Page last updated: 2024-08-21

thiazoles and Acute Lymphoid Leukemia

thiazoles has been researched along with Acute Lymphoid Leukemia in 140 studies

Research

Studies (140)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (0.71)	18.7374
1990's	10 (7.14)	18.2507
2000's	58 (41.43)	29.6817
2010's	70 (50.00)	24.3611
2020's	1 (0.71)	2.80

Authors

Authors	Studies
Boldrin, E; Debatin, KM; Fischer-Posovszky, P; Kestler, HA; Kraus, JM; Meyer, LH; Meyer, M; Schlichtig, F; Zinngrebe, J	1
Chen, Y; Hu, B; Lv, M; Mu, Q; Ouyang, G; Shi, C; Wang, Y; Wu, W; Yang, S; Zhang, Y; Zhu, H	1
Kim, DH; Kim, JC; Kim, SH; Kwan, J; Park, KS; Shin, SH; Woo, SI; Yi, HG	1
Agrawal, S; Baruchel, A; Beverloo, BB; den Boer, ML; Dworzak, M; Kearns, PR; Lancaster, DL; Lehrnbecher, T; Manos, G; Mechinaud, F; Pieters, R; Reinhardt, D; Rizzari, C; Rosenberg, J; Strauss, L; van der Velden, VH; Zwaan, CM	1
Asami, K; Chansu, S; Imamura, M; Ogawa, A; Watanabe, A	1
Ge, Z; Hong, M; Li, JY; Pan, LQ; Qian, SX; Song, P; Tian, T; Yu, H; Zhang, SJ; Zhu, Y	1
Burger, JA; Challagundla, P; Champlin, RE; Cortes, JE; Estrov, Z; Faderl, S; Ferrajoli, A; Garris, R; Huang, X; Jorgensen, JL; Kantarjian, HM; Kebriaei, P; Luthra, R; O'Brien, S; Ravandi, F; Thomas, DA; Wang, SA; Wen, S	1
Jozwiak, Z; Laroche-Clary, A; Marszalek, I; Matusiak, A; Robert, J; Szwed, M	1
Busca, A; Daraio, F; Fava, C; Gottardi, E; Rege-Cambrin, G; Saglio, G	1
Li, JY; Qiu, ZY; Xu, W	1
Bhojwani, D; Campana, D; Cheng, C; Choi, JK; Coustan-Smith, E; Howard, SC; Inaba, H; Jacobsen, J; Jeha, S; Metzger, ML; Pei, D; Pui, CH; Raimondi, S; Ribeiro, RC; Rubnitz, JE; Sandlund, JT; Shurtleff, SA	1
Hatta, Y	1
McElligott, F; O'Marcaigh, A; O'Rafferty, C; Smith, O; Storey, L	1
Benjamini, O; Burger, J; Champlin, R; Cortes, J; Dumlao, TL; Faderl, S; Garcia-Manero, G; Garris, R; Jabbour, E; Jorgensen, J; Kantarjian, H; Kebriaei, P; Luthra, R; O'Brien, S; Ravandi, F; Thomas, D	1
De Vita, S; Ebert, BL; Garcia, M; Gavillet, M; Gerbaulet, A; Levine, RL; Mullally, A; Roers, A; Schneider, RK; Williams, DA; Wood, J	1
Chang, H; Chou, WC; Hung, YS	1
Braley, J; Branford, S; Dang, P; Heatley, SL; Hughes, TP; Moore, S; Moulton, DJ; Mullighan, CG; Nievergall, E; White, DL; Yeung, DT	1
Alexandrova, AN; Armijo, AL; Czernin, J; Gipson, RM; Jung, ME; Lavie, A; Le, T; Li, Z; Nguyen, HA; Nomme, J; Poddar, S; Radu, CG; Santarsiero, BD; Smith, T; Wang, J	1
Akimoto, S; Goto, H; Ishibashi, T; Kiyokawa, N; Kobayashi, K; Kojima, Y; Matsumoto, K; Matsuoka, M; Mitsui, K; Miyagawa, N; Nagai, J; Ohara, A; Okada, Y; Okita, H; Ootsubo, K; Sultana, S; Takahashi, H; Ueno, H	1
Appelmann, I; Carbonetti, G; Chen, C; de Stanchina, E; Lowe, SW; Rillahan, CD; Sherr, CJ	1
Audemard, A; Bergot, E; Chantepie, S; de la Gastine, B; Gac, AC; Reman, O; Verger, H	1
Çengel, A; Özkurt, ZN; Taçoy, G; Türkoğlu, S	1
Imamura, J; Najima, Y; Ohta, S	1
Chen, XJ; Guo, Y; Liu, F; Liu, TF; Ruan, M; Wang, SC; Yang, WY; Zhang, L; Zhu, XF; Zou, Y	1
Belz, K; Fulda, S; Haß, C; Schoeneberger, H	1
Amabile, M; Arruga, F; Baccarani, M; Baruzzi, A; Berton, G; Chiaretti, S; Cilloni, D; Foà, R; Giannoulia, P; Iacobucci, I; Lonetti, A; Martinelli, G; Messa, F; Ottaviani, E; Pane, F; Paolini, S; Papayannidis, C; Perini, G; Piccaluga, PP; Poerio, A; Saglio, G; Soverini, S; Vitale, A	1
Wong, SF	1
Bergeron, A; Cony-Makhoul, P; Corm, S; Dubruille, V; Nicolini, FE; Rea, D; Rigal-Huguet, F	1
Usui, N	1
Cortes, J; Quintás-Cardama, A	1
Boschelli, F; Gambacorti-Passerini, C; Magistroni, V; Marega, M; Perini, P; Piazza, R; Redaelli, S; Rostagno, R	1
Brizard, F; Chomel, JC; Cividin, M; Guilhot, F; Méchinaud, F; Millot, F	1
Ando, K; Fujisawa, S; Iida, S; Ishizawa, KI; Jinnai, I; Miyawaki, S; Miyazaki, Y; Morishima, Y; Motoji, T; Nagai, T; Naoe, T; Ohnishi, K; Ohno, R; Okada, M; Okamoto, S; Sakamaki, H; Seriu, T; Tanimoto, M; Taniwaki, M; Tobinai, K; Uoshima, N; Usui, N; Utsunomiya, A	1
Snyder, DS	1
Borthakur, G; Cortes, J; Fava, C; Garcia-Manero, G; Jabbour, E; Jain, N; Kantarjian, HM; O'Brien, S; Ravandi, F; Rios, MB; Shan, J; Verstovsek, S	1
Arstila, TP; Dybedal, I; Ekblom, M; Epling-Burnette, PK; Guilhot, F; Hjorth-Hansen, H; Höglund, M; Kovanen, P; Laurinolli, T; Liesveld, J; Mustjoki, S; Paquette, R; Pinilla-Ibarz, J; Porkka, K; Rauhala, A; Shah, N; Simonsson, B; Sinisalo, M; Steegmann, JL; Stenke, L	1
Gruber, F; Mustjoki, S; Porkka, K	1
Isidori, A; Malagola, M; Piccaluga, P; Visani, G	1
Abruzzese, E; Apperley, JF; Bullorsky, EO; Cortes, JE; de Souza, CA; Erben, P; Heim, D; Hochhaus, A; Hughes, TP; Khoury, HJ; Kim, DW; Kim, HJ; Larson, RA; Lipton, JH; Roboz, GJ; Rosti, G; Roy, L; Sillaber, C; Stone, RM; Van Tornout, J	1
Berridge, MV; Davis, JE; Herst, PM; Neeson, P; Ritchie, DS	1
Ottmann, OG; Pfeifer, H	2
Breitenstein, A; Goede, J; Kühne, R; Marek, A; Minder, EI; Renner, C; Schanz, U	1
Abruzzese, E; Amabile, M; Baccarani, M; Castagnetti, F; Cilloni, D; Colarossi, S; de Matteis, S; Gnani, A; Gozzini, A; Gugliotta, G; Iacobucci, I; Martinelli, G; Merante, S; Orlandi, E; Palandri, F; Paolini, S; Papayannidis, C; Poerio, A; Rosti, G; Soverini, S	1
Asenova, S; Ayuk, F; Bacher, U; Brummendorf, TH; Klyuchnikov, E; Kröger, N; Ocheni, S; Osanmaz, O; Schafhausen, P; Zabelina, T; Zander, AR	1
Brunetto, AL; de Castro, CG; Gregianin, LJ; Meneses, CF	1
Arai, T; Hayasaka, K; Ito, M; Iwaba, A; Izumino, H; Kanno, M; Kawakami, T; Mitsui, T; Sendo, D; Shimokaze, T; Takahashi, N; Takeda, H	1
Amano, M; Fujii, Y; Seriu, T	1
Almqvist, A; Hernesniemi, S; Kähkönen, M; Lundán, T; Mustjoki, S; Porkka, K; Rauhala, A	1
Forman, SJ; Kogut, NM; O'Donnell, MR; Palmer, JM; Senitzer, D; Slovak, ML; Snyder, DS; Spielberger, RT; Stein, AS; Thomas, SH; Tsai, NC	1
Bendit, I; Conchon, M; de Barros Ferreira, P; Dulley, FL; Filho, UA; Llacer-Dorliac, PE; Novaes, MM; Saboya, R; Sanabani, SS; Serpa, M	1
Hamerschlak, N; Kerbauy, FR; Mac-Donald Bley do Nascimento, C; Mauro Kutner, J; Ribeiro, AA; Rodrigues, M; Santos, FP	1
Czyz, A; Komarnicki, M; Kroll, R; Lewandowski, K	1
Marin, D; Pavlů, J	1
Stock, W	1
Arbitrario, JP; Fox, JA; Hawtin, RE; Howlett, AR; Kumer, JL; Scatena, CD; Silverman, JA	1
Hochhaus, A; Lindauer, M	1
Fei, F; Groffen, J; Heisterkamp, N; Kim, YM; Müschen, M; Stoddart, S	1
Brigid Bradley-Garelik, M; Bullorsky, E; Charbonnier, A; Dombret, H; Ehninger, G; Larson, RA; Lilly, MB; Martinelli, G; Müller, MC; Ottmann, OG; Reiffers, JJ; Shah, NP; Zhu, C	1
Fullmer, A; Jabbour, E	1
Frankel, AE; Hogge, DE; Kim, HP	1
Brixey, AG; Light, RW	1
Hatsumi, N; Hoshino, T; Miyawaki, K; Miyawaki, S; Sakura, T; Tahara, K; Takada, S	1
Ahluwalia, MS; Battiwalla, M; Cohen, IL; Francis, J; McCarthy, PL; Paplham, P; Smiley, S; Spangenthal, E; Wang, E; Wetzler, M	1
Fei, F; Groffen, J; Heisterkamp, N; Stoddart, S	1
