thiazoles has been researched along with Acute Confusional Senile Dementia in 988 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (1.21) | 18.7374 |
| 1990's | 41 (4.15) | 18.2507 |
| 2000's | 272 (27.53) | 29.6817 |
| 2010's | 603 (61.03) | 24.3611 |
| 2020's | 60 (6.07) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, L; Gordon, ML; Li, Y; Liu, F; Lou, F; Wang, Y; Zhang, N; Zhang, Y | 1 |
| Aso, Y; Kimura, N; Matsubara, E | 1 |
| Arahata, Y; Bundo, M; Ikenuma, H; Ito, K; Iwata, K; Kato, T; Kimura, Y; Nakamura, A; Nihashi, T; Okamura, N; Sakurai, K; Sakurai, T; Suzuki, K; Takeda, A; Washimi, Y; Yamaoka, A; Yanai, K | 1 |
| Adriana, Q; Andres, D; Cecilia, B; de León, MP; Feuerstein, V; Germán, F; Graciela, L; Henry, E; Ismael, C; Leandro, U; Nicolás, N; Patricio, C; Ricardo, A; Sergio, D; Silvia, V; Valeria, C; Yanina, B | 1 |
| Jack, CR; Kantarci, K; Kantarci, OH; Kemp, BJ; Kremers, WK; Lesnick, TG; Lowe, VJ; Min, PH; Przybelski, SA; Schwarz, CG; Senjem, ML; Zeydan, B | 1 |
| Imabayashi, E; Ishibashi, K; Ishii, K; Kamitaka, Y; Kobayashi, R; Koike, E; Miwa, K; Miyaji, N; Nezu, S; Sugamata, Y; Toyohara, J; Wagatsuma, K; Yamao, T; Yoshii, T | 1 |
| Ancidoni, A; Carbone, E; Corbo, M; Crestini, A; Lacorte, E; Lo Giudice, M; Piscopo, P; Rivabene, R; Vanacore, N | 1 |
| Abdelaziz, MA; Abdulaziz, O; Alamri, AS; Alhomrani, M; Hussain, R; Hyder, S; Iqbal, R; Khan, S; Rahim, F; Rehman, W; Sarfraz, M; Shah, SAA; Taha, M; Ullah, H | 1 |
| Abdelaziz, MA; Alatawi, FS; Albalawi, MA; Ali Shah, SA; Ayub, K; Hussain, R; Iqbal, N; Iqbal, R; Khan, KM; Khan, S; Rahim, F; Sarfraz, M; Taha, M; Ullah, H | 1 |
| Doskas, T; Dubois, B; Hermine, O; Lipschitz, S; López-Arrieta, J; Mansfield, CD; Moroz, S; Moussy, A; Spiru, L; Tsolaki, M; Venger, O; Vermersch, P | 1 |
| Feng, F; Jiang, X; Liu, C; Liu, W; Lyu, W; Sun, H; Xie, H; Xu, J; Zou, M; Zuo, J | 1 |
| Huang, S; Li, F; Zhang, G; Zhang, J; Zhang, R; Zhao, M; Zhu, X; Zhu, Y | 1 |
| Garmer, M; Jul, PH; Rostgaard, N; Volbracht, C | 1 |
| Baron, JC; Bottlaender, M; Caillé, F; Gervais, P; Lagarde, J; Olivieri, P; Sarazin, M | 1 |
| Bae, J; Byun, MS; Han, SH; Hwang, D; Jeong, H; Kim, H; Kim, YK; Lee, DY; Lee, H; Lee, SW; Mook-Jung, I; Park, JC; Shin, SA; Yi, D | 1 |
| Adams, JN; Baker, SL; Du, R; Harrison, TM; Jagust, WJ; Maass, A | 1 |
| Hanaoka, K; Ishii, K; Kaida, H; Kimura, Y; Nagaoka, T; Nemoto, M; Watanabe, S; Yamada, T | 1 |
| Hattori, H; Ishii, K; Ito, K; Iwata, K; Iwatsubo, T; Kato, T; Kimura, Y; Nakamura, A; Okada, Y; Senda, M; Toyama, H | 1 |
| Abe, K; Asada, K; Deguchi, K; Higashi, Y; Hishikawa, N; Ikeda, M; Ikeda, Y; Kimura, N; Kojo, M; Kuroda, T; Lee, LJ; Matsubara, E; Morihara, R; Nakano, Y; Ohta, Y; Okamoto, K; Ono, K; Osakada, Y; Senga, T; Shang, J; Shi, X; Shoji, M; Takao, Y; Takatama, M; Takemoto, M; Tanaka, K; Wakutani, Y; Yamashita, T | 1 |
| McDonough, IM; Popp, TE | 1 |
| Allison, SL; Asthana, S; Betthauser, TJ; Carlsson, CM; Chin, NA; Christian, BT; Clark, LR; Cody, KA; Erickson, CM; Johnson, SC; Jonaitis, EM; Koscik, RL; Mueller, KD; Rowley, HA; Stone, CK | 1 |
| Chan, C; Chen, Y; Deshmukh, G; Elstrott, J; Gill, TM; Hackos, DH; Hanson, JE; Jiang, Z; Khan, AS; Kim, TA; Liederer, BM; Liu, B; Ma, K; Palop, JJ; Saillet, S; Scearce-Levie, K; Schwarz, JB; Sellers, BD; Sheng, M; Simms, J; Solanoy, H; Volgraf, M; Wang, TM; Weber, M; Weimer, RM; Yu, GQ | 1 |
| Gunter, JL; Jack, CR; Kantarci, K; Kantarci, OH; Knopman, DS; Lesnick, TG; Lowe, VJ; Machulda, MM; Mielke, MM; Parisi, JE; Petersen, RC; Przybelski, SA; Reichard, RR; Schwarz, CG; Senjem, ML; Vemuri, P; Zeydan, B | 1 |
| Byun, MS; Jeon, SY; Jung, GJ; Jung, JH; Kang, KM; Kim, YK; Lee, DY; Lee, JH; Lee, JY; Lee, Y; Shin, SA; Sohn, BK; Sohn, CH; Yi, D | 1 |
| Gu, X; Han, X; Liu, L; Zhao, M | 1 |
| Botha, H; Clark, HM; Duffy, JR; Ertekin-Taner, N; Graff-Radford, J; Jack, CR; Josephs, KA; Lowe, VJ; Machulda, MM; Schwarz, CG; Senjem, ML; Strand, EA; Tosakulwong, N; Utianski, RL; Weigand, SD; Whitwell, JL | 1 |
| Bothwell, PJ; Fisher, SS; Hamaker, CG; Huffman, SE; Jones, MA; Platt, DC; Webb, MI; Yawson, GK | 1 |
| Boles Ponto, LL; DeVries, SD; Harlynn, EL; Magnotta, VA; Menda, Y; Moser, DJ; Oleson, JJ; Schultz, SK; Wemmie, JA | 1 |
| Aichler, M; Niu, Z; Reif, B; Sarkar, R; Wester, HJ; Yousefi, BH | 1 |
| Abbasnezhad, A; Abd El-Ghafar, OA; Abhilash, L; Abouzid, KAM; Achberger, AM; Ackerman, S; Akhatayeva, Z; Akin, D; Al-Kaysi, RO; Alakhdar, AA; Alame, M; Aleksic Sabo, V; Alinezhadbalalami, N; Allen, JD; Alonso, JM; Alqatani, S; Alsayed, B; Álvarez Larraondo, M; Alvarez, M; Amini, SB; An, Z; Anasir, MI; Anderson, GH; Andremont, A; Andrés, S; Angel, S; Anigboro, AA; Anini, Y; Antonides, CFJ; Arafa, K; Arafa, RK; Aryal, UK; Asbaghi, O; Assefa, MK; Atyah, M; Avwioroko, OJ; Ayora-Talavera, G; Azpilikueta, A; Azyazov, VN; Ba, YF; Bachmann, KF; Badoual, J; Bae, SJ; Baek, SH; Bahrami, B; Bai, J; Baid-Agrawal, S; Bailey, MR; Baillie, JK; Balani, N; Balcar, VJ; Banica, T; Banks, L; Barb, J; Bardeen, CJ; Barrett, HE; Bartnikowski, N; Bashir, R; Battaglia, M; Bautista-Hernández, V; Becker, B; Beekman, FJ; Benidir, M; Benjelloun, M; Bentley, RF; Bergé, J; Berger, D; Bernsen, MR; Berraondo, P; Bhattacharya, R; Bhayani, SB; Bi, W; Bi, X; Bi, YL; Bi, Z; Bian, K; Biesecker, LG; Billadeau, DD; Blaszczyk, R; Blum, JL; Boachie, R; Boelte, K; Bogers, AJJC; Boileau, I; Bonduelle, C; Bonny, O; Bonsu, JM; Boos, LA; Borges-Argáez, R; Bouchard, PA; Boudot, C; Bourgeade-Delmas, S; Boutet-Robinet, E; Boyle, AJ; Branigan, D; Briones, S; Broniowska, KA; Brossas, JY; Brown, WA; Brzezinska, J; Buitron, G; Burnier, M; Bursulaya, B; Burton, PR; Bush, AA; Busuttil, RW; Cabello-Aguilar, S; Cáceres-Farfán, M; Cacheux, V; Caffrey, PJ; Cai, B; Cai, Q; Cai, S; Cai, Y; Calders, P; Cammarota, G; Campbell, DA; Cancelli, C; Cao, Q; Cao, WH; Cao, X; Capet, M; Capoluongo, E; Carey, ME; Carnero, M; Carrasco, LI; Carreno, J; Carrillo-Reyes, J; Casini, I; Cassar, M; Catalan, G; Cattamanchi, A; Cazares-Granillo, M; Celie, B; Cen, YK; Cena, H; Cerbo, RM; Ceron, E; Cetina-Montejo, L; Chaâbane-Banaoues, R; Chabanet, C; Chace-Donahue, F; Chalfun-Júnior, A; Chan-Balan, R; Chang, CS; Chen, CS; Chen, D; Chen, J; Chen, L; Chen, PN; Chen, Q; Chen, S; Chen, W; Chen, WP; Chen, X; Chen, Z; Cheng, H; Cheng, J; Cheng, Q; Cheng, T; Chi, T; Chianelli, D; Chieppa, M; Child, CJ; Cho, JH; Cho, JY; Chogtu, B; Choi, GH; Choi, J; Choi, M; Choi, NG; Cholu, CO; Chow, ES; Chowdhury, AH; Chu, PC; Chu, Q; Chu, S; Chua, H; Chung, T; Chunyan, L; Church, JS; Civardi, E; Cobiella, J; Colinge, J; Collado, CJ; Collins, TJ; Cong, LM; Conkrite, KL; Cope, SJ; Corbett, JA; Cornet, M; Cornillot, E; Corvaisier, S; Costes-Martineau, V; Courtioux, B; Coussens, M; Covino, M; Criado, A; Cui, J; Cui, Y; Cunitz, BW; Curry, AE; Cussó, L; D'Urzo, AD; D'Urzo, KA; Dabbous, S; Dahlgren, RA; Dai, H; Dai, T; Dai, W; Dalinghaus, M; Dang, S; Davalos, RV; Davidson, H; de Andrea, CE; De Angelis, M; de Blois, E; de Carvalho, PA; De Clercq, E; De Giuseppe, R; de Jong, M; De Langhe, S; De Oliveira, L; de Souza Pinto Lemgruber, R; de Souza, LB; de Swart, J; De Wandele, I; de Woestijne, PCV; Delaney, S; Delorme, M; Delvenne, P; Deng, L; Deng, Z; Denkinger, CM; der Meulen, MHV; Deraeve, C; Desco, M; DeSilva, S; Destere, A; Dhali, A; Di Ciano, P; Dias-Santagata, D; Diskin, SJ; Djè, MK; Doddipatla, S; Doerr, AJ; Dokla, EME; Domiciano, D; Domingo, N; Dong, C; Dong, J; Dong, Q; Dong, S; Dong, X; Dong, Z; Douair, I; Douglas, TA; Doyle, SM; Drain, PK; Du, K; Du, L; Du, Q; Du, S; Duan, C; Duan, H; Duan, J; Duan, S; Duan, W; Dueluzeau, R; Dukic, L; Dunmire, BL; Duvauchelle, T; Dymek, B; Dzwonek, K; Earnest, A; Eckardt, KU; El Ghadraoui, L; El Massoudi, S; Elloumi, F; Elnour, IE; Embarak, S; Ende, M; England, K; Enikeev, D; Enyedy, I; Epple, R; Erickson, GE; Eriksson, J; Erndt-Marino, J; Errachidi, F; Etxeberria, I; Evan, AP; Fairlamb, AH; Falahi, E; Fan, CC; Fan, H; Fan, M; Fan, MZ; Fan, S; Fan, Y; Fang, CS; Fang, J; Fang, X; Fang, Z; Farmany, A; Farooqi, A; Farouk, HO; Fazelipour, S; Feng, D; Feng, J; Feng, JX; Feng, YL; Ferraz, SL; Ferreira, CR; Figenshau, RS; Finn, AV; Fiseha, T; Fleischer, AS; Fogleman, AD; Fontaine, O; Ford, CR; Fouladvand, F; Four, M; Fousteri, G; Francis, JR; Fraser, JF; Frazier, RP; Fu, H; Fu, P; Fu, YJ; Fujishima, A; Fuster, V; Gabilan, JC; Gagliani, N; Gai, QY; Galán-Arriola, C; Gale, P; Galimova, GR; Galkin, A; Gallo, A; Gallo, AA; Gang, DD; Ganschow, S; Gao, C; Gao, F; Gao, GP; Gao, H; Gao, K; Gao, M; Gao, MY; Gao, P; Gao, R; Gao, S; Gao, WJ; Gao, Y; Garbacz, P; García Ruiz, L; Garcia, EM; Garofoli, F; Gasbarrini, A; Gattinoni, L; Gaudig, M; Gbureck, U; Ge, X; Genko, N; Gentile, GL; George, MW; Gerety, GF; Gestwicki, JE; Geusens, PP; Ghassemi, M; Giardina, JD; Giebultowicz, JM; Gifford, CA; Gijsen, FJH; Gilfillan, R; Gilson, E; Gingl, K; Giuliano, C; Glybochko, P; Goessler, W; Gofflot, S; Golab, J; Goldstein, A; Golebiowski, A; Gómez, L; Gómez-Carballo, J; Gonçalves, PEO; Gonzales, R; Gonzalez-Cotto, M; González-Fernández, D; Gonzalez-Lopez de Turiso, F; Goodman, JM; Govinda Raju, S; Grimm, J; Gross, AJ; Gruenheid, S; Gu, C; Gu, FF; Gu, S; Gu, Z; Guest, RL; Gui, C; Gui, J; Guillem, A; Guo, G; Guo, L; Guo, Q; Guo, S; Guo, SW; Guo, W; Guo, Y; Guo, YG; Guo, Z; Guretzky, JA; Haenggi, M; Hahn, MS; Hakkola, J; Halim, AA; Hampel, D; Han, B; Han, BH; Han, D; Han, G; Han, J; Han, LZ; Han, R; Han, S; Han, X; Han, Z; Handley, MA; Hanke, I; Hannongbua, S; Hao, P; Happ, JT; Hara, M; Haraux, F; Hare, JL; Harper, JD; Hartley, AM; Harvey, E; Hashimoto, K; Hassan, HM; Hautajärvi, H; Hayton, TW; He, C; He, H; He, HJ; He, WP; He, Y; He, Z; Hedrick, V; Heffernan, JK; Hegrová, J; Heidarimoghadam, R; Helms, K; Hengphasatporn, K; Henry, D; Herrmann, TRW; Hesson, T; Himmelbauer, MK; Hindle, A; Hoffmann, R; Hogg, N; Hong, KB; Hong, SK; Honjol, Y; Hood, C; Hsi, RS; Hsu, JL; Hu, B; Hu, BC; Hu, D; Hu, H; Hu, J; Hu, K; Hu, M; Hu, MK; Hu, T; Hu, W; Hu, Y; Hu, Z; Hua, S; Huang, H; Huang, J; Huang, L; Huang, M; Huang, P; Huang, X; Huang, Y; Huang, Z; Hukkanen, J; Hung, MC; Huo, X; Hyötyläinen, T; Ianiro, G; Ibanez, B; Imran, M; Ireland, S; Irwin, MS; Ishiguro, H; Jackowski, K; Jackson, C; Jacob, SI; Jahromy, MH; Jakob, SM; Jang, J; Javvaji, PK; Jefferson, KK; Jena, P; Ji, H; Jiang, F; Jiang, GH; Jiang, H; Jiang, J; Jiang, X; Jiang, Z; Jiao, J; Jiménez, A; Jin, X; Jincai, W; Jintao, X; Jo, K; Jofra, T; Johari, Y; Johnson, ACM; Jones, JH; Josephine Fauci, A; Juhl, AK; Jun, S; Kaiser, RI; Kajioka, J; Kajiyama, H; Kalliyil, A; Kalthur, SG; Kamalanathan, M; Kamaldinov, T; Kanaani, L; Kang, D; Kang, J; Kang, S; Känsäkoski, P; Kaplan, DL; Karwan, M; Kasibhatla, S; Kaur, A; Kawazoe, Y; Ke, C; Keyser, J; Khalique, A; Khan, IT; Kharshoum, RM; Kher, R; Kherani, J; Ki, KK; Kikkawa, F; Kikkawa, R; Kim, BT; Kim, EH; Kim, GA; Kim, GD; Kim, HB; Kim, HG; Kim, JS; Kim, MJ; Kim, SI; Kim, SJ; Kim, Y; King, K; Kinyamu-Akunda, J; Kirkkala, T; Kjaer-Sorensen, K; Kleppinger, EL; Kloner, RA; Klopfenstein, TJ; Knappe, D; Knezevic, P; Kobos, LM; Kohli, M; Kolano, L; Kolodgie, FD; Kolte, AP; Koneru, B; Kong, D; Kong, F; Kong, X; Konggidinata, MI; Köpke, M; Koski, KG; Kotsis, F; Köttgen, A; Kouakou-Kouamé, CA; Kraemer, US; Krane, V; Krehbiel, CR; Krenning, BJ; Kretzschmar, D; Ku, KB; Kubota, Y; Kulich, P; Kumar, NG; Kupiec-Weglinski, JW; Lalani, SS; Lan, X; Landfeldt, E; Langenberg, E; Lapauw, B; Larkin, J; Lassoued, MA; Laukhtina, E; Laura Martinez, J; Laveillé, A; Lavela, P; Law, AD; Lazraq, A; Le Foll, B; Lee, BK; Lee, C; Lee, CS; Lee, EJ; Lee, EY; Lee, G; Lee, HY; Lee, JH; Lee, JJ; Lee, JO; Lee, JS; Lee, R; Lei, H; Lei, P; Lellouche, F; Lennerz, JK; Leong, W; Leslie, I; Lessem, E; Levin, M; Levinger, I; Li, C; Li, CW; Li, CX; Li, CY; Li, D; Li, H; Li, HM; Li, J; Li, L; Li, LM; Li, N; Li, S; Li, W; Li, X; Li, XX; Li, Y; Li, Z; Li, ZL; Li, ZX; Lian, Q; Liang, C; Liang, GH; Liang, H; Liang, J; Liang, X; Liao, CX; Liao, R; Ličbinský, R; Lim, YS; Lima, HK; Lin, JG; Lin, L; Lin, S; Lin, WP; Lin, Z; Liso, M; Liu, BX; Liu, C; Liu, H; Liu, J; Liu, M; Liu, Q; Liu, S; Liu, SF; Liu, SL; Liu, T; Liu, W; Liu, X; Liu, XB; Liu, Y; Liu, YY; Liu, Z; Liu, ZQ; Lobo, M; Loitzenbauer, M; López, F; Lopez, G; López, GJ; Lou, Z; Lu, IC; Lu, J; Lu, M; Lu, W; Lu, X; Lu, Y; Luhovyy, BL; Luna-Abanto, J; Luo, J; Luo, K; Luo, L; Luo, M; Luo, W; Luo, X; Luo, XM; Lv, Y; Lv, YQ; Lyu, HD; Lyu, J; Ma, C; Ma, G; Ma, L; Ma, Q; Ma, X; Ma, Y; Macha, SJ; MacLean, E; Mahalapbutr, P; Maina, T; Malfait, F; Malfertheiner, MV; Malzert-Fréon, A; Mansouri, E; Mao, C; Marcellin, E; Marchiori, PER; Marcotte, DJ; Maréchal, A; Maric, N; Maris, JM; Maron, L; Marti, CN; Martínez-Milla, J; Mateo, J; Mather, K; Mathison, CJN; Matthay, MA; Maxwell, CL; Mazier, D; Mazumder, D; Mazurkiewicz, M; Mazzucchelli, TG; McAuley, DF; Mccoy, K; McVicar, DW; Mebel, AM; Mech, A; Meester, EJ; Meiselbach, H; Melero, I; Ménard, G; Meng, X; Mengya, Y; Merle, G; Meunier, B; Mfarrej, B; Mi, K; Migueliz, I; Mikuška, P; Miladi, K; Miletich, R; Millar, JE; Mills, MR; Milne, R; Minute, L; Misiak, M; Mo, F; Modi, A; Mok, F; Molina, C; Mollen, CJ; Molteni, V; Montalto, M; Montet, D; Monti, MC; Moor, MB; Moravec, P; Morsiani, C; Murillo, E; Murugan, P; Muslem, R; Myers, RK; N'guessan, FK; Nabil, H; Nadal, J; Nadeem, M; Nafady, MM; Nafie, MS; Nair, HP; Nakano, R; Nance, J; Naren, N; Neil, CJ; Nelson, J; Nery, FC; Netsch, C; Nguyen, TH; Ni, L; Ni, YX; Nie, W; Nielsen, LK; Nigam, K; Nikolayev, AA; Nishiyama, M; Niu, LL; Niu, PP; Nock, BA; Noer, PR; Noll, G; Noll, S; Norenberg, JP; Nowicka, J; Nutho, B; O'Connor, M; Obonyo, NG; Ochiai, T; Ochoa, MC; Oh, BL; Oh, S; Olczak, J; Olivares, X; Ommurugan, B; Oosthuizen, MC; Operario, D; Orešič, M; Oshima, K; Otano, I; Ou, Y; Owen, TW; Oxvig, C; Pacey, V; Pai, M; Paik, H; Paiva, R; Palmieri, EM; Palpant, N; Pan, L; Pan, Q; Panahi, S; Pang, B; Pang, ZC; Pannecouque, C; Paris, L; Park, D; Park, DJ; Park, E; Park, EC; Park, IH; Park, JH; Park, JI; Park, S; Passmore, MR; Pattaranggoon, NC; Paun, M; Pedersen, S; Pedron, J; Peng, M; Peng, X; Penzhorn, BL; Pérez-Camargo, D; Perez-Maldonado, R; Pérez-Vicente, C; Pham, TD; Pickering, L; Pickersgill, NA; Pinault, E; Pinotsis, N; Plan, M; Pocino, K; Poh, CL; Pons, EDC; Popoff, MR; Porri, D; Pourmand, A; Pratviel, G; Prudente, DO; Qi, H; Qi, N; Qian, LY; Qiao, L; Qiao, Q; Qin, QP; Qiu, N; Qiu, SW; Qu, F; Quan, M; 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| Arahata, Y; Bajo, R; Bundo, M; Cuesta, P; Diers, K; Endo, H; Fernández, A; Fukuda, K; Hattori, H; Ito, K; Iwata, K; Kato, T; Kuratsubo, I; Maestú, F; Nakamura, A; Sakurai, T; Takeda, A; Washimi, Y | 1 |
| Ances, BM; Bateman, R; Benzinger, TLS; Buckles, VD; Cairns, NJ; Chhatwal, JP; Danek, A; Farlow, MR; Galasko, DR; Ghetti, B; Hedden, T; Jack, C; Jaimes, S; Johnson, KA; Kinnunen, KM; Koeppe, RA; Laske, C; Levin, J; Marcus, DS; Martins, RN; Masters, CL; McDade, E; Morris, JC; Ringman, JM; Salloway, S; Schofield, PR; Schultz, AP; Sperling, RA; Xiong, C; Yakushev, I | 1 |
| Coppola, G; Huang, SC; Jann, K; Liu, CY; Mack, WJ; Ringman, JM; Wang, DJJ; Wong, KP; Yan, L | 1 |
| Arnemann, KL; Jagust, WJ; Narayan, S; Rabinovici, GD; Stöber, F | 1 |
| Bottlaender, M; Caillé, F; Chupin, M; Corlier, F; Dorothée, G; Dubois, B; Fillon, L; Hamelin, L; Kuhnast, B; Lagarde, J; Potier, MC; Sarazin, M | 1 |
| Gardberg, M; Rinne, JO; Röyttä, M; Scheinin, NM | 1 |
| Benzinger, TLS; Blazey, TM; Cruchaga, C; Gordon, BA; Holtzman, DM; Mishra, S; Morris, JC; Su, Y | 1 |
| Bell, RK; Jagust, WJ; Leal, SL; Lockhart, SN; Maass, A | 1 |
| Aakre, JA; Alhurani, R; Coloma, P; Geda, YE; Jack, CR; Knopman, DS; Kremers, WK; Lowe, VJ; Machulda, MM; Mielke, MM; Petersen, RC; Roberts, RO; Schauble, B; Vassilaki, M | 1 |
| Bartenstein, P; Brendel, M; Hanaoka, K; Hosokawa, C; Ishii, K; Kaida, H; Murakami, T; Rominger, A; Sauerbeck, J; Scheiwein, FT | 1 |
| Almkvist, O; Blennow, K; Eriksdotter, M; Ferreira, D; Graff, C; Kinhult-Ståhlbom, A; Nordberg, A; Rodriguez-Vieitez, E; Saint-Aubert, L; Schöll, M; Thonberg, H; Thordardottir, S; Wall, A; Westman, E; Zetterberg, H | 1 |
| Byun, MS; Kang, SK; Kim, YK; Lee, DS; Lee, DY; Lee, JS; Seo, S; Shin, SA | 1 |
| McDonough, IM | 1 |
| Cai, L; Gao, S; Ji, Y; Li, Y; Shi, Z; Wang, Y; Xing, X; Yang, H; Yao, S; Zhang, N | 1 |
| Gabr, MT; Pigge, FC | 1 |
| Abe, T; Ataka, S; Hasegawa, I; Itoh, Y; Kawabe, J; Kikukawa, T; Mino, T; Saito, H; Takeuchi, J; Wada, Y; Watanabe, Y | 1 |
| Fukasawa, R; Hanyu, H; Higuchi, M; Ishii, K; Ogawa, Y; Shimada, H; Shimizu, S; Suhara, T; Takenoshita, N; Umahara, T | 1 |
| Bateman, RJ; Benzinger, TLS; Chhatwal, J; Cruchaga, C; Day, GS; Fagan, AM; Goate, AM; Gordon, BA; Hornbeck, R; Hsu, S; Karch, CM; Laforce, R; Levitch, D; Louden, A; McDade, E; Morris, JC; Norton, JB; Ziegemeier, E | 1 |
| Boellaard, R; De Deyn, PP; de Jong, BM; Dierckx, RA; García, DV; Huitema, RB; Meles, SK; Peretti, DE; Reesink, FE; Sánchez-Catasús, CA; Willemsen, AT | 1 |
| Li, M; Wang, P; Wu, J; Zeng, J | 1 |
| Ances, BM; Babulal, GM; Benzinger, TLS; Fagan, AM; Grant, EA; Hassenstab, J; Head, D; Holtzman, DM; Morris, JC; Roe, CM; Schindler, SE; Stout, SH; Xiong, C | 1 |
| Abulafia, C; Castro, MN; Curiel-Cid, R; Drucaroff, LJ; Duarte-Abritta, B; Guinjoan, SM; Loewenstein, D; Nemeroff, CB; Sánchez, SM; Sevlever, G; Vázquez, S; Vigo, DE; Villarreal, MF | 1 |
| Byun, MS; Han, SH; Lee, DY; Lee, JH; Mook-Jung, I; Park, JC; Yi, D | 1 |
| Nai, YH; Okamura, N; Tashiro, M; Watabe, H; Watanuki, S | 1 |
| Ayakta, N; Borys, E; Boxer, AL; DeCarli, C; Doré, V; Grinberg, LT; Huang, E; Hwang, JH; Ikonomovic, MD; Jack, C; Jagust, WJ; Jin, LW; Klunk, WE; Kofler, J; La Joie, R; Lesman-Segev, OH; Lockhart, SN; Lowe, VJ; Masters, CL; Mathis, CA; McLean, CL; Miller, BL; Mungas, D; Murray, ME; O'Neil, JP; Olichney, JM; Parisi, JE; Petersen, RC; Rabinovici, GD; Rosen, HJ; Rowe, CC; Seeley, WW; Spina, S; Vemuri, P; Villemagne, VL | 1 |
| Aizenstein, HJ; Cruchaga, C; Del-Aguila, JL; Demirci, FY; Fan, KH; Feingold, E; Kamboh, MI; Klunk, WE; Lopez, OL; Mathis, CA; Nho, K; Risacher, SL; Saykin, AJ; Snitz, BE; Wang, X; Yan, Q | 1 |
| Jang, H; Jang, YK; Kim, HJ; Lee, JS; Lockhart, SN; Na, DL; Noh, Y; Park, JY; Seo, SW; Seong, JK | 1 |
| Chen, CP; Cheung, CY; Han, JC; Jang, YK; Jung, NY; Kee, C; Kim, EJ; Kim, HJ; Kim, YJ; Lee, J; Lee, JS; Lee, KH; Na, DL; Ong, YT; Seo, SW; Wong, TY | 1 |
| Buckley, RF; Chhatwal, JP; Donohue, MC; Johnson, KA; Lois, C; Mormino, EC; Properzi, MJ; Schultz, AP; Sperling, RA | 1 |
| Gunter, JL; Jack, CR; Knopman, DS; Lowe, VJ; Petersen, RC; Schwarz, CG; Senjem, ML; Vemuri, P; Weigand, S | 1 |
| Bateman, RJ; Benzinger, TLS; Berge, G; Bråthen, G; Bu, G; Fagan, A; Grøntvedt, GR; Karch, CM; Lauridsen, C; Morris, JC; Møller, I; Nielsen, HM; Nordberg, A; Patra, K; Rodriguez-Vieitez, E; Sando, SB; Twohig, D; White, LR | 1 |
| Arbizu, J; Boada, M; Martínez-Lage, P; Monleón, I; Munuera, J; Pérez-Grijalba, V; Pesini, P; Romero, J; Ruiz, A; San-José, I; Sarasa, L; Sarasa, M; Tárraga, L | 1 |
| Cipriano, LE; Hachinski, V; Lee, SAW; Ruiz Vargas, E; Sposato, LA | 1 |
| Boeve, BF; Botha, H; Clark, HM; Duffy, JR; Ertekin-Taner, N; Graff-Radford, J; Jack, CR; Jones, DT; Josephs, KA; Knopman, DS; Lowe, VJ; Machulda, MM; Martin, PR; Petersen, RC; Schwarz, CG; Senjem, ML; Sintini, I; Utianski, RL; Weigand, SD; Whitwell, JL | 1 |
| Boellaard, R; De Deyn, PP; de Jong, BM; Dierckx, RAJO; Peretti, DE; Reesink, FE; Vállez García, D; van der Goot, T | 1 |
| Amariglio, RE; Becker, JA; Chhatwal, JP; Donovan, NJ; Gatchel, JR; Hanseeuw, BJ; Johnson, KA; Marshall, GA; Muniz, MC; Papp, KV; Rentz, DM; Schultz, AP; Sperling, RA | 1 |
| Candeias, E; Cardoso, SM; Chand, K; Chaves, S; Rajeshwari, R; Santos, MA | 1 |
| Bertoldo, A; Bodini, B; Brooks, DJ; Edison, P; Marchitelli, L; Schubert, JJ; Stankoff, B; Tonietto, M; Turkheimer, FE; Veronese, M | 1 |
| Drubach, DA; Graff-Radford, J; Jack, CR; Josephs, KA; Lowe, VJ; Machulda, MM; Martin, P; Schwarz, CG; Senjem, ML; Spychalla, AJ; Weigand, SD; Whitwell, JL | 1 |
| Bogie, J; Chintapakorn, Y; Cuypers, A; Dewachter, I; Groen, A; Hellings, N; Hendriks, J; Hoeks, C; Jonker, JW; Kerksiek, A; Leijten, F; Liu, HB; Lütjohann, D; Martinez-Martinez, P; Mulder, M; Pornpakakul, S; Schepers, M; Sijbrands, E; Staels, B; Struik, D; Suttiyut, T; Tiane, A; Vanmierlo, T; Walter, J | 1 |
| Chen, J; Fan, L; Guan, XW; Li, J; Lu, J; Lv, JL; Mao, F; Qiu, XX; Ren, J; Shen, X; Wang, JY; Ye, JM; Zhao, YH; Zhu, J; Zhu, ZY | 1 |
| Scheltens, P; Teunissen, CE; Tijms, BM; van Paasen, AJL; Vermunt, L; Visser, PJ | 1 |
| Bunai, T; Kakimoto, A; Ouchi, Y; Terada, T; Yoshikawa, E | 1 |
| Bocti, C; Chertkow, H; Joannette, M; Joubert, S; Lavallée, MM; Nikelski, J; Rahayel, S; Sévigny Dupont, P | 1 |
| Das, RD; Nivsarkar, M; Panchal, NB; Sagar, SR; Singh, DP; Sudarsanam, V; Vasu, KK | 1 |
| Albertson, SM; Boeve, B; Dickson, DW; Jack, CR; Jones, DT; Kantarci, K; Knopman, D; Lowe, VJ; Lundt, ES; Murray, ME; Parisi, JE; Petersen, RC; Przybelski, SA; Senjem, ML | 1 |
| Baker, SL; Harrison, TM; Helfrich, RF; Jagust, WJ; Knight, RT; Maass, A; Mander, BA; Walker, MP; Winer, JR | 1 |
| Diehl-Schmid, J; Förstl, H; Goldhardt, O; Grimmer, T; Kurz, A; Miners, S; Ortner, M; Perneczky, R; Sorg, C; Yakushev, I | 1 |
| Barkhof, F; Dicks, E; Groot, C; Ossenkoppele, R; Scheltens, P; Twisk, J; van der Flier, WM; van Loenhoud, AC; Wink, AM | 1 |
| Bowie, CR; Brown, EE; Caravaggio, F; Fischer, CE; Flint, A; Gerretsen, P; Graff-Guerrero, A; Herrmann, N; Mah, L; Mulsant, BH; Pollock, BG; Rajji, TK; Rashidi-Ranjbar, N; Voineskos, AN | 1 |
| Hansson, O; Insel, PS; Lim, YY; Mackin, RS; Maruff, PT; Masters, CL; Mattsson, N; Mormino, E; Palmqvist, S; Stomrud, E; Weiner, M | 1 |
| Annus, T; Fryer, TD; Holland, AJ; Hong, YT; Nestor, PJ; Vatansever, D; Williams, GB; Wilson, LR; Zaman, SH | 1 |
| Bateman, RJ; Benzinger, TL; Chatterjee, P; Chhatwal, JP; Fagan, AM; Gardener, SL; Greenberg, SM; Gurol, ME; Johnson, K; Kloet, RW; Martins, R; Morris, JC; Moursel, LG; Schultz, AP; Sohrabi, HR; Sperling, R; Taddei, K; van Berckel, BNM; van Buchem, MA; van der Weerd, L; van Rooden, S; Wermer, MJH; Yaqub, M | 1 |
| Debnath, ML; Klunk, WE; Lin, KS; Mason, NS; Mathis, CA; Pan, J | 1 |
| Klunk, WE; Lingler, JH | 1 |
| Brickman, AM; Griffith, EY; Guzman, VA; Meier, IB; Muraskin, J; Narkhede, A; Provenzano, FA; Tosto, G; Wasserman, BT; Zimmerman, ME | 1 |
| Auriel, E; Ayres, AM; Becker, A; Carmasin, J; Dumas, A; Gidicsin, C; Greenberg, SM; Gurol, ME; Hedden, T; Johnson, KA; Martinez-Ramirez, S; Rosand, J; Schwab, K; van Etten, E; Vashkevich, A; Viswanathan, A | 1 |
| Orvig, C; Patrick, BO; Rodríguez-Rodríguez, C; Telpoukhovskaia, MA | 1 |
| Cho, H; Choe, YS; Ewers, M; Kim, C; Kim, CH; Kim, GH; Kim, HJ; Kim, JS; Kim, ST; Kwak, KC; Lee, JH; Lee, JM; Lee, JW; Lee, KH; Na, DL; Noh, HJ; Noh, Y; Oh, SJ; Park, JH; Seo, SW; Shin, JS; Weiner, MW; Werring, DJ; Yoon, CW; Yoon, U | 1 |
| Chin, J; Cho, H; Choe, YS; Kim, GH; Kim, HJ; Kim, JH; Kim, JS; Lee, JH; Lee, KH; Na, DL; Noh, Y; Seo, SW; Suh, MK; Ye, BS; Yoon, CW | 1 |
| Jagust, WJ; Landau, SM; Madison, CM; Oh, H; Rabinovici, GD; Wirth, M | 1 |
| Aisen, PS; Foroud, T; Inlow, M; Jagust, WJ; Kim, S; Koeppe, RA; Mathis, CA; Petersen, RC; Risacher, SL; Saykin, AJ; Shaw, LM; Shen, L; Soares, H; Swaminathan, S; Trojanowski, JQ; Weiner, MW; West, JD; Yoder, KK | 1 |
| Ames, D; Ashwood, T; Bush, A; Darby, D; Ellis, KA; Harrington, K; Jaeger, J; Lachovitzki, R; Lim, YY; Martins, RN; Maruff, P; Masters, CL; Rowe, CC; Stöffler, A; Szoeke, C; Villemagne, VL | 1 |
| Cinar, Y; Dornieden, S; Funke, SA; Jiang, N; Korth, C; Müller-Schiffmann, A; Sticht, H; Willbold, D; Wördehoff, M | 1 |
| Bao, L; Dong, H; Feng, X; Gao, Q; Gao, Y; Hao, J; Liang, N; Liu, H; Peng, L; Sun, J; Yu, X; Yue, Q; Zhang, J; Zhu, D | 1 |
| Czisch, M; Drzezga, A; Grünecker, B; Henriksen, G; von Reutern, B; Yousefi, BH | 1 |
| Burrell, JR; Hodges, JR; Hornberger, M; Rowe, CC; Villemagne, VL | 1 |
| Ames, D; Bedo, J; Burnham, SC; Bush, AI; Doecke, JD; Ellis, KA; Faux, NG; Head, R; Jones, G; Kiiveri, H; Laws, SM; Macaulay, SL; Martins, RN; Masters, CL; Rembach, A; Rowe, CC; Salvado, O; Villemagne, VL; Wilson, W | 1 |
| Rowe, CC; Villemagne, VL | 2 |
| Kawai, N; Kawanishi, M; Kudomi, N; Maeda, Y; Nishiyama, Y; Tamiya, T; Yamamoto, Y | 1 |
| Gu, L; Guo, Z; Liu, C | 1 |
| Chertkow, H; Ducharme, S; Guiot, MC; Nikelski, J | 1 |
| Bennett, DA; Bradshaw, EM; Chibnik, LB; De Jager, PL; Evans, DA; Imboywa, S; Johnson, K; Keenan, BT; Lee, M; Morris, MC; Ottoboni, L; Raj, T; Rosenkrantz, LL; Schneider, JA; Sperling, RA; Tang, A; Von Korff, A | 1 |
| Kapurniotu, A; Velkova, A; Yan, LM | 1 |
| Cornwell, ME; Cuny, GD; Hernandez, I; Kosik, KS; Laha, JK; Mair, W; Rei, D; Steen, JA; Tsai, LH; Zhang, X | 1 |
| Lilja, J; Lötjönen, J; Lundqvist, R; Rowe, CC; Thomas, BA; Thurfjell, L; Villemagne, VL | 1 |
| Bergfors, A; Gillberg, PG; Marutle, A; Ni, R; Nordberg, A | 1 |
| Aeinehband, S; Almkvist, O; Darreh-Shori, T; Ekdahl, KN; Långström, B; Lindblom, RP; Nilsson, B; Nordberg, A; Piehl, F; Vijayaraghavan, S | 1 |
| Cho, H; Choe, YS; Choi, YS; Jeon, S; Kang, DR; Ki, CS; Kim, C; Kim, GH; Kim, HJ; Kim, JH; Kim, JS; Kim, ST; Lee, JH; Lee, JM; Lee, KH; Na, DL; Noh, Y; Seo, SW; Weiner, MW; Werring, DJ; Ye, BS; Yoon, CW | 1 |
| Ames, D; Bourgeat, P; Bush, AI; Darby, D; Ellis, KA; Harrington, KD; Laws, SM; Lim, YY; Martins, RN; Maruff, P; Masters, CL; Nathan, PJ; Pietrzak, RH; Rowe, CC; Salvado, O; Snyder, PJ; Villemagne, VL | 1 |
| Corona, W; Innis, RB; Jenko, KJ; Kimura, N; Kreisl, WC; Lyoo, CH; McGwier, M; McMahon, FJ; Morse, CL; Pike, VW; Snow, J; Turner, RS; Zoghbi, SS | 1 |
| Hatashita, S; Yamasaki, H | 1 |
| Becker, A; Johnson, KA; Sabuncu, MR; Sepulcre, J; Sperling, R | 1 |
| Benzinger, TL; Buckles, VD; Fagan, AM; Grant, EA; Hollingsworth, H; Morris, JC; Roe, CM; Stark, SL | 1 |
| Eidelberg, D; Martin, W | 1 |
| Cairns, NJ; Campbell, MC; Flores, H; Goate, AM; Hartlein, JM; Markham, J; Perlmutter, JS; Videen, TO | 1 |
| Georgopoulos, S; Klinakis, A; Paouri, E; Sesele, K; Thanopoulou, K; Tsefou, E | 1 |
| Forloni, G; Haaparanta-Solin, M; López-Picón, FR; Rinne, JO; Rokka, J; Salmona, M; Scheinin, M; Snellman, A; Solin, O | 1 |
| Ishikawa, M; Itsukage, M; Kondo, M; Kuriyama, N; Matsushima, S; Nakagawa, M; Nakanishi, H; Tokuda, T; Yamada, K | 1 |
| Frost, AL; Itzhaki, RF; Wozniak, MA | 1 |
| Bergfors, A; Gillberg, PG; Marutle, A; Nennesmo, I; Ni, R; Nordberg, A; Voytenko, L; Yu, W | 1 |
| Huo, YR; Ji, Y; Liu, M; Liu, S; Shi, Z; Wang, J; Wisniewski, T | 1 |
| Dolan, H; Egan, J; Ferrucci, L; Jeffrey Metter, E; Marano, C; O'Brien, RJ; Resnick, SM; Thambisetty, M; Troncoso, JC; Wong, DF; Yang, A; Zhou, Y; Zonderman, AB | 1 |
| Brooks, DJ; Edison, P; Ikoma, Y; Ramlackhansingh, A; Turkheimer, FE | 1 |
| Boellaard, R; Foster-Dingley, JC; Lammertsma, AA; Ossenkoppele, R; Scheltens, P; Tolboom, N; van Berckel, BN; Windhorst, AD; Yaqub, M | 1 |
| Case, M; Hake, A; Hochstetler, H; Schuh, K; Sun, J; Trzepacz, PT; Witte, MM; Yu, P | 1 |
| Coppola, G; Ghosh, PM; Huang, Y; Jagust, WJ; Karydas, A; Lehmann, M; Madison, C; Miller, BL; O'Neil, JP; Rabinovici, GD | 1 |
| Aoki, I; Chang, Q; Furumoto, S; Higuchi, M; Ito, H; Iwata, N; Jang, MK; Ji, B; Kudo, Y; Lee, VM; Lewis, J; Maeda, J; Maruyama, M; Masamoto, K; Okamura, N; Ono, M; Sahara, N; Saido, TC; Shimada, H; Shinotoh, H; Suhara, T; Takano, H; Takashima, A; Trojanowski, JQ; Zhang, MR | 1 |
| Johansson, J; Karrasch, M; Kemppainen, NM; Koivunen, J; Någren, K; Parkkola, R; Rinne, JO; Rokka, J; Scheinin, NM; Toivonen, JT | 1 |
| Chin, J; Cho, H; Choe, YS; Jang, EY; Jeon, S; Kim, CH; Kim, GH; Kim, HJ; Kim, JH; Lee, J; Lee, JM; Lee, KH; Na, DL; Noh, Y; Seo, SW; Seong, JK; Ye, BS; Yoon, CW | 1 |
| Hatashita, S; Hayakawa, H; Suzuki, Y; Tanaka, K; Wakebe, D; Yamasaki, H | 1 |
| Frings, L; Hüll, M; Meyer, PT; Spehl, TS; Weber, WA | 1 |
| Arlicot, N; Beaufils, E; Camus, V; Chalon, S; Corcia, P; Gosselin, T; Guilloteau, D; Hommet, C; Minier, F; Mondon, K; Paccalin, M; Page, G; Ribeiro, MJ | 1 |
| Haase, CM; Jagust, WJ; Landau, SM; Madison, CM; Oh, H; Rabinovici, GD; Villeneuve, S; Wirth, M | 1 |
| Ahmad, R; Bormans, G; Cleeren, E; De Winter, FL; Goffin, K; Persoons, P; Tournoy, J; Van den Stock, J; Van Laere, K; Vandenbulcke, M | 1 |
| Aisen, PS; Aldea, P; Ances, BM; Bateman, RJ; Benzinger, TL; Blazey, T; Brickman, A; Buckles, VD; Cairns, NJ; Cash, DM; Christensen, JJ; Correia, S; Ercole, L; Fagan, AM; Farrar, AM; Fox, NC; Ghetti, B; Goate, A; Holtzman, DM; Hornbeck, RC; Jack, CR; Jasielec, MS; Johnson, KA; Klunk, W; Koeppe, RA; Marcus, DS; Martins, R; Masters, CL; Mathis, CA; Mayeux, R; McDade, E; Morris, JC; Moulder, K; Ourselin, S; Owen, CJ; Raichle, ME; Ringman, J; Rossor, MN; Rowe, C; Salloway, S; Saykin, AJ; Schofield, PR; Snyder, AZ; Sperling, RA; Su, Y; Thompson, PM; Villemagne, VL; Weiner, MW; Xie, X; Xiong, C | 1 |
| Huang, Z; Jiang, J; Lin, X; Wen, J; Yan, Z | 1 |
| Darreh-Shori, T; Hosseini, SM; Nordberg, A | 1 |
| Benzinger, TL; Blazey, TM; Christensen, JJ; D'Angelo, GM; Marcus, DS; Mintun, MA; Morris, JC; Snyder, AZ; Su, Y; Vlassenko, AG; Vora, S; Zhou, G | 1 |
| Arakawa, R; Eguchi, Y; Fukumura, T; Higuchi, M; Ito, H; Kodaka, F; Miyoshi, M; Okamura, N; Ono, M; Shimada, H; Shinotoh, H; Suhara, T; Takahashi, H; Takano, H; Yanai, K | 1 |
| Antoni, G; Estrada, S; Hellström-Lindahl, E; Westermark, P | 1 |
| Duffy, JR; Jack, CR; Josephs, KA; Jung, Y; Lowe, V; Machulda, MM; Senjem, ML; Strand, EA; Whitwell, JL | 1 |
| Ames, D; Burnham, SC; Bush, AI; Doecke, JD; Ellis, KA; Macaulay, SL; Martins, RN; Maruff, P; Masters, CL; Rembach, A; Rowe, CC; Villemagne, VL; Watt, AD; Wilson, WJ | 1 |
| Boxer, AL; Gesierich, B; Ghosh, PM; Gorno-Tempini, M; Grinberg, LT; Hagen, J; Henry, M; Huang, EJ; Jagust, WJ; Janabi, M; Kramer, JH; Miller, BL; O'Neil, JP; Rabinovici, GD; Rosen, HJ; Sánchez-Juan, P; Seeley, WW; Trojanowski, JQ; Vinters, HV | 1 |
| Miličević, A; Raos, N | 1 |
| Arai, A; Arai, H; Furukawa, K; Furumoto, S; Iwata, R; Kaneta, T; Kudo, Y; Okamura, N; Takahashi, S; Takanami, K; Tashiro, M; Yanai, K | 1 |
| Alvarez-Retuerto, AI; Benzinger, T; Chakraverty, S; Coppola, G; Fagan, A; Goate, A; Hecimovic, S; Kepe, V; Porter, V; Ringman, JM; Ting, SK | 1 |
| Ames, D; Bourgeat, P; Dore, V; Ellis, KA; Fripp, J; Macaulay, SL; Masters, CL; Raniga, P; Rowe, CC; Salvado, O; Villemagne, VL; Zhou, L | 1 |
| Chen, J; Cheng, XX; Shi, JQ; Xu, J; Zhang, QQ; Zhu, HQ | 1 |
| Byun, MS; Choe, YM; Lee, DY; Seo, EH; Sohn, BK; Woo, JI; Yi, D | 1 |
| Doré, V; Fodero-Tavoletti, MT; Furumoto, S; Harada, R; Hodges, J; Kudo, Y; Masters, CL; Mulligan, RS; Okamura, N; Pejoska, S; Piguet, O; Rowe, CC; Villemagne, VL; Yanai, K; Yates, P | 1 |
| Abrahamson, EE; He, B; Ikonomovic, MD; Mufson, EJ; Nadeem, M; Perez, SE; Scheff, SW; Wuu, J | 1 |
| Ames, D; Darby, D; Ellis, KA; Harrington, K; Lim, YY; Martins, RN; Maruff, P; Masters, CL; Pietrzak, RH; Rowe, CC; Savage, G; Szoeke, C; Villemagne, VL | 1 |
| Alexopoulos, P; Drzezga, A; Förster, S; Förstl, H; Goldhardt, O; Grimmer, T; Guo, LH; Kurz, A; Perneczky, R; Sorg, C; Yousefi, BH | 1 |
| Chen, X; Li, M; Liu, X; Wang, S; Xiong, Y; Zhu, H | 1 |
| Alexopoulos, P; Auer, F; Diehl-Schmid, J; Drzezga, A; Förster, S; Förstl, H; Grimmer, T; Kurz, A; Ortner, M; Perneczky, R; Sorg, C; Yousefi, BH | 1 |
| Adriaanse, SM; Barkhof, F; Boellaard, R; Lammertsma, AA; Ossenkoppele, R; Reuter, M; Scheltens, P; Tolboom, N; van Berckel, BN; van der Flier, WM; van Dijk, KR; Windhorst, AD; Yaqub, M; Zwan, MD | 1 |
| Ames, D; Desmond, PM; Ellis, KA; Martins, RN; Masters, CL; Phal, PM; Rowe, CC; Salvado, O; Steward, C; Szoeke, C; Villemagne, VL; Yates, PA | 1 |
| Fodero-Tavoletti, MT; Furumoto, S; Harada, R; Kudo, Y; Masters, CL; Mulligan, RS; Okamura, N; Pejoska, S; Rowe, CC; Villemagne, VL; Yanai, K; Yates, P | 1 |
| Cheng, L; El Fakhri, G; Hu, C; Lu, YM; Sepulcre, J | 1 |
| Adriaanse, S; Bouwman, F; Lammertsma, A; Ossenkoppele, R; Scheltens, P; Teunissen, C; van Berckel, B; van der Flier, W; van Harten, A; Zwan, M | 1 |
| Drzezga, A; Förster, S; Förstl, H; Göttler, J; Grimmer, T; Koch, K; Kurz, A; Mühlau, M; Myers, N; Neitzel, J; Ortner, M; Pasquini, L; Riedl, V; Sorg, C; Wohlschläger, AM; Zimmer, C | 1 |
| Ghosh, P; Jagust, WJ; Laforce, R; Lehmann, M; Madison, CM; Miller, BL; Rabinovici, GD; Tosun, D; Weiner, MW | 1 |
| Cohen, AD; Klunk, WE | 1 |
| Drzezga, A; Förster, S; Grimmer, T; Klupp, E; Sorg, C; Tahmasian, M; Yakushev, I; Yousefi, BH | 1 |
| Ishibashi, K; Ishii, K; Ishiwata, K; Miura, Y; Oda, K | 1 |
| Chui, HC; DeCarli, C; Jagust, WJ; Kriger, S; Mack, WJ; Madison, CM; Marchant, NL; Reed, BR; Sanossian, N; Villeneuve, S; Weiner, MW; Wirth, M | 1 |
| Ames, D; Bush, AI; Doecke, JD; Ellis, KA; Macaulay, SL; Martins, RN; Masters, CL; Rainey-Smith, S; Rembach, A; Rowe, CC; Villemagne, VL; Watt, AD; Wilson, WJ | 1 |
| Gauthier, S; Heurling, K; Leuzy, A; Rosa-Neto, P; Zimmer, ER | 1 |
| Hermann, DM | 1 |
| Hirano, H; Kajiya, Y; Tani, A; Yokoyama, S; Yoshinaga, T | 1 |
| Chen, J; LeVine, H; Matveev, SV; Metts, BM; Onono, F; Scheff, SW; Spielmann, HP; Walker, LC; Zhu, H | 1 |
| Drzezga, A; Förster, S; Förstl, H; Göttler, J; Grimmer, T; Koch, K; Kurz, A; Manoliu, A; Myers, NE; Neitzel, J; Pasquini, L; Riedl, V; Sorg, C; Wohlschläger, AM | 1 |
| Feng, J; Hyde, C; McShane, R; Noel-Storr, AH; Smailagic, N; Takwoingi, Y; Zhang, S | 1 |
| Chen, TF; Cheng, TW; Chiu, MJ; Horng, HE; Huang, YY; Shiue, CY; Tzen, KY; Wen, HP; Yang, SY | 1 |
| Fan, Y; Fu, L; Liu, L; Tian, J; Xu, B; Zhang, J | 1 |
| Fitzgerald, S; Lauer, SL; Levy, E; Lopez-Guzman, M; Nixon, RA; Schoen, C; Wilson, DA; Xu, W | 1 |
| Gunter, JL; Jack, CR; Knopman, DS; Lowe, VJ; Mielke, MM; Pankratz, VS; Petersen, RC; Preboske, GM; Rocca, WA; Senjem, ML; Vemuri, P; Weigand, SD; Wiste, HJ | 1 |
| Bartic, C; Benilova, I; Castillo Cano, V; De Strooper, B; Gallardo, R; Ramakers, M; Rousseau, F; Schymkowitz, J; Snellinx, A; Ungureanu, AA | 1 |
| Ames, D; Bourgeat, P; Brown, B; Dore, V; Ellis, K; Fripp, J; Macaulay, SL; Martins, R; Masters, CL; Rowe, CC; Salvado, O; Villemagne, VL | 1 |
| Ashraf, A; Brooks, DJ; Edison, P; Fan, Z | 1 |
| Hosokawa, C; Hosono, M; Hyodo, T; Ishii, K; Murakami, T; Sakaguchi, K; Shimamoto, K; Usami, K; Yamazoe, Y | 1 |
| Chen, L; Jia, L; Ren, J; Wang, C; Xie, J; Xu, L | 1 |
| Ames, D; Ellis, KA; Harrington, K; Laws, SM; Lim, YY; Martins, RN; Maruff, P; Masters, CL; Pietrzak, RH; Rembach, A; Rowe, CC; Snyder, PJ; Villemagne, VL | 1 |
| Asthana, S; Bendlin, BB; Carlsson, CM; Christian, BT; Cook, D; Dowling, NM; Edwards, D; Gallagher, CL; Hermann, BP; Johnson, SC; Koscik, R; Larson, J; LaRue, A; Oh, JM; Okonkwo, OC; Rowley, HA; Sager, MA; Schultz, SA | 1 |
| Arai, A; Arai, H; Fukuda, H; Iwata, R; Kaneta, T; Kudo, Y; Okamura, N; Takahashi, S; Takanami, K; Tashiro, M; Yanai, K | 1 |
| Alí-Torres, J; Bailey, GA; Hidalgo, J; Manso, Y; Orvig, C; Rodríguez-Rodríguez, C; Rodríguez-Santiago, L; Sodupe, M; Telpoukhovskaia, MA | 1 |
| Airoldi, C; Cabrita, EJ; de Almeida, RF; Dias, C; Jesus, AR; Jiménez-Barbero, J; Macedo, MP; Marcelo, F; Martins, A; Matos, AM; Nicotra, F; Rauter, AP; Ribeiro, RT; Viana, AS | 1 |
| Han, B; He, W; Li, G; Liu, D; Radua, J; Sun, Z | 1 |
| Elmaleh, DR; Li, Y; Moore, A; Ran, C; Shoup, TM; Teng, X; Tian, Y; Zhang, X | 1 |
| Hanada, K; Hosokawa, C; Hosono, M; Hyodo, T; Ishii, K; Murakami, T; Saigo, K; Sakaguchi, K; Shimamoto, K; Ueda, M; Usami, K; Yamazoe, Y | 1 |
| Cho, H; Choe, YS; Im, K; Kim, HJ; Kim, JS; Kim, ST; Kim, YJ; Kwon, H; Lee, JH; Lee, JM; Lee, KH; Na, DL; Seo, SW; Ye, BS | 1 |
| Baker, SL; Crowley, S; Elman, JA; Jagust, WJ; Madison, CM; Marks, SM; O'Neil, JP; Vogel, JW | 1 |
| Benzinger, TL; Devous, MD; Jagust, WJ; Johnson, KA; Klunk, WE; Koeppe, RA; Mathis, CA; Minhas, D; Mintun, MA; Pontecorvo, MJ; Price, JC; Rowe, CC; Skovronsky, DM | 1 |
| Cho, H; Choe, YS; Hwang, JW; Jeong, JH; Kim, GH; Kim, HJ; Kim, JH; Kim, JS; Kim, ST; Lee, JH; Lee, KH; Na, DL; Noh, Y; Oh, SJ; Seo, SW; Seong, JK; Ye, BS; Yoon, CW | 1 |
| Curtis, MA; Dragunow, M; Faull, R; Lill, C; Narayan, PJ | 1 |
| Aldea, P; Ances, BM; Bateman, RJ; Benzinger, TLS; Blazey, TM; Brickman, AM; Buckles, V; Cairns, NJ; Cash, L; Christensen, JJ; Farrar, AM; Friedrichsen, K; Ghetti, B; Hornbeck, RC; Johnson, KA; Klunk, W; Marcus, DS; Mayeux, R; Morris, JC; Owen, CJ; Price, JC; Raichle, ME; Saykin, AJ; Schofield, PR; Snyder, AZ; Sperling, RA; Su, Y; Thompson, PM | 1 |
| Corby, P; Craig, RG; de Leon, MJ; Glodzik, L; Kamer, AR; Linker, R; McHugh, P; Mosconi, L; Pirraglia, E; Rusinek, H; Saxena, D; Shi, C; Svetcov, S; Tsui, W; Vallabhajosula, S; Williams, S; Yi, L | 1 |
| Almkvist, O; Kadir, A; Nordberg, A | 1 |
| Caine, JM; Macreadie, IG; Porzoor, A | 1 |
| Al-Soufi, W; Freire, S; Novo, M; Penedo, JC; Ríos Rodríguez, MC; Rodríguez-Prieto, F | 1 |
| Donovan, LJ; Landreth, GE; Malm, T; Mariani, M; Neilson, L | 1 |
| Gunter, JL; Jack, CR; Kantarci, K; Knopman, DS; Lesnick, TG; Lowe, VJ; Machulda, MM; Mielke, MM; Petersen, RC; Preboske, GM; Przybelski, SA; Raman, MR; Roberts, RO; Rocca, WA; Senjem, ML; Vemuri, P | 1 |
| Jung, NY; Kim, HJ; Kim, ST; Kim, YJ; Kwon, HK; Lee, JM; Lee, KH; Na, DL; Seo, SW | 1 |
| Apostolova, LG; Avila, D; Elashoff, D; Hwang, KS; Jack, CR; Jagust, WJ; Kohannim, O; Shaw, L; Sokolow, S; Teng, E; Thompson, PM; Trojanowski, JQ; Weiner, MW | 1 |
| Govindaraju, T; Manjithaya, R; Rajasekhar, K; Suresh, SN | 1 |
| Almkvist, O; Carter, SF; Chiotis, K; Leuzy, A; Nordberg, A; Wall, A | 1 |
| Drubach, DA; Duffy, JR; Gunter, JL; Jack, CR; Josephs, KA; Kantarci, K; Lowe, VJ; Lundt, ES; Machulda, MM; Petersen, RC; Spychalla, AJ; Strand, EA; Weigand, SD; Whitwell, JL | 1 |
| Bateman, RJ; Benzinger, T; Bourgeat, P; Brown, BM; Chatterjee, P; Dhaliwal, S; Fagan, AM; Gupta, VB; Jasielec, MS; Martins, RN; Morris, JC; Sohrabi, HR; Taddei, K; Xiong, C | 1 |
| Amariglio, RE; Dagley, AS; Donovan, NJ; Hsu, DC; Johnson, KA; Marshall, GA; Mormino, EC; Okereke, OI; Rentz, DM; Schultz, AP; Sperling, RA | 1 |
| Adlard, PA; Barnham, KJ; Curtain, CC; Doble, PA; Hare, DJ; Hinds, MG; Kirby, N; Li, QX; Lind, M; Masters, CL; McColl, G; Mertens, HD; Pham, CL; Roberts, AM; Roberts, BR; Ryan, TM | 1 |
| Langlois, X; Schmidt, M; Staelens, S; Stroobants, S; Van Der Linden, A; Verhaeghe, J; Waldron, AM; wyffels, L | 1 |
| Dias, DM; Geraldes, CF; Lacerda, S; Laurents, DV; Martins, AF; Morfin, JF; Tóth, É | 1 |
| Ambure, P; Roy, K | 1 |
| Bai, F; Beebe, DC; Bei, L; Nelson, SK; Shui, YB; Van Stavern, GP | 1 |
| Arai, H; Funaki, Y; Furukawa, K; Furumoto, S; Harada, R; Hiraoka, K; Inami, A; Ishikawa, Y; Ishiki, A; Iwata, R; Kudo, Y; Matsuda, R; Miyake, M; Okamura, N; Shidahara, M; Tago, T; Tashiro, M; Tomita, N; Watanuki, S; Yanai, K; Yoshikawa, T | 1 |
| Cannon, A; Dickson, DW; Duara, R; Graff-Radford, NR; Jack, CR; Kantarci, K; Knopman, DS; Liesinger, AM; Lowe, VJ; Murray, ME; Parisi, JE; Petersen, RC; Przybelski, SA; Rawal, B; Ross, OA | 1 |
| Alejandra, A; Claudio, W; Federico, N; Gabriela, C; Griselda, R; Gustavo, S; Janus, K; Jorge, C; Julieta, RM; Leonardo, T; Marcos, FS; Patricio, CM; Ramon, L; Ricardo, A; Salvador, G; Santiago, P; Silvia, V | 1 |
| Baker, D; Bazenet, C; Burnham, SC; Covin, A; Dobson, RJ; Kiddle, S; Lovestone, S; Sangurdekar, DP; Tan Hehir, CA; Voyle, N; Zhang, Z | 1 |
| Kim, J; Lee, JM; Park, H; Seo, J; Son, SJ | 1 |
| Baker, SL; Boutchko, R; Gullberg, GT; Jagust, WJ; Mitra, D | 1 |
| Goduni, E; Jay, T; Lamb, BT; Landreth, GE; Malm, T; Mariani, MM; Quigley, C; Ransohoff, RM; Savage, JC | 1 |
| Campos, C; Gil, P; Guzmán, R; Masegù, C; Moragón, ÁC; Yuguero, R | 1 |
| Claassen, DO; Ding, Z; Kang, H; Mckay, JW; Riddle, WR; Rogers, BP; Shokouhi, S | 1 |
