Compounds > thiazoles
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thiazoles and Adjuvant Arthritis

thiazoles has been researched along with Adjuvant Arthritis in 59 studies

Research

Studies (59)

TimeframeStudies, this research(%)All Research%
pre-199010 (16.95)18.7374
1990's12 (20.34)18.2507
2000's24 (40.68)29.6817
2010's13 (22.03)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bhagyaraj, E; Gupta, P; Gupta, R; Kalra, R; Khatri, N; Mahajan, S; Nanduri, R; Saini, A1
Aghazadeh-Habashi, A; Asghar, W; Jamali, F1
Hata, T; Iwasaki, H; Kato, T; Kobayashi, H; Matsuo, A; Matsushita, M; Ohta, T1
Ding, Y; Dong, Y; Fan, C; Wu, M; Zhang, L; Zou, F1
Bertram, JE; Gutmann, A; Hurtig, M; Matyas, JR; Randev, J1
Chang, YC; Chen, CH; Chen, WF; Hsieh, CS; Hsieh, SP; Huang, SY; Jean, YH; Kuo, HC; Lee, CH; Lee, HL; Lin, SY; Tang, CC; Wang, KY; Wen, ZH; Wu, SC1
Endo, M; Fujii, Y; Fujita, K; Inoue, T; Kimura, K; Kuroda, S; Ohtake, H; Oi, T; Oka, Y; Sekiguchi, Y; Taguchi, K; Wakahara, S; Yabuuchi, T1
Diao, Y; Dong, D; Li, H; Li, S; Liu, X; Luan, G; Ren, X; Song, W; Wang, R; Xu, L; Xu, M; Xu, Y; Zhao, Z; Zhu, J; Zhu, L1
Bi, RY; Ding, Y; Gan, YH1
Castillero, E; Granado, M; López-Calderón, A; Martín, AI; Villanúa, MA1
Astner, L; Erlandsson-Harris, H; Grabowska, U; Hewitt, E; Klareskog, L; Lindstrom, E; Svelander, L1
Ah, YC; Bae, JH; Choi, JK; Choi, YK; Ki, HM1
Cole, GA; Keuler, NS; Klauer, JM; Krugner-Higby, L; Medlin, SE; Paul-Murphy, J; Sladky, KK1
Hashmi, JA; Henry, JL; Holdsworth, DW; Yashpal, K1
Cho, IJ; Choi, IY; Han, SB; Kang, JS; Kim, HM; Lee, CW; Lee, H; Lee, K; Lee, KH; Park, KH; Park, SK; Yoon, YD1
Bolli, MH; Clozel, M; Froidevaux, S; Hess, P; Kohl, C; Nayler, O; Piali, L; Schlosser, E; Steiner, B1
Bullington, JL; Jackson, PF1
Diez-Ortego, I; Egido, J; Herrero-Beaumont, G; Largo, R; López-Armada, MJ; Palacios, I; Sánchez-Pernaute, O1
Ogino, K; Osugi, T; Saito, K; Satoh, H1
NEWBOULD, BB1
Blum, E; Buhl, T; Di Padova, FE; Feifel, R; Gram, H; Hiestand, P; Manning, U; Revesz, L; Rucklin, G1
Dai, M; Liu, LH; Shen, YX; Wei, W; Zheng, YQ1
Barrish, JC; Behnia, K; Chen, BC; Chen, P; Das, J; De Fex, HF; Doweyko, AM; Leith, L; McIntyre, KW; Norris, D; Pang, S; Pitt, S; Schieven, GL; Shen, DR; Shuster, DJ; Spergel, SH; Wityak, J; Zhang, R; Zhao, R1
Cester, CC; Toutain, PL1
Arikawa, Y; Igaki, K; Kawamoto, T; Kimura, H; Miwatashi, S; Naruo, K; Ohkawa, S; Watanabe, Y1
Ardissone, V; Arkinstall, S; Cambet, Y; Camps, M; Chabert, C; Church, D; Cirillo, R; Gaillard, P; Gotteland, JP; Gretener, D; Halazy, S; Jeanclaude-Etter, I; Nichols, A; Szyndralewiez, C; Vitte, PA1