Borthakur, G; Burger, J; Champlin, R; Cortes, J; Dara, S; Faderl, S; Ferrajoli, A; Garcia-Manero, G; Garris, R; Jones, D; Jorgensen, J; Kantarjian, H; Kebriaei, P; O'Brien, S; Ravandi, F; Thomas, D; Wierda, W	1
Fielding, AK	1
Barbany, G; Engdahl, I; Hermansson, M; Höglund, M; Lundán, T; Ohm, AC; Olsson-Strömberg, U; Porkka, K; Simonsson, B	1
Ashizawa, M; Ishida, Y; Kako, S; Kanda, Y; Kikuchi, M; Kimura, S; Nakasone, H; Nishida, J; Okuda, S; Oshima, K; Sakamoto, K; Sato, M; Terasako, K; Yamazaki, R	1
Asada, T; Fujimori, Y; Fujita, K; Ikegame, K; Ogawa, H; Okada, M; Satake, A; Tamaki, H	1
Camitta, B; Prestidge, T; Schultz, KR	1
Barbaric, D; Bhadri, VA; Satharasinghe, K; Sugo, E; Trahair, TN	1
Adamson, PC; Agrawal, S; Aplenc, R; Balis, FM; Blaney, SM; Ingle, AM; Shusterman, S; Strauss, LC; Sun, J; Wright, JJ	1
Boulos, N; Calabrese, CR; Morrison, JB; Mulder, HL; Rehg, JE; Relling, MV; Sherr, CJ; Williams, RT	1
Fujisawa, S; Fujita, H; Ishigatsubo, Y; Kanamori, H; Maruta, A; Motohashi, K; Numata, A; Sakai, R; Tachibana, T; Tanaka, M; Tomita, N	1
Ravandi, F	1
Ando, K; Fujisawa, S; Iida, S; Ishizawa, K; Kobayashi, Y; Miyawaki, S; Motoji, T; Nagai, T; Ohno, R; Okada, M; Sakamaki, H; Seriu, T; Taniwaki, M; Uoshima, N; Usui, N; Yamamoto, K	1
Cortes, J; Kantarjian, H; Mathisen, MS; O'Brien, S; Ravandi, F; Thomas, D	1
Abdool, A; Bruey, JM; Yeh, CH	1
Allen, RS; Chen, T; Cripe, LD; Fox, JA; Giles, FJ; Kantarjian, HM; Karp, JE; Lancet, JE; List, AF; Michelson, GC; Ravandi, F; Ricklis, RM	1
Baccarani, M; Candoni, A; Castagnola, C; Cimino, G; De Propris, MS; Elia, L; Fazi, P; Ferrara, F; Foà, R; Fozza, C; Guarini, A; Iacobucci, I; Leoni, P; Luppi, M; Mandelli, F; Martinelli, G; Meloni, G; Nobile, F; Paoloni, F; Sica, S; Soverini, S; Vignetti, M; Vitale, A; Zuffa, E	1
Haus, O; Jarzab, B; Jarzab, M; Kowalska, M; Oczko-Wojciechowska, M; Pogorzala, M; Styczynski, J; Szczepanek, J; Tretyn, A; Wysocki, M	1
Miura, M; Niioka, T; Sawada, K; Takahashi, N	1
Giannopoulos, K; Kosior, K; Lewandowska-Grygiel, M	1
Arras, M; Atzeni, S; Caocci, G; Greco, M; La Nasa, G; Ledda, A; Littera, R; Murgia, F; Piras, E; Vacca, A	1
Chen, SH; Ho, PC; Huang, JL; Hung, IJ; Jaing, TH; Lee, WI; Shih, LY; Yang, CP	1
Barbaccia, V; Borroni, G; Brazzelli, V; Giorgiani, G; Grasso, V; Manna, G; Rivetti, N; Vassallo, C; Zecca, M	1
Kim, HS; Kwak, JY; Lee, NR; Song, EK; Yhim, HY; Yim, CY	1
Miura, M; Niioka, T; Sawada, K; Scott, SA; Takahashi, N	1
Kantarjian, H; Liu-Dumlao, T; O'Brien, S; Ravandi, F; Thomas, DA	1
Kawakami, K; Matsunaga, T; Matsuoka, A; Miura, M; Niioka, T; Sawada, K; Takahashi, N	1
Cortes, J; Santos, FP	1
Bicocca, VT; Chang, BH; Druker, BJ; Loriaux, MM; Masouleh, BK; Muschen, M; Tyner, JW	1
Eyrich, M; Langhammer, F; Schlegel, PG; Wiegering, V; Wölfl, M	1
Dolgin, E	1
Chen, HC; Hwang, WL; Teng, CL; Yu, JT	1
Balcerska, A; Balwierz, W; Chybicka, A; Debski, R; Kowalczyk, J; Matysiak, M; Rokicka-Milewska, R; Sońta-Jakimczyk, D; Styczyński, J; Wachowiak, J; Wysocki, M	1
Balcerska, A; Balwierz, W; Chybicka, A; Debski, R; Kowalczyk, J; Kurylak, A; Matysiak, M; Rokicka-Milewska, R; Sońta-Jakimczyk, D; Styczyński, J; Wachowiak, J; Wysocki, M	1
Liu, XP; Narla, RK; Uckun, FM	1
Debski, R; Juraszewska, E; Malinowska, I; Mazur, B; Ploszynska, A; Stanczak, E; Stefaniak, J; Styczynski, J; Szczepanski, T; Wysocki, M	1
Blazek, B; Hajduch, M; Janostakova, A; Kouzmina, G; Mihal, V; Noskova, V; Orel, M; Pospisilova, D; Safarova, M; Stary, J	1
Armstrong, SA; Beverloo, HB; de Lorenzo, P; den Boer, ML; Horstmann, M; Nollau, P; Pieters, R; Sallan, SE; Schneider, P; Stam, RW; Valsecchi, MG; van der Voort, E	1
Asselin, B; Buck, S; Hamre, M; Ozdemir, O; Pullen, J; Ravindranath, Y; Savaşan, S	1
Bennett, R; Dunn, SP; Feidler, KL; Gomez-Curet, I; Krueger, LJ; Perkins, RS	1
Abruzzese, E; Amadori, S; Barbato, R; Coletta, AM; De Fabritiis, P; Del Poeta, G; Francesconi, F; Fratoni, S; Patroi, IM; Santeusanio, G; Trawinska, MM; Zangrilli, D	1
Blackwood-Chirchir, MA; Bleickardt, E; Chen, TT; Cortes, J; Decillis, AP; Donato, N; Huang, F; Iyer, V; Kantarjian, H; Nicaise, C; Nicoll, J; O'Brien, S; Paquette, R; Sawyers, CL; Shah, NP; Talpaz, M	1
Druker, BJ	1
Czyzewski, K; Styczynski, J; Wysocki, M	1
Grimley, J; Jabbour, E; Kantarjian, H; Kirkpatrick, P	1
Baccarani, M; Bosi, C; Castagnetti, F; Cilloni, D; Colarossi, S; Giannoulia, P; Gnani, A; Iacobucci, I; Luatti, S; Martinelli, G; Marzocchi, G; Palandri, F; Paolini, S; Piccaluga, PP; Rondoni, M; Rosti, G; Saglio, G; Soverini, S; Testoni, N	2
Ainoon, O; Cheong, SK; Fazlina, N; Hamidah, H; Hamidah, NH; Jamal, R; Maha, A; Zarina, AL; Zulkifli, SZ	1
Apanovitch, AM; Coutre, S; Dombret, H; Gollerkeri, A; Guilhot, F; Hochhaus, A; Larson, RA; Martinelli, G; Ottmann, O; Radich, J; Rege-Cambrin, G; Simonsson, B	1
Martinelli, G; Paolini, S; Piccaluga, PP	1
Brodzik, F; Mehdi, S; Pasquale, D; Ramanarayanan, J	1
Billups, CA; Gorlick, R; Houghton, PJ; Keir, ST; Kolb, EA; Lock, RB; Maris, JM; Morton, CL; Reynolds, CP; Smith, MA; Tajbakhsh, M	1
Chiusolo, P; Farina, G; Fiorini, A; Leone, G; Reddiconto, G; Sica, S; Sorà, F	1
Thomas, X	1
Brandwein, J	1
Chi, HS; Choi, SJ; Im, HJ; Jang, S; Jun, KR; Lee, JH; Lee, KH; Moon, HN; Park, CJ; Seo, JJ	1
Steinberg, M	1
Keam, SJ	1
Booth, B; Brave, M; Bullock, J; Farrell, A; Gobburu, J; Goodman, V; Harapanhalli, R; Jiang, X; Justice, R; Kaminskas, E; Kenna, L; Men, A; Morse, D; Noory, C; Pazdur, R; Pope, S; Ramchandani, R; Saber, H; Sridhara, R; Timmer, W	1
Cobanoglu, U; Omay, SB; Ovali, E; Sonmez, M	1
Arnan, M; Brethon, B; Brito-Babapulle, F; Dombret, H; Duarte, RF; Eccersley, L; Elonen, E; Gruber, F; Hjorth-Hansen, H; Höglund, M; Klamova, H; Knutsen, H; Koskenvesa, P; Lee, FY; Lundán, T; Luo, R; Mustjoki, S; Paquette, R; Parikh, S; Porkka, K; Raffoux, E; Rimpiläinen, J; Smykla, R; Wild, R; Zwaan, CM	1
Hall, AG; Matheson, E; Maung, ZT; Proctor, SJ; Reid, MM; Taylor, PR	1
Hählen, K; Kaspers, GJ; Pieters, R; Van Wering, ER; Van Zantwijk, I; Veerman, AJ	1
Broekema, GJ; Hählen, K; Huismans, DR; Kaspers, GJ; Kazemier, KM; Loonen, AH; Pieters, R; Rottier, MA; van Zantwijk, CH; Veerman, AJ	1
Chen, LM; Huang, SH; Hwang, WS; Tseng, MT; Wang, CC	1
Hählen, K; Huismans, DR; Kaspers, GJ; Loonen, AH; Pieters, R; van Wering, ER; Veerman, AJ	1
Kaspers, GJ; Lomecky, M; Pieters, R; Popp-Snijders, C; Swinkels, LM; Van Wering, ER; Van Zantwijk, CH; Veerman, AJ	1
Jansen, G; Kaspers, GJ; Mauritz, R; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ	1
Bhattacharya, DK; Mandal, C; Sinha, D	1
Narla, RK; Perrey, DA; Scannell, MP; Uckun, FM	1
Narla, RK; Perrey, DA; Uckun, FM	1
Hählen, K; Huismans, DR; Loonen, AH; Pieters, R; van der Does-van den Berg, A; van Wering, ER; Veerman, AJ	1
Broekema, GJ; Dirven, MW; Hählen, K; Heyenbrok, MW; Huismans, DR; Loonen, AH; Pieters, R; Veerman, AJ	1
Huismans, DR; Leyva, A; Pieters, R; Veerman, AJ	1

