thiazoles has been researched along with Acute Myelogenous Leukemia in 97 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (4.12) | 18.7374 |
| 1990's | 5 (5.15) | 18.2507 |
| 2000's | 21 (21.65) | 29.6817 |
| 2010's | 65 (67.01) | 24.3611 |
| 2020's | 2 (2.06) | 2.80 |
| Authors | Studies |
|---|---|
| Bashash, D; Riyahi, N; Safaroghli-Azar, A; Sayyadi, M; Sheikh-Zeineddini, N | 1 |
| Asada, S; Fukuyama, T; Goyama, S; Hayashi, Y; Kitamura, T; Liu, X; Matsuda, K; Matsumoto, A; Mizukawa, B; O'Brien, E; Sashida, G; Shibata, T; Takizawa, H; Tamura, M; Tanaka, Y; Wunderlich, M; Yamasaki, S; Yamazaki, S | 1 |
| Bejarano, I; de la Cruz-Martínez, F; Espino, J; Fernández-Delgado, E; Franco, L; Galán, C; Luna-Giles, F; Viñuelas-Zahínos, E | 1 |
| Chang, LS; Chiou, JT; Huang, CH; Lee, YC; Shi, YJ; Wang, LJ | 1 |
| Paubelle, E; Thomas, X; Zylbersztejn, F | 1 |
| Bartholdy, BA; Choudhary, GS; Dong, B; Garner, TP; Gavathiotis, E; Kopp, F; Lopez, A; Mitchell, K; Narayanagari, SR; Reyna, DE; Sridharan, A; Steidl, U; Verma, A; Walensky, LD | 1 |
| Itoh, M; Ohtaka, M; Tohda, S | 1 |
| Acton, G; Carella, AM; Cortes, JE; Craig, AR; Craig, MD; Egyed, M; Fox, JA; Horst, HA; Jabbour, E; Kantarjian, HM; Klimek, VM; Krug, U; Lancet, JE; Pigneux, A; Ravandi, F; Récher, C; Ritchie, EK; Sayar, H; Schiller, GJ; Smith, JA; Strickland, SA; Stuart, RK; Vey, N; Ward, R | 1 |
| Chen, C; Ge, J; Hu, Z; Jiang, Z; Li, F; Liang, X; Liu, J; Liu, Q; Liu, X; Wang, A; Wang, B; Wang, L; Wang, W; Wang, Y; Yu, K; Zhang, S; Zou, F | 1 |
| Che, F; Gui, C; Huang, J; Wang, C; Zhang, L | 1 |
| Gajda, M; Jasek-Gajda, E; Jasińska, M; Lis, GJ; Litwin, JA | 1 |
| Cai, Z; Han, X; He, D; He, J; Wang, G; Wu, W; Yang, Y; Yao, S; Yu, R; Zhao, Y; Zheng, G | 1 |
| Armstrong, SA; Barbosa, K; Bohlander, SK; Chen, BR; Deshpande, A; Deshpande, AJ; Dixon, J; Dutta, S; Ghosh, A; Sun, Y; Weetall, M | 1 |
| Edwards, H; Ge, Y; Knight, T; Lin, H; Liu, F; Su, Y; Sun, L; Taub, JW; Wang, G; Wang, Y | 1 |
| Jin, Y; Liu, H; Meng, H; Qian, W; Yang, C; Yang, X; You, L | 1 |
| Freeman, C; Giles, F; Keane, N; Swords, R | 1 |
| Agrawal, S; Baruchel, A; Beverloo, BB; den Boer, ML; Dworzak, M; Kearns, PR; Lancaster, DL; Lehrnbecher, T; Manos, G; Mechinaud, F; Pieters, R; Reinhardt, D; Rizzari, C; Rosenberg, J; Strauss, L; van der Velden, VH; Zwaan, CM | 1 |
| Fang, Y; He, Q; Jing, H; Lin, M; Luo, P; Yang, B; Ying, M; Zhong, L; Zhou, X | 1 |
| Bhatia, R; Dos Santos, C; Forman, SJ; Ho, YW; Kuo, YH; Lin, A; Liu, H; McDonald, T | 1 |
| Bartholomae, S; Bullinger, L; Corbacioglu, S; Debatin, KM; Herrmann, MD; Holzmann, K; Lennerz, JK; Westhoff, MA | 1 |
| Cortes, J; Galanis, A; Levis, M; Ma, H; Rajkhowa, T; Ramachandran, A; Small, D | 1 |
| Arai, H; Handa, T; Iso, H; Mitani, K; Nagasawa, F; Nakamura, Y; Sasaki, K; Takahashi, W; Tokita, K; Tsurumi, S | 1 |
| Lancet, JE | 1 |
| Kurosu, T; Miura, O; Nagao, T; Nogami, A; Oshikawa, G; Tohda, S; Umezawa, Y; Yamamoto, M | 1 |
| Cao, J; Fang, Y; He, Q; Liu, L; Qi, X; Xie, N; Yang, B; Ying, M; Zhong, L | 1 |
| Albrecht, H; Basnet, SK; Diab, S; Kumarasiri, M; Lam, F; Li, P; Milne, R; Sykes, MJ; Teo, T; Wang, S; Yu, M | 1 |
| Gong, Y; Guo, Y; Lin, J; Shan, Q; Shi, F; Shi, R; Yang, X | 1 |
| Heo, SK; Jo, JC; Kim, H; Noh, EK; Park, JH; Yoon, DJ | 1 |
| Chen, JJ; Fang, ZG; Lin, DJ; Liu, LL; Liu, Q; Long, ZJ; Pan, XN; Wang, LX; Xiao, RZ | 1 |
| Chen, T; Craig, AR; Cripe, LD; Fox, JA; Hawtin, R; Karp, JE; Lancet, JE; Leavitt, RD; Maris, MB; Michelson, GC; Ravandi, F; Roboz, GJ; Stuart, RK | 1 |
| Borthakur, G; Cooper, MA; Costa, LJ; Cripe, LD; Dakhil, SR; Fox, JA; Leavitt, RD; Maris, MB; Mason, J; Michelson, GC; Ravandi, F; Shami, PJ; Stock, W; Stone, RM; Strickland, SA; Stuart, RK; Turturro, F | 1 |
| Galanis, A; Levis, M | 1 |
| Accordi, B; Aveic, S; Basso, G; Locatelli, F; Masetti, R; Micalizzi, C; Pigazzi, M; Santoro, N; Viola, G | 1 |
| Aikawa, Y; Akashi, K; Cleary, ML; Katsumoto, T; Kitabayashi, I; Shima, Y; Shino, M; Stanley, ER; Tenen, DG; Yamagata, K | 1 |
| Endo, A; Lamond, AI; Ly, T | 1 |
| Burnett, AK; Clark, RE; Dennis, M; Dignum, H; Hemmaway, C; Hills, RK; Kjeldsen, L; McMullin, MF; Milligan, D; Panoskaltsis, N; Russell, N; Thomas, IF | 1 |
| Altman, JK; Beauchamp, EM; Bliss-Moreau, M; Blyth, G; Colamonici, M; Giles, FJ; Platanias, LC; Saleiro, D; Szilard, A | 1 |
| Hotinski, AK; Lewis, ID; Ross, DM | 1 |
| Bornhäuser, M | 1 |