| Arthur-Bentil, SK; Ayakta, N; Borys, E; Boxer, AL; Cohn-Sheehy, BI; DeCarli, C; Ghosh, PM; Grinberg, LT; Huang, EJ; Jagust, W; Jin, LW; La Joie, R; Lehmann, M; Madison, C; Marks, SM; Miller, BL; Olichney, J; Rabinovici, GD; Reed, B; Rosen, HJ; Seeley, WW; Villeneuve, S; Vogel, JW | 1 |
| Abad, S; Auladell, C; Beas-Zarate, C; Camins, A; Ettcheto, M; Folch, J; Lazarowski, A; Marin, M; Olloquequi, J; Pedrós, I; Petrov, D | 1 |
| Albert, MS; An, Y; Bilgel, M; Cai, Q; Ferrucci, L; Moghekar, A; O'Brien, RJ; Prince, JL; Resnick, SM; Soldan, A; Thambisetty, M; Wang, MC; Wong, DF; Zhou, Y | 1 |
| Chen, YX; Li, YM; Liu, Q; Qiu, T; Zhao, YF | 1 |
| Cheng, L; Fakhri, GE; Hu, C; Johnson, KA; Li, Q; Lu, YM; Sepulcre, J | 1 |
| Hwang, J; Kim, CM; Koh, JY; Lee, JH; Lee, JM; Roh, JH | 1 |
| Chen, YJ; Klunk, WE; Laymon, CM; Lopez, OL; Lopresti, BJ; Lu, X; Mathis, CA; Mowrey, W; Price, JC; Rosario, BL | 1 |
| Asthana, S; Benca, RM; Bendlin, BB; Christian, BT; Johnson, SC; Koscik, RL; Okonkwo, OC; Racine, AM; Sager, MA; Sprecher, KE | 1 |
| Arima, K; Ito, K; Matsuda, H; Motohashi, N; Nakagome, K; Nakata, Y; Omachi, Y; Sakata, M; Sato, N | 1 |
| Viles, JH; Younan, ND | 1 |
| Fan, Y; Fu, L; Liu, L; Tian, J; Xu, B; Zhang, J; Zhang, X | 1 |
| Arai, H; Baba, T; Furukawa, K; Furumoto, S; Hiraoka, K; Iizuka, O; Iwata, R; Kanno, S; Kikuchi, H; Mori, E; Narita, W; Okamura, N; Tashiro, M; Yanai, K | 1 |
| Di Carlo, MG; Foderà, V; Leone, M; Militello, V; Minicozzi, V; Morante, S; Vetri, V | 1 |
| Benzinger, TL; Gordon, BA; Hsu, P; Morris, JC; Najmi, S; Roe, CM | 1 |
| Carter, SF; Chiotis, K; Farid, K; Nordberg, A; Savitcheva, I | 1 |
| Li, M; Qu, X; Ren, J; Zhao, C | 1 |
| Aizenstein, HJ; Gianaros, PJ; Ikonomovic, S; James, JA; Klunk, WE; Lopez, OL; Mathis, CA; McDade, EM; Minhas, D; Mowrey, W; Price, JC; Sheu, LK; Snitz, BE; Tudorascu, DL; Weissfeld, L; Yau, WW | 1 |
| Benzinger, TL; Brix, B; Darby, HD; Fagan, AM; Holtzman, DM; Jasielec, MS; Ladenson, JH; Macy, EM; Morris, JC; Shah, AR; Stoops, EE; Sutphen, CL; Vanderstichele, HM; Vandijck, ML; Vlassenko, AG; Xiong, C | 1 |
| Kirby, T | 1 |
| Moir, RD; Moore, A; Ran, C; Ross, AW; Sun, H; Tanzi, RE; Tian, X; Tian, Y; Zhang, C; Zhang, X | 1 |
| Booth, K; Brashear, HR; Broome, S; Collins, P; Di, J; Fox, NC; Gregg, KM; Grundman, M; Hill, DL; Klunk, WE; Koeppe, R; Les, AS; Liu, E; Lu, Y; Margolin, R; Mason, NS; Mathis, CA; Salloway, S; Schmidt, ME; Sperling, R; Tudor, IC; Wyman, BT; Yuen, E | 1 |
| Cantlon, A; Cao, KJ; Elbel, K; Guan, Y; Shah, JV; Theodorakis, EA; Walsh, DM; Yang, J | 1 |
| Byun, MS; Choe, YM; Choi, HJ; Lee, DY; Lee, JM; Seo, EH; Sohn, BK; Woo, JI; Yi, D | 1 |
| Basile, L; Gazioglu, I; Ginex, T; Guccione, S; Kucukislamoglu, M; Kurt, BZ; Sonmez, F | 1 |
| Apollaro, A; Carpinelli, A; Coliva, A; Gatti, D; Gianolli, L; Gilardi, MC; Monterisi, C; Penso, M; Perani, D | 1 |
| Ågren, H; Kuang, G; Murugan, NA; Nordberg, A; Tu, Y | 1 |
| Coppola, G; Geschwind, DH; Ghosh, PM; Khazenzon, AM; Lee, SE; Miller, BL; Pribadi, M; Rabinovici, GD; Rankin, KP; Sha, SJ | 1 |
| Adachi, T; Hongo, K; Ichino, H; Kawata, Y; Kobayashi, S; Mizobata, T; Nakanishi, M; Nakashima, K; Uchino, K; Watanabe, Y; Yamakawa, MY | 1 |
| Ashino, H; Bando, K; Chen, CJ; Farde, L; Higuchi, M; Ji, B; Kasahara, H; Minamizawa, T; Ono, M; Sano, H; Seki, C; Shiraishi, H; Suhara, T; Yamada, K; Zhang, MR | 1 |
| Ashraf, M; Javed, MT; Khan, F; Khan, KM; Khan, MA; Mirza, S; Rahim, F; Taha, M; Ullah, H; Wadood, A | 1 |
| Hasselbalch, SG | 1 |
| Liu, J; Liu, Z; Yin, F; Zhang, Y | 1 |
| Au, L; Chen, S; Ho, CL; Leung, EY; Liu, W; Mok, VC; Wang, Z; Wong, A; Yang, J | 1 |
| Ames, D; Collins, S; Darby, D; Doecke, JD; Ellis, KA; Evered, LA; Fowler, CJ; Laughton, KM; Laws, SM; Li, QX; Macaulay, SL; Martins, RN; Masters, CL; McGlade, A; Pertile, KK; Rainey-Smith, SR; Rembach, A; Robertson, JS; Rowe, CC; Rumble, RL; Sarros, S; Silbert, B; Taddei, K; Trounson, BO; Varghese, S; Villemagne, VL | 1 |
| Ames, D; Baker, D; Burnham, SC; Ellis, K; Macaulay, SL; Martins, RN; Maruff, P; Masters, CL; Narayan, VA; Novak, G; Raghavan, N; Romano, G; Ropacki, MT; Rowe, CC; Savage, G; Wilson, W | 1 |
| Aschenbrenner, AJ; Balota, DA; Benzinger, TL; Duchek, JM; Fagan, AM; Morris, JC | 1 |
| Boeve, BF; Gunter, JL; Jack, CR; Jones, DT; Kantarci, K; Knopman, DS; Lowe, VJ; Lundt, ES; Machulda, MM; Mielke, MM; Petersen, RC; Roberts, RO; Senjem, ML; Vemuri, P; Weigand, SD; Wiste, HJ | 1 |
| Gao, X; Huang, HL; Shi, S; Wang, L; Wang, LL; Yao, JL; Yao, TM | 1 |
| Apostolova, LG; Drubach, DA; Duffy, JR; Gunter, JL; Jack, CR; Josephs, KA; Kantarci, K; Lowe, VJ; Machulda, MM; Madhavan, A; Petersen, RC; Przybelski, SA; Reid, RI; Schwarz, CG; Senjem, ML; Strand, EA; Whitwell, JL | 1 |
| Albers, M; Alverio, J; Amariglio, R; Becker, JA; Betensky, RA; Chhatwal, J; Dickerson, B; Gomez-Isla, T; Hyman, B; Johnson, KA; Judge, K; Marshall, G; Mauro, S; Mormino, E; Papp, K; Pepin, L; Philiossaint, M; Rentz, D; Schultz, A; Sepulcre, J; Shoup, T; Sperling, R; Vasdev, N; Yokell, D | 1 |
| Brooks, DJ; Edison, P; Fan, Z; Okello, AA | 1 |
| Lahiri, DK; Paule, MG; Ray, B; Raymick, J; Sarkar, S; Schmued, L | 1 |
| Chojnacki, JE; Liu, K; Saathoff, JM; Zhang, S | 1 |
| Almeida, RP; Asthana, S; Bendlin, BB; Blennow, K; Boots, EA; Carlsson, CM; Christian, BT; Dowling, MN; Edwards, DF; Einerson, J; Gallagher, CL; Hermann, BP; Johnson, SC; Korcarz, CE; Koscik, RL; Oh, JM; Okonkwo, OC; Sager, MA; Schultz, SA; Stein, JH; Zetterberg, H | 1 |
| Alexopoulos, P; Drzezga, A; Förster, S; Förstl, H; Goldhardt, O; Grimmer, T; Kurz, A; Ortner, M; Sorg, C; Wutz, C | 1 |
| Amariglio, RE; Dagley, A; Johnson, KA; Mormino, EC; Munro, C; Papp, KV; Rentz, DM; Schultz, AP; Sperling, RA | 1 |
| Aizenstein, HJ; Boudhar, S; Cohen, AD; Klunk, WE; Laymon, CM; Mathis, CA; McDade, E; Mountz, JM; Price, JC; Zhang, Z | 1 |
| Bilkova, Z; Hromadkova, L; Jankovicova, B; Kupcik, R; Ripova, D; Rousar, T | 1 |
| Bayer, S; Gomperts, SN; Growdon, JH; Johnson, KA; Locascio, JJ; Marquie, M | 1 |
| Bottelbergs, A; Kelley, JB; Langlois, X; Schmidt, ME; Staelens, S; Stroobants, S; Waldron, AM; Wintmolders, C | 1 |
| Fosso, MY; Garneau-Tsodikova, S; Head, E; LeVine, H; McCarty, K | 1 |
| Cha, J; Choe, YS; Jung, NY; Kim, HJ; Kim, JS; Kim, ST; Kim, YJ; Lee, JH; Lee, JM; Lee, KH; Na, DL; Seo, SW; Shin, JS | 1 |
| Ihara, M; Iida, H; Kajimoto, K; Kazui, H; Kishimoto, T; Kosaka, J; Kudo, T; Matsuoka, K; Morita, N; Nagatsuka, K; Taguchi, A; Yamamoto, A; Yasuno, F | 1 |
| Bakota, L; Ballatore, C; Brandt, R; Ghori, A; Golovyashkina, N; Niewidok, B; Penazzi, L; Selle, K; Smith, AB; Tackenberg, C | 1 |
| Liu, SX; Sun, ZQ; Tu, LX; Zhuo, FJ | 1 |
| Constantinescu, CC; Liang, C; Mirbolooki, MR; Mukherjee, J; Mukherjee, MT; Pan, ML; Patel, B; Patel, HH | 1 |
| Brown, EE; Chow, TW; Felsky, D; Freedman, M; Graff-Guerrero, A; Houle, S; Ismail, Z; Mizrahi, R; Mulsant, BH; Pollock, BG; Tang-Wai, DF; Verhoeff, NP; Voineskos, AN; Wilson, AA | 1 |
| Ances, BM; Benzinger, TLS; Brier, MR; Friedrichsen, KA; McCarthy, JE; Morris, JC; Stern, A; Su, Y; Vlassenko, AG | 1 |
| Abad, S; Auladell, C; Beas-Zarate, C; Camins, A; Ettcheto, M; Folch, J; García, ML; Olloquequi, J; Petrov, D; Sánchez-López, E | 1 |
| Flanagan, E; Hodges, JR; Hornberger, M; Leyton, CE; Ramanan, S; Rowe, CC; Villemagne, VL | 1 |
| Hodges, JR; Leyton, CE; Piguet, O; Schubert, S | 1 |
| Almkvist, O; Carter, SF; Chiotis, K; Långström, B; Leuzy, A; Nordberg, A; Rodriguez-Vieitez, E; Saint-Aubert, L; Schöll, M; Wall, A | 1 |
| Alves, CB; Ferreira, CF; Ianiski, FR; Luchese, C; Rech, VC; Savegnago, L; Wilhelm, EA | 1 |
| Baker, SL; Faria, J; Jagust, WJ; Janabi, M; Lockhart, SN; O'Neil, JP; Ossenkoppele, R; Rabinovici, GD; Schöll, M; Schonhaut, DR; Schwimmer, HD; Vogel, JW | 1 |
| Ayakta, N; Baker, SL; Bettcher, BM; Cantwell, A; Gorno-Tempini, ML; Jagust, WJ; Janabi, M; Kramer, JH; Lazaris, A; Lockhart, SN; Miller, BL; Miller, ZA; O'Neil, JP; Ossenkoppele, R; Rabinovici, GD; Santos, M; Schöll, M; Schonhaut, DR; Vogel, J; Vossel, KA | 1 |
| Hu, YH; Ren, WM; Tang, XC; Xu, MM; Zhang, HY | 1 |
| Frings, L; Hüll, M; Meyer, PT; Spehl, TS | 1 |
| Cho, CH; Cho, SW; Choi, SY; Kim, EA; Kim, J; Yang, SJ | 1 |
| Crimmins, D; D'Angelo, G; Fagan, AM; Griest, T; Herries, E; Holtzman, DM; Ladenson, JH; Morris, JC; Tarawneh, R; Zipfel, GJ | 1 |
| Barthel, H; Gertz, HJ; Hesse, S; Hoffmann, KT; Luthardt, J; Patt, M; Sabri, O; Schroeter, ML; Tiepolt, S; Weise, D | 1 |
| Ashton, NJ; Baird, AL; Baker, D; Bazenet, C; Cereda, C; Graf, J; Hehir, CT; Hye, A; Khondoker, MR; Kiddle, SJ; Leoni, E; Leung, R; Lovestone, S; Lynham, S; Sainz-Fuertes, R; Thambisetty, M; Ward, M; Westwood, S | 1 |
| Ågren, H; Govindaraju, T; Kuang, G; Murugan, NA; Narayanaswamy, N; Rajasekhar, K | 1 |
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| An, SS; Bagyinszky, E; Chun, IK; Giau, VV; Han, JY; Jang, JW; Kang, SM; Kim, S; Lim, KT; Park, SY; Park, YH; Wang, MJ; Yi, S; Youn, YC | 1 |
| Bailey, KR; Fields, JA; Gleason, C; Jack, CR; Kantarci, K; Lesnick, TG; Lowe, VJ; Mielke, MM; Miller, VM; Rocca, WA; Senjem, ML; Shuster, LT; Tosakulwong, N; Zuk, SM | 1 |
| Cai, L; Dadiboyena, S; Diaz-Arrastia, R; Hurtle, BT; Pike, VW; Qu, B | 1 |
| Baker, S; Jagust, W; Madison, C; Oh, H; Rabinovici, G | 1 |
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| Chu, LW; Ha, J; Lee, SC; Shea, YF | 1 |
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| Amariglio, RE; Donovan, NJ; Hsu, DC; Johnson, KA; Marshall, GA; Mormino, EC; Rentz, DM; Schultz, AP; Sperling, RA | 1 |
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| Bednarikova, Z; Fedunova, D; Gazova, Z; Huy, PD; Li, MS; Mocanu, MM | 1 |
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| Benzinger, TL; Fagan, AM; Gordon, BA; Holtzman, DM; Jasielec, MS; McCue, L; Morris, JC; Su, Y; Vlassenko, AG; Xiong, C | 1 |
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| Fan, HX; Feng, XL; Gao, H; He, RR; Kurihara, H; So, KF; Xiao, J; Yao, XS; Yu, Y; Zhou, ZQ | 1 |
| André, I; Faller, P; Gras, E; Hoarau, M; Hureau, C; Irague, R; Malbert, Y; Remaud-Siméon, M | 1 |
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| Chemuru, S; Kar, K; Kodali, R; Misra, P; Wetzel, R | 1 |
| Benzinger, TL; Blazey, T; Fagan, AM; Gordon, BA; Holtzman, DM; Morris, JC; Su, Y | 1 |
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| Ibaraki, M; Ikoma, Y; Ito, H; Kinoshita, T; Matsubara, K; Shimada, H; Suhara, T | 1 |
| Antoni, G; Arvidsson, S; Lindqvist, P; Pilebro, B; Sörensen, J; Suhr, O; Sundström, T; Westermark, P | 1 |
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| Asthana, S; Bendlin, BB; Blennow, K; Carlsson, CM; Christian, BT; Darst, BF; Engelman, CD; Hermann, BP; Hogan, KJ; Johnson, SC; Koscik, RL; Krause, RA; Oh, JM; Okonkwo, OC; Racine, AM; Sager, MA; Zetterberg, H | 1 |
| Bao, W; Chen, Z; Fei, G; Guan, Y; Pan, S; Pan, X; Ren, S; Zhong, C | 1 |
| Gunter, JL; Jack, CR; Jones, DT; Kantarci, K; Knopman, DS; Lowe, VJ; Machulda, MM; Mielke, MM; Petersen, RC; Reyes, DA; Roberts, RO; Senjem, ML; Therneau, TM; Vemuri, P; Weigand, SD; Wiste, HJ | 1 |
| Appelqvist, H; Bäck, M; LeVine, H; Nilsson, KP | 1 |
| Imabayashi, E; Maikusa, N; Matsuda, H; Sasaki, K; Yuasa, T | 1 |
| Blennow, K; Eusebi, P; Fagan, AM; Kornhuber, J; Lewczuk, P; Matzen, A; Molinuevo, JL; Morris, JC; Parnetti, L | 1 |
| Arai, H; Furukawa, K; Furumoto, S; Harada, R; Ishiki, A; Kudo, Y; Okamura, N; Rowe, CC; Tashiro, M; Tomita, N; Villemagne, VL; Yanai, K | 1 |
| Amariglio, RE; Donovan, NJ; Johnson, KA; Marshall, GA; Okereke, OI; Rentz, DM; Sperling, RA; Vannini, P | 1 |
| Boeve, BF; Ferman, TJ; Fields, JA; Graff-Radford, J; Gunter, JL; Jack, CR; Jones, DT; Kantarci, K; Knopman, DS; Lesnick, TG; Lowe, VJ; Murray, ME; Petersen, RC; Senjem, ML; Spychalla, AJ; Tosakulwong, N | 1 |
| Duan, H; Huang, Z; Jiang, J; Xu, J; Yan, Z; Yu, Z; Zhou, H | 1 |
| Teplow, DB; Yamin, G | 1 |
| Ikari, Y; Ishii, K; Ito, K; Kato, T; Nishio, T; Sakata, M; Senda, M; Yamane, T | 1 |
| Hinckley, SH; Kuret, J; Lin, L; Nanavaty, N | 1 |
| Ashe, KH; Borchelt, DR; Forster, CL; Hemmy, LS; Huang, ES; Kuskowski, MA; Liu, P; McNellis, BM; Rao, ER; Reichl, JH; Vassar, R; Zahs, KR | 1 |
| Brooks, DJ; Edison, P; Fan, Z; Okello, A | 1 |
| Acosta-Cabronero, J; Annus, T; Cardenas-Blanco, A; Coles, JP; Fryer, TD; Holland, AJ; Hong, YT; Menon, DK; Nestor, PJ; Wilson, LR; Zaman, SH | 1 |
| Aisen, PS; Amariglio, R; Chhatwal, J; Donohue, MC; Donovan, N; Gatchel, JR; Hanseeuw, BJ; Jackson, J; Johnson, KA; Marshall, GA; Mormino, EC; Papp, KV; Quiroz, YT; Rentz, DM; Schultz, AP; Sperling, RA | 1 |
| Bark, JS; Betensky, RA; Chhatwal, JP; Cosio, DM; Hanseeuw, BJ; Johnson, KA; LaPoint, M; Mormino, EC; Papp, KV; Rentz, DM; Schultz, AP; Sepulcre, J; Sperling, RA | 1 |
| Abrahamson, EE; Fish, KN; Ikonomovic, MD; Mi, Z; Mufson, EJ; Ryu, AY; Sweet, RA | 1 |
| Alegret, M; Arbizu, J; Becker, JT; Boada, M; Buendía, M; Espinosa, A; Giménez, J; Hendrix, SB; Hernández, I; Ibarria, M; Lafuente, A; Landau, SM; Martínez-Lage, P; Munuera, J; Pesini, P; Pujadas, F; Ruiz, A; Ruiz, S; San José, I; Sarasa, M; Sotolongo-Grau, O; Tárraga, L; Tejero, MA; Valero, S | 1 |
| Hosokawa, C; Hyodo, T; Ishii, K; Kaida, H; Kozuka, T; Murakami, T; Sugimura, K; Tsurusaki, M; Wakabayashi, Y; Yagyu, Y; Yamada, M | 1 |
| Benveniste, H; Butler, T; Carare, RO; de Leon, MJ; Fortea, J; Fossati, S; Glodzik, L; Kim, HJ; Li, Y; Nedergaard, M; Okamura, N; Osorio, RS; Pirraglia, E; Rusinek, H; Saint-Louis, LA; Tsui, WH | 1 |
| Hatashita, S; Wakebe, D | 1 |
| Boellaard, R; Lammertsma, AA; Luurtsema, G; Scheltens, P; Tolboom, N; van Berckel, BN; van Tilburg, EW; Yaqub, M | 1 |
| de Leon, MJ; DeSanti, S; Kemppainen, N; Kim, BC; Li, Y; Mosconi, L; Någren, K; Pirraglia, E; Rinne, JO; Rusinek, H; Tsui, W | 1 |
| Becker, JT; DeKosky, ST; Hoge, JA; Klunk, WE; Lopresti, BJ; Mathis, CA; Price, JC; Raji, CA; Saxton, JA; Tsopelas, ND; Ziolko, SK | 1 |
| Aalto, S; Ahonen, JP; Haaparanta, M; Kalimo, H; Koivunen, J; Någren, K; Paetau, A; Rinne, JO; Rokka, J; Verkkoniemi, A; Viitanen, M | 1 |
| Beach, TG; Castaño, EM; Daugs, ID; Davis, J; Esh, CL; Kalback, WM; Kokjohn, TA; Lue, LF; Luehrs, DC; Patton, RL; Roher, AE; Van Nostrand, WE; Van Vickle, GD; Walker, DG | 1 |
| Hattori, M; In, Y; Ishida, T; Minoura, K; Sugino, E; Sumida, M; Taniguchi, T; Tomoo, K | 1 |
| Levine, H; Walker, LC | 1 |
| Cuasay, K; Devanand, D; Gunn, R; Lai, RY; Libri, V; Mann, JJ; Mikhno, A; Parsey, RV; Pelton, G; Upton, N | 1 |
| Kellaway, LA; Kotwal, GJ; Kulkarni, AP; Pillay, NS | 1 |
| Cardoso, I; Costa, R; Ferreira-da-Silva, F; Saraiva, MJ | 1 |
| Gokce, O; Jan, A; Lashuel, HA; Luthi-Carter, R | 1 |
| Aalto, S; Alafuzoff, I; Jääskeläinen, JE; Leinonen, V; Någren, K; Pirttilä, T; Rinne, J; Rinne, JO; Savolainen, S; Soininen, H; Suotunen, T; Tapiola, T | 1 |
| Archer, HA; Brooks, DJ; Edison, P; Fox, N; Gerhard, A; Hammers, A; Hinz, R; Kennedy, A; Pavese, N; Rossor, M; Tai, YF; Turkheimer, FE | 1 |
| Acosta, O; Ames, D; Bourgeat, P; Currie, J; Ellis, KA; Fripp, J; Jones, G; Maruff, P; Masters, CL; Modat, M; O'Keefe, G; Ourselin, S; Pike, KE; Raniga, P; Rowe, CC; Salvado, O; Villemagne, VL | 1 |
| Kovacs, B; Lumayag, S; Mufson, EJ; Perez, SE; Xu, S | 1 |
| Byun, JH; Kim, DJ; Kim, H; Kim, Y; Lee, WK; Mook-Jung, I; Yoo, KH | 1 |
| Fändrich, M; Klemm, A; Meinhardt, J; Reymann, KG; Rönicke, R; Schröder, UH | 1 |
| Chávez-Macías, L; Harrington, CR; Luna-Muñoz, J; Mena, R; Peralta-Ramirez, J; Wischik, CM | 1 |
| Condron, MM; Ho, L; Ono, K; Pasinetti, GM; Teplow, DB; Wang, J; Zhao, W | 1 |
| Gupta, VB; Indi, SS; Rao, KS | 1 |
| Klunk, WE | 1 |
| Acosta, O; Bourgeat, P; Fripp, J; Jones, G; O'keefe, G; Ourselin, S; Raniga, P; Rowe, C; Salvado, O; Villemagne, V | 1 |
| Klunk, WE; Mathis, CA | 1 |
| Dronkers, NF; Furst, AJ; Gorno-Tempini, ML; Jagust, WJ; Lal, RA; Miller, BL; Mormino, EC; O'Neil, JP; Ogar, JM; Rabinovici, GD; Racine, CA | 1 |
| Borghgraef, P; Bormans, G; Cleynhens, J; Kung, H; Serdons, K; Van Leuven, F; Vanderghinste, D; Verbruggen, A; Verduyckt, T | 1 |
| Acosta, O; Bourgeat, P; Fripp, J; Jones, G; Masters, CL; O'Keefe, G; Ourselin, S; Raniga, P; Rowe, C; Salvado, O; Villemagne, VL | 1 |
| D'Angelo, G; Grant, EA; Mintun, MA; Morris, JC; Roe, CM; Xiong, C | 1 |
| Craig-Schapiro, R; Fagan, AM; Holtzman, DM | 1 |
| Arai, H; Fujiwara, H; Gamoh, S; Hashimoto, M; Katakura, M; Miyazawa, T; Shahdat, HM; Shido, O; Shimada, T; Tanabe, Y; Yamashita, S | 1 |
| Carroll, VL; Dickson, TC; Halliday, GM; King, AE; Shepherd, CE; Sokolova, A; Vickers, JC; Woodhouse, A | 1 |
| Beal, MF; Chen, HL; Gibson, GE; Karuppagounder, SS; Pinto, JT; Xu, H | 1 |
| Baker, SL; Jagust, WJ; Kluth, JT; Koeppe, RA; Madison, CM; Mathis, CA; Miller, BL; Mormino, EC; Rabinovici, GD; Weiner, MW | 1 |
| Archer, HA; Brooks, DJ; Bullock, R; Edison, P; Fox, N; Kennedy, A; Kennedy, J; Okello, A; Rossor, M; Turkheimer, FE; Walker, Z | 1 |
| Engler, H; Hall, H; Långström, B; Razifar, P; Ringheim, A | 1 |
| Alvarez-Larena, A; González-Duarte, P; Lloveras, V; Rimola, A; Rodríguez-Rodríguez, C; Sánchez de Groot, N; Sodupe, M; Vendrell, J; Ventura, S; Vidal-Gancedo, J | 1 |
| DeKosky, ST; Klunk, WE; Lopresti, BJ; Mathis, CA; Price, J; Venneti, S; Wiley, CA | 1 |
| Farde, L; Jeppsson, F; Johnson, AE; Juréus, A; Neelissen, JA; Norman, H; Sandell, J; Ström, P; Svensson, SP; Wensbo, D | 1 |
| Cappai, R; Fodero-Tavoletti, MT; Leone, L; Li, QX; Masters, CL; McLean, CA; Rowe, CC; Villemagne, VL | 1 |
| Barkhof, F; Boellaard, R; Lammertsma, AA; Luurtsema, G; Scheltens, P; Tolboom, N; van Berckel, BN; van der Flier, WM; Windhorst, AD; Yaqub, M | 1 |
| Bulic, B; Mandelkow, E; Mandelkow, EM; Pickhardt, M; Schmidt, B; Waldmann, H | 1 |
| Bormans, G; Kung, H; Mortelmans, L; Serdons, K; Terwinghe, C; Van Laere, K; Verbruggen, A; Vermaelen, P | 1 |
| Amadio, M; Gandy, S; Haroutunian, V; Ho, L; Pascale, A; Pasinetti, GM; Quattrone, A; Racchi, M; Wang, J | 1 |
| Berginc, M; Dekosky, S; Klunk, WE; Lopresti, B; Mathis, CA; McNamee, RL; Price, JC; Rosario, B; Weissfeld, L; Yee, SH; Ziolko, S | 1 |
| Engler, H; Estrada, S; Långström, B; Razifar, P; Ringheim, A; Wall, A | 1 |
| Fagan, AM; Head, D; Holtzman, DM; Marcus, D; Mintun, M; Morris, JC; Shah, AR | 1 |
| Drzezga, A; Förstl, H; Grimmer, T; Henriksen, G; Klunk, WE; Kurz, A; Mathis, CA; Riemenschneider, M; Shiga, T; Wester, HJ | 1 |
| Caccialanza, G; Carotti, A; Catto, M; Colombo, R; De Lorenzi, E; Lanni, C; Racchi, M; Verga, L | 1 |
| Ba, MW; Sun, ZK; Xing, Y; Xu, J; Yang, HQ | 1 |
| Levine, H; Rosen, RF; Walker, LC | 1 |
| Boeve, BF; Gunter, JL; Jack, CR; Kemp, BJ; Knopman, DS; Lowe, VJ; Petersen, RC; Senjem, ML; Shiung, MM; Weigand, SD; Weiner, M; Wiste, HJ | 1 |
| Drzezga, A; Foerstl, H; Grimmer, T; Henriksen, G; Kurz, A; Miederer, I; Mühlau, M; Perneczky, R; Praus, C; Riemenschneider, M; Schwaiger, M; Sorg, C; Wester, HJ; Wohlschläger, A | 1 |
| Higuchi, M | 1 |
| Cassell, MD; Ding, SL; Poremba, A; Van Hoesen, GW | 1 |
| Boellaard, R; Lammertsma, AA; Luurtsema, G; Scheltens, P; Tolboom, N; van Berckel, BN; Windhorst, AD; Yaqub, M | 1 |
| Caroli, A; Frisoni, GB; Kemppainen, N; Lorenzi, M; Någren, K; Rinne, JO | 1 |
| Lucignani, G | 1 |
| Boeve, B; Jack, CR; Kemp, BJ; Knopman, D; Lowe, VJ; Mullan, B; Petersen, RC; Senjem, M; Shiung, M; Smith, G; Weigand, S | 1 |
| Bergström, M; Blomquist, G; Engler, H; Estrada, S; Långström, B; Razifar, P; Ringheim, A | 1 |
| Davis, TJ; Gonzalez-Velasquez, FJ; Kotarek, JA; Moss, MA; Sivakumar, K; Soto-Ortega, DD; Wang, Q; Wu, L | 1 |
| Aalto, S; Kailajärvi, M; Kemppainen, NM; Leinonen, M; Någren, K; Rinne, JO; Scheinin, M; Scheinin, NM | 1 |
| Chen, L; He, R; Wang, X; Wei, Y | 1 |
| Attems, J; Booij, J; Bruecke, T; Dimou, E; Dudczak, R; Knoll, P; Kuntner, C; Langer, O; Mirzaei, S; Mostbeck, G; Prosch, H; Rodrigues, M; Zajicek, B | 1 |
| Bero, AW; Csernansky, JG; Dong, H; Holtzman, DM; Kling, MJ; Timson, BF; Yuede, CM; Zimmerman, SD | 1 |
| Arai, H; Funaki, Y; Furukawa, K; Furumoto, S; Iwata, R; Kato, M; Kudo, Y; Okamura, N; Tashiro, M; Waragai, M; Yanai, K | 1 |
| Baine, M; Georgie, DS; Moffet, DA; Nguyen, TP; Nogaj, LA; Shiferraw, EZ | 1 |
| Cappai, R; Fodero-Tavoletti, MT; Furumoto, S; Kudo, Y; Masters, CL; Mulligan, RS; Okamura, N; Rowe, CC; Villemagne, VL; Yanai, K | 1 |
| Archer, HA; Brooks, DJ; Bullock, R; Edison, P; Fox, NC; Kennedy, A; Koivunen, J; Någren, K; Okello, A; Rinne, JO; Rossor, MN; Turkheimer, FE; Walker, Z | 1 |
| Archer, HA; Brooks, DJ; Edison, P; Hinz, R; Turkheimer, FE | 1 |
| Bormans, G; Brooks, DJ; Koole, M; Nelissen, N; Owenius, R; Thurfjell, L; Van Laere, K; Vandenberghe, R; Vandenbulcke, M | 1 |
| Hashimoto, M; Hossain, S; Katakura, M; Miwa, K; Shido, O; Shimada, T | 1 |
| Blankenstein, MA; Boellaard, R; Lammertsma, AA; Scheltens, P; Tolboom, N; van Berckel, BN; van der Flier, WM; Verwey, NA; Windhorst, AD; Yaqub, M | 1 |
| Ciliax, BJ; Dooyema, J; Gearing, M; Ghiso, JA; Lah, JJ; LeVine, H; Rosen, RF; Walker, LC; Wingo, TS | 1 |
| Jack, CR; Petersen, RC | 1 |
| Aalto, S; Helin, S; Karrasch, M; Kemppainen, N; Koikkalainen, J; Lötjönen, J; Någren, K; Rinne, JO; Scheinin, M; Scheinin, NM; Viitanen, M | 1 |
| Bowles, N; Gaspar, RC; Hepler, RW; Joyce, JG; Shughrue, PJ; Villarreal, SA | 1 |
| Baldwin, A; Collingwood, J; Exley, C; Goodwin, S; House, E; Mold, M | 1 |
| Baralatei, FT; Lauterbach, EC | 1 |
| Durany, N; Fernàndez-Busquets, X; Gella, A; Unzeta, M; Valente, T | 1 |
| Almkvist, O; Axelman, K; Graff, C; Långström, B; Lannfelt, L; Nordberg, A; Schöll, M; Stefanova, E; Wall, A; Westman, E | 1 |
| Foster, NL; Jagust, WJ; Koeppe, RA; Landau, SM; Mathis, CA; Petersen, RC; Price, JC; Reiman, EM; Shaw, LM; Trojanowski, JQ; Weiner, MW | 1 |
| Head, D; Mintun, MA; Morris, JC; Raichle, ME; Sheline, YI; Snyder, AZ; Wang, S | 1 |
| Hulleman, JD; Kelly, JW; Paulsson, JF; Powers, ET; Siegel, SJ; Usui, K | 1 |
| Feinstein, DL; Kalinin, S; Richardson, JC | 1 |
| Fagan, AM; Goate, AM; Head, D; Hinrichs, AL; Holtzman, DM; Mintun, MA; Morris, JC | 1 |
| Bitan, G; Chen, CH; Murakami, K; Rahimi, F; Summers, JL | 1 |
| Bradley, J; Mayne, M; Noonan, C; Richard, K; Supnet, C | 1 |
| Bu, G; Crick, SL; Frieden, C; Hu, X; Lee, JM; Pappu, RV | 1 |
| Arai, H; Furukawa, K; Furumoto, S; Iwata, R; Kudo, Y; Okamura, N; Tashiro, M; Waragai, M; Yanai, K | 1 |
| Fagan, AM; Goate, AM; Grant, EA; Head, D; Holtzman, DM; Mintun, MA; Morris, JC; Roe, CM; Storandt, M | 1 |
| Head, D; Mintun, MA; Morris, JC; Storandt, M | 1 |
| Benzinger, T; Cairns, NJ; Carter, D; Fagan, AM; Felton, A; Holtzman, DM; Ikonomovic, MD; Klunk, WE; Mintun, MA; Morris, JC; Reinwald, LT; Shah, AR; Storandt, M | 1 |
| Boellaard, R; Koene, T; Lammertsma, AA; Scheltens, P; Tolboom, N; van Berckel, BN; van der Flier, WM; Windhorst, AD; Yaqub, M | 1 |
| Aldea, P; Fagan, AM; Holtzman, DM; Mach, RH; Marcus, D; Mintun, MA; Morris, JC; Roe, CM; Shah, AR | 1 |
| Chen, S; Chu, W; Ho, CL; Lam, W; Leung, EY; Mok, V; Wong, A; Wong, KS; Xiong, Y | 1 |
| Goto, Y; Hasegawa, K; Morinaga, A; Naiki, H; Nomura, R; Ookoshi, T; Ozawa, D; Yamada, M | 1 |
| Lee, SY; Shin, J | 1 |
| Anan, M; Hara, H; Kataoka, S; Mutoh, T; Tabira, T; Ueda, A | 1 |
| Fagan, AM; Goate, AM; Holtzman, DM; Mintun, MA; Morris, JC; Roe, CM; Xiong, C | 1 |
| Malar, EJ; Nagarajan, S; Rajadas, J | 1 |
| Gandy, S | 1 |
| Barakos, J; Black, R; Blennow, K; Brooks, DJ; Bullock, R; Fox, NC; Gregg, KM; Grundman, M; Klunk, WE; Koller, M; Liu, E; Mathis, CA; Okello, AA; Rinne, JO; Rodriguez Martinez de Liano, S; Rossor, MN; Schenk, D | 1 |
| Almkvist, O; Engler, H; Forsberg, A; Långström, B; Nordberg, A; Wall, A | 1 |
| Allsop, D; Beeg, M; Canovi, M; Gobbi, M; Mann, DM; Mayes, J; Moore, S; Parkin, E; Taylor, M | 1 |
| Berti, V; de Leon, MJ; De Santi, S; Glodzik, L; Li, Y; Mosconi, L; Murray, J; Någren, K; Rinne, JO; Scheinin, N; Tsui, WH; Vallabhajosula, S; Wang, H; Williams, S | 1 |
| Basu, S; Basun, H; Blennow, K; Darreh-Shori, T; Degerman Gunnarsson, M; Kilander, L; Lannfelt, L; Larsson, A; Lindau, M; Nordberg, A; Wall, A | 1 |
| Chang, KH; de Pablo, Y; Lee, HG; Lee, HP; Shah, K; Smith, MA | 1 |
| Haddix, T; Lee, VM; Nakashima-Yasuda, H; Robinson, J; Trojanowski, JQ; Uryu, K | 1 |
| Hao, J; Lei, G; Li, Z; Liu, L; Liu, R; Miao, J; Su, C; Zhang, P; Zhang, W | 1 |
| Ames, D; Bourgeat, P; Chételat, G; Ellis, KA; Jones, G; Martins, RN; Masters, CL; O'Keefe, GJ; Pike, KE; Rowe, CC; Salvado, O; Szoeke, C; Villemagne, VL | 2 |
| Becker, JA; Buckner, RL; Eng, E; Johnson, KA; Locascio, JJ; Moran, EK; Rentz, DM; Sperling, RA | 1 |
| Cho, SJ; Kim, SH; Kim, SJ; Kim, YB; Lee, SY; Shin, J | 1 |
| Goto, Y; Kawakami, T; Kuboi, R; Kuyama, H; Naiki, H; Nishimura, O; Ozawa, D; Sakurai, K; Shimanouchi, T; Yagi, H | 1 |
| Cuasay, K; Devanand, DP; Dileep Kumar, JS; Gunn, RN; Lai, R; Libri, V; Liu, X; Mann, JJ; Mikhno, A; Parsey, RV; Pelton, GH; Pradhaban, G; Upton, N; van Heertum, R | 1 |
| Chang, HP; Hsiao, IT; Hsu, WC; Jin, LW; Kung, MP; Lin, KJ; Lo, CW; Skovronsky, D; Wai, YY; Wey, SP; Yao, CH; Yen, TC | 1 |
| Bresjanac, M; Kovacs, GG; Mohorko, N; Popović, M; Repovs, G | 1 |
| He, TT; Shen, L; Tian, JH; Yao, SL; Zhang, JM | 1 |
| Bandy, D; Chen, K; Foster, NL; Jagust, WJ; Koeppe, RA; Landau, SM; Mathis, CA; Price, JC; Reiman, EM; Skovronsky, D | 1 |
| Aisen, PS; Blennow, K; Clark, CM; Dean, R; Jack, CR; Jagust, W; Korecka, M; Lee, VM; Lewczuk, P; Petersen, RC; Potter, WZ; Shaw, LM; Siemers, E; Simon, A; Soares, H; Toga, AW; Trojanowski, JQ; Vandeerstichele, H; Weiner, MW | 1 |
| Ames, D; Ellis, KA; Martins, RN; Masters, CL; Rowe, CC; Salvado, O; Szoeke, C; Villemagne, VL | 1 |
| Archimandritis, S; Georgoulias, P; Papatriantafyllou, J; Sifakis, N; Valotassiou, V | 1 |
| Acosta, O; Ames, D; Bourgeat, P; Ellis, KA; Fripp, J; Head, R; Jones, G; Lenzo, N; Martins, R; Masters, CL; Morandeau, L; O'Keefe, G; Pike, KE; Price, R; Raniga, P; Rimajova, M; Robins, P; Rowe, CC; Salvado, O; Szoeke, C; Tochon-Danguy, H; Villemagne, VL | 1 |
| Hu, YE; Mao, JH; Shi, HY; Zhou, AL; Zhu, Y | 1 |
| Baban, B; Crick, SL; Frieden, C; Garai, K; Mustafi, SM | 1 |
| Aisen, PS; Andrawis, JP; Apostolova, LG; Babakchanian, S; Cummings, JL; Green, AE; Hwang, KS; Jack, CR; Jagust, WJ; Koeppe, RA; Mathis, CA; Morra, JH; Petersen, RC; Shaw, LM; Thompson, PM; Toga, AW; Trojanowski, JQ; Weiner, MW | 1 |
| Barkhof, F; Boverhoff, J; Herholz, K; Lammertsma, AA; Raijmakers, PG; Scheltens, P; Tolboom, N; van Berckel, BN; van der Flier, WM; Wattjes, MP; Yaqub, M | 1 |
| Dannals, RF; Endres, CJ; Finley, P; Gao, Y; Horti, AG; Ravert, HT; Savonenko, AV; Valentine, H; Wong, DF | 1 |
| Alexopoulos, P; Drzezga, A; Förschler, A; Förstl, H; Grimmer, T; Henriksen, G; Klunk, WE; Kurz, A; Mathis, CA; Perneczky, R; Sorg, C; Tholen, S; Yousefi, BH | 1 |
| Ishii, K | 4 |
| Andersen, A; Bastin, C; Bormans, G; Brooks, DJ; Buckley, C; Farrar, G; Garraux, G; Hasselbalch, S; Ivanoiu, A; Korner, A; Law, I; Minthon, L; Nelissen, N; Owenius, R; Salmon, E; Thurfjell, L; Triau, E; Van Laere, K; Vandenberghe, R | 1 |
| Almkvist, O; Engler, H; Forsberg, A; Kadir, A; Långström, B; Nordberg, A; Wall, A | 1 |
| Strawn, JR; Tambyraja, R | 1 |
| Guo, Z; Jia, J; Sun, B; Tang, H; Tian, J; Wang, L; Zhang, J | 1 |
| Antošová, A; Bartoš, A; Cechová, L; Gažová, Z; Klaschka, J; Krištofiková, Z; Ríčný, J; Rípová, D | 1 |
| Arai, H; Fukuda, H; Furukawa, K; Furumoto, S; Iwata, R; Kudo, Y; Matsuda, H; Okamura, N; Shao, H; Sugi, K; Tashiro, M; Yanai, K | 1 |
| Huang, W; Lei, H; Wang, X; Xu, W; Zhan, Y; Zhang, S | 1 |
| Bartic, C; Benilova, I; Braeken, D; Broersen, K; Callewaert, G; D'Hooge, R; De Strooper, B; Debulpaep, M; Jonckheere, W; Kuperstein, I; Martins, IC; Rousseau, F; Rozenski, J; Schymkowitz, J; Segers-Nolten, I; Subramaniam, V; Van Der Werf, K; Vandersteen, A | 1 |
| Bugg, JM; Fagan, AM; Goate, AM; Head, D; Holtzman, DM; Liang, KY; Mintun, MA; Morris, JC | 1 |
| Castellani, RJ; Rolston, RK; Smith, MA | 1 |
| Appelt, DM; Balin, BJ; Hallock, LR; Hammond, CJ; Howanski, RJ; Little, CS | 1 |
| Guldiken, B; Guldiken, S | 1 |
| Bahar-Fuchs, A; Chételat, G; Masters, CL; Moss, S; Pike, K; Rowe, C; Savage, G; Villemagne, VL | 1 |
| Hu, C; Jin, Z; Li, S; Lin, HQ; Liu, SJ; Wan, DC; Wang, J; Yang, L | 1 |
| Brooks, DJ; Douglas, J; Edison, P; Fox, NC; Knight, WD; Okello, AA; Rodríguez Martinez de Llano, S; Rossor, MN; Ryan, NS; Turkheimer, FE | 1 |
| Bandopadhyay, D; Mishra, PK; Subramanian, S | 1 |
| Almkvist, O; Darreh-Shori, T; Gonzalez, D; Kadir, A; Marutle, A; Mousavi, M; Mustafiz, T; Nennesmo, I; Nordberg, A; Schöll, M | 1 |
| Borbon, IA; Erickson, RP | 1 |
| Berginc, MD; Hoge, JA; James, JA; Klunk, WE; Laymon, CM; Mathis, CA; Price, JC; Rosario, BL; Weissfeld, LA | 1 |
| Resnick, SM; Sojkova, J | 1 |
| Jagust, WJ; Madison, C; Rabinovici, GD; Rostomian, AH | 1 |
| Cerf, E; Goormaghtigh, E; Gustot, A; Raussens, V; Ruysschaert, JM | 1 |
| Ackermann, U; Ames, D; Bourgeat, P; Chételat, G; Ellis, KA; Jones, G; Klunk, WE; Martins, R; Masters, CL; Mathis, CA; Mulligan, RS; O'Keefe, G; Pike, KE; Rowe, CC; Salvado, O; Szoeke, C; Villemagne, VL | 1 |
| Aisen, PS; Jack, CR; Knopman, DS; Pankratz, VS; Petersen, RC; Senjem, ML; Shaw, LM; Trojanowski, JQ; Vemuri, P; Weigand, SD; Weiner, MW; Wiste, HJ | 1 |
| Ataka, S; Masaki, H; Miki, T; Naka, H; Nakanishi, A; Shimada, H; Shiomi, S; Tamura, A; Tsutada, T; Watanabe, Y; Yamakawa, Y | 1 |
| Aalto, S; Helin, S; Koivunen, J; Någren, K; Parkkola, R; Rinne, JO; Scheinin, N; Vahlberg, T; Viitanen, M; Virta, JR | 1 |
| Baldus, M; Giriens, V; Hickman, DT; Karastaneva, H; López-Deber, MP; Madani, R; Muhs, A; Nagel-Steger, L; Nand, D; Ndao, DM; Nicolau, C; Pfeifer, A; Pihlgren, M; Riesner, D; Silva, AB; St-Pierre, A; Willbold, D | 1 |
| Itami, K; Kirchberg, S; Studer, A; Tani, S; Ueda, K; Yamaguchi, J | 1 |
| Flashner, E; Friedler, A; Raviv, U | 1 |
| Finder, VH; Glockshuber, R; Nitsch, RM; Ovchinnikova, OY; Vodopivec, I | 1 |
| Aigbirhio, FI; Baron, JC; Canales, R; D'Abrera, JC; Fryer, TD; Holland, AJ; Hong, YT; Landt, J; Menon, DK; Zaman, SH | 1 |
| Ames, D; Bush, AI; Ellis, KA; Gupta, VB; Laws, SM; Lui, JK; Martins, RN; Masters, C; Rowe, CC; Szoeke, C; Taddei, K; Villemagne, VL | 1 |
| Fukumura, T; Hattori, S; Higuchi, M; Iwata, N; Ji, B; Kumata, K; Lee, VM; Maeda, J; Mori, H; Okauchi, T; Ono, M; Saido, TC; Staufenbiel, M; Suhara, T; Tomiyama, T; Trojanowski, JQ; Zhang, MR | 1 |
| Becker, JA; Buckner, RL; Carmasin, J; Fischl, B; Greve, DN; Hedden, T; Johnson, KA; Marks, D; Marshall, GA; Maye, J; Putcha, D; Rentz, DM; Salloway, S; Sperling, RA | 1 |
| Ito, Y; Mino, H; Mito, F; Sadasue, H; Sakai, K; Shirahama, C; Utsumi, H; Yamada, K; Yamasaki, T; Yamato, M | 1 |
| Gestwicki, JE; Reinke, AA | 1 |
| Bechinger, B; Dufrêne, YF; Dupres, V; Itkin, A; Raussens, V; Ruysschaert, JM | 1 |
| Andrieux, K; Brambilla, D; Couvreur, P; Hashemi, SH; Le Droumaguet, B; Moghimi, SM; Nicolas, J; Wu, LP | 1 |
| Becker, JA; Drzezga, A; Greve, D; Johnson, KA; Putcha, D; Schultz, AP; Sepulcre, J; Sperling, RA; Sreenivasan, A; Sullivan, C; Talukdar, T; Van Dijk, KR | 1 |
| Ames, D; Chételat, G; Ellis, KA; Good, N; Laws, SM; Martins, RN; Masters, CL; Pike, KE; Rowe, CC; Szoeke, C; Verdile, G; Villemagne, VL | 1 |
| Rinne, JO; Scheinin, M; Scheinin, NM | 1 |
| Arendt, T; Brückner, MK; Hoyer, S; Osmanovic-Barilar, J; Riederer, P; Salkovic-Petrisic, M | 1 |
| Dudczak, R; Haeusler, D; Mitterhauser, M; Philippe, C; Ungersboeck, J; Viernstein, H; Wadsak, W | 1 |
| Broersen, K; Jonckheere, W; Pastore, A; Pauwels, K; Rousseau, F; Rozenski, J; Schymkowitz, J; Vandersteen, A | 1 |
| Ansciaux, E; Burtea, C; Larbanoix, L; Laurent, S; Mahieu, I; Muller, RN; Vander Elst, L | 1 |
| Vallabhajosula, S | 1 |
| Adame, A; Andrews-Zwilling, Y; Flik, G; Giorgini, F; Guidetti, P; Hsieh, EW; Huang, SY; Huang, Y; Laue, G; Lee, J; Louie, JY; Masliah, E; Moussaoui, S; Muchowski, JM; Muchowski, PJ; Notarangelo, FM; Patrick, C; Rassoulpour, A; Sathyasaikumar, KV; Scearce-Levie, K; Schwarcz, R; Truong, J; Wu, HQ; Wu, T; Zwilling, D | 1 |
| Jiji, RD; Wang, M | 1 |
| Griffioen, G; Lagoja, I; Pannecouque, C; Rojasdelaparra, VM; Van Aerschot, A; Wera, S | 1 |
| Haahr, MT; Hasselbalch, SG; Holst, K; Knudsen, GM; Lehel, S; Madsen, K; Marner, L; Neumann, WJ | 1 |
| Bartenstein, P; Dickerson, BC; Drzezga, A; Förster, S; Förstl, H; Graner, P; Grimmer, T; Henriksen, G; Kurz, A; Miederer, I; Wester, HJ; Yousefi, BH | 1 |
| Bao, F; Klein, WL; Lacor, PN; Marutle, A; Nordberg, A; Wicklund, L | 1 |
| Evin, G; Laughton, KM; Li, QX; Lim, NK; Masters, CL; McLean, CA; Rowe, CC; Soon, CP; Villemagne, VL | 1 |
| Aalto, S; Hinkka-Yli-Salomäki, S; Kaprio, J; Koskenvuo, M; Räihä, I; Rinne, JO; Rokka, J; Scheinin, NM | 1 |
| Abrahamson, EE; DeKosky, ST; Ikonomovic, MD; Klunk, WE; Mathis, CA; Mufson, EJ; Scheff, SW; Wuu, J | 1 |
| Farquharson, S; Masters, CL; Rowe, CC; Sirisriro, R; Villemagne, VL; Yates, PA | 1 |
| Cardoso, SM; Costa, RO; Ferreiro, E; Martins, I; Oliveira, CR; Pereira, CM; Santana, I | 1 |
| Bottlaender, M; Chupin, M; Colliot, O; Corlier, F; de Souza, LC; Dubois, B; Habert, MO; Hahn-Barma, V; Lamari, F; Lehéricy, S; Maroy, R; Samri, D; Sarazin, M; Uspenskaya, O | 1 |
| Aiso, S; Chiba, T; Hayashi, K; Sasabe, J; Utsunomiya-Tate, N | 1 |
| Jagust, WJ | 1 |
| Ataka, S; Miki, T; Mori, H; Shimada, H; Takeuchi, J; Wada, Y; Watanabe, Y | 1 |
| Georgopoulos, S; Katsouri, L | 1 |
| Chamberlain, R; Curran, GL; Garwood, M; Hultman, KL; Jack, CR; Marjańska, M; Poduslo, JF; Preboske, GM; Wengenack, TM | 1 |
| Becker, JA; Frey, MT; Johnson, KA; Marshall, GA; Maye, J; Olson, LE; Rentz, DM; Sperling, RA | 1 |
| Arai, H; Fukuda, H; Furukawa, K; Furumoto, S; Iwata, R; Kaneta, T; Kudo, Y; Minoshima, S; Okamura, N; Takahashi, S; Tashiro, M; Yanai, K | 1 |
| Cisek, K; Honson, NS; Jensen, JR; Kuret, J | 1 |
| Ataka, S; Miki, T; Mori, H; Shimada, H; Takechi, H; Tomiyama, T | 1 |
| Engler, H; Gambini, JP; Kilander, L; Långström, B; Lannfelt, L; Santillo, AF; Ulla-Marja, L | 1 |
| Cheng, M; Huang, Q; Li, J; Liu, YN; Peng, Y; Wei, CW; Zhang, L | 1 |
| Benzinger, T; Cirrito, JR; D'Angelo, G; Disabato, BM; Goebel, WD; Hayreh, D; Kim, J; Mintun, MA; Morris, JC; Restivo, JL; Sathyan, A; Sheline, YI; Verges, DK; Yoon, H | 1 |
| Baker, SL; Brandel, MG; Jagust, WJ; Madison, CM; Marks, S; Mormino, EC; Rabinovici, GD | 1 |
| Craig, DW; Foroud, T; Huentelman, MJ; Inlow, M; Jack, CR; Jagust, WJ; Kim, S; Koeppe, RA; Mathis, CA; Nho, K; Potkin, SG; Risacher, SL; Saykin, AJ; Shen, L; Swaminathan, S; Weiner, MW; West, JD; Yoder, KK | 1 |
| Colloby, SJ; O'Brien, JT; Quigley, H | 1 |
| Rowe, C | 1 |
| Furst, AJ; Lal, RA | 1 |
| Gao, H; Jiang, X; Lu, W; Pang, Z; Yin, Q; Yu, Y | 1 |
| Ashford, E; Barkhof, F; Bohrmann, B; Brooks, DJ; Deptula, D; Klunk, WE; Loetscher, H; Ostrowitzki, S; Santarelli, L; Thurfjell, L; Xu, ZX; Yoo, K | 1 |
| Balota, D; Benzinger, TL; Buckles, V; Csernansky, J; Duchek, J; Fagan, A; Grant, E; Head, D; Holtzman, D; Mettenburg, J; Mintun, M; Morris, JC; Roe, CM; Snyder, AZ; Storandt, M; Xiong, C | 1 |
| Cardoso, I; Costa, R; Crowther, DC; Speretta, E | 1 |
| Boeve, BF; Dickson, DW; Ferman, TJ; Jack, CR; Kantarci, K; Knopman, DS; Lowe, VJ; Parisi, JE; Petersen, RC; Przybelski, SA; Senjem, ML; Smith, GE; Weigand, SD | 1 |
| Borkowski, AH; Landreth, GE; Levy, E; Nixon, RA; Wesson, DW; Wilson, DA | 1 |
| Chen, H; Gao, X; Guo, L; Jiang, X; Lai, R; Li, J; Qiu, M; Wu, H; Yan, X; Zhang, Q | 1 |
| Burns, JM; Honea, RA; Townley, RA; Vidoni, ED | 1 |
| Blomquist, G; Engler, H; Forsberg, A; Långström, B; Nordberg, A | 1 |
| Combs, CK; Dhawan, G; Floden, AM | 1 |
| Almansour, AI; Arumugam, N; Ashraf Ali, M; Choon, TS; Elumalai, K; Ismail, R; Kumar, RS; Osman, H; Singh, A | 1 |
| Benzinger, TL; Goate, AM; Mintun, MA; Morris, JC; Sheline, YI; Vlassenko, AG; Xiong, C | 1 |
| Chen, W; Fang, M; Geng, Y; Han, S; Hu, Z; Ling, S; Rudd, JA; Wang, J; Zhang, X | 1 |
| Frederiksen, KS; Gade, A; Haahr, ME; Hasselbalch, BJ; Hasselbalch, SG; Kessing, LV; Knudsen, GM; Law, I; Madsen, K; Price, JC | 1 |
| Bi, BT; Cheng, YF; Li, TJ; Lin, HB; Lin, T; Xu, JP; Zhang, MZ; Zhou, H | 1 |
| Almkvist, O; Carter, SF; Engler, H; Långström, B; Nordberg, A; Schöll, M; Wall, A | 1 |
| Aldea, P; Ances, BM; Benzinger, TL; Christensen, JJ; Clifford, DB; Fagan, AM; Holtzman, DM; Morris, JC; Teshome, M; Thomas, J; Venkat, R | 1 |
| Caso, F; Comi, G; Cursi, M; Falautano, M; Fanelli, G; Leocani, L; Magnani, G; Minicucci, F | 1 |
| Ding, Y; Feng, J; Guo, Y; Han, D; Tan, X; Zhang, S | 1 |
| Chételat, G; Drago, J; Jones, G; Kung, HF; Masters, CL; Mulligan, RS; O'Keefe, G; Okamura, N; Pejoska, S; Pontecorvo, M; Rowe, CC; Skovronsky, DM; Villemagne, VL | 1 |
| Fagan, AM; Head, D; Holtzman, DM; Morris, JC; Storandt, M | 1 |
| Abrahamson, EE; Cohen, AD; Debnath, ML; DeKosky, ST; Hamilton, RL; Ikonomovic, MD; Klunk, WE; Lopez, OL; Mathis, CA; Mizukami, K; Paljug, WR; Price, JC | 1 |
| Jagust, WJ; Landau, SM; Marks, SM; Mormino, EC; O'Neil, JP; Oh, H; Rabinovici, GD; Wilson, RS | 1 |
| Kim, S; Kuret, J; Matzavinos, A; Schafer, KN | 1 |
| Ames, D; Chételat, G; Ellis, KA; Masters, CL; Pike, KE; Rowe, CC; Villemagne, VL | 1 |
| Archer, HA; Brooks, DJ; Edison, P; Gelosa, G; Hinz, R; Ramlackhansingh, A; Thomas, J; Turkheimer, FE | 1 |
| Clark, T; Macauley, MS; Shan, X; Skorobogatko, Y; Vocadlo, DJ; Vosseller, K; Yuzwa, SA | 1 |
| Chan, JG; Jones, G; Masters, CL; Mulligan, RS; O'Keefe, G; Ong, K; Pejoska, S; Rowe, CC; Tochon-Danguy, H; Villemagne, VL; Young, K | 1 |
| Li, M; Qu, K; Qu, X; Ren, J; Yang, X | 1 |
| Aisen, PS; Bernstein, MA; Boeve, BF; Gunter, JL; Jack, CR; Kantarci, K; Knopman, DS; Lesnick, TG; Lowe, V; Petersen, RC; Senjem, ML; Shaw, LM; Trojanowski, JQ; Vemuri, P; Weigand, SD; Weiner, MW; Wiste, HJ | 1 |
| Alexopoulos, P; Auer, F; Drzezga, A; Faust, M; Förstl, H; Grimmer, T; Henriksen, G; Kurz, A; Perneczky, R; Sorg, C; Yousefi, BH | 1 |
| Liu, RT; Wang, L; Wang, SW; Wang, YJ; Xue, D; Yang, Y; Zhang, R; Zhao, M; Zhao, Y | 1 |
| Drzezga, A; Henriksen, G; Huisman, M; Manook, A; Neff, F; Platzer, S; Reder, S; Schoor, M; Schwaiger, M; Settles, M; Velden, J; von der Kammer, H; Voss, A; Wester, HJ; Willuweit, A; Yousefi, BH | 1 |
| Adriaanse, SF; Barkhof, F; Boellaard, R; Foster-Dingley, JC; Lammertsma, AA; Ossenkoppele, R; Scheltens, P; Tolboom, N; van Berckel, BN; van der Flier, WM; Windhorst, AD; Yaqub, M | 1 |
| Ben-Romano, T; Cooper, I; Farfara, D; Frenkel, D; Gazit, E; Levin, A; Scherzer-Attali, R; Segal, D; Segev-Amzaleg, N; Shalev, DE; Shaltiel-Karyo, R; Trudler, D; Vientrov, M | 1 |
| Boeve, BF; Gunter, JL; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; Lowe, V; Petersen, RC; Roberts, RO; Rocca, WA; Senjem, ML; Vemuri, P; Weigand, SD; Wiste, HJ | 1 |
| Brooks, DJ; Gelosa, G | 1 |
| Cummings, M; de Leon, MJ; Glodzik, L; Goldsmith, SJ; Li, Y; McHugh, P; Mosconi, L; Murray, J; Någren, K; Pirraglia, E; Rinne, JO; Scheinin, N; Tsui, WH; Vallabhajosula, S; Viljanen, T; Williams, S | 1 |
| Thurairatnam, S | 1 |
| Barré, P; Eliezer, D; Huster, D; Künze, G; Scheidt, HA; Thomas, L | 1 |
| Bartnik, D; Brener, O; Funke, SA; Liu, H; Nagel-Steger, L; Sehl, T; Wiesehan, K; Willbold, D | 1 |
| Boeve, BF; Gunter, JL; Ivnik, RJ; Jack, CR; Kantarci, K; Knopman, DS; Lowe, V; Petersen, RC; Roberts, RO; Senjem, ML; Vemuri, P; Weigand, SD; Wiste, HJ | 1 |
| Adriaanse, SF; Barkhof, F; Boellaard, R; Kloet, RW; Lammertsma, AA; Ossenkoppele, R; Scheltens, P; Tolboom, N; van Assema, DM; van Berckel, BN; van der Flier, WM; Windhorst, AD; Zwan, MD | 1 |
| Altman, R; Bricarello, DA; Harishchandra, G; Hideg, K; Hong, HS; Jin, LW; Kálai, T; Lorigan, GA; Maezawa, I; Parikh, AN; Petrlova, J; Voss, JC | 1 |
| Jiang, T; Pan, LF; Zhang, YH; Zhi, XL; Zhou, P | 1 |
| Ames, D; Bourgeat, P; Chételat, G; Ellis, KA; Eustache, F; Grassiot, B; Jones, G; Martins, RN; Masters, CL; Rowe, CC; Salvado, O; Villain, N; Villemagne, VL | 1 |