Arikawa, Y; Asahi, S; Kimura, H; Kotani, E; Miwatashi, S; Miyamoto, M; Naruo, K; Ohkawa, S; Tanaka, T1
Barrish, JC; Behnia, K; Chen, P; Cook, LS; Das, J; de Fex, HF; Doweyko, AM; Fang, Q; Gillooly, KM; Lin, J; McIntyre, KW; Moquin, RV; Norris, D; Padmanabha, R; Pang, S; Pitt, S; Schieven, GL; Shen, DR; Shen, Z; Shuster, DJ; Wityak, J1
Granado, M; López-Calderón, A; Martín, AI; Villanúa, MA1
Itahana, H; Kiso, T; Kohara, A; Nagakura, Y; Okada, M; Shitaka, Y; Tamura, S; Toya, T; Watabiki, T1
Hirano, T; Kageyama, Y; Kohno, E; Koide, Y; Nagano, A; Terakawa, S; Torikai, E1
Kubo, K; Murooka, H; Ohno, H; Ohzeki, Y; Serizawa, I; Takanashi, H; Tokieda, T; Uemura, Y1
Harirforoosh, S; Jamali, F1
Carlson, RP; Chang, J; Lewis, AJ1
Bender, PE; DiMartino, MJ; Griswold, DE; Lantos, I; Razgaitis, KA; Sutton, BM; Walz, DT1
Ariyan, ZS; Fogt, SW; Heilman, RD; Matthews, RJ; Powers, LJ; Rippin, DJ1
Fenech, G; Forestieri, AM; Giordano, A; Monforte, MT; Previtera, T; Vigorita, MG; Zappala, C1
Counts, DF; Dutcher, JA; Whalen, JD; Wooley, PH1
Carlberg, C; Jagher, B; Missbach, M; Nayeri, S; Sigg, I; Wiesenberg, I1
Engelhardt, G; Homma, D; Schnitzler, C1
Cervero, F; García de la Rubia, P; Herrero, JF; Laird, JM1
Carlberg, C; Chiesi, M; Missbach, M; Pignat, W; Spanka, C; Wiesenberg, I1
Engelhardt, G; Mauz, A; Pairet, M; Schierok, H; Trummlitz, G; van Ryn, J1
Arimura, A; Hori, Y; Inagaki, M; Jyoyama, H; Kakudo, S; Kato, M; Kawai, S; Kobayashi, M; Koizumi, K; Matsumoto, S; Ohno, K; Ono, T; Suzuki, R; Tsuri, T; Yamada, K; Yasui, K1
Bishop-Bailey, D; Hashiramoto, A; Hla, T; Inoue, K; Kawahito, Y; Kohno, M; Kondo, M; Sano, H; Tsubouchi, Y; Yamada, R1
Helyes, Z; Horváth, A; Kéri, G; Németh, J; Oroszi, G; Pintér, E; Szolcsányi, J; Thán, M1
Carter, AJ; Cervero, F; Grauert, M; Laird, JM1
Goto, T; Ochi, T1
Dove, PA; Rosenthale, ME; Sandor, A; Shriver, DA; White, CB1
Gomarasca, P1
Hori, N; Imamura, A; Ohashi, M; Saito, T; Tsukamoto, G; Yoshino, K1
Busch, U; Engelhardt, G1
Becker, R; Cullen, E; Freter, K; LeClerq, T; Possanza, G; Wong, HC1
Benslay, DN; Ho, PP; Panetta, JA; Shadle, JK; Towner, RD1
Bartlett, RR; Schleyerbach, R; Thorwart, W; Weithmann, KU1
Benslay, DN; Bertsch, B; Ho, PP; Panetta, JA; Phillips, ML; Towner, RD; Wang, L1
Berkowitz, BA; DiMartino, MJ; Griswold, DE; Hanna, N; Poste, G1
Komoriya, K; Kunisawa, K; Nagata, I; Naruchi, T; Takeshita, T1
Bender, PE; DiMartino, M; Griswold, DE; Hill, DT; Lavanchy, P; Offen, PH; Razgaitis, K; Stringer, OD; Sutton, BM; Walz, DT1