| Acton, G; Carella, AM; Cortes, J; Craig, AR; Craig, MD; Damon, L; Derigs, HG; Erba, HP; Fox, JA; Gaidano, G; Havelange, V; Heuser, M; Hogge, D; Horst, HA; Jabbour, E; Kantarjian, HM; Klimek, VM; Lancet, JE; Maertens, J; Mehta, C; Odenike, O; Pigneux, A; Powell, BL; Ravandi, F; Recher, C; Ritchie, EK; Roboz, GJ; Sayar, H; Schiller, GJ; Smith, JA; Strickland, SA; Stuart, RK; Thomas, X; Vey, N; Ward, R; Wei, A | 1 |
| Fujii, S; Miura, I; Tanaka, H | 1 |
| Andreeff, M; Chachad, D; Ishizawa, J; Kimura, S; Kojima, K; Kornblau, SM; Maeda, A; Nishida, Y; Qiu, YH | 1 |
| Ravandi, F; Short, NJ | 1 |
| Fox, JA; Jamieson, GC; Poi, M; Strickland, SA | 1 |
| Benton, CB; Ravandi, F | 1 |
| Akin, C; Cortes, J; Faderl, S; Garcia-Manero, G; Kantarjian, H; Manshouri, T; O'Brien, S; Pardanani, A; Tefferi, A; Thomas, D; Verstovsek, S | 1 |
| Birgens, H; Brown, Pde N; Dalseg, AM; Dufva, IH; Hasselbalch, HC; Jensen, MK; Vangsted, A | 1 |
| Ingley, E; Klinken, SP; Lucet, IS; Rossjohn, J; Williams, NK | 1 |
| Bhalla, K; Corless, CL; Fiskus, W; Heinrich, MC; Jillella, A; Kepten, I; Lewis, G; Manaloor, E; Ramalingam, P; Savage, N; Ustun, C | 1 |
| Facchini, G; Ferrari, F; Gemelli, C; Grande, A; Lymboussaki, A; Mavilio, F; Testa, A | 1 |
| Bendit, I; de Alencar Fischer Chamone, D; de Mello Conchon, MR; Dias, L; Dorlhiac-Llacer, PE; Ferreira, P; Kumeda, C; Lima, W | 1 |
| Lohiya, NK; Pal, R; Talwar, GP; Vishwakarma, R; Vyas, HK | 1 |
| Tallman, M | 1 |
| Bardet, V; Bouscary, D; Chapuis, N; Dreyfus, F; Green, AS; Ifrah, N; Lacombe, C; Mayeux, P; Park, S; Tamburini, J; Uzunov, M; Willems, L | 1 |
| Berridge, MV; Davis, JE; Herst, PM; Neeson, P; Ritchie, DS | 1 |
| Johnson, DE; Kropf, PL; Redner, RL; Wang, L; Zang, Y | 1 |
| Frankel, AE; Hogge, DE; Kim, HP | 1 |
| Billström, R; Ekblom, M; Fioretos, T; Larsson, N; Lassen, C; Lilljebjörn, H; Richter, J | 1 |
| Becker, H; Chevalier, N; Gärtner, F; Hübner, J; Lübbert, M; Maul-Pavicic, A; Pantic, M; Schmitt-Gräff, A; Solari, ML; Wäsch, R | 1 |
| Burnett, AK; Coles, SJ; Knapper, S; Walsby, EJ | 1 |
| Baldi, A; Bianciotti, LG; Copsel, S; Davio, C; Diez, F; Garcia, C; Russel, FG; Shayo, C; Vermeulem, M | 1 |
| Burnett, AK; Lazenby, M; Pepper, C; Walsby, E | 1 |
| Chen, Y; Li, D; Li, S; Peng, C | 1 |
| Amrein, PC | 1 |
| Allen, RS; Chen, T; Cripe, LD; Fox, JA; Giles, FJ; Kantarjian, HM; Karp, JE; Lancet, JE; List, AF; Michelson, GC; Ravandi, F; Ricklis, RM | 1 |
| Adachi, JA; Koo, HL; Siddiq, DM; Viola, GM | 1 |
| Adamia, S; Barrett, R; Daley, JF; Fox, E; Frank, D; Griffin, JD; Nelson, E; Ray, A; Sattler, M; Weisberg, E; Zhang, C | 1 |
| Bizzarri, B; Bolasco, A; Carradori, S; Cavaliere, C; D'Agnano, I; Del Bufalo, D; Desideri, M; Filetici, P; Gabellini, C; Maresca, G; Nescatelli, R; Pelosi, A; Ragazzoni, Y; Ricci-Vitiani, L; Rizzo, MG; Secci, D; Trisciuoglio, D | 1 |
| Feldman, EJ | 1 |
| Ahmed, SI; Al-akhrass, F; Rallapalli, V; Rodriguez, GH; Safdar, A | 1 |
| Celeghini, C; Melloni, E; Norcio, A; Secchiero, P; Voltan, R; Zauli, G | 1 |
| Bolton, E; Cerny-Reiterer, S; Cramer, K; Dorrance, A; Eaves, CJ; Flis, S; Glodkowska-Mrowka, E; Hochhaus, A; Holyoake, TL; Hoser, G; Hughes, TP; Kopinski, PK; Koptyra, M; Ngaba, D; Nieborowska-Skorska, M; Penserga, T; Ray, R; Reddy, MM; Richardson, C; Sattler, M; Skorski, T; Stoklosa, T; Valent, P; van der Kuip, H; Wiktor-Jedrzejczak, W; Williams, DA | 1 |
| Bronson, R; Christie, AL; Daley, JF; Galinsky, I; Gray, N; Griffin, JD; Hur, W; Kung, AL; Liu, Q; Mitsiades, C; Nelson, E; Sanda, T; Sattler, M; Smith, R; Stone, R; Weisberg, E; Zhao, Z | 1 |
| Kanzaki, S; Kure, A; Okuno, K; Sano, H; Tamoto, N; Ueyama, J | 1 |
| Abbas, JA; Stuart, RK | 1 |
| Dervenoulas, I; Dimitriadis, G; Girkas, K; Karakitsos, P; Kontsioti, F; Kottaridi, C; Mpakou, VE; Papageorgiou, S; Pappa, V; Spathis, A | 1 |
| Negoro, E; Nishi, R; Takemura, H; Ueda, T; Yamauchi, T | 1 |
| Balcerska, A; Balwierz, W; Chybicka, A; Debski, R; Kowalczyk, J; Matysiak, M; Rokicka-Milewska, R; Sońta-Jakimczyk, D; Styczyński, J; Wachowiak, J; Wysocki, M | 1 |
| Balcerska, A; Balwierz, W; Chybicka, A; Debski, R; Kowalczyk, J; Kurylak, A; Matysiak, M; Rokicka-Milewska, R; Sońta-Jakimczyk, D; Styczyński, J; Wachowiak, J; Wysocki, M | 1 |
| Debski, R; Juraszewska, E; Malinowska, I; Mazur, B; Ploszynska, A; Stanczak, E; Stefaniak, J; Styczynski, J; Szczepanski, T; Wysocki, M | 1 |
| Morikawa, K; Morikawa, S; Nakano, A; Torii, I | 1 |
| Huang, N; Peng, H; Qi, J; Wang, J; Xie, P; Xu, C; Yang, C | 1 |
| Creutzig, U; Langebrake, C; Puhlmann, U; Reinhardt, D; Ruedell, G; Schaefer, D; Schuermann, P; Vorwerk, H; Ziemann, C | 1 |