| Burns, JM; Honea, RA; Swerdlow, RH; Vidoni, ED | 1 |
| Combs, CK; Dhawan, G | 1 |
| Arai, H; Furukawa, K; Furumoto, S; Iwata, R; Kudo, Y; Okamura, N; Tashiro, M; Tomita, N; Une, K; Yanai, K | 1 |
| Andrieux, K; Brambilla, D; Canovi, M; Couvreur, P; De Kimpe, L; Gobbi, M; Hashemi, SH; Kóňa, J; Le Droumaguet, B; Lettiero, B; Moghimi, SM; Nicolas, J; Nicolas, V; Scheper, W; Taverna, M; Tvaroška, I; Verpillot, R | 1 |
| Ringman, JM; Teplow, DB; Villemagne, VL | 1 |
| Almkvist, O; Bogdanovic, N; Ferreira, D; Graff, C; Långström, B; Nordberg, A; Schöll, M; Thordardottir, S; Wall, A | 1 |
| Baek, MJ; Jang, JW; Kim, JE; Kim, S; Park, YH | 1 |
| Babiak, M; Caso, F; Comi, G; Filippi, M; Gesierich, B; Gorno-Tempini, ML; Henry, M; Huang, EJ; LaMarre, A; Magnani, G; Miller, BL; Rabinovici, GD; Seeley, WW; Sidhu, M | 1 |
| More, SS; Vartak, AP; Vince, R | 1 |
| Bradley, MA; Fister, SX; Lovell, MA | 1 |
| Baig, I; Beckett, TL; Holler, CJ; Keller, JN; LeVine, H; Matveev, S; Murphy, MP; Niedowicz, DM; Webb, RL | 1 |
| Hayashi, S; Ihara, M; Kimura, H; Matsumura, K; Mori, H; Okamoto, Y; Ono, M; Saji, H; Takahashi, R | 1 |
| Arancio, O; Fa', M; Luo, J; Qin, Z; Tavassoli, E; Teich, AF; Thatcher, GR; VandeVrede, L | 1 |
| Furumoto, S; Harada, R; Kudo, Y; Okamura, N; Yanai, K | 1 |
| Arnold, SE; Boudhar, S; Clark, CM; Pontecorvo, MJ; Wolk, DA; Zhang, Z | 1 |
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| Kato, S; Nishio, T; Ochi, S; Oda, K; Sakata, M; Tanizaki, Y; Tsushima, H | 1 |
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| Cohen, AD; Ikonomovic, MD; Jagust, WJ; Klunk, WE; Mathis, CA; Rabinovici, GD | 1 |
| Gangarajula, S; Ghosh, AK; Huang, X; Kulkarni, S; Pandey, S; Rao, KV; Tang, J; Xu, X | 1 |
| Davatzikos, C; Driscoll, I; Ferrucci, L; Klunk, WE; Kraut, MA; Mathis, CA; O'Brien, RJ; Pletnikova, O; Resnick, SM; Rudow, G; Sojkova, J; Troncoso, JC; Wong, DF; Zhou, Y | 1 |
| Aalto, S; Helin, S; Karrasch, M; Koivunen, J; Någren, K; Rinne, JO; Scheinin, NM; Vahlberg, T; Viitanen, M | 1 |
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| Amariglio, RE; Becker, JA; Carmasin, J; Gidicsin, C; Johnson, KA; Lorius, N; Maye, JE; Pepin, LC; Rentz, DM; Sperling, RA; Sullivan, C; Wadsworth, LP | 1 |
| Ataka, S; Kawabe, J; Miki, T; Mizuno, K; Mori, H; Shimada, H; Shiomi, S; Takeuchi, J; Wada, Y; Watanabe, Y | 1 |
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| Li, M; Qu, X; Ren, J; Xu, C; Yang, X; Zhao, C | 1 |
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| Chen, J; Hecht, MH; McKoy, AF; Schupbach, T | 1 |
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| Akaike, A; Irie, K; Izumi, Y; Izuo, N; Kume, T; Murakami, K; Sato, M | 1 |
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| Ballard, K; Croot, K; Hodges, JR; Leyton, CE | 1 |
| Drzezga, A; Förster, S; Förstl, H; Grimmer, T; Kurz, A; Ortner, M; Perneczky, R; Wutz, C | 1 |
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| Akiyama, T; Kohno, H; Komoriya, T; Shimizu, T; Ye, X; Yoshimune, K | 1 |
| Marutle, A; Ni, R; Nordberg, A | 1 |
| Ames, D; Bush, AI; Ellis, KA; Faux, NG; Gupta, VB; Henley, D; Laws, SM; Li, QX; Martins, RN; Masters, CL; Pike, KE; Rowe, CC; Szoeke, C; Taddei, K; Verdile, G; Villemagne, VL | 1 |
| Jack, CR; Jagust, W; Lee, VM; Shaw, LM; Toledo, E; Toledo, JB; Trojanowski, JQ; Weiner, MW | 1 |
| Baig, I; Beckett, TL; Keller, JN; Kryscio, RJ; LeVine, H; Matveev, S; Mendiondo, MS; Murphy, MP; Niedowicz, DM; Weidner, AM | 1 |
| Li, YN; Liu, RT; Su, YJ; Wang, SW; Yang, SG; Yu, XL; Zhang, H; Zhang, R; Zhao, M; Zhou, WW | 1 |
| Han, H; Kim, H; Kim, YH; Lee, YS; Roh, EJ; Shin, KJ | 1 |
| Agarwal, N; Alkalay, A; Jagust, WJ; Kaufer, D; Miller, BL; Rabinovici, GD; Soreq, H; Zimmerman, G | 1 |
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| Ames, D; Bush, AI; Doecke, JD; Ellis, KA; Faux, NG; Fowler, CJ; Martins, RN; Masters, CL; Pertile, KK; Rembach, A; Roberts, BR; Rowe, CC; Rumble, RL; Trounson, BO; Villemagne, VL; Volitakis, I; Watt, AD; Wilson, W | 1 |
| Dzyuba, SV; Jameson, LP; Smith, NW | 1 |
| Bares, R; Bender, B; Ernemann, U; Horger, M; Mänz, C; Reimold, M | 1 |
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| Adriaanse, SM; Barkhof, F; Binnewijzend, MA; Boellaard, R; Lammertsma, AA; Ossenkoppele, R; Rombouts, SA; Sanz-Arigita, EJ; Scheltens, P; Tolboom, N; van Assema, DM; van Berckel, BN; van der Flier, WM; Windhorst, AD; Wink, AM; Yaqub, M | 1 |
| Gouwens, LK; Nichols, MR; Paranjape, GS; Ruck, BM; Terrill, SE | 1 |
| Adriaanse, SF; Barkhof, F; Boellaard, R; Lammertsma, AA; Ossenkoppele, R; Scheltens, P; van Berckel, BN; van der Flier, WM; Windhorst, AD; Zwan, MD | 1 |
| Brooks, DJ; Carter, SF; Edison, P; Gelosa, G; Herholz, K; Hinz, R; Nordberg, A; Rinne, JO | 1 |
| Cheng, XR; Hau, BY; Kerman, K; Kraatz, HB; Martic, S; Veloso, AJ | 1 |
| Bourgeat, P; Dore, V; Fripp, J; Raniga, P; Rowe, CC; Salvado, O; Villemagne, VL; Zhou, L | 1 |
| Andersson, J; Cselényi, Z; Eriksdotter, M; Farde, L; Forsberg, A; Freund-Levi, Y; Halldin, C; Jeppsson, F; Johnström, P; Julin, P; Juréus, A; Sandell, J; Schou, M; Svensson, S; Swahn, BM; Varnäs, K | 1 |
| Kopito, RR; Melki, R; Quake, SR; Sourigues, Y; Streets, AM | 1 |
| Balducci, C; Biasini, E; Borsello, T; Colombo, L; Diomede, L; Fluharty, BR; Forloni, G; Gobbi, M; Harris, DA; La Vitola, P; Messa, M; Sclip, A; Stravalaci, M | 1 |
| Collin, F; Eury, H; Faller, P; Hureau, C; Sasaki, I | 1 |
| Futaki, S; Hamada, H; Iida, S; Masliah, E; Matoh, N; Sugiura, Y; Suzuki, T; Takehashi, M; Tanaka, S; Ueda, K | 1 |
| Aronow, BJ; Bales, KR; DeMattos, RB; Harmony, JA; Holtzman, DM; O'dell, MA; Parsadanian, M; Paul, SM; Taylor, JW | 1 |
| Aggarwal, A; Balakhaneh, D; Callaway, DJ; Hartley, DM; Lashuel, HA; Teichberg, S | 1 |
| Bacskai, BJ; Games, D; Hyman, BT; Kajdasz, ST; McLellan, ME; Schenk, D; Seubert, P | 1 |
| Capsoni, S; Cattaneo, A; Giannotta, S | 1 |
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| Chen, XL; Hu, HT; Liu, Y; Qian, YH; Ren, HM; Xu, JH | 1 |
| Cottingham, MG; Hollinshead, MS; Vaux, DJ | 1 |
| Signor, L; Staab, D; Staufenbiel, M; Stoeckli, M; Wiederhold, KH | 1 |
| Hou, C; Kung, HF; Kung, MP; Lee, VM; Skovronsky, D; Trojanowski, JQ; Zhang, B; Zhuang, ZP | 1 |
| Craft, S; Watson, GS | 1 |
| Borowski, BJ; Curran, GL; Jack, CR; Macura, SI; Poduslo, JF; Sigurdsson, EM; Wengenack, TM; Wisniewski, T | 1 |
| Harkany, T; Härtig, W; Kacza, J; Paulke, BR; Seeger, J; Varga, C | 1 |
| Devière, J | 1 |
| Bacskai, BJ; D'Amore, JD; Hyman, BT; Kajdasz, ST; McLellan, ME; Stern, EA | 1 |
| Debnath, ML; DeKosky, ST; Hamilton, RL; Holt, DP; Huang, GF; Ikonomovic, MD; Klunk, WE; Mathis, CA; Shao, L; Wang, Y | 1 |
| Bacskai, BJ; Hyman, BT; Kajdasz, ST; McLellan, ME | 1 |
| Gur, TL; Hou, C; Kung, HF; Kung, MP; Lee, VM; Skovronsky, DM; Trojanowski, JQ; Zhang, B; Zhuang, ZP | 1 |
| Dickson, TC; Tan, A; Vickers, JC | 1 |
| Akagi, T; Chui, DH; Takashima, A; Tanaka, N; Yoshiike, Y | 1 |
| Clarke, K; DiCarlo, G; Gordon, MN; Henderson, D; Jackson, J; Morgan, D; Ugen, KE; Wilcock, DM | 1 |
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| Babu-Khan, S; Biere, AL; Citron, M; Landreth, G; Liu, H; Vassar, R; Yan, Q; Zhang, J | 1 |
| Bellmann, C; Giasson, BI; Horiguchi, T; Ischiropoulos, H; Lee, VM; LightFoot, R; Richter-Landsberg, C; Trojanowski, JQ; Uryu, K | 1 |
| Irie, K; Morimoto, A; Murakami, K; Nagao, M; Ohigashi, H; Shimizu, T; Shindo, M; Shirasawa, T | 2 |
| Hasegawa, K; Naiki, H; Ono, K; Takashima, A; Yamada, M; Yoshiike, Y | 2 |
| Hou, C; Jin, LW; Kung, HF; Kung, MP; Zhuang, ZP | 1 |
| Debnath, ML; Holt, DP; Huang, GF; Klunk, WE; Mathis, CA; Shao, L; Wang, Y | 2 |
| Bar-Ner, N; Brandeis, R; Egozi, I; Fisher, A; Haring, R; Kliger-Spatz, M; Marcovitch, I; Natan, N; Pittel, Z; Sonego, H | 1 |
| Bacskai, BJ; Hickey, GA; Huang, GF; Hyman, BT; Kajdasz, ST; Klunk, WE; Mathis, CA; Skoch, J; Wang, Y | 1 |
| Akatsu, H; Kudo, Y; Okamura, N; Sawada, T; Shimadzu, H; Shiomitsu, T; Suemoto, T; Suzuki, M; Yamamoto, T | 1 |
| Czilli, DL; DeMattos, RB; Gitter, B; Holtzman, DM; Kowalewski, T; Legleiter, J | 1 |
| Fonseca, MI; Kawas, CH; Tenner, AJ; Troncoso, JC | 1 |
| Chirita, CN; Kuret, J | 1 |
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| Antoni, G; Ausén, B; Barletta, J; Bergström, M; Blomqvist, G; Debnath, ML; Engler, H; Estrada, S; Holt, DP; Huang, GF; Klunk, WE; Koivisto, P; Långström, B; Lopresti, BJ; Mathis, CA; Nordberg, A; Price, JC; Sandell, J; Savitcheva, I; Wall, A; Wang, Y | 1 |
| Hasegawa, K; Naiki, H; Ono, K; Yamada, M | 1 |
| Brown, J; Crowley, J; Eckman, CB; Gottardi-Littell, N; Lee, JM; Magnuson, D; Rahman, MM; Reiss, AB; Sambamurti, K; Silberman, S; Theisler, C; Wolozin, B; Yager, D | 1 |
| Hasegawa, K; Hayashi, H; Kimura, N; Lemere, CA; Matsuzaki, K; Michikawa, M; Naiki, H; Selkoe, DJ; Shibata, M; Terao, K; Yamaguchi, H; Yamamoto, N; Yanagisawa, K; Yokoseki, T; Yoshikawa, Y | 1 |
| Kuret, J; Necula, M | 1 |
| Emadi, S; Goud, G; Liu, R; Lyubchenko, Y; McAllister, C; Schulz, P; Sierks, MR; Yuan, B; Zameer, A | 1 |
| Mash, D; Mesulam, M; Shaw, P; Weintraub, S | 1 |
| Dudal, S; Gervais, F; Krzywkowski, P; Lacombe, D; Morissette, C; Paquette, J; Tremblay, P | 1 |
| Duff, K; Hashimoto, T; Iwatsubo, T; Kowa, H; Mann, DM; Matsuura, Y; Sakakura, T; Tsuji, S; Wakabayashi, T | 1 |
| Andreoni, S; Appollonio, I; Begni, B; Beretta, S; Brighina, L; Ferrarese, C; Fumagalli, L; Isella, V; Malaplate-Armand, C; Oster, T; Sirtori, E | 1 |
| Larry Sparks, D | 1 |
| Moss, MA; Nichols, MR; Reed, DK; Rosenberry, TL; Varvel, NH | 1 |
| Barbour, R; Bard, F; Bussière, T; Buttini, M; Games, D; Grajeda, H; Guido, T; Khan, K; Schenk, D; Seubert, P | 1 |
| Chang, L; De Felice, FG; Ferreira, ST; Figueroa-Villar, JD; Garcia-Abreu, J; Klein, WL; Liu, R; Saraiva, LM; Vieira, MN | 1 |
| Adam, M; Ahlijanian, MK; Cooper, CB; Gant, T; Helal, CJ; Kang, Z; Kelly, K; Kupchinsky, S; Lucas, JC; Menniti, FS; Peterson, M; Sanner, MA; Tate, B | 1 |
| Bales, KR; Costa, DA; Nilsson, LN; Paul, SM; Potter, H | 1 |
| Cratic-McDaniel, S; Hoh, JH; Moss, MA; Nichols, MR; Reed, DK; Rosenberry, TL | 1 |
| Ambegaokar, SS; Begum, AN; Chen, PP; Cole, GM; Frautschy, SA; Glabe, CG; Kayed, R; Lim, GP; Simmons, MR; Ubeda, OJ; Yang, F | 1 |
| Brown, J; Gee, AD; Hong, G; Judd, DB; Lockhart, A; Lowe, PN; Merritt, AT; Morgenstern, JL; Ye, L | 1 |
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| Bihel, F; Garino, C; Kraus, JL; Laras, Y; Pietrancosta, N; Quéléver, G; Sheha, M; Wolfe, MS | 1 |
| de las Cuevas, N; Hermida, OG; Martín-Requero, A; Muñoz, U | 1 |
| Cai, L; Cohen, RM; Crescenzo, M; Green, MV; Hong, J; Ichise, M; Innis, RB; Jacobowitz, D; Katada, K; Liow, JS; Lu, JQ; Musachio, JL; Pike, VW; Seidel, J; Tipre, D; Toyama, H; Vines, DC; Ye, D; Zoghbi, S | 1 |
| Dahlqvist, C; Ito, A; Kakuyama, H; Näslund, J; Söderberg, L; Thyberg, J; Tjernberg, LO; Winblad, B | 1 |
| Brown, J; Gee, AD; Hong, G; Lockhart, A; Morgenstern, JL; Ye, L | 1 |
| Chung, KC; Kim, J; Lee, CH; Lee, HJ; Lee, ST; Oh, YJ; Paik, SR; Park, SM; Sung, JY; Um, JW | 1 |
| Akasofu, S; Kimura, M; Ogura, H; Sawada, K | 1 |
| DeKosky, ST; Hoge, JA; Holt, DP; Klunk, WE; Lopresti, BJ; Lu, X; Mathis, CA; Meltzer, CC; Price, JC; Ziolko, SK | 1 |
| Barghorn, S; Biernat, J; Mandelkow, E | 1 |
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| Allsop, D; Cooper, LJ; El-Agnaf, OM; Fullwood, NJ; German, MJ; Hayashi, Y; Paleologou, KE; Tabner, BJ; Turnbull, S | 1 |
| Bales, KR; Hartman, RE; Holtzman, DM; Jiang, H; Parsadanian, M; Paul, SM; Wahrle, SE | 1 |
| Koldamova, R; Lefterov, I; Staufenbiel, M | 1 |
| Iwasa, K; Matsumoto, Y; Naiki, H; Noguchi, M; Ono, K; Yamada, M; Yanase, D | 1 |
| Biernat, J; Gazova, Z; Khlistunova, I; Mandelkow, E; Mandelkow, EM; Pickhardt, M; von Bergen, M; Wang, Y | 1 |
| Adriany, G; Borowski, BJ; Curran, GL; Garwood, M; Holasek, SS; Jack, CR; Lin, J; Poduslo, JF; Preboske, GM; Reyes, DA; Wengenack, TM | 1 |
| He, Y; Luo, Y; Tang, H; Zhou, H | 1 |
| Abrahamson, EE; Debnath, ML; DeKosky, ST; Holt, DP; Huang, GF; Ikonomovic, MD; Klunk, WE; Koldamova, RP; Lefterov, IM; Lopresti, BJ; Mathis, CA; Price, JC; Shao, L | 1 |
| Bryszewska, M; Cladera, J; Cortijo-Arellano, M; Klajnert, B | 1 |
| DeKosky, ST; Hoge, JA; Klunk, WE; Lopresti, BJ; Lu, X; Mathis, CA; Meltzer, CC; Price, JC; Schimmel, K; Tsopelas, ND; Ziolko, SK | 1 |
| Akagi, T; Chui, DH; Fukuda, T; Hashikawa, T; Kimura, T; Kudo, T; Miyasaka, T; Murayama, M; Nakano, Y; Park, JM; Takashima, A; Takeda, M; Tanemura, K; Tatebayashi, Y | 1 |
| Papadopoulos, M; Patsis, G; Pelecanou, M; Pirmettis, IC; Raptopoulou, C; Terzis, A; Tzanopoulou, S | 1 |
| Asada, T; Mizukami, K; Moro, K; Sato, S; Tanaka, Y | 1 |
| Billings, LM; Caccamo, A; Fisher, A; Green, KN; LaFerla, FM; Martinez-Coria, H; Oddo, S | 1 |
| Frankish, H | 1 |
| Arai, H; Fujiwara, H; Furukawa, K; Hara, M; He, M; Higuchi, M; Iwasaki, K; Kudo, Y; Maeda, S; Maruyama, M; Ohizumi, Y; Saido, TC; Seki, T; Takashima, A; Tomita, N | 1 |
| Arnold, SE; Chatterjee, A; Clark, CM; Coslett, HB; Farmer, J; Forman, MS; Grossman, M; Hurtig, HI; Johnson, JK; Karlawish, JH; Lee, VM; Miller, BL; Rosen, HJ; Trojanowski, JQ; Van Deerlin, V | 1 |
| Gong, Y; Hughes, JA; King, MA; Klein, RL; Meyer, EM; Meyers, CA | 1 |
| Baglioni, S; Bagnoli, S; Cecchi, C; Fiorillo, C; Liguri, G; Nacmias, B; Nosi, D; Pensalfini, A; Relini, A; Sorbi, S | 1 |
| Archer, HA; Barnes, J; Brooks, DJ; Edison, P; Fox, NC; Frost, C; Rossor, MN; Yeatman, T | 1 |
| Cai, L; Pike, VW; Wang, Y; Wei, J; Wu, C | 1 |
| Almkvist, O; Blomquist, G; Engler, H; Forsberg, A; Långström, B; Larsson, E; Nordberg, A; Ringheim, A; Savitcheva, I; Wall, A | 1 |
| DeKosky, ST; Dence, CS; Klunk, WE; Larossa, GN; Lee, SY; Mach, RH; Mathis, CA; Mintun, MA; Morris, JC; Sheline, YI | 1 |
| DeKosky, ST; Hoge, JA; Klunk, WE; Lopresti, BJ; Mathis, CA; Price, JC; Weissfeld, LA; Ziolko, SK | 1 |
| Avila, J; Hernández, F; Moreno, FJ; Pérez, M; Santa-María, I | 1 |
| Kudo, Y | 1 |
| Aalto, S; Brück, A; Helin, S; Kailajärvi, M; Kemppainen, NM; Någren, K; Oikonen, V; Parkkola, R; Rinne, JO; Scheinin, M; Viitanen, M; Wilson, IA | 2 |
| Naiki, H; Noguchi-Shinohara, M; Ono, K; Yamada, M; Yoshita, M | 1 |
| Bourhim, M; Kruzel, M; Nicotera, T; Srikrishnan, T | 1 |
| Archer, HA; Brooks, DJ; Cutler, D; Edison, P; Fox, N; Hammers, A; Hinz, R; Hotton, G; Kennedy, A; Pavese, N; Rossor, M; Tai, YF | 1 |
| Chen, K; Maley, J; Yu, PH | 1 |
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| Baud, S; Keeley, FW; Miao, M; Pomès, R; Rauscher, S | 1 |
| Bigio, EH; Chang, L; De Felice, FG; Fernandez, S; Gong, Y; Khuon, D; Klein, WL; Krafft, GA; Lacor, PN; Lambert, MP; Shaw, P; Velasco, PT; Viola, KL | 1 |
| Frisoni, GB | 1 |
| Akula, KC; Baru, V; Chiningiri, B; Dasari, V; Gandhi, S; Kaur, R; Shiradkar, MR | 1 |
| Holtzman, DM | 1 |
| Fukuda, H; Okamura, N | 1 |
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| Ackermann, U; Berlangieri, S; Cherk, M; Gong, SJ; Jones, G; Lee, ST; Masters, CL; Ng, S; O'Keefe, G; Rowe, CC; Saunder, T; Smith, C; Tochon-Danguy, H; Villemagne, VL | 1 |
| Arai, H; Furukawa, K; Furumoto, S; Itoh, M; Iwata, R; Kudo, Y; Maruyama, M; Okamura, N; Tashiro, M; Yanai, K | 1 |
| Baker, SL; Chetty, S; Furst, AJ; Jagust, WJ; Klunk, WE; Mathis, CA; Miller, BL; Mormino, EC; O'Neil, JP; Pagliaro, TA; Patel, P; Rabinovici, GD; Racine, CA; Rosen, HJ | 1 |
| Dannals, R; Fan, H; Holt, DP; Klunk, WE; Mathis, CA; Resnick, SM; Wong, DF; Ye, W; Zhou, Y | 1 |
| Aerssens, J; Alvidrez, J; Anand, R; Faison, WE; Farrer, LA; Jarvik, L; Manly, J; McRae, T; Mintzer, JE; Murphy, GM; Olin, JT; Regier, D; Sano, M; Schultz, SK | 1 |
| Almkvist, O; Blomquist, G; Engler, H; Forsberg, A; Hagman, G; Långström, B; Nordberg, A; Ringheim, A; Wall, A | 1 |
| Ackermann, U; Cowie, TF; Darby, D; Dickinson, KL; Gong, SJ; Klunk, WE; Maruff, P; Masters, CL; Mathis, CA; Merory, J; Ng, S; O'Keefe, G; Pike, K; Price, JC; Rowe, CC; Savage, G; Smith, C; Tochon-Danguy, H; Villemagne, VL; Woodward, M | 1 |
| Enokita, M; Hashimoto, T; Hori, Y; Iwatsubo, T; Kato, M; Kinoshita, H; Toyo'oka, T | 1 |
| Ikeda, K; Matsuzaki, K; Okada, T; Wakabayashi, M | 1 |
| Nordberg, A | 1 |
| Akula, KC; Bhetalabhotala, S; Padhalingappa, MB; Pinninti, RR; Shiradkar, MR; Thummanagoti, S; Tupe, DA | 1 |
| Becker, JA; Dekosky, ST; Fischman, AJ; Greenberg, SM; Gregas, M; Johnson, KA; Kinnecom, C; Klunk, WE; Mathis, CA; Moran, EK; Price, JC; Rentz, DM; Rosand, J; Salat, DH; Smith, EE | 1 |
| Beach, TG; Joyce, JN; Lamb, JR; Leppert, D; Libri, V; Lockhart, A; Osredkar, T; Sue, LI; Ye, L | 1 |
| Masters, CL; Ng, SY; Rowe, CC; Villemagne, VL | 1 |
| Beach, TG; Brune, D; Esh, CL; Fifield, FG; Fraser, PE; Kalback, WM; Kokjohn, TA; Lopez, J; Luehrs, DC; McLaurin, J; Newel, AJ; Patton, RL; Poston, M; Roher, AE; Van Vickle, GD; Westaway, D | 1 |
| Elstner, EF; Heilmann, J; Kraus, B; Wolff, H | 1 |
| Austin, CP; Honson, NS; Huang, W; Inglese, J; Johnson, RL; Kuret, J | 1 |
| Engler, H; Kilander, L; Långström, B; Lannfelt, L; Lindau, M; Nordberg, A; Santillo, AF; Savitcheva, I; Wang, SX | 1 |
| Hadjipavlou-Litina, D; Kontogiorgis, CA; Luo, Y; Xu, Y | 1 |
| Faller, P; Gras, E; Leuma Yona, R; Mazères, S | 1 |
| Klunk, WE; Maruff, P; Masters, CL; Mathis, CA; Moss, SA; Ng, S; Pike, KE; Rowe, CC; Savage, G; Villemagne, VL | 1 |
| Higuchi, M; Irie, T; Iwata, N; Ji, B; Maeda, J; Maruyama, M; Mori, H; Okauchi, T; Ono, M; Saido, TC; Staufenbiel, M; Suhara, T; Suzuki, K; Tomiyama, T | 1 |
| Cheng, RH; Hong, HS; Jin, LW; Kung, HF; Kung, MP; Laferla, FM; Lam, KS; Liu, R; Maezawa, I; Oddo, S; Wu, CY | 1 |
| DeKosky, S; Diehl-Schmid, J; Drzezga, A; Grimmer, T; Henriksen, G; Klunk, WE; Kurz, A; Mathis, CA; Perneczky, R; Price, J; Schwaiger, M; Stangier, I; Wester, HJ | 1 |
| Aalto, S; Karrasch, M; Kemppainen, NM; Någren, K; Oikonen, V; Parkkola, R; Rinne, JO; Savisto, N; Viitanen, M | 1 |
| Gupta, VB; Rao, KS | 1 |
| Bares, R; Berg, D; Eschweiler, GW; Gaenslen, A; Gasser, T; Leyhe, T; Liepelt, I; Machulla, HJ; Maetzler, W; Mittelbronn, M; Reimold, M; Reischl, G; Schweitzer, K; Solbach, C; Uebele, M | 1 |
| Bourgeat, P; O'Keefe, G; Ourselin, S; Raniga, P; Rowe, C; Villemagne, V | 1 |
| Calissano, P; Cicconi, S; Ciotti, MT; Gentile, A; Parasassi, T; Serafino, A | 1 |
| Fisher, A | 2 |
| Boeve, BF; Jack, CR; Kemp, BJ; Klunk, WE; Knopman, DS; Lowe, VJ; Mathis, CA; Petersen, RC; Senjem, ML; Shiung, MM; Weigand, SD | 1 |
| Chierici, S; Dolphin, GT; Dumy, P; Garcia, J; Ouberai, M | 1 |
| Abrahamson, EE; Bi, W; Debnath, ML; DeKosky, ST; Hamilton, RL; Hope, CE; Ikonomovic, MD; Isanski, BA; Klunk, WE; Lopresti, BJ; Mathis, CA; Paljug, WR; Price, JC; Tsopelas, ND; Ziolko, S | 1 |
| Drzezga, A; Förstl, H; Grimmer, T; Henriksen, G; Klunk, WE; Kurz, A; Mathis, CA; Wester, HJ | 1 |
| Datki, ZL; Földi, I; Hunya, A; Penke, B; Soós, K; Szabó, A; Szegedi, V; Zádori, D; Zarándi, M | 1 |
| Aalto, S; Kemppainen, N; Laru, L; Mononen, H; Någren, K; Parkkola, R; Remes, AM; Rinne, JO; Tuominen, H | 1 |
| Cai, HC; Cheng, DF; Han, YJ; Lei, B; Wang, J; Wu, MX; Yin, DZ; Zhang, H; Zhang, L; Zheng, MQ | 1 |
| Linazasoro, G | 1 |
| Thangavel, R; Van Hoesen, GW; Zaheer, A | 1 |
| Lyketsos, CG; Mielke, MM; Rosenberg, PB; Szekely, CA; Zandi, PP | 1 |
| Arendt, T; Bigl, V; Brückner, MK; Marcova, L | 1 |
| Biernat, J; Mandelkow, E; Mandelkow, EM; Schweers, O | 1 |
| Buée, L; Buée-Scherrer, V; Delacourte, A; Marugg, RA; Morrison, JH; Riederer, BM; Vickers, JC | 1 |
| Cesura, AM; Chan-Palay, V; Da Prada, M; Huber, G; Löffler, J; Luque, JM; Richards, JG; Saura, J | 1 |
| Aimi, Y; Kawamata, T; McGeer, EG; McGeer, PL; Yasuhara, O | 1 |
| Cotman, CW; Cummings, BJ; Su, JH | 1 |
| Gómez-Ramos, P; Morán, MA; Navarro, C; Probst, A | 1 |
| Alvarez, A; Casanueva, OI; Garrido, J; Inestrosa, NC; Linker, C; Moreno, RD; Pérez, CA; Soto, C; Vicente, M | 1 |
| Kim, SH; Suh, YH | 1 |
| Naiki, H; Nakakuki, K | 1 |
| Rogers, J; Webster, S | 1 |
| Bubb, MR; Caviston, TL; DeTure, MA; Erdos, GW; Purich, DL; Whittaker, SD; Zhang, EY | 1 |
| Beavis, RC; Frangione, B; Golabek, A; Lalowski, M; Lemere, CA; Selkoe, DJ; Wisniewski, HM; Wisniewski, T | 1 |
| Hansen, LA; Mallory, M; Masliah, E; Vincent, I; Wakabayashi, K | 1 |
| Cunningham, AM; Hipkiss, AR; Mayer, S; Michaelis, J; Müller, R; Münch, G; Neumann, A; Riederer, P; Schinzel, R | 1 |
| Klivényi, P; Vécsei, L | 1 |
| Morrison, JH; Sampson, VL; Vickers, JC | 1 |
| Belanger, G; Mendis, T; Mohr, E; Murtha, S; Nair, NP; Pappas, B; Sampson, M | 1 |
| Johnson-Wood, K; Lin, C; Mallory, M; Masliah, E; McConlogue, L; Mucke, L; Wyss-Coray, T | 1 |
| Guillozet, AL; Mash, DC; Mesulam, MM; Smiley, JF | 1 |
| Crutcher, KA; Joshi, SN | 1 |
| Crutcher, KA; Scott, SA; Tolar, M | 1 |
| Beal, MF; Kowall, NW; McKee, AC; Schumacher, JS | 1 |
| Geula, C; Mesulam, MM; Saroff, DM; Wu, CK | 1 |
| Friedhoff, P; Mandelkow, E; Mandelkow, EM; Schneider, A | 1 |
| Butterfield, DA; Drake, J; Green, M; Jordan, B; Koppal, T; Subramaniam, R; Yatin, S | 1 |
| Beffert, U; Poirier, J | 1 |
| Barelli, H; Checler, F; De Nanteuil, G; Hirsch, E; Morain, P; Petit, A; Wilk, S | 1 |
| Dickson, DW; Lee, VM; Trojanowski, JQ; Wang, J | 1 |
| Boelens, WC; Bosman, GJ; de Jong, WW; Overkamp, PS; Reijnen-Aalbers, A; Renkawek, K; Stege, GJ; van Rijk, AF; Verschuure, P | 1 |
| Butterfield, DA; Koppal, T; Varadarajan, S; Yatin, SM | 1 |
| George, AR; Howlett, DR; Markwell, RE; Owen, DE; Ward, RV | 1 |
| Cannady, SB; Combs, CK; Johnson, DE; Karlo, JC; Landreth, GE | 1 |
| Ankarcrona, M; Benedikz, E; Cowburn, RF; Flood, F; Mehta, ND; Nilsberth, C; Perez-Tur, J; Tanii, H; Winblad, B | 1 |
| Bales, KR; Fagan, AM; Holtzman, DM; Mackey, B; McKeel, D; Olney, J; Parsadanian, M; Paul, SM; Sartorius, LJ; Tenkova, T; Wozniak, D | 1 |
| Chu, CC; Parvizi, J; Van Hoesen, GW | 1 |
| Dagø, L; Olesen, OF | 1 |
| Bodles, AM; Campbell, P; Guthrie, DJ; Harriott, P; Irvine, GB | 1 |
| Ihara, Y; Misonou, H; Morishima-Kawashima, M | 1 |
| Kaneko, I; Kubo, T; Morimoto, K | 1 |
| Hatters, DM; Howlett, GJ; Lawrence, LJ; MacPhee, CE; Sawyer, WH | 1 |
| Hamilton, RL; Klunk, WE; Styren, GC; Styren, SD | 1 |
| Liang, JJ | 1 |
| Bacskai, BJ; Christie, RH; Hyman, BT; Kajdasz, ST; Webb, WW; Williams, RM; Zipfel, WR | 1 |
| Colombo, L; Forloni, G; Girola, L; Salmona, M; Tagliavini, F | 1 |
| Azizeh, BY; Cotman, CW; Cribbs, DH; Head, E; Lott, IT; Tenner, AJ | 1 |
| Exley, C; Korchazhkina, OV | 2 |
| Gur, TL; Hou, C; Kung, HF; Kung, MP; Lee, VM; Plössl, K; Skovronsky, DM; Trojanowski, JQ; Zhuang, ZP | 1 |
| Fu, Y; Tang, XC; Zhou, J | 1 |
| Hashioka, S; Imoto, T; Monji, A; Tashiro , K; Tashiro, N; Ueda, T; Utsumi, H; Yoshida, I | 1 |
| Beach, TG; Fisher, A; Potter, PE; Sue, LI; Walker, DG | 1 |
| Duff, K; La Francois, J; Matsuoka, Y; Picciano, M | 1 |
| Gordon, DJ; Meredith, SC; Sciarretta, KL | 1 |
| Bales, KR; Cummins, DJ; DeLong, CA; Esterman, MA; Fishman, CE; Hanson, JC; Jordan, WH; Paul, SM; White, SL | 1 |
| Dickson, TC; Vickers, JC | 1 |
| Cruz, L; Duff, K; Hsiao-Ashe, K; Hyman, BT; Irizarry, MC; Knowles, RB; Le, R; Stanley, HE; Urbanc, B | 1 |
| Eckelman, WC | 1 |
| Debnath, ML; Holt, DP; Huang, GF; Klunk, WE; Mathis, CA; Wang, Y | 1 |
| Barker, JL; Chang, Y; Li, BS; Ma, W; Maric, D; Rubinow, DR; Xing, GQ; Zhang, L | 1 |
| Emson, PC; Iritani, S; Niizato, K | 1 |
| Baysang, G; Brockhaus, M; Hess, C; Ly, C; Meier, F; Müller-Spahn, F; Olivieri, G; Savaskan, E | 1 |
| Mallory, M; Mante, M; Masliaha, E; Rockenstein, E; Sisk, A | 1 |
| Daniels, WM; Hendricks, J; Salie, R; Taljaard, JJ | 1 |
| Bacskai, BJ; Debnath, ML; Frosch, MP; Holt, DP; Huang, GF; Hyman, BT; Kajdasz, ST; Klunk, WE; Mathis, CA; McLellan, ME; Wang, Y | 1 |
| Abramova, NA; Bennett, JP; Cassarino, DS; Khan, SM; Painter, TW | 1 |
| Balaban, TS; Greferath, R; Hopkins, RJ; Lazarte, JE; Nicolau, C | 1 |
| Fukushima, K; Isobe, Y; Kiuchi, Y | 1 |
| Eckert, A; Haass, C; Leutz, S; Marques, CA; Müller, WE; Steiner, B | 1 |
| Bouras, C; Guntern, R; Hof, PR; Vallet, PG | 1 |
| Bouras, C; Delacourte, A; Golaz, J; Guntern, R; Hof, PR; Robakis, NK; Vallet, PG | 1 |
| Clincke, B; De Deyn, PP; Pickut, BA; Saerens, J; Van de Velde, V; Van Peer, A; Verslegers, W; Woestenborghs, R | 1 |
| Cerwinski, S; Chou, SJ; Emory, C; Fisher, GH; Frey, WH; Man, EH; Martin, T; Payan, IL | 1 |
| Van Hoesen, GW; Vogt, BA; Vogt, LJ | 1 |
| Davous, P; Fallet-Bianco, C; Lamour, Y; Roudier, M; Senut, MC | 2 |
| Benes, FM; Bird, ED; Farol, PA; Majocha, RE; Marotta, CA | 1 |
| Davous, P; Fallet-Bianco, C; Lamour, Y; Roudier, M | 1 |
| German, DC; Saper, CB | 1 |
| Defossez, A; Delacourte, A; Peers, MC; Persuy, P | 1 |
| Défossez, A; Delacourte, A | 1 |
| Brion, JP; Delaère, P; Duyckaerts, C; Hauw, JJ; Poulain, V | 1 |
| Behrouz, N; Defossez, A; Delacourte, A; Hublau, P; Mazzuca, M | 1 |
| Jungalwala, FB; Majocha, RE; Marotta, CA; Rodenrys, A | 1 |
| Robbins, TW | 1 |
| Défossez, A; Delacourte, A; Lenders, MB; Mazzuca, M; Peers, MC | 1 |
| KuKuruga, D; Palutke, M; Roher, A; Wolfe, D | 1 |
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| German, DC; Saper, CB; White, CL | 1 |
58 review(s) available for thiazoles and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
A systematic review on drugs for synaptic plasticity in the treatment of dementia.
Topics: Alzheimer Disease; Benzamides; Bryostatins; Humans; Levetiracetam; Neuronal Plasticity; Piperidines; Pyridines; Thiazoles | 2022 |
Presenilin-1 mutation is associated with a hippocampus defect in alzheimer's disease: Meta-Analysis for neuroimaging research.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Fluorodeoxyglucose F18; Glucose; Hippocampus; Humans; Magnetic Resonance Imaging; Neuroimaging; Organ Size; Positron-Emission Tomography; Presenilin-1; Radiopharmaceuticals; Thiazoles | 2020 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; Emergency Service, Hospital; Empathy; Emulsions; Endothelial Cells; Endurance Training; Energy Intake; Enterovirus A, Human; Environment; Environmental Monitoring; Enzyme Assays; Enzyme Inhibitors; Epithelial Cells; Epithelial-Mesenchymal Transition; Epoxide Hydrolases; Epoxy Compounds; Erythrocyte Count; Erythrocytes; Escherichia coli; Escherichia coli Infections; Escherichia coli Proteins; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Esophagectomy; Estrogens; Etanercept; Ethiopia; Ethnicity; Ethylenes; Exanthema; Exercise; Exercise Test; Exercise Tolerance; Extracellular Matrix; Extracorporeal Membrane Oxygenation; Eye Infections, Fungal; False Negative Reactions; Fatty Acids; Fecal Microbiota Transplantation; Feces; Female; Femur Neck; Fermentation; Ferritins; Fetal Development; Fibroblast Growth Factor-23; Fibroblast Growth Factors; Fibroblasts; Fibroins; Fish Proteins; Flavanones; Flavonoids; Focus Groups; Follow-Up Studies; Food Handling; Food Supply; Food, Formulated; Forced Expiratory Volume; Forests; Fractures, Bone; Fruit and Vegetable Juices; Fusobacteria; G1 Phase Cell Cycle Checkpoints; G2 Phase Cell Cycle Checkpoints; Gamma Rays; Gastrectomy; Gastrointestinal Microbiome; Gastrointestinal Stromal Tumors; Gefitinib; Gels; Gemcitabine; Gene Amplification; Gene Expression; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Neoplastic; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Gene-Environment Interaction; Genotype; Germany; Glioma; Glomerular Filtration Rate; Glucagon; Glucocorticoids; Glycemic Control; Glycerol; Glycogen Synthase Kinase 3 beta; Glycolipids; Glycolysis; Goblet Cells; Gram-Negative Bacterial Infections; Granulocyte Colony-Stimulating Factor; Graphite; Greenhouse Effect; Guanidines; Haemophilus influenzae; HCT116 Cells; Health Knowledge, Attitudes, Practice; Health Personnel; Health Services Accessibility; Health Services Needs and Demand; Health Status Disparities; Healthy Volunteers; Heart Failure; Heart Rate; Heart Transplantation; Heart-Assist Devices; HEK293 Cells; Heme; Heme Oxygenase-1; Hemolysis; Hemorrhage; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis B, Chronic; Hepatocytes; Hexoses; High-Throughput Nucleotide Sequencing; Hippo Signaling Pathway; Histamine; Histamine Agonists; Histidine; Histone Deacetylase 2; HIV Infections; HIV Reverse Transcriptase; HIV-1; Homebound Persons; Homeodomain Proteins; Homosexuality, Male; Hospice and Palliative Care Nursing; HSP70 Heat-Shock Proteins; Humans; Hyaluronan Receptors; Hydrogen; Hydrogen Peroxide; Hydrogen-Ion Concentration; Hydrolysis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemia; Hypoglycemic Agents; Hypoxia; Idiopathic Interstitial Pneumonias; Imaging, Three-Dimensional; Imatinib Mesylate; Immunotherapy; Implementation Science; Incidence; INDEL Mutation; Induced Pluripotent Stem Cells; Industrial Waste; Infant; Infant, Newborn; Inflammation; Inflammation Mediators; Infliximab; Infusions, Intravenous; Inhibitory Concentration 50; Injections; Insecticides; Insulin-Like Growth Factor Binding Protein 5; Insulin-Secreting Cells; Interleukin-1; Interleukin-17; Interleukin-8; Internship and Residency; Intestines; Intracellular Signaling Peptides and Proteins; Ion Transport; Iridaceae; Iridoid Glucosides; Islets of Langerhans Transplantation; Isodon; Isoflurane; Isotopes; Italy; Joint Instability; Ketamine; Kidney; Kidney Failure, Chronic; Kidney Function Tests; Kidney Neoplasms; Kinetics; Klebsiella pneumoniae; Knee Joint; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lactate Dehydrogenase 5; Laparoscopy; Laser Therapy; Lasers, Semiconductor; Lasers, Solid-State; Laurates; Lead; Leukocyte L1 Antigen Complex; Leukocytes, Mononuclear; Light; Lipid Peroxidation; Lipopolysaccharides; Liposomes; Liver; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Locomotion; Longitudinal Studies; Lopinavir; Lower Urinary Tract Symptoms; Lubricants; Lung; Lung Diseases, Interstitial; Lung Neoplasms; Lymphocyte Activation; Lymphocytes, Tumor-Infiltrating; Lymphoma, Mantle-Cell; Lysosomes; Macrophages; Male; Manganese Compounds; MAP Kinase Kinase 4; Mass Screening; Maternal Health; Medicine, Chinese Traditional; Melanoma, Experimental; Memantine; Membrane Glycoproteins; Membrane Proteins; Mesenchymal Stem Cell Transplantation; Metal Nanoparticles; Metalloendopeptidases; Metalloporphyrins; Methadone; Methane; Methicillin-Resistant Staphylococcus aureus; Mexico; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Mice, Nude; Mice, SCID; Mice, Transgenic; Microarray Analysis; Microbial Sensitivity Tests; Microbiota; Micronutrients; MicroRNAs; Microscopy, Confocal; Microsomes, Liver; Middle Aged; Milk; Milk, Human; Minority Groups; Mitochondria; Mitochondrial Membranes; Mitochondrial Proteins; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Epidemiology; Molecular Structure; Molecular Weight; Multilocus Sequence Typing; Multimodal Imaging; Muscle Strength; Muscle, Skeletal; Muscular Diseases; Mutation; Mycobacterium tuberculosis; Myocardial Stunning; Myristates; NAD(P)H Dehydrogenase (Quinone); Nanocomposites; Nanogels; Nanoparticles; Nanotechnology; Naphthalenes; Nasal Cavity; National Health Programs; Necrosis; Needs Assessment; Neoadjuvant Therapy; Neonicotinoids; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasm Transplantation; Neoplasms; Neoplastic Stem Cells; Netherlands; Neuroblastoma; Neuroprotective Agents; Neutrophils; NF-kappa B; NFATC Transcription Factors; Nicotiana; Nicotine; Nitrates; Nitrification; Nitrites; Nitro Compounds; Nitrogen; Nitrogen Dioxide; North Carolina; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Nucleic Acid Hybridization; Nucleosomes; Nutrients; Obesity; Obesity, Morbid; Oceans and Seas; Oncogene Protein v-akt; Oncogenes; Oocytes; Open Reading Frames; Osteoclasts; Osteogenesis; Osteoporosis; Osteoporosis, Postmenopausal; Outpatients; Ovarian Neoplasms; Ovariectomy; Overweight; Oxazines; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxides; Oxidoreductases; Oxygen; Oxygen Inhalation Therapy; Oxygenators, Membrane; Ozone; Paclitaxel; Paenibacillus; Pain Measurement; Palliative Care; Pancreatic Neoplasms; Pandemics; Parasympathetic Nervous System; Particulate Matter; Pasteurization; Patient Preference; Patient Satisfaction; Pediatric Obesity; Permeability; Peroxiredoxins; Peroxynitrous Acid; Pharmaceutical Services; Pharmacists; Pharmacy; Phaseolus; Phenotype; Phoeniceae; Phosphates; Phosphatidylinositol 3-Kinases; Phospholipid Transfer Proteins; Phospholipids; Phosphorus; Phosphorylation; Photoperiod; Photosynthesis; Phylogeny; Physical Endurance; Physicians; Pilot Projects; Piperidines; Pituitary Adenylate Cyclase-Activating Polypeptide; Plant Extracts; Plant Leaves; Plant Proteins; Plant Roots; Plaque, Atherosclerotic; Pneumonia; Pneumonia, Viral; Point-of-Care Testing; Polyethylene Glycols; Polymers; Polysorbates; Pore Forming Cytotoxic Proteins; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Postprandial Period; Poverty; Pre-Exposure Prophylaxis; Prediabetic State; Predictive Value of Tests; Pregnancy; Pregnancy Trimester, First; Pregnancy, High-Risk; Prenatal Exposure Delayed Effects; Pressure; Prevalence; Primary Graft Dysfunction; Primary Health Care; Professional Role; Professionalism; Prognosis; Progression-Free Survival; Prolactin; Promoter Regions, Genetic; Proof of Concept Study; Proportional Hazards Models; Propylene Glycol; Prospective Studies; Prostate; Protein Binding; Protein Biosynthesis; Protein Isoforms; Protein Kinase Inhibitors; Protein Phosphatase 2; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein Transport; Proteoglycans; Proteome; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins c-ret; Proto-Oncogene Proteins p21(ras); Proton Pumps; Protons; Protoporphyrins; Pseudomonas aeruginosa; Pseudomonas fluorescens; Pulmonary Artery; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Pulmonary Veins; Pyrazoles; Pyridines; Pyrimidines; Qualitative Research; Quinoxalines; Rabbits; Random Allocation; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Histamine H3; Receptors, Immunologic; Receptors, Transferrin; Recombinant Proteins; Recurrence; Reference Values; Referral and Consultation; Regional Blood Flow; Registries; Regulon; Renal Insufficiency, Chronic; Reperfusion Injury; Repressor Proteins; Reproducibility of Results; Republic of Korea; Research Design; Resistance Training; Respiration, Artificial; Respiratory Distress Syndrome; Respiratory Insufficiency; Resuscitation; Retinal Dehydrogenase; Retreatment; Retrospective Studies; Reverse Transcriptase Inhibitors; Rhinitis, Allergic; Ribosomal Proteins; Ribosomes; Risk Assessment; Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Copper Coordination Compounds as Biologically Active Agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Infective Agents; Antineoplastic Agents; Biological Factors; Cell Line, Tumor; Copper; Drug Design; Drug Evaluation, Preclinical; Flow Cytometry; HEK293 Cells; Humans; Inhibitory Concentration 50; Ions; Isotopes; Ligands; MCF-7 Cells; Mycobacterium tuberculosis; Oxidation-Reduction; Positron-Emission Tomography; Spectrophotometry; Tetrazolium Salts; Thiazoles; Tuberculosis | 2020 |
Partial volume correction in arterial spin labeling perfusion MRI: A method to disentangle anatomy from physiology or an analysis step too far?
Topics: Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Carbon Radioisotopes; Cerebral Arteries; Cognitive Dysfunction; Entorhinal Cortex; Hippocampus; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Membrane Glycoproteins; Nerve Tissue Proteins; Neuroimaging; Organ Size; Perfusion; Positron-Emission Tomography; Pyridines; Pyrrolidinones; Radiopharmaceuticals; Spin Labels; Synaptic Vesicles; Thiazoles | 2021 |
Masitinib for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Benzamides; Cognition; Humans; Piperidines; Protein Kinase Inhibitors; Pyridines; Thiazoles | 2021 |
Fyn Kinase Activity and Its Role in Neurodegenerative Disease Pathology: a Potential Universal Target?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzamides; Central Nervous System; Dasatinib; Humans; Molecular Targeted Therapy; Multiple Sclerosis; Myelin Sheath; Nerve Tissue Proteins; Neurodegenerative Diseases; Oligodendroglia; Parkinson Disease; Piperidines; Proto-Oncogene Proteins c-fyn; PrPC Proteins; Pyridines; Receptors, N-Methyl-D-Aspartate; T-Cell Antigen Receptor Specificity; T-Lymphocyte Subsets; tau Proteins; Thiazoles | 2021 |
Clinical Aspects of Alzheimer's Disease.
Topics: Adaptor Proteins, Signal Transducing; Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Aphasia; Apolipoprotein E4; ATP-Binding Cassette Transporters; Atrophy; Brain; Cognition; HLA Antigens; Humans; Magnetic Resonance Imaging; Memory; Neuroimaging; Nuclear Proteins; Positron-Emission Tomography; Presenilins; Receptors, Complement 3b; Thiazoles; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; Tumor Suppressor Proteins | 2017 |
[Amyloid-selective Photooxygenation toward Treatment for Amyloid Diseases].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Catalysis; Dinitrocresols; Drug Discovery; Humans; Oxidation-Reduction; Photochemical Processes; Protein Aggregation, Pathological; Protein Binding; Riboflavin; Thiazoles | 2018 |
Fluorescent Imaging of Amyloid-β Deposits in Brain: An Overview of Probe Development and a Highlight of the Applications for In Vivo Imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Congo Red; Curcumin; Fluorescent Dyes; Humans; Microscopy, Fluorescence, Multiphoton; Positron Emission Tomography Computed Tomography; Thiazoles | 2018 |
Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Brain; Endophenotypes; Female; Genome-Wide Association Study; Humans; Male; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Thiazoles | 2021 |
Amyloid imaging with PET in early Alzheimer disease diagnosis.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Asymptomatic Diseases; Brain; Carbon Radioisotopes; Chromosome Aberrations; Cognitive Dysfunction; Diagnosis, Differential; Disease Progression; DNA Mutational Analysis; Fluorine Radioisotopes; Genetic Carrier Screening; Humans; Positron-Emission Tomography; Prognosis; Statistics as Topic; Thiazoles | 2013 |
Neuroinflammation and β amyloid deposition in Alzheimer's disease: in vivo quantification with molecular imaging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Humans; Inflammation; Isoquinolines; Mitochondrial ADP, ATP Translocases; Molecular Imaging; Monoamine Oxidase; Positron-Emission Tomography; Radiopharmaceuticals; tau Proteins; Thiazoles | 2014 |
Pittsburgh compound B retention and progression of cognitive status--a meta-analysis.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Cognitive Dysfunction; Disease Progression; Humans; Middle Aged; Positron-Emission Tomography; Thiazoles | 2014 |
Early detection of Alzheimer's disease using PiB and FDG PET.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Cognition; Cognitive Dysfunction; Fluorodeoxyglucose F18; Glucose; Humans; Positron-Emission Tomography; Thiazoles | 2014 |
Use of amyloid PET across the spectrum of Alzheimer's disease: clinical utility and associated ethical issues.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Asymptomatic Diseases; Benzothiazoles; Brain; Carbon Radioisotopes; Cognitive Dysfunction; Dementia; Ethylene Glycols; Fluorine Radioisotopes; Humans; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2014 |
(11)C-PIB-PET for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI).
Topics: Aged; Alzheimer Disease; Aniline Compounds; Carbon Radioisotopes; Cognitive Dysfunction; Dementia; Disease Progression; Early Diagnosis; Humans; Positron-Emission Tomography; Prospective Studies; Sensitivity and Specificity; Thiazoles | 2014 |
Meta-analytic comparison between PIB-PET and FDG-PET results in Alzheimer's disease and MCI.