Reviews

21 review(s) available for thiazoles and Acute Lymphoid Leukemia

Article	Year
Large granular lymphocytosis during dasatinib therapy. Cancer biology & therapy, 2014, Mar-01, Volume: 15, Issue:3 Topics: Antineoplastic Agents; Clone Cells; Colitis; Dasatinib; Familial Primary Pulmonary Hypertension; Humans; Killer Cells, Natural; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphocytosis; Pleural Effusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; T-Lymphocytes, Cytotoxic; Thiazoles; Thrombocytopenia	2014
[Acute lymphoblastic leukemia]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2014, Volume: 55, Issue:2 Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cyclophosphamide; Dasatinib; Daunorubicin; Doxorubicin; Enzyme Inhibitors; Humans; Imatinib Mesylate; Methotrexate; Middle Aged; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles; Young Adult	2014
Dasatinib dosing strategies in Philadelphia chromosome-positive leukemia. Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2009, Volume: 15, Issue:1 Topics: Clinical Trials as Topic; Dasatinib; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Neoplasm; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles	2009
[Management of acute lymphoblastic leukemia]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2008, Volume: 49, Issue:10 Topics: Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Biomarkers; Combined Modality Therapy; Dasatinib; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Molecular Diagnostic Techniques; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Remission Induction; Thiazoles	2008
New approved dasatinib regimen available for clinical use. Expert review of anticancer therapy, 2009, Volume: 9, Issue:3 Topics: Clinical Trials, Phase III as Topic; Dasatinib; Drug Resistance, Neoplasm; Humans; Leukemia, Myeloid, Chronic-Phase; Pleural Effusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Thrombocytopenia	2009
Impact of tyrosine kinase inhibitors on patient outcomes in Philadelphia chromosome-positive acute lymphoblastic leukaemia. British journal of haematology, 2009, Volume: 145, Issue:5 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Child; Combined Modality Therapy; Dasatinib; Fusion Proteins, bcr-abl; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Neoplasm, Residual; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Transplantation Conditioning; Treatment Outcome	2009
First-line treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia in adults. Current opinion in oncology, 2009, Volume: 21 Suppl 1 Topics: Adult; Antineoplastic Agents; Benzamides; Combined Modality Therapy; Dasatinib; Humans; Imatinib Mesylate; Mutation; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Stem Cell Transplantation; Thiazoles; Treatment Outcome	2009
Pharmacological properties and clinical efficacy of dasatinib hydrate (Sprycel), an anticancer drug for chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2009, Volume: 134, Issue:3 Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Dasatinib; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Pyrimidines; src-Family Kinases; Thiazoles	2009
Current treatment options for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Leukemia & lymphoma, 2010, Volume: 51, Issue:2 Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Clinical Trials as Topic; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles	2010
Dasatinib. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer, 2010, Volume: 184 Topics: Clinical Trials as Topic; Dasatinib; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Oncogene Proteins v-abl; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyrimidines; Receptor, Platelet-Derived Growth Factor alpha; src-Family Kinases; Thiazoles	2010
Pleural effusions due to dasatinib. Current opinion in pulmonary medicine, 2010, Volume: 16, Issue:4 Topics: Clinical Trials as Topic; Dasatinib; Humans; Incidence; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Pleural Effusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Risk Factors; Thiazoles	2010
Philadelphia chromosome-positive acute lymphoblastic leukemia in children: new and emerging treatment options. Expert review of hematology, 2010, Volume: 3, Issue:6 Topics: Adolescent; Antineoplastic Agents; Benzamides; Child; Dasatinib; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Risk Factors; Thiazoles; Transplantation, Homologous	2010
Managing Philadelphia chromosome-positive acute lymphoblastic leukemia: role of tyrosine kinase inhibitors. Clinical lymphoma, myeloma & leukemia, 2011, Volume: 11, Issue:2 Topics: Antineoplastic Agents; Benzamides; Dasatinib; Humans; Imatinib Mesylate; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles	2011
Role of tyrosine kinase inhibitors in the management of Philadelphia chromosome-positive acute lymphoblastic leukemia. Current hematologic malignancy reports, 2011, Volume: 6, Issue:3 Topics: Benzamides; Clinical Trials as Topic; Combined Modality Therapy; Dasatinib; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Stem Cell Transplantation; Thiazoles; Transplantation, Homologous	2011
Tyrosine kinase inhibitors in hematological malignancies. Postepy higieny i medycyny doswiadczalnej (Online), 2011, Dec-05, Volume: 65 Topics: Aniline Compounds; Antineoplastic Agents; Benzamides; Dasatinib; Hematologic Neoplasms; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Nitriles; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Pyrimidines; Quinolines; Thiazoles	2011
Philadelphia-positive acute lymphoblastic leukemia: current treatment options. Current oncology reports, 2012, Volume: 14, Issue:5 Topics: Aniline Compounds; Antineoplastic Agents; Benzamides; Dasatinib; Humans; Imatinib Mesylate; Imidazoles; Neoplasm, Residual; Nitriles; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyridazines; Pyrimidines; Quinolines; Stem Cell Transplantation; Thiazoles	2012
Dasatinib for the treatment of Philadelphia chromosome-positive leukemias. Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:16 Topics: Animals; Antineoplastic Agents; Benzamides; Dasatinib; Drug Resistance, Neoplasm; Humans; Imatinib Mesylate; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles	2012
Tyrosine kinase inhibitors for the treatment of Philadelphia chromosome-positive adult acute lymphoblastic leukemia. Cancer, 2007, Sep-15, Volume: 110, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Recurrence; Survival Analysis; Thiazoles; Treatment Outcome	2007
[Acute lymphoblastic leukemia with Philadelphia chromosome: treatment with kinase inhibitors]. Bulletin du cancer, 2007, Volume: 94, Issue:10 Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Benzamides; Benzenesulfonates; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Indoles; Niacinamide; Phenylurea Compounds; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Pyrroles; Sorafenib; Sunitinib; Thiazoles	2007
Dasatinib: a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia. Clinical therapeutics, 2007, Volume: 29, Issue:11 Topics: Adult; Aged; Aged, 80 and over; Benzamides; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Contraindications; Dasatinib; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Models, Chemical; Mutation; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-bcr; Pyrimidines; Randomized Controlled Trials as Topic; Receptors, Purinergic P2; Thiazoles	2007
Dasatinib: in chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy, 2008, Volume: 22, Issue:1 Topics: Animals; Controlled Clinical Trials as Topic; Dasatinib; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles	2008