| Schinköthe, T; Staib, P; Strunk, T; Tiehen, J | 1 |
| Czyzewski, K; Styczynski, J; Wysocki, M | 1 |
| Bandettini, R; Cappelli, B; Castagnola, E; Coccia, C; Di Martino, D; Faraci, M; Lanino, E; Moroni, C; Morreale, G; Terranova, MP | 1 |
| Chi, HS; Choi, SJ; Im, HJ; Jang, S; Jun, KR; Lee, JH; Lee, KH; Moon, HN; Park, CJ; Seo, JJ | 1 |
| Alexander, P; Dobbie, D; Forbes, P; Powles, R | 1 |
| Efferth, T; Fabry, U; Glatte, P; Osieka, R | 1 |
| Löwenberg, B; Sonneveld, P; te Boekhorst, PA | 1 |
| Chen, LM; Huang, SH; Hwang, WS; Tseng, MT; Wang, CC | 1 |
| Choi, CH; Kim, HS; Lee, TB | 1 |
| Lambert, E; Rees, JK; Twentyman, PR | 1 |
| Advani, S; Chavan, S; Chitnis, M; Hegde, U; Juvekar, A | 1 |
| Ball, ED; Bigelow, N; Cornwell, GG; Davis, BH; Mills, L | 1 |
| Sargent, JM; Taylor, CG | 1 |
| Deli, E; Kiss, Z; Koeffler, HP; Kuo, JF; Pettit, GR; Shoji, M; Vogler, WR | 1 |
11 review(s) available for thiazoles and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
The preclinical discovery of vosaroxin for the treatment of acute myeloid leukemia.
Topics: Adult; Aged; Animals; Antineoplastic Agents; Apoptosis; DNA Breaks, Double-Stranded; Drug Evaluation, Preclinical; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia, Myeloid, Acute; Naphthyridines; Thiazoles; Topoisomerase Inhibitors | 2017 |
A Bayesian Network Meta-Analysis Comparing the Efficacies of Eleven Novel Therapies with the Common Salvage Regimen for Relapsed or Refractory Acute Myeloid Leukemia.
Topics: Bayes Theorem; Cytarabine; Disease-Free Survival; Histone Deacetylase Inhibitors; Humans; Leukemia, Myeloid, Acute; Naphthyridines; Neoplasm Recurrence, Local; Odds Ratio; Pyrazoles; Pyrimidines; Remission Induction; Salvage Therapy; Survival Rate; Thiazoles | 2018 |
New agents: great expectations not realized.
Topics: Aminoglycosides; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Benzothiazoles; Cytosine; Gemtuzumab; Humans; Hydroxamic Acids; Leukemia, Myeloid, Acute; Naphthyridines; Phenylurea Compounds; Prognosis; Randomized Controlled Trials as Topic; Recurrence; Remission Induction; Staurosporine; Survival Analysis; Thiazoles; Treatment Failure; Vorinostat | 2013 |
Vosaroxin is a novel topoisomerase-II inhibitor with efficacy in relapsed and refractory acute myeloid leukaemia.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Cytarabine; Humans; Leukemia, Myeloid, Acute; Naphthyridines; Recurrence; Thiazoles; Topoisomerase Inhibitors; Treatment Failure | 2015 |
[Development of Ph negative acute myeloid leukemia in a patient with minor-BCR/ABL positive chronic myeloid leukemia achieving a partial cytogenetic response during tyrosine kinase inhibitor treatment].
Topics: Aged; Benzamides; Cytogenetic Analysis; Dasatinib; Fatal Outcome; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Remission Induction; Thiazoles | 2015 |
The safety and efficacy of vosaroxin in patients with first relapsed or refractory acute myeloid leukemia - a critical review.
Topics: Age Factors; Animals; Antineoplastic Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Humans; Leukemia, Myeloid, Acute; Naphthyridines; Recurrence; Retreatment; Thiazoles; Treatment Outcome | 2016 |
Molecular and Pharmacologic Properties of the Anticancer Quinolone Derivative Vosaroxin: A New Therapeutic Agent for Acute Myeloid Leukemia.
Topics: Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Double-Blind Method; Haplorhini; Humans; Leukemia, Myeloid, Acute; Mice; Middle Aged; Naphthyridines; Quinolones; Rats; Thiazoles | 2016 |
Targeting acute myeloid leukemia with TP53-independent vosaroxin.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Leukemia, Myeloid, Acute; Naphthyridines; Thiazoles; Treatment Outcome; Tumor Suppressor Protein p53 | 2017 |
[Novel medical treatment modalities in hematology].
Topics: Aminoglycosides; Anemia, Hemolytic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Benzamides; Benzoates; Boronic Acids; Bortezomib; Carbazoles; Carrier Proteins; Cyclophosphamide; Dasatinib; Furans; Gemtuzumab; Hematologic Diseases; Humans; Hydrazines; Imatinib Mesylate; Immunologic Factors; Indoles; Lenalidomide; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Piperazines; Purpura, Thrombocytopenic; Pyrazines; Pyrazoles; Pyrimidines; Receptors, Fc; Recombinant Fusion Proteins; Rituximab; Thalidomide; Thiazoles; Thrombopoietin; Vidarabine | 2008 |
The potential for dasatinib in treating chronic lymphocytic leukemia, acute myeloid leukemia, and myeloproliferative neoplasms.