Topics: Alzheimer Disease; Aniline Compounds; Cognitive Dysfunction; Fluorodeoxyglucose F18; Glucose; Humans; Positron-Emission Tomography; Thiazoles | 2015 |
Masitinib for the treatment of mild to moderate Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzamides; Humans; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Thiazoles | 2015 |
Aβ42 and Aβ40: similarities and differences.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Antibodies, Monoclonal; Brain Chemistry; Humans; Molecular Probes; Molecular Sequence Data; Peptide Fragments; Protein Aggregation, Pathological; Protein Structure, Secondary; Proteolysis; Styrenes; Thiazoles | 2015 |
Current Research Therapeutic Strategies for Alzheimer's Disease Treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzamides; Benzodioxoles; Brain; Disease Models, Animal; Humans; Mice; Neurons; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fyn; PrPC Proteins; Pyridines; Quinazolines; Receptor, Metabotropic Glutamate 5; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Synapses; Thiazoles | 2016 |
Advances in development of fluorescent probes for detecting amyloid-β aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Boron Compounds; Curcumin; Fluorescent Dyes; Humans; Optical Imaging; Stilbenes; Thiazoles; Thiophenes | 2016 |
Amyloid Imaging: Poised for Integration into Medical Practice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Biomarkers; Brain; Clinical Trials as Topic; Ethylene Glycols; Humans; Nitriles; Positron-Emission Tomography; Radiopharmaceuticals; Sensitivity and Specificity; Stilbenes; Thiazoles; Translational Research, Biomedical | 2017 |
The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Humans; Positron-Emission Tomography; Thiazoles | 2008 |
Biomarkers of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Benzoxazoles; Biomarkers; Brain; Cerebrovascular Circulation; Humans; Isoprostanes; Microglia; Nitriles; Protease Nexins; Radiography; Receptors, Cell Surface; Regional Blood Flow; Stilbenes; tau Proteins; Thiazoles | 2009 |
Development of tau aggregation inhibitors for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Databases, Factual; Humans; tau Proteins; Tauopathies; Thiazoles | 2009 |
Clinical applications of PET amyloid imaging: an update.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Cognition Disorders; Humans; Nitriles; Positron-Emission Tomography; Thiazoles | 2009 |
Amyloid PET and MRI in Alzheimer's disease and mild cognitive impairment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain Mapping; Cognition Disorders; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Positron-Emission Tomography; Thiazoles | 2009 |
Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Biomarkers; Cognition Disorders; Cross-Sectional Studies; Diagnostic Imaging; Homocysteine; Humans; Isoprostanes; Peptide Fragments; Positron-Emission Tomography; Prospective Studies; Reproducibility of Results; tau Proteins; Thiazoles | 2010 |
[Amyloid PET in Alzheimer research].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Carbon Radioisotopes; Humans; Phenanthrolines; Positron-Emission Tomography; Radiopharmaceuticals; Rhombencephalon; Thiazoles | 2010 |
Alzheimer disease.
Topics: Age Distribution; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antioxidants; Biomarkers; Brain; Cerebral Amyloid Angiopathy; Cholinergic Agents; Dementia; Diagnosis, Differential; Diet, Mediterranean; Estrogen Replacement Therapy; Global Health; Humans; Immunotherapy; Incidence; Mutation; Nerve Growth Factors; Neurofibrillary Tangles; Plaque, Amyloid; Positron-Emission Tomography; Prevalence; Risk Factors; tau Proteins; Thiazoles; Treatment Outcome | 2010 |
In vivo human amyloid imaging.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Cognition Disorders; Humans; Magnetic Resonance Imaging; Positron-Emission Tomography; Thiazoles | 2011 |
Insight into amyloid structure using chemical probes.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Coloring Agents; Congo Red; Humans; Molecular Sequence Data; Protein Conformation; Thiazoles | 2011 |
Nanotechnologies for Alzheimer's disease: diagnosis, therapy, and safety issues.
Topics: Acridines; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biocompatible Materials; Biomarkers; Brain; Chromones; Drug Delivery Systems; Ferric Compounds; Gold; Humans; Magnetite Nanoparticles; Nanoparticles; Thiazoles | 2011 |
Amyloid imaging as a surrogate marker in clinical trials in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Clinical Trials as Topic; Fluorodeoxyglucose F18; Humans; Models, Neurological; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2011 |
Positron emission tomography radiopharmaceuticals for imaging brain Beta-amyloid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzothiazoles; Cerebral Cortex; Dementia; Ethylene Glycols; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Neurofibrillary Tangles; Nitriles; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2011 |
PET imaging of brain amyloid in dementia: a review.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Cognition Disorders; Dementia; Frontotemporal Dementia; Humans; Image Processing, Computer-Assisted; Lewy Body Disease; Positron-Emission Tomography; Thiazoles | 2011 |
Diagnostic accuracy of 18 F-FDG and 11 C-PIB-PET for prediction of short-term conversion to Alzheimer's disease in subjects with mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Clinical Trials as Topic; Cognitive Dysfunction; Cross-Sectional Studies; Fluorodeoxyglucose F18; Humans; Positron-Emission Tomography; Radiopharmaceuticals; ROC Curve; Sensitivity and Specificity; Thiazoles | 2012 |
Relationship between memory performance and β-amyloid deposition at different stages of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Brain; Humans; Magnetic Resonance Imaging; Memory Disorders; Positron-Emission Tomography; Thiazoles | 2012 |
The prognostic value of amyloid imaging.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Cognitive Dysfunction; Humans; Plaque, Amyloid; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Stilbenes; Thiazoles | 2012 |
Hematopoietic prostaglandin D synthase inhibitors.
Topics: Alzheimer Disease; Animals; Asthma; Dermatitis, Atopic; Drug Design; Enzyme Inhibitors; Humans; Intramolecular Oxidoreductases; Leukodystrophy, Globoid Cell; Lipocalins; Muscular Dystrophies; Niacinamide; Piperidines; Pulmonary Disease, Chronic Obstructive; Pyrazoles; Pyrimidines; Rhinitis, Allergic, Perennial; Spinal Cord Injuries; Thiazoles | 2012 |
Using Pittsburgh Compound B for in vivo PET imaging of fibrillar amyloid-beta.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Animals; Apolipoproteins E; Humans; Molecular Imaging; Positron-Emission Tomography; Thiazoles | 2012 |
Dye-binding assays for evaluation of the effects of small molecule inhibitors on amyloid (aβ) self-assembly.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Coloring Agents; Congo Red; Drug Discovery; False Positive Reactions; Fluorescent Dyes; Humans; Reproducibility of Results; Thiazoles | 2012 |
[Imaging diagnosis of Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Brain; Carbon Radioisotopes; Cerebral Cortex; Diagnostic Imaging; Diffusion Tensor Imaging; Dominance, Cerebral; Energy Metabolism; Fluorodeoxyglucose F18; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Nerve Net; Organ Size; Oxygen; Positron-Emission Tomography; Radiographic Image Enhancement; Regional Blood Flow; Thiazoles | 2012 |
The role of insulin resistance in the pathogenesis of Alzheimer's disease: implications for treatment.
Topics: Alzheimer Disease; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Rosiglitazone; Thiazoles; Thiazolidinediones | 2003 |
Do selective cyclo-oxygenase inhibitors eliminate the adverse events associated with nonsteroidal anti-inflammatory drug therapy?
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase Inhibitors; Humans; Lactones; Meloxicam; Neoplasms; Pyrazoles; Sulfonamides; Sulfones; Thiazines; Thiazoles | 2002 |
GABA(A) receptor subtype selective cognition enhancers.
Topics: Alzheimer Disease; Animals; Benzodiazepines; Cognition; Cognition Disorders; Disease Models, Animal; GABA Agonists; Haplorhini; Hippocampus; Humans; Mice; Mice, Transgenic; Receptors, GABA-A; Thiazoles; Thiophenes | 2003 |
M1 muscarinic agonists can modulate some of the hallmarks in Alzheimer's disease: implications in future therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cell Death; Disease Models, Animal; Down-Regulation; Humans; Memory Disorders; Mice; Muscarinic Agonists; Oxidative Stress; Piperidines; Quinuclidines; Receptor, Muscarinic M1; Spiro Compounds; tau Proteins; Thiazoles; Thiophenes | 2003 |
Amyloid imaging of Alzheimer's disease using Pittsburgh Compound B.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Diagnostic Imaging; Humans; Thiazoles | 2006 |
[Introduction to and general remarks on molecular imaging].
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzoxazoles; Brain; Carbon Radioisotopes; Diagnostic Imaging; Humans; Mice; Molecular Probes; Piperidines; Plaque, Amyloid; Positron-Emission Tomography; Propionates; Thiazoles | 2007 |
[Molecular imaging of beta-amyloid plaques in the brain].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Brain; Congo Red; Humans; Mice; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2007 |
Potential ethnic modifiers in the assessment and treatment of Alzheimer's disease: challenges for the future.
Topics: Aged; Alzheimer Disease; Cross-Cultural Comparison; Donepezil; Ethnicity; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Thiazoles; White People | 2007 |
Amyloid imaging in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Animals; Benzothiazoles; Benzoxazoles; Brain; Carbon Radioisotopes; Fluorine Radioisotopes; Humans; Longitudinal Studies; Mice; Mice, Transgenic; Molecular Structure; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2007 |
M1 muscarinic agonists target major hallmarks of Alzheimer's disease--an update.
Topics: Alzheimer Disease; Animals; Humans; Muscarinic Agonists; Piperidines; Receptor, Muscarinic M1; Spiro Compounds; Thiazoles | 2007 |
Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies.
Topics: Alzheimer Disease; Aniline Compounds; Biomarkers; Biomarkers, Pharmacological; Brain; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Disease Progression; Drug Design; Humans; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Psychotropic Drugs; Radioligand Assay; Thiazoles | 2008 |
[Neurodegeneration: aging and dementia. Etiopathogenic role of electron transport disorders. Therapeutic possibilities].
Topics: Aged; Aging; Alzheimer Disease; Calcium Channel Blockers; Cerebellar Diseases; Dementia; Electron Transport; Female; Humans; Huntington Disease; Lamotrigine; Male; Middle Aged; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Parkinson Disease; Riluzole; Thiazoles; Triazines | 1997 |
[Neurotoxicity of beta-amyloid].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cells, Cultured; Excitatory Amino Acids; Hippocampus; Humans; Nerve Degeneration; Oxidation-Reduction; Rats; Solubility; Stereoisomerism; Tetrazolium Salts; Thiazoles | 2000 |
Therapeutic strategies in Alzheimer's disease: M1 muscarinic agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Carbamates; Cheirogaleidae; Disease Models, Animal; Humans; Muscarinic Agonists; Neuroprotective Agents; Phenylcarbamates; Piperidines; Receptor, Muscarinic M1; Receptors, Muscarinic; Rivastigmine; Signal Transduction; tau Proteins; Thiazoles | 2000 |
19 trial(s) available for thiazoles and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Masitinib for mild-to-moderate Alzheimer's disease: results from a randomized, placebo-controlled, phase 3, clinical trial.
Topics: Activities of Daily Living; Alzheimer Disease; Humans; Memantine; Thiazoles | 2023 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor Proteins, Signal Transducing; Adenine; Adenocarcinoma; Adipogenesis; Administration, Cutaneous; Administration, Ophthalmic; Adolescent; Adsorption; Adult; Aeromonas hydrophila; Aerosols; Aged; Aged, 80 and over; Aging; Agriculture; Air Pollutants; Air Pollution; Airway Remodeling; Alanine Transaminase; Albuminuria; Aldehyde Dehydrogenase 1 Family; Algorithms; AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase; Alzheimer Disease; Amino Acid Sequence; Ammonia; Ammonium Compounds; Anaerobiosis; Anesthetics, Dissociative; Anesthetics, Inhalation; Animals; Anti-Bacterial Agents; Anti-HIV Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Antibiotics, Antineoplastic; Antibodies, Antineutrophil Cytoplasmic; Antibodies, Monoclonal, Humanized; Antifungal Agents; Antigens, Bacterial; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Antitubercular Agents; Antiviral Agents; Apolipoproteins E; Apoptosis; Arabidopsis; Arabidopsis Proteins; Arsenic; Arthritis, Rheumatoid; Asthma; Atherosclerosis; ATP-Dependent Proteases; Attitude of Health Personnel; Australia; Austria; Autophagy; Axitinib; Bacteria; Bacterial Outer Membrane Proteins; Bacterial Proteins; Bacterial Toxins; Bacterial Typing Techniques; Bariatric Surgery; Base Composition; Bayes Theorem; Benzoxazoles; Benzylamines; beta Catenin; Betacoronavirus; Betula; Binding Sites; Biological Availability; Biological Oxygen Demand Analysis; Biomarkers; Biomarkers, Tumor; Biopsy; Bioreactors; Biosensing Techniques; Birth Weight; Blindness; Blood Chemical Analysis; Blood Gas Analysis; Blood Glucose; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Blood-Brain Barrier; Blotting, Western; Body Mass Index; Body Weight; Bone and Bones; Bone Density; Bone Resorption; Borates; Brain; Brain Infarction; Brain Injuries, Traumatic; Brain Neoplasms; Breakfast; Breast Milk Expression; Breast Neoplasms; Bronchi; Bronchoalveolar Lavage Fluid; Buffaloes; Cadherins; Calcification, Physiologic; Calcium Compounds; Calcium, Dietary; Cannula; Caprolactam; Carbon; Carbon Dioxide; Carboplatin; Carcinogenesis; Carcinoma, Ductal; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Renal Cell; Cardiovascular Diseases; Carps; Carrageenan; Case-Control Studies; Catalysis; Catalytic Domain; Cattle; CD8-Positive T-Lymphocytes; Cell Adhesion; Cell Cycle Proteins; Cell Death; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Phone Use; Cell Proliferation; Cell Survival; Cell Transformation, Neoplastic; Cell Transformation, Viral; Cells, Cultured; Cellulose; Chemical Phenomena; Chemoradiotherapy; Child; Child Development; Child, Preschool; China; Chitosan; Chlorocebus aethiops; Cholecalciferol; Chromatography, Liquid; Circadian Clocks; Circadian Rhythm; Circular Dichroism; Cisplatin; Citric Acid; Clinical Competence; Clinical Laboratory Techniques; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clostridioides difficile; Clostridium Infections; Coculture Techniques; Cohort Studies; Cold Temperature; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type XI; Color; Connective Tissue Diseases; Copper; Coronary Angiography; Coronavirus 3C Proteases; Coronavirus Infections; Cost of Illness; Counselors; COVID-19; COVID-19 Testing; Creatine Kinase; Creatinine; Cross-Over Studies; Cross-Sectional Studies; Cryoelectron Microscopy; Cryosurgery; Crystallography, X-Ray; Cues; Cultural Competency; Cultural Diversity; Curriculum; Cyclic AMP Response Element-Binding Protein; Cyclin-Dependent Kinase Inhibitor p21; Cycloparaffins; Cysteine Endopeptidases; Cytokines; Cytoplasm; Cytoprotection; Databases, Factual; Denitrification; Deoxycytidine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diagnosis, Differential; Diatoms; Diet; Diet, High-Fat; Dietary Exposure; Diffusion Magnetic Resonance Imaging; Diketopiperazines; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Disease Progression; Disease-Free Survival; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA, Bacterial; DNA, Viral; Docetaxel; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drosophila; Drosophila melanogaster; Drug Carriers; Drug Delivery Systems; Drug Liberation; Drug Repositioning; Drug Resistance, Bacterial; Drug Resistance, Multiple, Bacterial; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Edema; Edible Grain; Education, Graduate; Education, Medical, Graduate; Education, Pharmacy; Ehlers-Danlos Syndrome; Electron Transport Complex III; Electron Transport Complex IV; Electronic Nicotine Delivery Systems; 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Risk Factors; Ritonavir; Rivers; RNA Interference; RNA-Seq; RNA, Messenger; RNA, Ribosomal, 16S; RNA, Small Interfering; Rosuvastatin Calcium; Rural Population; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Salivary Ducts; Salivary Gland Neoplasms; San Francisco; SARS-CoV-2; Satiation; Satiety Response; Schools; Schools, Pharmacy; Seasons; Seawater; Selection, Genetic; Sequence Analysis, DNA; Serine-Threonine Kinase 3; Sewage; Sheep; Sheep, Domestic; Shock, Hemorrhagic; Signal Transduction; Silver; Silymarin; Single Photon Emission Computed Tomography Computed Tomography; Sirolimus; Sirtuin 1; Skin; Skin Neoplasms; Skin Physiological Phenomena; Sleep Initiation and Maintenance Disorders; Social Class; Social Participation; Social Support; Soil; Soil Microbiology; Solutions; Somatomedins; Soot; Specimen Handling; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis; Spinal Fractures; Spirometry; Staphylococcus aureus; STAT1 Transcription Factor; STAT3 Transcription Factor; Streptomyces coelicolor; Stress, Psychological; Stroke; Stroke Volume; Structure-Activity Relationship; Students, Medical; Students, Pharmacy; Substance Abuse Treatment Centers; Sulfur Dioxide; Surface Properties; Surface-Active Agents; Surveys and Questionnaires; Survival Analysis; Survival Rate; Survivin; Sweden; Swine; Swine, Miniature; Sympathetic Nervous System; T-Lymphocytes, Regulatory; Talaromyces; Tandem Mass Spectrometry; tau Proteins; Telemedicine; Telomerase; Telomere; Telomere Homeostasis; Temperature; Terminally Ill; Th1 Cells; Thiamethoxam; Thiazoles; Thiophenes; Thioredoxin Reductase 1; Thrombosis; Thulium; Thyroid Cancer, Papillary; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Time Factors; Titanium; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed; TOR Serine-Threonine Kinases; Transcription Factor AP-1; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transcriptome; Transforming Growth Factor beta1; Transistors, Electronic; Translational Research, Biomedical; Transplantation Tolerance; Transplantation, Homologous; Transportation; Treatment Outcome; Tretinoin; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tubulin Modulators; Tumor Microenvironment; Tumor Necrosis Factor Inhibitors; Tumor Necrosis Factor-alpha; Twins; Ultrasonic Therapy; Ultrasonography; Ultraviolet Rays; United States; Up-Regulation; Uranium; Urethra; Urinary Bladder; Urodynamics; Uromodulin; Uveitis; Vasoconstrictor Agents; Ventricular Function, Left; Vero Cells; Vesicular Transport Proteins; Viral Nonstructural Proteins; Visual Acuity; Vital Capacity; Vitamin D; Vitamin D Deficiency; Vitamin K 2; Vitamins; Volatilization; Voriconazole; Waiting Lists; Waste Disposal, Fluid; Wastewater; Water Pollutants, Chemical; Whole Genome Sequencing; Wine; Wnt Signaling Pathway; Wound Healing; Wounds and Injuries; WW Domains; X-linked Nuclear Protein; X-Ray Diffraction; Xanthines; Xenograft Model Antitumor Assays; YAP-Signaling Proteins; Yogurt; Young Adult; Zebrafish; Zebrafish Proteins; Ziziphus | 2016 |
Effect of Feru-guard 100M on amyloid-beta deposition in individuals with mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Angelica archangelica; Aniline Compounds; Atrophy; Brain; Carbon Radioisotopes; Cognitive Dysfunction; Coumaric Acids; Disease Progression; Female; Humans; Japan; Male; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2020 |
Changes in brain amyloid-β accumulation after donepezil administration.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Donepezil; Female; Functional Neuroimaging; Humans; Indans; Male; Nootropic Agents; Piperidines; Positron-Emission Tomography; Thiazoles; Time Factors | 2017 |
Pharmacodynamics of cholinesterase inhibitors suggests add-on therapy with a low-dose carbamylating inhibitor in patients on long-term treatment with rapidly reversible inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Therapy, Combination; Fluorescence; Follow-Up Studies; Humans; Indans; Physostigmine; Piperidines; Thiazoles; Time Factors | 2014 |
Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antibodies, Monoclonal, Humanized; Apolipoprotein E4; Benzothiazoles; Cerebral Cortex; Female; Heterozygote; Humans; Male; Middle Aged; Positron-Emission Tomography; Thiazoles; Treatment Outcome | 2015 |
Biomarker Exposure-Response Analysis in Mild-To-Moderate Alzheimer's Disease Trials of Bapineuzumab.
Topics: Alzheimer Disease; Aniline Compounds; Antibodies, Monoclonal, Humanized; Apolipoproteins E; Area Under Curve; Biomarkers; Double-Blind Method; Female; Humans; Immunologic Factors; Magnetic Resonance Imaging; Male; Mental Status and Dementia Tests; Positron-Emission Tomography; tau Proteins; Thiazoles; Treatment Outcome | 2016 |
Early Postmenopausal Transdermal 17β-Estradiol Therapy and Amyloid-β Deposition.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Aged; Alzheimer Disease; Aniline Compounds; Apolipoproteins E; Brain; Cognition; Double-Blind Method; Estradiol; Estrogens; Estrogens, Conjugated (USP); Female; Follow-Up Studies; Humans; Middle Aged; Neuropsychological Tests; Postmenopause; Retrospective Studies; Thiazoles | 2016 |
Voxel-based analysis of 11C-PIB scans for diagnosing Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Female; Humans; Magnetic Resonance Imaging; Male; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2008 |
Phase 1 study of the Pittsburgh compound B derivative 18F-flutemetamol in healthy volunteers and patients with probable Alzheimer disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Female; Humans; Male; Metabolic Clearance Rate; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Reference Values; Thiazoles; Tissue Distribution | 2009 |
11C-PiB PET assessment of change in fibrillar amyloid-beta load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Brain; Brain Mapping; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Immunologic Factors; Male; Positron-Emission Tomography; Severity of Illness Index; Thiazoles; Time Factors; Treatment Outcome | 2010 |
Whole-body biodistribution and brain PET imaging with [18F]AV-45, a novel amyloid imaging agent--a pilot study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain; Case-Control Studies; Ethylene Glycols; Female; Fluorescent Dyes; Fluorine Radioisotopes; Humans; Male; Middle Aged; Pilot Projects; Positron-Emission Tomography; Radiometry; Thiazoles | 2010 |
18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Cognition Disorders; Diagnostic Imaging; Fluorodeoxyglucose F18; Humans; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Sensitivity and Specificity; Thiazoles | 2010 |
A modified method of 3D-SSP analysis for amyloid PET imaging using [¹¹C]BF-227.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzoxazoles; Carbon Radioisotopes; Case-Control Studies; Cognitive Dysfunction; Female; Humans; Imaging, Three-Dimensional; Male; Plaque, Amyloid; Positron-Emission Tomography; Reference Standards; Thiazoles | 2011 |
Mechanism of amyloid removal in patients with Alzheimer disease treated with gantenerumab.
Topics: Aged; Alzheimer Disease; Alzheimer Vaccines; Amyloid beta-Peptides; Aniline Compounds; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Brain Chemistry; Cell Count; Cohort Studies; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunoglobulin G; Injections, Intravenous; Male; Microglia; Middle Aged; Phagocytosis; Positron-Emission Tomography; Radiopharmaceuticals; Sample Size; Thiazoles | 2012 |
Comparison of 11C-PiB and 18F-florbetaben for Aβ imaging in ageing and Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Stilbenes; Thiazoles | 2012 |
Longitudinal imaging of Alzheimer pathology using [11C]PIB, [18F]FDDNP and [18F]FDG PET.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Case-Control Studies; Cognitive Dysfunction; Female; Humans; Longitudinal Studies; Male; Middle Aged; Nitriles; Positron-Emission Tomography; Stilbenes; Thiazoles; Time Factors | 2012 |
Impact of molecular imaging on the diagnostic process in a memory clinic.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Brain; Carbon Radioisotopes; Dementia; Diagnosis, Differential; Disease Progression; Early Diagnosis; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Follow-Up Studies; France; Frontotemporal Dementia; Humans; Lewy Body Disease; Male; Memory Disorders; Middle Aged; Molecular Imaging; Outpatient Clinics, Hospital; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Sensitivity and Specificity; Thiazoles; Treatment Outcome | 2013 |
Treatment of Alzheimer's disease with sabeluzole: functional and structural correlates.
Topics: Aged; Alzheimer Disease; Brain; Cognition; Double-Blind Method; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Thiazoles; Tomography, X-Ray Computed | 1997 |
912 other study(ies) available for thiazoles and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Clinical, Neuropsychological, and Neuroimaging Characteristics of Amyloid- positive vs. Amyloid-negative Patients with Clinically Diagnosed Alzheimer's Disease and Amnestic Mild Cognitive Impairment.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Atrophy; Brain; Cognitive Dysfunction; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2021 |
Novel Serum Biomarkers of Neurovascular Unit Associated with Cortical Amyloid Deposition.
Topics: Adenosine Triphosphate; Aged; Alzheimer Disease; Aniline Compounds; Biological Transport; Biomarkers; Cognitive Dysfunction; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2021 |
Patterns of Distribution of 18F-THK5351 Positron Emission Tomography in Alzheimer's Disease Continuum.
Topics: Aged; Alzheimer Disease; Aminopyridines; Amnesia; Aniline Compounds; Brain; Cognitive Dysfunction; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; Severity of Illness Index; tau Proteins; Thiazoles | 2022 |
Connectivity and Patterns of Regional Cerebral Blood Flow, Cerebral Glucose Uptake, and Aβ-Amyloid Deposition in Alzheimer's Disease (Early and Late-Onset) Compared to Normal Ageing.
Topics: Aging; Alzheimer Disease; Aniline Compounds; Brain; Cerebrovascular Circulation; Glucose; Humans; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Thiazoles | 2021 |
Comparison of
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Humans; Middle Aged; Multiple Sclerosis; Positron-Emission Tomography; Thiazoles; White Matter | 2022 |
Determination of optimal regularization factor in Bayesian penalized likelihood reconstruction of brain PET images using [
Topics: Algorithms; Alzheimer Disease; Aniline Compounds; Bayes Theorem; Brain; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Phantoms, Imaging; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Thiazoles | 2022 |
Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives.
Topics: Acetylcholinesterase; Alzheimer Disease; Amino Acids; Benzimidazoles; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Thiazoles | 2022 |
Synthesis, DFT Studies, Molecular Docking and Biological Activity Evaluation of Thiazole-Sulfonamide Derivatives as Potent Alzheimer's Inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Sulfonamides; Thiazoles | 2023 |
Discovery of thiazole salt AChE inhibitors and development of thiamine disulfide prodrugs targeting the central nervous system.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Humans; Mice; Mice, Inbred ICR; Prodrugs; Thiazoles | 2023 |
An activatable small-molecule fluorogenic probe for detection and quantification of beta-amyloid aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Fluorescence; Humans; Structure-Activity Relationship; Thiazoles | 2023 |
Increasing O-GlcNAcylation Attenuates tau Hyperphosphorylation and Behavioral Impairment in rTg4510 Tauopathy Mice.
Topics: Alzheimer Disease; Animals; Humans; Mice; Pyrans; Tauopathies; Thiazoles | 2023 |
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Topics: Aged; Alzheimer Disease; Aniline Compounds; Aphasia, Primary Progressive; Carbolines; Female; Frontotemporal Dementia; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; tau Proteins; Tauopathies; Thiazoles | 2019 |
Prognostic plasma protein panel for Aβ deposition in the brain in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Blood Chemical Analysis; Blood Proteins; Cognitive Dysfunction; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Positron-Emission Tomography; Predictive Value of Tests; Prognosis; Proteomics; Sensitivity and Specificity; Thiazoles | 2019 |
Tau deposition is associated with functional isolation of the hippocampus in aging.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Carbolines; Cognitive Aging; Contrast Media; Entorhinal Cortex; Executive Function; Female; Functional Neuroimaging; Hippocampus; Humans; Male; Memory, Episodic; Memory, Short-Term; Middle Aged; Neural Pathways; Neurofibrillary Tangles; Positron-Emission Tomography; tau Proteins; Temporal Lobe; Thiazoles; Young Adult | 2019 |
Automatic delineation algorithm of reference region for amyloid imaging based on kinetics.
Topics: Algorithms; Alzheimer Disease; Amyloid; Aniline Compounds; Carbon Radioisotopes; Dose-Response Relationship, Radiation; Electronic Data Processing; Humans; Image Interpretation, Computer-Assisted; Kinetics; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles; Time Factors | 2020 |
Evaluation of PiB visual interpretation with CSF Aβ and longitudinal SUVR in J-ADNI study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Cognitive Dysfunction; Cross-Sectional Studies; Databases, Factual; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Thiazoles; Time Factors | 2020 |
A New Serum Biomarker Set to Detect Mild Cognitive Impairment and Alzheimer's Disease by Peptidome Technology.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Cognitive Dysfunction; Female; Humans; Male; Mental Status and Dementia Tests; Middle Aged; Peptides; Positron-Emission Tomography; Predictive Value of Tests; Reference Values; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; tau Proteins; Thiazoles | 2020 |
Linear and nonlinear relationships between cognitive subdomains of ability discrepancy and Alzheimer's disease biomarkers.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Aptitude; Attention; Biomarkers; Brain; Carbon Radioisotopes; Cerebral Cortex; Cognition; Community Health Workers; Executive Function; Factor Analysis, Statistical; Female; Humans; Linear Models; Magnetic Resonance Imaging; Male; Memory, Episodic; Middle Aged; Neuropsychological Tests; Nonlinear Dynamics; Organ Size; Positron-Emission Tomography; Risk Assessment; Thiazoles | 2020 |
Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Carbon Radioisotopes; Cognitive Dysfunction; Female; Fluorine Radioisotopes; Humans; Isoquinolines; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neurofibrillary Tangles; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Prodromal Symptoms; tau Proteins; Thiazoles | 2020 |
GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer's Disease Models.
Topics: Allosteric Regulation; Alzheimer Disease; Animals; Behavior, Animal; Brain; CHO Cells; Cognition; Cricetulus; Cyclopropanes; Disease Models, Animal; Epilepsies, Myoclonic; Humans; Male; Mice; Mice, Inbred C57BL; Nitriles; Pyrazoles; Receptors, N-Methyl-D-Aspartate; Thiazoles | 2020 |
Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Brain; Carbolines; Case-Control Studies; Cerebral Cortex; Contrast Media; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Odds Ratio; Positron-Emission Tomography; Radiopharmaceuticals; tau Proteins; Thiazoles | 2020 |
Neuroticism, conscientiousness, and in vivo Alzheimer pathologies measured by amyloid PET and MRI.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cerebral Cortex; Cognitive Dysfunction; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroticism; Personality; Personality Inventory; Positron-Emission Tomography; Risk Factors; Thiazoles; White Matter | 2020 |
Longitudinal Amyloid-β PET in Atypical Alzheimer's Disease and Frontotemporal Lobar Degeneration.
Topics: Age of Onset; Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Disease Progression; Female; Frontotemporal Lobar Degeneration; Genotype; Humans; Longitudinal Studies; Male; Middle Aged; Positron-Emission Tomography; Sex Characteristics; Thiazoles | 2020 |
Ruthenium(iii) complexes containing thiazole-based ligands that modulate amyloid-β aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Cell Survival; Coordination Complexes; Crystallography, X-Ray; Humans; Ligands; Microscopy, Electron, Transmission; Peptide Fragments; Protein Aggregates; Rats; Ruthenium; Structure-Activity Relationship; Thiazoles | 2020 |
Comparison of T
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Glucose; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Pilot Projects; Positron-Emission Tomography; Thiazoles | 2020 |
Mapping the Binding Interface of PET Tracer Molecules and Alzheimer Disease Aβ Fibrils by Using MAS Solid-State NMR Spectroscopy.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Binding Sites; Carbon Isotopes; Fluorescent Dyes; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Positron-Emission Tomography; Thiazoles | 2020 |
The correlation of neuropsychological evaluation with 11C-PiB and 18F-FC119S amyloid PET in mild cognitive impairment and Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Cognitive Dysfunction; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Neuroimaging; Neuropsychological Tests; Positron Emission Tomography Computed Tomography; Pyridines; Radioactive Tracers; Thiazoles | 2020 |
Importance of γ-secretase in the regulation of liver X receptor and cellular lipid metabolism.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Astrocytes; Brain; Cell Line, Tumor; Cholesterol Esters; Diamines; Fibroblasts; Gene Deletion; Glycerides; Homeostasis; Humans; Lipid Droplets; Liver X Receptors; Mice; Mice, Knockout; Presenilins; Signal Transduction; Thiazoles; Transfection; Up-Regulation | 2020 |
Brain amyloid in virally suppressed HIV-associated neurocognitive disorder.
Topics: Aged; AIDS Dementia Complex; Alzheimer Disease; Amyloid; Aniline Compounds; Cognitive Dysfunction; Cohort Studies; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2020 |
Sex-driven modifiers of Alzheimer risk: A multimodality brain imaging study.
Topics: Adult; Aged; Alzheimer Disease; Aniline Compounds; Apolipoproteins E; Female; Fluorodeoxyglucose F18; Hormones; Humans; Life Style; Magnetic Resonance Imaging; Male; Menopause; Middle Aged; Multimodal Imaging; Neuroimaging; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Risk Factors; Sex Factors; Thiazoles | 2020 |
Effects of Chronic Masitinib Treatment in APPswe/PSEN1dE9 Transgenic Mice Modeling Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzamides; Cognition; Disease Models, Animal; Male; Mice, Transgenic; Piperidines; Presenilin-1; Pyridines; Synapses; Thiazoles | 2020 |
Rational design and biological evaluation of a new class of thiazolopyridyl tetrahydroacridines as cholinesterase and GSK-3 dual inhibitors for Alzheimer's disease.
Topics: Acetylcholinesterase; Acridines; Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Glycogen Synthase Kinase 3; Mice; Molecular Docking Simulation; Molecular Targeted Therapy; Morris Water Maze Test; Phosphorylation; Protein Conformation; tau Proteins; Thiazoles | 2020 |
Evaluation of choroidal thickness in prodromal Alzheimer's disease defined by amyloid PET.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Anthropometry; Area Under Curve; Carbon Radioisotopes; Case-Control Studies; Choroid; Cognitive Dysfunction; Cross-Sectional Studies; Disease Progression; Early Diagnosis; Female; Humans; Male; Neuroimaging; Observer Variation; Positron Emission Tomography Computed Tomography; Prodromal Symptoms; Radiopharmaceuticals; Reproducibility of Results; Thiazoles; Tomography, Optical Coherence | 2020 |
Design, Synthesis, and Structure-Activity Relationships of Thiazole Analogs as Anticholinesterase Agents for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Biological Transport; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Molecular Docking Simulation; Structure-Activity Relationship; Thiazoles | 2020 |
Relationship Between PET-Assessed Amyloid Burden and Visual and Verbal Episodic Memory Performance in Elderly Subjects.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cognition; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Humans; Male; Memory, Episodic; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2020 |
Plasma Glial Fibrillary Acidic Protein Levels Differ Along the Spectra of Amyloid Burden and Clinical Disease Stage.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloidogenic Proteins; Amyloidosis; Aniline Compounds; Brain; Cognitive Dysfunction; Cohort Studies; Cross-Sectional Studies; Ethylene Glycols; Female; Glial Fibrillary Acidic Protein; Humans; Male; Positron-Emission Tomography; Radiopharmaceuticals; tau Proteins; Thiazoles | 2020 |
Associations of quantitative susceptibility mapping with Alzheimer's disease clinical and imaging markers.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Basal Ganglia; Brain; Brain Mapping; Carbolines; Cerebral Cortex; Cognitive Dysfunction; Female; Globus Pallidus; Gray Matter; Humans; Iron; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Organ Size; Positron-Emission Tomography; Putamen; Radiopharmaceuticals; Substantia Nigra; Subthalamic Nucleus; tau Proteins; Thiazoles | 2021 |
Hippocampal subregional volume changes in elders classified using positron emission tomography-based Alzheimer's biomarkers of β-amyloid deposition and neurodegeneration.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Biomarkers; Carbon Radioisotopes; Cognitive Dysfunction; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Neuroimaging; Organ Size; Positron-Emission Tomography; Protein Aggregates; Radiopharmaceuticals; Thiazoles; White Matter | 2021 |
Automated Hippocampal Subfield Volumetric Analyses in Atypical Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Atrophy; CA1 Region, Hippocampal; CA2 Region, Hippocampal; CA3 Region, Hippocampal; Case-Control Studies; Dentate Gyrus; Female; Hippocampus; Humans; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Organ Size; Parahippocampal Gyrus; Positron-Emission Tomography; Thiazoles | 2020 |
Iterative framework for image registration and partial volume correction in brain positron emission tomography.
Topics: Alzheimer Disease; Aniline Compounds; Brain; Databases, Factual; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Neuroimaging; Positron-Emission Tomography; Thiazoles | 2020 |
Socioeconomic Status Mediates Racial Differences Seen Using the AT(N) Framework.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Black or African American; Brain; Carbolines; Cerebral Small Vessel Diseases; Ethylene Glycols; Female; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Male; Mediation Analysis; Middle Aged; Neuroimaging; Positron-Emission Tomography; Radiopharmaceuticals; Social Class; tau Proteins; Thiazoles; White | 2021 |
Severe Obstructive Sleep Apnea and Increased Cortical Amyloid-β Deposition.
Topics: Adult; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cerebral Cortex; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Radiopharmaceuticals; Severity of Illness Index; Sleep Apnea, Obstructive; Thiazoles | 2021 |
Diagnostic Accuracy of Amyloid versus
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Brain; DNA-Binding Proteins; Female; Fluorodeoxyglucose F18; Frontotemporal Dementia; Frontotemporal Lobar Degeneration; Humans; Male; Middle Aged; Pick Disease of the Brain; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Sensitivity and Specificity; tau Proteins; Thiazoles | 2021 |
Association of
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Aphasia, Primary Progressive; Apolipoprotein E4; Carbolines; Cerebral Cortex; Female; Frontal Lobe; Genotype; Humans; Magnetic Resonance Imaging; Male; Mental Status and Dementia Tests; Middle Aged; Occipital Lobe; Parietal Lobe; Phenotype; Positron-Emission Tomography; Radiopharmaceuticals; Retrospective Studies; tau Proteins; Temporal Lobe; Thiazoles; Visual Pathways | 2021 |
OGA Inhibition Alters Energetics and Nutrient Sensing in Alzheimer's Disease Cytoplasmic Hybrids.
Topics: Acetylation; Acetylglucosamine; Aged; Aged, 80 and over; Alzheimer Disease; beta-N-Acetylhexosaminidases; Cell Line, Tumor; Cell Respiration; Energy Metabolism; Enzyme Inhibitors; Female; Glycolysis; Humans; Hybrid Cells; In Vitro Techniques; Male; Mitochondria; Neurons; Pyrans; Sirtuin 3; Stress, Physiological; Thiazoles | 2020 |
Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Glycogen Synthase Kinase 3 beta; Humans; Molecular Structure; Neuroprotective Agents; Protein Kinase Inhibitors; Pyridines; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2021 |
Design, synthesis and biological evaluation of new benzoxazolone/benzothiazolone derivatives as multi-target agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Benzoxazoles; Butyrylcholinesterase; Cell Proliferation; Cells, Cultured; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Horses; Humans; Mice; Molecular Structure; Neuroprotective Agents; Protein Aggregates; Structure-Activity Relationship; Thiazoles | 2021 |
Non-invasive Standardised Uptake Value for Verification of the Use of Previously Validated Reference Region for [
Topics: Aged; Alzheimer Disease; Aniline Compounds; Brain; Carbolines; Case-Control Studies; Female; Fluorine Radioisotopes; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; tau Proteins; Thiazoles; Tissue Distribution | 2021 |
Modeling autosomal dominant Alzheimer's disease with machine learning.
Topics: Adult; Alzheimer Disease; Amyloid; Aniline Compounds; Atrophy; Female; Fluorodeoxyglucose F18; Humans; Machine Learning; Magnetic Resonance Imaging; Male; Mutation; Positron-Emission Tomography; Thiazoles | 2021 |
Clinical impact of 11C-Pittsburgh compound-B positron emission tomography in addition to magnetic resonance imaging and single-photon emission computed tomography on diagnosis of mild cognitive impairment to Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Cognitive Dysfunction; Female; Humans; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2021 |
Test-Retest Variability of Relative Tracer Delivery Rate as Measured by [
Topics: Adult; Aged; Alzheimer Disease; Aniline Compounds; Cerebrovascular Circulation; Cognitive Dysfunction; Female; Gray Matter; Humans; Image Processing, Computer-Assisted; Linear Models; Male; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles; Water | 2021 |
Mitochondrial complex I abnormalities is associated with tau and clinical symptoms in mild Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminopyridines; Aniline Compounds; Benzothiazoles; Brain Chemistry; Carbon Radioisotopes; Electron Transport Complex I; Entorhinal Cortex; Female; Fluorine Radioisotopes; Humans; Magnetic Resonance Imaging; Male; Mental Status and Dementia Tests; Middle Aged; Neuroimaging; Positron-Emission Tomography; Pyridazines; Pyridines; Radiopharmaceuticals; Severity of Illness Index; Symptom Assessment; tau Proteins; Thiazoles | 2021 |
JWX-A0108, a positive allosteric modulator of α7 nAChR, attenuates cognitive deficits in APP/PS1 mice by suppressing NF-κB-mediated inflammation.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Cognition Disorders; Disease Models, Animal; Inflammation; Mice; Mice, Transgenic; Morris Water Maze Test; NF-kappa B; Pyrimidines; Thiazoles | 2021 |
Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cohort Studies; Female; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2021 |
Head-to-head comparison of 11C-PiB and 18F-FC119S for Aβ imaging in healthy subjects, mild cognitive impairment patients, and Alzheimer's disease patients.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Cognitive Dysfunction; Female; Fluorine Radioisotopes; Healthy Volunteers; Humans; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2017 |
Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Cognitive Dysfunction; Cross-Sectional Studies; Female; Humans; Male; Peptide Fragments; Plaque, Amyloid; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Thiazoles | 2017 |
MRI-visible perivascular space location is associated with Alzheimer's disease independently of amyloid burden.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Apolipoprotein E4; Cerebral Amyloid Angiopathy; Cerebral Arteries; Cerebral Veins; Cognition Disorders; Echo-Planar Imaging; Female; Humans; Male; Neuroimaging; Positron-Emission Tomography; Prospective Studies; Thiazoles; White Matter | 2017 |
Metabolic network failures in Alzheimer's disease: A biochemical road map.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amino Acids; Amyloid beta-Peptides; Aniline Compounds; Cognitive Dysfunction; Cohort Studies; Cross-Sectional Studies; Fasting; Female; Humans; Male; Metabolic Diseases; Metabolic Networks and Pathways; Metabolomics; Peptide Fragments; Phosphatidylcholines; Sphingomyelins; tau Proteins; Thiazoles | 2017 |
Relationships among Cortical Glutathione Levels, Brain Amyloidosis, and Memory in Healthy Older Adults Investigated In Vivo with
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloidosis; Aniline Compounds; Brain; Cohort Studies; Female; Glutathione; Healthy Volunteers; Humans; Male; Positron-Emission Tomography; Proton Magnetic Resonance Spectroscopy; Thiazoles | 2017 |
Memory performance-related dynamic brain connectivity indicates pathological burden and genetic risk for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Apolipoprotein E4; Brain; Female; Follow-Up Studies; Genetic Predisposition to Disease; Heterozygote; Humans; Magnetic Resonance Imaging; Male; Memory; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Rest; Thiazoles | 2017 |
Memory self-awareness in the preclinical and prodromal stages of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Awareness; Brain; Cognitive Dysfunction; Cost of Illness; Cross-Sectional Studies; Diagnostic Self Evaluation; Disease Progression; Female; Humans; Male; Memory; Mental Status and Dementia Tests; Middle Aged; Positron-Emission Tomography; Prodromal Symptoms; Radiopharmaceuticals; Thiazoles | 2017 |
Evaluation of Amyloid Protective Factors and Alzheimer Disease Neurodegeneration Protective Factors in Elderly Individuals.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Female; Humans; Magnetic Resonance Imaging; Male; Neurodegenerative Diseases; Positron-Emission Tomography; Protective Factors; Risk Factors; Thiazoles | 2017 |
Habitual exercise levels are associated with cerebral amyloid load in presymptomatic autosomal dominant Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Apolipoproteins E; Brain; Cohort Studies; Cross-Sectional Studies; Exercise; Female; Genotype; Humans; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Peptide Fragments; Positron-Emission Tomography; Presenilin-1; Presenilin-2; Surveys and Questionnaires; tau Proteins; Thiazoles | 2017 |
Neuroimaging biomarkers and impaired olfaction in cognitively normal individuals.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Cerebral Cortex; Early Diagnosis; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Olfaction Disorders; Olfactory Perception; Positron-Emission Tomography; Thiazoles | 2017 |
Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Cerebral Cortex; Cross-Sectional Studies; Female; Fluorine Radioisotopes; Humans; Male; Positron-Emission Tomography; tau Proteins; Thiazoles | 2017 |
Brain inflammation accompanies amyloid in the majority of mild cognitive impairment cases due to Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Case-Control Studies; Cerebral Cortex; Cognitive Dysfunction; Disease Progression; Encephalitis; Female; Humans; Isoquinolines; Male; Microglia; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2017 |
Functional network integrity presages cognitive decline in preclinical Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cognitive Dysfunction; Connectome; Disease Progression; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net; Positron-Emission Tomography; Prodromal Symptoms; Prognosis; Thiazoles | 2017 |
Applicability of [
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Carbon Radioisotopes; Disease Models, Animal; Female; Follow-Up Studies; Humans; Liposomes; Male; Mice, Transgenic; Nanoparticles; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2017 |
Heme oxygenase-1 derived carbon monoxide suppresses Aβ
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Antioxidants; Astrocytes; Carbon Monoxide; Heme Oxygenase (Decyclizing); Homeostasis; Neurons; Nitric Oxide; Peptide Fragments; Peroxynitrous Acid; Rats; Rats, Wistar; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2017 |
Multimodal imaging Gd-nanoparticles functionalized with Pittsburgh compound B or a nanobody for amyloid plaques targeting.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Diabetes Mellitus, Type 2; Gadolinium; Humans; Immunohistochemistry; Islet Amyloid Polypeptide; Mice; Multimodal Imaging; Nanoparticles; Plaque, Amyloid; Single-Domain Antibodies; Thiazoles | 2017 |
Mitochondrion to endoplasmic reticulum apposition length in zebrafish embryo spinal progenitors is unchanged in response to perturbations associated with Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Body Size; Diamines; Embryo, Nonmammalian; Endoplasmic Reticulum; Humans; Mice; Microscopy, Electron, Transmission; Mitochondria; Oligonucleotides, Antisense; Presenilin-1; Presenilin-2; Sodium Azide; Spine; Stem Cells; Thiazoles; Zebrafish; Zebrafish Proteins | 2017 |
A Cross-Validation of FDG- and Amyloid-PET Biomarkers in Mild Cognitive Impairment for the Risk Prediction to Dementia due to Alzheimer's Disease in a Clinical Setting.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Biomarkers; Cognitive Dysfunction; Dementia; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; ROC Curve; Thiazoles | 2017 |
Upward drift in cerebrospinal fluid amyloid β 42 assay values for more than 10 years.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Female; Humans; Longitudinal Studies; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; ROC Curve; tau Proteins; Thiazoles | 2018 |
Cognitive decline and brain amyloid-β accumulation across 3 years in adults with Down syndrome.
Topics: Adult; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Cognition; Cognitive Dysfunction; Down Syndrome; Executive Function; Female; Humans; Male; Memory, Episodic; Middle Aged; Phenanthrolines; Positron-Emission Tomography; Thiazoles; Time Factors | 2017 |
Topics: Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Apolipoproteins E; Basal Ganglia; Benzothiazoles; Female; Genotype; Humans; Male; Middle Aged; Mutation; Positron-Emission Tomography; Presenilin-1; Presenilin-2; Thiazoles | 2017 |
Microvascular ultrastructural changes precede cognitive impairment in the murine APPswe/PS1dE9 model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Capillaries; Cerebral Cortex; Cognitive Dysfunction; Disease Models, Animal; Exploratory Behavior; Intussusception; Kidney Glomerulus; Liver; Male; Memory, Short-Term; Mice, Transgenic; Microvessels; Plaque, Amyloid; Spleen; Thiazoles | 2017 |
Urine AD7c-NTP Predicts Amyloid Deposition and Symptom of Agitation in Patients with Alzheimer's Disease and Mild Cognitive Impairment.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Area Under Curve; Cognitive Dysfunction; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Tissue Proteins; Neuropsychological Tests; Positron-Emission Tomography; Predictive Value of Tests; Psychiatric Status Rating Scales; Radioisotopes; Thiazoles | 2017 |
Associations of thyroid hormone serum levels with in-vivo Alzheimer's disease pathologies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Benzothiazoles; Biomarkers; Brain; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Thiazoles; Thyroid Hormones; Thyrotropin | 2017 |
Decreased Glucose Metabolism in Medial Prefrontal Areas is Associated with Nutritional Status in Patients with Prodromal and Early Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Cognition Disorders; Female; Glucose Metabolism Disorders; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nutritional Status; Positron-Emission Tomography; Prefrontal Cortex; Prodromal Symptoms; Psychiatric Status Rating Scales; Thiazoles | 2017 |
Binding of Thioflavin T and Related Probes to Polymorphic Models of Amyloid-β Fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Fluorescent Dyes; Humans; Models, Molecular; Peptide Fragments; Protein Binding; Protein Conformation, beta-Strand; Thermodynamics; Thiazoles | 2017 |
Comparison of [
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Cognition; Dementia; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Thiazoles; White Matter | 2017 |
Generation of Clickable Pittsburgh Compound B for the Detection and Capture of β-Amyloid in Alzheimer's Disease Brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Click Chemistry; Humans; Magnets; Microspheres; Peptide Fragments; Protein Aggregates; Thiazoles | 2017 |
Neuroinflammation Appears Early on PET Imaging and Then Plateaus in a Mouse Model of Alzheimer Disease.
Topics: Alzheimer Disease; Aniline Compounds; Animals; Benzothiazoles; Brain; Carbazoles; Disease Models, Animal; Female; Inflammation; Longitudinal Studies; Mice; Positron-Emission Tomography; Thiazoles | 2018 |
Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Aphasia, Primary Progressive; Benzothiazoles; Brain; Carbolines; Carbon Radioisotopes; Case-Control Studies; Cognitive Dysfunction; Female; Fluorine Radioisotopes; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Regression Analysis; tau Proteins; Thiazoles | 2017 |
11C-PIB PET image analysis for Alzheimer's diagnosis using weighted voting ensembles.
Topics: Alzheimer Disease; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Cognitive Dysfunction; Humans; Positron-Emission Tomography; Thiazoles | 2017 |
The first case series of Chinese patients in Hong Kong with familial Alzheimer's disease compared with those with biomarker-confirmed sporadic late-onset Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Asian People; Biomarkers; Delayed Diagnosis; Female; Genetic Predisposition to Disease; Hong Kong; Humans; Male; Middle Aged; Positron-Emission Tomography; Retrospective Studies; Thiazoles | 2017 |
[
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Dogs; Humans; Magnetite Nanoparticles; Mice; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2017 |
Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Positron-Emission Tomography; Psychiatric Status Rating Scales; Republic of Korea; Retrospective Studies; tau Proteins; Thiazoles | 2017 |
Pittsburgh Compound B and AV-1451 positron emission tomography assessment of molecular pathologies of Alzheimer's disease in progressive supranuclear palsy.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Brain; Carbolines; Female; Humans; Male; Middle Aged; Pathology, Molecular; Positron-Emission Tomography; Supranuclear Palsy, Progressive; tau Proteins; Thiazoles | 2018 |
Neuroprotective, Neurogenic, and Amyloid Beta Reducing Effect of a Novel Alpha 2-Adrenoblocker, Mesedin, on Astroglia and Neuronal Progenitors upon Hypoxia and Glutamate Exposure.
Topics: Adrenergic alpha-2 Receptor Antagonists; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Biomarkers, Pharmacological; Cell Survival; Dioxanes; Glutamic Acid; Hypoxia; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Neurons; Neuroprotective Agents; Primary Cell Culture; Thiazoles | 2017 |
Small molecule SUMOylation activators are novel neuroprotective agents.
Topics: Alzheimer Disease; Benzothiazoles; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Structure; Neuroprotective Agents; Parkinson Disease; Quinolines; Small Molecule Libraries; Small Ubiquitin-Related Modifier Proteins; Stroke; Structure-Activity Relationship; Sumoylation; Thiazoles | 2018 |
Tau burden and the functional connectome in Alzheimer's disease and progressive supranuclear palsy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain Mapping; Carbolines; Connectome; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Oxygen; Positron-Emission Tomography; Rest; Supranuclear Palsy, Progressive; tau Proteins; Thiazoles | 2018 |
Fibre-specific white matter reductions in Alzheimer's disease and mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain; Cognitive Dysfunction; Cross-Sectional Studies; Female; Humans; Imaging, Three-Dimensional; Male; Mental Status Schedule; Nerve Fibers; Positron-Emission Tomography; Thiazoles; White Matter | 2018 |
Circadian Rest-Activity Pattern Changes in Aging and Preclinical Alzheimer Disease.
Topics: Actigraphy; Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Chronobiology Disorders; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Statistics, Nonparametric; tau Proteins; Thiazoles | 2018 |
Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study.
Topics: Adult; Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Brain; Brain Mapping; Family Health; Female; Fluorodeoxyglucose F18; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Presenilin-1; Presenilin-2; Statistics, Nonparametric; Thiazoles | 2018 |
Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease.
Topics: Adult; Age Factors; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Carbolines; Cognition Disorders; Colombia; Cross-Sectional Studies; Female; Humans; Magnetic Resonance Imaging; Male; Mental Status and Dementia Tests; Middle Aged; Mutation; Neuropsychological Tests; Positron-Emission Tomography; Presenilin-1; tau Proteins; Thiazoles | 2018 |
Proximity to Parental Symptom Onset and Amyloid-β Burden in Sporadic Alzheimer Disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Asymptomatic Diseases; Cohort Studies; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Parents; Peptide Fragments; Positron-Emission Tomography; Sex Factors; Thiazoles | 2018 |
Thiamine diphosphate reduction strongly correlates with brain glucose hypometabolism in Alzheimer's disease, whereas amyloid deposition does not.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Brain; Disease Models, Animal; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Positron-Emission Tomography; Presenilin-1; Psychiatric Status Rating Scales; Thiamine; Thiamine Pyrophosphate; Thiazoles | 2018 |
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Aggregates; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2018 |
Cerebrospinal fluid biomarkers measured by Elecsys assays compared to amyloid imaging.
Topics: Aged; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Cohort Studies; Female; Humans; Immunoassay; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Radiopharmaceuticals; tau Proteins; Thiazoles | 2018 |
Amyloid PET Imaging: Standardization and Integration with Other Alzheimer's Disease Biomarkers.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Carbon Radioisotopes; Fluorodeoxyglucose F18; Humans; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Stilbenes; Thiazoles | 2018 |
Electromagnetic signatures of the preclinical and prodromal stages of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Brain; Brain Mapping; Cognitive Dysfunction; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Magnetoencephalography; Male; Neuropsychological Tests; Positron-Emission Tomography; Prodromal Symptoms; Psychiatric Status Rating Scales; Thiazoles | 2018 |
Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Brain Mapping; Cognition Disorders; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Models, Neurological; Neural Pathways; Positron-Emission Tomography; Thiazoles | 2018 |
Regional association of pCASL-MRI with FDG-PET and PiB-PET in people at risk for autosomal dominant Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Brain; Cerebrovascular Circulation; Cross-Sectional Studies; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Presenilin-1; Presenilin-2; Spin Labels; Thiazoles; Young Adult | 2018 |
Metabolic brain networks in aging and preclinical Alzheimer's disease.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Brain; Correlation of Data; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles; Young Adult | 2018 |
Distinct dynamic profiles of microglial activation are associated with progression of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Brain Mapping; Disease Progression; Female; Hippocampus; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Mental Status Schedule; Microglia; Middle Aged; Neuropsychological Tests; Organoplatinum Compounds; Positron-Emission Tomography; Prospective Studies; Pyrazoles; Pyrimidines; Radiopharmaceuticals; Thiazoles | 2018 |
Negative 11C-PIB PET Predicts Lack of Alzheimer's Disease Pathology in Postmortem Examination.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Benzothiazoles; Brain; DNA-Binding Proteins; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Sequestosome-1 Protein; tau Proteins; Thiazoles | 2018 |
Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Brain; Cross-Sectional Studies; Female; Genotype; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2018 |
Subthreshold Amyloid Predicts Tau Deposition in Aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Carbolines; Cerebral Cortex; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Male; Memory Disorders; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Reference Values; tau Proteins; Thiazoles | 2018 |
Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Asymptomatic Diseases; Brain; Case-Control Studies; Cognitive Dysfunction; Female; Humans; Longitudinal Studies; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Prevalence; Proportional Hazards Models; Prospective Studies; Thiazoles; United States | 2018 |
The correlation between striatal and cortical binding ratio of
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Cerebral Cortex; Cognitive Dysfunction; Corpus Striatum; Female; Frontotemporal Lobar Degeneration; Humans; Lewy Body Disease; Male; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Retrospective Studies; Thiazoles | 2018 |
Reduced penetrance of the PSEN1 H163Y autosomal dominant Alzheimer mutation: a 22-year follow-up study.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Genetic Testing; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Neuropsychological Tests; Positron-Emission Tomography; Presenilin-1; Siblings; Thiazoles | 2018 |
Adaptive template generation for amyloid PET using a deep learning approach.
Topics: Algorithms; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Cognitive Dysfunction; Deep Learning; Female; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Radiopharmaceuticals; Supervised Machine Learning; Thiazoles | 2018 |
Beta-amyloid and Cortical Thickness Reveal Racial Disparities in Preclinical Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Benzothiazoles; Black or African American; Brain; Cerebral Cortex; Correlation of Data; Female; Hispanic or Latino; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Thiazoles; White People | 2017 |
Spatial Patterns of Hypometabolism and Amyloid Deposition in Variants of Alzheimer's Disease Corresponding to Brain Networks: a Prospective Cohort Study.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain; Brain Diseases, Metabolic; Carbon Radioisotopes; Case-Control Studies; Cohort Studies; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles; Time Factors; Tissue Distribution | 2019 |
Rhenium Complexes of Bis(benzothiazole)-Based Tetraarylethylenes as Selective Luminescent Probes for Amyloid Fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Chelating Agents; Humans; Ligands; Luminescence; Peptide Fragments; Rhenium; Thiazoles | 2018 |
Amyloid deposition and CBF patterns predict conversion of mild cognitive impairment to dementia.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Cognitive Dysfunction; Disease Progression; Female; Follow-Up Studies; Humans; Male; Neuropsychological Tests; Perfusion Imaging; Phenanthrolines; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Retrospective Studies; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2018 |
Amyloid and Tau Positron Emission Tomography in Suggested Diabetesrelated Dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Dementia; Diabetes Mellitus, Type 2; Female; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; tau Proteins; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2018 |
Discovery and validation of autosomal dominant Alzheimer's disease mutations.
Topics: Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Cell Line, Tumor; Computational Biology; DNA Mutational Analysis; Family Health; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Neuroblastoma; Peptide Fragments; Positron-Emission Tomography; Presenilin-1; Presenilin-2; Reproducibility of Results; Thiazoles; Transfection | 2018 |
Crossed Cerebellar Diaschisis in Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Cerebellum; Cognition Disorders; Depression; Female; Fluorodeoxyglucose F18; Functional Laterality; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Retrospective Studies; Thiazoles | 2018 |
A Novel Magnetic Nanoparticle for Early Detection of Amyloid Plaques in Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Cell Line; Disease Models, Animal; Dogs; Early Diagnosis; Female; Humans; Immunohistochemistry; Madin Darby Canine Kidney Cells; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Positron-Emission Tomography; Surface-Active Agents; Thiazoles | 2018 |
Incident cognitive impairment: longitudinal changes in molecular, structural and cognitive biomarkers.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Biomarkers; Cognitive Dysfunction; Female; Genotype; Humans; Incidence; Kaplan-Meier Estimate; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Psychometrics; Thiazoles | 2018 |
Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer's Disease.
Topics: Adult; Age of Onset; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Cognitive Dysfunction; Cross-Sectional Studies; Female; Genetic Predisposition to Disease; Humans; Magnetic Resonance Imaging; Male; Mental Recall; Positron-Emission Tomography; Thiazoles; Young Adult | 2019 |
Blood acetylcholinesterase level is a potential biomarker for the early detection of cerebral amyloid deposition in cognitively normal individuals.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Cognition; Early Diagnosis; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles | 2019 |
Investigation of the quantitative accuracy of low-dose amyloid and tau PET imaging.