Trials

15 trial(s) available for thiazoles and Acute Lymphoid Leukemia

Article	Year
Dasatinib in children and adolescents with relapsed or refractory leukemia: results of the CA180-018 phase I dose-escalation study of the Innovative Therapies for Children with Cancer Consortium. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Jul-01, Volume: 31, Issue:19 Topics: Adolescent; Antineoplastic Agents; Benzamides; Child; Child, Preschool; Dasatinib; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Headache; Humans; Imatinib Mesylate; Infant; Kaplan-Meier Estimate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Male; Nausea; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Sample Size; Therapies, Investigational; Thiazoles; Treatment Outcome; Vomiting; Young Adult	2013
Phase II trial of hyper CVAD and dasatinib in patients with relapsed Philadelphia chromosome positive acute lymphoblastic leukemia or blast phase chronic myeloid leukemia. American journal of hematology, 2014, Volume: 89, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dasatinib; Dexamethasone; Doxorubicin; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recurrence; Thiazoles; Vincristine; Young Adult	2014
Phase 1/2 clinical study of dasatinib in Japanese patients with chronic myeloid leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia. International journal of hematology, 2009, Volume: 89, Issue:3 Topics: Adult; Aged; Antineoplastic Agents; Asian People; Dasatinib; Fusion Proteins, bcr-abl; Humans; Leukemia, Myeloid, Chronic-Phase; Middle Aged; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Thiazoles	2009
Failure to achieve a complete hematologic response at the time of a major cytogenetic response with second-generation tyrosine kinase inhibitors is associated with a poor prognosis among patients with chronic myeloid leukemia in accelerated or blast phase Blood, 2009, May-21, Volume: 113, Issue:21 Topics: Adolescent; Adult; Aged; Benzamides; Blast Crisis; Cytogenetic Analysis; Dasatinib; Female; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Accelerated Phase; Male; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Remission Induction; Survival Analysis; Thiazoles; Treatment Failure; Young Adult	2009
Dasatinib in the treatment of chronic myeloid leukemia in accelerated phase after imatinib failure: the START a trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jul-20, Volume: 27, Issue:21 Topics: Adult; Aged; Aged, 80 and over; Benzamides; Dasatinib; Disease-Free Survival; Female; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Thiazoles; Treatment Failure; Treatment Outcome; Young Adult	2009
Dasatinib 140 mg once daily versus 70 mg twice daily in patients with Ph-positive acute lymphoblastic leukemia who failed imatinib: Results from a phase 3 study. American journal of hematology, 2010, Volume: 85, Issue:3 Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Benzamides; Dasatinib; Disease Management; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Gastrointestinal Hemorrhage; Humans; Imatinib Mesylate; Male; Middle Aged; Neoplasm Proteins; Piperazines; Pleural Effusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; RNA, Messenger; RNA, Neoplasm; Salvage Therapy; src-Family Kinases; Thiazoles; Young Adult	2010
First report of phase 2 study of dasatinib with hyper-CVAD for the frontline treatment of patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia. Blood, 2010, Sep-23, Volume: 116, Issue:12 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dasatinib; Dexamethasone; Doxorubicin; Female; Humans; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Remission Induction; Survival Analysis; Thiazoles; Vincristine; Young Adult	2010
Pediatric phase I trial and pharmacokinetic study of dasatinib: a report from the children's oncology group phase I consortium. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2011, Mar-01, Volume: 29, Issue:7 Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Dasatinib; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Hematologic Neoplasms; Hospitals, Pediatric; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Maximum Tolerated Dose; Neoplasms; Patient Selection; Pediatrics; Philadelphia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Risk Assessment; Thiazoles; Treatment Outcome; Young Adult	2011
A phase Ib study of vosaroxin, an anticancer quinolone derivative, in patients with relapsed or refractory acute leukemia. Leukemia, 2011, Volume: 25, Issue:12 Topics: Adult; Aged; Aged, 80 and over; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Naphthyridines; Neoplasm Recurrence, Local; Neoplasm Staging; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Salvage Therapy; Thiazoles; Treatment Outcome; Young Adult	2011
Dasatinib as first-line treatment for adult patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood, 2011, Dec-15, Volume: 118, Issue:25 Topics: Adult; Aged; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Dasatinib; Drug Administration Schedule; Female; Flow Cytometry; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Immunophenotyping; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Recurrence; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; Steroids; Thiazoles; Time Factors; Treatment Outcome; Young Adult	2011
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. The New England journal of medicine, 2006, Jun-15, Volume: 354, Issue:24 Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Benzamides; Dasatinib; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Genotype; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Mutation; Neutropenia; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles	2006
Resistance to dasatinib in Philadelphia-positive leukemia patients and the presence or the selection of mutations at residues 315 and 317 in the BCR-ABL kinase domain. Haematologica, 2007, Volume: 92, Issue:3 Topics: Adolescent; Adult; Aged; Amino Acid Substitution; Antineoplastic Agents; Benzamides; Codon; Dasatinib; DNA Mutational Analysis; DNA, Neoplasm; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Mutation, Missense; Neoplasm Proteins; Piperazines; Point Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Recurrence; Structure-Activity Relationship; Thiazoles	2007
Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study. Blood, 2007, Oct-01, Volume: 110, Issue:7 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzamides; Chromosome Aberrations; Cytogenetics; Dasatinib; Drug Resistance, Neoplasm; Drug Tolerance; Drug-Related Side Effects and Adverse Reactions; Female; Follow-Up Studies; Fusion Proteins, bcr-abl; Hematology; Humans; Imatinib Mesylate; Male; Middle Aged; Mutation; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Thiazoles; Time Factors	2007
Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia. Blood, 2008, Aug-15, Volume: 112, Issue:4 Topics: Adolescent; Adult; Aged; Animals; Blood-Brain Barrier; Central Nervous System Neoplasms; Child; Cytogenetic Analysis; Dasatinib; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Monitoring; Female; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Mice; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Remission Induction; Spinal Puncture; Survival Rate; Thiazoles; Treatment Outcome; Tumor Burden	2008
A colorimetric assay to evaluate the chemotherapeutic response of children with acute lymphoblastic leukemia (ALL) employing achatininH: a 9-O-acetyl sialic acid binding lectin. Leukemia research, 1999, Volume: 23, Issue:9 Topics: Acetylation; Child; Child, Preschool; Colorimetry; Coloring Agents; Evaluation Studies as Topic; Female; Humans; Lectins; Lymphoproliferative Disorders; Male; N-Acetylneuraminic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles; Treatment Outcome	1999