Topics: Dasatinib; Hematologic Neoplasms; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Myeloproliferative Disorders; Protein Kinase Inhibitors; Pyrimidines; Thiazoles | 2011 |
Vosaroxin : a novel antineoplastic quinolone.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Leukemia, Myeloid, Acute; Naphthyridines; Randomized Controlled Trials as Topic; Thiazoles | 2012 |
9 trial(s) available for thiazoles and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Phase 3 results for vosaroxin/cytarabine in the subset of patients ≥60 years old with refractory/early relapsed acute myeloid leukemia.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthyridines; Recurrence; Thiazoles | 2018 |
Dasatinib in children and adolescents with relapsed or refractory leukemia: results of the CA180-018 phase I dose-escalation study of the Innovative Therapies for Children with Cancer Consortium.
Topics: Adolescent; Antineoplastic Agents; Benzamides; Child; Child, Preschool; Dasatinib; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Headache; Humans; Imatinib Mesylate; Infant; Kaplan-Meier Estimate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Nausea; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Sample Size; Therapies, Investigational; Thiazoles; Treatment Outcome; Vomiting; Young Adult | 2013 |
Crenolanib is a potent inhibitor of FLT3 with activity against resistance-conferring point mutants.
Topics: Antineoplastic Agents; Benzimidazoles; Bone Marrow; Bone Marrow Cells; Colony-Forming Units Assay; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Piperidines; Point Mutation; Prognosis; Proto-Oncogene Proteins c-kit; Sequence Analysis, DNA; Tetrazolium Salts; Thiazoles; Time Factors | 2014 |
A phase 1b/2 study of vosaroxin in combination with cytarabine in patients with relapsed or refractory acute myeloid leukemia.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Cytarabine; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Male; Maximum Tolerated Dose; Middle Aged; Naphthyridines; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Remission Induction; Salvage Therapy; Survival Rate; Thiazoles; Young Adult | 2015 |
REVEAL-1, a phase 2 dose regimen optimization study of vosaroxin in older poor-risk patients with previously untreated acute myeloid leukaemia.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthyridines; Prognosis; Survival Analysis; Thiazoles; Treatment Outcome | 2015 |
Vosaroxin and vosaroxin plus low-dose Ara-C (LDAC) vs low-dose Ara-C alone in older patients with acute myeloid leukemia.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthyridines; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Prospective Studies; Remission Induction; Survival Rate; Thiazoles | 2015 |
Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): a randomised, controlled, double-blind, multinational, phase 3 study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Disease-Free Survival; Double-Blind Method; Female; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthyridines; Neoplasm Recurrence, Local; Remission Induction; Thiazoles; Treatment Outcome | 2015 |
Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mastocytosis.
Topics: Adult; Aged; Antineoplastic Agents; Dasatinib; Female; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Mastocytosis, Systemic; Middle Aged; Philadelphia Chromosome; Pyrimidines; Remission Induction; Thiazoles; Treatment Outcome | 2008 |
A phase Ib study of vosaroxin, an anticancer quinolone derivative, in patients with relapsed or refractory acute leukemia.
Topics: Adult; Aged; Aged, 80 and over; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthyridines; Neoplasm Recurrence, Local; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Salvage Therapy; Thiazoles; Treatment Outcome; Young Adult | 2011 |
77 other study(ies) available for thiazoles and Acute Myelogenous Leukemia
| Article | Year |
|---|---|
Synergistic Effects of PI3K and c-Myc Co-targeting in Acute Leukemia: Shedding New Light on Resistance to Selective PI3K-δ Inhibitor CAL-101.
Topics: Antineoplastic Agents; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Synergism; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myeloid, Acute; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-myc; Purines; Quinazolinones; Thiazoles; Tumor Suppressor Protein p53 | 2019 |
Antitumor immunity augments the therapeutic effects of p53 activation on acute myeloid leukemia.
Topics: Animals; B7-H1 Antigen; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Imidazoles; Immunotherapy; Inflammation; Killer Cells, Natural; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Neoplasm Transplantation; Proto-Oncogene Proteins c-mdm2; Thiazoles; Tumor Suppressor Protein p53 | 2019 |
Pt(II) and Pd(II) complexes with a thiazoline derivative ligand: Synthesis, structural characterization, antiproliferative activity and evaluation of pro-apoptotic ability in tumor cell lines HT-29 and U-937.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Cisplatin; Colonic Neoplasms; Coordination Complexes; Humans; Leukemia, Myeloid, Acute; Organometallic Compounds; Palladium; Thiazoles; Tumor Cells, Cultured | 2020 |
GSK3β suppression inhibits MCL1 protein synthesis in human acute myeloid leukemia cells.
Topics: Aniline Compounds; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Glycogen Synthase Kinase 3 beta; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; MAP Kinase Signaling System; Myeloid Cell Leukemia Sequence 1 Protein; RNA, Messenger; Sulfonamides; Thiazoles; U937 Cells; Urea | 2021 |
Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Humans; Hydrazones; Leukemia, Myeloid, Acute; Mice; Protein Conformation; Thiazoles; Xenograft Model Antitumor Assays | 2017 |
BMI1 Inhibitors Down-regulate NOTCH Signaling and Suppress Proliferation of Acute Leukemia Cells.
Topics: Apoptosis; Cell Proliferation; Gene Expression Regulation, Neoplastic; Heterocyclic Compounds, 2-Ring; Humans; Leukemia, Myeloid, Acute; Leukemia, T-Cell; Polycomb Repressive Complex 1; Receptors, Notch; RNA, Small Interfering; Signal Transduction; Thiazoles; Tumor Cells, Cultured | 2017 |
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3Kδ) inhibitor.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Drug Discovery; Female; Humans; Leukemia, Myeloid, Acute; Male; Mice, Nude; Molecular Docking Simulation; Protein Kinase Inhibitors; Pyridines; Rats, Sprague-Dawley; Thiazoles | 2018 |
TAK-733, a Selective MEK Inhibitor, Enhances Voreloxin-induced Apoptosis in Myeloid Leukemia Cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Inducing Factor; Cell Nucleus; Cell Survival; Drug Synergism; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; MAP Kinase Kinase Kinases; Microscopy, Confocal; Naphthyridines; Protein Kinase Inhibitors; Pyridones; Pyrimidinones; Reactive Oxygen Species; Thiazoles | 2018 |
Camalexin Induces Apoptosis via the ROS-ER Stress-Mitochondrial Apoptosis Pathway in AML Cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Stress; Humans; Indoles; Leukemia, Myeloid, Acute; Mice; Mice, Inbred BALB C; Mitochondria; Reactive Oxygen Species; Thiazoles; Xenograft Model Antitumor Assays | 2018 |
Acute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1.