Topics: Aged; Algorithms; Alzheimer Disease; Aminopyridines; Amyloid; Aniline Compounds; Artifacts; Benzothiazoles; Brain; Case-Control Studies; Female; Humans; Image Processing, Computer-Assisted; Male; Movement; Positron-Emission Tomography; Quinolines; Radiation Dosage; tau Proteins; Thiazoles; Young Adult | 2018 |
Multisite study of the relationships between antemortem [
Topics: Aged; Alzheimer Disease; Aniline Compounds; Autopsy; Female; Humans; Male; Neuropathology; Plaque, Amyloid; Positron-Emission Tomography; Retrospective Studies; Thiazoles | 2019 |
Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloidogenic Proteins; Aniline Compounds; Cerebral Small Vessel Diseases; Cognitive Dysfunction; Female; Humans; Male; Middle Aged; Occipital Lobe; Positron-Emission Tomography; Thiazoles | 2018 |
Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Dementia, Vascular; Female; Humans; Linear Models; Magnetic Resonance Imaging; Male; Microvessels; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Retina; Risk Factors; Thiazoles; White Matter | 2019 |
Nonlinear Distributional Mapping (NoDiM) for harmonization across amyloid-PET radiotracers.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Brain; Datasets as Topic; Ethylene Glycols; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Models, Theoretical; Neuroimaging; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2019 |
A Comparison of Partial Volume Correction Techniques for Measuring Change in Serial Amyloid PET SUVR.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Aniline Compounds; Cross-Sectional Studies; Female; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Reproducibility of Results; Thiazoles | 2019 |
The relevance of cerebrospinal fluid α-synuclein levels to sporadic and familial Alzheimer's disease.
Topics: Aged; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Apolipoproteins E; Brain; Cognitive Dysfunction; Cohort Studies; Cross-Sectional Studies; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Peptide Fragments; Positron-Emission Tomography; ROC Curve; Statistics, Nonparametric; tau Proteins; Thiazoles | 2018 |
Plasma Aβ42/40 Ratio Detects Early Stages of Alzheimer's Disease and Correlates with CSF and Neuroimaging Biomarkers in the AB255 Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Biomarkers; Case-Control Studies; Cognitive Dysfunction; Cross-Sectional Studies; Early Diagnosis; Female; Fluorodeoxyglucose F18; Genotype; Humans; Male; Neuroimaging; Peptide Fragments; Phosphorylation; Plaque, Amyloid; Positron-Emission Tomography; Prodromal Symptoms; tau Proteins; Thiazoles | 2019 |
Anticoagulation Therapy for Atrial Fibrillation in Patients With Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Anticoagulants; Atrial Fibrillation; Cost-Benefit Analysis; Dabigatran; Disease Progression; Health Care Costs; Humans; Pyrazoles; Pyridines; Pyridones; Quality-Adjusted Life Years; Rivaroxaban; Stroke; Thiazoles; Warfarin | 2018 |
The influence of β-amyloid on [
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Aphasia, Primary Progressive; Brain; Carbolines; Contrast Media; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Semantics; Thiazoles | 2019 |
Relative cerebral flow from dynamic PIB scans as an alternative for FDG scans in Alzheimer's disease PET studies.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Brain; Carbon Radioisotopes; Case-Control Studies; Cerebrovascular Circulation; Cognitive Dysfunction; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2019 |
Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer's Disease Dementia.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apathy; Cognitive Dysfunction; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Surveys and Questionnaires; tau Proteins; Thiazoles | 2019 |
New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Models, Molecular; Molecular Conformation; Molecular Structure; Protein Aggregates; Protein Aggregation, Pathological; Structure-Activity Relationship; Tacrine; Thiazoles | 2019 |
Dynamic
Topics: Adult; Aged; Algorithms; Alzheimer Disease; Aniline Compounds; Area Under Curve; Brain; Case-Control Studies; Cerebrospinal Fluid; Cognitive Dysfunction; Databases, Factual; Female; Homeostasis; Humans; Kinetics; Magnetic Resonance Imaging; Male; Middle Aged; Multiple Sclerosis; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles | 2019 |
The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease.
Topics: Age Factors; Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Aphasia, Primary Progressive; Atrophy; Brain; Cohort Studies; Female; Gray Matter; Humans; Male; Positron-Emission Tomography; tau Proteins; Thiazoles | 2019 |
Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Astrocytes; Cognition; Culture Media, Conditioned; Disease Models, Animal; Gene Expression Regulation; Genes, Reporter; Hippocampus; Humans; Liver X Receptors; Luciferases; Male; Memory, Short-Term; Mice; Mice, Transgenic; Microglia; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Sargassum; Signal Transduction; Stigmasterol; Thiazoles | 2019 |
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antiparasitic Agents; Cells, Cultured; Disease Models, Animal; Humans; Learning; Memory Disorders; Mice; Nitro Compounds; Thiazoles | 2019 |
Alzheimer disease biomarkers may aid in the prognosis of MCI cases initially reverted to normal.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Cognitive Dysfunction; Dementia; Disease Progression; Ethylene Glycols; Female; Humans; Male; Middle Aged; Peptide Fragments; Plaque, Amyloid; Positron-Emission Tomography; Prognosis; Recurrence; Remission, Spontaneous; Risk Assessment; tau Proteins; Thiazoles | 2019 |
Biopathological Significance of Early-Phase Amyloid Imaging in the Spectrum of Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Carbon Radioisotopes; Cognitive Dysfunction; Cross-Sectional Studies; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2019 |
Subcortical amyloid load is associated with shape and volume in cognitively normal individuals.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Female; Globus Pallidus; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Neuroimaging; Positron-Emission Tomography; Thalamus; Thiazoles | 2019 |
Pharmacological investigation of quinoxaline-bisthiazoles as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents; Antioxidants; Aspartic Acid Endopeptidases; Binding Sites; Brain; Catalytic Domain; Drug Design; Edema; Humans; Ligands; Maze Learning; Molecular Docking Simulation; Neuroprotective Agents; Protease Inhibitors; Quinoxalines; Rats; Structure-Activity Relationship; Thiazoles | 2019 |
Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Autopsy; Brain; Female; Fluorine Radioisotopes; Humans; Magnetic Resonance Imaging; Male; Neurodegenerative Diseases; Neurofibrillary Tangles; Neuroimaging; Neuropathology; Plaque, Amyloid; Positron-Emission Tomography; Prospective Studies; Thiazoles | 2019 |
Sleep as a Potential Biomarker of Tau and β-Amyloid Burden in the Human Brain.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Carbolines; Carbon Radioisotopes; Electroencephalography; Female; Fluorine Radioisotopes; Humans; Magnetic Resonance Imaging; Male; Models, Neurological; Nerve Tissue Proteins; Polysomnography; Positron-Emission Tomography; Predictive Value of Tests; Prognosis; Radiopharmaceuticals; Sleep Disorders, Intrinsic; Sleep Stages; tau Proteins; Temporal Lobe; Thiazoles | 2019 |
Associations of Neprilysin Activity in CSF with Biomarkers for Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Biomarkers; Brain; Brain Chemistry; Carbon Radioisotopes; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Humans; Male; Mental Status and Dementia Tests; Middle Aged; Neprilysin; Neuroimaging; Peptide Fragments; Positron-Emission Tomography; Radiopharmaceuticals; tau Proteins; Thiazoles | 2019 |
Cognitive reserve and clinical progression in Alzheimer disease: A paradoxical relationship.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Case-Control Studies; Cognitive Dysfunction; Cognitive Reserve; Contrast Media; Disease Progression; Ethylene Glycols; Executive Function; Female; Gray Matter; Humans; Male; Memory; Middle Aged; Organ Size; Peptide Fragments; Thiazoles; White Matter | 2019 |
Brain Amyloid PET Tracer Delivery is Related to White Matter Integrity in Patients with Mild Cognitive Impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain; Cerebrovascular Circulation; Cognitive Dysfunction; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles; White Matter | 2019 |
Determining clinically meaningful decline in preclinical Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Asymptomatic Diseases; Benzothiazoles; Brain; Cognitive Dysfunction; Contrast Media; Disease Progression; Ethylene Glycols; Female; Humans; Male; Mental Recall; Mental Status and Dementia Tests; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles; Time Factors; Trail Making Test | 2019 |
Differential effects of Down's syndrome and Alzheimer's neuropathology on default mode connectivity.
Topics: Adult; Alzheimer Disease; Amyloid; Aniline Compounds; Carbon Radioisotopes; Cerebral Cortex; Connectome; Cross-Sectional Studies; Down Syndrome; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2019 |
Amyloid imaging of dutch-type hereditary cerebral amyloid angiopathy carriers.
Topics: Adult; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Case-Control Studies; Cerebral Amyloid Angiopathy, Familial; Female; Functional Neuroimaging; Heterozygote; Humans; Male; Middle Aged; Neuroimaging; Positron-Emission Tomography; Thiazoles | 2019 |
Design, synthesis and structure-activity relationship of rhenium 2-arylbenzothiazoles as β-amyloid plaque binding agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Coordination Complexes; Drug Design; Humans; Organotechnetium Compounds; Peptide Fragments; Protein Binding; Radiography; Rhenium; Structure-Activity Relationship; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2013 |
Disclosure of amyloid imaging results to research participants: has the time come?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomedical Research; Disclosure; Humans; Molecular Imaging; Positron-Emission Tomography; Reproducibility of Results; Thiazoles | 2013 |
White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloidosis; Aniline Compounds; Brain Mapping; Cerebral Cortex; Cognitive Dysfunction; Databases, Factual; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Fibers, Myelinated; Positron-Emission Tomography; Thiazoles | 2013 |
Cerebral amyloid angiopathy burden associated with leukoaraiosis: a positron emission tomography/magnetic resonance imaging study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Apolipoprotein E4; Cerebral Amyloid Angiopathy; Cognition Disorders; Female; Humans; Leukoaraiosis; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Statistics, Nonparametric; Thiazoles | 2013 |
Exploring the multifunctionality of thioflavin- and deferiprone-based molecules as acetylcholinesterase inhibitors for potential application in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzothiazoles; Binding, Competitive; Blood-Brain Barrier; Catalytic Domain; Cell Survival; Cholinesterase Inhibitors; Deferiprone; Humans; Kinetics; Ligands; Models, Molecular; Molecular Docking Simulation; Molecular Structure; Permeability; Prodrugs; Protein Binding; Pyridones; Thiazoles | 2013 |
Pathogenesis of cerebral microbleeds: In vivo imaging of amyloid and subcortical ischemic small vessel disease in 226 individuals with cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Cognition Disorders; Female; Humans; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Stroke, Lacunar; Thiazoles | 2013 |
Amyloid deposition in early onset versus late onset Alzheimer's disease.
Topics: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Apolipoprotein E4; Data Interpretation, Statistical; Female; Genotype; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Psychomotor Performance; Radiopharmaceuticals; Sample Size; Thiazoles | 2013 |
Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not β-amyloid in cognitively normal older individuals.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid; Analysis of Variance; Aniline Compounds; Biomarkers; Brain Mapping; Cognition Disorders; Female; Fluorodeoxyglucose F18; Humans; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Radioisotopes; Reproducibility of Results; Thiazoles | 2013 |
Association of plasma and cortical amyloid beta is modulated by APOE ε4 status.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Brain; Cerebral Cortex; Cognitive Dysfunction; Female; Humans; Male; Neuropsychological Tests; Peptide Fragments; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2014 |
Three-month stability of the CogState brief battery in healthy older adults, mild cognitive impairment, and Alzheimer's disease: results from the Australian Imaging, Biomarkers, and Lifestyle-rate of change substudy (AIBL-ROCS).
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Aniline Compounds; Association Learning; Australia; Case-Control Studies; Cognitive Dysfunction; Disease Progression; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Positron-Emission Tomography; Reaction Time; Reproducibility of Results; Thiazoles; Time Factors | 2013 |
Characterization of a single-chain variable fragment recognizing a linear epitope of aβ: a biotechnical tool for studies on Alzheimer's disease?
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Enzyme-Linked Immunosorbent Assay; Epitopes; Humans; Immunoglobulin G; Immunohistochemistry; Ligands; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Neurodegenerative Diseases; Permeability; Plasmids; Protein Binding; Sequence Alignment; Single-Chain Antibodies; Thiazoles | 2013 |
Resveratrol inhibits β-amyloid-induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Apoptosis; Calcium; Cell Survival; Flow Cytometry; Gene Expression Regulation; Homeostasis; L-Lactate Dehydrogenase; Neurodegenerative Diseases; Neurons; PC12 Cells; Peptide Fragments; Rats; Resveratrol; rho-Associated Kinases; Signal Transduction; Sirtuin 1; Stilbenes; Tetrazolium Salts; Thiazoles | 2013 |
Voxel-based analysis of amyloid-burden measured with [(11)C]PiB PET in a double transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Animals; Benzothiazoles; Carbon Radioisotopes; Disease Models, Animal; Female; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Positron-Emission Tomography; Regression Analysis; Signal Processing, Computer-Assisted; Thiazoles | 2013 |
Clinical profile of PiB-positive corticobasal syndrome.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Carbon Radioisotopes; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Activity; Neurodegenerative Diseases; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2013 |
A blood-based predictor for neocortical Aβ burden in Alzheimer's disease: results from the AIBL study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Chemokine CCL3; Cohort Studies; Cullin Proteins; Female; Humans; Interleukin-17; Male; Neocortex; Pancreatic Polypeptide; Positron-Emission Tomography; Predictive Value of Tests; ROC Curve; Thiazoles | 2014 |
Detection of brain amyloid β deposition in patients with neuropsychological impairment after traumatic brain injury: PET evaluation using Pittsburgh Compound-B.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Brain Injuries; Carbon Radioisotopes; Disease Progression; Female; Humans; Japan; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Prognosis; Thiazoles | 2013 |
Structural insights into Aβ42 oligomers using site-directed spin labeling.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Survival; Circular Dichroism; Electron Spin Resonance Spectroscopy; HeLa Cells; Humans; Microscopy, Electron, Transmission; PC12 Cells; Peptide Fragments; Protein Folding; Protein Structure, Secondary; Rats; Spin Labels; Tetrazolium Salts; Thiazoles; X-Ray Diffraction | 2013 |
Does a positive Pittsburgh Compound B scan in a patient with dementia equal Alzheimer disease?
Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cerebral Hemorrhage; Diagnosis, Differential; Fatal Outcome; Humans; Magnetic Resonance Imaging; Male; Memory Disorders; Neuropsychological Tests; Positron-Emission Tomography; Sensitivity and Specificity; Thiazoles | 2013 |
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Cognitive Dysfunction; Cohort Studies; Dextrans; Female; Genetic Association Studies; Genotype; HLA-D Antigens; Humans; Male; Microglia; Middle Aged; Monocytes; Peptide Fragments; Plaque, Amyloid; Polymorphism, Genetic; Radionuclide Imaging; Sialic Acid Binding Ig-like Lectin 3; Thiazoles; Young Adult | 2013 |
Molecular characterization of the hetero-assembly of β-amyloid peptide with islet amyloid polypeptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Amyloidosis; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Diabetes Mellitus, Type 2; Islet Amyloid Polypeptide; Kinetics; Microscopy, Electron, Transmission; Molecular Sequence Data; PC12 Cells; Peptide Fragments; Protein Binding; Protein Folding; Protein Multimerization; Rats; Spectrometry, Fluorescence; Thiazoles | 2014 |
Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Cyclin-Dependent Kinase 5; Diamines; Disease Models, Animal; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Injections, Intraperitoneal; Injections, Intraventricular; Injections, Subcutaneous; Learning; Male; Memory; Mice; Mice, Transgenic; Neuroprotective Agents; Phosphorylation; Presenilin-1; Protein Kinase Inhibitors; tau Proteins; Tauopathies; Thiazoles; Treatment Outcome | 2013 |
Implementation and validation of an adaptive template registration method for 18F-flutemetamol imaging data.
Topics: Adult; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Humans; Image Processing, Computer-Assisted; Middle Aged; Positron-Emission Tomography; Statistics as Topic; Thiazoles | 2013 |
Amyloid tracers detect multiple binding sites in Alzheimer's disease brain tissue.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Benzothiazoles; Binding Sites; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Peptide Fragments; Postmortem Changes; Radionuclide Imaging; Thiazoles; Tissue Distribution; Tritium | 2013 |
Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease.
Topics: Acetylcholine; Acetylcholinesterase; Aged; Alzheimer Disease; Aniline Compounds; Astrocytes; Butyrylcholinesterase; Calcium-Binding Proteins; Cells, Cultured; Cognition Disorders; Complement System Proteins; Cytokines; DNA-Binding Proteins; Female; Fluorodeoxyglucose F18; Glial Fibrillary Acidic Protein; Humans; Male; Mental Status Schedule; Microfilament Proteins; Neuropsychological Tests; Polymorphism, Single Nucleotide; Radionuclide Imaging; S100 Calcium Binding Protein beta Subunit; Thiazoles | 2013 |
Effects of APOE ε4 on brain amyloid, lacunar infarcts, and white matter lesions: a study among patients with subcortical vascular cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Brain; Cognition Disorders; Female; Genotype; Humans; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Fibers, Myelinated; Neuropsychological Tests; Prospective Studies; Radionuclide Imaging; Thiazoles; Vascular Diseases | 2013 |
BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Australia; Brain-Derived Neurotrophic Factor; Cognition Disorders; Female; Genotype; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Memory, Episodic; Methionine; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Thiazoles; Valine | 2013 |
In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease.
Topics: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Brain; Brain Mapping; Cognition Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Pyrimidines; Receptors, GABA; Statistics as Topic; Thiazoles | 2013 |
Diagnosed mild cognitive impairment due to Alzheimer's disease with PET biomarkers of beta amyloid and neuronal dysfunction.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Cerebral Cortex; Cognitive Dysfunction; Disease Progression; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Sensitivity and Specificity; Thiazoles | 2013 |
In vivo characterization of the early states of the amyloid-beta network.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Brain Mapping; Carbon Isotopes; Female; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neural Pathways; Oxygen; Positron-Emission Tomography; Thiazoles | 2013 |
Preclinical Alzheimer disease and risk of falls.
Topics: Accidental Falls; Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Cohort Studies; Early Diagnosis; Female; Follow-Up Studies; Humans; Male; Prospective Studies; Risk Factors; Thiazoles | 2013 |
Different β-amyloid binding patterns in Alzheimer and Parkinson diseases: it's the network!
Topics: Alzheimer Disease; Aniline Compounds; Female; Humans; Male; Parkinson Disease; Principal Component Analysis; Radionuclide Imaging; Thiazoles | 2013 |
Principal component analysis of PiB distribution in Parkinson and Alzheimer diseases.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Female; Humans; Male; Middle Aged; Parkinson Disease; Positron-Emission Tomography; Principal Component Analysis; Protein Binding; Thiazoles | 2013 |
Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Disease Models, Animal; Gliosis; Humans; Integrases; Membrane Glycoproteins; Mice; Mice, Transgenic; Nerve Degeneration; Neurons; Phenotype; Presenilin-1; Thiazoles | 2013 |
Longitudinal amyloid imaging in mouse brain with 11C-PIB: comparison of APP23, Tg2576, and APPswe-PS1dE9 mouse models of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Autoradiography; Benzothiazoles; Brain; Disease Models, Animal; Female; Longitudinal Studies; Male; Mice; Mice, Transgenic; Positron-Emission Tomography; Thiazoles | 2013 |
Distribution of amyloid burden differs between idiopathic normal pressure hydrocephalus and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Brain Mapping; Female; Functional Laterality; Humans; Hydrocephalus, Normal Pressure; Male; Peptide Fragments; Positron-Emission Tomography; Statistics, Nonparametric; Thiazoles | 2013 |
The helicase-primase inhibitor BAY 57-1293 reduces the Alzheimer's disease-related molecules induced by herpes simplex virus type 1.
Topics: Acyclovir; Alzheimer Disease; Amyloid beta-Peptides; Antiviral Agents; DNA Helicases; DNA Primase; Down-Regulation; Enzyme Inhibitors; Herpes Simplex; Herpesvirus 1, Human; Humans; Pyridines; Sulfonamides; tau Proteins; Thiazoles; Viral Proteins; Virus Replication | 2013 |
³H-deprenyl and ³H-PIB autoradiography show different laminar distributions of astroglia and fibrillar β-amyloid in Alzheimer brain.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Astrocytes; Autoradiography; Benzothiazoles; Bungarotoxins; Cerebral Cortex; Female; Hippocampus; Humans; Immunohistochemistry; Isoquinolines; Isotope Labeling; Male; Nicotine; Parasympathetic Nervous System; Radionuclide Imaging; Receptors, Nicotinic; Selegiline; Synaptic Transmission; Thiazoles | 2013 |
Apolipoprotein Ε ε4 frequency is increased among Chinese patients with frontotemporal dementia and Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Apolipoprotein E4; Asian People; China; Diagnostic and Statistical Manual of Mental Disorders; Female; Fluorodeoxyglucose F18; Frontotemporal Dementia; Gene Frequency; Genotype; Humans; Male; Middle Aged; Polymerase Chain Reaction; Positron-Emission Tomography; Radiopharmaceuticals; Risk Factors; Thiazoles; Tomography, X-Ray Computed | 2013 |
Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Baltimore; Benzothiazoles; Cognition Disorders; Female; Glucose Intolerance; Humans; Insulin Resistance; Longitudinal Studies; Male; Prospective Studies; Radionuclide Imaging; Thiazoles | 2013 |
Reference region automatic extraction in dynamic [(11)C]PIB.
Topics: Algorithms; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Case-Control Studies; Cerebellum; Cluster Analysis; Humans; Plaque, Amyloid; Positron-Emission Tomography; Prefrontal Cortex; Reference Values; Reproducibility of Results; Thiazoles; Tissue Distribution | 2013 |
Longitudinal amyloid imaging using 11C-PiB: methodologic considerations.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Biomarkers; Brain; Cognitive Dysfunction; Female; Humans; Longitudinal Studies; Male; Molecular Imaging; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; Tissue Distribution | 2013 |
Comparison of neuroimaging modalities for the prediction of conversion from mild cognitive impairment to Alzheimer's dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Apolipoproteins E; Brain; Cognitive Dysfunction; Cohort Studies; Disease Progression; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Forecasting; Genotype; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Positron-Emission Tomography; Radiopharmaceuticals; Sensitivity and Specificity; Temporal Lobe; Thiazoles | 2014 |
Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Apolipoprotein E4; Brain; Case-Control Studies; Female; Fluorodeoxyglucose F18; Glucose; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Neuropsychological Tests; Positron-Emission Tomography; Temporal Lobe; Thiazoles | 2014 |
Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls.
Topics: Age Factors; Aged; Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Aniline Compounds; Animals; Autoradiography; Benzothiazoles; Brain; Brain Mapping; Calcium-Binding Proteins; Carbon Isotopes; Disease Models, Animal; DNA-Binding Proteins; Dose-Response Relationship, Drug; Female; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Middle Aged; Mutation; Positron-Emission Tomography; Protein Structure, Secondary; tau Proteins; Tauopathies; Thiazoles | 2013 |
Five-year follow-up of 11C-PIB uptake in Alzheimer's disease and MCI.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Case-Control Studies; Cognitive Dysfunction; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2014 |
Hippocampal and cortical atrophy in amyloid-negative mild cognitive impairments: comparison with amyloid-positive mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Atrophy; Cerebral Cortex; Cognitive Dysfunction; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Risk; Thiazoles | 2014 |
[18F]Flutemetamol amyloid-beta PET imaging compared with [11C]PIB across the spectrum of Alzheimer's disease.
Topics: Adult; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Case-Control Studies; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2014 |
Amyloid-β load predicts medial temporal lobe dysfunction in Alzheimer dementia.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Memory; Positron-Emission Tomography; Temporal Lobe; Thiazoles | 2013 |
Associations between Alzheimer disease biomarkers, neurodegeneration, and cognition in cognitively normal older people.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Biomarkers; Cognition Disorders; Cohort Studies; Community-Based Participatory Research; Cross-Sectional Studies; Female; Fluorodeoxyglucose F18; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Nerve Fibers, Myelinated; Neurodegenerative Diseases; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Thiazoles | 2013 |
In vivo type 1 cannabinoid receptor availability in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Benzothiazoles; Brain; Cognition; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Receptor, Cannabinoid, CB1; Thiazoles | 2014 |
Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease.
Topics: Adult; Age of Onset; Alzheimer Disease; Aniline Compounds; Biomarkers; Brain; Carbon Radioisotopes; Cohort Studies; Female; Fluorodeoxyglucose F18; Genes, Dominant; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Models, Biological; Positron-Emission Tomography; Regression Analysis; Thiazoles; Time Factors | 2013 |
A method of semi-quantifying β-AP in brain PET-CT 11C-PiB images.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Computer Simulation; Diagnosis, Computer-Assisted; Humans; Image Processing, Computer-Assisted; Positron-Emission Tomography; Radiographic Image Interpretation, Computer-Assisted; Radiopharmaceuticals; Reference Standards; Reproducibility of Results; Thiazoles; Tomography, X-Ray Computed | 2014 |
Quantitative analysis of PiB-PET with FreeSurfer ROIs.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Case-Control Studies; Female; Humans; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Software; Thiazoles | 2013 |
Imaging of amyloid deposition in human brain using positron emission tomography and [18F]FACT: comparison with [11C]PIB.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Benzoxazoles; Brain; Case-Control Studies; Cognitive Dysfunction; Female; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tissue Distribution | 2014 |
In vitro binding of [³H]PIB to human amyloid deposits of different types.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Case-Control Studies; Humans; Immunoglobulin Light Chains; Middle Aged; Plaque, Amyloid; Prealbumin; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Serum Amyloid A Protein; Thiazoles; Tissue Extracts; Tritium | 2014 |
Amyloid burden correlates with cognitive decline in Alzheimer's disease presenting with aphasia.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Aphasia; Cerebral Cortex; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2014 |
Plasma amyloid-β levels are significantly associated with a transition toward Alzheimer's disease as measured by cognitive decline and change in neocortical amyloid burden.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Cognition Disorders; Cohort Studies; Disease Progression; Female; Humans; Male; Mental Status Schedule; Middle Aged; Neocortex; Neuroimaging; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2014 |
Practical utility of amyloid and FDG-PET in an academic dementia center.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Cognition Disorders; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Positron-Emission Tomography; Radiopharmaceuticals; Retrospective Studies; Severity of Illness Index; Thiazoles | 2014 |
Comparison of two methods for the estimation of stability of copper(II) bis-complexes with aromatic ligands relevant to Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Copper; Humans; Ligands; Organometallic Compounds; Plaque, Amyloid; Regression Analysis; Thiazoles | 2013 |
Analysis of early phase [11C]BF-227 PET, and its application for anatomical standardization of late-phase images for 3D-SSP analysis.
Topics: Aged; Alzheimer Disease; Benzoxazoles; Brain; Carbon Radioisotopes; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Humans; Imaging, Three-Dimensional; Male; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles | 2014 |
A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman.
Topics: Alzheimer Disease; Aniline Compounds; Benzothiazoles; Black or African American; Brain; Female; Green Fluorescent Proteins; HEK293 Cells; Humans; Isoleucine; Methionine; Middle Aged; Mutation; Positron-Emission Tomography; Presenilin-1; Thiazoles; Transfection | 2014 |
MR-less surface-based amyloid assessment based on 11C PiB PET.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Reproducibility of Results; Thiazoles | 2014 |
[Application of thioflavin T staining in detection of β-amyloid].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Cerebral Amyloid Angiopathy; Fluorescent Dyes; Humans; Mice; Peptide Fragments; Staining and Labeling; Thiazoles | 2013 |
Beta-amyloid associated differential effects of APOE ε4 on brain metabolism in cognitively normal elderly.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Cerebral Cortex; Cognition; Female; Fluorodeoxyglucose F18; Functional Neuroimaging; Genotype; Glucose; Humans; Male; Memory, Episodic; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2014 |
In vivo evaluation of a novel tau imaging tracer for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Case-Control Studies; Female; Frontotemporal Dementia; Humans; Male; Middle Aged; Positron-Emission Tomography; Protein Binding; Quinolines; Radiopharmaceuticals; tau Proteins; Thiazoles; Tissue Distribution | 2014 |
Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Choline O-Acetyltransferase; Cognitive Dysfunction; Female; Humans; In Vitro Techniques; Male; Mental Status Schedule; Nerve Growth Factor; Neuropil Threads; Parietal Lobe; Prodromal Symptoms; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Statistics, Nonparametric; Thiazoles; Tritium | 2015 |
Aβ and cognitive change: examining the preclinical and prodromal stages of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cognition Disorders; Disease Progression; Female; Follow-Up Studies; Humans; Learning; Linear Models; Male; Memory Disorders; Memory, Short-Term; Neuropsychological Tests; Positron-Emission Tomography; Prodromal Symptoms; Psychiatric Status Rating Scales; Thiazoles | 2014 |
LRP-1 polymorphism is associated with global and regional amyloid load in Alzheimer's Disease in humans in-vivo.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloidogenic Proteins; Aniline Compounds; Benzothiazoles; Brain; Female; Genetic Predisposition to Disease; Humans; Low Density Lipoprotein Receptor-Related Protein-1; Male; Middle Aged; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; Tissue Distribution | 2014 |
Small vessel disease, but neither amyloid load nor metabolic deficit, is dependent on age at onset in Alzheimer's disease.
Topics: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Apolipoproteins E; Benzothiazoles; Brain; Female; Fluorodeoxyglucose F18; Humans; Male; Metabolic Diseases; Middle Aged; Radionuclide Imaging; Thiazoles; Vascular Diseases | 2015 |
The effect of amyloid pathology and glucose metabolism on cortical volume loss over time in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Cerebral Cortex; Female; Fluorodeoxyglucose F18; Glucose; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2014 |
Incidence of cerebral microbleeds in preclinical Alzheimer disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Australia; Brain; Cerebral Small Vessel Diseases; Female; Humans; Incidence; Intracranial Hemorrhages; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2014 |
Non-invasive assessment of Alzheimer's disease neurofibrillary pathology using 18F-THK5105 PET.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain Mapping; Carbon Radioisotopes; Female; Humans; Male; Neurofibrillary Tangles; Plaque, Amyloid; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; Thiazoles | 2014 |
Matched signal detection on graphs: theory and application to brain network classification.
Topics: Algorithms; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Brain Mapping; Connectome; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Nerve Net; Neural Pathways; Pattern Recognition, Automated; Positron-Emission Tomography; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; Tissue Distribution | 2013 |
Concordance between cerebrospinal fluid biomarkers and [11C]PIB PET in a memory clinic cohort.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Cohort Studies; Female; Humans; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Peptide Fragments; Positron-Emission Tomography; Psychiatric Status Rating Scales; tau Proteins; Thiazoles | 2014 |
Within-patient correspondence of amyloid-β and intrinsic network connectivity in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Brain; Brain Mapping; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2014 |
Parallel ICA of FDG-PET and PiB-PET in three conditions with underlying Alzheimer's pathology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Biomarkers; Brain; Data Interpretation, Statistical; Female; Fluorodeoxyglucose F18; Glucose; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Principal Component Analysis; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles | 2014 |
In Alzheimer's disease, hypometabolism in low-amyloid brain regions may be a functional consequence of pathologies in connected brain regions.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Carbon Radioisotopes; Case-Control Studies; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2014 |
Alzheimer's disease-like pattern of (18)F-FDG uptake during a hyperglycemic state and negative (11)C-PiB binding in a patient with mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Humans; Hyperglycemia; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2014 |
Vascular risk and Aβ interact to reduce cortical thickness in AD vulnerable brain regions.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Chi-Square Distribution; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Positron-Emission Tomography; Risk Factors; Thiazoles; Vascular Diseases | 2014 |
An increased neutrophil-lymphocyte ratio in Alzheimer's disease is a function of age and is weakly correlated with neocortical amyloid accumulation.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Chi-Square Distribution; Cognition Disorders; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Lymphocytes; Male; Memory, Episodic; Neocortex; Neutrophils; Psychiatric Status Rating Scales; Radionuclide Imaging; Thiazoles | 2014 |
[Alzheimer dementia: why therapy comes too late].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Cognitive Dysfunction; Disease Progression; Humans; Positron-Emission Tomography; Thiazoles | 2014 |
Imaging discrepancies between magnetic resonance imaging and brain perfusion single-photon emission computed tomography in the diagnosis of Alzheimer's disease, and verification with amyloid positron emission tomography.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Ambulatory Care Facilities; Amyloid; Brain; Cognitive Dysfunction; Female; Geriatric Assessment; Humans; Magnetic Resonance Imaging; Male; Neuroimaging; Regional Blood Flow; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2014 |
A distinct subfraction of Aβ is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brain.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Binding Sites; Brain Chemistry; Down Syndrome; Female; Frontal Lobe; Humans; In Vitro Techniques; Lipid Metabolism; Male; Proteomics; Thiazoles | 2014 |
Disrupted Intrinsic Networks Link Amyloid-β Pathology and Impaired Cognition in Prodromal Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Attention; Brain Mapping; Cognition; Cognitive Dysfunction; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2015 |
Plasma Aβ but not tau is related to brain PiB retention in early Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Chi-Square Distribution; Cognitive Dysfunction; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Psychiatric Status Rating Scales; Radionuclide Imaging; Regression Analysis; tau Proteins; Thiazoles | 2014 |
Comparison of dual-biomarker PIB-PET and dual-tracer PET in AD diagnosis.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Biomarkers; Carbon Radioisotopes; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles | 2014 |
Spared piriform cortical single-unit odor processing and odor discrimination in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Benzothiazoles; Disease Models, Animal; Entorhinal Cortex; Female; Habituation, Psychophysiologic; Hippocampus; Male; Memory; Mice, Transgenic; Odorants; Olfactory Bulb; Olfactory Pathways; Piriform Cortex; Thiazoles | 2014 |
Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years: a cross-sectional study.
Topics: Age Distribution; Aged; Aged, 80 and over; Alzheimer Disease; Amyloidosis; Aniline Compounds; Apolipoproteins E; Cognition; Cohort Studies; Cross-Sectional Studies; DNA; Educational Status; Female; Humans; Male; Middle Aged; Neurodegenerative Diseases; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Verbal Learning | 2014 |
The Alzheimer disease protective mutation A2T modulates kinetic and thermodynamic properties of amyloid-β (Aβ) aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Brain; Cell Culture Techniques; Cell Line; Cricetinae; Disease Models, Animal; Humans; Kinetics; Mice; Mice, Inbred C57BL; Mutagenesis; Mutation; Neurons; Peptide Fragments; Solubility; Thermodynamics; Thiazoles | 2014 |
Comparison of MR-less PiB SUVR quantification methods.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Gray Matter; Humans; Magnetic Resonance Imaging; Neuroimaging; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2015 |
Cortical hypermetabolism in MCI subjects: a compensatory mechanism?
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Blood Glucose; Cerebral Cortex; Cognitive Dysfunction; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2015 |
Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain; Brain Mapping; Female; Fluorodeoxyglucose F18; Glucose; Humans; Lewy Body Disease; Male; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2015 |
Detection of Aβ-interacting proteins via a novel Aβ-adsorbents that use immobilized regular comb polymer.
Topics: Adsorption; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain Chemistry; Fluorescent Dyes; Immobilized Proteins; Mice; Nerve Tissue Proteins; Polymers; Sepharose; Thiazoles | 2014 |
APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Brain-Derived Neurotrophic Factor; Cognition Disorders; Female; Follow-Up Studies; Genetic Engineering; Genotype; Humans; Male; Middle Aged; Neuropsychological Tests; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Psychiatric Status Rating Scales; Thiazoles | 2015 |
Physical activity attenuates age-related biomarker alterations in preclinical AD.
Topics: Adult; Age Factors; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Brain; Female; Fluorodeoxyglucose F18; Humans; Longitudinal Studies; Male; Middle Aged; Motor Activity; Neuroimaging; Neuropsychological Tests; Radionuclide Imaging; Risk Factors; Surveys and Questionnaires; Thiazoles; Visual Perception | 2014 |
Pitfalls of voxel-based amyloid PET analyses for diagnosis of Alzheimer's disease: artifacts due to non-specific uptake in the white matter and the skull.
Topics: Aged; Alzheimer Disease; Amyloid; Artifacts; Benzoxazoles; Cognitive Dysfunction; Dementia; Demography; Female; Humans; Male; Positron-Emission Tomography; Skull; Thiazoles; White Matter | 2014 |
Thioflavin-based molecular probes for application in Alzheimer's disease: from in silico to in vitro models.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Brain; Brain Chemistry; Cell Line; Cell Survival; Humans; Mice; Models, Biological; Molecular Docking Simulation; Molecular Probes; Phenols; Thiazoles | 2015 |
Exploiting the therapeutic potential of 8-β-d-glucopyranosylgenistein: synthesis, antidiabetic activity, and molecular interaction with islet amyloid polypeptide and amyloid β-peptide (1-42).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Diabetes Mellitus, Experimental; Drug Design; Epitopes; Genista; Genistein; Glucosides; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Islet Amyloid Polypeptide; Magnetic Resonance Spectroscopy; Microscopy, Atomic Force; Microscopy, Fluorescence; Oxygen; Protein Binding; Protein Conformation; Protein Kinase Inhibitors; Rats; Rats, Wistar; Streptozocin; Thiazoles | 2014 |
Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Crown Ethers; Hippocampus; Ligands; Mice; Microscopy, Confocal; Peptide Fragments; Thiazoles | 2014 |
Investigation of (11)C-PiB equivocal PET findings.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Female; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Positron-Emission Tomography; Retrospective Studies; Thiazoles | 2015 |
Effects of amyloid and small vessel disease on white matter network disruption.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Cognition Disorders; Dementia, Vascular; Diffusion Tensor Imaging; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Networks, Computer; Neural Pathways; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles; White Matter | 2015 |
Effects of Beta-Amyloid on Resting State Functional Connectivity Within and Between Networks Reflect Known Patterns of Regional Vulnerability.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Brain Mapping; Carbon Isotopes; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Nerve Net; Oxygen; Positron-Emission Tomography; Regression Analysis; Rest; Thiazoles; Young Adult | 2016 |
The Centiloid Project: standardizing quantitative amyloid plaque estimation by PET.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Calibration; Fluorodeoxyglucose F18; Humans; Image Interpretation, Computer-Assisted; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2015 |
Hippocampal volume and shape in pure subcortical vascular dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Atrophy; Carbon Radioisotopes; Cognition; Dementia, Vascular; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2015 |
Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain.
Topics: Aged; Alzheimer Disease; Amyloid; Benzothiazoles; Blotting, Western; Brain; Cell Line, Tumor; Female; Fluorescent Antibody Technique; Histones; Humans; Male; Neurofibrillary Tangles; Plaque, Amyloid; tau Proteins; Thiazoles; Tissue Array Analysis; Ubiquitin | 2015 |
Partial volume correction in quantitative amyloid imaging.
Topics: Algorithms; Alzheimer Disease; Amyloid; Amyloid Neuropathies; Aniline Compounds; Benzothiazoles; Cerebral Cortex; Cohort Studies; Computer Simulation; Cross-Sectional Studies; Humans; Individuality; Longitudinal Studies; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles | 2015 |
Periodontal disease associates with higher brain amyloid load in normal elderly.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Carbon Radioisotopes; Female; Humans; Male; Middle Aged; Periodontal Diseases; Phenanthrolines; Positron-Emission Tomography; Radiopharmaceuticals; Regression Analysis; Thiazoles | 2015 |
Degree of abnormality is associated with rate of change in measures of beta-amyloid, glucose metabolism and cognition in an autopsy-verified Alzheimer's disease case.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Cognition; Disease Progression; Fatal Outcome; Female; Fluorodeoxyglucose F18; Glucose; Humans; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2015 |
Pretreatment of chemically-synthesized Aβ42 affects its biological activity in yeast.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apoptosis; Benzothiazoles; Candida glabrata; Flow Cytometry; Microscopy, Confocal; Microscopy, Electron, Transmission; Neurons; Peptide Fragments; Peptides; Propanols; Protein Binding; Protein Conformation; Saccharomyces cerevisiae; Thiazoles | 2014 |
Towards ratiometric sensing of amyloid fibrils in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Cattle; Electrochemistry; Fluorescence; Fluorescent Dyes; Humans; Imidazoles; Protein Binding; Pyridines; Serum Albumin, Bovine; Thiazoles | 2015 |
Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Animals, Newborn; Anti-Inflammatory Agents; Calcium-Binding Proteins; Cell Adhesion Molecules; Cells, Cultured; Complement C1q; Complement C3; Disease Models, Animal; Embryo, Mammalian; Female; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Humans; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Phosphopyruvate Hydratase; PPAR delta; Thiazoles | 2015 |
Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Cerebrovascular Disorders; Cognition Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles; Tomography Scanners, X-Ray Computed | 2015 |
White matter microstructural changes in pure Alzheimer's disease and subcortical vascular dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Dementia, Vascular; Diffusion Tensor Imaging; Female; Humans; Male; Middle Aged; Thiazoles; White Matter | 2015 |
Brain amyloidosis ascertainment from cognitive, imaging, and peripheral blood protein measures.
Topics: Aged; Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Aniline Compounds; Biomarkers; Brain; Cognition; Cognitive Dysfunction; Cohort Studies; Databases, Factual; Disease Progression; Female; Humans; Male; Neuropsychological Tests; Pattern Recognition, Automated; Peptide Fragments; Positron-Emission Tomography; Sensitivity and Specificity; Thiazoles | 2015 |
Rationally designed peptidomimetic modulators of aβ toxicity in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Autophagy; Benzothiazoles; Biological Assay; Circular Dichroism; Drug Design; Green Fluorescent Proteins; Humans; Kinetics; Microscopy, Fluorescence; Models, Biological; Peptide Fragments; Peptidomimetics; Protein Aggregates; Proteolysis; Saccharomyces cerevisiae; Thiazoles | 2015 |
Concordance and Diagnostic Accuracy of [11C]PIB PET and Cerebrospinal Fluid Biomarkers in a Sample of Patients with Mild Cognitive Impairment and Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Biomarkers; Brain; Cognitive Dysfunction; Cohort Studies; Diagnosis, Differential; Female; Follow-Up Studies; Humans; Logistic Models; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Phosphorylation; Positron-Emission Tomography; Radiopharmaceuticals; tau Proteins; Thiazoles | 2015 |
Microbleeds in atypical presentations of Alzheimer's disease: a comparison to dementia of the Alzheimer's type.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Cerebral Hemorrhage; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Phenotype; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2015 |
Decreased platelet APP isoform ratios in autosomal dominant Alzheimer's disease: baseline data from a DIAN cohort subset.
Topics: Adult; Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Apolipoprotein E4; Blotting, Western; Caudate Nucleus; Female; Heterozygote; Humans; Isomerism; Longitudinal Studies; Male; Mental Status Schedule; Middle Aged; Mutation; Neuropsychological Tests; Parietal Lobe; Positron-Emission Tomography; Thiazoles; Western Australia | 2015 |
Depressive Symptoms and Biomarkers of Alzheimer's Disease in Cognitively Normal Older Adults.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Biomarkers; Depression; Female; Fluorodeoxyglucose F18; Geriatric Assessment; Hippocampus; Humans; Linear Models; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Principal Component Analysis; Psychiatric Status Rating Scales; Residence Characteristics; Thiazoles | 2015 |
Stabilization of nontoxic Aβ-oligomers: insights into the mechanism of action of hydroxyquinolines in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Biophysics; Caenorhabditis elegans; Cells, Cultured; Cerebral Cortex; Chromatography, Gel; Clioquinol; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxyquinolines; Mice; Microscopy, Electron; Neurons; Peptide Fragments; Protein Binding; Scattering, Small Angle; Thiazoles | 2015 |
Preclinical Comparison of the Amyloid-β Radioligands [(11)C]Pittsburgh compound B and [(18)F]florbetaben in Aged APPPS1-21 and BRI1-42 Mouse Models of Cerebral Amyloidosis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Disease Models, Animal; Immunohistochemistry; Mice; Positron-Emission Tomography; Radiopharmaceuticals; Stilbenes; Thiazoles | 2015 |
Interaction of PiB-derivative metal complexes with beta-amyloid peptides: selective recognition of the aggregated forms.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Coordination Complexes; Heterocyclic Compounds, 1-Ring; Humans; Lanthanoid Series Elements; Magnetic Resonance Spectroscopy; Peptide Fragments; Protein Aggregates; Surface Plasmon Resonance; Thiazoles | 2015 |
Exploring structural requirements of imaging agents against Aβ plaques in Alzheimer's disease: a QSAR approach.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Molecular Structure; Quantitative Structure-Activity Relationship; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2015 |
A test of lens opacity as an indicator of preclinical Alzheimer Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Asymptomatic Diseases; Biomarkers; Carbon Radioisotopes; Cataract; Densitometry; Female; Humans; Lens, Crystalline; Light; Male; Peptide Fragments; Plaque, Amyloid; Positron-Emission Tomography; Risk Assessment; Scattering, Radiation; Thiazoles | 2015 |
[(18)F]THK-5117 PET for assessing neurofibrillary pathology in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Case-Control Studies; Cerebral Cortex; Female; Humans; Male; Neurofibrils; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; Thiazoles | 2015 |
Clinicopathologic and 11C-Pittsburgh compound B implications of Thal amyloid phase across the Alzheimer's disease spectrum.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Female; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2015 |
Concordance between 11C-PIB-PET and clinical diagnosis in a memory clinic.
Topics: Aged; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Aniline Compounds; Aphasia, Primary Progressive; Atrophy; Benzothiazoles; Cerebral Amyloid Angiopathy; Cerebral Cortex; Cognitive Dysfunction; Dementia; Female; Frontotemporal Lobar Degeneration; Humans; Male; Middle Aged; Positron-Emission Tomography; Retrospective Studies; Thiazoles | 2015 |
Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Australia; Blood Proteins; Cohort Studies; Female; Humans; Male; Middle Aged; Neocortex; Positron-Emission Tomography; Proteins; Proteomics; Thiazoles | 2015 |
Connectivity analysis of normal and mild cognitive impairment patients based on FDG and PiB-PET images.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain; Case-Control Studies; Cognitive Dysfunction; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Male; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2015 |
Clustering-initiated factor analysis application for tissue classification in dynamic brain positron emission tomography.
Topics: Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Carbon Radioisotopes; Cluster Analysis; Factor Analysis, Statistical; Humans; Neuroimaging; Positron-Emission Tomography; Reproducibility of Results; Thiazoles | 2015 |
Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Axl Receptor Tyrosine Kinase; Benzoates; Benzylamines; Bexarotene; c-Mer Tyrosine Kinase; Cells, Cultured; Disease Models, Animal; Gene Expression Regulation; Leukocyte Common Antigens; Macrophages; Male; Membrane Glycoproteins; Mice; Microglia; Myeloid Cells; Phagocytosis; Pioglitazone; Plaque, Amyloid; Proto-Oncogene Proteins; Receptor Protein-Tyrosine Kinases; Receptors, Cytoplasmic and Nuclear; Receptors, Immunologic; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones | 2015 |
Protective effect of sulfurous water in peripheral blood mononuclear cells of Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Cell Survival; Comet Assay; DNA Damage; Drug Evaluation, Preclinical; Female; Humans; Hydrogen Sulfide; In Vitro Techniques; Leukocytes, Mononuclear; Male; Tetrazolium Salts; Thiazoles; Water | 2015 |
Modeling clustered activity increase in amyloid-beta positron emission tomographic images with statistical descriptors.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Cerebrospinal Fluid; Female; Humans; Image Processing, Computer-Assisted; Male; Models, Statistical; Positron-Emission Tomography; Thiazoles | 2015 |
Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Female; Humans; Image Interpretation, Computer-Assisted; Male; Positron-Emission Tomography; Radiopharmaceuticals; Reference Values; Thiazoles; Young Adult | 2015 |
Changes in Aβ biomarkers and associations with APOE genotype in 2 longitudinal cohorts.
Topics: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Brain; Carbon Radioisotopes; Cohort Studies; Female; Genotype; Heterozygote; Humans; Longitudinal Studies; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2015 |
A spectral graph regression model for learning brain connectivity of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Female; Fourier Analysis; Humans; Male; Models, Biological; Positron-Emission Tomography; Reference Values; Regression Analysis; Thiazoles | 2015 |
Amyloid Beta-Weighted Cortical Thickness: A New Imaging Biomarker in Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain Mapping; Cerebral Cortex; Cognitive Dysfunction; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Neurofibrillary Tangles; Positron-Emission Tomography; Thiazoles | 2015 |
Relative 11C-PiB Delivery as a Proxy of Relative CBF: Quantitative Evaluation Using Single-Session 15O-Water and 11C-PiB PET.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Blood-Brain Barrier; Brain; Carbon Isotopes; Cerebrovascular Circulation; Cohort Studies; Drug Delivery Systems; Female; Humans; Image Processing, Computer-Assisted; Kinetics; Male; Middle Aged; Neuroimaging; Oxygen Isotopes; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles; Water | 2015 |
Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Cerebral Cortex; Cohort Studies; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Radiography; Self Report; Sleep Wake Disorders; Statistics as Topic; Thiazoles | 2015 |
Clinical impact of (11)C-Pittsburgh compound-B positron emission tomography carried out in addition to magnetic resonance imaging and single-photon emission computed tomography on the diagnosis of Alzheimer's disease in patients with dementia and mild cog
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Cognitive Dysfunction; Dementia; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Thiazoles; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2015 |
A Comparison of Three Fluorophores for the Detection of Amyloid Fibers and Prefibrillar Oligomeric Assemblies. ThT (Thioflavin T); ANS (1-Anilinonaphthalene-8-sulfonic Acid); and bisANS (4,4'-Dianilino-1,1'-binaphthyl-5,5'-disulfonic Acid).
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Anilino Naphthalenesulfonates; Benzothiazoles; Diabetes Mellitus, Type 2; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Molecular Sequence Data; Spectrometry, Fluorescence; Thiazoles | 2015 |
Combination of dynamic (11)C-PIB PET and structural MRI improves diagnosis of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Atrophy; Cognitive Dysfunction; Female; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Positron-Emission Tomography; Thiazoles | 2015 |
Amyloid deposits and response to shunt surgery in idiopathic normal-pressure hydrocephalus.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Analysis of Variance; Benzoxazoles; Cerebrospinal Fluid Shunts; Female; Humans; Hydrocephalus, Normal Pressure; Image Processing, Computer-Assisted; Japan; Magnetic Resonance Imaging; Male; Middle Aged; Neocortex; Positron-Emission Tomography; Retrospective Studies; Statistics as Topic; Thiazoles | 2015 |
Thioflavin T templates amyloid β(1-40) conformation and aggregation pathway.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Fluorescence Recovery After Photobleaching; Fluorescent Dyes; Humans; Molecular Dynamics Simulation; Molecular Sequence Data; Peptide Fragments; Protein Aggregates; Protein Aggregation, Pathological; Protein Conformation; Protein Multimerization; Protein Stability; Protein Structure, Secondary; Thiazoles | 2015 |
The effects of white matter hyperintensities and amyloid deposition on Alzheimer dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Severity of Illness Index; Thiazoles; White Matter | 2015 |
Amyloid PET in European and North American cohorts; and exploring age as a limit to clinical use of amyloid imaging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Cognitive Dysfunction; Cohort Studies; Ethylene Glycols; Europe; Female; Humans; Male; Middle Aged; Molecular Imaging; North America; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Sex Characteristics; Thiazoles | 2015 |
Chiral Metallo-Supramolecular Complex Directed Enantioselective Self-Assembly of β-Sheet Breaker Peptide for Amyloid Inhibition.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Humans; Kinetics; Metal Nanoparticles; Metals; Nanotechnology; PC12 Cells; Protein Structure, Secondary; Rats; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Temperature; Thiazoles | 2015 |
Longitudinal assessment of neuroimaging and clinical markers in autosomal dominant Alzheimer's disease: a prospective cohort study.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Aniline Compounds; Biomarkers; Cerebral Cortex; Disease Progression; Female; Hippocampus; Humans; Male; Middle Aged; Prospective Studies; Thiazoles | 2015 |
Longitudinal Cerebrospinal Fluid Biomarker Changes in Preclinical Alzheimer Disease During Middle Age.
Topics: Adipokines; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Asymptomatic Diseases; Biomarkers; Chitinase-3-Like Protein 1; Cohort Studies; Female; Genotyping Techniques; Humans; Lectins; Male; Middle Aged; Neurocalcin; Peptide Fragments; Positron-Emission Tomography; tau Proteins; Thiazoles | 2015 |
William Klunk: imaging Alzheimer's disease in vivo.
Topics: Alzheimer Disease; Aniline Compounds; History, 20th Century; History, 21st Century; Humans; Positron-Emission Tomography; Thiazoles | 2015 |
Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Carbon-13 Magnetic Resonance Spectroscopy; Disease Models, Animal; Drug Monitoring; Fluorescent Dyes; Humans; Mice, Transgenic; Molecular Imaging; Photons; Presenilin-1; Proton Magnetic Resonance Spectroscopy; Spectrometry, Fluorescence; Spectroscopy, Near-Infrared; Thiazoles; Tissue Extracts; Titrimetry | 2015 |
Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy.
Topics: Acrylamides; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Kinetics; Molecular Structure; Naphthalenes; Peptide Fragments; Protein Aggregates; Solubility; Spectrometry, Fluorescence; Thiazoles | 2015 |
Amyloid-Independent Amnestic Mild Cognitive Impairment and Serum Apolipoprotein A1 Levels.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amnesia; Amyloid; Aniline Compounds; Apolipoprotein A-I; Atrophy; Brain; Brain Mapping; Cognitive Dysfunction; Cross-Sectional Studies; Disease Progression; Female; Follow-Up Studies; Humans; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2016 |
Potential of aryl-urea-benzofuranylthiazoles hybrids as multitasking agents in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzofurans; Butyrylcholinesterase; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Dynamics Simulation; Molecular Structure; Structure-Activity Relationship; Thiazoles; Torpedo; Urea | 2015 |
Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Humans; Positron-Emission Tomography; Quality Control; Radiopharmaceuticals; Thiazoles | 2015 |
Investigation of the Binding Profiles of AZD2184 and Thioflavin T with Amyloid-β(1-42) Fibril by Molecular Docking and Molecular Dynamics Methods.
Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Benzothiazoles; Drug Design; Elasticity; Fluorescent Dyes; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Peptide Fragments; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Static Electricity; Thiazoles | 2015 |
Early-onset Alzheimer's disease versus frontotemporal dementia: resolution with genetic diagnoses?
Topics: Alzheimer Disease; Aniline Compounds; Apolipoproteins E; Brain; C9orf72 Protein; Carbon Isotopes; Emotions; Fluorodeoxyglucose F18; Frontotemporal Dementia; Humans; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Mutation; Neuropsychological Tests; Positron-Emission Tomography; Proteins; Social Behavior; Thiazoles; Verbal Learning | 2016 |
Anthocyanin suppresses the toxicity of Aβ deposits through diversion of molecular forms in in vitro and in vivo models of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Anthocyanins; Benzothiazoles; Brain; Cell Line, Tumor; Cognition; Cognition Disorders; Female; Humans; Male; Mice; Microscopy, Atomic Force; Peptide Fragments; Plant Extracts; Polyphenols; Thiazoles; Vaccinium myrtillus | 2016 |
Distinct binding of amyloid imaging ligands to unique amyloid-β deposited in the presubiculum of Alzheimer's disease.
Topics: Alzheimer Disease; Aminopyridines; Amyloidogenic Proteins; Aniline Compounds; Autoradiography; Benzothiazoles; Humans; Imidazoles; In Vitro Techniques; Parahippocampal Gyrus; Plaque, Amyloid; Positron-Emission Tomography; Pyridines; Radiopharmaceuticals; Receptors, GABA; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2015 |
Synthesis, molecular docking, acetylcholinesterase and butyrylcholinesterase inhibitory potential of thiazole analogs as new inhibitors for Alzheimer disease.
Topics: Alzheimer Disease; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Molecular Docking Simulation; Thiazoles | 2015 |
[PET with amyloid ligands should not be applied routinely in early diagnostics of Alzheimer's disease].
Topics: Alzheimer Disease; Aniline Compounds; Benzothiazoles; Early Diagnosis; Humans; Positron-Emission Tomography; Review Literature as Topic; Sensitivity and Specificity; Thiazoles | 2015 |
A novel antagonistic role of natural compound icariin on neurotoxicity of amyloid β peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Cell Line; Cell Survival; Flavonoids; Humans; Hydrogen Peroxide; Microscopy, Electron, Transmission; Neurons; Peptide Fragments; Protein Aggregation, Pathological; Thiazoles | 2015 |
Influence of Amyloid-β on Cognitive Decline After Stroke/Transient Ischemic Attack: Three-Year Longitudinal Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Carbon Radioisotopes; Cognition Disorders; Female; Follow-Up Studies; Humans; Ischemic Attack, Transient; Longitudinal Studies; Male; Positron-Emission Tomography; Registries; Stroke; Thiazoles; Time Factors | 2015 |
Alzheimer's Disease Normative Cerebrospinal Fluid Biomarkers Validated in PET Amyloid-β Characterized Subjects from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Australia; Benzothiazoles; Ethylene Glycols; Female; Humans; Life Style; Longitudinal Studies; Male; Mental Status Schedule; Peptide Fragments; Positron-Emission Tomography; ROC Curve; tau Proteins; Thiazoles | 2015 |
Novel Statistically-Derived Composite Measures for Assessing the Efficacy of Disease-Modifying Therapies in Prodromal Alzheimer's Disease Trials: An AIBL Study.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Apolipoproteins E; Australia; Biomarkers; Disease Progression; Female; Humans; Life Style; Longitudinal Studies; Male; Mental Status Schedule; Neuroimaging; Neuropsychological Tests; Prodromal Symptoms; Reproducibility of Results; Thiazoles | 2015 |
Alzheimer Disease Cerebrospinal Fluid Biomarkers Moderate Baseline Differences and Predict Longitudinal Change in Attentional Control and Episodic Memory Composites in the Adult Children Study.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Attention Deficit Disorder with Hyperactivity; Biomarkers; Enzyme-Linked Immunosorbent Assay; Female; Humans; Longitudinal Studies; Male; Memory Disorders; Memory, Episodic; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Predictive Value of Tests; Psychiatric Status Rating Scales; Thiazoles | 2015 |
Role of β-Amyloidosis and Neurodegeneration in Subsequent Imaging Changes in Mild Cognitive Impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloidosis; Aniline Compounds; Cognitive Dysfunction; Cohort Studies; Disease Progression; Female; Fluorodeoxyglucose F18; Gray Matter; Humans; Male; Neurodegenerative Diseases; Positron-Emission Tomography; Thiazoles | 2015 |
Molecular "light switch" [Ru(phen)2dppzidzo](2+) monitoring the aggregation of tau.
Topics: Alzheimer Disease; Benzothiazoles; Fluorescent Dyes; Humans; Light; Luminescent Agents; Luminescent Measurements; Models, Molecular; Organometallic Compounds; Protein Aggregates; Protein Aggregation, Pathological; tau Proteins; Thiazoles | 2015 |
Characterizing White Matter Tract Degeneration in Syndromic Variants of Alzheimer's Disease: A Diffusion Tensor Imaging Study.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Anisotropy; Aphasia, Primary Progressive; Case-Control Studies; Diffusion Tensor Imaging; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Nerve Fibers, Myelinated; Neurodegenerative Diseases; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Retrospective Studies; Thiazoles; White Matter | 2016 |
Tau positron emission tomographic imaging in aging and early Alzheimer disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Carbolines; Cerebral Cortex; Cognitive Dysfunction; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; tau Proteins; Temporal Lobe; Thiazoles | 2016 |
Longitudinal influence of microglial activation and amyloid on neuronal function in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Case-Control Studies; Disease Progression; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Functional Neuroimaging; Glucose; Humans; Isoquinolines; Male; Microglia; Middle Aged; Neurons; Positron-Emission Tomography; Thiazoles | 2015 |
Oral Administration of Thioflavin T Prevents Beta Amyloid Plaque Formation in Double Transgenic AD Mice.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Benzothiazoles; Brain; Disease Models, Animal; Female; Male; Mice, Transgenic; Microglia; Neuroprotective Agents; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2015 |
Bivalent ligands incorporating curcumin and diosgenin as multifunctional compounds against Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Curcumin; Diosgenin; Drug Design; Humans; Ligands; Neuroprotective Agents; Reactive Oxygen Species; Thiazoles | 2015 |
Cardiorespiratory Fitness Attenuates the Influence of Amyloid on Cognition.