Reviews

2 review(s) available for thiazoles and Adjuvant Arthritis

ArticleYear
Pyridinylimidazole based p38 MAP kinase inhibitors.
    Current topics in medicinal chemistry, 2002, Volume: 2, Issue:9

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Drug Design; Enzyme Inhibitors; Humans; Imidazoles; Indoles; Mitogen-Activated Protein Kinases; Oxazoles; p38 Mitogen-Activated Protein Kinases; Pyridines; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured

2002
[Meloxicam (Mobic): a review of its pharmacological and clinical profile].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2002, Volume: 120, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Clinical Trials as Topic; Cyclooxygenase 2; Enzyme Inhibitors; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Inflammation; Isoenzymes; Meloxicam; Membrane Proteins; Pain; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Rats; Thiazines; Thiazoles

2002

Trials

1 trial(s) available for thiazoles and Adjuvant Arthritis

ArticleYear
Analgesic effects of intramuscular administration of meloxicam in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis.
    American journal of veterinary research, 2009, Volume: 70, Issue:12

    Topics: Amazona; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Bird Diseases; Cross-Over Studies; Dose-Response Relationship, Drug; Injections, Intramuscular; Meloxicam; Thiazines; Thiazoles; Uric Acid

2009

Other Studies

56 other study(ies) available for thiazoles and Adjuvant Arthritis

ArticleYear
An Accord of Nuclear Receptor Expression in CD4
    ImmunoHorizons, 2019, 08-22, Volume: 3, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Antibodies; Arthritis, Experimental; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Collagen Type II; Cytokines; Female; Humans; Inflammation; Male; Mice; Mice, Inbred DBA; Phenylacetates; Receptors, Cytoplasmic and Nuclear; Retinoids; Synovial Fluid; Thiazoles; Thiosemicarbazones; Transcription, Genetic

2019
Drug-Disease Interaction: Effect of Inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid.
    Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arthritis, Experimental; Celecoxib; Cytochrome P-450 Enzyme System; Heart; Hydroxyeicosatetraenoic Acids; Inflammation; Kidney; Lactones; Male; Meloxicam; Rats; Rats, Sprague-Dawley; Sulfones; Thiazines; Thiazoles

2018
JTE-852, a novel spleen tyrosine kinase inhibitor, blocks immunoglobulin G-mediated cellular responses and autoimmune reactions in vivo.
    Life sciences, 2017, Dec-15, Volume: 191

    Topics: Aminopyridines; Animals; Arthritis, Experimental; Autoimmune Diseases; Autoimmunity; Cells, Cultured; Disease Models, Animal; Female; Humans; Immunoglobulin G; Male; Mast Cells; Monocytes; Passive Cutaneous Anaphylaxis; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Syk Kinase; Thiazoles

2017
11β-Hydroxysteroid dehydrogenase 1 inhibition attenuates collagen-induced arthritis.
    International immunopharmacology, 2013, Volume: 17, Issue:3

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Cytokines; Enzyme Inhibitors; Foot Joints; Humans; Immunoglobulin G; Male; Mice; Mice, Inbred DBA; NF-kappa B; Piperazines; Radiography; Sulfonamides; Synovial Membrane; Thiazoles

2013
Intra-articular anaesthesia mitigates established pain in experimental osteoarthritis: a preliminary study of gait impulse redistribution as a biomarker of analgesia pharmacodynamics.
    Osteoarthritis and cartilage, 2013, Volume: 21, Issue:9

    Topics: Anesthetics, Local; Animals; Anterior Cruciate Ligament Injuries; Anti-Inflammatory Agents, Non-Steroidal; Arthralgia; Arthritis, Experimental; Biomarkers; Disease Models, Animal; Dogs; Female; Femoral Fractures; Gait; Injections, Intra-Articular; Injections, Intradermal; Lidocaine; Male; Meloxicam; Osteoarthritis, Knee; Pilot Projects; Thiazines; Thiazoles; Weight-Bearing

2013
Intra-articular injection of the selective cyclooxygenase-2 inhibitor meloxicam (Mobic) reduces experimental osteoarthritis and nociception in rats.
    Osteoarthritis and cartilage, 2013, Volume: 21, Issue:12

    Topics: Animals; Anterior Cruciate Ligament Injuries; Arthritis, Experimental; Cartilage, Articular; Chondrocytes; Cyclooxygenase 2 Inhibitors; Extracellular Signal-Regulated MAP Kinases; Injections, Intra-Articular; JNK Mitogen-Activated Protein Kinases; Meloxicam; Mitogen-Activated Protein Kinases; Nociception; Osteoarthritis, Knee; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Synovial Membrane; Thiazines; Thiazoles

2013
Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases.
    Bioorganic & medicinal chemistry, 2013, Dec-15, Volume: 21, Issue:24

    Topics: Administration, Oral; Animals; Arthritis, Experimental; Class Ib Phosphatidylinositol 3-Kinase; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Male; Mice; Mice, Inbred DBA; Molecular Structure; Oxadiazoles; Phosphoinositide-3 Kinase Inhibitors; Structure-Activity Relationship; Thiazoles

2013
Rational Design of Benzylidenehydrazinyl-Substituted Thiazole Derivatives as Potent Inhibitors of Human Dihydroorotate Dehydrogenase with in Vivo Anti-arthritic Activity.
    Scientific reports, 2015, Oct-07, Volume: 5