Topics: Animals; Heterocyclic Compounds, 2-Ring; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Transgenic; Neoplasms, Experimental; Oncogene Proteins, Fusion; Polycomb Repressive Complex 1; Proto-Oncogene Proteins; Thiazoles; U937 Cells; Xenograft Model Antitumor Assays | 2019 |
Venetoclax Synergistically Enhances the Anti-leukemic Activity of Vosaroxin Against Acute Myeloid Leukemia Cells Ex Vivo.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Drug Synergism; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Naphthyridines; Neoplasm Recurrence, Local; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thiazoles; Tumor Cells, Cultured; Young Adult | 2019 |
SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Proliferation; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Leukemia, Myeloid, Acute; Male; Mechanistic Target of Rapamycin Complex 1; Mechanistic Target of Rapamycin Complex 2; Multiprotein Complexes; Oxazoles; Phosphorylation; Phosphorylcholine; Proto-Oncogene Proteins c-akt; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Tumor Cells, Cultured | 2013 |
Vosaroxin: a new valuable tool with the potential to replace anthracyclines in the treatment of AML?
Topics: Anthracyclines; Antineoplastic Agents; Humans; Leukemia, Myeloid, Acute; Naphthyridines; Thiazoles; Topoisomerase II Inhibitors | 2013 |
MEK/ERK dependent activation of STAT1 mediates dasatinib-induced differentiation of acute myeloid leukemia.
Topics: Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Dasatinib; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Knockdown Techniques; Humans; Leukemia, Myeloid, Acute; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Phosphorylation; Protein Kinase Inhibitors; Pyrimidines; STAT1 Transcription Factor; Thiazoles | 2013 |
The Src and c-Kit kinase inhibitor dasatinib enhances p53-mediated targeting of human acute myeloid leukemia stem cells by chemotherapeutic agents.
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Dasatinib; Daunorubicin; Female; Humans; Leukemia, Myeloid, Acute; Male; Mice; Mice, Inbred C57BL; Mice, SCID; Middle Aged; Neoplastic Stem Cells; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; RNA Interference; src-Family Kinases; Thiazoles; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays; Young Adult | 2013 |
Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression.
Topics: Antineoplastic Agents; Apoptosis; Cell Proliferation; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Dasatinib; Drug Resistance, Neoplasm; Gene Expression Profiling; Humans; Leukemia, Myeloid, Acute; Mutation; Proto-Oncogene Proteins c-kit; Pyrimidines; Thiazoles; Translocation, Genetic | 2014 |
[Detection of BCR-ABL1 chimeric gene-positive neutrophils in a patient with mixed phenotype acute leukemia].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Dasatinib; Diagnosis, Differential; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Middle Aged; Neutrophils; Phenotype; Piperazines; Pyrimidines; Thiazoles | 2013 |
Proliferation and survival signaling from both Jak2-V617F and Lyn involving GSK3 and mTOR/p70S6K/4EBP1 in PVTL-1 cell line newly established from acute myeloid leukemia transformed from polycythemia vera.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Bone Marrow; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Dasatinib; DNA Mutational Analysis; Female; Glycogen Synthase Kinase 3; Humans; Janus Kinase 2; Karyotype; Leukemia, Myeloid, Acute; Middle Aged; Mutation; Phosphoproteins; Phosphorylation; Polycythemia Vera; Protein Kinase Inhibitors; Pyrimidines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; src-Family Kinases; Thiazoles | 2014 |
Autophagy contributes to dasatinib-induced myeloid differentiation of human acute myeloid leukemia cells.
Topics: Androstadienes; Autophagy; Cell Differentiation; Cell Line, Tumor; Chloroquine; Chromones; Dasatinib; DNA Primers; Humans; Leukemia, Myeloid, Acute; Morpholines; Polymerase Chain Reaction; Protein Kinase Inhibitors; Pyrimidines; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Thiazoles; Up-Regulation; Wortmannin | 2014 |
Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation.
Topics: Aniline Compounds; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Myeloid, Acute; MCF-7 Cells; Models, Molecular; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purines; Pyrimidines; Structure-Activity Relationship; Thiazoles | 2014 |
Curcumin induces apoptosis via simultaneously targeting AKT/mTOR and RAF/MEK/ERK survival signaling pathways in human leukemia THP-1 cells.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Coloring Agents; Curcumin; Enzyme Activation; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Humans; Leukemia, Myeloid, Acute; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Oncogene Protein v-akt; raf Kinases; Tetrazolium Salts; Thiazoles; TOR Serine-Threonine Kinases | 2014 |
Dasatinib accelerates valproic acid-induced acute myeloid leukemia cell death by regulation of differentiation capacity.
Topics: Aged; Anticonvulsants; Cell Death; Cell Differentiation; Cell Line, Tumor; Dasatinib; Drug Synergism; Female; G1 Phase Cell Cycle Checkpoints; Humans; Leukemia, Myeloid, Acute; Middle Aged; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles; Valproic Acid | 2014 |
Inhibition of c-Myc overcomes cytotoxic drug resistance in acute myeloid leukemia cells by promoting differentiation.
Topics: Antineoplastic Agents; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Cell Proliferation; Drug Resistance, Neoplasm; Gene Expression; Humans; K562 Cells; Leukemia, Myeloid, Acute; Proto-Oncogene Proteins c-myc; Thiazoles; Tretinoin | 2014 |
Inhibition of c-Kit by tyrosine kinase inhibitors.
Topics: Aminopyridines; Antineoplastic Agents; Benzothiazoles; Biomarkers; Bone Marrow; Cell Line, Tumor; Clinical Trials as Topic; Dasatinib; fms-Like Tyrosine Kinase 3; Gene Expression; Hair; Hematopoietic Stem Cells; Humans; Indazoles; Leukemia, Myeloid, Acute; Niacinamide; Phenylurea Compounds; Pigmentation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Pyrroles; Sorafenib; Sulfonamides; Thiazoles | 2015 |
Targeting BAG-1: a novel strategy to increase drug efficacy in acute myeloid leukemia.
Topics: Antineoplastic Agents; Benzothiazoles; Child; Child, Preschool; DNA-Binding Proteins; Drug Delivery Systems; Drug Therapy, Combination; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Infant; Leukemia, Myeloid, Acute; Thiazoles; Transcription Factors | 2015 |
Essential role of PU.1 in maintenance of mixed lineage leukemia-associated leukemic stem cells.
Topics: Animals; Carcinogenesis; Gene Expression Regulation, Leukemic; Genes, Homeobox; Histone-Lysine N-Methyltransferase; Leukemia, Myeloid, Acute; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myeloid-Lymphoid Leukemia Protein; Neoplastic Stem Cells; Phenylurea Compounds; Prognosis; Proto-Oncogene Proteins; Receptor, Macrophage Colony-Stimulating Factor; Recombinant Fusion Proteins; Signal Transduction; Tacrolimus; Thiazoles; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Up-Regulation | 2015 |
Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells.