Other Studies

104 other study(ies) available for thiazoles and Acute Lymphoid Leukemia

Article	Year
Biomarker profile for prediction of response to SMAC mimetic monotherapy in pediatric precursor B-cell acute lymphoblastic leukemia. International journal of cancer, 2020, 06-01, Volume: 146, Issue:11 Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Azocines; Benzhydryl Compounds; Caspase Inhibitors; Cell Line, Tumor; Dipeptides; Female; Humans; Indoles; Inhibitor of Apoptosis Proteins; Mice; Mice, Inbred NOD; Mice, SCID; Mitochondrial Proteins; Oligopeptides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cells, B-Lymphoid; Receptors, Tumor Necrosis Factor, Type I; Thiazoles; Xenograft Model Antitumor Assays	2020
C‑Myc inhibitor 10058‑F4 increases the efficacy of dexamethasone on acute lymphoblastic leukaemia cells. Molecular medicine reports, 2018, Volume: 18, Issue:1 Topics: Cell Line, Tumor; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Dexamethasone; Drug Synergism; Gene Expression Regulation, Leukemic; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-myc; Thiazoles	2018
Rapid-onset pulmonary arterial hypertension in a patient with acute lymphoblastic leukemia treated with dasatinib. Herz, 2013, Volume: 38, Issue:8 Topics: Adult; Dasatinib; Familial Primary Pulmonary Hypertension; Humans; Hypertension, Pulmonary; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles	2013
Prophylactic post-transplant dasatinib administration in a pediatric patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. Pediatrics international : official journal of the Japan Pediatric Society, 2013, Volume: 55, Issue:3 Topics: Bone Marrow Purging; Child; Dasatinib; Dose-Response Relationship, Drug; Drug Administration Schedule; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Long-Term Care; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Secondary Prevention; Thiazoles	2013
[Efficacy of dasatinib in treatment of imatinib-resistant BCR/ABL positive leukemia]. Zhongguo shi yan xue ye xue za zhi, 2013, Volume: 21, Issue:3 Topics: Adult; Aged; Benzamides; Dasatinib; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Treatment Outcome; Young Adult	2013
Detection of MRD may predict the outcome of patients with Philadelphia chromosome-positive ALL treated with tyrosine kinase inhibitors plus chemotherapy. Blood, 2013, Aug-15, Volume: 122, Issue:7 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Doxorubicin; Female; Flow Cytometry; Follow-Up Studies; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Immunoglobulin Heavy Chains; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm, Residual; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Prognosis; Pyrimidines; Real-Time Polymerase Chain Reaction; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Survival Rate; Thiazoles; Vincristine; Young Adult	2013
Transferrin as a drug carrier: Cytotoxicity, cellular uptake and transport kinetics of doxorubicin transferrin conjugate in the human leukemia cells. Toxicology in vitro : an international journal published in association with BIBRA, 2014, Volume: 28, Issue:2 Topics: Algorithms; Antibiotics, Antineoplastic; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Coloring Agents; Doxorubicin; Drug Carriers; Flow Cytometry; Humans; K562 Cells; Kinetics; Leukemia; Lymphocytes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tetrazolium Salts; Thiazoles; Transferrin	2014
Second-generation tyrosine kinase inhibitors can induce complete molecular response in Ph-positive acute lymphoblastic leukemia after allogeneic stem cell transplant. Clinical lymphoma, myeloma & leukemia, 2013, Volume: 13 Suppl 2 Topics: Adolescent; Adult; Combined Modality Therapy; Dasatinib; Female; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Remission Induction; Stem Cell Transplantation; Thiazoles; Transplantation, Homologous; Young Adult	2013
Impact of tyrosine kinase inhibitors on minimal residual disease and outcome in childhood Philadelphia chromosome-positive acute lymphoblastic leukemia. Cancer, 2014, May-15, Volume: 120, Issue:10 Topics: Adolescent; Antineoplastic Agents; Benzamides; Child; Child, Preschool; Dasatinib; Drug Administration Schedule; Female; Flow Cytometry; Genes, T-Cell Receptor; Humans; Imatinib Mesylate; Induction Chemotherapy; Infant; Male; Neoplasm, Residual; Philadelphia Chromosome; Piperazines; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles; Treatment Outcome	2014
Pneumatosis intestinalis and imatinib mesylate. Annals of hematology, 2014, Volume: 93, Issue:10 Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Benzamides; Child, Preschool; Dasatinib; Daunorubicin; Dexamethasone; Drug Substitution; Female; Humans; Imatinib Mesylate; Parenteral Nutrition, Total; Piperazines; Pneumatosis Cystoides Intestinalis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Recurrence; Thiazoles; Vincristine	2014
Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis. PloS one, 2014, Volume: 9, Issue:5 Topics: Animals; Azacitidine; Blotting, Western; Bone Marrow Cells; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Dasatinib; Decitabine; Dioxygenases; Disease Models, Animal; DNA-Binding Proteins; Drug Therapy, Combination; Enzyme Inhibitors; Esophagus; Gastric Mucosa; Humans; Mast Cells; Mastocytosis, Systemic; Mice, Knockout; Mice, Transgenic; Mutation, Missense; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-kit; Pyrimidines; RNA Interference; Skin; Stomach; Thiazoles	2014
Pneumocystis jiroveci pneumonia in patients receiving dasatinib treatment. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2014, Volume: 25 Topics: Adult; Anti-Bacterial Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dasatinib; Female; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Pleural Effusion; Pneumocystis carinii; Pneumonia, Pneumocystis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Treatment Outcome	2014
Relapse of BCR-ABL1-like ALL mediated by the ABL1 kinase domain mutation T315I following initial response to dasatinib treatment. Leukemia, 2015, Volume: 29, Issue:1 Topics: Dasatinib; Fusion Proteins, bcr-abl; Humans; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein Kinases; Pyrimidines; Recurrence; Thiazoles	2015
Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. Journal of medicinal chemistry, 2014, Nov-26, Volume: 57, Issue:22 Topics: Animals; Antineoplastic Agents; Binding Sites; Chemistry, Pharmaceutical; Computer Simulation; Crystallography, X-Ray; Deoxycytidine; Deoxycytidine Kinase; Drug Design; Female; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred C57BL; Microsomes; Phosphorylation; Positron-Emission Tomography; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Stereoisomerism; Thiazoles	2014
TKI dasatinib monotherapy for a patient with Ph-like ALL bearing ATF7IP/PDGFRB translocation. Pediatric blood & cancer, 2015, Volume: 62, Issue:6 Topics: Child; Dasatinib; Humans; Male; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Receptor, Platelet-Derived Growth Factor beta; Repressor Proteins; Thiazoles; Transcription Factors; Translocation, Genetic	2015
Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL. Blood, 2015, Feb-26, Volume: 125, Issue:9 Topics: ADP-Ribosylation Factor 1; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Dasatinib; Dexamethasone; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Humans; Interleukin-7; Janus Kinases; Male; Mice; Mice, Inbred C57BL; Mutation; Neoplasm Recurrence, Local; Nitriles; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrazoles; Pyrimidines; Real-Time Polymerase Chain Reaction; Remission Induction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; STAT3 Transcription Factor; Survival Rate; Thiazoles; Tumor Cells, Cultured	2015
[Dasatinib-related pneumonia? An example of pharmacovigilance survey]. Revue des maladies respiratoires, 2015, Volume: 32, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Blast Crisis; Cyclophosphamide; Cytarabine; Dasatinib; Dexamethasone; Doxorubicin; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Middle Aged; Pharmacovigilance; Pneumonia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Recombinant Proteins; Thiazoles; Tomography, X-Ray Computed; Vincristine	2015
Dasatinib-induced pulmonary hypertension in acute lymphoblastic leukemia: case report. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir, 2015, Volume: 43, Issue:1 Topics: Antineoplastic Agents; Dasatinib; Humans; Hypertension, Pulmonary; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Thiazoles	2015
Dasatinib-induced gastric antral vascular ectasia in a patient with acute lymphoblastic leukaemia. British journal of haematology, 2015, Volume: 169, Issue:5 Topics: Antineoplastic Agents; Dasatinib; Endoscopes, Gastrointestinal; Gastric Antral Vascular Ectasia; Humans; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles	2015
[Efficacy and safety of tyrosine kinase inhibitor dasatinib plus chemotherapy in the treatment of childhood Philadelphia chromosome-positive acute lymphoblastic leukemia]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2015, Volume: 17, Issue:6 Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Dasatinib; Female; Humans; Male; Molecular Targeted Therapy; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles	2015
Sensitization of acute lymphoblastic leukemia cells for LCL161-induced cell death by targeting redox homeostasis. Biochemical pharmacology, 2016, Apr-01, Volume: 105 Topics: Antineoplastic Agents; Apoptosis; Cell Death; Cell Survival; Dose-Response Relationship, Drug; Drug Delivery Systems; Homeostasis; Humans; Jurkat Cells; Methionine; Oxidation-Reduction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reactive Oxygen Species; Sulfoxides; Thiazoles	2016
Expression of spliced oncogenic Ikaros isoforms in Philadelphia-positive acute lymphoblastic leukemia patients treated with tyrosine kinase inhibitors: implications for a new mechanism of resistance. Blood, 2008, Nov-01, Volume: 112, Issue:9 Topics: Adolescent; Adult; Aged; Alternative Splicing; Antineoplastic Agents; Base Sequence; Benzamides; Cell Line, Tumor; Dasatinib; DNA Primers; DNA, Neoplasm; Drug Resistance, Neoplasm; Genes, abl; Humans; Ikaros Transcription Factor; Imatinib Mesylate; Middle Aged; Mutation; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Isoforms; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles	2008
[Guidelines for the management of dasatinib (Sprycel)-induced side effects in chronic myelogenous leukemia and Philadelphia positive acute lymphoblastic leukemias]. Bulletin du cancer, 2008, Volume: 95, Issue:9 Topics: Antineoplastic Agents; Benzamides; Bone Marrow; Bone Marrow Diseases; Dasatinib; Drug Resistance, Neoplasm; Female; France; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Piperazines; Pleural Effusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pyrimidines; Thiazoles	2008
Dasatinib-induced restoration of donor chimerism in BCR-ABL1-positive ALL after failure of imatinib therapy and allo-SCT. Bone marrow transplantation, 2009, Volume: 43, Issue:7 Topics: Adolescent; Benzamides; Combined Modality Therapy; Dasatinib; Fatal Outcome; Genes, abl; Humans; Imatinib Mesylate; Male; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Stem Cell Transplantation; Thiazoles; Transplantation Chimera	2009
Activity of bosutinib, dasatinib, and nilotinib against 18 imatinib-resistant BCR/ABL mutants. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Jan-20, Volume: 27, Issue:3 Topics: Aniline Compounds; Antineoplastic Agents; Benzamides; Dasatinib; Drug Resistance, Neoplasm; Genes, abl; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mutation; Nitriles; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Quinolines; Thiazoles	2009
