribution | 2004 |
Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Binding, Competitive; Brain; Carbon Radioisotopes; Cerebellum; Disease Models, Animal; Female; Frontal Lobe; Humans; Iodine Radioisotopes; Metabolic Clearance Rate; Mice; Mice, Transgenic; Molecular Structure; Plaque, Amyloid; Positron-Emission Tomography; Radioligand Assay; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2004 |
Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Heterozygote; Humans; Immunization, Passive; Immunotherapy; Metabolic Clearance Rate; Mice; Mice, Transgenic; Neurites; Neurofibrillary Tangles; Plaque, Amyloid; Thiazoles | 2004 |
Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Survival; Cells, Cultured; Hippocampus; Inhibitory Concentration 50; Neurons; Neuroprotective Agents; Plaque, Amyloid; Protein Structure, Quaternary; Rats; Solubility; Thiazoles | 2004 |
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Benzothiazoles; Biphenyl Compounds; Blood-Brain Barrier; Brain; Cell Line, Tumor; Congo Red; Curcumin; Diamines; Humans; Ibuprofen; Mice; Mice, Transgenic; Naproxen; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Denaturation; Protein Structure, Quaternary; Pyridazines; Solubility; Thiazoles | 2005 |
Inducible neuronal expression of transgenic TGF-beta1 in vivo: dissection of short-term and long-term effects.
Topics: Animals; Anti-Bacterial Agents; Apolipoproteins E; Benzothiazoles; Brain; Doxycycline; Gene Expression Regulation; Gene Silencing; Mice; Mice, Transgenic; Molecular Biology; Nerve Degeneration; Neurodegenerative Diseases; Neurons; Neuroprotective Agents; Neurotoxins; Nitro Compounds; Plaque, Amyloid; Propionates; Thiazoles; Transfection; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transgenes | 2005 |
Abeta42 is essential for parenchymal and vascular amyloid deposition in mice.
Topics: Age Factors; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Blood Vessels; Blotting, Northern; Blotting, Western; Brain; Cerebral Amyloid Angiopathy; Enzyme-Linked Immunosorbent Assay; Female; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Immunoprecipitation; In Situ Hybridization; Male; Mass Spectrometry; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Mutation; Peptide Fragments; Pia Mater; Plaque, Amyloid; Thiazoles | 2005 |
Amyloid plaque imaging agent [C-11]-6-OH-BTA-1: biodistribution and radiation dosimetry in baboon.
Topics: Animals; Brain; Female; Male; Metabolic Clearance Rate; Organ Specificity; Papio; Plaque, Amyloid; Positron-Emission Tomography; Radiation Dosage; Radiometry; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; Tissue Distribution; Whole-Body Counting | 2005 |
Cerebrospinal fluid of Alzheimer patients promotes beta-amyloid fibril formation in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Brain Chemistry; Cerebrospinal Fluid; Humans; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Middle Aged; Peptide Fragments; Plaque, Amyloid; Polymers; Thiazoles | 2005 |
In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice.
Topics: Age Factors; Alzheimer Disease; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Plaque, Amyloid; Staining and Labeling; Thiazoles | 2005 |
Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblasts.
Topics: Adult; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Apoptosis; Case-Control Studies; Caspase 3; Cells, Cultured; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Extracellular Fluid; Family Health; Fibroblasts; Humans; Middle Aged; Oxidative Stress; Plaque, Amyloid; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors | 2007 |
Lipophilic analogs of thioflavin S as novel amyloid-imaging agents.
Topics: Affinity Labels; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding, Competitive; Carbon Radioisotopes; Diagnostic Imaging; Drug Evaluation, Preclinical; Fluorescent Dyes; Humans; Iodine Radioisotopes; Mice; Molecular Structure; Neurofibrillary Tangles; Plaque, Amyloid; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2006 |
Development of amyloid imaging PET probes for an early diagnosis of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzoxazoles; Early Diagnosis; Humans; Mice; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2006 |
Linear quantitation of Abeta aggregation using Thioflavin T: reduction in fibril formation by colostrinin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biological Assay; Biomarkers; Dose-Response Relationship, Drug; Down-Regulation; Fluorescence; Fluorescent Dyes; Humans; Intercellular Signaling Peptides and Proteins; Linear Models; Microscopy, Fluorescence; Molecular Weight; Neurochemistry; Neuroprotective Agents; Peptide Fragments; Peptides; Plaque, Amyloid; Solubility; Thiazoles | 2007 |
Viral-induced inflammation is accompanied by beta-amyloid plaque reduction in brains of amyloid precursor protein transgenic Tg2576 mice.
Topics: Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Benzothiazoles; Borna disease virus; Brain; Cytokines; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Gene Expression; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroglia; Nucleoproteins; Plaque, Amyloid; T-Lymphocytes; Thiazoles; Time Factors; Viral Proteins | 2006 |
Protection by EGb 761 against beta-amyloid-induced neurotoxicity: involvement of NF-kappaB, SIRT1, and MAPKs pathways and inhibition of amyloid fibril formation.