Topics: Cell Cycle Checkpoints; Cell Line, Tumor; Chromatin Assembly and Disassembly; Culture Media, Serum-Free; Humans; Hydroxyurea; Leukemia, Myeloid, Acute; Proteomics; Quinolines; Signal Transduction; Thiazoles | 2015 |
Dual targeting of acute myeloid leukemia progenitors by catalytic mTOR inhibition and blockade of the p110α subunit of PI3 kinase.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Class I Phosphatidylinositol 3-Kinases; Enzyme Inhibitors; Humans; Imidazoles; Leukemia, Myeloid, Acute; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction; Thiazoles; TOR Serine-Threonine Kinases; Triazines; U937 Cells | 2015 |
Vosaroxin in acute myeloid leukaemia.
Topics: Cytarabine; Female; Humans; Leukemia, Myeloid, Acute; Male; Naphthyridines; Neoplasm Recurrence, Local; Thiazoles | 2015 |
Preclinical activity of the novel B-cell-specific Moloney murine leukemia virus integration site 1 inhibitor PTC-209 in acute myeloid leukemia: Implications for leukemia therapy.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle; Cell Line, Tumor; Flow Cytometry; Heterocyclic Compounds, 2-Ring; Humans; Kaplan-Meier Estimate; Leukemia, Myeloid, Acute; Polycomb Repressive Complex 1; Prognosis; Real-Time Polymerase Chain Reaction; RNA, Small Interfering; Thiazoles; Transfection | 2015 |
Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state.
Topics: Adenylyl Imidodiphosphate; Animals; Apoenzymes; B-Lymphocytes; Catalytic Domain; Crystallography, X-Ray; Dasatinib; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Mice; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrimidines; src-Family Kinases; Thiazoles | 2009 |
Chemotherapy and dasatinib induce long-term hematologic and molecular remission in systemic mastocytosis with acute myeloid leukemia with KIT D816V.
Topics: Antineoplastic Agents; Blotting, Western; Dasatinib; DNA Primers; DNA Probes; Electrophoresis, Polyacrylamide Gel; Humans; Leukemia, Myeloid, Acute; Male; Mastocytosis, Systemic; Middle Aged; Pyrimidines; Remission Induction; Thiazoles | 2009 |
PPARdelta is a ligand-dependent negative regulator of vitamin D3-induced monocyte differentiation.
Topics: Antigens, CD34; Antigens, Differentiation; Arachidonic Acid; Cell Differentiation; Cell Line; Cholecalciferol; Computational Biology; Databases, Factual; Epoprostenol; Gene Expression Profiling; Hematopoiesis; Humans; Leukemia, Myeloid, Acute; Ligands; Monocytes; PPAR delta; Thiazoles; Up-Regulation | 2009 |
Emergence of abnormal clone with monsomy 7 in Philadelphia negative cells of CML patients treated with tyrosine kinase inhibitors.
Topics: Benzamides; Chromosomes, Human, Pair 7; Clone Cells; Dasatinib; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Middle Aged; Monosomy; Myelodysplastic Syndromes; Piperazines; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Young Adult | 2009 |
Selective killing of leukemia and lymphoma cells ectopically expressing hCGbeta by a conjugate of curcumin with an antibody against hCGbeta subunit.
Topics: Aged; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Separation; Chorionic Gonadotropin, beta Subunit, Human; Curcumin; Drug Design; Female; Humans; Leukemia; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Lymphoma; Male; Middle Aged; Sialic Acid Binding Ig-like Lectin 3; Tetrazolium Salts; Thiazoles; U937 Cells | 2009 |
Existing and emerging therapeutic options for the treatment of acute myeloid leukemia.
Topics: Adenine; Adenine Nucleotides; Aminoglycosides; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Arabinonucleosides; Carbazoles; Clofarabine; Cytarabine; Dasatinib; Daunorubicin; fms-Like Tyrosine Kinase 3; Furans; Gemtuzumab; Humans; Leukemia, Myeloid, Acute; Naphthalimides; Organophosphonates; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Sesquiterpenes; Staurosporine; Stem Cell Transplantation; Thiazoles; Tretinoin | 2008 |
Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia.
Topics: Adaptor Proteins, Signal Transducing; Antibiotics, Antineoplastic; Apoptosis; Cell Cycle Proteins; Cell Proliferation; Cells, Cultured; Drug Evaluation, Preclinical; Drug Resistance; Everolimus; Hematopoiesis; Humans; Hydrazones; Leukemia, Myeloid, Acute; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Neoplastic Stem Cells; Nitro Compounds; Phosphoproteins; Phosphorylation; Protein Biosynthesis; Protein Synthesis Inhibitors; Proteins; Sirolimus; Thiazoles; TOR Serine-Threonine Kinases; Transcription Factors | 2009 |
The anti-cancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cells.
Topics: Animals; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Isoflavones; Leukemia, Myeloid, Acute; Mice; Oxidation-Reduction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spleen; T-Lymphocytes; Tetrazolium Salts; Thiazoles; Umbilical Veins | 2009 |
Dasatinib promotes ATRA-induced differentiation of AML cells.
Topics: Cell Differentiation; Dasatinib; Drug Synergism; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Tretinoin | 2010 |
A diphtheria toxin interleukin-3 fusion protein synergizes with tyrosine kinase inhibitors in killing leukemic progenitors from BCR/ABL positive acute leukemia.
Topics: Adult; Aged; Benzamides; Blotting, Western; Cell Cycle; Cell Proliferation; Cells, Cultured; Dasatinib; Diphtheria Toxin; Drug Synergism; Female; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Interleukin-3; Interleukin-3 Receptor alpha Subunit; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplastic Stem Cells; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Pyrimidines; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles | 2010 |
Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells.
Topics: Chromosomes, Human, Pair 7; Dasatinib; Female; Genes, ras; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Middle Aged; Monosomy; Mutation; Myelodysplastic Syndromes; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Prognosis; Protein Kinase Inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Pyrimidines; ras Proteins; Thiazoles | 2010 |
Robust in vivo differentiation of t(8;21)-positive acute myeloid leukemia blasts to neutrophilic granulocytes induced by treatment with dasatinib.
Topics: Blast Crisis; Cell Differentiation; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Dasatinib; Flow Cytometry; Granulocytes; Humans; In Situ Hybridization, Fluorescence; Leukemia, Myeloid, Acute; Male; Middle Aged; Neutrophils; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Survival Rate; Thiazoles; Translocation, Genetic; Treatment Outcome | 2010 |
The topoisomerase II inhibitor voreloxin causes cell cycle arrest and apoptosis in myeloid leukemia cells and acts in synergy with cytarabine.