Successful second allogeneic stem cell transplantation in second remission induced by dasatinib in a child with Philadelphia chromosome positive acute lymphoblastic leukemia. Pediatric blood & cancer, 2009, Volume: 52, Issue:7 Topics: Child, Preschool; Dasatinib; Fusion Proteins, bcr-abl; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Remission Induction; Salvage Therapy; Thiazoles; Transplantation, Homologous	2009
Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy. Leukemia, 2009, Volume: 23, Issue:8 Topics: Adult; Aged; Antineoplastic Agents; Clinical Trials, Phase II as Topic; Cohort Studies; Colitis; Dasatinib; Female; Humans; Immunophenotyping; Killer Cells, Natural; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphocytosis; Male; Middle Aged; Multicenter Studies as Topic; Neoplasm Proteins; Pleurisy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; Thiazoles	2009
Efficacy of dasatinib in conjunction with alpha-interferon for the treatment of imatinib-resistant and dasatinib-resistant Ph+ acute lymphoblastic leukemia. Leukemia, 2009, Volume: 23, Issue:9 Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Dasatinib; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Interferon-alpha; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Thiazoles; Transplantation, Autologous	2009
Dasatinib: for some difficult cases of adult leukaemia. Prescrire international, 2008, Volume: 17, Issue:96 Topics: Adult; Clinical Trials as Topic; Drug Approval; Europe; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Orphan Drug Production; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles	2008
The anti-cancer drug, phenoxodiol, kills primary myeloid and lymphoid leukemic blasts and rapidly proliferating T cells. Haematologica, 2009, Volume: 94, Issue:7 Topics: Animals; Cell Line, Tumor; Cell Membrane; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Isoflavones; Leukemia, Myeloid, Acute; Mice; Oxidation-Reduction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Spleen; T-Lymphocytes; Tetrazolium Salts; Thiazoles; Umbilical Veins	2009
Abdominal pain in a patient with acute lymphoblastic leukaemia. Annals of hematology, 2010, Volume: 89, Issue:2 Topics: Abdominal Pain; Dasatinib; Humans; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles	2010
Philadelphia-positive patients who already harbor imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second- or third-line tyrosine kinase inhibitors. Blood, 2009, Sep-03, Volume: 114, Issue:10 Topics: Adolescent; Adult; Aged; Benzamides; Dasatinib; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Mutation; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Recurrence; Thiazoles	2009
Second-generation tyrosine kinase inhibitors in the post-transplant period in patients with chronic myeloid leukemia or Philadelphia-positive acute lymphoblastic leukemia. Acta haematologica, 2009, Volume: 122, Issue:1 Topics: Aged; Aniline Compounds; Benzamides; Dasatinib; Female; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Nitriles; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Quinolines; Stem Cell Transplantation; Thiazoles	2009
Dasatinib after allogeneic stem cell transplantation in a child with Philadelphia chromosome positive acute lymphoblastic leukemia. Pediatric blood & cancer, 2009, Volume: 53, Issue:6 Topics: Child, Preschool; Dasatinib; Hematopoietic Stem Cell Transplantation; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Thiazoles; Transplantation, Homologous; Treatment Outcome	2009
Severe hemorrhagic colitis caused by dasatinib in Philadelphia chromosome-positive acute lymphoblastic leukemia. Pediatric hematology and oncology, 2009, Volume: 26, Issue:6 Topics: Bone Marrow Transplantation; Child; Colitis; Colonoscopy; Combined Modality Therapy; Dasatinib; Female; Gastrointestinal Hemorrhage; Humans; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Pyrimidines; Thiazoles	2009
A novel dasatinib-sensitive RCSD1-ABL1 fusion transcript in chemotherapy-refractory adult pre-B lymphoblastic leukemia with t(1;9)(q24;q34). Haematologica, 2009, Volume: 94, Issue:10 Topics: Adult; Amino Acid Sequence; Dasatinib; Gene Fusion; Genes, abl; Humans; Intracellular Signaling Peptides and Proteins; Male; Molecular Sequence Data; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cells, B-Lymphoid; Pyrimidines; Thiazoles; Translocation, Genetic	2009
Reduced-intensity conditioning followed by peripheral blood stem cell transplantation for adult patients with high-risk acute lymphoblastic leukemia. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009, Volume: 15, Issue:11 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Combined Modality Therapy; Dasatinib; Disease-Free Survival; Drug Administration Schedule; Female; Follow-Up Studies; Graft Survival; Graft vs Host Disease; Humans; Imatinib Mesylate; Male; Melphalan; Middle Aged; Myeloablative Agonists; Neoplasms, Second Primary; Peripheral Blood Stem Cell Transplantation; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Reoperation; Retrospective Studies; Risk; Thiazoles; Transplantation Conditioning; Transplantation, Homologous; Vidarabine; Young Adult	2009
Achievement of complete donor-type chimerism and remission with dasatinib in Philadelphia chromosome-positive ALL relapsing after allogeneic transplantation. Bone marrow transplantation, 2010, Volume: 45, Issue:6 Topics: Adult; Dasatinib; Hematopoietic Stem Cell Transplantation; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Remission Induction; Salvage Therapy; Thiazoles; Transplantation Chimera; Transplantation, Homologous	2010
Philadelphia-negative acute lymphoblastic leukemia in a chronic myeloid leukemia patient receiving dasatinib. Cytotherapy, 2010, Volume: 12, Issue:1 Topics: Aged; Antineoplastic Agents; Benzamides; Blast Crisis; Dasatinib; Hematopoietic Stem Cell Transplantation; Humans; Iatrogenic Disease; Imatinib Mesylate; Immunosuppressive Agents; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisone; Protein Kinase Inhibitors; Pyrimidines; Remission Induction; Thiazoles; Treatment Outcome	2010
Dasatinib-induced complete molecular response after allogeneic hematopoietic stem cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to prior imatinib-containing regimen: a case report and discussion. Medical oncology (Northwood, London, England), 2010, Volume: 27, Issue:4 Topics: Benzamides; Dasatinib; Drug Resistance, Neoplasm; Female; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Middle Aged; Neoplasm, Residual; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Remission Induction; Salvage Therapy; Survival Rate; Thiazoles; Transplantation, Autologous	2010
Dasatinib and chronic myeloid leukemia: two-year follow-up in eight clinical trials. Clinical lymphoma & myeloma, 2009, Volume: 9, Issue:6 Topics: Clinical Trials as Topic; Dasatinib; Female; Follow-Up Studies; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles	2009
Management of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL). Hematology. American Society of Hematology. Education Program, 2009 Topics: Adolescent; Adrenal Cortex Hormones; Adult; Antibodies, Bispecific; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Central Nervous System; Child; Combined Modality Therapy; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Leukemic Infiltration; Mutation; Neoplasm Proteins; Neoplasm, Residual; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Salvage Therapy; Secondary Prevention; Thiazoles; Transplantation Conditioning	2009
Voreloxin, a first-in-class anticancer quinolone derivative, acts synergistically with cytarabine in vitro and induces bone marrow aplasia in vivo. Cancer chemotherapy and pharmacology, 2010, Volume: 66, Issue:5 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Bone Marrow Cells; Cell Proliferation; Cytarabine; Disease Models, Animal; Drug Synergism; Female; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Leukocytes; Mice; Naphthyridines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thiazoles	2010
Development of resistance to dasatinib in Bcr/Abl-positive acute lymphoblastic leukemia. Leukemia, 2010, Volume: 24, Issue:4 Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Dasatinib; Drug Resistance, Neoplasm; Embryo, Mammalian; Fibroblasts; Fusion Proteins, bcr-abl; Humans; Leukemia, Experimental; Mice; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyrimidines; Receptors, CXCR4; src-Family Kinases; Stromal Cells; Thiazoles	2010
Treatment of Philadelphia-positive acute lymphocytic leukemia with tyrosine kinase inhibitors: What is the optimal regimen? American journal of hematology, 2010, Volume: 85, Issue:3 Topics: Antineoplastic Agents; Benzamides; Dasatinib; Disease Management; Disease Progression; Drug Administration Schedule; Drug Resistance, Neoplasm; Humans; Imatinib Mesylate; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Randomized Controlled Trials as Topic; Thiazoles	2010
A diphtheria toxin interleukin-3 fusion protein synergizes with tyrosine kinase inhibitors in killing leukemic progenitors from BCR/ABL positive acute leukemia. Leukemia research, 2010, Volume: 34, Issue:8 Topics: Adult; Aged; Benzamides; Blotting, Western; Cell Cycle; Cell Proliferation; Cells, Cultured; Dasatinib; Diphtheria Toxin; Drug Synergism; Female; Flow Cytometry; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Interleukin-3; Interleukin-3 Receptor alpha Subunit; Leukemia, Myeloid, Acute; Male; Middle Aged; Neoplastic Stem Cells; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Pyrimidines; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles	2010
[Clinical profiles of 7 patients with chronic myelogenous leukemia or Philadelphia chromosome-positive acute lymphoblastic leukemia treated with dasatinib]. [Rinsho ketsueki] The Japanese journal of clinical hematology, 2010, Volume: 51, Issue:3 Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colitis; Cytomegalovirus Infections; Dasatinib; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; Philadelphia Chromosome; Pleural Effusion; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Retrospective Studies; Thiazoles; Treatment Outcome	2010
Reversible cardiotoxicity with tyrosine kinase inhibitors. Clinical advances in hematology & oncology : H&O, 2010, Volume: 8, Issue:2 Topics: Adult; Benzamides; Cardiotoxins; Central Nervous System Neoplasms; Dasatinib; Fatal Outcome; Female; Humans; Imatinib Mesylate; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Ventricular Dysfunction, Left	2010
Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemias. Molecular cancer therapeutics, 2010, Volume: 9, Issue:5 Topics: Animals; Antineoplastic Agents; Apoptosis; Aurora Kinases; Cells, Cultured; Dasatinib; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Embryo, Mammalian; Fusion Proteins, bcr-abl; Humans; Mice; Mice, Knockout; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrimidines; Thiazoles; Treatment Outcome	2010
How I treat Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood, 2010, Nov-04, Volume: 116, Issue:18 Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Central Nervous System Neoplasms; Clinical Trials as Topic; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Hematopoietic Stem Cell Transplantation; Humans; Imatinib Mesylate; Mutation; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Protein Kinase Inhibitors; Pyrimidines; Remission Induction; Thiazoles	2010
Molecular monitoring and mutation analysis of patients with advanced phase CML and Ph+ ALL receiving dasatinib. European journal of haematology, 2010, Volume: 85, Issue:5 Topics: Adolescent; Adult; Aged; Clone Cells; Dasatinib; DNA Mutational Analysis; Female; Fusion Proteins, bcr-abl; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Accelerated Phase; Male; Middle Aged; Polymerase Chain Reaction; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; RNA, Neoplasm; Thiazoles; Young Adult	2010