Topics: Amyloid beta-Peptides; Benzothiazoles; Cell Survival; Flavonoids; Ginkgo biloba; Ginkgolides; Humans; Lactones; MAP Kinase Kinase 4; Microscopy, Electron; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Models, Biological; Neuroprotective Agents; Neurotoxicity Syndromes; NF-kappa B; Plant Extracts; Plaque, Amyloid; Sirtuin 1; Sirtuins; Thiazoles; Tumor Cells, Cultured | 2006 |
Preferential association of serum amyloid P component with fibrillar deposits in familial British and Danish dementias: similarities with Alzheimer's disease.
Topics: Adaptor Proteins, Signal Transducing; Aged; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Biomarkers; Brain; Cerebral Amyloid Angiopathy, Familial; Dementia; Denmark; England; Humans; Immunohistochemistry; Membrane Glycoproteins; Membrane Proteins; Neurofibrils; Peptide Fragments; Plaque, Amyloid; Protein Subunits; Serum Amyloid P-Component; Thiazoles | 2007 |
PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Brain Mapping; Cognition Disorders; Female; Humans; Male; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles | 2007 |
PET imaging of amyloid deposition in patients with mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Cerebral Cortex; Cognition Disorders; Disease Progression; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Prognosis; Thiazoles | 2008 |
Surface structure of amyloid-beta fibrils contributes to cytotoxicity.
Topics: Acetylation; Amyloid beta-Peptides; Animals; Benzothiazoles; Carrier Proteins; Cattle; Cell Survival; Cells, Cultured; Fluorescence; Humans; Kidney; Maltose-Binding Proteins; Microscopy, Electron, Transmission; Peptide Fragments; Plaque, Amyloid; Thiazoles; Tryptophan | 2007 |
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Immunotherapy; Mice; Mice, Transgenic; Molecular Sequence Data; Plaque, Amyloid; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2007 |
Differentiating Alzheimer disease-associated aggregates with small molecules.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Mass Spectrometry; Neurofibrillary Tangles; Peptide Library; Plaque, Amyloid; tau Proteins; Thiazines; Thiazoles | 2007 |
Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Apolipoproteins E; Benzothiazoles; Brain; Brain Chemistry; Dementia; Female; Fluorodeoxyglucose F18; Functional Laterality; Genotype; Glucose; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2008 |
Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Carbon Radioisotopes; Cerebral Cortex; Cerebrovascular Circulation; Disease Susceptibility; Educational Status; Energy Metabolism; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Recovery of Function; Thiazoles | 2008 |
Robust estimation of the arterial input function for Logan plots using an intersectional searching algorithm and clustering in positron emission tomography for neuroreceptor imaging.
Topics: Algorithms; Aniline Compounds; Benzothiazoles; Cerebral Arteries; Cluster Analysis; Computer Simulation; Humans; Image Processing, Computer-Assisted; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Receptor, Adenosine A2A; Reproducibility of Results; Sensory Receptor Cells; Thiazoles; Xanthines | 2008 |
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Brain; Carbon Radioisotopes; Enzyme-Linked Immunosorbent Assay; Female; Humans; Image Interpretation, Computer-Assisted; Immunohistochemistry; Magnetic Resonance Imaging; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Positron-Emission Tomography; Reproducibility of Results; tau Proteins; Thiazoles | 2008 |
Butyrylcholinesterase in the life cycle of amyloid plaques.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Butyrylcholinesterase; Case-Control Studies; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Plaque, Amyloid; Temporal Lobe; Thiazoles | 1997 |
Rat microglia exhibit increased density on Alzheimer's plaques in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzothiazoles; Brain; Carbocyanines; Cell Count; Cells, Cultured; Fluorescent Dyes; Humans; Lipoproteins, LDL; Microglia; Middle Aged; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Reference Values; Thiazoles | 1998 |
Sympathetic neurite outgrowth is greater on plaque-poor vs. plaque-rich regions of Alzheimer's disease cryostat sections.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Animals; Benzothiazoles; Case-Control Studies; Chick Embryo; Cryopreservation; Fluorescent Dyes; Humans; Neurites; Plaque, Amyloid; Sympathetic Nervous System; Thiazoles | 1998 |
Laminin blocks the assembly of wild-type A beta and the Dutch variant peptide into Alzheimer's fibrils.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Amyloidosis; Benzothiazoles; Fluorescence; Kinetics; Laminin; Nephelometry and Turbidimetry; Peptide Fragments; Plaque, Amyloid; Protein Binding; Thiazoles | 1998 |
Relationship between plaques, tangles, and loss of cortical cholinergic fibers in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cerebral Cortex; Choline O-Acetyltransferase; Fluorescent Dyes; Humans; Nerve Fibers; Neurofibrillary Tangles; Organ Specificity; Plaque, Amyloid; Reference Values; Regression Analysis; Thiazoles | 1998 |
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Brain; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Peptide Fragments; Plaque, Amyloid; Reference Values; Solubility; Thiazoles | 1999 |
The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Crystallins; Dose-Response Relationship, Drug; Hippocampus; Molecular Chaperones; Neurons; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Structure, Secondary; Rats; Thiazoles | 1999 |
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Benzothiazoles; Disease Models, Animal; Genetic Predisposition to Disease; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Nerve Degeneration; Neurites; Plaque, Amyloid; Protein Isoforms; Thiazoles; Time Factors | 2000 |
A possible model of senile plaques using synthetic amyloid beta-protein and rat glial culture.