Topics: Apoptosis; Cell Culture Techniques; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytarabine; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Synergism; Female; Gene Deletion; Genes, p53; Humans; Lethal Dose 50; Leukemia, Myeloid, Acute; Male; Middle Aged; Myeloid Cells; Naphthyridines; Thiazoles; Topoisomerase II Inhibitors | 2011 |
Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation.
Topics: Cell Differentiation; Cell Division; Cyclic AMP; Drug Design; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Multidrug Resistance-Associated Proteins; Phosphodiesterase 4 Inhibitors; Probenecid; RNA, Small Interfering; Rolipram; Signal Transduction; Thiazoles; U937 Cells | 2011 |
The cyclin-dependent kinase inhibitor SNS-032 has single agent activity in AML cells and is highly synergistic with cytarabine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinases; Cytarabine; Drug Synergism; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Oxazoles; Phosphorylation; Thiazoles | 2011 |
Role of Pten in leukemia stem cells.
Topics: Animals; Benzamides; Dasatinib; Drug Resistance, Neoplasm; Genes, Tumor Suppressor; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Mice; Neoplastic Stem Cells; Piperazines; PTEN Phosphohydrolase; Pyrimidines; Signal Transduction; Thiazoles | 2010 |
Norovirus gastroenteritis successfully treated with nitazoxanide.
Topics: Adult; Anti-Infective Agents; Caliciviridae Infections; Diagnosis, Differential; Feces; Gastroenteritis; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Immunosuppression Therapy; Leukemia, Myeloid, Acute; Male; Nitro Compounds; Norovirus; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles | 2011 |
Reversible resistance induced by FLT3 inhibition: a novel resistance mechanism in mutant FLT3-expressing cells.
Topics: Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Enzyme Stability; fms-Like Tyrosine Kinase 3; Gene Expression Regulation, Neoplastic; Half-Life; Humans; Leukemia, Myeloid, Acute; Mutation; Phosphorylation; Piperazines; Protein Kinase Inhibitors; RNA, Messenger; Signal Transduction; Staurosporine; Thiazoles; Tyrosine; Up-Regulation | 2011 |
CPTH6, a thiazole derivative, induces histone hypoacetylation and apoptosis in human leukemia cells.
Topics: Acetylation; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Survival; Histones; Humans; Leukemia, Myeloid, Acute; Mice; Neuroblastoma; p300-CBP Transcription Factors; Protein Processing, Post-Translational; Thiazoles; Tubulin | 2012 |
Does therapy-related AML have a poor prognosis, independent of the cytogenetic/molecular determinants?
Topics: Adenine; Anthracyclines; Antineoplastic Agents; Biomarkers, Tumor; Cytarabine; Cytogenetics; Female; Germany; Humans; Leukemia, Myeloid, Acute; Middle Aged; Myelodysplastic Syndromes; Naphthalimides; Naphthyridines; Organophosphonates; Prognosis; Remission Induction; Retrospective Studies; Survival Rate; Thiazoles | 2011 |
Characteristics of, and risk factors for, infections in patients with cancer treated with dasatinib and a brief review of other complications.
Topics: Adrenal Cortex Hormones; Adult; Aged; Cytomegalovirus Infections; Dasatinib; Databases, Factual; Female; Humans; Infections; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pyrimidines; Research Design; Risk Factors; Thiazoles; Treatment Outcome | 2012 |
MCL1 down-regulation plays a critical role in mediating the higher anti-leukaemic activity of the multi-kinase inhibitor Sorafenib with respect to Dasatinib.
Topics: Antineoplastic Agents; Benzenesulfonates; Cell Line, Tumor; Dasatinib; Down-Regulation; Humans; Leukemia, Myeloid, Acute; Myeloid Cell Leukemia Sequence 1 Protein; Niacinamide; Phenylurea Compounds; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Pyridines; Pyrimidines; Sorafenib; Thiazoles | 2012 |
Rac2-MRC-cIII-generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors.
Topics: Animals; Catalase; Disease Progression; DNA Damage; DNA, Neoplasm; Electron Transport; Electron Transport Complex III; Fusion Proteins, bcr-abl; Genomic Instability; Humans; Leukemia, Myeloid, Acute; Leukemia, Myeloid, Chronic-Phase; Membrane Potential, Mitochondrial; Methacrylates; Mice; Neoplasm Proteins; Neoplastic Stem Cells; Polycythemia Vera; rac GTP-Binding Proteins; RAC2 GTP-Binding Protein; Reactive Oxygen Species; Recombinant Fusion Proteins; Superoxide Dismutase; Thiazoles | 2012 |
Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dasatinib; Drug Resistance, Neoplasm; fms-Like Tyrosine Kinase 3; Humans; Janus Kinases; Leukemia, Myeloid, Acute; Mice; Mutation; Protein Kinase Inhibitors; Pyrimidines; STAT5 Transcription Factor; Staurosporine; Stromal Cells; Thiazoles | 2012 |
[Treatment with a tyrosine-kinase inhibitor of for c-KIT mutation and AML1-ETO double positive refractory acute myeloid leukemia].
Topics: Adolescent; Benzamides; Core Binding Factor Alpha 2 Subunit; Dasatinib; Fatal Outcome; Humans; Imatinib Mesylate; Leukemia, Myeloid, Acute; Male; Mutation; Palliative Care; Piperazines; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Pyrimidines; RUNX1 Translocation Partner 1 Protein; Thiazoles; Transcription Factors | 2012 |
Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation.
Topics: Apoptosis; Caspases; Cell Line, Tumor; Cell Proliferation; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 8; Dasatinib; Enzyme Activation; Humans; K562 Cells; Leukemia, Myeloid, Acute; Mutation; Phosphorylation; Protein Isoforms; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-kit; Pyrimidines; src-Family Kinases; Thiazoles; Translocation, Genetic | 2013 |
Combination of guanine arabinoside and Bcl-2 inhibitor YC137 overcomes the cytarabine resistance in HL-60 leukemia cell line.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arabinonucleosides; Cytarabine; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Proto-Oncogene Proteins c-bcl-2; Thiazoles | 2013 |
Cross-resistance to five glucocorticoids in childhood acute lymphoblastic and non-lymphoblastic leukemia samples tested by the MTT assay: preliminary report.
Topics: Adolescent; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Glucocorticoids; Humans; Infant; Leukemia, Myeloid, Acute; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles | 2002 |
The influence of intracellular idarubicin and daunorubicin levels on drug cytotoxicity in childhood acute leukemia.
Topics: Adolescent; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child; Child, Preschool; Daunorubicin; Flow Cytometry; Humans; Idarubicin; Infant; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles | 2002 |
Ex vivo drug resistance profile in childhood acute myelogenous leukemia: no drug is more effective in comparison to acute lymphoblastic leukemia.