Dasatinib followed by second allogeneic hematopoietic stem cell transplantation for relapse of Philadelphia chromosome-positive acute lymphoblastic leukemia after the first transplantation. International journal of hematology, 2010, Volume: 92, Issue:3 Topics: Adolescent; Dasatinib; Female; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Recurrence; Remission Induction; Thiazoles; Transplantation, Homologous	2010
Dasatinib is effective against optic nerve infiltration of Philadelphia chromosome-positive acute lymphoblastic leukemia. Leukemia & lymphoma, 2010, Volume: 51, Issue:10 Topics: Aged; Dasatinib; Female; Humans; Leukemic Infiltration; Optic Nerve; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Treatment Outcome; Visual Acuity	2010
Excellent response to dasatinib of childhood Philadelphia positive intracranial acute lymphoblastic leukaemia tumours. British journal of haematology, 2011, Volume: 152, Issue:3 Topics: Antineoplastic Agents; Brain; Child, Preschool; Dasatinib; Female; Humans; Leukemic Infiltration; Magnetic Resonance Imaging; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Thiazoles; Tomography, X-Ray Computed	2011
Chemotherapeutic agents circumvent emergence of dasatinib-resistant BCR-ABL kinase mutations in a precise mouse model of Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood, 2011, Mar-31, Volume: 117, Issue:13 Topics: Animals; Antineoplastic Agents; Cyclin-Dependent Kinase Inhibitor p16; Dasatinib; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis; Mutation, Missense; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Thiazoles; Transplantation, Isogeneic	2011
Successful treatment with dasatinib and allogeneic peripheral blood stem cell transplant for imatinib-resistant Philadelphia chromosome-positive acute lymphoblastic leukemia relapsing after bone marrow transplant and donor lymphocyte infusion. Leukemia & lymphoma, 2011, Volume: 52, Issue:7 Topics: Antineoplastic Agents; Benzamides; Bone Marrow Transplantation; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Lymphocyte Transfusion; Male; Middle Aged; Peripheral Blood Stem Cell Transplantation; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein-Tyrosine Kinases; Pyrimidines; Recurrence; Thiazoles; Transplantation, Homologous; Treatment Outcome	2011
Lack of non-hematological cross intolerance of dasatinib to imatinib in imatinib-intolerant patients with Philadelphia chromosome positive chronic myeloid leukemia or acute lymphatic leukemia: a retrospective safety analysis. International journal of hematology, 2011, Volume: 93, Issue:6 Topics: Adult; Aged; Antineoplastic Agents; Benzamides; Dasatinib; Hematologic Diseases; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Retrospective Studies; Thiazoles	2011
Plasma tyrosine kinase activity as a potential biomarker in BCR-ABL1-targeted therapy. Cancer biomarkers : section A of Disease markers, 2010, Volume: 7, Issue:6 Topics: Adaptor Proteins, Signal Transducing; Benzamides; Biomarkers, Tumor; Dasatinib; Dose-Response Relationship, Drug; Enzyme Assays; Flow Cytometry; Fusion Proteins, bcr-abl; Gene Expression Regulation, Leukemic; Humans; Imatinib Mesylate; Jurkat Cells; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mutation; Nuclear Proteins; Phosphorylation; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-abl; Pyrimidines; STAT5 Transcription Factor; Thiazoles	2010
Gene expression signatures and ex vivo drug sensitivity profiles in children with acute lymphoblastic leukemia. Journal of applied genetics, 2012, Volume: 53, Issue:1 Topics: Antineoplastic Agents; Biopsy; Bone Marrow Cells; Child; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Genes, Neoplasm; Humans; Male; Oligonucleotide Array Sequence Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Tetrazolium Salts; Thiazoles	2012
Influence of H2-receptor antagonists and proton pump inhibitors on dasatinib pharmacokinetics in Japanese leukemia patients. Cancer chemotherapy and pharmacology, 2012, Volume: 69, Issue:4 Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Aged, 80 and over; Dasatinib; Dose-Response Relationship, Drug; Drug Interactions; Famotidine; Female; Histamine H2 Antagonists; Humans; Japan; Lansoprazole; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Nizatidine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Proton Pump Inhibitors; Pyrimidines; Retrospective Studies; Thiazoles; Young Adult	2012
Prophylactic and preemptive therapy with dasatinib after hematopoietic stem cell transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2012, Volume: 18, Issue:4 Topics: Adolescent; Adult; Combined Modality Therapy; Dasatinib; Disease-Free Survival; Female; Follow-Up Studies; Fusion Proteins, bcr-abl; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Remission Induction; Secondary Prevention; Thiazoles; Transplantation Conditioning; Transplantation, Autologous; Transplantation, Homologous	2012
Clinical impact of in vitro cellular drug resistance on childhood acute lymphoblastic leukemia in Taiwan. Leukemia & lymphoma, 2012, Volume: 53, Issue:8 Topics: Adolescent; Antineoplastic Agents; Asparaginase; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Humans; In Vitro Techniques; Inhibitory Concentration 50; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Recurrence; Sex Factors; Taiwan; Tetrazolium Salts; Thiazoles; Treatment Outcome	2012
Hair depigmentation and vitiligo-like lesions in a leukaemic paediatric patient during chemotherapy with dasatinib. Acta dermato-venereologica, 2012, Volume: 92, Issue:2 Topics: Adolescent; Dasatinib; Drug Eruptions; Hair Diseases; Humans; Hypopigmentation; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Vitiligo	2012
Bilateral subdural hemorrhage as a serious adverse event of dasatinib in a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia. International journal of hematology, 2012, Volume: 95, Issue:5 Topics: Dasatinib; Female; Hemorrhage; Humans; Middle Aged; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Subdural Space; Thiazoles; Thrombocytopenia	2012
Pharmacokinetics of dasatinib for Philadelphia-positive acute lymphocytic leukemia with acquired T315I mutation. Journal of hematology & oncology, 2012, May-15, Volume: 5 Topics: Adult; Aged; Aged, 80 and over; Dasatinib; Drug Resistance, Neoplasm; Female; Fusion Proteins, bcr-abl; Humans; Male; Middle Aged; Mutation; Philadelphia Chromosome; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Tissue Distribution; Young Adult	2012
H2-receptor antagonist influences dasatinib pharmacokinetics in a patient with Philadelphia-positive acute lymphoblastic leukemia. Cancer chemotherapy and pharmacology, 2012, Volume: 70, Issue:2 Topics: Female; Histamine H2 Antagonists; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proton Pump Inhibitors; Pyrimidines; Thiazoles	2012
Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia. Cancer cell, 2012, Nov-13, Volume: 22, Issue:5 Topics: Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 19; Dasatinib; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Phosphorylation; Pre-B Cell Receptors; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrimidines; Receptor Tyrosine Kinase-like Orphan Receptors; Signal Transduction; Thiazoles; Translocation, Genetic	2012
Dasatinib medication causing profound immunosuppression in a patient after haploidentical SCT: functional assays from whole blood as diagnostic clues. Bone marrow transplantation, 2013, Volume: 48, Issue:6 Topics: Allografts; CD8-Positive T-Lymphocytes; Child; Dasatinib; DNA Virus Infections; Humans; Immunologic Deficiency Syndromes; Lymphocyte Count; Lymphocytosis; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Stem Cell Transplantation; Thiazoles	2013
As leukemia options grow, drugs jockey to be first-line therapies. Nature medicine, 2013, Volume: 19, Issue:1 Topics: Antineoplastic Agents; Benzamides; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Imidazoles; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Pyridazines; Pyrimidines; Thiazoles	2013
Maintenance therapy with dasatinib after allogeneic hematopoietic stem cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia. Annals of hematology, 2013, Volume: 92, Issue:8 Topics: Adult; Aged; Antineoplastic Agents; Cohort Studies; Combined Modality Therapy; Dasatinib; Drug Evaluation; Female; Follow-Up Studies; Fusion Proteins, bcr-abl; Graft vs Host Disease; Humans; Maintenance Chemotherapy; Male; Middle Aged; Neoplasm, Residual; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Recurrence; Remission Induction; Retrospective Studies; Thiazoles; Transplantation, Homologous	2013
Cross-resistance to five glucocorticoids in childhood acute lymphoblastic and non-lymphoblastic leukemia samples tested by the MTT assay: preliminary report. Acta biochimica Polonica, 2002, Volume: 49, Issue:1 Topics: Adolescent; Child; Child, Preschool; Drug Resistance, Neoplasm; Female; Glucocorticoids; Humans; Infant; Leukemia, Myeloid, Acute; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles	2002
The influence of intracellular idarubicin and daunorubicin levels on drug cytotoxicity in childhood acute leukemia. Acta biochimica Polonica, 2002, Volume: 49, Issue:1 Topics: Adolescent; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Child; Child, Preschool; Daunorubicin; Flow Cytometry; Humans; Idarubicin; Infant; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles	2002
Organic phenyl arsonic acid compounds with potent antileukemic activity. Bioorganic & medicinal chemistry letters, 2003, Feb-10, Volume: 13, Issue:3 Topics: Antineoplastic Agents; Arsenicals; Cell Lineage; Genes, p53; Humans; Leukemia; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	2003
Ex vivo drug resistance profile in childhood acute myelogenous leukemia: no drug is more effective in comparison to acute lymphoblastic leukemia. Leukemia & lymphoma, 2002, Volume: 43, Issue:9 Topics: Carboplatin; Cell Survival; Child; Cisplatin; Coloring Agents; Drug Resistance, Neoplasm; Humans; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Tetrazolium Salts; Thiazoles; Time Factors; Treatment Outcome; Tumor Cells, Cultured	2002
The analysis of correlations between drug resistance and clinical/laboratory measures found in a group of children with all treated by ALL-BFM 90 protocol. Bulletin du cancer, 2004, Volume: 91, Issue:4 Topics: Adolescent; Age Factors; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Coloring Agents; Cyclophosphamide; Cytarabine; Daunorubicin; Drug Resistance, Neoplasm; Female; Humans; In Vitro Techniques; Male; Mercaptopurine; Methotrexate; Multivariate Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prednisone; Remission Induction; Sex Factors; Tetrazolium Salts; Thiazoles; Vincristine	2004
Targeting FLT3 in primary MLL-gene-rearranged infant acute lymphoblastic leukemia. Blood, 2005, Oct-01, Volume: 106, Issue:7 Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Cell Line, Tumor; DNA; DNA Mutational Analysis; DNA Primers; Dose-Response Relationship, Drug; Drug Resistance; Enzyme Inhibitors; Gene Duplication; Gene Rearrangement; Humans; Immunoprecipitation; In Situ Hybridization, Fluorescence; Infant; Infant, Newborn; Ligands; Mutation; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prognosis; Reverse Transcriptase Polymerase Chain Reaction; RNA; Sequence Analysis, DNA; Staurosporine; Tetrazolium Salts; Thiazoles	2005
Evaluation of cytotoxicity by flow cytometric drug sensitivity assay in childhood T-cell acute lymphoblastic leukemia. Leukemia & lymphoma, 2005, Volume: 46, Issue:6 Topics: Apoptosis; Bone Marrow Cells; Child; Daunorubicin; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Immunophenotyping; Inhibitory Concentration 50; Leukemia, T-Cell; Medical Oncology; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reproducibility of Results; Sensitivity and Specificity; Tetrazolium Salts; Thiazoles	2005