    Topics: Animals; Arthritis, Experimental; Crystallography, X-Ray; Dihydroorotate Dehydrogenase; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors; Humans; Hydrogen Bonding; Male; Models, Molecular; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Wistar; Structure-Activity Relationship; Thiazoles

2015
Non-steroidal Anti-inflammatory Drugs Attenuate Hyperalgesia and Block Upregulation of Trigeminal Ganglionic Sodium Channel 1.7 after Induction of Temporomandibular Joint Inflammation in Rats.
    The Chinese journal of dental research, 2016, Volume: 19, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Diclofenac; Eating; Female; Freund's Adjuvant; Hyperalgesia; Ibuprofen; Meloxicam; NAV1.7 Voltage-Gated Sodium Channel; Nociception; Pain Threshold; Rats; Rats, Sprague-Dawley; Synovial Membrane; Temporomandibular Joint; Temporomandibular Joint Disorders; Thiazines; Thiazoles; Trigeminal Ganglion; Up-Regulation

2016
Cyclooxygenase-2 inhibition reverts the decrease in adiponectin levels and attenuates the loss of white adipose tissue during chronic inflammation.
    European journal of pharmacology, 2009, Apr-17, Volume: 608, Issue:1-3

    Topics: Adiponectin; Adipose Tissue, White; Animals; Arthritis, Experimental; Body Weight; Chronic Disease; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Insulin-Like Growth Factor I; Male; Meloxicam; Rats; Rats, Wistar; RNA, Messenger; Severity of Illness Index; Thiazines; Thiazoles; Tumor Necrosis Factor-alpha

2009
Inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice.
    European journal of pharmacology, 2009, Jun-24, Volume: 613, Issue:1-3

    Topics: Animals; Arthritis, Experimental; Benzamides; Biomarkers; Bone and Bones; Bone Resorption; Cartilage; Cathepsin K; Cathepsins; Collagen; Female; Humans; Inflammation; Mice; Protease Inhibitors; Thiazoles

2009
A novel transdermal patch incorporating meloxicam: in vitro and in vivo characterization.
    International journal of pharmaceutics, 2010, Jan-29, Volume: 385, Issue:1-2

    Topics: Acrylic Resins; Administration, Cutaneous; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Chemistry, Pharmaceutical; Diffusion; Disease Models, Animal; Dosage Forms; Drug Compounding; Drug Stability; Edema; Excipients; Freund's Adjuvant; Meloxicam; Mice; Mice, Hairless; Mycobacterium; Osteoarthritis; Permeability; Piroxicam; Povidone; Rats; Rats, Sprague-Dawley; Skin; Skin Absorption; Solubility; Technology, Pharmaceutical; Thiazines; Thiazoles; Tissue Adhesives

2010
Sensory and vascular changes in a rat monoarthritis model: prophylactic and therapeutic effects of meloxicam.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase Inhibitors; Freund's Adjuvant; Humans; Inflammation; Male; Meloxicam; Rats; Rats, Sprague-Dawley; Tarsus, Animal; Thiazines; Thiazoles

2010
DBM1285 suppresses tumor necrosis factor alpha production by blocking p38 mitogen-activated protein kinase/mitogen-activated protein kinase-activated protein kinase 2 signaling pathway.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 334, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Arthritis, Rheumatoid; Bone Marrow Cells; Cell Lineage; In Vitro Techniques; Inflammation; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Macrophages; Mice; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Pyrimidines; RNA, Messenger; Signal Transduction; Thiazoles; Tumor Necrosis Factor-alpha

2010
The selective sphingosine 1-phosphate receptor 1 agonist ponesimod protects against lymphocyte-mediated tissue inflammation.
    The Journal of pharmacology and experimental therapeutics, 2011, Volume: 337, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; CHO Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); Hypersensitivity, Delayed; Inflammation; Lymphocyte Count; Lymphocyte Subsets; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Monocytes; Rats; Rats, Inbred Lew; Rats, Wistar; Receptors, Lysosphingolipid; Thiazoles

2011
Modulation of cell recruitment by anti-inflammatory agents in antigen-induced arthritis.
    Annals of the rheumatic diseases, 2002, Volume: 61, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemokine CCL2; Cyclooxygenase Inhibitors; Diclofenac; Dinoprostone; Gene Expression Regulation; Interleukin-8; Leukocytes; Meloxicam; Neutrophil Infiltration; Ovalbumin; Rabbits; Thiazines; Thiazoles