Topics: Carboplatin; Cell Survival; Child; Cisplatin; Coloring Agents; Drug Resistance, Neoplasm; Humans; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Tetrazolium Salts; Thiazoles; Time Factors; Treatment Outcome; Tumor Cells, Cultured | 2002 |
Establishment of a human preadipose cell line, HPB-AML-I: refractory to PPARgamma-mediated adipogenic stimulation.
Topics: Adipocytes; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Line; Chromans; Flow Cytometry; Fluorescent Antibody Technique; Humans; Hydrocortisone; Immunohistochemistry; Inclusion Bodies; Indomethacin; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Microscopy, Electron; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors; Troglitazone | 2003 |
Identification of novel inhibitors of BCR-ABL tyrosine kinase via virtual screening.
Topics: Binding Sites; Computer Simulation; Databases, Genetic; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; K562 Cells; Leukemia, Myeloid, Acute; Models, Molecular; Molecular Conformation; Protein-Tyrosine Kinases; Tetrazolium Salts; Thiazoles | 2003 |
Impact of the cyclooxygenase system on doxorubicin-induced functional multidrug resistance 1 overexpression and doxorubicin sensitivity in acute myeloid leukemic HL-60 cells.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Gene Expression; HL-60 Cells; Humans; Leukemia, Myeloid, Acute; Meloxicam; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Rhodamine 123; Thiazines; Thiazoles | 2005 |
Determination of caspase-3 activation fails to predict chemosensitivity in primary acute myeloid leukemia blasts.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Bone Marrow Cells; Caspase 3; Caspases; Cell Death; Cell Line, Tumor; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation; Female; Humans; Kinetics; Leukemia, Myeloid, Acute; Male; Middle Aged; Spectrometry, Fluorescence; Tetrazolium Salts; Thiazoles | 2005 |
Ex vivo activity of thalidomide in childhood acute leukemia.
Topics: Angiogenesis Inhibitors; Cell Cycle; Child; Child, Preschool; Cytarabine; Female; Humans; Immunophenotyping; Infant; Leukemia, Myeloid, Acute; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Tetrazolium Salts; Thalidomide; Thiazoles | 2006 |
Nitazoxanide or CD3+/CD4+ lymphocytes for recovery from severe Cryptosporidium infection after allogeneic bone marrow transplant?
Topics: Animals; Antigens, CD; Antiparasitic Agents; Biopsy; CD3 Complex; CD4-Positive T-Lymphocytes; Child; Colon; Cryptosporidiosis; Cryptosporidium; Humans; Leukemia, Myeloid, Acute; Lymphocyte Transfusion; Male; Nitro Compounds; Stem Cell Transplantation; Thiazoles; Transplantation, Homologous | 2007 |
Relationship between in vitro chemosensitivity assessed with MTT assay and clinical outcomes in 103 patients with acute leukemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Child; Child, Preschool; Coloring Agents; Cytarabine; Daunorubicin; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; Humans; Infant; Leukemia, Biphenotypic, Acute; Leukemia, Myeloid, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles; Treatment Outcome | 2007 |
Maturation of human peripheral blood leukemic cells in short-term culture.
Topics: Cell Count; Cell Differentiation; Cells, Cultured; Dimethyl Sulfoxide; Humans; Leukemia, Myeloid, Acute; Macrophages; Neutrophils; Prostaglandins A; Thiazoles; Thiazolidines; Time Factors | 1981 |
Expression of apoptosis-related oncoproteins and modulation of apoptosis by caffeine in human leukemic cells.
Topics: Apoptosis; Caffeine; Carboplatin; Cluster Analysis; Coloring Agents; Daunorubicin; Drug Resistance, Neoplasm; Flow Cytometry; G2 Phase; Gamma Rays; Gene Expression Regulation, Leukemic; Glutathione; GTP-Binding Proteins; HL-60 Cells; Humans; Immunohistochemistry; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Lymphoma, Non-Hodgkin; Multivariate Analysis; Oncogene Proteins v-fos; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; ras Proteins; S Phase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1995 |
Enhanced chemosensitivity in acute myeloid leukemia by hematopoietic growth factors: a comparison of the MTT assay with a clonogenic assay.
Topics: Adult; Aged; Antineoplastic Agents; Bromodeoxyuridine; Clone Cells; Colorimetry; Drug Synergism; Female; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Humans; Interleukin-3; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemic Infiltration; Male; Middle Aged; Stimulation, Chemical; Tetrazolium Salts; Thiazoles | 1993 |
Prediction of chemotherapy response in human leukemia using in vitro chemosensitivity test.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Coloring Agents; Cytarabine; Daunorubicin; Drug Screening Assays, Antitumor; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Tetrazolium Salts; Thiazoles | 1993 |
Down-regulation of catalase gene expression in the doxorubicin-resistant AML subline AML-2/DX100.
Topics: Antineoplastic Agents; Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Catalase; Coloring Agents; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drug Resistance, Neoplasm; Glucosephosphate Dehydrogenase; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Herbicides; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Leukemia, Myeloid, Acute; Oxidants; Paraquat; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Superoxide Dismutase; tert-Butylhydroperoxide; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2001 |
Resistance circumvention strategies tested in clinical leukaemia specimens using the MTT colorimetric assay.
Topics: Antineoplastic Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vincristine | 1992 |
Expression of the multidrug transporter P-glycoprotein and in vitro chemosensitivity: correlation with in vivo response to chemotherapy in acute myeloid leukemia.
Topics: Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Child; Colorimetry; Drug Resistance; Female; Humans; Immunohistochemistry; Leukemia, Myeloid, Acute; Male; Membrane Glycoproteins; Middle Aged; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1991 |
Utility of flow cytometric reticulocyte quantification as a predictor of engraftment in autologous bone marrow transplantation.
Topics: Adolescent; Adult; Benzothiazoles; Bone Marrow Transplantation; Erythrocyte Count; Female; Flow Cytometry; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Prognosis; Quinolines; Reticulocytes; Staining and Labeling; Thiazoles | 1989 |
Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukaemia.
Topics: Colorimetry; Coloring Agents; Drug Screening Assays, Antitumor; Humans; Leukemia, Myeloid, Acute; Tetrazolium Salts; Thiazoles | 1989 |
Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.
Topics: Bryostatins; Cell Differentiation; Cell Line; Diglycerides; Diterpenes; Drug Resistance; Enzyme Activation; Humans; Lactones; Leukemia, Myeloid, Acute; Macrolides; Phosphorylation; Protein Kinase C; Proteins; Pyrimidinones; Terpenes; Tetradecanoylphorbol Acetate; Thiazoles | 1987 |