c-Myc inhibition negatively impacts lymphoma growth. Journal of pediatric surgery, 2006, Volume: 41, Issue:1 Topics: Animals; Burkitt Lymphoma; Down-Regulation; Fibroblasts; Gene Expression Profiling; Herpesvirus 4, Human; Oligonucleotide Array Sequence Analysis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Mas; Proto-Oncogene Proteins c-myc; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	2006
Complete regression of cutaneous lesions of refractory Ph+ ALL after 4 weeks of treatment with BMS-354825. Blood, 2006, Jun-01, Volume: 107, Issue:11 Topics: Aged; Dasatinib; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Remission Induction; Skin Neoplasms; Thiazoles	2006
Circumventing resistance to kinase-inhibitor therapy. The New England journal of medicine, 2006, Jun-15, Volume: 354, Issue:24 Topics: Antineoplastic Agents; Benzamides; Dasatinib; Drug Resistance, Neoplasm; Fusion Proteins, bcr-abl; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mutation; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles	2006
Ex vivo activity of thalidomide in childhood acute leukemia. Leukemia & lymphoma, 2006, Volume: 47, Issue:6 Topics: Angiogenesis Inhibitors; Cell Cycle; Child; Child, Preschool; Cytarabine; Female; Humans; Immunophenotyping; Infant; Leukemia, Myeloid, Acute; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Tetrazolium Salts; Thalidomide; Thiazoles	2006
Dasatinib. Nature reviews. Drug discovery, 2006, Volume: 5, Issue:9 Topics: Administration, Oral; Adult; Clinical Trials as Topic; Dasatinib; Drug Approval; Guideline Adherence; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Molecular Structure; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Treatment Outcome	2006
Presence or the emergence of a F317L BCR-ABL mutation may be associated with resistance to dasatinib in Philadelphia chromosome-positive leukemia. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Nov-20, Volume: 24, Issue:33 Topics: Adult; Antineoplastic Agents; Blast Crisis; Clinical Trials, Phase II as Topic; Dasatinib; Disease Progression; Drug Resistance, Neoplasm; Female; Genes, abl; Humans; Leucine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Middle Aged; Mutation; Phenylalanine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Treatment Failure	2006
Dasatinib (Sprycel) for CML and Ph + ALL. The Medical letter on drugs and therapeutics, 2007, Jan-15, Volume: 49, Issue:1252 Topics: Benzamides; Clinical Trials as Topic; Dasatinib; Drug Interactions; Humans; Imatinib Mesylate; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Multicenter Studies as Topic; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Treatment Outcome	2007
Expression of multidrug resistance (MDR) proteins and in vitro drug resistance in acute leukemias. Hematology (Amsterdam, Netherlands), 2007, Volume: 12, Issue:1 Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Survival; Child; Child, Preschool; Coloring Agents; Cytarabine; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Infant; Inhibitory Concentration 50; Leukemia; Leukemia, Myeloid; Male; Methylphenazonium Methosulfate; Middle Aged; Neoplasm Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Staining and Labeling; Tetrazolium Salts; Thiazoles; Treatment Outcome; Tumor Cells, Cultured	2007
Clonal evolution with +11q 13, t(1;7) and t(1;4) at relapse in a patient with Ph positive acute lymphocytic leukemia (ALL) treated with single agent front line imatinib followed by dasatinib. Hematology (Amsterdam, Netherlands), 2007, Volume: 12, Issue:6 Topics: Benzamides; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 4; Clone Cells; Dasatinib; Humans; Imatinib Mesylate; Male; Middle Aged; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recurrence; Thiazoles; Translocation, Genetic	2007
Initial testing of dasatinib by the pediatric preclinical testing program. Pediatric blood & cancer, 2008, Volume: 50, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Child; Dasatinib; Female; Humans; Mice; Mice, Inbred Strains; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; Xenograft Model Antitumor Assays	2008
Dasatinib restores full donor chimerism in a patient with imatinib-resistant Ph+ ALL relapsing after unrelated cord blood transplantation. Leukemia & lymphoma, 2007, Volume: 48, Issue:10 Topics: Adult; Antineoplastic Agents; Benzamides; Cell Line, Tumor; Chimerism; Cord Blood Stem Cell Transplantation; Dasatinib; Drug Resistance, Neoplasm; Female; Humans; Imatinib Mesylate; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Recurrence; Remission Induction; Thiazoles; Time Factors	2007
Imatinib in relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukaemia: a viewpoint by Joseph Brandwein. Drugs, 2007, Volume: 67, Issue:17 Topics: Antineoplastic Combined Chemotherapy Protocols; Benzamides; Bone Marrow Transplantation; Dasatinib; Drug Resistance, Neoplasm; Humans; Imatinib Mesylate; Philadelphia Chromosome; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Recurrence; Thiazoles; Transplantation, Homologous	2007
Relationship between in vitro chemosensitivity assessed with MTT assay and clinical outcomes in 103 patients with acute leukemia. The Korean journal of laboratory medicine, 2007, Volume: 27, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Child; Child, Preschool; Coloring Agents; Cytarabine; Daunorubicin; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; Humans; Infant; Leukemia, Biphenotypic, Acute; Leukemia, Myeloid, Acute; Male; Middle Aged; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles; Treatment Outcome	2007
Sprycel for chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia resistant to or intolerant of imatinib mesylate. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Jan-15, Volume: 14, Issue:2 Topics: Antineoplastic Agents; Benzamides; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Dasatinib; Drug Approval; Drug Resistance, Neoplasm; Humans; Imatinib Mesylate; Leukemia, Myeloid, Chronic-Phase; Multicenter Studies as Topic; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Thiazoles; United States; United States Food and Drug Administration	2008
Use of dasatinib in the patient with Philadelphia chromosome-positive acute lymphoblastic leukaemia with resistance to imatinib and renal failure. Journal of clinical pharmacy and therapeutics, 2008, Volume: 33, Issue:3 Topics: Aged; Antineoplastic Agents; Benzamides; Dasatinib; Drug Resistance, Neoplasm; Humans; Imatinib Mesylate; Male; Piperazines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinase Inhibitors; Pyrimidines; Remission Induction; Renal Insufficiency; Thiazoles	2008
Corticosteroid resistance is increased in lymphoblasts from adults compared with children: preliminary results of in vitro drug sensitivity study in adults with acute lymphoblastic leukaemia. British journal of haematology, 1995, Volume: 91, Issue:1 Topics: Adrenal Cortex Hormones; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Child; Coloring Agents; Disease-Free Survival; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Lymphocytes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prospective Studies; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	1995
Drug combination testing in acute lymphoblastic leukemia using the MTT assay. Leukemia research, 1995, Volume: 19, Issue:3 Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Daunorubicin; Drug Interactions; Drug Resistance; Humans; In Vitro Techniques; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vincristine	1995
Mononuclear cells contaminating acute lymphoblastic leukaemic samples tested for cellular drug resistance using the methyl-thiazol-tetrazolium assay. British journal of cancer, 1994, Volume: 70, Issue:6 Topics: Cell Separation; Child; Drug Resistance; Humans; Immunomagnetic Separation; In Vitro Techniques; Leukocytes, Mononuclear; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	1994
Prediction of chemotherapy response in human leukemia using in vitro chemosensitivity test. Leukemia research, 1993, Volume: 17, Issue:8 Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Coloring Agents; Cytarabine; Daunorubicin; Drug Screening Assays, Antitumor; Female; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitoxantrone; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Tetrazolium Salts; Thiazoles	1993
Cellular drug resistance profiles that might explain the prognostic value of immunophenotype and age in childhood acute lymphoblastic leukemia. Leukemia, 1993, Volume: 7, Issue:3 Topics: Aging; Antineoplastic Agents; Child; Child, Preschool; Daunorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Immunophenotyping; Infant; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Predictive Value of Tests; Prognosis; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Vincristine	1993
Comparison of the antileukemic activity in vitro of dexamethasone and prednisolone in childhood acute lymphoblastic leukemia. Medical and pediatric oncology, 1996, Volume: 27, Issue:2 Topics: Adolescent; Antineoplastic Agents, Hormonal; Child; Coloring Agents; Dexamethasone; Drug Screening Assays, Antitumor; Female; Humans; In Vitro Techniques; Infant; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	1996
Differential methotrexate resistance in childhood T- versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition assay, but not by the MTT assay. Blood, 1999, Feb-01, Volume: 93, Issue:3 Topics: Adolescent; Antimetabolites, Antineoplastic; Child; Child, Preschool; Coloring Agents; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Folic Acid Antagonists; HL-60 Cells; Humans; Infant; Infant, Newborn; Leukemia-Lymphoma, Adult T-Cell; Male; Methotrexate; Neoplasm Proteins; Neoplastic Stem Cells; Polyglutamic Acid; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sensitivity and Specificity; Staining and Labeling; Tetrazolium Salts; Thiazoles; Thymidylate Synthase; U937 Cells	1999
The S-alkyl chain length as a determinant of the anti-leukemic activity of cysteine chloromethyl ketone compounds. Bioorganic & medicinal chemistry letters, 2000, Mar-20, Volume: 10, Issue:6 Topics: Alkylation; Antineoplastic Agents; Cell Line; Coloring Agents; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2000
Cysteine chloromethyl and diazomethyl ketone derivatives with potent anti-leukemic activity. Bioorganic & medicinal chemistry letters, 2000, Mar-20, Volume: 10, Issue:6 Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Agents; Cell Line; Coloring Agents; Cysteine; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2000
Relation of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukaemia. Lancet (London, England), 1991, Aug-17, Volume: 338, Issue:8764 Topics: Antineoplastic Agents; Asparaginase; Chi-Square Distribution; Child; Coloring Agents; Daunorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Female; Humans; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Prognosis; Remission Induction; Tetrazolium Salts; Thiazoles; Thioguanine; Tumor Cells, Cultured; Vincristine	1991
In vitro drug sensitivity of cells from children with leukemia using the MTT assay with improved culture conditions. Blood, 1990, Dec-01, Volume: 76, Issue:11 Topics: Asparaginase; Cells, Cultured; Child; Coloring Agents; Culture Media; Cyclophosphamide; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Mechlorethamine; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Tetrazolium Salts; Thiazoles; Thioguanine; Vincristine	1990
Comparison of the rapid automated MTT-assay with a dye exclusion assay for chemosensitivity testing in childhood leukaemia. British journal of cancer, 1989, Volume: 59, Issue:2 Topics: Antineoplastic Agents; Cell Survival; Child; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	1989