Topics: Adult; Aged; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Exercise Test; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Oxygen Consumption; Peptide Fragments; Physical Fitness; Positron-Emission Tomography; Psychiatric Status Rating Scales; Thiazoles; Verbal Learning | 2015 |
Visual Versus Fully Automated Analyses of 18F-FDG and Amyloid PET for Prediction of Dementia Due to Alzheimer Disease in Mild Cognitive Impairment.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Cognitive Dysfunction; Dementia; Disease Progression; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Observer Variation; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; Thiazoles | 2016 |
Biomarker validation of a decline in semantic processing in preclinical Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Disease Progression; Female; Follow-Up Studies; Humans; Male; Mental Recall; Positron-Emission Tomography; Prodromal Symptoms; Semantics; Thiazoles | 2016 |
Comparison of qualitative and quantitative imaging characteristics of [11C]PiB and [18F]flutemetamol in normal control and Alzheimer's subjects.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2015 |
Difficulties associated with the structural analysis of proteins susceptible to form aggregates: The case of Tau protein as a biomarker of Alzheimer's disease.
Topics: Adhesiveness; Adsorption; Alzheimer Disease; Amino Acid Motifs; Antibodies, Monoclonal; Benzothiazoles; Biomarkers; Chymotrypsin; Epitopes; Humans; Magnetics; Mass Spectrometry; Proteolysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; tau Proteins; Thiazoles; Trypsin | 2016 |
PET Radioligands Reveal the Basis of Dementia in Parkinson's Disease and Dementia with Lewy Bodies.
Topics: Alzheimer Disease; Aniline Compounds; Brain; Carbolines; Cocaine; Cognitive Dysfunction; Cross-Sectional Studies; Diagnosis, Differential; Lewy Body Disease; Magnetic Resonance Imaging; Neuropsychological Tests; Parkinson Disease; Prospective Studies; Radionuclide Imaging; Radiopharmaceuticals; Survival Analysis; Thiazoles | 2016 |
In vivo molecular neuroimaging of glucose utilization and its association with fibrillar amyloid-β load in aged APPPS1-21 mice.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Autoradiography; Brain; Brain Mapping; Carbon Radioisotopes; Ethylene Glycols; Female; Fluorodeoxyglucose F18; Glucose; Humans; Immunohistochemistry; Mice, Inbred C57BL; Mice, Transgenic; Phenanthrolines; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2015 |
Differential Effects of Structural Modifications on the Competition of Chalcones for the PIB Amyloid Imaging Ligand-Binding Site in Alzheimer's Disease Brain and Synthetic Aβ Fibrils.
Topics: Aged; Alkenes; Alzheimer Disease; Amyloid beta-Peptides; Amyloidogenic Proteins; Aniline Compounds; Benzoates; Benzothiazoles; Binding Sites; Brain; Chalcones; Female; Fluorescent Dyes; Humans; Ligands; Peptide Fragments; Positron-Emission Tomography; Thiazoles; Tritium | 2016 |
Distinctive Resting State Network Disruptions Among Alzheimer's Disease, Subcortical Vascular Dementia, and Mixed Dementia Patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Cerebral Cortex; Cross-Sectional Studies; Dementia; Dementia, Vascular; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Models, Neurological; Neural Pathways; Neuropsychological Tests; Oxygen; Psychiatric Status Rating Scales; Radionuclide Imaging; Rest; Thiazoles | 2016 |
High amyloid-β deposition related to depressive symptoms in older individuals with normal cognition: a pilot study.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Cognition; Depression; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Pilot Projects; Positron-Emission Tomography; Thiazoles | 2016 |
Aβ-mediated spine changes in the hippocampus are microtubule-dependent and can be reversed by a subnanomolar concentration of the microtubule-stabilizing agent epothilone D.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cells, Cultured; Dendritic Spines; Diamines; Epothilones; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nocodazole; PC12 Cells; Rats; Thiazoles; Tubulin Modulators | 2016 |
Design and discovery of Novel Thiazole acetamide derivatives as anticholinesterase agent for possible role in the management of Alzheimer's.
Topics: Acetamides; Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Binding Sites; Butyrylcholinesterase; Cell Survival; Cholinesterase Inhibitors; Drug Design; Drug Evaluation, Preclinical; HeLa Cells; Humans; Inhibitory Concentration 50; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship; Thiazoles | 2016 |
Evaluation of [11C]TAZA for amyloid β plaque imaging in postmortem human Alzheimer's disease brain region and whole body distribution in rodent PET/CT.
Topics: Alzheimer Disease; Aniline Compounds; Animals; Benzothiazoles; Hippocampus; Humans; Male; Multimodal Imaging; p-Dimethylaminoazobenzene; Plaque, Amyloid; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Species Specificity; Thiazoles; Tissue Distribution; Tomography, X-Ray Computed; Whole Body Imaging | 2016 |
Amyloid deposition in semantic dementia: a positron emission tomography study.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Case-Control Studies; Cerebral Cortex; Female; Frontotemporal Dementia; Humans; Male; Middle Aged; Neurodegenerative Diseases; Positron-Emission Tomography; Thiazoles | 2016 |
Local and distributed PiB accumulation associated with development of preclinical Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Female; Follow-Up Studies; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Multivariate Analysis; Neuroimaging; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles; Tissue Distribution | 2016 |
Non-Verbal Episodic Memory Deficits in Primary Progressive Aphasias are Highly Predictive of Underlying Amyloid Pathology.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Aphasia, Primary Progressive; Brain; Diagnosis, Differential; Female; Humans; Logistic Models; Male; Memory, Episodic; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Speech Perception; Thiazoles | 2016 |
Longitudinal Memory Profiles in Behavioral-Variant Frontotemporal Dementia and Alzheimer's Disease.
Topics: Alzheimer Disease; Aniline Compounds; Brain; Diagnosis, Differential; Disease Progression; Executive Function; Female; Follow-Up Studies; Frontotemporal Dementia; Humans; Longitudinal Studies; Male; Memory; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2016 |
Comparison of Early-Phase 11C-Deuterium-l-Deprenyl and 11C-Pittsburgh Compound B PET for Assessing Brain Perfusion in Alzheimer Disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Cerebellum; Cerebrovascular Circulation; Cognitive Dysfunction; Deuterium; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Gliosis; Gray Matter; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Perfusion; Pons; Positron-Emission Tomography; Radiopharmaceuticals; Selegiline; Thiazoles | 2016 |
Meloxicam-loaded nanocapsules as an alternative to improve memory decline in an Alzheimer's disease model in mice: involvement of Na(+), K(+)-ATPase.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Cerebral Cortex; Cyclooxygenase 2; Disease Models, Animal; Hippocampus; Meloxicam; Memory; Memory Disorders; Mice; Nanocapsules; Sodium-Potassium-Exchanging ATPase; Thiazines; Thiazoles | 2016 |
PET Imaging of Tau Deposition in the Aging Human Brain.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Apolipoproteins E; Brain; Cognition Disorders; Ethylene Glycols; Female; Humans; Male; Positron-Emission Tomography; Psychiatric Status Rating Scales; tau Proteins; Thiazoles; Young Adult | 2016 |
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid; Aniline Compounds; Apolipoproteins E; Benzothiazoles; Brain; Carbolines; Case-Control Studies; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Neuroimaging; Neuropsychological Tests; Positron-Emission Tomography; tau Proteins; Thiazoles | 2016 |
Left Anterior Temporal Glucose Metabolism and not Amyloid-beta Load Predicts Naming Impairment in Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Female; Fluorodeoxyglucose F18; Glucose; Humans; Linear Models; Male; Mental Status Schedule; Neuropsychological Tests; Pattern Recognition, Visual; Positron-Emission Tomography; Radiopharmaceuticals; Temporal Lobe; Terminology as Topic; Thiazoles | 2016 |
N-Adamantyl-4-methylthiazol-2-amine suppresses amyloid β-induced neuronal oxidative damage in cortical neurons.
Topics: Adamantane; Alzheimer Disease; Amyloid beta-Peptides; Animals; Neurons; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thiazoles | 2016 |
Diagnostic and Prognostic Utility of the Synaptic Marker Neurogranin in Alzheimer Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Atrophy; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Disease Progression; Female; Humans; Independent Living; Male; Middle Aged; Neurocalcin; Neurogranin; Neuropsychological Tests; Peptide Fragments; Positron-Emission Tomography; Predictive Value of Tests; ROC Curve; Severity of Illness Index; Statistics, Nonparametric; tau Proteins; Thiazoles | 2016 |
Early [(18)F]florbetaben and [(11)C]PiB PET images are a surrogate biomarker of neuronal injury in Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Biological Transport; Female; Hippocampus; Humans; Male; Middle Aged; Neurons; Positron-Emission Tomography; Stilbenes; Thiazoles; Time Factors | 2016 |
Blood-Based Biomarker Candidates of Cerebral Amyloid Using PiB PET in Non-Demented Elderly.
Topics: Aged; alpha-Macroglobulins; Alzheimer Disease; Amyloidogenic Proteins; Aniline Compounds; Benzothiazoles; Biomarkers; Brain; Brain Chemistry; Female; Humans; Male; Positron-Emission Tomography; Tandem Mass Spectrometry; Thiazoles | 2016 |
A High Affinity Red Fluorescence and Colorimetric Probe for Amyloid β Aggregates.
Topics: Absorption, Radiation; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Colorimetry; Fluorescent Dyes; Fluorometry; Humans; Molecular Docking Simulation; Molecular Structure; Peptide Fragments; Protein Aggregation, Pathological; Thiazoles | 2016 |
Pittsburgh compound B and other amyloid positron emission tomography tracers for the study of white matter and multiple sclerosis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Humans; Multiple Sclerosis; Positron-Emission Tomography; Thiazoles; White Matter | 2016 |
Comparability of [
Topics: Alzheimer Disease; Aniline Compounds; Brain; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Positron-Emission Tomography; Quinolines; Radiopharmaceuticals; Thiazoles | 2017 |
Synthesis of Thiazolo[5,4-f]quinazolin-9(8H)-ones as Multi-Target Directed Ligands of Ser/Thr Kinases.
Topics: Alzheimer Disease; Animals; Humans; Ligands; Molecular Structure; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Quinazolinones; Swine; Thiazoles | 2016 |
Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Animals; Antioxidants; Benzothiazoles; Conditioning, Psychological; Fear; Female; Humans; Iofetamine; Magnetic Resonance Imaging; Male; Memory Disorders; Mental Recall; Mental Status and Dementia Tests; Mice; Mice, Inbred C57BL; Neuropsychological Tests; Positron-Emission Tomography; Quercetin; Thiazoles | 2016 |
Analysis of Cerebrospinal Fluid and [11C]PIB PET Biomarkers for Alzheimer's Disease with Updated Protocols.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Carbon Radioisotopes; Case-Control Studies; Clinical Protocols; Female; Humans; Immunoassay; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Sensitivity and Specificity; tau Proteins; Thiazoles | 2016 |
Candidate PET Radioligand Development for Neurofibrillary Tangles: Two Distinct Radioligand Binding Sites Identified in Postmortem Alzheimer's Disease Brain.
Topics: Alzheimer Disease; Aniline Compounds; Autoradiography; Binding Sites; Brain; Carbolines; Diagnosis; Dose-Response Relationship, Drug; Female; Humans; Male; Neurofibrillary Tangles; Positron-Emission Tomography; Quinolines; Radioligand Assay; Radiopharmaceuticals; tau Proteins; Thiazoles | 2016 |
Dynamic relationships between age, amyloid-β deposition, and glucose metabolism link to the regional vulnerability to Alzheimer's disease.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cerebral Cortex; Cohort Studies; Female; Fluorodeoxyglucose F18; Glucose; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Young Adult | 2016 |
Benzylpiperidine-Linked Diarylthiazoles as Potential Anti-Alzheimer's Agents: Synthesis and Biological Evaluation.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Butyrylcholinesterase; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Male; Mice; Molecular Structure; Piperidines; Rats; Rats, Wistar; Reactive Oxygen Species; Structure-Activity Relationship; Thiazoles; Tumor Cells, Cultured | 2016 |
Cholinergic Surveillance over Hippocampal RNA Metabolism and Alzheimer's-Like Pathology.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Disease Models, Animal; Embryo, Mammalian; Enzyme Inhibitors; Gene Expression Regulation; Glycogen Synthase Kinase 3; Hippocampus; Humans; Learning Disabilities; Mice; Mice, Inbred C57BL; Mice, Transgenic; RNA; Thiazoles; Thyroid Nuclear Factor 1; Urea; Vesicular Acetylcholine Transport Proteins | 2017 |
Impact of (18)FDG PET and (11)C-PIB PET brain imaging on the diagnosis of Alzheimer's disease and other dementias in a regional memory clinic in Hong Kong.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain; Dementia; Female; Fluorodeoxyglucose F18; Frontotemporal Dementia; Humans; Lewy Body Disease; Male; Positron-Emission Tomography; Radiopharmaceuticals; Retrospective Studies; Thiazoles | 2016 |
Intranasal Administration of a Polyethylenimine-Conjugated Scavenger Peptide Reduces Amyloid-β Accumulation in a Mouse Model of Alzheimer's Disease.
Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Benzothiazoles; Cell Line, Tumor; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Mutation; Neuroblastoma; Peptide Fragments; Polyethyleneimine; Positron-Emission Tomography; Presenilin-1; Thiazoles | 2016 |
Lower Late-Life Body-Mass Index is Associated with Higher Cortical Amyloid Burden in Clinically Normal Elderly.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Apolipoproteins E; Body Mass Index; Cerebral Cortex; Cross-Sectional Studies; Female; Geriatric Assessment; Humans; Linear Models; Male; Mental Status and Dementia Tests; Middle Aged; Positron-Emission Tomography; Thiazoles | 2016 |
Diagnostic role of 11C-Pittsburgh compound B retention patterns and glucose metabolism by fluorine-18-fluorodeoxyglucose PET/CT in amnestic and nonamnestic mild cognitive impairment patients.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Aniline Compounds; Brain; Carbon Radioisotopes; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Thiazoles | 2016 |
Fullerenol C60(OH)16 prevents amyloid fibrillization of Aβ40-in vitro and in silico approach.
Topics: Alzheimer Disease; Amyloid; Amyloidogenic Proteins; Benzothiazoles; Computer Simulation; Fullerenes; Thiazoles | 2016 |
Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzothiazoles; Biomarkers; Blotting, Western; Cell Line, Tumor; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Immunohistochemistry; Liver; Male; Mice; Middle Aged; Plaque, Amyloid; Receptor, Notch1; tau Proteins; Thiazoles | 2016 |
PiB-PET Imaging-Based Serum Proteome Profiles Predict Mild Cognitive Impairment and Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Blood Proteins; Chromatography, Liquid; Cognitive Dysfunction; Disease Progression; Enzyme-Linked Immunosorbent Assay; Factor XIII; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Peptides; Positron-Emission Tomography; Proprotein Convertase 9; Tandem Mass Spectrometry; Thiazoles | 2016 |
Imaging and cerebrospinal fluid biomarkers in early preclinical alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Disease Progression; Early Diagnosis; Female; Follow-Up Studies; Humans; Male; Middle Aged; Peptide Fragments; Prodromal Symptoms; Thiazoles | 2016 |
Automated PET-only quantification of amyloid deposition with adaptive template and empirically pre-defined ROI.
Topics: Algorithms; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2016 |
Age and neurodegeneration imaging biomarkers in persons with Alzheimer disease dementia.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Biomarkers; Cerebral Cortex; Female; Fluorodeoxyglucose F18; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2016 |
Polyphenols from wolfberry and their bioactivities.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzothiazoles; Biphenyl Compounds; Chlorogenic Acid; Cholinesterase Inhibitors; Flavonoids; Food Analysis; Free Radical Scavengers; Free Radicals; Lignans; Lycium; Molecular Structure; Oxygen; Picrates; Plant Extracts; Polyphenols; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thiazoles | 2017 |
A Robust and Efficient Production and Purification Procedure of Recombinant Alzheimers Disease Methionine-Modified Amyloid-β Peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Humans; Inclusion Bodies; Methionine; Peptide Fragments; Recombinant Proteins; Spectrophotometry, Ultraviolet; Staining and Labeling; Thiazoles | 2016 |
Association of Serum Docosahexaenoic Acid With Cerebral Amyloidosis.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Aniline Compounds; Brain Diseases; Cross-Sectional Studies; Docosahexaenoic Acids; Female; Humans; Male; Positron-Emission Tomography; Thiazoles | 2016 |
Rapid α-oligomer formation mediated by the Aβ C terminus initiates an amyloid assembly pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Peptide Fragments; Peptides; Protein Aggregation, Pathological; Protein Engineering; Protein Multimerization; Protein Structure, Secondary; Spectrum Analysis; Thiazoles; Time Factors | 2016 |
Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non-Alzheimer Disease Pathophysiology.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Disease Progression; Female; Hippocampus; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Prodromal Symptoms; tau Proteins; Thiazoles | 2016 |
Impact of spillover from white matter by partial volume effect on quantification of amyloid deposition with [
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Carbon Radioisotopes; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Thiazoles; White Matter | 2016 |
Positron emission tomography (PET) utilizing Pittsburgh compound B (PIB) for detection of amyloid heart deposits in hereditary transthyretin amyloidosis (ATTR).
Topics: Aged; Alzheimer Disease; Amyloid; Amyloid Neuropathies, Familial; Aniline Compounds; Biopsy; Brain; Carbon Radioisotopes; Echocardiography; Female; Healthy Volunteers; Heart; Heart Ventricles; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Radionuclide Imaging; Thiazoles | 2018 |
Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Benzothiazoles; Case-Control Studies; Cerebrospinal Fluid; Cholesterol, HDL; Chromatography, Gel; Female; Heterozygote; Humans; Immunoblotting; Kinetics; Male; Middle Aged; Peptide Fragments; Prospective Studies; Protein Multimerization; Thiazoles | 2016 |
Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Cognition Disorders; Female; Genome-Wide Association Study; Genotype; Humans; Longitudinal Studies; Male; Middle Aged; Neuropsychological Tests; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Risk Factors; tau Proteins; Thiazoles | 2017 |
Long-Term Cognitive Improvement After Benfotiamine Administration in Patients with Alzheimer's Disease.
Topics: Adjuvants, Immunologic; Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Chromatography, High Pressure Liquid; Cognition Disorders; Female; Humans; Longitudinal Studies; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Thiamine; Thiazoles | 2016 |
Defining imaging biomarker cut points for brain aging and Alzheimer's disease.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloidosis; Aniline Compounds; Brain; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Sensitivity and Specificity; Thiazoles | 2017 |
Anionic Oligothiophenes Compete for Binding of X-34 but not PIB to Recombinant Aβ Amyloid Fibrils and Alzheimer's Disease Brain-Derived Aβ.
Topics: Alkenes; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzoates; Brain; Humans; Positron-Emission Tomography; Thiazoles; Thiophenes | 2016 |
The feasibility of
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Brain Mapping; Feasibility Studies; Female; Humans; Magnetic Resonance Imaging; Male; Plaque, Amyloid; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Thiazoles | 2016 |
Cerebrospinal Fluid Aβ42/40 Corresponds Better than Aβ42 to Amyloid PET in Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Female; Humans; Logistic Models; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Thiazoles | 2017 |
Tau imaging with [
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain; Female; Humans; Male; Positron-Emission Tomography; Supranuclear Palsy, Progressive; tau Proteins; Thiazoles | 2017 |
Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloidosis; Aniline Compounds; Apolipoprotein E4; Cerebral Cortex; Female; Humans; Logistic Models; Loneliness; Male; Positron-Emission Tomography; Risk; Risk Factors; Statistics as Topic; Thiazoles | 2016 |
AV-1451 tau and β-amyloid positron emission tomography imaging in dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Carbolines; Case-Control Studies; Cerebral Cortex; Female; Humans; Lewy Body Disease; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Positron-Emission Tomography; tau Proteins; Thiazoles | 2017 |
Differences in Aβ brain networks in Alzheimer's disease and healthy controls.
Topics: Age Factors; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Body Weight; Brain; Brain Mapping; Cluster Analysis; Datasets as Topic; Female; Humans; Male; Neural Pathways; Positron-Emission Tomography; Radiopharmaceuticals; Regression Analysis; ROC Curve; Sex Factors; Signal Processing, Computer-Assisted; Thiazoles | 2017 |
Pittsburgh Compound-B (PiB) binds amyloid β-protein protofibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Brain; Disease Progression; Humans; Neurofibrillary Tangles; Positron-Emission Tomography; Protein Binding; tau Proteins; Thiazoles | 2017 |
Inter-rater variability of visual interpretation and comparison with quantitative evaluation of
Topics: Alzheimer Disease; Aniline Compounds; Benzothiazoles; Consensus; Female; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Neuroimaging; Observer Variation; Positron-Emission Tomography; Thiazoles | 2017 |
Detection and Quantification Methods for Fibrillar Products of In Vitro Tau Aggregation Assays.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Biological Assay; Humans; Microscopy, Electron; Protein Aggregation, Pathological; tau Proteins; Thiazoles | 2017 |
Quantitative Comparison of Dense-Core Amyloid Plaque Accumulation in Amyloid-β Protein Precursor Transgenic Mice.
Topics: Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Female; Hippocampus; Humans; Male; Mice, Transgenic; Plaque, Amyloid; Species Specificity; Thiazoles | 2017 |
An early and late peak in microglial activation in Alzheimer's disease trajectory.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Antineoplastic Agents; Brain Mapping; Carbon Radioisotopes; Cognition Disorders; Cohort Studies; Female; Humans; Imaging, Three-Dimensional; Isoquinolines; Magnetic Resonance Imaging; Male; Microglia; Middle Aged; Positron-Emission Tomography; Thiazoles | 2017 |
The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Aniline Compounds; Brain Diseases, Metabolic; Cerebral Cortex; Cross-Sectional Studies; Down Syndrome; Female; Gray Matter; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuroimaging; Thiazoles | 2017 |
Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid β.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Asymptomatic Diseases; Cognitive Dysfunction; Cohort Studies; Disease Progression; Female; Humans; Male; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Thiazoles | 2017 |
Fluorodeoxyglucose metabolism associated with tau-amyloid interaction predicts memory decline.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cerebral Cortex; Female; Fluorodeoxyglucose F18; Humans; Male; Memory Disorders; Palmitates; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; tau Proteins; Thiazoles; Thiones | 2017 |
Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Cognitive Dysfunction; Dendritic Spines; Female; Humans; Male; Microfilament Proteins; Nerve Tissue Proteins; Parietal Lobe; Plaque, Amyloid; Thiazoles | 2017 |
Cognitive Composites Domain Scores Related to Neuroimaging Biomarkers within Probable-Amnestic Mild Cognitive Impairment-Storage Subtype.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain; Cognitive Dysfunction; Female; Fluorodeoxyglucose F18; Humans; Magnetic Resonance Imaging; Male; Mental Recall; Neuroimaging; Neuropsychological Tests; Organ Size; Positron-Emission Tomography; Prodromal Symptoms; Radiopharmaceuticals; Survival Analysis; Thiazoles | 2017 |
Increased Pittsburgh Compound-B Accumulation in the Subcortical White Matter of Alzheimer's Disease Brain.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Carbon Radioisotopes; Case-Control Studies; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tissue Distribution; White Matter | 2017 |
Cerebrospinal Fluid Clearance in Alzheimer Disease Measured with Dynamic PET.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Case-Control Studies; Female; Humans; Male; Positron-Emission Tomography; Quinolines; Thiazoles | 2017 |
Amyloid-β Deposition and Long-Term Progression in Mild Cognitive Impairment due to Alzheimer's Disease Defined with Amyloid PET Imaging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Cognitive Dysfunction; Disease Progression; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Positron-Emission Tomography; Thiazoles | 2017 |
Simplified parametric methods for [11C]PIB studies.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Computer Simulation; Female; Humans; Image Interpretation, Computer-Assisted; Male; Middle Aged; Models, Biological; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles | 2008 |
Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Cognition Disorders; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Positron-Emission Tomography; Regression Analysis; Sensitivity and Specificity; Thiazoles | 2008 |
Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Basal Ganglia; Brain Mapping; Cerebral Cortex; Cognition Disorders; Female; Functional Laterality; Humans; Magnetic Resonance Imaging; Male; Nerve Fibers, Myelinated; Plaque, Amyloid; Positron-Emission Tomography; Staining and Labeling; Thiazoles | 2008 |
PET amyloid ligand [11C]PIB uptake shows predominantly striatal increase in variant Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain Mapping; Carbon Radioisotopes; Caudate Nucleus; Corpus Striatum; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2008 |
Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzothiazoles; Cerebral Amyloid Angiopathy; Dimerization; Disease Models, Animal; Humans; Mice; Mice, Transgenic; Plaque, Amyloid; Protein Conformation; Thiazoles | 2008 |
Different inhibitory response of cyanidin and methylene blue for filament formation of tau microtubule-binding domain.
Topics: Alzheimer Disease; Anthocyanins; Benzothiazoles; Cells, Cultured; Fluorescence; Fluorescent Dyes; Heparin; Humans; Methylene Blue; Microtubules; Protein Structure, Tertiary; tau Proteins; Thiazoles | 2008 |
Molecular polymorphism of Abeta in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Coloring Agents; Congo Red; Diagnostic Imaging; Disease Models, Animal; Humans; Ligands; Molecular Probes; Pathology, Molecular; Plaque, Amyloid; Predictive Value of Tests; Protein Isoforms; Thiazoles | 2010 |
Intracranial administration of vaccinia virus complement control protein in Mo/Hu APPswe PS1dE9 transgenic mice at an early age shows enhanced performance at a later age using a cheese board maze test.
Topics: Age Factors; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Association Learning; Behavior, Animal; Benzothiazoles; Complement System Proteins; Conditioning, Psychological; Disease Models, Animal; Genotype; Injections; Maze Learning; Mice; Mice, Transgenic; Reversal Learning; Space Perception; Thiazoles; Viral Proteins | 2008 |
Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aprotinin; Benzothiazoles; Humans; Microscopy, Electron; Prealbumin; Recombinant Proteins; Thiazoles | 2008 |
The ratio of monomeric to aggregated forms of Abeta40 and Abeta42 is an important determinant of amyloid-beta aggregation, fibrillogenesis, and toxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line; Humans; Microscopy, Electron, Transmission; Models, Biological; Neurons; Peptide Fragments; Peptides; Polymers; Protein Binding; Rats; Thiazoles; Time Factors | 2008 |
Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biopsy; Brain; Brain Mapping; Cross-Sectional Studies; Diagnosis, Differential; Disease Progression; Early Diagnosis; Female; Frontal Lobe; Humans; Hydrocephalus, Normal Pressure; Image Processing, Computer-Assisted; Intracranial Hypertension; Male; Neurofibrillary Tangles; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; tau Proteins; Thiazoles | 2008 |
Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Carbon Radioisotopes; Cerebral Cortex; Cluster Analysis; Cognition; Female; Humans; Isoquinolines; Magnetic Resonance Imaging; Male; Microglia; Middle Aged; Positron-Emission Tomography; Thiazoles | 2008 |
Appearance modeling of 11C PiB PET images: characterizing amyloid deposition in Alzheimer's disease, mild cognitive impairment and healthy aging.
Topics: Aged; Aging; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Cognition Disorders; Female; Humans; Image Processing, Computer-Assisted; Male; Models, Neurological; Neuropsychological Tests; Positron-Emission Tomography; Principal Component Analysis; Radiopharmaceuticals; Thiazoles | 2008 |
Beta-amyloid deposition and functional impairment in the retina of the APPswe/PS1DeltaE9 transgenic mouse model of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, Differentiation; Benzothiazoles; Choline O-Acetyltransferase; Disease Models, Animal; Electroretinography; Female; Fluorescent Antibody Technique, Indirect; Fluorescent Dyes; Glial Fibrillary Acidic Protein; Gliosis; Male; Mice; Mice, Transgenic; Microscopy, Confocal; Presenilin-1; Retina; Retinal Diseases; Syntaxin 1; Thiazoles | 2009 |
Aminostyrylbenzofuran derivatives as potent inhibitors for Abeta fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzofurans; Benzothiazoles; Benzoxazoles; Chemistry, Pharmaceutical; Curcumin; Drug Design; Electrons; Humans; Inhibitory Concentration 50; Models, Chemical; Peptide Fragments; Structure-Activity Relationship; Styrenes; Thiazoles | 2008 |
Abeta mediated diminution of MTT reduction--an artefact of single cell culture?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Electrophysiology; Hippocampus; Long-Term Potentiation; Male; Microglia; Neurons; Rats; Rats, Wistar; Synapses; Tetrazolium Salts; Thiazoles | 2008 |
Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Male; Microscopy, Confocal; Middle Aged; Neurofibrillary Tangles; Neurons; Organic Chemicals; Plaque, Amyloid; Postmortem Changes; Silver Staining; tau Proteins; Thiazoles | 2008 |
Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Flavonoids; Humans; Kinetics; L-Lactate Dehydrogenase; Microscopy, Electron; Models, Chemical; Molecular Conformation; Peptide Fragments; Peptides; Phenols; Polyphenols; Protein Conformation; Protein Isoforms; Protein Structure, Secondary; Thiazoles | 2008 |
Garlic extract exhibits antiamyloidogenic activity on amyloid-beta fibrillogenesis: relevance to Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Garlic; Humans; Microscopy, Electron, Transmission; Plant Extracts; Thiazoles | 2009 |
Biopsy support for the validity of Pittsburgh compound B positron emission tomography with a twist.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biopsy; Brain; Cognition Disorders; Diagnosis, Differential; Disease Progression; Early Diagnosis; False Negative Reactions; Humans; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Reproducibility of Results; Thiazoles | 2008 |
MR-less high dimensional spatial normalization of 11C PiB PET images on a population of elderly, mild cognitive impaired and Alzheimer disease patients.
Topics: Algorithms; Alzheimer Disease; Aniline Compounds; Artificial Intelligence; Benzothiazoles; Brain; Carbon Isotopes; Cognition Disorders; Computer Simulation; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Models, Biological; Models, Statistical; Pattern Recognition, Automated; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles | 2008 |
Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Aphasia, Primary Progressive; Carbon Isotopes; Dementia; Female; Fluorodeoxyglucose F18; Glucose; Humans; Image Processing, Computer-Assisted; Language; Language Tests; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2008 |
11C-labelled PIB analogues as potential tracer agents for in vivo imaging of amyloid beta in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Brain; Carbon Radioisotopes; Fluorine Radioisotopes; Humans; Hydroxides; Isomerism; Mice; Radioactive Tracers; Staining and Labeling; Thiazoles | 2009 |
Automated (11)C-PiB standardized uptake value ratio.
Topics: Aged; Algorithms; Alzheimer Disease; Aniline Compounds; Australia; Brain; Carbon Radioisotopes; Female; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Positron-Emission Tomography; ROC Curve; Thiazoles | 2008 |
Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Carbon Radioisotopes; Cognition; Educational Status; Female; Humans; Male; Middle Aged; Models, Psychological; Positron-Emission Tomography; Predictive Value of Tests; Psychiatric Status Rating Scales; Psychological Tests; Thiazoles | 2008 |
Docosahexaenoic acid disrupts in vitro amyloid beta(1-40) fibrillation and concomitantly inhibits amyloid levels in cerebral cortex of Alzheimer's disease model rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies; Benzothiazoles; Cerebral Cortex; Cholesterol; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Hippocampus; Microscopy, Electron, Transmission; Neurofibrillary Tangles; Peptide Fragments; Rats; Rats, Wistar; Thiazoles | 2008 |
Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Autopsy; Benzothiazoles; Blotting, Western; Cohort Studies; Cytoskeleton; Humans; Immunohistochemistry; Middle Aged; Neurofibrillary Tangles; Phosphorylation; Plaque, Amyloid; Presenilin-1; Severity of Illness Index; tau Proteins; Thiazoles | 2009 |
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Antioxidants; Ascorbic Acid; Benzothiazoles; Blotting, Western; Brain; Cerebral Ventricles; Cysteine; Dietary Supplements; Female; Glutathione; Hippocampus; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Plaque, Amyloid; Resveratrol; Sirtuin 1; Sirtuins; Stilbenes; tau Proteins; Thiazoles; Transcription Factors; Tumor Suppressor Protein p53 | 2009 |
Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects.
Topics: Age Factors; Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Carbon Radioisotopes; Case-Control Studies; Educational Status; Female; Hippocampus; Humans; Linear Models; Magnetic Resonance Imaging; Male; Memory Disorders; Middle Aged; Multivariate Analysis; Organ Size; Positron-Emission Tomography; Psychiatric Status Rating Scales; Radiopharmaceuticals; Sex Factors; Thiazoles | 2009 |
Microglial activation and amyloid deposition in mild cognitive impairment: a PET study.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain Mapping; Carbon Radioisotopes; Cognition Disorders; Female; Follow-Up Studies; Humans; Isoquinolines; Magnetic Resonance Imaging; Male; Microglia; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2009 |
Masked-Volume-Wise PCA and "reference Logan" illustrate similar regional differences in kinetic behavior in human brain PET study using [11C]-PIB.
Topics: Algorithms; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Follow-Up Studies; Humans; Kinetics; Models, Biological; Models, Statistical; Positron-Emission Tomography; Principal Component Analysis; Thiazoles | 2009 |
Design, selection, and characterization of thioflavin-based intercalation compounds with metal chelating properties for application in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Chelating Agents; Copper; Crystallography, X-Ray; Drug Design; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Iodine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Peptide Fragments; Thiazoles; Zinc | 2009 |
Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antineoplastic Agents; Brain; Carbon Radioisotopes; Cognition Disorders; Disease Progression; Encephalitis; Female; Gliosis; Humans; Isoquinolines; Male; Microglia; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles | 2009 |
AZD2184: a radioligand for sensitive detection of beta-amyloid deposits.
Topics: Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Autoradiography; Benzothiazoles; Brain; Carbon Radioisotopes; Competitive Bidding; Humans; Male; Mice; Mice, Transgenic; Mutation; Plaque, Amyloid; Positron-Emission Tomography; Presenilin-1; Protein Binding; Radioligand Assay; Rats; Rats, Sprague-Dawley; Thiazoles; Tritium | 2009 |
Characterization of PiB binding to white matter in Alzheimer disease and other dementias.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Case-Control Studies; Female; Humans; Immunohistochemistry; In Vitro Techniques; Lewy Body Disease; Male; Middle Aged; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2009 |
Detection of Alzheimer pathology in vivo using both 11C-PIB and 18F-FDDNP PET.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Case-Control Studies; Cerebral Cortex; Cognition Disorders; Female; Fluorine Radioisotopes; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nitriles; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2009 |
Synthesis and evaluation of 18F-labeled 2-phenylbenzothiazoles as positron emission tomography imaging agents for amyloid plaques in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Blood-Brain Barrier; Brain; Fluorine Radioisotopes; Humans; Male; Mice; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Wistar; Structure-Activity Relationship; Thiazoles; Tissue Distribution | 2009 |
nELAV proteins alteration in Alzheimer's disease brain: a novel putative target for amyloid-beta reverberating on AbetaPP processing.
Topics: ADAM Proteins; ADAM10 Protein; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Antigens, Surface; Brain; Case-Control Studies; Cell Cycle; Cell Line, Tumor; Disease Progression; ELAV Proteins; ELAV-Like Protein 1; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Humans; Male; Membrane Proteins; Neuroblastoma; Peptide Fragments; Postmortem Changes; RNA-Binding Proteins; RNA, Messenger; Tetrazolium Salts; Thiazoles | 2009 |
Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Cognition Disorders; Humans; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2009 |
An automated method for delineating a reference region using masked volumewise principal-component analysis in 11C-PIB PET.
Topics: Alzheimer Disease; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Cerebellum; Humans; Image Processing, Computer-Assisted; Positron-Emission Tomography; Principal Component Analysis; Thiazoles | 2009 |
Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Chi-Square Distribution; Female; Geriatric Assessment; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Pick Disease of the Brain; Positron-Emission Tomography; Thiazoles | 2009 |
Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Benzothiazoles; Brain; Brain Mapping; Carbon Radioisotopes; Female; Fluorodeoxyglucose F18; Humans; Linear Models; Magnetic Resonance Imaging; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Thiazoles | 2009 |
CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Cell Survival; Electrophoresis, Capillary; Humans; Isoquinolines; Microscopy, Electron, Transmission; Mitoxantrone; Neuroprotective Agents; Particle Size; Peptide Fragments; Plaque, Amyloid; Protein Multimerization; Spectrometry, Fluorescence; Suramin; Thiazoles | 2009 |
Involvement of protein trafficking in deprenyl-induced alpha-secretase activity regulation in PC12 cells.
Topics: ADAM Proteins; ADAM10 Protein; Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Brefeldin A; Cell Survival; Coloring Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Neuroprotective Agents; PC12 Cells; Protein Kinase C-alpha; Protein Kinase C-epsilon; Protein Transport; Rats; Selegiline; Tetrazolium Salts; Thiazoles; Time Factors | 2009 |
PIB binding in aged primate brain: enrichment of high-affinity sites in humans with Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Animals; Autoradiography; Brain; Cerebral Angiography; Enzyme-Linked Immunosorbent Assay; Female; Humans; Linear Models; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Primates; Protein Binding; tau Proteins; Thiazoles; Tritium | 2011 |
Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Brain; Carbon Radioisotopes; Case-Control Studies; Cognition Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Statistics, Nonparametric; Thiazoles; Time Factors | 2009 |
Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Apolipoproteins E; Benzothiazoles; Brain; Carbon Radioisotopes; DNA Mutational Analysis; Female; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Humans; Male; Middle Aged; Plaque, Amyloid; Polymorphism, Genetic; Positron-Emission Tomography; Risk Factors; Thiazoles | 2009 |
Visualization of brain amyloid and microglial activation in mouse models of Alzheimer's disease.
Topics: Acetamides; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Autoradiography; Brain; Brain Mapping; Disease Models, Animal; Humans; Isotopes; Mice; Mice, Transgenic; Microglia; Mutation; Phenyl Ethers; Positron-Emission Tomography; Protein Binding; tau Proteins; Thiazoles | 2009 |
Parcellation of human temporal polar cortex: a combined analysis of multiple cytoarchitectonic, chemoarchitectonic, and pathological markers.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antigens, Nuclear; Benzothiazoles; Female; Histocytochemistry; Humans; Immunohistochemistry; Male; Nerve Tissue Proteins; Plant Lectins; Pyramidal Cells; Receptors, N-Acetylglucosamine; Tauopathies; Temporal Lobe; Thiazoles | 2009 |
Test-retest variability of quantitative [11C]PIB studies in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Case-Control Studies; Cerebellum; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles | 2009 |
In vivo mapping of amyloid toxicity in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amygdala; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Benzothiazoles; Brain; Female; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2009 |
Comparison of 18F-FDG and PiB PET in cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Cognition Disorders; Fluorodeoxyglucose F18; Humans; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2009 |
Principal component analysis with pre-normalization improves the signal-to-noise ratio and image quality in positron emission tomography studies of amyloid deposits in Alzheimer's disease.
Topics: Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Humans; Image Enhancement; Image Processing, Computer-Assisted; Kinetics; Positron-Emission Tomography; Principal Component Analysis; Thiazoles | 2009 |
Comparative study of inhibition at multiple stages of amyloid-beta self-assembly provides mechanistic insight.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Inhibitory Concentration 50; Light; Molecular Structure; Peptide Fragments; Protein Binding; Protein Conformation; Quinolizines; Scattering, Radiation; Solubility; Spectrometry, Fluorescence; Structure-Activity Relationship; Thiazoles | 2009 |
Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Case-Control Studies; Cerebellum; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles | 2009 |
D-Ribosylated Tau forms globular aggregates with high cytotoxicity.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Cell Line; Fluorescent Dyes; Glycosylation; Humans; Microscopy, Atomic Force; Molecular Sequence Data; Neurofibrillary Tangles; Protein Conformation; Ribose; tau Proteins; Thiazoles | 2009 |
Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Hippocampus; Humans; Memory; Memory Disorders; Mice; Mice, Transgenic; Organ Size; Peptide Fragments; Physical Conditioning, Animal; Protease Nexins; Random Allocation; Receptors, Cell Surface; Recognition, Psychology; Thiazoles; Time Factors | 2009 |
Comparison study of amyloid PET and voxel-based morphometry analysis in mild cognitive impairment and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzoxazoles; Brain; Carbon Radioisotopes; Cognition Disorders; Early Diagnosis; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Neocortex; Nerve Fibers, Unmyelinated; Neuropsychological Tests; Parahippocampal Gyrus; Plaque, Amyloid; Positron-Emission Tomography; Severity of Illness Index; Signal Processing, Computer-Assisted; Thiazoles | 2009 |
Inhibition of Abeta42 aggregation using peptides selected from combinatorial libraries.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Drug Evaluation, Preclinical; Molecular Sequence Data; Peptide Library; Peptides; Thiazoles | 2009 |
In vitro characterisation of BF227 binding to alpha-synuclein/Lewy bodies.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Benzoxazoles; Brain; Fluorine Radioisotopes; Humans; Immunohistochemistry; Lewy Bodies; Lewy Body Disease; Peptide Fragments; Protein Binding; Substrate Specificity; Thiazoles | 2009 |
Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study.
Topics: Aged; Alzheimer Disease; Amnesia; Aniline Compounds; Carbon Radioisotopes; Cognition Disorders; Disease Progression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles; Time Factors | 2009 |
Strategies for the generation of parametric images of [11C]PIB with plasma input functions considering discriminations and reproducibility.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Brain; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Plasma; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles; Time Factors | 2009 |
Mechanism of docosahexaenoic acid-induced inhibition of in vitro Abeta1-42 fibrillation and Abeta1-42-induced toxicity in SH-S5Y5 cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Docosahexaenoic Acids; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; In Vitro Techniques; Microscopy, Confocal; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Neurofibrillary Tangles; Peptide Fragments; Spectrum Analysis; Thiazoles | 2009 |
Relationship of cerebrospinal fluid markers to 11C-PiB and 18F-FDDNP binding.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Biomarkers; Brain; Cognition Disorders; Female; Humans; Male; Nitriles; Peptide Fragments; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Statistics as Topic; tau Proteins; Thiazoles; Tissue Distribution | 2009 |
Deficient high-affinity binding of Pittsburgh compound B in a case of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autoradiography; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Immunoprecipitation; Microscopy, Electron, Transmission; Positron-Emission Tomography; Radiopharmaceuticals; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Tritium | 2010 |
Imaging and biomarkers in early Alzheimer's disease and mild cognitive impairment.
Topics: Alzheimer Disease; Aniline Compounds; Biomarkers; Brain; Humans; Magnetic Resonance Imaging; Positron-Emission Tomography; Thiazoles | 2009 |
Follow-up of [11C]PIB uptake and brain volume in patients with Alzheimer disease and controls.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Carbon Radioisotopes; Case-Control Studies; Cognition; Disease Progression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Organ Size; Radionuclide Imaging; Thiazoles | 2009 |
Oligomers of beta-amyloid are sequestered into and seed new plaques in the brains of an AD mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotin; Disease Models, Animal; Humans; Immunohistochemistry; Islet Amyloid Polypeptide; Ligands; Male; Mice; Mice, Transgenic; Microscopy, Atomic Force; Molecular Weight; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2010 |
Copper abolishes the beta-sheet secondary structure of preformed amyloid fibrils of amyloid-beta(42).
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Birefringence; Congo Red; Copper; Fluorescent Dyes; Humans; Microscopy, Electron, Transmission; Peptide Fragments; Peptides; Protein Structure, Secondary; Thiazoles | 2009 |
Switching to duloxetine remits ziprasidone - associated urinary incontinence and improves neuropsychiatric behavior in dementia: possible relationship of incontinence to 5HT2 receptor blockade.
Topics: Aged, 80 and over; Alzheimer Disease; Dementia, Vascular; Duloxetine Hydrochloride; Humans; Male; Parkinsonian Disorders; Piperazines; Receptors, Serotonin, 5-HT2; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Thiazoles; Thiophenes; Urinary Incontinence | 2009 |
Immunohistochemical analysis of human brain suggests pathological synergism of Alzheimer's disease and diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Cell Count; Diabetes Mellitus; Female; Fluorescent Antibody Technique; Glycation End Products, Advanced; Humans; Immunohistochemistry; Male; Microglia; Middle Aged; Peptide Fragments; Plant Lectins; Plaque, Amyloid; Receptor for Advanced Glycation End Products; Receptors, Immunologic; tau Proteins; Thiazoles | 2010 |
Glucose metabolism and PIB binding in carriers of a His163Tyr presenilin 1 mutation.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Blood Glucose; Carbon Radioisotopes; Corpus Striatum; Female; Humans; Male; Middle Aged; Point Mutation; Positron-Emission Tomography; Presenilin-1; Thiazoles | 2011 |
Relationships between biomarkers in aging and dementia.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Case-Control Studies; Cognition Disorders; Female; Fluorodeoxyglucose F18; Humans; Male; Peptide Fragments; Positron-Emission Tomography; Psychiatric Status Rating Scales; tau Proteins; Thiazoles | 2009 |
Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Brain Mapping; Female; Geriatric Assessment; Humans; Image Processing, Computer-Assisted; Longitudinal Studies; Magnetic Resonance Imaging; Male; Nerve Net; Oxygen; Positron-Emission Tomography; Psychiatric Status Rating Scales; Rest; Statistics as Topic; Thiazoles | 2010 |
Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Cholesterol; Fluorescence; Kinetics; Light; Microscopy, Immunoelectron; Molecular Sequence Data; Mutagenesis, Site-Directed; Neurons; Oxidation-Reduction; Peptides; Protein Structure, Quaternary; Rats; Scattering, Radiation; Thiazoles | 2009 |
A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Astrocytes; Brain; Cell Line; Cells, Cultured; Disease Models, Animal; Encephalitis; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Mice; Mice, Transgenic; Mutation; Neprilysin; Neurons; Plaque, Amyloid; PPAR delta; Presenilin-1; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Thiazoles; Transfection | 2009 |
Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Carbon Radioisotopes; Cerebral Cortex; Family Health; Humans; Peptide Fragments; Positron-Emission Tomography; tau Proteins; Thiazoles | 2010 |
RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aptamers, Nucleotide; Benzothiazoles; Densitometry; Dimerization; DNA, Single-Stranded; Humans; Ligands; Peptide Fragments; Protein Binding; Protein Folding; Protein Structure, Secondary; Thiazoles | 2009 |
Up-regulation of the type 3 ryanodine receptor is neuroprotective in the TgCRND8 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Calcium; Cell Death; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glutamic Acid; Green Fluorescent Proteins; Humans; Mice; Mice, Transgenic; Mutation; Neurons; Peptide Fragments; Phosphopyruvate Hydratase; Potassium; Presenilin-1; RNA, Messenger; RNA, Small Interfering; Ryanodine Receptor Calcium Release Channel; Tetrazolium Salts; Thiazoles; Up-Regulation | 2010 |
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line, Tumor; Cytoplasmic Vesicles; Fluorescence; Humans; Immunoblotting; Mice; Microscopy, Confocal; Neurons; Plaque, Amyloid; Thiazoles | 2009 |
Amyloid PET in mild cognitive impairment and Alzheimer's disease with BF-227: comparison to FDG-PET.
Topics: Aged; Alzheimer Disease; Amyloid; Benzoxazoles; Brain; Brain Mapping; Carbon Radioisotopes; Cognition Disorders; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Plaque, Amyloid; Positron-Emission Tomography; ROC Curve; Sensitivity and Specificity; Thiazoles | 2010 |
Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Carbon Radioisotopes; Cognition; Cognition Disorders; Cohort Studies; Disease Progression; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Middle Aged; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles | 2009 |
Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Carbon Radioisotopes; Cerebral Cortex; Cognition Disorders; Follow-Up Studies; Humans; Longitudinal Studies; Organ Size; Peptide Fragments; Protein Binding; Radionuclide Imaging; Thiazoles | 2009 |
Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report.
Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Carbon Radioisotopes; Cerebral Cortex; Cognition Disorders; Follow-Up Studies; Humans; Longitudinal Studies; Male; Radionuclide Imaging; Thiazoles | 2009 |
Differential association of [11C]PIB and [18F]FDDNP binding with cognitive impairment.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Brain; Carbon Radioisotopes; Cognition Disorders; Female; Fluorine Radioisotopes; Humans; Linear Models; Magnetic Resonance Imaging; Male; Mental Recall; Middle Aged; Neuropsychological Tests; Nitriles; Positron-Emission Tomography; Regression Analysis; Thiazoles | 2009 |
Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Cerebellar Cortex; Female; Humans; Male; Middle Aged; Neurofibrillary Tangles; Positron-Emission Tomography; Protein Binding; Thiazoles | 2009 |
Pittsburgh compound B binding in poststroke dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Binding, Competitive; Biomarkers; Brain; Cognition Disorders; Dementia, Vascular; Disability Evaluation; Female; Humans; Male; Neuropsychological Tests; Pilot Projects; Positron-Emission Tomography; Predictive Value of Tests; Severity of Illness Index; Stroke; Thiazoles | 2010 |
Critical role of interfaces and agitation on the nucleation of Abeta amyloid fibrils at low concentrations of Abeta monomers.
Topics: Air; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Brain Chemistry; Fluorescent Dyes; Humans; In Vitro Techniques; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Neurodegenerative Diseases; Peptide Fragments; Protein Binding; Protein Conformation; Protein Multimerization; Solutions; Spectrometry, Fluorescence; Thiazoles; Water | 2010 |
2-(1-{6-[(2-[fluorine-18]fluoroethyl)(methyl) amino]-2-naphthyl} ethylidene)malononitrile (FDDNP) positron emission tomography patterns in nondemented populations.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Cognition Disorders; Female; Humans; Male; Middle Aged; Neurofibrillary Tangles; Nitriles; Plaque, Amyloid; Positron-Emission Tomography; Temporal Lobe; Thiazoles | 2010 |
The therapeutic effects of the herbal medicine, Juzen-taiho-to, on amyloid-beta burden in a mouse model of Alzheimer's disease.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Antipsychotic Agents; Benzothiazoles; Bone Marrow Cells; Calcium-Binding Proteins; Cell Culture Techniques; Cytokines; Disease Models, Animal; DNA-Binding Proteins; Drugs, Chinese Herbal; Flow Cytometry; Gene Expression Regulation; Humans; Ki-67 Antigen; Macrophages; Mice; Mice, Transgenic; Microfilament Proteins; Mutation; Thiazoles | 2010 |
APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E2; Apolipoprotein E4; Apolipoproteins E; Brain; Female; Follow-Up Studies; Genotype; Humans; Longitudinal Studies; Male; Middle Aged; Peptide Fragments; Phosphorylation; Plaque, Amyloid; tau Proteins; Thiazoles | 2010 |
Density functional theory analysis and spectral studies on amyloid peptide Abeta(28-35) and its mutants A30G and A30I.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; In Vitro Techniques; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Peptide Fragments; Protein Conformation; Protein Stability; Protein Structure, Secondary; Spectrometry, Fluorescence; Static Electricity; Thermodynamics; Thiazoles | 2010 |
Testing the amyloid hypothesis of Alzheimer's disease in vivo.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Biomarkers; Brain; Genetic Predisposition to Disease; Humans; Immunization, Passive; Immunologic Factors; Models, Neurological; Positron-Emission Tomography; Thiazoles; Treatment Outcome | 2010 |
High PIB retention in Alzheimer's disease is an early event with complex relationship with CSF biomarkers and functional parameters.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Biomarkers; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; Female; Fluorodeoxyglucose F18; Glucose; Humans; Image Interpretation, Computer-Assisted; Male; Memory Disorders; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2010 |
Development of a proteolytically stable retro-inverso peptide inhibitor of beta-amyloid oligomerization as a potential novel treatment for Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Aggregation; Cell Line; Cell Survival; Humans; Immunoassay; Molecular Sequence Data; Peptide Fragments; Peptides; Surface Plasmon Resonance; Thiazoles | 2010 |
Increased fibrillar amyloid-{beta} burden in normal individuals with a family history of late-onset Alzheimer's.
Topics: Age of Onset; Aged; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Case-Control Studies; Cohort Studies; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2010 |
Pittsburgh compound-B and Alzheimer's disease biomarkers in CSF, plasma and urine: An exploratory study.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Biomarkers; Brain; Cognition; Data Interpretation, Statistical; Education; Enzyme-Linked Immunosorbent Assay; Female; Glucose; Humans; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Psychometrics; Radiopharmaceuticals; Risk Factors; Thiazoles | 2010 |
Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Calpain; Coloring Agents; Cyclin-Dependent Kinase 5; Glutamic Acid; Humans; Immunohistochemistry; MAP Kinase Kinase 6; Mice; Mice, Transgenic; Neurons; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Signal Transduction; Tetrazolium Salts; Thiazoles | 2010 |
Burden of neurodegenerative diseases in a cohort of medical examiner subjects.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Atrophy; Benzothiazoles; Brain; Brain Edema; Cohort Studies; Coroners and Medical Examiners; Female; Forensic Pathology; Frontotemporal Lobar Degeneration; Humans; Hygiene; Ill-Housed Persons; Immunohistochemistry; Male; Malnutrition; Middle Aged; Neurofibrillary Tangles; Neuropil Threads; Plaque, Amyloid; Staining and Labeling; Tauopathies; Thiazoles; Young Adult | 2010 |
Abeta20-29 peptide blocking apoE/Abeta interaction reduces full-length Abeta42/40 fibril formation and cytotoxicity in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Benzothiazoles; Cell Survival; Cells, Cultured; Fluorescent Dyes; Humans; Microscopy, Electron; Neurofibrils; Peptide Fragments; Spectrometry, Fluorescence; Tetrazolium Salts; Thiazoles | 2010 |
Relationship between atrophy and beta-amyloid deposition in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Benzothiazoles; Biomarkers; Brain; Cognition Disorders; Disease Progression; Female; Humans; Magnetic Resonance Imaging; Male; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Prognosis; Severity of Illness Index; Thiazoles | 2010 |
Cognition, reserve, and amyloid deposition in normal aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Cognition; Cognition Disorders; Disability Evaluation; Disease Progression; Female; Humans; Longitudinal Studies; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Reference Values; Severity of Illness Index; Thiazoles | 2010 |
Voxel-based analysis of Alzheimer's disease PET imaging using a triplet of radiotracers: PIB, FDDNP, and FDG.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Brain; Brain Mapping; Case-Control Studies; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Neurofibrillary Tangles; Nitriles; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Signal Processing, Computer-Assisted; Thiazoles | 2010 |
Laser-induced propagation and destruction of amyloid beta fibrils.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; beta 2-Microglobulin; Humans; Kinetics; Lasers; Models, Biological; Peptide Fragments; Peptides; Photochemotherapy; Protein Folding; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Ultracentrifugation | 2010 |
Pittsburgh compound B (11C-PIB) and fluorodeoxyglucose (18 F-FDG) PET in patients with Alzheimer disease, mild cognitive impairment, and healthy controls.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Area Under Curve; Brain; Cerebellum; Chromatography, High Pressure Liquid; Cognition Disorders; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Memory; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; ROC Curve; Thiazoles | 2010 |
Curcumin labeling of neuronal fibrillar tau inclusions in human brain samples.
Topics: Alzheimer Disease; Benzothiazoles; Brain Diseases; Curcumin; Humans; Neurofibrillary Tangles; Neurons; Pick Disease of the Brain; Silver Staining; Supranuclear Palsy, Progressive; tau Proteins; Tauopathies; Thiazoles | 2010 |
[Positron emission tomography imaging of cell transplantation in a rat model of Alzheimer's disease].
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Fluorodeoxyglucose F18; Male; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Stem Cell Transplantation; Thiazoles | 2010 |
The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Brain Mapping; Cohort Studies; Female; Fluorodeoxyglucose F18; Humans; Imaging, Three-Dimensional; Male; Positron-Emission Tomography; Retrospective Studies; Thiazoles | 2010 |
Addressing population aging and Alzheimer's disease through the Australian imaging biomarkers and lifestyle study: collaboration with the Alzheimer's Disease Neuroimaging Initiative.
Topics: Aging; Alzheimer Disease; Aniline Compounds; Australia; Biomarkers; Diagnostic Imaging; Humans; Life Style; Longitudinal Studies; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2010 |
Alzheimer's disease: spect and pet tracers for beta-amyloid imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain Mapping; Cerebral Cortex; Congo Red; Fluorodeoxyglucose F18; Humans; Neurofibrillary Tangles; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2010 |
Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Australia; Biomarkers; Cohort Studies; Echo-Planar Imaging; Female; Genetic Carrier Screening; Hippocampus; Humans; Longitudinal Studies; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Prospective Studies; Risk Reduction Behavior; Thiazoles | 2010 |
[The effect of meloxicam on the inflammatory reaction induced by beta amyloid protein in Alzheimer's disease rats].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cerebral Cortex; Glial Fibrillary Acidic Protein; Inflammation; Interleukin-1beta; Male; Meloxicam; Peptide Fragments; Rats; Rats, Sprague-Dawley; Thiazines; Thiazoles; Transcription Factor RelA; Tumor Necrosis Factor-alpha | 2010 |
Substoichiometric inhibition of Abeta(1-40) aggregation by a tandem Abeta(40-1-Gly8-1-40) peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Fluorescent Dyes; Humans; Microscopy, Atomic Force; Peptide Fragments; Peptides; Thiazoles | 2010 |
3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Atrophy; Biomarkers; Carbon Radioisotopes; Cohort Studies; Female; Follow-Up Studies; Hippocampus; Humans; Imaging, Three-Dimensional; Longitudinal Studies; Male; Peptide Fragments; Positron-Emission Tomography; Prospective Studies; tau Proteins; Thiazoles | 2010 |
Molecular imaging in the diagnosis of Alzheimer's disease: visual assessment of [11C]PIB and [18F]FDDNP PET images.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Atrophy; Benzothiazoles; Brain Chemistry; Female; Fluorodeoxyglucose F18; Glucose; Humans; Image Processing, Computer-Assisted; Likelihood Functions; Magnetic Resonance Imaging; Male; Middle Aged; Nitriles; Observer Variation; Positron-Emission Tomography; Radiopharmaceuticals; ROC Curve; Temporal Lobe; Thiazoles | 2010 |
Synthesis and biodistribution of [11C]A-836339, a new potential radioligand for PET imaging of cannabinoid type 2 receptors (CB2).
Topics: Alzheimer Disease; Amyloidosis; Animals; Brain; Carbon Radioisotopes; Female; Inflammation; Male; Mice; Positron-Emission Tomography; Receptor, Cannabinoid, CB2; Thiazoles | 2010 |
Progression of cerebral amyloid load is associated with the apolipoprotein E ε4 genotype in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Apolipoprotein E4; Brain; Disease Progression; Female; Fluorodeoxyglucose F18; Genotype; Humans; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2010 |
Dynamic changes in PET amyloid and FDG imaging at different stages of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Cognition; Cognitive Dysfunction; Disease Progression; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Follow-Up Studies; Glucose; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Time Factors | 2012 |
Third degree heart block following intramuscular ziprasidone.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Bradycardia; Cardiopulmonary Resuscitation; Dementia, Vascular; Dose-Response Relationship, Drug; Female; Heart Block; Hospitalization; Humans; Injections, Intramuscular; Long QT Syndrome; Piperazines; Schizophrenia, Paranoid; Thiazoles | 2011 |
Positron emission tomography with Pittsburgh compound B in diagnosis of early stage Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Carbon Radioisotopes; Cognition Disorders; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2011 |
Attenuated antiaggregation effects of magnetite nanoparticles in cerebrospinal fluid of people with Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Benzothiazoles; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Fluorescence; Humans; Magnetite Nanoparticles; Male; Nanomedicine; Protein Structure, Quaternary; Thiazoles | 2010 |
Voxel-based analysis of amyloid positron emission tomography probe [C]BF-227 uptake in mild cognitive impairment and alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzoxazoles; Carbon Radioisotopes; Cerebral Cortex; Data Interpretation, Statistical; Disease Progression; Educational Status; Evidence-Based Medicine; Female; Humans; Male; Plaque, Amyloid; Positron-Emission Tomography; Sex Factors; Thiazoles; Wechsler Scales | 2010 |
Reduction of hippocampal N-acetyl aspartate level in aged APP(Swe)/PS1(dE9) transgenic mice is associated with degeneration of CA3 pyramidal neurons.