Topics: Amyloid beta-Peptides; Animals; Astrocytes; Benzothiazoles; Cells, Cultured; Coloring Agents; Congo Red; Fluorescent Antibody Technique; Glial Fibrillary Acidic Protein; Histocompatibility Antigens Class II; Image Processing, Computer-Assisted; Interleukin-1; Microglia; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Staining and Labeling; Thiazoles | 2000 |
Orbitofrontal cortex pathology in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Dyes; Frontal Lobe; Humans; Middle Aged; Neurofibrillary Tangles; Organ Size; Plaque, Amyloid; Thiazoles | 2000 |
High density lipoprotein inhibits assembly of amyloid beta-peptides into fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Fluorometry; Humans; Lipoproteins, HDL; Nerve Tissue Proteins; Particle Size; Peptide Fragments; Plaque, Amyloid; Protein Binding; Solubility; Thiazoles | 2000 |
X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology.
Topics: Aged; Aged, 80 and over; Alkenes; Alzheimer Disease; Amyloid; Amyloidosis; Benzoates; Benzothiazoles; Coloring Agents; Congo Red; Female; Fluorescent Dyes; Histocytochemistry; Humans; Male; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Protein Structure, Secondary; Silver; Thiazoles | 2000 |
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Disease Models, Animal; Disease Progression; Feedback; Fluorescent Dyes; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy; Plaque, Amyloid; Thiazoles | 2001 |
Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Complement C1q; Down Syndrome; Encephalitis; Female; Humans; Immunohistochemistry; Male; Microglia; Middle Aged; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; Thiazoles | 2001 |
Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cell Count; Data Interpretation, Statistical; Disease Models, Animal; Hippocampus; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Plaque, Amyloid; Reproducibility of Results; Statistical Distributions; Thiazoles | 2001 |
The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cerebral Cortex; Fluorescent Dyes; Humans; Immunohistochemistry; Microscopy, Confocal; Nerve Degeneration; Neurites; Neurofilament Proteins; Phenotype; Plaque, Amyloid; tau Proteins; Thiazoles | 2001 |
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption.
Topics: Action Potentials; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Dendrites; In Vitro Techniques; Mice; Mice, Transgenic; Microscopy, Confocal; Models, Neurological; Neurites; Plaque, Amyloid; Reaction Time; Thiazoles | 2001 |
Relationship of calbindin D28K-immunoreactive cells and neuropathological changes in the hippocampal formation of Alzheimer's disease.
Topics: Age of Onset; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Benzothiazoles; Calbindin 1; Calbindins; Female; Fluorescent Dyes; Hippocampus; Humans; Immunohistochemistry; Male; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Pyramidal Cells; S100 Calcium Binding Protein G; Thiazoles | 2001 |
Vasculopathy and amyloid beta reactivity in brains of patients with acquired immune deficiency (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS Dementia Complex; AIDS-Related Opportunistic Infections; Amyloid beta-Peptides; Axons; Benzothiazoles; Brain; Brain Chemistry; Brain Neoplasms; Cerebral Arteries; Cerebral Veins; Cerebrovascular Circulation; Coloring Agents; Congo Red; Female; Humans; Leukoencephalopathy, Progressive Multifocal; Lymphoma, AIDS-Related; Lymphoma, B-Cell; Male; Meningitis, Cryptococcal; Middle Aged; Plaque, Amyloid; Thiazoles; Toxoplasmosis, Cerebral; Ubiquitin; Vasculitis | 2000 |
Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Congo Red; Disease Models, Animal; Gene Expression Regulation, Developmental; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microscopy, Electron; Mutagenesis, Insertional; Mutation; Neurites; Neurons; Peptide Fragments; Plaque, Amyloid; Presynaptic Terminals; Promoter Regions, Genetic; Thiazoles | 2001 |
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
Topics: Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Binding, Competitive; Brain; Chemical Phenomena; Chemistry, Physical; Mice; Mice, Transgenic; Microscopy; Plaque, Amyloid; Radiopharmaceuticals; Structure-Activity Relationship; Thiazoles; Tomography, Emission-Computed | 2002 |
Amyloid-beta deposits in the cerebral cortex of the aged common marmoset (Callithrix jacchus): incidence and chemical composition.
Topics: Aging; alpha 1-Antichymotrypsin; Amyloid beta-Peptides; Animals; Apolipoproteins E; Benzothiazoles; Brain Diseases; Callithrix; Cerebral Cortex; Cholinesterases; Disease Models, Animal; Female; Incidence; Male; Neurites; Peptide Fragments; Plaque, Amyloid; Survival Analysis; Thiazoles | 2002 |