2002
SUPPRESSION OF ADJUVANT-INDUCED ARTHRITIS IN RATS WITH 2-BUTOXYCARBONYLMETHYLENE-4-OXOTHIAZOLIDINE.
    British journal of pharmacology and chemotherapy, 1965, Volume: 24

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Binding Sites; Carrageenan; Foot Diseases; Formaldehyde; Freund's Adjuvant; Kaolin; Leukocyte Count; Pharmacology; Phenylbutazone; Rats; Research; Thiazoles; Toxicology; Tuberculin Test

1965
Novel p38 inhibitors with potent oral efficacy in several models of rheumatoid arthritis.
    Bioorganic & medicinal chemistry letters, 2004, Jul-05, Volume: 14, Issue:13

    Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Collagen; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Lipopolysaccharides; Mice; Oxazoles; p38 Mitogen-Activated Protein Kinases; Pyridines; Rats; Structure-Activity Relationship; Thiazoles; Tumor Necrosis Factor-alpha

2004
Oral and nasal administration of chicken type II collagen suppresses adjuvant arthritis in rats with intestinal lesions induced by meloxicam.
    World journal of gastroenterology, 2004, Nov-01, Volume: 10, Issue:21

    Topics: Administration, Intranasal; Administration, Oral; Animals; Arthritis, Experimental; Cell Division; Chickens; Collagen Type II; Growth Inhibitors; Hindlimb; Intestinal Diseases; Intestines; Joints; Male; Meloxicam; Peroxidase; Rats; Rats, Sprague-Dawley; Synovial Membrane; Thiazines; Thiazoles

2004
Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors.
    Bioorganic & medicinal chemistry letters, 2004, Dec-20, Volume: 14, Issue:24

    Topics: Administration, Oral; Amides; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Models, Molecular; Molecular Structure; Rats; src-Family Kinases; Structure-Activity Relationship; Thiazoles

2004
Pharmacokinetic-pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint.
    American journal of veterinary research, 2004, Volume: 65, Issue:11

    Topics: Animals; Arthritis, Experimental; Biomechanical Phenomena; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Endpoint Determination; Horse Diseases; Horses; Lameness, Animal; Meloxicam; Models, Biological; Thiazines; Thiazoles

2004
Synthesis and biological activities of 4-phenyl-5-pyridyl-1,3-thiazole derivatives as p38 MAP kinase inhibitors.
    Chemical & pharmaceutical bulletin, 2005, Volume: 53, Issue:4

    Topics: Animals; Antibodies; Arthritis, Experimental; Cell Line; Chemical Phenomena; Chemistry, Physical; Collagen; Enzyme Inhibitors; Humans; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Molecular Conformation; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Structure-Activity Relationship; Thiazoles; Tumor Necrosis Factor-alpha

2005
Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase.
    Journal of medicinal chemistry, 2005, Jul-14, Volume: 48, Issue:14

    Topics: Acetonitriles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Experimental; Benzothiazoles; Humans; JNK Mitogen-Activated Protein Kinases; Jurkat Cells; Male; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Rats; Structure-Activity Relationship; Thiazoles; Tumor Necrosis Factor-alpha

2005
Novel inhibitor of p38 MAP kinase as an anti-TNF-alpha drug: discovery of N-[4-[2-ethyl-4-(3-methylphenyl)-1,3-thiazol-5-yl]-2-pyridyl]benzamide (TAK-715) as a potent and orally active anti-rheumatoid arthritis agent.
    Journal of medicinal chemistry, 2005, Sep-22, Volume: 48, Issue:19

    Topics: Administration, Oral; Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Benzamides; Biological Availability; Cell Line; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Humans; In Vitro Techniques; Isoenzymes; Male; Mice; Microsomes; Models, Molecular; Monocytes; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Thiazoles; Tumor Necrosis Factor-alpha

2005
2-aminothiazole as a novel kinase inhibitor template. Structure-activity relationship studies toward the discovery of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1- piperazinyl)]-2-methyl-4-pyrimidinyl]amino)]-1,3-thiazole-5-carboxamide (dasatin
    Journal of medicinal chemistry, 2006, Nov-16, Volume: 49, Issue:23

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cell Proliferation; Chronic Disease; Dasatinib; Female; Humans; In Vitro Techniques; Inflammation; Interleukin-2; Lipopolysaccharides; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Molecular; Protein Binding; Pyrimidines; Rats; Rats, Inbred Lew; src-Family Kinases; Structure-Activity Relationship; T-Lymphocytes; Thiazoles; Tumor Necrosis Factor-alpha