Topics: Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Aspartic Acid; Benzothiazoles; CA1 Region, Hippocampal; Creatine; Disease Models, Animal; Down-Regulation; Female; Humans; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Nerve Degeneration; Plaque, Amyloid; Presenilin-1; Pyramidal Cells; Thiazoles | 2010 |
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Benzothiazoles; Biophysics; Fluorescent Dyes; Humans; Kinetics; Mice; Microelectrodes; Microscopy, Electron, Transmission; Neurons; Patch-Clamp Techniques; Peptide Fragments; Plaque, Amyloid; Protein Binding; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2010 |
Exercise and Alzheimer's disease biomarkers in cognitively normal older adults.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Exercise; Female; Geriatric Assessment; Humans; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Psychiatric Status Rating Scales; Risk Factors; tau Proteins; Thiazoles | 2010 |
Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Brain Chemistry; Cerebral Cortex; Chlamydia Infections; Chlamydophila pneumoniae; Coloring Agents; Female; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Plaque, Amyloid; Reproducibility of Results; Thiazoles; Tissue Banks | 2010 |
Arylsulfonamidothiazoles for the early stages of Alzheimer type dementia: a new potential for treatment.
Topics: Alzheimer Disease; Humans; Sulfonamides; Thiazoles | 2011 |
Olfactory deficits and amyloid-β burden in Alzheimer's disease, mild cognitive impairment, and healthy aging: a PiB PET study.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Brain Mapping; Cognition Disorders; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Olfaction Disorders; Olfactory Perception; Radionuclide Imaging; Thiazoles | 2010 |
Synthesis and biological evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one derivatives as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Cholinesterase Inhibitors; Databases, Protein; GPI-Linked Proteins; Humans; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Protein Binding; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Structure-Activity Relationship; Thiazoles; Torpedo; Triazines | 2010 |
Carbon-11-Pittsburgh compound B positron emission tomography imaging of amyloid deposition in presenilin 1 mutation carriers.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Brain Mapping; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Mutation; Neuropsychological Tests; Positron-Emission Tomography; Presenilin-1; Thiazoles | 2011 |
I32E and V36K double mutation in beta2-sheet abrogates amyloid beta peptide toxicity.
Topics: Alzheimer Disease; Alzheimer Vaccines; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Antibody Specificity; Benzothiazoles; Cell Shape; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Humans; Molecular Sequence Data; Mutation; Protein Binding; Rabbits; Thiazoles | 2010 |
Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Disease Progression; Female; Humans; Middle Aged; Neurofibrillary Tangles; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2011 |
Interactions of Npc1 and amyloid accumulation/deposition in the APP/PS1 mouse model of Alzheimer's.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Peptide Fragments; Plaque, Amyloid; Proteins; Regression Analysis; Thiazoles | 2011 |
Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Atrophy; Brain; Data Interpretation, Statistical; Female; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Observer Variation; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles | 2011 |
Early 11C-PIB frames and 18F-FDG PET measures are comparable: a study validated in a cohort of AD and FTLD patients.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Cohort Studies; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Frontotemporal Dementia; Humans; Logistic Models; Male; Middle Aged; Models, Statistical; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Thiazoles; Time Factors | 2011 |
High ability of apolipoprotein E4 to stabilize amyloid-β peptide oligomers, the pathological entities responsible for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E3; Apolipoprotein E4; Benzothiazoles; Blotting, Western; Electrophoresis; Humans; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2011 |
Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Cognition; Cognition Disorders; Disease Progression; Female; Follow-Up Studies; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Plaque, Amyloid; Polymorphism, Genetic; Positron-Emission Tomography; Severity of Illness Index; Thiazoles | 2011 |
Transforming cerebrospinal fluid Aβ42 measures into calculated Pittsburgh Compound B units of brain Aβ amyloid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Humans; Nonlinear Dynamics; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2011 |
Two cases of dementias with motor neuron disease evaluated by Pittsburgh compound B-positron emission tomography.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Brain; Diagnosis, Differential; Female; Frontotemporal Dementia; Humans; Male; Middle Aged; Motor Neuron Disease; Positron-Emission Tomography; Thiazoles | 2012 |
Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Brain Mapping; Carbon Radioisotopes; Cognition Disorders; Female; Humans; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Memory Disorders; Middle Aged; Positron-Emission Tomography; Regression Analysis; Thiazoles | 2011 |
Amyloid PET imaging in patients with mild cognitive impairment: a 2-year follow-up study.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Brain; Carbon Radioisotopes; Cognition Disorders; Disease Progression; Female; Follow-Up Studies; Humans; Male; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2011 |
Sequence-independent control of peptide conformation in liposomal vaccines for targeting protein misfolding diseases.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Circular Dichroism; Female; Humans; Immunoglobulin G; Liposomes; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Peptides; Protein Conformation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Proteostasis Deficiencies; Thiazoles; Vaccines | 2011 |
Oxidative biaryl coupling of thiophenes and thiazoles with arylboronic acids through palladium catalysis: otherwise difficult C4-selective C-H arylation enabled by boronic acids.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Boronic Acids; Carbon; Catalysis; Cyclic N-Oxides; Humans; Hydrogen; Oxidation-Reduction; Palladium; Protease Inhibitors; Stereoisomerism; Thiazoles; Thiophenes | 2011 |
The effect of tachykinin neuropeptides on amyloid β aggregation.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Fluorescent Dyes; Humans; Peptide Fragments; Protein Structure, Secondary; Tachykinins; Thiazoles | 2011 |
The Osaka FAD mutation E22Δ leads to the formation of a previously unknown type of amyloid β fibrils and modulates Aβ neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Humans; Mutation; Neurons; Neurotoxins; Rats; Thiazoles | 2011 |
Using positron emission tomography and Carbon 11-labeled Pittsburgh Compound B to image Brain Fibrillar β-amyloid in adults with down syndrome: safety, acceptability, and feasibility.
Topics: Adult; Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain; Brain Mapping; Down Syndrome; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Thiazoles; Young Adult | 2011 |
Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Apolipoproteins E; Biomarkers; Brain; Carbon Radioisotopes; Cognition Disorders; Cross-Sectional Studies; Heterozygote; Homozygote; Humans; Positron-Emission Tomography; Risk Factors; Thiazoles | 2011 |
In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
Topics: Acetamides; Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Autoradiography; Brain; Humans; Immunohistochemistry; Isotope Labeling; Magnetic Resonance Imaging; Mice; Mice, Inbred C57BL; Neuritis; Neuroglia; Pick Disease of the Brain; Plaque, Amyloid; Positron-Emission Tomography; Purines; Radiopharmaceuticals; Receptors, GABA; Supranuclear Palsy, Progressive; tau Proteins; Thiazoles | 2011 |
Amyloid-β associated cortical thinning in clinically normal elderly.
Topics: Age Factors; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Brain Mapping; Cerebral Cortex; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Statistics as Topic; Thiazoles | 2011 |
Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Humans; Nitrogen Oxides; Oxidation-Reduction; Spectrometry, Fluorescence; Spin Labels; Thiazoles | 2011 |
Calcium ions promote formation of amyloid β-peptide (1-40) oligomers causally implicated in neuronal toxicity of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Calcium; Fluorescence; Humans; Ions; Models, Biological; Mutant Proteins; Neurons; Protein Structure, Quaternary; Protein Structure, Secondary; Spectroscopy, Fourier Transform Infrared; Thiazoles | 2011 |
Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain Mapping; Cerebral Cortex; Cognition Disorders; Female; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Oxygen; Positron-Emission Tomography; Statistics as Topic; Thiazoles | 2011 |
Cognition and beta-amyloid in preclinical Alzheimer's disease: data from the AIBL study.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Case-Control Studies; Cerebral Cortex; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Early Diagnosis; Female; Humans; Longitudinal Studies; Male; Middle Aged; Neuropsychological Tests; Radionuclide Imaging; Reference Values; Sex Factors; Thiazoles | 2011 |
Cerebral amyloid angiopathy in streptozotocin rat model of sporadic Alzheimer's disease: a long-term follow up study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibiotics, Antineoplastic; Benzothiazoles; Cerebral Amyloid Angiopathy; Disease Models, Animal; Disease Progression; Longitudinal Studies; Male; Peptide Fragments; Rats; Rats, Wistar; Staining and Labeling; Streptozocin; Thiazoles | 2011 |
Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB).
Topics: Alzheimer Disease; Aniline Compounds; Automation, Laboratory; Benzothiazoles; Carbon Radioisotopes; Humans; Isotope Labeling; Plaque, Amyloid; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2011 |
A standardized and biocompatible preparation of aggregate-free amyloid beta peptide for biophysical and biological studies of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biomedical Research; Cell Line, Tumor; Cytological Techniques; Humans; Indicators and Reagents; Kinetics; Microscopy, Electron, Transmission; Nuclear Magnetic Resonance, Biomolecular; Reproducibility of Results; Solubility; Spectrometry, Fluorescence; Thiazoles | 2011 |
Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Blood-Brain Barrier; Contrast Media; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Kinetics; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Molecular Targeted Therapy; Mutagenesis, Site-Directed; Peptide Fragments; Peptide Library; Peptides, Cyclic; Plaque, Amyloid; Protein Binding; Sequence Analysis, DNA; Thiazoles | 2011 |
Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration.
Topics: Administration, Oral; Alzheimer Disease; Animals; Brain Chemistry; Disease Models, Animal; Female; Humans; Huntington Disease; Kynurenic Acid; Kynurenine 3-Monooxygenase; Male; Mice; Mice, Transgenic; Sulfonamides; Thiazoles | 2011 |
Resolution of localized small molecule-Aβ interactions by deep-ultraviolet resonance Raman spectroscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Flavonoids; Humans; Peptide Fragments; Protein Binding; Protein Structure, Secondary; Spectrum Analysis, Raman; Thiazoles | 2011 |
Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau-driven models of Alzheimer's disease.
Topics: Alzheimer Disease; Cell Line; Humans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Models, Biological; Neurons; tau Proteins; Thiazoles | 2011 |
Cerebral serotonin 4 receptors and amyloid-β in early Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Brain Chemistry; Cognition; Female; Humans; Image Processing, Computer-Assisted; Ligands; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Receptors, Serotonin, 5-HT4; Thiazoles | 2011 |
Regional expansion of hypometabolism in Alzheimer's disease follows amyloid deposition with temporal delay.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Biomarkers; Brain; Case-Control Studies; Female; Fluorodeoxyglucose F18; Functional Neuroimaging; Humans; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Time Factors | 2012 |
Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity.
Topics: Age Factors; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Benzothiazoles; Brain; Cholinergic Agents; Enzyme-Linked Immunosorbent Assay; Female; Genotype; Humans; Immunoprecipitation; Male; Middle Aged; Nicotine; Nicotinic Agonists; Peptide Fragments; Postmortem Changes; Protein Binding; Statistics as Topic; Thiazoles; Tritium | 2012 |
Investigation of matrix metalloproteinases, MMP-2 and MMP-9, in plasma reveals a decrease of MMP-2 in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Cognitive Dysfunction; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neuropsychological Tests; Thiazoles | 2011 |
Early detection of Alzheimer disease: ¹¹C-PiB PET in twins discordant for cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Brain Mapping; Cognition Disorders; Cross-Sectional Studies; Diseases in Twins; Early Diagnosis; Female; Finland; Humans; Magnetic Resonance Imaging; Male; Positron-Emission Tomography; Thiazoles | 2011 |
Precuneus amyloid burden is associated with reduced cholinergic activity in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Case-Control Studies; Choline O-Acetyltransferase; Female; Humans; Male; Neurofibrillary Tangles; Parietal Lobe; Peptide Fragments; Postmortem Changes; Psychiatric Status Rating Scales; Radioligand Assay; Radionuclide Imaging; Thiazoles; Tritium | 2011 |
Cerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Benzothiazoles; Brain; Brain Mapping; Carbon Radioisotopes; Cerebral Hemorrhage; Cognition Disorders; Female; Humans; Logistic Models; Magnetic Resonance Imaging; Male; Nerve Fibers, Myelinated; Positron-Emission Tomography; Psychiatric Status Rating Scales; Thiazoles | 2011 |
Amyloid β-induced ER stress is enhanced under mitochondrial dysfunction conditions.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Blood Platelets; Brefeldin A; Caspase 3; Cell Death; Cell Fusion; Cell Line, Tumor; Endoplasmic Reticulum; Endoplasmic Reticulum Chaperone BiP; Female; Gene Expression Regulation; Heat-Shock Proteins; Humans; Hybrid Cells; In Situ Nick-End Labeling; Male; Middle Aged; Mitochondria; Peptide Fragments; Poly(ADP-ribose) Polymerases; Protein Synthesis Inhibitors; Tetrazolium Salts; Thapsigargin; Thiazoles | 2012 |
Similar amyloid-β burden in posterior cortical atrophy and Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Benzothiazoles; Brain Mapping; Cerebral Cortex; Enzyme-Linked Immunosorbent Assay; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; tau Proteins; Thiazoles; Ultrasonography | 2011 |
D-Ser-containing humanin shows promotion of fibril formation.
Topics: Alzheimer Disease; Amino Acid Sequence; Benzothiazoles; Circular Dichroism; Congo Red; Humans; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Neuroprotective Agents; Protein Structure, Secondary; Solutions; Stereoisomerism; Structure-Activity Relationship; Thiazoles | 2012 |
Amyloid imaging: liberal or conservative? Let the data decide.
Topics: Alzheimer Disease; Aniline Compounds; Benzothiazoles; Cerebral Cortex; Cognitive Dysfunction; Dementia; Ethylene Glycols; Female; Fluorine Radioisotopes; Humans; Male; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2011 |
Pittsburgh compound B-negative dementia: a possibility of misdiagnosis of patients with non-alzheimer disease-type dementia as having AD.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Dementia; Diagnostic Errors; Female; Humans; Male; Neuropsychological Tests; Peptide Fragments; Positron-Emission Tomography; tau Proteins; Thiazoles | 2011 |
Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; Astrocytes; Benzothiazoles; Disease Models, Animal; Hippocampus; Humans; Mice; Mice, Transgenic; Microglia; Neuroglia; Plaque, Amyloid; Protein Processing, Post-Translational; Receptors, LDL; Thiazoles | 2011 |
Targeting vascular amyloid in arterioles of Alzheimer disease transgenic mice with amyloid β protein antibody-coated nanoparticles.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Arterioles; Benzothiazoles; Disease Models, Animal; Ferric Compounds; Humans; Immunoglobulin G; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Nanoparticles; Peptide Fragments; Plaque, Amyloid; Platelet Endothelial Cell Adhesion Molecule-1; Thiazoles | 2011 |
Instrumental activities of daily living impairment is associated with increased amyloid burden.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloidosis; Aniline Compounds; Body Burden; Data Interpretation, Statistical; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Regression Analysis; Surveys and Questionnaires; Temporal Lobe; Thiazoles | 2011 |
Ligand polarizability contributes to tau fibril binding affinity.
Topics: Alzheimer Disease; Benzothiazoles; Binding Sites; Humans; Indoles; Ligands; Oxindoles; Phenothiazines; Protein Binding; tau Proteins; Thiazoles | 2011 |
Clinical course of patients with familial early-onset Alzheimer's disease potentially lacking senile plaques bearing the E693Δ mutation in amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Apolipoproteins E; Atrophy; Benzothiazoles; Brain; Cerebellar Ataxia; Cognition; Disease Progression; Female; Fluorodeoxyglucose F18; Gait Disorders, Neurologic; Humans; Magnetic Resonance Imaging; Memory Disorders; Middle Aged; Mutation; Neuropsychological Tests; Pedigree; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2011 |
In vivo imaging of astrocytosis in Alzheimer's disease: an ¹¹C-L-deuteriodeprenyl and PIB PET study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain; Carbon Radioisotopes; Deuterium; Female; Gliosis; Humans; Positron-Emission Tomography; Radiopharmaceuticals; Selegiline; Thiazoles; Tissue Distribution | 2011 |
Synthesis and evaluation of ferrocenoyl pentapeptide (Fc-KLVFF) as an inhibitor of Alzheimer's Aβ₁-₄₂ fibril formation in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Drug Design; Drug Evaluation, Preclinical; Electrochemical Techniques; Ferric Compounds; Microscopy, Atomic Force; Microscopy, Electron, Transmission; Molecular Targeted Therapy; Nootropic Agents; Oligopeptides; Oxidation-Reduction; Peptide Fragments; Peptides; Solubility; Thiazoles | 2011 |
Serotonin signaling is associated with lower amyloid-β levels and plaques in transgenic mice and humans.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Antidepressive Agents, Second-Generation; Brain; Citalopram; Female; Humans; Male; Mice; Mice, Transgenic; Positron-Emission Tomography; Radiography; Serotonin; Signal Transduction; Thiazoles; Time Factors | 2011 |
Not quite PIB-positive, not quite PIB-negative: slight PIB elevations in elderly normal control subjects are biologically relevant.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; Tissue Distribution; Young Adult | 2012 |
Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloidosis; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Cohort Studies; Databases, Factual; Female; Gene Expression Profiling; Genotype; Humans; Male; Phenotype; Polymorphism, Single Nucleotide; Positron-Emission Tomography; Risk Factors; Thiazoles | 2012 |
Brain amyloid imaging.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Cognitive Dysfunction; Education, Medical; Fluorine Radioisotopes; Humans; Image Interpretation, Computer-Assisted; Ligands; Molecular Imaging; Nuclear Medicine; Positron-Emission Tomography; Radiopharmaceuticals; Sensitivity and Specificity; Thiazoles | 2011 |
[Current amyloid imaging].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Cognitive Dysfunction; Humans; Middle Aged; Positron-Emission Tomography; Thiazoles | 2010 |
Neurosciences.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Brain; Brain Neoplasms; Humans; Nuclear Medicine; Radionuclide Imaging; Radiopharmaceuticals; Societies, Medical; Thiazoles | 2011 |
Amyloid-β and glucose metabolism in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain Mapping; Cohort Studies; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Positron-Emission Tomography; Statistics as Topic; Thiazoles | 2011 |
Self-assembled polymersomes conjugated with lactoferrin as novel drug carrier for brain delivery.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Caspase 3; Coumarins; Cryoelectron Microscopy; Drug Carriers; Lactic Acid; Lactoferrin; Liposomes; Male; Mice; Mice, Inbred BALB C; Particle Size; Peptides; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Surface Properties; Thiazoles; Tissue Distribution | 2012 |
Role of family history for Alzheimer biomarker abnormalities in the adult children study.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Attention; Biomarkers; Brain; Carbon Radioisotopes; Cognition Disorders; Cohort Studies; Disease Progression; Family Health; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Peptide Fragments; Positron-Emission Tomography; Psychiatric Status Rating Scales; Reaction Time; Residence Characteristics; Statistics as Topic; Thiazoles | 2011 |
Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Anti-Bacterial Agents; Benzothiazoles; Caspase 3; Cell Line, Tumor; Disease Models, Animal; Doxycycline; Drosophila melanogaster; Fluorescent Dyes; Humans; Longevity; Thiazoles | 2011 |
Multimodality imaging characteristics of dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain Mapping; Case-Control Studies; Female; Fluorodeoxyglucose F18; Humans; Imaging, Three-Dimensional; Lewy Body Disease; Magnetic Resonance Imaging; Male; Middle Aged; Occipital Lobe; Positron-Emission Tomography; ROC Curve; Statistics, Nonparametric; Thiazoles | 2012 |
Sensory network dysfunction, behavioral impairments, and their reversibility in an Alzheimer's β-amyloidosis mouse model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Animals; Behavioral Symptoms; Benzoates; Benzothiazoles; Benzylamines; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Enzyme-Linked Immunosorbent Assay; Fourier Analysis; Habituation, Psychophysiologic; Humans; Mice; Mice, Transgenic; Odorants; Olfactory Pathways; Sensation Disorders; Smell; Thiazoles | 2011 |
A novel small Odorranalectin-bearing cubosomes: preparation, brain delivery and pharmacodynamic study on amyloid-β₂₅₋₃₅-treated rats following intranasal administration.
Topics: Administration, Intranasal; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Coumarins; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Glycine; Intracellular Signaling Peptides and Proteins; Lectins; Maze Learning; Peptide Fragments; Rats; Rats, Sprague-Dawley; Streptavidin; Thiazoles; Tissue Distribution | 2012 |
Alzheimer disease biomarkers are associated with body mass index.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Body Mass Index; Cognitive Dysfunction; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Overweight; Positron-Emission Tomography; tau Proteins; Thiazoles | 2011 |
The use of PIB-PET as a dual pathological and functional biomarker in AD.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Biomarkers; Carbon Radioisotopes; Cognitive Dysfunction; Deoxyglucose; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Parietal Lobe; Positron-Emission Tomography; Regional Blood Flow; Thiazoles | 2012 |
Amyloid-β oligomers stimulate microglia through a tyrosine kinase dependent mechanism.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cells, Cultured; Dasatinib; Female; Humans; Male; Mice; Mice, Inbred C57BL; Microglia; Phosphotyrosine; Plaque, Amyloid; Polymers; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Pyrimidines; Thiazoles; Tumor Necrosis Factor-alpha | 2012 |
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Topics: Acetylcholinesterase; Alzheimer Disease; Azo Compounds; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Indoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Conformation; Piperidines; Spiro Compounds; Structure-Activity Relationship; Temperature; Thiazoles; Thiosemicarbazones; Triazoles | 2012 |
Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Cognition; Early Diagnosis; Humans; Longitudinal Studies; Male; Middle Aged; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2011 |
The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Animals; Apoptosis; Aspartic Acid Endopeptidases; Blotting, Western; Brain; Cell Death; Coloring Agents; Fluorescent Antibody Technique; Gene Expression Regulation; In Situ Nick-End Labeling; MicroRNAs; Necrosis; PC12 Cells; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Tetrazolium Salts; Thiazoles; Transfection | 2012 |
Lack of association between prior depressive episodes and cerebral [11C]PiB binding.
Topics: Age of Onset; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Antidepressive Agents; Cerebrum; Depression; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Risk Factors; Severity of Illness Index; Thiazoles | 2012 |
Promotion of β-amyloid production by C-reactive protein and its implications in the early pathogenesis of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Blotting, Western; C-Reactive Protein; Coloring Agents; Complement C1; Enzyme-Linked Immunosorbent Assay; L-Lactate Dehydrogenase; Mice; Mice, Inbred C57BL; Mice, Transgenic; PC12 Cells; Presenilin-1; Presenilin-2; Rats; Real-Time Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Tumor Necrosis Factor-alpha | 2012 |
Evidence for astrocytosis in prodromal Alzheimer disease provided by 11C-deuterium-L-deprenyl: a multitracer PET paradigm combining 11C-Pittsburgh compound B and 18F-FDG.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Case-Control Studies; Cognitive Dysfunction; Deuterium; Female; Fluorodeoxyglucose F18; Gliosis; Humans; Male; Middle Aged; Monoamine Oxidase; Neuropsychological Tests; Positron-Emission Tomography; Radioactive Tracers; Retrospective Studies; Selegiline; Thiazoles | 2012 |
11C-PiB imaging of human immunodeficiency virus-associated neurocognitive disorder.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Benzothiazoles; Case-Control Studies; Cerebral Cortex; Cognition Disorders; Female; HIV Infections; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Peptide Fragments; Positron-Emission Tomography; Thiazoles | 2012 |
Quantitative EEG and LORETA: valuable tools in discerning FTD from AD?
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Diagnosis, Differential; Electroencephalography; Female; Frontotemporal Dementia; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Multimodal Imaging; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tomography, X-Ray Computed | 2012 |
Differential diagnosis in Alzheimer's disease and dementia with Lewy bodies via VMAT2 and amyloid imaging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Aniline Compounds; Brain Mapping; Carbon Radioisotopes; Case-Control Studies; Corpus Striatum; Diagnosis, Differential; Female; Fluorine Radioisotopes; Humans; Lewy Body Disease; Male; Middle Aged; Positron-Emission Tomography; Tetrabenazine; Thiazoles; Vesicular Monoamine Transport Proteins | 2012 |
Toward a multifactorial model of Alzheimer disease.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Biomarkers; Brain; Cognition; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Models, Neurological; Organ Size; Peptide Fragments; Positron-Emission Tomography; tau Proteins; Thiazoles | 2012 |
Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Humans; Male; Neurofibrillary Tangles; Plaque, Amyloid; Radionuclide Imaging; Thiazoles | 2012 |
Association of lifetime cognitive engagement and low β-amyloid deposition.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Brain Mapping; Cognition Disorders; Female; Humans; Linear Models; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Positron-Emission Tomography; Retrospective Studies; Thiazoles; Young Adult | 2012 |
Selectivity requirements for diagnostic imaging of neurofibrillary lesions in Alzheimer's disease: a simulation study.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Computer Simulation; Humans; Image Interpretation, Computer-Assisted; Male; Models, Neurological; Neurofibrillary Tangles; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles | 2012 |
Can target-to-pons ratio be used as a reliable method for the analysis of [11C]PIB brain scans?
Topics: Alzheimer Disease; Aniline Compounds; Benzothiazoles; Cerebellum; Female; Fiducial Markers; Humans; Male; Middle Aged; Pons; Positron-Emission Tomography; Radiopharmaceuticals; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Thiazoles; United Kingdom | 2012 |
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation.
Topics: Acetylglucosamine; Adaptor Proteins, Signal Transducing; Alzheimer Disease; Animals; Carbohydrate Conformation; Disease Models, Animal; Enzyme Inhibitors; Female; Humans; Mice; Mice, Transgenic; N-Acetylglucosaminyltransferases; Neurodegenerative Diseases; Neurons; Phosphorylation; Pyrans; tau Proteins; Thiazoles | 2012 |
Using graphene oxide high near-infrared absorbance for photothermal treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Cell Survival; Graphite; Humans; Hyperthermia, Induced; Mice; Nanostructures; Oxides; PC12 Cells; Phototherapy; Rats; Thiazoles | 2012 |
Shapes of the trajectories of 5 major biomarkers of Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Aniline Compounds; Apolipoprotein E4; Biomarkers; Cognition Disorders; Cohort Studies; Cross-Sectional Studies; Female; Fluorodeoxyglucose F18; Hippocampus; Humans; Immunoassay; Magnetic Resonance Imaging; Male; Mental Status Schedule; Nonlinear Dynamics; Peptide Fragments; Positron-Emission Tomography; tau Proteins; Thiazoles | 2012 |
White matter hyperintensities predict amyloid increase in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Apolipoprotein E4; Brain; Brain Mapping; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Fibers, Myelinated; Neuropsychological Tests; Positron-Emission Tomography; Predictive Value of Tests; Psychiatric Status Rating Scales; Thiazoles | 2012 |
A multifunctional peptide rescues memory deficits in Alzheimer's disease transgenic mice by inhibiting Aβ42-induced cytotoxicity and increasing microglial phagocytosis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Calcium; Cell Line, Tumor; Cell Survival; Cloning, Molecular; Coloring Agents; DNA; Enzyme-Linked Immunosorbent Assay; Humans; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Microglia; Nitric Oxide; Peptide Fragments; Peptide Library; Peptides; Phagocytosis; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2012 |
Small-animal PET imaging of amyloid-beta plaques with [11C]PiB and its multi-modal validation in an APP/PS1 mouse model of Alzheimer's disease.
Topics: Age Factors; Alzheimer Disease; Aniline Compounds; Animals; Benzothiazoles; Enzyme-Linked Immunosorbent Assay; Mice; Mice, Mutant Strains; Microscopy, Fluorescence; Plaque, Amyloid; Positron-Emission Tomography; Radioligand Assay; Thiazoles; Translational Research, Biomedical | 2012 |
Naphthoquinone-tyrptophan reduces neurotoxic Aβ*56 levels and improves cognition in Alzheimer's disease animal model.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Benzothiazoles; Blood-Brain Barrier; Brain Chemistry; Cognition; Drosophila; Fluorescent Dyes; Humans; Longevity; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Models, Molecular; Motor Activity; Naphthalenes; Neurofibrils; Neuroprotective Agents; Psychomotor Performance; Recognition, Psychology; Thiazoles; Tryptophan | 2012 |
An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Biomarkers; Brain; Cognition Disorders; Disease Progression; Female; Fluorodeoxyglucose F18; Humans; Longitudinal Studies; Male; Mental Status Schedule; National Institute on Aging (U.S.); Neuropsychological Tests; Positron-Emission Tomography; Thiazoles; United States | 2012 |
Amyloid and metabolic positron emission tomography imaging of cognitively normal adults with Alzheimer's parents.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Brain Mapping; Cognition Disorders; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Sensitivity and Specificity; Thiazoles | 2013 |
Binding of the three-repeat domain of tau to phospholipid membranes induces an aggregated-like state of the protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Benzothiazoles; Biophysics; Circular Dichroism; Humans; Lipid Bilayers; Lipids; Liposomes; Lysine; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Phosphatidylcholines; Phosphatidylserines; Phospholipids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity; tau Proteins; Thiazoles; Unilamellar Liposomes | 2012 |
Identification and characterization of an aβ oligomer precipitating peptide that may be useful to explore gene therapeutic approaches to Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Line, Tumor; Centrifugation, Density Gradient; Disease Models, Animal; Genetic Therapy; Humans; Mice; Nephelometry and Turbidimetry; Neurons; Peptides; Sequence Analysis, DNA; Thiazoles | 2012 |
Short-term clinical outcomes for stages of NIA-AA preclinical Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Chi-Square Distribution; Cognition Disorders; Disease Progression; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; National Institute on Aging (U.S.); Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Thiazoles; United States | 2012 |
Amyloid burden and metabolic function in early-onset Alzheimer's disease: parietal lobe involvement.
Topics: Age of Onset; Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Apolipoproteins E; Brain Mapping; Carbon Radioisotopes; Case-Control Studies; Cognition Disorders; Female; Fluorodeoxyglucose F18; Genotype; Glucose; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Parietal Lobe; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2012 |
The influence of spin-labeled fluorene compounds on the assembly and toxicity of the aβ peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Blotting, Western; Cell Line, Tumor; Circular Dichroism; Electron Spin Resonance Spectroscopy; Fluorenes; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; Microscopy, Atomic Force; Models, Biological; Molecular Structure; Nitrogen Oxides; Spin Labels; Tetrazolium Salts; Thiazoles | 2012 |
Inhibitory effect of curcumin on the Al(III)-induced Aβ₄₂ aggregation and neurotoxicity in vitro.
Topics: Aluminum; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Curcumin; Microscopy, Atomic Force; Neurotoxicity Syndromes; PC12 Cells; Peptide Fragments; Rats; Thiazoles | 2012 |
Regional dynamics of amyloid-β deposition in healthy elderly, mild cognitive impairment and Alzheimer's disease: a voxelwise PiB-PET longitudinal study.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain Mapping; Carbon Radioisotopes; Case-Control Studies; Cognitive Dysfunction; Disease Progression; Female; Humans; Longitudinal Studies; Male; Neocortex; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2012 |
Maternal family history is associated with Alzheimer's disease biomarkers.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Cognitive Dysfunction; Cohort Studies; Cross-Sectional Studies; Family Health; Female; Humans; Male; Middle Aged; Mothers; Positron-Emission Tomography; Thiazoles | 2012 |
Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Cell Line; Cell Line, Transformed; Cells, Cultured; Dasatinib; Disease Models, Animal; Enzyme Activation; Longitudinal Studies; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Peptide Fragments; Protein Kinase Inhibitors; Pyrimidines; src-Family Kinases; Thiazoles | 2012 |
Brain accumulation of amyloid β protein visualized by positron emission tomography and BF-227 in Alzheimer's disease patients with or without diabetes mellitus.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzoxazoles; Brain; Case-Control Studies; Diabetes Complications; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2013 |
PEGylated nanoparticles bind to and alter amyloid-beta peptide conformation: toward engineering of functional nanomedicines for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Bioengineering; Complement Activation; Electrophoresis, Capillary; Humans; In Vitro Techniques; Models, Molecular; Molecular Dynamics Simulation; Nanomedicine; Nanoparticles; Nanotechnology; Peptide Fragments; Polyethylene Glycols; Protein Binding; Protein Conformation; Surface Plasmon Resonance; Thiazoles | 2012 |
The exception makes the rule: not all Aβ plaques are created equal.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Female; Humans; Male; Mutation; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2012 |
Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Biomarkers; Carbon Radioisotopes; Cognition; Female; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Mutation; Neuropsychological Tests; Peptide Fragments; Presenilin-1; Radionuclide Imaging; Radiopharmaceuticals; tau Proteins; Thiazoles | 2012 |
Parietal variant Alzheimer's disease presenting with dyscalculia.
Topics: Alzheimer Disease; Aniline Compounds; Dyscalculia; Female; Fluorodeoxyglucose F18; Hippocampus; Humans; Magnetic Resonance Imaging; Middle Aged; Positron-Emission Tomography; Thiazoles | 2013 |
Nonfluent/agrammatic PPA with in-vivo cortical amyloidosis and Pick's disease pathology.
Topics: Aged; Alzheimer Disease; Amyloidosis; Aniline Compounds; Carbon Radioisotopes; Disease Progression; Female; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Frontal Lobe; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Neuropsychological Tests; Pick Disease of the Brain; Positron-Emission Tomography; Primary Progressive Nonfluent Aphasia; Thiazoles | 2013 |
The butter flavorant, diacetyl, exacerbates β-amyloid cytotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Blood-Brain Barrier; Butter; Cell Line; Cell Survival; Circular Dichroism; Diacetyl; Dogs; Flavoring Agents; Fluorescent Dyes; Humans; Lactoylglutathione Lyase; Madin Darby Canine Kidney Cells; Peptide Fragments; Permeability; Protein Conformation; Thiazoles | 2012 |
4-Hydroxyhexenal (HHE) impairs glutamate transport in astrocyte cultures.
Topics: Aged, 80 and over; Aldehydes; Alzheimer Disease; Animals; Astrocytes; Biological Transport, Active; Blotting, Western; Brain Chemistry; Cells, Cultured; Cognitive Dysfunction; Coloring Agents; Excitatory Amino Acid Transporter 2; Female; Glutamate Plasma Membrane Transport Proteins; Glutamates; Humans; Immunoprecipitation; Lipid Peroxidation; Male; Parahippocampal Gyrus; Rats; Tetrazolium Salts; Thiazoles | 2012 |
Postmortem Pittsburgh Compound B (PiB) binding increases with Alzheimer's disease progression.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Brain; Cognitive Dysfunction; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Frontotemporal Dementia; Humans; Male; Neuropsychological Tests; Organ Size; Positron-Emission Tomography; Thiazoles | 2012 |
Rhodanine and thiohydantoin derivatives for detecting tau pathology in Alzheimer's brains.
Topics: Alzheimer Disease; Animals; Autoradiography; Benzothiazoles; Brain; Humans; Iodine Radioisotopes; Mice; Neurofibrillary Tangles; Positron-Emission Tomography; Radiopharmaceuticals; Recombinant Proteins; Rhodanine; Tauopathies; Thiazoles; Thiohydantoins; Tissue Distribution | 2011 |
Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Avoidance Learning; Biological Availability; Brain; Click Chemistry; Cognition Disorders; Glucose; Hippocampus; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Mimicry; Mutation; Neurons; Neuroprotective Agents; Nitric Oxide; Oxygen; Primary Cell Culture; Prodrugs; Receptors, GABA-A; Small Molecule Libraries; Structure-Activity Relationship; Synaptic Transmission; Thiazoles; Tissue Distribution | 2012 |
[Amyloid imaging with 11C-PiB].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Carbon Radioisotopes; Humans; Radiopharmaceuticals; Thiazoles | 2011 |
[In vivo amyloid imaging using BF-227].
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzoxazoles; Cerebral Cortex; Humans; Positron-Emission Tomography; Thiazoles | 2011 |
Amyloid imaging in Alzheimer's disease: comparison of florbetapir and Pittsburgh compound-B positron emission tomography.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Brain; Case-Control Studies; Ethylene Glycols; Female; Humans; Male; Neuroimaging; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2012 |
Pharmacokinetics of [¹⁸F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Disease Models, Animal; Fluorine Radioisotopes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Thiazoles; Tissue Distribution | 2012 |
[Multi-center study of inter-scanner difference in brain positron emission tomography].
Topics: Alzheimer Disease; Aniline Compounds; Brain; Fluorodeoxyglucose F18; Humans; Phantoms, Imaging; Positron-Emission Tomography; Quality Control; Radiopharmaceuticals; Thiazoles | 2012 |
[Synthesis of benzothiazole derivatives and their binding characteristics with beta-amyloid].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Humans; Peptide Fragments; Protein Binding; Schiff Bases; Surface Plasmon Resonance; Thiazoles | 2012 |
Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Catalytic Domain; Cell Line, Tumor; Crystallography, X-Ray; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Pyrazoles; Quinazolines; Structure-Activity Relationship; Thiazoles | 2012 |
Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Benzothiazoles; Female; Humans; Male; Neurofibrillary Tangles; Neuroimaging; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2012 |
Cognitive decline and amyloid accumulation in patients with mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Caudate Nucleus; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Progression; Female; Follow-Up Studies; Humans; Longitudinal Studies; Male; Neuropsychological Tests; Positron-Emission Tomography; Psychometrics; Radiopharmaceuticals; Temporal Lobe; Thiazoles | 2012 |
Interaction between amyloid-β pathology and cortical functional columnar organization.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Electron Transport Complex IV; Humans; Mice; Mice, Transgenic; Models, Neurological; Mutation; Neural Pathways; Plaque, Amyloid; Presenilin-1; Somatosensory Cortex; Thiazoles | 2012 |
Quantitative longitudinal interrelationships between brain metabolism and amyloid deposition during a 2-year follow-up in patients with early Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Case-Control Studies; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2012 |
Subjective cognitive complaints and amyloid burden in cognitively normal older individuals.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Female; Humans; Male; Neuropsychological Tests; Positron-Emission Tomography; Prodromal Symptoms; Radiopharmaceuticals; Thiazoles | 2012 |
Clinical features of Pittsburgh compound-B-negative dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Case-Control Studies; Dementia; Female; Fluorodeoxyglucose F18; Humans; Iodine Radioisotopes; Lewy Body Disease; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Perfusion Imaging; Positron-Emission Tomography; Radiopharmaceuticals; tau Proteins; Thiazoles | 2012 |
A European multicentre PET study of fibrillar amyloid in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Apolipoproteins E; Brain; Brain Chemistry; Case-Control Studies; Europe; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2013 |
In situ monitoring Alzheimer's disease β-amyloid aggregation and screening of Aβ inhibitors using a perylene probe.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cations; DNA, Single-Stranded; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Humans; Kinetics; Microscopy, Atomic Force; Models, Chemical; Peptide Fragments; Perylene; Protein Binding; Spectrophotometry, Ultraviolet; Surface Plasmon Resonance; Thiazoles | 2013 |
Binary classification of ¹⁸F-flutemetamol PET using machine learning: comparison with visual reads and structural MRI.
Topics: Aged; Algorithms; Alzheimer Disease; Aniline Compounds; Artificial Intelligence; Benzothiazoles; Cognitive Dysfunction; Diagnosis, Differential; Female; Fluorine Radioisotopes; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Observer Variation; Pattern Recognition, Automated; Positron-Emission Tomography; Reproducibility of Results; Sensitivity and Specificity; Thiazoles | 2013 |
A novel inhibitor of amyloid β (Aβ) peptide aggregation: from high throughput screening to efficacy in an animal model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Benzothiazoles; Chemistry, Pharmaceutical; Drosophila melanogaster; Drug Design; Drug Evaluation, Preclinical; Green Fluorescent Proteins; Humans; Indoles; Models, Chemical; Peptide Fragments; Peptides; Reactive Oxygen Species; Thiazoles | 2012 |
Molecular plasticity regulates oligomerization and cytotoxicity of the multipeptide-length amyloid-β peptide pool.
Topics: Alzheimer Disease; Amino Acid Motifs; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Cell Survival; Fluorescent Dyes; Humans; Kinetics; Microscopy, Atomic Force; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Thiazoles | 2012 |
Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blotting, Western; Cell Survival; Cells, Cultured; Chromans; Congo Red; Female; Free Radical Scavengers; Mutation; Neurons; Neurotoxins; Oxidative Stress; Peptide Fragments; Pregnancy; Protein Conformation; Rats; Rats, Wistar; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Vitamin E | 2012 |
The N-methylated peptide SEN304 powerfully inhibits Aβ(1-42) toxicity by perturbing oligomer formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Humans; Long-Term Potentiation; Male; Mice; Neurons; Oligopeptides; Peptide Fragments; Protein Multimerization; Protein Structure, Quaternary; Rats; Surface Plasmon Resonance; Thiazoles; Tumor Cells, Cultured | 2012 |
Plasma based markers of [11C] PiB-PET brain amyloid burden.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Biomarkers; Brain; Cluster Analysis; Female; Genotype; Humans; Male; Metabolome; Metabolomics; Middle Aged; Positron-Emission Tomography; Prognosis; Reproducibility of Results; Thiazoles | 2012 |
Apraxia of speech and phonological errors in the diagnosis of nonfluent/agrammatic and logopenic variants of primary progressive aphasia.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Aphasia, Broca; Apraxias; Carbon Radioisotopes; Diagnosis, Differential; Female; Frontotemporal Dementia; Humans; Male; Middle Aged; Phonation; Phonetics; Positron-Emission Tomography; Primary Progressive Nonfluent Aphasia; Psycholinguistics; Thiazoles | 2012 |
The usefulness of amyloid imaging in predicting the clinical outcome after two years in subjects with mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Apolipoprotein E4; Benzothiazoles; Cognitive Dysfunction; Dementia; Disease Progression; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Outcome Assessment, Health Care; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles | 2013 |
Structure-based design and synthesis of benzothiazole phosphonate analogues with inhibitors of human ABAD-Aβ for treatment of Alzheimer's disease.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Alzheimer Disease; Animals; Binding Sites; Caco-2 Cells; Drug Design; Humans; Ligands; Mice; Molecular Docking Simulation; Organophosphonates; Quantitative Structure-Activity Relationship; Thiazoles | 2013 |
Monoclonal antibodies against large oval aggregates of Aβ1-42.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Antibody Specificity; Benzothiazoles; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Humans; Mice; Microscopy, Atomic Force; Peptide Fragments; Protein Structure, Secondary; Thiazoles | 2013 |
Modulation of α7 nicotinic acetylcholine receptor and fibrillar amyloid-β interactions in Alzheimer's disease brain.
Topics: Aged; Aged, 80 and over; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Cell Membrane; Cholinergic Agents; Dose-Response Relationship, Drug; Drug Interactions; Frontal Lobe; Humans; Male; Middle Aged; Postmortem Changes; Protein Binding; Receptors, Nicotinic; Thiazoles; Tritium | 2013 |
Associations between gonadotropins, testosterone and β amyloid in men at risk of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Cognitive Dysfunction; Cohort Studies; Gonadotropins; Humans; Linear Models; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Peptide Fragments; Positron-Emission Tomography; Psychiatric Status Rating Scales; Risk Factors; Statistics, Nonparametric; Testosterone; Thiazoles | 2014 |
Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Blood Pressure; Cardiovascular Diseases; Cross-Sectional Studies; Female; Humans; Hydrocortisone; Male; Positron-Emission Tomography; Radiopharmaceuticals; Risk Factors; Thiazoles | 2012 |
Pittsburgh compound B and the postmortem diagnosis of Alzheimer disease.
Topics: Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Biomarkers; Brain; Brain Chemistry; Female; Humans; Male; Neurofibrillary Tangles; Neuropsychological Tests; Plaque, Amyloid; Predictive Value of Tests; Radionuclide Imaging; Radiopharmaceuticals; Sodium Dodecyl Sulfate; Solubility; Surface-Active Agents; Thiazoles | 2012 |
A peptide binding to the β-site of APP improves spatial memory and attenuates Aβ burden in Alzheimer's disease transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Benzothiazoles; Cell Line, Tumor; Enzyme-Linked Immunosorbent Assay; Humans; Maze Learning; Memory; Mice; Mice, Transgenic; Microscopy, Electron, Transmission; Peptide Library; Peptides; Protein Binding; Protein Structure, Tertiary; Sequence Analysis, DNA; Spatial Behavior; Tetrazolium Salts; Thiazoles | 2012 |
Synthesis and structure-activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Dose-Response Relationship, Drug; Humans; Molecular Structure; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Structure-Activity Relationship; Thiazoles | 2012 |
Plasma acetylcholinesterase activity correlates with intracerebral β-amyloid load.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Brain Mapping; Butyrylcholinesterase; Carbon Radioisotopes; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Psychiatric Status Rating Scales; Radiopharmaceuticals; Thiazoles | 2013 |
Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Ceruloplasmin; Cognition Disorders; Copper; Female; Humans; Linear Models; Longitudinal Studies; Male; Mass Spectrometry; Middle Aged; Positron-Emission Tomography; Psychiatric Status Rating Scales; Thiazoles | 2013 |
β-Amyloid in Lewy body disease is related to Alzheimer's disease-like atrophy.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Aniline Compounds; Atrophy; Benzothiazoles; Dementia; Female; Humans; Image Processing, Computer-Assisted; Lewy Body Disease; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2013 |
Amyloid and its association with default network integrity in Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Cognitive Dysfunction; Female; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net; Positron-Emission Tomography; Thiazoles | 2014 |
Amyloid-β(1-42) protofibrils formed in modified artificial cerebrospinal fluid bind and activate microglia.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Cerebrospinal Fluid; Chromatography, Gel; Culture Media; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Macrophage Activation; Mice; Microglia; Microscopy, Electron; Peptide Fragments; Quinolines; Thiazoles; Tumor Necrosis Factor-alpha | 2013 |
Differential effect of APOE genotype on amyloid load and glucose metabolism in AD dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloidosis; Aniline Compounds; Apolipoproteins E; Benzothiazoles; Blood Glucose; Cerebral Cortex; Female; Fluorodeoxyglucose F18; Genotype; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Severity of Illness Index; Thiazoles | 2013 |
Comparison of MRI based and PET template based approaches in the quantitative analysis of amyloid imaging with PIB-PET.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Carbon Radioisotopes; Cognitive Dysfunction; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2013 |
Surface plasmon resonance imaging of amyloid-β aggregation kinetics in the presence of epigallocatechin gallate and metals.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Catechin; Copper; Ferric Compounds; Humans; Ions; Kinetics; Metals; Microscopy, Electron, Transmission; Peptide Fragments; Surface Plasmon Resonance; Thiazoles; Zinc | 2013 |
MR-less surface-based amyloid estimation by subject-specific atlas selection and Bayesian fusion.
Topics: Algorithms; Alzheimer Disease; Amyloidogenic Proteins; Aniline Compounds; Bayes Theorem; Benzothiazoles; Brain; Female; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Magnetic Resonance Imaging; Male; Pattern Recognition, Automated; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Subtraction Technique; Thiazoles | 2012 |
Low background and high contrast PET imaging of amyloid-β with [11C]AZD2995 and [11C]AZD2184 in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aminopyridines; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Benzoxazoles; Binding Sites; Brain; Carbon Radioisotopes; Case-Control Studies; Female; Humans; Magnetic Resonance Imaging; Male; Mice; Mice, Transgenic; Middle Aged; Positron-Emission Tomography; Protein Binding; Radioligand Assay; Radiopharmaceuticals; Sensitivity and Specificity; Thiazoles | 2013 |
Simultaneous measurement of amyloid fibril formation by dynamic light scattering and fluorescence reveals complex aggregation kinetics.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescence; Humans; Huntington Disease; Kinetics; Light; Parkinson Disease; Particle Size; Protein Structure, Secondary; Thiazoles | 2013 |
An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloidogenic Proteins; Animals; Benzothiazoles; Caenorhabditis elegans; Hippocampus; Mice; Mice, Inbred C57BL; Models, Biological; Neurodegenerative Diseases; Neurons; Peptides; Prions; Protein Binding; Protein Structure, Tertiary; Surface Plasmon Resonance; Synapses; Thiazoles | 2013 |
Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Coordination Complexes; Copper; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Platinum; Spectrometry, Fluorescence; Thiazoles; Zinc | 2013 |
Generation of reactive oxygen species and activation of NF-kappaB by non-Abeta component of Alzheimer's disease amyloid.
Topics: Active Transport, Cell Nucleus; Alzheimer Disease; Amyloid; Animals; Antioxidants; Apoptosis; Astrocytes; Cells, Cultured; DNA; Gene Expression; Humans; L-Lactate Dehydrogenase; Mitochondria; Nerve Tissue Proteins; Neurons; NF-kappa B; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Reactive Oxygen Species; Synucleins; Tetrazolium Salts; Thiazoles | 2002 |
Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Clusterin; Disease Models, Animal; Glycoproteins; Mice; Mice, Knockout; Molecular Chaperones; Neurites; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2002 |
New class of inhibitors of amyloid-beta fibril formation. Implications for the mechanism of pathogenesis in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Apomorphine; Benzothiazoles; Fluorescent Dyes; Humans; Hydroxylation; Kinetics; Microscopy, Electron; Models, Biological; Protein Structure, Quaternary; Thiazoles | 2002 |
Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.
Topics: Administration, Topical; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Immunotherapy; Mice; Mice, Transgenic; Microscopy, Fluorescence; Mutation; Phagocytosis; Plaque, Amyloid; Thiazoles | 2002 |
Beta-amyloid plaques in a model for sporadic Alzheimer's disease based on transgenic anti-nerve growth factor antibodies.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Autoantibodies; Benzothiazoles; Brain; Cerebellum; Disease Models, Animal; Locus Coeruleus; Mice; Mice, Transgenic; Neostriatum; Nerve Growth Factor; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; Signal Transduction; Silver Staining; Thiazoles | 2002 |
Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Disease Models, Animal; Female; Humans; Male; Membrane Proteins; Mice; Mice, Transgenic; Neurotoxins; Plaque, Amyloid; Presenilin-1; Thiazoles | 2002 |
The effects of the total saponin of Dipsacus asperoides on the damage of cultured neurons induced by beta-amyloid protein 25-35.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Brain; Cell Death; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Hippocampus; Hydro-Lyases; Lipid Peroxidation; Malondialdehyde; Neurons; Neuroprotective Agents; Oleanolic Acid; Oxidative Stress; Peptide Fragments; Rats; Saponins; Tetrazolium Salts; Thiazoles | 2002 |
Amyloid fibril formation by a synthetic peptide from a region of human acetylcholinesterase that is homologous to the Alzheimer's amyloid-beta peptide.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Biotinylation; Cell Division; Circular Dichroism; Coloring Agents; Congo Red; Fluorescent Dyes; Humans; Microscopy, Electron; Neurofibrillary Tangles; PC12 Cells; Peptide Fragments; Protein Binding; Rats; Thiazoles | 2002 |
Molecular imaging of amyloid beta peptides in mouse brain sections using mass spectrometry.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Neuropathies, Familial; Animals; Benzothiazoles; Blotting, Western; Brain; Brain Chemistry; Frozen Sections; Humans; Image Processing, Computer-Assisted; Mice; Mice, Transgenic; Molecular Sequence Data; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles; Tissue Distribution | 2002 |
IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autopsy; Autoradiography; Benzothiazoles; Fluorescence; Humans; Mice; Mice, Transgenic; Molecular Probes; Plaque, Amyloid; Pyridines; Thiazoles | 2002 |
Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Binding, Competitive; Blood-Brain Barrier; Brain; Contrast Media; Disease Models, Animal; Gadolinium; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Membrane Proteins; Mice; Mice, Transgenic; Molecular Probe Techniques; Neurons; Peptide Fragments; Plaque, Amyloid; Predictive Value of Tests; Presenilin-1; Putrescine; Reproducibility of Results; Thiazoles | 2002 |
Electron microscopic analysis of nanoparticles delivering thioflavin-T after intrahippocampal injection in mouse: implications for targeting beta-amyloid in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Drug Carriers; Drug Delivery Systems; Enbucrilate; Female; Fluorescent Dyes; Hippocampus; Injections; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Nanotechnology; Particle Size; Polymers; Polystyrenes; Thiazoles | 2003 |
In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Axons; Benzothiazoles; Cerebral Cortex; Dendrites; Dextrans; Disease Models, Animal; Fluorescent Dyes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Neurites; Neuropil; Plaque, Amyloid; Thiazoles | 2003 |
The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Binding, Competitive; Brain Chemistry; Cerebellum; Dementia; Entorhinal Cortex; Fluorescent Dyes; Frontal Lobe; Humans; Ligands; Middle Aged; Neurofibrillary Tangles; Reference Values; Substrate Specificity; Thiazoles; Tritium | 2003 |
In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antioxidants; Benzothiazoles; Cerebral Cortex; Cyclic N-Oxides; Disease Models, Animal; Fluorescent Dyes; Free Radical Scavengers; Free Radicals; Infrared Rays; Lasers; Mice; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Nitrogen Oxides; Oxidation-Reduction; Oxidative Stress; Plaque, Amyloid; Reactive Oxygen Species; Thiazoles | 2003 |
Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Artifacts; Binding, Competitive; Blood-Brain Barrier; Brain; Humans; Immunohistochemistry; Iodine Radioisotopes; Mice; Mice, Transgenic; Nerve Fibers, Myelinated; Peptide Fragments; Plaque, Amyloid; Radionuclide Imaging; Reproducibility of Results; Styrenes; Thiazoles | 2003 |
Direct determination of the proportion of intra- and extra-cellular neocortical neurofibrillary tangles in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Antibody Technique; Humans; Inclusion Bodies; Microtubule-Associated Proteins; Neocortex; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; tau Proteins; Thiazoles | 2003 |
Specific compositions of amyloid-beta peptides as the determinant of toxic beta-aggregation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Dimerization; Genetic Variation; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Peptide Fragments; Static Electricity; Thiazoles | 2003 |
Intracranially administered anti-Abeta antibodies reduce beta-amyloid deposition by mechanisms both independent of and associated with microglial activation.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antibodies; Benzothiazoles; Drug Administration Routes; Frontal Lobe; Hippocampus; Histocompatibility Antigens Class II; Immunization, Passive; Immunohistochemistry; Leukocyte Common Antigens; Membrane Proteins; Mice; Mice, Transgenic; Microglia; Plaque, Amyloid; Presenilin-1; Thiazoles; Time Factors | 2003 |
Anti-inflammatory drug therapy alters beta-amyloid processing and deposition in an animal model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Humans; Ibuprofen; Mice; Mice, Transgenic; Microglia; Peptide Fragments; Pioglitazone; Receptors, Cytoplasmic and Nuclear; Thiazoles; Thiazolidinediones; Transcription Factors | 2003 |
Nitration of tau protein is linked to neurodegeneration in tauopathies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Basal Ganglia; Benzothiazoles; Cell Line; Cerebral Cortex; Down Syndrome; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Nerve Degeneration; Neurodegenerative Diseases; Neurofibrillary Tangles; Nitrates; Pick Disease of the Brain; tau Proteins; Tauopathies; Thiazoles; Tissue Distribution | 2003 |
Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Amyloidosis; Animals; Coloring Agents; Humans; Hydrogen Bonding; Microscopy, Electron; Models, Molecular; Molecular Sequence Data; Mutation; PC12 Cells; Peptide Fragments; Peptides; Protein Conformation; Protein Structure, Secondary; Rats; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Fourier Transform Infrared; Tetrazolium Salts; Thiazoles; Time Factors | 2003 |
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Flavonoids; Humans; Kidney; Kinetics; Microscopy, Electron; Peptide Fragments; Phenols; Polymers; Quercetin; Spectrometry, Fluorescence; Tetrazolium Salts; Thiazoles | 2003 |
Characterization of radioiodinated ligand binding to amyloid beta plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Binding, Competitive; Brain; Humans; Iodine Radioisotopes; Ligands; Male; Mice; Mice, Inbred ICR; Peptide Fragments; Plaque, Amyloid; Pyrazoles; Pyridines; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2003 |
Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives.
Topics: Alzheimer Disease; Animals; Binding Sites; Binding, Competitive; Brain; Female; Iodine Radioisotopes; Membrane Lipids; Mice; Molecular Conformation; Molecular Structure; Plaque, Amyloid; Radionuclide Imaging; Thiazoles | 2003 |
Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Aniline Compounds; Animals; Biological Transport, Active; Blood-Brain Barrier; Brain; Fluorescent Dyes; Humans; Ligands; Mice; Mice, Transgenic; Microscopy, Fluorescence, Multiphoton; Plaque, Amyloid; Protein Binding; Thiazoles; Tomography, Emission-Computed | 2003 |
In vivo labeling of amyloid with BF-108.
Topics: Acridines; Affinity Labels; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Brain; Female; Fluorescent Dyes; Humans; In Vitro Techniques; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Neurofibrillary Tangles; Plaque, Amyloid; Rats; Rats, Wistar; Thiazoles | 2004 |
Effect of different anti-Abeta antibodies on Abeta fibrillogenesis as assessed by atomic force microscopy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antibodies; Benzothiazoles; Fluorescence; Microscopy, Atomic Force; Neurofibrillary Tangles; Peptide Fragments; Plaque, Amyloid; Protein Structure, Quaternary; Software; Thiazoles | 2004 |
Neuronal localization of C1q in preclinical Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biomarkers; Brain; Cerebral Cortex; Complement C1q; Disease Progression; Down Syndrome; Encephalitis; Female; Genetic Predisposition to Disease; Glial Fibrillary Acidic Protein; Gliosis; Hippocampus; Humans; Immunohistochemistry; Middle Aged; Neurons; Peptide Fragments; Plaque, Amyloid; Thiazoles | 2004 |
Evidence for an intermediate in tau filament formation.
Topics: Alzheimer Disease; Anions; Arachidonic Acid; Benzothiazoles; Humans; Hydrophobic and Hydrophilic Interactions; Intermediate Filament Proteins; Micelles; Microspheres; Neurofibrillary Tangles; Neurofilament Proteins; Recombinant Proteins; Spectrometry, Fluorescence; Static Electricity; Surface Properties; Surface-Active Agents; tau Proteins; Thiazoles | 2004 |
The proteomics of positron emission tomography.
Topics: Alzheimer Disease; Aniline Compounds; Humans; Proteomics; Radiopharmaceuticals; Thiazoles; Tomography, Emission-Computed | 2004 |
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Autoradiography; Binding Sites; Brain; Brain Chemistry; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Thiazoles; Time Factors; Tomography, Emission-Computed | 2004 |
Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anti-Inflammatory Agents, Non-Steroidal; Benzothiazoles; Cinnamates; Curcumin; Depsides; Dose-Response Relationship, Drug; In Vitro Techniques; Kinetics; Lipoxygenase Inhibitors; Masoprocol; Microscopy, Electron; Microscopy, Polarization; Neurofibrillary Tangles; Peptide Fragments; Platelet Aggregation Inhibitors; Rosmarinic Acid; Spectrometry, Fluorescence; Thiazoles; Time Factors | 2004 |
Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Topics: Adenoviridae; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Astrocytes; Benzothiazoles; Brain; Cells, Cultured; Cerebral Cortex; Cholestanetriol 26-Monooxygenase; Cholesterol 24-Hydroxylase; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Hydroxycholesterols; Immunoblotting; Immunohistochemistry; Inhibitory Concentration 50; Liver X Receptors; Neurons; Oligodendroglia; Orphan Nuclear Receptors; Polymorphism, Genetic; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Signal Transduction; Steroid Hydroxylases; Thiazoles; Time Factors | 2004 |
A seed for Alzheimer amyloid in the brain.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Antibody Specificity; Benzothiazoles; Brain; Brain Chemistry; Cell Survival; Cells, Cultured; G(M1) Ganglioside; Humans; Liposomes; Macaca fascicularis; Macromolecular Substances; Microscopy, Immunoelectron; Middle Aged; Neurons; Peptide Fragments; Rats; Rats, Sprague-Dawley; Thiazoles; Time Factors | 2004 |
Electron microscopy as a quantitative method for investigating tau fibrillization.
Topics: Alzheimer Disease; Benzothiazoles; Fatty Acids; Humans; Microscopy, Electron; Microspheres; Mutation; tau Proteins; Thiazoles; Time Factors | 2004 |
Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Humans; Immunoglobulin Variable Region; Microscopy, Atomic Force; Neuroblastoma; Neurons; Peptide Library; Plaque, Amyloid; Surface Plasmon Resonance; Thiazoles; Tumor Cells, Cultured | 2004 |
Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum.
Topics: Acetylcholine; Acetyltransferases; Aged; Aged, 80 and over; Alzheimer Disease; Basal Nucleus of Meynert; Benzothiazoles; Case-Control Studies; Cognition Disorders; Cohort Studies; Female; Histological Techniques; Humans; Immunohistochemistry; Longitudinal Studies; Male; Neurofibrillary Tangles; Neuropsychological Tests; Postmortem Changes; tau Proteins; Thiazoles | 2004 |
Inflammation occurs early during the Abeta deposition process in TgCRND8 mice.
Topics: Age Factors; Alzheimer Disease; Amygdala; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; CD11b Antigen; Disease Models, Animal; Glial Fibrillary Acidic Protein; Hippocampus; Immunohistochemistry; Inflammation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neocortex; Plaque, Amyloid; Thiazoles | 2004 |
Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Benzothiazoles; Down Syndrome; Female; Fluorescent Antibody Technique, Indirect; Humans; Immunohistochemistry; Male; Membrane Proteins; Mice; Mice, Transgenic; Middle Aged; Neocortex; Neurons; Non-Fibrillar Collagens; Peptide Fragments; Plaque, Amyloid; Thiazoles; Tissue Distribution | 2004 |
Oxidative stress impairs glutamate uptake in fibroblasts from patients with Alzheimer's disease.
Topics: Acetylcysteine; Adenosine Triphosphate; Aged; Aged, 80 and over; Aldehydes; Alzheimer Disease; Animals; Antioxidants; Case-Control Studies; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fibroblasts; Free Radicals; Glutamic Acid; Glutathione; Humans; L-Lactate Dehydrogenase; Lipid Peroxidation; Middle Aged; Oxidative Stress; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors | 2004 |
Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Benzothiazoles; Binding, Competitive; Brain; Carbon Radioisotopes; Cerebellum; Disease Models, Animal; Female; Frontal Lobe; Humans; Iodine Radioisotopes; Metabolic Clearance Rate; Mice; Mice, Transgenic; Molecular Structure; Plaque, Amyloid; Positron-Emission Tomography; Radioligand Assay; Thiazoles; Tomography, Emission-Computed, Single-Photon | 2004 |
Cholesterol, copper, and accumulation of thioflavine S-reactive Alzheimer's-like amyloid beta in rabbit brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Blood Vessels; Brain; Cholesterol; Copper; Disease Models, Animal; Drug Synergism; Food, Formulated; Immunohistochemistry; Male; Metabolic Clearance Rate; Neurons; Rabbits; Thiazoles; Up-Regulation | 2004 |
Nordihydroguaiaretic acid does not disaggregate beta-amyloid(1-40) protofibrils but does inhibit growth arising from direct protofibril association.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Fluorescence; Humans; Masoprocol; Peptide Fragments; Thiazoles | 2004 |
Morphological characterization of Thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Fluorescent Dyes; Heterozygote; Humans; Immunization, Passive; Immunotherapy; Metabolic Clearance Rate; Mice; Mice, Transgenic; Neurites; Neurofibrillary Tangles; Plaque, Amyloid; Thiazoles | 2004 |
Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Survival; Cells, Cultured; Hippocampus; Inhibitory Concentration 50; Neurons; Neuroprotective Agents; Plaque, Amyloid; Protein Structure, Quaternary; Rats; Solubility; Thiazoles | 2004 |
Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; beta Carotene; Cell Line; Dose-Response Relationship, Drug; Humans; Kinetics; Microscopy, Electron; Molecular Structure; Neurofibrils; Retinaldehyde; Thiazoles; Tretinoin; Vitamin A; Vitamins | 2004 |
Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease.
Topics: Alzheimer Disease; Amides; CDC2-CDC28 Kinases; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Drug Evaluation, Preclinical; Molecular Structure; Nerve Tissue Proteins; Structure-Activity Relationship; Thiazoles | 2004 |
Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Protein Precursor; Animals; Apolipoproteins E; Benzothiazoles; Cerebral Cortex; Disease Models, Animal; Intermediate Filament Proteins; Mice; Mice, Transgenic; Thiazoles | 2004 |
Amyloid-beta protofibrils differ from amyloid-beta aggregates induced in dilute hexafluoroisopropanol in stability and morphology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biochemistry; Chromatography; Circular Dichroism; Humans; Ions; Kinetics; Light; Microscopy, Atomic Force; Microscopy, Electron; Peptide Fragments; Propanols; Protein Conformation; Scattering, Radiation; Thiazoles; Time Factors | 2005 |
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Benzothiazoles; Biphenyl Compounds; Blood-Brain Barrier; Brain; Cell Line, Tumor; Congo Red; Curcumin; Diamines; Humans; Ibuprofen; Mice; Mice, Transgenic; Naproxen; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Denaturation; Protein Structure, Quaternary; Pyridazines; Solubility; Thiazoles | 2005 |
Evidence for the presence of three distinct binding sites for the thioflavin T class of Alzheimer's disease PET imaging agents on beta-amyloid peptide fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Binding, Competitive; Centrifugation, Density Gradient; Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Humans; Kinetics; Ligands; Models, Biological; Models, Chemical; Peptide Fragments; Peptides; Positron-Emission Tomography; Protein Binding; Spectrometry, Fluorescence; Thiazoles | 2005 |
Inhibition of amyloid fibrillogenesis and toxicity by a peptide chaperone.
Topics: alpha-Crystallins; Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Asparagine; Benzothiazoles; Cell Survival; Fluorescent Dyes; Humans; Molecular Chaperones; Molecular Sequence Data; PC12 Cells; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rats; Thiazoles; Toxicity Tests | 2004 |
Efficient radiosynthesis of carbon-11 labelled uncharged Thioflavin T derivatives using [11C]methyl triflate for beta-amyloid imaging in Alzheimer's Disease with PET.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Carbon Radioisotopes; Humans; Isotope Labeling; Mesylates; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2005 |
Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile.
Topics: Alzheimer Disease; Amides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Biological Availability; Blood-Brain Barrier; Dihydropyridines; Drug Delivery Systems; Endopeptidases; Enzyme Inhibitors; Humans; Male; Molecular Structure; Nicotinic Acids; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Thiazoles | 2005 |
Altered transcriptional regulators in response to serum in immortalized lymphocytes from Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Blotting, Western; Case-Control Studies; Cell Cycle; Cell Cycle Proteins; Cell Line; Cell Proliferation; Culture Media, Serum-Free; DNA-Binding Proteins; E2F Transcription Factors; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Female; Humans; Imidazoles; Lymphocyte Activation; Lymphocytes; Male; NF-kappa B; Phosphorylation; Serum; Tetrazolium Salts; Thiazoles; Time Factors; Transcription Factors | 2005 |
PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Disease Models, Animal; Feasibility Studies; Female; Metabolic Clearance Rate; Mice; Mice, Transgenic; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Tissue Distribution | 2005 |
Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Nerve Tissue Proteins; Non-Fibrillar Collagens; Peptide Fragments; Thiazoles | 2005 |
Delineation of positron emission tomography imaging agent binding sites on beta-amyloid peptide fibrils.
Topics: 1-Naphthylamine; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Congo Red; Contrast Media; Fluorescence; Humans; Positron-Emission Tomography; Radioligand Assay; Thiazoles | 2005 |
Proteolytic cleavage of extracellular secreted {alpha}-synuclein via matrix metalloproteinases.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Catalytic Domain; Cell Line, Tumor; Cell Survival; Coloring Agents; Culture Media; Dopamine; Humans; Immunohistochemistry; Insecta; Kinetics; Male; Matrix Metalloproteinase 3; Matrix Metalloproteinases; Nerve Tissue Proteins; Nitric Oxide; Nitrites; Oxidopamine; Oxygen; Parkinson Disease; Protein Binding; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substantia Nigra; Synucleins; Tetrazolium Salts; Thiazoles; Time Factors; Transfection | 2005 |
Protective effect of donepezil against Abeta(1-40) neurotoxicity in rat septal neurons.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Cholinergic Fibers; Cholinesterase Inhibitors; Donepezil; Down-Regulation; Fluorescent Dyes; Immunohistochemistry; Indans; L-Lactate Dehydrogenase; Membrane Transport Proteins; Molecular Structure; Neurons; Neuroprotective Agents; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Septal Nuclei; Thiazoles; Vesicular Acetylcholine Transport Proteins | 2005 |
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Cerebellar Cortex; Female; Humans; Image Processing, Computer-Assisted; Kinetics; Male; Memory Disorders; Middle Aged; Positron-Emission Tomography; Protein Binding; Radiography; Thiazoles | 2005 |
Purification of recombinant tau protein and preparation of Alzheimer-paired helical filaments in vitro.
Topics: Alzheimer Disease; Amyloid; Benzothiazoles; Cloning, Molecular; Humans; Microscopy, Electron; Protein Isoforms; Spectrometry, Fluorescence; tau Proteins; Thiazoles | 2005 |
Multiple ligand binding sites on A beta(1-40) fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Congo Red; Fluorescent Dyes; Humans; Ibuprofen; Ligands; Models, Chemical; Molecular Structure; Naproxen; Peptide Fragments; Protein Binding; Thiazoles | 2005 |
Sequence determinants of enhanced amyloidogenicity of Alzheimer A{beta}42 peptide relative to A{beta}40.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Biophysical Phenomena; Biophysics; Chromatography, High Pressure Liquid; DNA Primers; Green Fluorescent Proteins; Humans; Kinetics; Microscopy, Fluorescence; Models, Chemical; Mutation; Peptide Fragments; Peptide Library; Peptides; Phenotype; Protein Structure, Secondary; Recombinant Fusion Proteins; Sequence Analysis, Protein; Temperature; Thiazoles; Time Factors | 2005 |
Hydrogen peroxide is generated during the very early stages of aggregation of the amyloid peptides implicated in Alzheimer disease and familial British dementia.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dementia; Electron Spin Resonance Spectroscopy; Enzyme-Linked Immunosorbent Assay; Family Health; Humans; Hydrogen Peroxide; Microscopy, Atomic Force; Models, Statistical; Neurodegenerative Diseases; Oxidative Stress; Oxygen; Peptide Fragments; Peptides; Spin Trapping; Thiazoles; Time Factors; United Kingdom | 2005 |
Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Benzothiazoles; Blotting, Western; Brain; Enzyme-Linked Immunosorbent Assay; Gene Deletion; Heterozygote; Hippocampus; Mice; Mice, Transgenic; Models, Genetic; Protein Structure, Tertiary; Thiazoles; Time Factors | 2005 |
Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Apolipoproteins E; Atherosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Benzothiazoles; Blotting, Western; Brain; Cerebral Amyloid Angiopathy; Humans; Immunohistochemistry; Lipid Metabolism; Lipoproteins, HDL; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Mice, Transgenic; Mutation; Protein Isoforms; Thiazoles; Time Factors | 2005 |
Cerebrospinal fluid of Alzheimer patients promotes beta-amyloid fibril formation in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Brain Chemistry; Cerebrospinal Fluid; Humans; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Middle Aged; Peptide Fragments; Plaque, Amyloid; Polymers; Thiazoles | 2005 |
Inducible expression of Tau repeat domain in cell models of tauopathy: aggregation is toxic to cells but can be reversed by inhibitor drugs.
Topics: Alzheimer Disease; Amino Acid Motifs; Benzothiazoles; Brain; Cell Line; Cell Line, Tumor; Centrifugation, Density Gradient; Chromatography; DNA Fragmentation; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gene Deletion; Humans; Mass Spectrometry; Microscopy, Electron; Microscopy, Fluorescence; Models, Biological; Models, Chemical; Mutation; Neurons; Peptide Hydrolases; Phosphorylation; Plasmids; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; tau Proteins; Tauopathies; Thiazoles; Thrombin; Time Factors | 2006 |
In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice.
Topics: Age Factors; Alzheimer Disease; Animals; Benzothiazoles; Brain Mapping; Disease Models, Animal; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Plaque, Amyloid; Staining and Labeling; Thiazoles | 2005 |
Deficiency of disulfide bonds facilitating fibrillogenesis of endostatin.
Topics: Alanine; Alzheimer Disease; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Disulfides; Endostatins; Escherichia coli; Fibril-Associated Collagens; Fluorescent Dyes; Glutathione; Hydrogen-Ion Concentration; Light; Microscopy, Atomic Force; Neovascularization, Pathologic; PC12 Cells; Protein Conformation; Protein Structure, Tertiary; Rats; Scattering, Radiation; Spectroscopy, Fourier Transform Infrared; Temperature; Tetrazolium Salts; Thiazoles; Time Factors; Tryptophan; Ultraviolet Rays | 2006 |
Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Binding Sites; Brain; Female; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Positron-Emission Tomography; Thiazoles | 2005 |
Influence of heparin and dendrimers on the aggregation of two amyloid peptides related to Alzheimer's and prion diseases.
Topics: Alzheimer Disease; Amyloid; Benzothiazoles; Dendrimers; Heparin; Kinetics; Molecular Structure; Peptide Fragments; Prion Diseases; Spectrometry, Fluorescence; Thiazoles | 2006 |
Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Brain; Carotid Arteries; Female; Humans; Image Interpretation, Computer-Assisted; Image Processing, Computer-Assisted; Kinetics; Male; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles; Time Factors | 2005 |
Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Benzothiazoles; Blotting, Western; Brain; Congo Red; Endopeptidases; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Heterozygote; Hippocampus; Immunohistochemistry; Membrane Proteins; Mice; Mice, Transgenic; Microscopy, Electron; Mutation; Mutation, Missense; Neurons; Peptide Fragments; Phosphorylation; Presenilin-1; Protein Conformation; Sodium Dodecyl Sulfate; tau Proteins; Thiazoles | 2006 |
Oxorhenium(V) and oxotechnetium(V) [NN][S]3 complexes of 2-phenylbenzothiazole derivatives.
Topics: Alzheimer Disease; Cell Line, Tumor; Crystallography, X-Ray; Humans; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Organometallic Compounds; Organotechnetium Compounds; Oxidation-Reduction; Phenols; Radiopharmaceuticals; Rhenium; Sensitivity and Specificity; Stereoisomerism; Sulfhydryl Compounds; Technetium; Thiazoles | 2006 |
Beneficial effects of perospirone on aggressive behavior associated with dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Dementia, Vascular; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Indoles; Isoindoles; Mental Status Schedule; Psychomotor Agitation; Thiazoles; Treatment Outcome | 2006 |
M1 receptors play a central role in modulating AD-like pathology in transgenic mice.
Topics: ADAM Proteins; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Antibodies, Monoclonal; Basigin; Behavior, Animal; Blotting, Western; Brain; Cell Count; Cytoskeletal Proteins; Dicyclomine; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Escape Reaction; Gene Expression; GTP-Binding Proteins; Humans; Immunohistochemistry; Memory Disorders; Mice; Mice, Transgenic; Muscarinic Antagonists; Nuclear Proteins; Piperidines; Protein Kinase C; Reaction Time; Receptor, Muscarinic M1; Spatial Behavior; Spiro Compounds; tau Proteins; Thiazoles; Time Factors | 2006 |
Drug shows promise for treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Humans; Mice; Piperidines; Receptor, Muscarinic M1; Spiro Compounds; Thiazoles | 2006 |
Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Fluorescent Dyes; Microscopy, Atomic Force; Thiazoles; Uncaria | 2006 |
Frontotemporal dementia: clinicopathological correlations.
Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Brain; Dementia; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Inclusion Bodies; Male; Middle Aged; Neurodegenerative Diseases; Neuropsychological Tests; Tauopathies; Thiazoles; Ubiquitin | 2006 |
Memory-related deficits following selective hippocampal expression of Swedish mutation amyloid precursor protein in the rat.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Benzothiazoles; Disease Models, Animal; Fluoresceins; Gene Expression; Genetic Vectors; Hippocampus; Humans; Immunohistochemistry; Male; Maze Learning; Memory Disorders; Mutation; Organic Chemicals; Peptide Fragments; Rats; Rats, Sprague-Dawley; Thiazoles | 2006 |
Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblasts.
Topics: Adult; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Apoptosis; Case-Control Studies; Caspase 3; Cells, Cultured; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Extracellular Fluid; Family Health; Fibroblasts; Humans; Middle Aged; Oxidative Stress; Plaque, Amyloid; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles; Time Factors | 2007 |
Amyloid load and cerebral atrophy in Alzheimer's disease: an 11C-PIB positron emission tomography study.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Atrophy; Brain; Carbon Radioisotopes; Cohort Studies; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2006 |
Lipophilic analogs of thioflavin S as novel amyloid-imaging agents.
Topics: Affinity Labels; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding, Competitive; Carbon Radioisotopes; Diagnostic Imaging; Drug Evaluation, Preclinical; Fluorescent Dyes; Humans; Iodine Radioisotopes; Mice; Molecular Structure; Neurofibrillary Tangles; Plaque, Amyloid; Protein Binding; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2006 |
Two-year follow-up of amyloid deposition in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Brain; Cholinesterase Inhibitors; Cognition Disorders; Disease Progression; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Psychiatric Status Rating Scales; Radiopharmaceuticals; Thiazoles | 2006 |
[11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Biomarkers; Carbon Radioisotopes; Humans; Middle Aged; Radiopharmaceuticals; Thiazoles | 2006 |
Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Cerebellum; Cerebral Cortex; Contrast Media; Female; Fluorodeoxyglucose F18; Glucose; Humans; Image Processing, Computer-Assisted; Male; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2006 |
Characteristics of the binding of thioflavin S to tau paired helical filaments.
Topics: Alzheimer Disease; Antibodies, Blocking; Benzothiazoles; Fluorescent Antibody Technique; Heparin Lyase; Humans; Microscopy, Electron; Microscopy, Fluorescence; Neurofilament Proteins; Protein Binding; Quinones; tau Proteins; Thiazoles | 2006 |
Development of amyloid imaging PET probes for an early diagnosis of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzoxazoles; Early Diagnosis; Humans; Mice; Plaque, Amyloid; Positron-Emission Tomography; Thiazoles | 2006 |
Voxel-based analysis of PET amyloid ligand [11C]PIB uptake in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Brain Mapping; Carbon Radioisotopes; Cerebral Cortex; Corpus Striatum; Female; Humans; Image Processing, Computer-Assisted; Ligands; Male; Middle Aged; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles; Up-Regulation | 2006 |
Cerebrospinal fluid of Alzheimer's disease and dementia with Lewy bodies patients enhances alpha-synuclein fibril formation in vitro.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Benzothiazoles; Female; Humans; Immunoglobulin G; Lewy Body Disease; Male; Microscopy, Electron; Middle Aged; Psychiatric Status Rating Scales; Spectrometry, Fluorescence; tau Proteins; Thiazoles | 2007 |
Linear quantitation of Abeta aggregation using Thioflavin T: reduction in fibril formation by colostrinin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Biological Assay; Biomarkers; Dose-Response Relationship, Drug; Down-Regulation; Fluorescence; Fluorescent Dyes; Humans; Intercellular Signaling Peptides and Proteins; Linear Models; Microscopy, Fluorescence; Molecular Weight; Neurochemistry; Neuroprotective Agents; Peptide Fragments; Peptides; Plaque, Amyloid; Solubility; Thiazoles | 2007 |
Amyloid, hypometabolism, and cognition in Alzheimer disease: an [11C]PIB and [18F]FDG PET study.
Topics: Aged; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Cognition; Face; Female; Fluorodeoxyglucose F18; Glucose; Humans; Language; Male; Mental Recall; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Radiopharmaceuticals; Recognition, Psychology; Thiazoles | 2007 |
Potential inplications of endogenous aldehydes in beta-amyloid misfolding, oligomerization and fibrillogenesis.
Topics: Aldehydes; Alzheimer Disease; Amine Oxidase (Copper-Containing); Amyloid beta-Peptides; Benzothiazoles; Brain; Cell Adhesion Molecules; Fluorometry; Formaldehyde; Humans; Lipid Peroxidation; Malondialdehyde; Microscopy, Atomic Force; Neurofibrillary Tangles; Oxidative Stress; Polymers; Protein Folding; Proteomics; Pyruvaldehyde; Spectrum Analysis; Thiazoles | 2006 |
Proline and glycine control protein self-organization into elastomeric or amyloid fibrils.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Benzothiazoles; Chickens; Elastin; Entropy; Glycine; Humans; Insecta; Models, Molecular; Molecular Sequence Data; Peptides; Proline; Protein Conformation; Thiazoles; Triticum | 2006 |
Monoclonal antibodies that target pathological assemblies of Abeta.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antibodies, Monoclonal; Antibody Specificity; Brain; Calmodulin-Binding Proteins; Cells, Cultured; Dose-Response Relationship, Drug; Epitopes; Glial Fibrillary Acidic Protein; Humans; Immunoblotting; Immunohistochemistry; Mice; Neurons; Peptide Fragments; Protein Binding; Rabbits; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2007 |
Dementia: important advances in research in 2006.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Atrophy; Biomarkers; Brain; Dementia; Humans; Prognosis; tau Proteins; Temporal Lobe; Thiazoles | 2007 |
Clubbed thiazoles by MAOS: a novel approach to cyclin-dependent kinase 5/p25 inhibitors as a potential treatment for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Chlorocebus aethiops; Cyclin-Dependent Kinase 5; Drug Evaluation, Preclinical; Enzyme Inhibitors; Indicators and Reagents; Magnetic Resonance Spectroscopy; Microwaves; Structure-Activity Relationship; Thiazoles; Vero Cells | 2007 |
Pittsburgh compound B retention and verification of amyloid deposition.
Topics: Alzheimer Disease; Amyloid; Aniline Compounds; Animals; Humans; Thiazoles | 2007 |
Visual assessment versus quantitative assessment of 11C-PIB PET and 18F-FDG PET for detection of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Carbon Radioisotopes; Cohort Studies; Female; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Models, Statistical; Observer Variation; ROC Curve; Thiazoles | 2007 |
2-(2-[2-Dimethylaminothiazol-5-yl]ethenyl)-6- (2-[fluoro]ethoxy)benzoxazole: a novel PET agent for in vivo detection of dense amyloid plaques in Alzheimer's disease patients.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Animals; Benzoxazoles; Female; Humans; Male; Mice; Mice, Transgenic; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2007 |
11C-PIB PET imaging in Alzheimer disease and frontotemporal lobar degeneration.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Benzothiazoles; Brain; Dementia; Diagnosis, Differential; Humans; Image Enhancement; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles | 2007 |
Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain; Computer Simulation; Female; Humans; Image Interpretation, Computer-Assisted; Male; Metabolic Clearance Rate; Middle Aged; Models, Neurological; Positron-Emission Tomography; Radiopharmaceuticals; Reference Values; Reproducibility of Results; Sensitivity and Specificity; Thiazoles | 2007 |
PET amyloid ligand [11C]PIB uptake is increased in mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Brain; Brain Mapping; Cognition Disorders; Female; Humans; Male; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles | 2007 |
PET imaging of amyloid deposition in patients with mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Benzothiazoles; Cerebral Cortex; Cognition Disorders; Disease Progression; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Predictive Value of Tests; Prognosis; Thiazoles | 2008 |
Imaging beta-amyloid burden in aging and dementia.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Brain Chemistry; Carbon Radioisotopes; Cognition Disorders; Dementia; Female; Gyrus Cinguli; Humans; Lewy Body Disease; Magnetic Resonance Imaging; Male; Middle Aged; Neocortex; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2007 |
Analytical method for beta-amyloid fibrils using CE-laser induced fluorescence and its application to screening for inhibitors of beta-amyloid protein aggregation.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Daunorubicin; Fluorescence; Fluorescent Dyes; Humans; Indoles; Lasers; Mass Screening; Melatonin; Molecular Sequence Data; Propionates; Sensitivity and Specificity; Thiazoles; Time Factors | 2007 |
Formation of toxic fibrils of Alzheimer's amyloid beta-protein-(1-40) by monosialoganglioside GM1, a neuronal membrane component.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Membrane; Chromatography, Gel; Circular Dichroism; G(M1) Ganglioside; Microscopy, Electron, Transmission; Neurons; PC12 Cells; Peptide Fragments; Protein Structure, Secondary; Rats; Thiazoles | 2007 |
A novel approach to cyclin-dependent kinase 5/p25 inhibitors: A potential treatment for Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Cyclin-Dependent Kinase 5; Enzyme Inhibitors; Humans; Microwaves; Nerve Tissue Proteins; Structure-Activity Relationship; Thiazoles; Ticrynafen | 2007 |
Imaging of amyloid burden and distribution in cerebral amyloid angiopathy.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biopsy; Cerebral Amyloid Angiopathy; Cerebral Hemorrhage; Cohort Studies; Education; Female; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Occipital Lobe; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2007 |
PIB is a non-specific imaging marker of amyloid-beta (Abeta) peptide-related cerebral amyloidosis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Biomarkers; Brain; Carbon Radioisotopes; Humans; Positron-Emission Tomography; Thiazoles | 2007 |
Evaluating atypical dementia syndromes using positron emission tomography with carbon 11 labeled Pittsburgh Compound B.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Aphasia, Primary Progressive; Atrophy; Brain; Carbon Radioisotopes; Dementia; Female; Humans; Male; Middle Aged; Parietal Lobe; Positron-Emission Tomography; Syndrome; Thiazoles; Tissue Distribution | 2007 |
TgCRND8 amyloid precursor protein transgenic mice exhibit an altered gamma-secretase processing and an aggressive, additive amyloid pathology subject to immunotherapeutic modulation.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Immunotherapy; Mice; Mice, Transgenic; Molecular Sequence Data; Plaque, Amyloid; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thiazoles | 2007 |
Influence of Hypericum perforatum extract and its single compounds on amyloid-beta mediated toxicity in microglial cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Catechin; Cell Membrane; Cell Survival; Humans; Hypericum; L-Lactate Dehydrogenase; Microglia; Models, Chemical; Phagocytosis; Plant Extracts; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2007 |
Differentiating Alzheimer disease-associated aggregates with small molecules.
Topics: alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Mass Spectrometry; Neurofibrillary Tangles; Peptide Library; Plaque, Amyloid; tau Proteins; Thiazines; Thiazoles | 2007 |
In vivo amyloid imaging with PET in frontotemporal dementia.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Aniline Compounds; Benzothiazoles; Case-Control Studies; Dementia; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Positron-Emission Tomography; Thiazoles | 2008 |
Coumarin derivatives protection against ROS production in cellular models of Abeta toxicities.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Coumarins; Free Radicals; Humans; Hydrogen Peroxide; Mice; Mice, Transgenic; Models, Chemical; Mutation; Oxidative Stress; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2007 |
Thioflavin derivatives as markers for amyloid-beta fibrils: insights into structural features important for high-affinity binding.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Biomarkers; Heterocyclic Compounds; Peptides; Protein Structure, Tertiary; Structure-Activity Relationship; Thiazoles | 2008 |
Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Apolipoproteins E; Benzothiazoles; Biomarkers; Carbon Radioisotopes; Case-Control Studies; Cerebellar Cortex; Chi-Square Distribution; Cognition Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Mutation; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2007 |
Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Antibodies; Disease Models, Animal; Female; Inflammation; Longitudinal Studies; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurofibrillary Tangles; Positron-Emission Tomography; Thiazoles | 2007 |
Congo red and thioflavin-T analogs detect Abeta oligomers.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cell Line, Tumor; Coloring Agents; Congo Red; Fluorescent Dyes; Hippocampus; Humans; Microscopy, Electron, Transmission; Neuroblastoma; Surface Plasmon Resonance; Thiazoles | 2008 |
Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aniline Compounds; Apolipoproteins E; Benzothiazoles; Brain; Brain Chemistry; Dementia; Female; Fluorodeoxyglucose F18; Functional Laterality; Genotype; Glucose; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Radiopharmaceuticals; Thiazoles | 2008 |
Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Carbon Radioisotopes; Cerebral Cortex; Cerebrovascular Circulation; Disease Susceptibility; Educational Status; Energy Metabolism; Female; Fluorodeoxyglucose F18; Glucose; Humans; Male; Middle Aged; Neuropsychological Tests; Plaque, Amyloid; Positron-Emission Tomography; Recovery of Function; Thiazoles | 2008 |
Anti-amyloidogenic activity of S-allyl-L-cysteine and its activity to destabilize Alzheimer's beta-amyloid fibrils in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzothiazoles; Cysteine; Humans; Macromolecular Substances; Microscopy, Electron, Transmission; Neuroprotective Agents; Protein Binding; Protein Conformation; Protein Folding; Thiazoles | 2007 |
[11C]PIB binding in Parkinson's disease dementia.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Dementia; Diagnosis, Differential; Female; Humans; Lewy Body Disease; Male; Melanins; Microscopy, Fluorescence; Middle Aged; Neuropsychological Tests; Parkinson Disease; Protein Structure, Secondary; Radionuclide Imaging; Radiopharmaceuticals; Thiazoles | 2008 |
Spline based inhomogeneity correction for 11C-PIB PET segmentation using expectation maximization.
Topics: Aged; Algorithms; Alzheimer Disease; Aniline Compounds; Artifacts; Artificial Intelligence; Brain; Female; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Likelihood Functions; Male; Pattern Recognition, Automated; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity; Thiazoles | 2007 |
Apoptotic death induces Abeta production and fibril formation to a much larger extent than necrotic-like death in CGNs.
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Apoptosis; Benzothiazoles; Cerebellum; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Fluorescent Dyes; Humans; Huntington Disease; Membrane Proteins; Microfilament Proteins; Microscopy, Electron, Transmission; Necrosis; Parkinson Disease; Reticulin; Thiazoles | 2007 |
[Amyloid imaging].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Brain Chemistry; Humans; Radionuclide Imaging; Thiazoles | 2007 |
11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Amnesia; Aniline Compounds; Brain Mapping; Carbon Radioisotopes; Cognition Disorders; Diagnosis, Differential; Female; Hippocampus; Humans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Positron-Emission Tomography; Thiazoles | 2008 |
A multimeric quinacrine conjugate as a potential inhibitor of Alzheimer's beta-amyloid fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Dose-Response Relationship, Drug; Drug Design; Microscopy, Atomic Force; Protein Binding; Quinacrine; Spectrometry, Fluorescence; Thiazoles | 2008 |
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Autopsy; Brain; Carbon Radioisotopes; Enzyme-Linked Immunosorbent Assay; Female; Humans; Image Interpretation, Computer-Assisted; Immunohistochemistry; Magnetic Resonance Imaging; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Positron-Emission Tomography; Reproducibility of Results; tau Proteins; Thiazoles | 2008 |
Clinical severity of Alzheimer's disease is associated with PIB uptake in PET.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aniline Compounds; Brain; Brain Mapping; Female; Humans; Linear Models; Male; Middle Aged; Positron-Emission Tomography; Severity of Illness Index; Signal Processing, Computer-Assisted; Thiazoles | 2009 |
Differences between normal and alpha-synuclein overexpressing SH-SY5Y neuroblastoma cells after Abeta(1-42) and NAC treatment.
Topics: alpha-Synuclein; Alzheimer Disease; Amphotericin B; Amyloid; Amyloid beta-Peptides; Cell Differentiation; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Molecular Weight; Neuroblastoma; Peptide Fragments; Ruthenium Red; Tetrazolium Salts; Thiazoles; Time Factors | 2008 |
Carbon 11-labeled pittsburgh compound B positron emission tomographic amyloid imaging in patients with APP locus duplication.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Aniline Compounds; Brain; Carbon Radioisotopes; Caudate Nucleus; Cerebral Amyloid Angiopathy, Familial; Dominance, Cerebral; Female; Gene Duplication; Gyrus Cinguli; Hippocampus; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Parietal Lobe; Positron-Emission Tomography; Protease Nexins; Putamen; Receptors, Cell Surface; Sensitivity and Specificity; Temporal Lobe; Thiazoles | 2008 |
Biological characters of [18F]O-FEt-PIB in a rat model of Alzheimer's disease using micro-PET imaging.
Topics: Algorithms; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Animals; Brain; Diagnostic Imaging; Disease Models, Animal; Fluorodeoxyglucose F18; Hippocampus; Male; Peptide Fragments; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Thalamus; Thiazoles; Tissue Distribution | 2008 |
Imaging beta-amyloid burden in aging and dementia.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Carbon Radioisotopes; Dementia; Early Diagnosis; False Positive Reactions; Humans; Informed Consent; Middle Aged; Positron-Emission Tomography; Predictive Value of Tests; Thiazoles | 2008 |
Posterior parahippocampal gyrus pathology in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Female; Humans; Immunohistochemistry; Male; Neurofibrillary Tangles; Neurofilament Proteins; Parahippocampal Gyrus; Parvalbumins; Thiazoles | 2008 |
Dendritic reorganisation in the basal forebrain under degenerative conditions and its defects in Alzheimer's disease. II. Ageing, Korsakoff's disease, Parkinson's disease, and Alzheimer's disease.
Topics: Adult; Aged; Aging; Alcohol Amnestic Disorder; Alzheimer Disease; Benzothiazoles; Cell Count; Dendrites; Female; Fluorescent Dyes; Histocytochemistry; Humans; Male; Middle Aged; Nerve Degeneration; Neuronal Plasticity; Parkinson Disease; Prosencephalon; Staining and Labeling; Thiazoles | 1995 |
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filaments.
Topics: Alzheimer Disease; Benzothiazoles; Brain; Cysteine; Fluorescent Dyes; Humans; Neurofibrillary Tangles; Oxidation-Reduction; Phosphorylation; Protein Conformation; Sulfhydryl Reagents; tau Proteins; Thiazoles | 1995 |
Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Benzothiazoles; Female; Hippocampus; Humans; Immunoblotting; Immunohistochemistry; Male; Middle Aged; Neurofilament Proteins; Neurons; Reference Values; Thiazoles | 1994 |
Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Astrocytes; Autoradiography; Brain; Female; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Isoquinolines; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Picolinic Acids; Thiazoles | 1994 |
Two types of dystrophic neurites in senile plaques of Alzheimer disease and elderly non-demented cases.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Antigens; Benzothiazoles; Cerebral Cortex; Chromogranin A; Chromogranins; Fluorescent Dyes; Humans; Immunohistochemistry; Neurites; tau Proteins; Thiazoles; Ubiquitins | 1994 |
Neuritic involvement within bFGF immunopositive plaques of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Biomarkers; Child; Child, Preschool; Down Syndrome; Fibroblast Growth Factor 2; Fluorescent Dyes; Heparitin Sulfate; Humans; Immunohistochemistry; Middle Aged; Nerve Fibers; Neurites; Neurofibrillary Tangles; Thiazoles | 1993 |
Alzheimer's disease-type neurofibrillary degeneration in verrucose dysplasias of the cerebral cortex.
Topics: Aged; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Cholinesterases; Female; Fluorescent Dyes; Humans; Immunohistochemistry; Male; Nerve Degeneration; Neurofibrillary Tangles; tau Proteins; Thiazoles; Tissue Fixation | 1995 |
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Benzothiazoles; Binding Sites; Brain; Butyrylcholinesterase; Cattle; Fluorescent Dyes; Humans; Mice; Microscopy, Electron; Mutation; Neurofibrils; Propidium; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles | 1996 |
Neurotoxicity of a carboxyl-terminal fragment of the Alzheimer's amyloid precursor protein.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Humans; Neuroprotective Agents; Neurotoxins; Oxidation-Reduction; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Thiazoles | 1996 |
First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Kinetics; Models, Biological; Peptide Fragments; Temperature; Thiazoles | 1996 |
Relative efficacies of amyloid beta peptide (A beta) binding proteins in A beta aggregation.
Topics: alpha 1-Antichymotrypsin; Alzheimer Disease; Amyloid beta-Peptides; Apolipoproteins E; Benzothiazoles; Complement C1q; Humans; Prealbumin; Protein Binding; Serum Amyloid P-Component; Spectrometry, Fluorescence; Thiazoles | 1996 |
Self-assembly of the brain MAP-2 microtubule-binding region into polymeric structures resembling Alzheimer filaments.
Topics: Alzheimer Disease; Amino Acid Sequence; Animals; Benzothiazoles; Brain; Cattle; Fluorescent Dyes; Microtubule-Associated Proteins; Molecular Sequence Data; Peptide Fragments; Polymers; Protein Binding; Recombinant Proteins; Thiazoles | 1996 |
The "nonamyloidogenic" p3 fragment (amyloid beta17-42) is a major constituent of Down's syndrome cerebellar preamyloid.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Down Syndrome; Electrophoresis, Polyacrylamide Gel; Fluorometry; Humans; Mass Spectrometry; Thiazoles | 1996 |
Neurofibrillary tangles in the dentate granule cells of patients with Alzheimer's disease, Lewy body disease and progressive supranuclear palsy.
Topics: Alzheimer Disease; Antibodies, Monoclonal; Benzothiazoles; Dentate Gyrus; Fluorescent Dyes; Humans; Immunohistochemistry; Microscopy, Immunoelectron; Neurofibrillary Tangles; Parkinson Disease; Supranuclear Palsy, Progressive; Thiazoles | 1997 |
Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Carnosine; Cognition; Cross-Linking Reagents; Fructose; Glycation End Products, Advanced; Guanidines; Humans; Memory; Neuropeptide Y; Particle Size; Peptide Fragments; Piperazines; Protein Structure, Secondary; Solubility; Temperature; Thiazoles; Thiophenes | 1997 |
The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Calbindin 2; Cerebral Cortex; Cross Reactions; Fluorescent Antibody Technique; Fluorescent Dyes; Frontal Lobe; Humans; Middle Aged; Nerve Tissue Proteins; Neurites; Neurofilament Proteins; Parvalbumins; Phosphorylation; S100 Calcium Binding Protein G; Staining and Labeling; Thiazoles | 1997 |
Stopped-flow kinetics reveal multiple phases of thioflavin T binding to Alzheimer beta (1-40) amyloid fibrils.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Benzothiazoles; Binding Sites; Fluorescence; Fluorescent Dyes; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Molecular Sequence Data; Molecular Structure; Naphthalenesulfonates; Osmolar Concentration; Peptide Fragments; Protein Binding; Protein Conformation; Protein Structure, Secondary; Sodium Chloride; Temperature; Thiazoles | 1997 |
Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Animals; Astrocytes; Benzothiazoles; Brain; Cerebral Amyloid Angiopathy; Humans; Mice; Mice, Inbred BALB C; Mice, Transgenic; Thiazoles; Transforming Growth Factor beta | 1997 |
Butyrylcholinesterase in the life cycle of amyloid plaques.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Butyrylcholinesterase; Case-Control Studies; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Plaque, Amyloid; Temporal Lobe; Thiazoles | 1997 |
Rat microglia exhibit increased density on Alzheimer's plaques in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Benzothiazoles; Brain; Carbocyanines; Cell Count; Cells, Cultured; Fluorescent Dyes; Humans; Lipoproteins, LDL; Microglia; Middle Aged; Plaque, Amyloid; Rats; Rats, Sprague-Dawley; Reference Values; Thiazoles | 1998 |
Sympathetic neurite outgrowth is greater on plaque-poor vs. plaque-rich regions of Alzheimer's disease cryostat sections.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Animals; Benzothiazoles; Case-Control Studies; Chick Embryo; Cryopreservation; Fluorescent Dyes; Humans; Neurites; Plaque, Amyloid; Sympathetic Nervous System; Thiazoles | 1998 |
The neurotoxicity of amyloid beta protein in aged primates.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Antigens; Benzothiazoles; Brain; Female; Haplorhini; Immunohistochemistry; Male; Microinjections; Microscopy, Fluorescence; Neurons; Peptide Fragments; Thiazoles; Ubiquitins | 1998 |
Relationship between plaques, tangles, and loss of cortical cholinergic fibers in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cerebral Cortex; Choline O-Acetyltransferase; Fluorescent Dyes; Humans; Nerve Fibers; Neurofibrillary Tangles; Organ Specificity; Plaque, Amyloid; Reference Values; Regression Analysis; Thiazoles | 1998 |
Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution.
Topics: Alzheimer Disease; Benzothiazoles; Buffers; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Neurofibrillary Tangles; Polyelectrolytes; Polymers; Protein Structure, Secondary; Salts; Solutions; Spectrometry, Fluorescence; tau Proteins; Temperature; Thiazoles | 1998 |
The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease.
Topics: Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biomarkers; Cells, Cultured; Cerebral Cortex; Electron Spin Resonance Spectroscopy; Free Radical Scavengers; Neuroprotective Agents; Oxidation-Reduction; Peptide Fragments; Rats; Rats, Sprague-Dawley; Synaptosomes; Tetrazolium Salts; Thiazoles; Vitamin E | 1998 |
ApoE associated with lipid has a reduced capacity to inhibit beta-amyloid fibril formation.
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloidosis; Apolipoproteins E; Benzothiazoles; Cholesterol; Fluorescent Dyes; Humans; Neurofibrillary Tangles; Thiazoles | 1998 |
S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase.
Topics: Alzheimer Disease; Aminopeptidases; Brain; Calpain; Cell Line; Cell Membrane; Cell Membrane Permeability; Cell Nucleus; Endopeptidases; Humans; Hydrolysis; Indoles; Inhibitory Concentration 50; Kinetics; Peptidyl-Dipeptidase A; Prolyl Oligopeptidases; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Thiazoles; Thiazolidines | 1999 |
The levels of soluble versus insoluble brain Abeta distinguish Alzheimer's disease from normal and pathologic aging.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Antibodies, Monoclonal; Benzothiazoles; Brain; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Peptide Fragments; Plaque, Amyloid; Reference Values; Solubility; Thiazoles | 1999 |
The molecular chaperone alphaB-crystallin enhances amyloid beta neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apoptosis; Benzothiazoles; Cell Survival; Cells, Cultured; Cerebral Cortex; Crystallins; Dose-Response Relationship, Drug; Hippocampus; Molecular Chaperones; Neurons; Peptide Fragments; Plaque, Amyloid; Protein Binding; Protein Structure, Secondary; Rats; Thiazoles | 1999 |
Amyloid beta-peptide-associated free radical oxidative stress, neurotoxicity, and Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cell Count; Cerebral Cortex; Creatine Kinase; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Glutamate-Ammonia Ligase; Hippocampus; Humans; Mitochondria; Neurons; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Spin Labels; Synaptosomes; Tetrazolium Salts; Thiazoles; Trypan Blue | 1999 |
Common structural features determine the effectiveness of carvedilol, daunomycin and rolitetracycline as inhibitors of Alzheimer beta-amyloid fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Carbazoles; Carvedilol; Cell Survival; Daunorubicin; Humans; Inhibitory Concentration 50; Microscopy, Electron; Models, Chemical; Molecular Structure; Neurons; Polymers; Propanolamines; Protein Binding; Rolitetracycline; Structure-Activity Relationship; Tetrazolium Salts; Thermodynamics; Thiazoles; Tumor Cells, Cultured | 1999 |
Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Astrocytes; Brain; Cell Differentiation; Chromans; Cyclooxygenase 2; Dinoprost; Genes, Reporter; Humans; Inflammation; Interleukin-6; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; Microbodies; Microglia; Monocytes; Peptide Fragments; Prostaglandin-Endoperoxide Synthases; Receptors, Cytoplasmic and Nuclear; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidinediones; Transcription Factors; Transfection; Troglitazone; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2000 |
Alzheimer's disease presenilin-1 exon 9 deletion and L250S mutations sensitize SH-SY5Y neuroblastoma cells to hyperosmotic stress-induced apoptosis.
Topics: Alzheimer Disease; Apoptosis; Brain Neoplasms; Cell Movement; Coloring Agents; Gene Deletion; Glucose; Humans; Hypertonic Solutions; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Membrane Proteins; Mutation; Neurites; Neuroblastoma; Osmotic Pressure; Presenilin-1; Signal Transduction; Tetrazolium Salts; Thiazoles; Transfection; Tumor Cells, Cultured | 2000 |
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Benzothiazoles; Disease Models, Animal; Genetic Predisposition to Disease; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Nerve Degeneration; Neurites; Plaque, Amyloid; Protein Isoforms; Thiazoles; Time Factors | 2000 |
Orbitofrontal cortex pathology in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Dyes; Frontal Lobe; Humans; Middle Aged; Neurofibrillary Tangles; Organ Size; Plaque, Amyloid; Thiazoles | 2000 |
High density lipoprotein inhibits assembly of amyloid beta-peptides into fibrils.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Fluorometry; Humans; Lipoproteins, HDL; Nerve Tissue Proteins; Particle Size; Peptide Fragments; Plaque, Amyloid; Protein Binding; Solubility; Thiazoles | 2000 |
Toxicity of non-abeta component of Alzheimer's disease amyloid, and N-terminal fragments thereof, correlates to formation of beta-sheet structure and fibrils.
Topics: alpha-Synuclein; Alzheimer Disease; Amino Acid Sequence; Amyloid; Animals; Cell Survival; Circular Dichroism; Humans; Microscopy, Electron; Molecular Sequence Data; Nerve Tissue Proteins; Oxidation-Reduction; PC12 Cells; Peptide Fragments; Protein Structure, Secondary; Rats; Solubility; Synucleins; Tetrazolium Salts; Thiazoles; Time Factors | 2000 |
Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antioxidants; Apoptosis; Cell Survival; CHO Cells; Chromans; Cricetinae; Dimethyl Sulfoxide; Humans; Hydrogen Peroxide; Neuroblastoma; Oxidative Stress; Peptide Fragments; Phosphatidylserines; RNA, Messenger; Tetrazolium Salts; Thiazoles; Transfection; Tumor Cells, Cultured | 2000 |
Human apolipoprotein C-II forms twisted amyloid ribbons and closed loops.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Apolipoprotein C-II; Apolipoproteins C; Benzothiazoles; Chromatography, Gel; Circular Dichroism; Congo Red; Humans; Microscopy, Electron; Protein Conformation; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Ultracentrifugation | 2000 |
X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology.
Topics: Aged; Aged, 80 and over; Alkenes; Alzheimer Disease; Amyloid; Amyloidosis; Benzoates; Benzothiazoles; Coloring Agents; Congo Red; Female; Fluorescent Dyes; Histocytochemistry; Humans; Male; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Protein Structure, Secondary; Silver; Thiazoles | 2000 |
Interaction between beta-amyloid and lens alphaB-crystallin.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Circular Dichroism; Crystallins; Humans; Recombinant Proteins; Spectrometry, Fluorescence; Thiazoles; Tryptophan; Ultraviolet Rays | 2000 |
Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy.
Topics: Alzheimer Disease; Animals; Benzothiazoles; Disease Models, Animal; Disease Progression; Feedback; Fluorescent Dyes; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy; Plaque, Amyloid; Thiazoles | 2001 |
Anti-amyloidogenic activity of tetracyclines: studies in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Doxycycline; Fluorescent Dyes; Humans; Hydrolysis; In Vitro Techniques; Macromolecular Substances; Microscopy, Electron; Peptide Fragments; Tetracycline; Tetracyclines; Thiazoles; Trypsin | 2001 |
Complement association with neurons and beta-amyloid deposition in the brains of aged individuals with Down Syndrome.
Topics: Adult; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Complement C1q; Down Syndrome; Encephalitis; Female; Humans; Immunohistochemistry; Male; Microglia; Middle Aged; Neurofibrillary Tangles; Neurons; Plaque, Amyloid; Thiazoles | 2001 |
Promotion of formation of amyloid fibrils by aluminium adenosine triphosphate (AlATP).
Topics: Adenosine; Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Fluorescent Dyes; Humans; Islet Amyloid Polypeptide; Organometallic Compounds; Suramin; Thiazoles | 2001 |
Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Autoradiography; Benzene Derivatives; Blood-Brain Barrier; Brain; Down Syndrome; Humans; Indicators and Reagents; Iodine Radioisotopes; Isotope Labeling; Kinetics; Ligands; Mice; Peptide Fragments; Structure-Activity Relationship; Styrenes; Thiazoles; Tissue Distribution | 2001 |
Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.
Topics: Alkaloids; Alzheimer Disease; Animals; Cell Size; Cell Survival; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Glucose; Hypoxia-Ischemia, Brain; Indans; Lipid Peroxidation; Malondialdehyde; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Piperidines; Rats; Sesquiterpenes; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2001 |
The relationship between the aggregational state of the amyloid-beta peptides and free radical generation by the peptides.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cell Survival; Circular Dichroism; Electron Spin Resonance Spectroscopy; Fluorescent Dyes; Free Radicals; Humans; PC12 Cells; Rats; Thiazoles | 2001 |
Reduction of cerebrospinal fluid amyloid beta after systemic administration of M1 muscarinic agonists.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cerebrospinal Fluid; Female; Muscarinic Agonists; Neurons; Peptide Fragments; Piperidines; Quinuclidines; Rabbits; Receptor, Muscarinic M1; Receptors, Muscarinic; Thiazoles; Thiophenes | 2001 |
Fibrillar beta-amyloid evokes oxidative damage in a transgenic mouse model of Alzheimer's disease.
Topics: Aging; Aldehydes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Disease Models, Animal; Immunohistochemistry; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Nerve Degeneration; Neurofibrillary Tangles; Oxidative Stress; Thiazoles; Tyrosine | 2001 |
Inhibition of beta-amyloid(40) fibrillogenesis and disassembly of beta-amyloid(40) fibrils by short beta-amyloid congeners containing N-methyl amino acids at alternate residues.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acids; Amyloid beta-Peptides; Benzothiazoles; Chymotrypsin; Drug Resistance; Humans; Methylation; Microscopy, Fluorescence; Molecular Sequence Data; Peptide Fragments; Protein Structure, Secondary; Protein Structure, Tertiary; Thiazoles; Ultracentrifugation | 2001 |
Statistical aspects of quantitative image analysis of beta-amyloid in the APP(V717F) transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Cell Count; Data Interpretation, Statistical; Disease Models, Animal; Hippocampus; Image Processing, Computer-Assisted; Male; Mice; Mice, Transgenic; Microscopy, Fluorescence; Plaque, Amyloid; Reproducibility of Results; Statistical Distributions; Thiazoles | 2001 |
The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Cerebral Cortex; Fluorescent Dyes; Humans; Immunohistochemistry; Microscopy, Confocal; Nerve Degeneration; Neurites; Neurofilament Proteins; Phenotype; Plaque, Amyloid; tau Proteins; Thiazoles | 2001 |
Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption.
Topics: Action Potentials; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Dendrites; In Vitro Techniques; Mice; Mice, Transgenic; Microscopy, Confocal; Models, Neurological; Neurites; Plaque, Amyloid; Reaction Time; Thiazoles | 2001 |
Radiolabeled muscarinic radioligands for in vivo studies.
Topics: Alzheimer Disease; Fluorine Radioisotopes; Humans; Iodine Radioisotopes; Muscarinic Agonists; Pyridines; Quinuclidinyl Benzilate; Radioligand Assay; Receptors, Muscarinic; Thiazoles | 2001 |
Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Brain; Chemical Phenomena; Chemistry, Physical; Female; Fluorescent Dyes; Histocytochemistry; Hydrogen-Ion Concentration; Mice; Protein Binding; Solubility; Spectrometry, Fluorescence; Thiazoles; Tomography, Emission-Computed | 2001 |
Plasmin cleaves Abeta42 in vitro and prevents its aggregation into beta-pleated sheet structures.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Brain; Chromatography, High Pressure Liquid; Drug Interactions; Fibrinolysin; Humans; Peptide Fragments; Protein Structure, Secondary; Thiazoles | 2001 |
Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Assay; Cell Death; Cell Survival; Cells, Cultured; Cerebral Cortex; Coloring Agents; Dose-Response Relationship, Drug; Drug Interactions; Fetus; Hydrogen Peroxide; Neurons; Neuroprotective Agents; Peptide Fragments; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Tetrazolium Salts; Thiazoles; Thioctic Acid | 2001 |
Relationship of calbindin D28K-immunoreactive cells and neuropathological changes in the hippocampal formation of Alzheimer's disease.
Topics: Age of Onset; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Benzothiazoles; Calbindin 1; Calbindins; Female; Fluorescent Dyes; Hippocampus; Humans; Immunohistochemistry; Male; Middle Aged; Neurofibrillary Tangles; Plaque, Amyloid; Pyramidal Cells; S100 Calcium Binding Protein G; Thiazoles | 2001 |
Melatonin protects SHSY5Y neuroblastoma cells from cobalt-induced oxidative stress, neurotoxicity and increased beta-amyloid secretion.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cobalt; Glutathione; Humans; Melatonin; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2001 |
Early formation of mature amyloid-beta protein deposits in a mutant APP transgenic model depends on levels of Abeta(1-42).
Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Benzothiazoles; Brain; Congo Red; Disease Models, Animal; Gene Expression Regulation, Developmental; Mice; Mice, Neurologic Mutants; Mice, Transgenic; Microscopy, Electron; Mutagenesis, Insertional; Mutation; Neurites; Neurons; Peptide Fragments; Plaque, Amyloid; Presynaptic Terminals; Promoter Regions, Genetic; Thiazoles | 2001 |
The role of the MAP-kinase superfamily in beta-amyloid toxicity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Blotting, Western; Coloring Agents; Dose-Response Relationship, Drug; Hydrogen Peroxide; In Vitro Techniques; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neuroblastoma; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 2001 |
A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain.
Topics: Alzheimer Disease; Amyloid; Animals; Benzothiazoles; Binding, Competitive; Brain; Chemical Phenomena; Chemistry, Physical; Mice; Mice, Transgenic; Microscopy; Plaque, Amyloid; Radiopharmaceuticals; Structure-Activity Relationship; Thiazoles; Tomography, Emission-Computed | 2002 |
Inhibition by R(+) or S(-) pramipexole of caspase activation and cell death induced by methylpyridinium ion or beta amyloid peptide in SH-SY5Y neuroblastoma.
Topics: 1-Methyl-4-phenylpyridinium; Alzheimer Disease; Amyloid beta-Peptides; Anti-Bacterial Agents; Aristolochic Acids; Benzothiazoles; Bongkrekic Acid; Brain; Caspase Inhibitors; Caspases; Cell Death; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Humans; Neuroblastoma; Neurodegenerative Diseases; Neurons; Parkinson Disease; Peptide Fragments; Phenanthrenes; Pramipexole; Thiazoles; Tumor Cells, Cultured | 2002 |
A liposome-based therapeutic vaccine against beta -amyloid plaques on the pancreas of transgenic NORBA mice.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Enzyme-Linked Immunosorbent Assay; Immune Sera; Immunity; Liposomes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; Palmitic Acid; Pancreas; Peptides; Species Specificity; Thiazoles; Time Factors; Vaccines | 2002 |
Type IV collagen prevents amyloid beta-protein fibril formation.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Circular Dichroism; Collagen Type IV; Dose-Response Relationship, Drug; Fluorescent Dyes; Humans; Microscopy, Electron; Peptide Fragments; Spectrometry, Fluorescence; Thiazoles | 2002 |
Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Benzothiazoles; Cerebral Amyloid Angiopathy; Chromatography, High Pressure Liquid; Formazans; Humans; Molecular Sequence Data; PC12 Cells; Peptide Fragments; Protein Conformation; Protein Structure, Secondary; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship; Thiazoles | 2002 |
Reduction of trophic support enhances apoptosis in PC12 cells expressing Alzheimer's APP mutation and sensitizes cells to staurosporine-induced cell death.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Culture Media; DNA Fragmentation; Enzyme Inhibitors; Flow Cytometry; Humans; In Situ Nick-End Labeling; L-Lactate Dehydrogenase; Mutation; Neurons; Oxidative Stress; PC12 Cells; Rats; Staurosporine; Tetrazolium Salts; Thiazoles | 2002 |
An improved thioflavine S method for staining neurofibrillary tangles and senile plaques in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Fluorescent Dyes; Hippocampus; Humans; Neurofibrillary Tangles; Staining and Labeling; Thiazoles | 1992 |
A comparative study of histological and immunohistochemical methods for neurofibrillary tangles and senile plaques in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Humans; Immunohistochemistry; Neurofibrillary Tangles; Staining and Labeling; Thiazoles | 1992 |
Single-dose and steady-state pharmacokinetics of sabeluzole in senile dementia of Alzheimer type patients.
Topics: Aged; Alzheimer Disease; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Piperidines; Thiazoles | 1992 |
Racemized D-aspartate in Alzheimer neurofibrillary tangles.
Topics: Alzheimer Disease; Aspartic Acid; Benzothiazoles; Chromatography, Gas; Fluorescent Dyes; Humans; Nerve Tissue Proteins; Neurofibrillary Tangles; Stereoisomerism; Thiazoles | 1992 |
Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Female; Humans; Male; Middle Aged; Nerve Degeneration; Neurons; Staining and Labeling; Thiazoles | 1990 |
Senile dementia of the Alzheimer type: is there a correlation between entorhinal cortex and dentate gyrus lesions?
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Dementia, Vascular; Female; Hippocampus; Humans; Immunohistochemistry; Middle Aged; Neurofibrillary Tangles; tau Proteins; Thiazoles | 1991 |
Evidence for axonal loss in regions occupied by senile plaques in Alzheimer cortex.
Topics: Alzheimer Disease; Amyloid; Axons; Benzothiazoles; Cytoskeleton; Fluorescent Antibody Technique; Fluorescent Dyes; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Nerve Tissue Proteins; Neurofilament Proteins; Thiazoles | 1991 |
[Neuropathologic study of 50 cases of senile dementia].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloidosis; Benzothiazoles; Brain; Cerebrovascular Disorders; Dementia; Dementia, Vascular; Female; Fluorescent Dyes; Humans; Male; Middle Aged; Prospective Studies; Thiazoles | 1990 |
Hypothalamic pathology in Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Benzothiazoles; Cerebral Cortex; Female; Hippocampus; Humans; Hypothalamus; Male; Middle Aged; Neurofibrils; Staining and Labeling; Thiazoles | 1987 |
Observation of morphological relationships between angiopathic blood vessels and degenerative neurites in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Benzothiazoles; Brain; Cerebrovascular Disorders; Congo Red; Female; Humans; Neurofibrils; Staining and Labeling; Thiazoles | 1987 |
Transformation of degenerating neurofibrils into amyloid substance in Alzheimer's disease: histochemical and immunohistochemical studies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Benzothiazoles; Brain; Histocytochemistry; Humans; Immunohistochemistry; Nerve Degeneration; Neurofibrils; Staining and Labeling; Thiazoles | 1987 |
Does amyloid precede paired helical filaments in the senile plaque? A study of 15 cases with graded intellectual status in aging and Alzheimer disease.
Topics: Aged; Aging; Alzheimer Disease; Amyloid; Benzothiazoles; Brain; Female; Humans; Immunohistochemistry; Intermediate Filaments; Staining and Labeling; Thiazoles | 1988 |
[Alzheimer's disease: immunohistochemical characterization of cerebral amyloid deposits].
Topics: Alzheimer Disease; Amyloid; Antibodies; Benzothiazoles; Cerebral Cortex; Fluorescent Dyes; Glycoside Hydrolases; Humans; Immunohistochemistry; Periodic Acid; Thiazoles | 1989 |
Monoclonal antibody to embryonic CNS antigen A2B5 provides evidence for the involvement of membrane components at sites of Alzheimer degeneration and detects sulfatides as well as gangliosides.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Antigens, Surface; Benzothiazoles; Brain Chemistry; Cell Membrane; Chick Embryo; Fluorescent Antibody Technique; Frontal Lobe; Gangliosides; Hippocampus; Histocytochemistry; Humans; Immunoenzyme Techniques; Mice; Neurofibrils; Retina; Sulfoglycosphingolipids; Thiazoles | 1989 |
Alzheimer's disease. Arresting memory decline.
Topics: Alzheimer Disease; Animals; Carbolines; Cholinesterase Inhibitors; Humans; Memory Disorders; Nicotine; Piperidines; Rats; Receptors, Cholinergic; Receptors, GABA-A; Receptors, Nicotinic; Thiazoles | 1988 |
[Quantitative analysis of the distribution of acetylcholinesterase-positive senile plaques in the hippocampal formation in patients with senile dementia of Alzheimer type].
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Hippocampus; Humans; Thiazoles | 1988 |
Cortical angiopathy in Alzheimer's disease: the formation of dystrophic perivascular neurites is related to the exudation of amyloid fibrils from the pathological vessels.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid; Arterioles; Benzothiazoles; Capillaries; Cerebral Cortex; Fluorescent Dyes; Humans; Immunohistochemistry; Nerve Fibers; Thiazoles | 1988 |
Flow cytometric purification of Alzheimer's disease amyloid plaque core protein using thioflavin T.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Benzothiazoles; Brain Chemistry; Flow Cytometry; Fluorescent Dyes; Humans; Lipofuscin; Microscopy, Fluorescence; Spectrometry, Fluorescence; Thiazoles | 1987 |
Comparison of methods for analysis of CSF proteins in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzothiazoles; Cerebrospinal Fluid Proteins; Electrophoresis; Humans; Microscopy, Electron; Middle Aged; Silver; Thiazoles | 1987 |
Neuronal pathology in the nucleus basalis and associated cell groups in senile dementia of the Alzheimer's type: possible role in cell loss.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Basal Ganglia; Benzothiazoles; Brain; Female; Humans; Male; Neurofibrils; Phenothiazines; Substantia Innominata; Thiazoles | 1985 |