2006
Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation.
    American journal of physiology. Endocrinology and metabolism, 2007, Volume: 292, Issue:6

    Topics: Animals; Arthritis, Experimental; Cachexia; Chronic Disease; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Enzyme Activation; Gene Expression; Growth Hormone; Indomethacin; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Liver; Male; Meloxicam; Muscle Proteins; Muscle, Skeletal; Pituitary Gland; Rats; Rats, Wistar; RNA, Messenger; SKP Cullin F-Box Protein Ligases; Thiazines; Thiazoles; Tripartite Motif Proteins; Tumor Necrosis Factor-alpha; Ubiquitin-Protein Ligases; Weight Gain

2007
Antinociceptive profile of a selective metabotropic glutamate receptor 1 antagonist YM-230888 in chronic pain rodent models.
    European journal of pharmacology, 2007, Sep-24, Volume: 571, Issue:1

    Topics: Analgesics; Animals; Arthritis, Experimental; Benzimidazoles; Binding, Competitive; Cell Line; Cells, Cultured; Chronic Disease; Cycloheptanes; Dose-Response Relationship, Drug; Humans; Kinetics; Ligation; Molecular Structure; Motor Activity; Pain; Pain Measurement; Pyrimidines; Radioligand Assay; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Metabotropic Glutamate; Spinal Nerves; Thiazoles; Tritium

2007
Photodynamic therapy using talaporfin sodium for synovial membrane from rheumatoid arthritis patients and collagen-induced arthritis rats.
    Clinical rheumatology, 2008, Volume: 27, Issue:6

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Coloring Agents; Disease Models, Animal; Fibroblasts; Humans; Injections, Intra-Articular; Laser Therapy; Male; Mice; Mice, SCID; Photosensitizing Agents; Phototherapy; Porphyrins; Radiography; Rats; Rats, Inbred Lew; Synovial Membrane; Tetrazolium Salts; Thiazoles; Transplantation, Heterologous

2008
The orally-active and selective c-Fms tyrosine kinase inhibitor Ki20227 inhibits disease progression in a collagen-induced arthritis mouse model.
    European journal of immunology, 2008, Volume: 38, Issue:1

    Topics: Animals; Arthritis, Experimental; Blotting, Western; Bone and Bones; Cytokines; Disease Progression; Flow Cytometry; Inflammation; Macrophage Colony-Stimulating Factor; Male; Mice; Osteoclasts; Phenylurea Compounds; Protein Kinase Inhibitors; Spleen; Thiazoles

2008
Effect of inflammation on kidney function and pharmacokinetics of COX-2 selective nonsteroidal anti-inflammatory drugs rofecoxib and meloxicam.
    Journal of applied toxicology : JAT, 2008, Volume: 28, Issue:7

    Topics: Administration, Oral; Animals; Area Under Curve; Arthritis, Experimental; Arthritis, Rheumatoid; Cyclooxygenase 2 Inhibitors; Kidney; Kidney Function Tests; Lactones; Male; Meloxicam; Rats; Rats, Sprague-Dawley; Sulfones; Thiazines; Thiazoles

2008
A comparative study of the antiinflammatory activity of fentiazac and its major metabolite, p-hydroxy fentiazac.
    Agents and actions, 1984, Volume: 15, Issue:3-4

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Arachidonic Acids; Arthritis; Arthritis, Experimental; Macrophages; Male; Rats; Rats, Inbred Strains; Thiazoles

1984
Antiinflammatory activity of 5,6-diaryl-2,3-dihydroimidazo[2,1-b]thiazoles. Isomeric 4-pyridyl and 4-substituted phenyl derivatives.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Drug Evaluation, Preclinical; Imidazoles; Indicators and Reagents; Isomerism; Models, Molecular; Rats; Structure-Activity Relationship; Thiazoles; X-Ray Diffraction

1984
Effect of structural change on acute toxicity and antiinflammatory activity in a series of imidazothiazoles and thiazolobenzimidazoles.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Chemical Phenomena; Chemistry; Imidazoles; Lethal Dose 50; Locomotion; Male; Mice; Muscle Tonus; Nervous System; Orientation; Rats; Structure-Activity Relationship; Thiazoles

1981
3,3'-Bi-[1,3-thiazolidine-4-one] system. VII. Synthesis and SARS of some 2-heteroaryl derivatives with antiinflammatory and related activities.
    Farmaco (Societa chimica italiana : 1989), 1994, Volume: 49, Issue:1

    Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Edema; Magnetic Resonance Spectroscopy; Male; Mice; Pain; Pain Measurement; Rats; Rats, Wistar; Spectrophotometry, Infrared; Stomach Ulcer; Structure-Activity Relationship; Thiazoles

1994
The influence of a peptide sequence from PF-4 (CT-112) on type II collagen-induced arthritis in mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44 Suppl 2

    Topics: Aldehyde Reductase; Amino Acid Sequence; Animals; Arthritis, Experimental; Collagen; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Foot; Immunohistochemistry; Mice; Mice, Inbred DBA; Molecular Sequence Data; Thiazoles; Thiazolidinediones

1995
Thiazolidine diones, specific ligands of the nuclear receptor retinoid Z receptor/retinoid acid receptor-related orphan receptor alpha with potent antiarthritic activity.
    The Journal of biological chemistry, 1996, Jun-07, Volume: 271, Issue:23

    Topics: Acetamides; Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Autoimmune Diseases; Ligands; Male; Melatonin; Nuclear Receptor Subfamily 1, Group F, Member 1; Rats; Rats, Inbred Lew; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Receptors, Retinoic Acid; Structure-Activity Relationship; Thiazoles; Thiosemicarbazones; Trans-Activators

1996
Meloxicam: a potent inhibitor of adjuvant arthritis in the Lewis rat.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Blood Proteins; Blood Sedimentation; Bone and Bones; Cartilage, Articular; Dose-Response Relationship, Drug; Foot; Hindlimb; Joints; Male; Meloxicam; Radiography; Rats; Rats, Inbred Lew; Spleen; Thiazines; Thiazoles

1995
Analgesic activity of the novel COX-2 preferring NSAID, meloxicam in mono-arthritic rats: central and peripheral components.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Carrageenan; Female; Meloxicam; Rats; Rats, Wistar; Reflex; Thiazines; Thiazoles

1997
Specific activation of the nuclear receptors PPARgamma and RORA by the antidiabetic thiazolidinedione BRL 49653 and the antiarthritic thiazolidinedione derivative CGP 52608.
    Molecular pharmacology, 1998, Volume: 53, Issue:6

    Topics: 3T3 Cells; Animals; Arthritis, Experimental; Cell Nucleus; Dexamethasone; Hypoglycemic Agents; Insulin Resistance; Leptin; Male; Mice; Proteins; Rats; Rats, Inbred Lew; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Rosiglitazone; Thiazoles; Thiazolidinediones; Thiosemicarbazones; Transcription Factors; Triglycerides

1998
Differential inhibition of cyclooxygenases-1 and -2 by meloxicam and its 4'-isomer.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47, Issue:6

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Isoenzymes; Male; Meloxicam; Prostaglandin-Endoperoxide Synthases; Rats; Stomach Ulcer; Thiazines; Thiazoles

1998
Novel antiarthritic agents with 1,2-isothiazolidine-1,1-dioxide (gamma-sultam) skeleton: cytokine suppressive dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase.
    Journal of medicinal chemistry, 2000, May-18, Volume: 43, Issue:10

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Blood Platelets; Cyclic S-Oxides; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Edema; Female; Gastric Mucosa; Humans; Interleukin-1; Isoenzymes; Leukotriene B4; Lipoxygenase Inhibitors; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Structure-Activity Relationship; Synovial Membrane; Thiazoles

2000
15-deoxy-delta(12,14)-PGJ(2) induces synoviocyte apoptosis and suppresses adjuvant-induced arthritis in rats.
    The Journal of clinical investigation, 2000, Volume: 106, Issue:2

    Topics: Animals; Apoptosis; Arthritis; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Chromans; Female; Humans; Ligands; Osteoarthritis; Prostaglandin D2; Rats; Rats, Inbred Lew; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Synovial Membrane; Thiazoles; Thiazolidinediones; Tissue Distribution; Transcription Factors; Troglitazone

2000
Anti-inflammatory effect of synthetic somatostatin analogues in the rat.
    British journal of pharmacology, 2001, Volume: 134, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Bradykinin; Capillary Permeability; Dextrans; Diclofenac; Dose-Response Relationship, Drug; Evans Blue; Female; Hindlimb; In Vitro Techniques; Inflammation; Injections, Intraperitoneal; Meloxicam; Neuropeptides; Peptides, Cyclic; Rats; Rats, Wistar; Somatostatin; Thiazines; Thiazoles; Time Factors; Trachea; Treatment Outcome

2001
Analgesic activity of a novel use-dependent sodium channel blocker, crobenetine, in mono-arthritic rats.
    British journal of pharmacology, 2001, Volume: 134, Issue:8

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzomorphans; Dose-Response Relationship, Drug; Female; Freund's Adjuvant; Hyperalgesia; Inflammation; Meloxicam; Mexiletine; Pain; Pain Measurement; Posture; Rats; Rats, Wistar; Sodium Channel Blockers; Thiazines; Thiazoles

2001
Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis.
    British journal of pharmacology, 2002, Volume: 135, Issue:3

    Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Chronic Disease; Collagen; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Edema; Female; Hindlimb; Isoenzymes; Membrane Proteins; Piperazines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred Lew; Thiazoles; Thromboxane B2

2002
A profile of the gastrointestinal toxicity of aspirin, indomethacin, oxaprozin, phenylbutazone, and fentiazac in arthritic and Lewis normal rats.
    Toxicology and applied pharmacology, 1977, Volume: 42, Issue:1

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Aspirin; Body Weight; Gastrointestinal Diseases; Indomethacin; Intestine, Small; Male; Oxazoles; Phenylbutazone; Propionates; Rats; Stomach; Thiazoles; Time Factors

1977
[Fentiazac in arthritis due to sodium urate].
    Bollettino chimico farmaceutico, 1976, Volume: 115, Issue:11

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Dogs; Male; Sodium; Thiazoles; Uric Acid

1976
Novel disease-modifying antirheumatic drugs. I. Synthesis and antiarthritic activity of 2-(4-methylphenyl)benzothiazoles.
    Chemical & pharmaceutical bulletin, 1992, Volume: 40, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Hemagglutination; Hypersensitivity, Delayed; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Inbred F344; Thiazoles

1992
Distribution of [14C]meloxicam in joints of rats with adjuvant arthritis.
    Drugs under experimental and clinical research, 1990, Volume: 16, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Autoradiography; Carbon Radioisotopes; Joints; Male; Meloxicam; Rats; Staining and Labeling; Thiazines; Thiazoles

1990
Bis basic substituted diaminobenzobisthiazoles as potential antiarthritic agents.
    Journal of medicinal chemistry, 1992, Jan-24, Volume: 35, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Edema; Hemolytic Plaque Technique; Male; Mice; Mice, Inbred AKR; Molecular Structure; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazoles

1992
Anti-inflammatory effects of LY221068 and LY269415.
    Agents and actions, 1991, Volume: 34, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Calcimycin; Guinea Pigs; Humans; In Vitro Techniques; Lipid Peroxidation; Lipoxygenase Inhibitors; Prostaglandin-Endoperoxide Synthases; Rabbits; Rats; Thiazoles; Thiazolidines

1991
Pharmacological profile of HWA-131, a novel antiinflammatory agent with immunomodulating properties.
    Agents and actions, 1990, Volume: 29, Issue:1-2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Arthritis, Experimental; Arthus Reaction; Cell Division; Collagen; Prednisolone; Rats; Thiazoles; Triazines

1990
The anti-inflammatory effects of LY178002 and LY256548.
    Agents and actions, 1989, Volume: 27, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Arthritis; Arthritis, Experimental; Cyclooxygenase Inhibitors; Freund's Adjuvant; Guinea Pigs; In Vitro Techniques; Neutrophils; Thiazoles; Thiazolidines

1989
Pharmacologic characterization of the antiinflammatory properties of a new dual inhibitor of lipoxygenase and cyclooxygenase.
    Agents and actions, 1987, Volume: 20, Issue:1-2

    Topics: Administration, Oral; Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cyclooxygenase Inhibitors; Edema; Imidazoles; Lipoxygenase Inhibitors; Male; Rats; Rats, Inbred Lew; Thiazoles

1987
Anti-arthritic and immunoregulatory effects of TI-31 on collagen-induced arthritis.
    Japanese journal of pharmacology, 1987, Volume: 45, Issue:3

    Topics: Animals; Antibody Formation; Arthritis; Arthritis, Experimental; Collagen; Dose-Response Relationship, Drug; Immunity, Cellular; Immunoglobulin G; Immunosuppressive Agents; Male; Rats; Rats, Inbred Strains; Thiazoles

1987
5,6-Diaryl-2,3-dihydroimidazo[2,1-b]thiazoles: a new class of immunoregulatory antiinflammatory agents.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:9

    Topics: Animals; Arthritis; Arthritis, Experimental; Chemical Phenomena; Chemistry; Dermatitis, Contact; Hemagglutination Tests; Imidazoles; Levamisole; Male; Mice; Mice, Inbred C57BL; Oxazolone; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazoles

1985