Page last updated: 2024-08-21

thiazoles and ALS - Amyotrophic Lateral Sclerosis

thiazoles has been researched along with ALS - Amyotrophic Lateral Sclerosis in 66 studies

Research

Studies (66)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	40 (60.61)	18.2507
2000's	5 (7.58)	29.6817
2010's	18 (27.27)	24.3611
2020's	3 (4.55)	2.80

Authors

Authors	Studies
Boopathy, S; Brown, RH; Danielson, EW; Fallini, C; Giampetruzzi, A; Gumina, V; Jeon, M; Landers, JE; Ratti, A	1
van Den Berg, LH; van Eijk, RPA	1
Chen, JJ	1
Alamón, C; Barbeito, L; Hermine, O; Ibarburu, S; King, PH; Kovacs, M; Kwon, Y; Maciel, C; Si, Y; Tarragó, L; Trias, E; Varela, V	1
Scott, A	1
Barbeito, L; Barreto-Núñez, R; Beckman, JS; Dubreuil, P; Hermine, O; Ibarburu, S; Moura, IC; Trias, E; Varela, V	1
Kiernan, MC	1
Barbeito, L; Beckman, JS; Hermine, O; Ibarburu, S; King, PH; Kovacs, M; Kwon, Y; Moura, IC; Si, Y; Trias, E; Varela, V	1
Dolgin, E	1
Che, X; Ding, X; Feng, S; Ma, M; Teng, J; Wang, X; Wu, E; Zhang, W; Zhang, Y; Zhou, S	1
Camacho, J; Gamez, J; Salvado, M; Simon-Talero, M; Vargas, V; Vidal, M	1
Babdor, J; Barbeito, L; Barreto-Núñez, R; Beckman, JS; Cassina, P; Díaz-Amarilla, P; Dubreuil, P; Gros, L; Guillo, M; Hermine, O; Ibarburu, S; Maciel, TT; Martínez-Palma, L; Moura, IC; Trias, E	1
Drannik, A; Jiang, F; Ma, X; Peterson, R; Turnbull, J	1
Chia, R; Collinge, J; Fisher, EM; Jackson, GS; Jones, S; Tattum, MH	1
Fan, D; Tang, L; Wang, J; Zhang, N; Zhang, Y	1
Ahn, SW; Choi, WJ; Hong, YH; Kim, JE; Kim, SH; Kim, SM; Lee, KW; Park, KS; Sung, JJ	1
Hadano, S; Hirayama, N; Ikeda, JE; Kanno, T; Tanaka, K; Yanagisawa, Y; Yasutake, K; Yoshii, F	1
Adachi, H; Huang, Z; Ishigaki, S; Katsumata, R; Katsuno, M; Kawai, K; Sobue, G; Sone, J; Tanaka, F; Urano, F	1
Botelho, HM; Cardoso, I; Fritz, G; Gomes, CM; Leal, SS; Morozova-Roche, LA; Yanamandra, K	1
Gardberg, M; Jansson, L; Kaasinen, V; Martikainen, MH; Rinne, JO; Röyttä, M	1
Chen, YR; Chiang, CH; Kuo, PH; Liang, JR; Shen, JC; Wang, S; Wang, YT; Yuan, HS	1
Cashman, NR; Chakrabartty, A; Crow, JP; Cunningham, P; Dahan, S; Furtos-Matei, A; Kondejewski, LH; Qi, XF; Rakhit, R	1
Beretta, S; Carrì, MT; Casciati, A; Ceresa, C; Ferrarese, C; Ferri, A; Mattavelli, L; Sala, G	1
Bennett, JP; Gerber, RE; Pattee, GL; Post, GR	1
Bendotti, C; Cantoni, L; Lupi, M; Mangolini, A; Rizzardini, M; Ubezio, P	1
Hwang, S; Kim, HY; Kim, SH; Kim, Y; Koh, SH; Lee, CH	1
Nightingale, SL	1
Rowland, LP	2
Burgerman, RS	1
McRae, KD	1
Murphy, JR	1
Rogawski, MA	1
Couratier, P; Esclaire, F; Hugon, J; Louvel, E; Sindou, P	1
Fuller, GN; McKee, P; Stevens, DL	1
Bensimon, G; Lacomblez, L; Meininger, V	1
Bensimon, G; Guillet, P; Lacomblez, L; Leigh, PN; Meininger, V	1
Emami, J; Goonetilleke, A; Guiloff, RJ	1
Martí-Fàbregas, J	1
Andrus, PK; Cutting, FB; Gurney, ME; Hall, ED; Zhai, P	1
Festoff, BW	1
Wokke, J	1
Bouchard, JP; Duquette, P; Eisen, A; Gelinas, D; Harati, Y; Miller, RG; Munsat, TL; Powe, L; Rothstein, J; Salzman, P; Sufit, RL	1
Newman, D; Sufit, R	1
Hugon, J	1
Hobbs, GR; Riggs, JE	1
Bensimon, G; Delumeau, JC; Durrleman, S; Guillet, P; Lacomblez, L; Leigh, PN; Meininger, V; Powe, L	1
Barnes, S	1
Andrus, PK; Cutting, FB; Doble, A; Gurney, ME; Hall, ED; Taylor, CP; Zhai, P	1
Wokke, JH	1
Moriwaka, F	1
Andersen, PM; Forsgren, L; Sojka, P	1
Klappenbach, G; Ludolph, AC; Riepe, MW	1
Shindo, M; Yanagisawa, N	1
Scarlato, G	1
Aubin, F; Dib, M; Jourdain, G; Meininger, V; Zeisser, P	1
Ince, PG; Shaw, PJ	1
Dengler, R; Tröger, M	1
Landis, BE; Wagner, ML	1
Mitsumoto, H	1
Clark, W; Kendall, MJ	1
Brown, RH; Cudkowicz, ME; Ellis, T; Gwilt, PR; Hayden, DL; Sexton, PM; Whalen, J	1

Reviews

11 review(s) available for thiazoles and ALS - Amyotrophic Lateral Sclerosis

Article	Year
Amyotrophic lateral sclerosis. Current opinion in neurology, 1994, Volume: 7, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Humans; Immunization, Passive; Motor Neuron Disease; Neurologic Examination; Riluzole; Thiazoles	1994
Pathogenic mechanisms in familial amyotrophic lateral sclerosis due to mutation of Cu, Zn superoxide dismutase. Pathologie-biologie, 1996, Volume: 44, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Animals; Chromosome Aberrations; Chromosome Disorders; Chromosomes, Human, Pair 21; Excitatory Amino Acid Antagonists; Humans; Mice; Mice, Transgenic; Mutation; Riluzole; Superoxide Dismutase; Thiazoles; Vitamin E	1996
Amyotrophic lateral sclerosis: current and future treatment strategies. Drugs, 1996, Volume: 51, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Apoptosis; Ciliary Neurotrophic Factor; Clinical Trials as Topic; Humans; Insulin-Like Growth Factor I; Nerve Tissue Proteins; Riluzole; Thiazoles	1996
Riluzole. Lancet (London, England), 1996, Sep-21, Volume: 348, Issue:9030 Topics: Amyotrophic Lateral Sclerosis; Animals; Drug Interactions; Female; Humans; Male; Middle Aged; Motor Neuron Disease; Neuroprotective Agents; Riluzole; Thiazoles	1996
Riluzole and ALS therapy. Wiener medizinische Wochenschrift (1946), 1996, Volume: 146, Issue:9-10 Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Motor Neurons; Neurologic Examination; Riluzole; Survival Analysis; Thiazoles	1996
[Amyotrophic lateral sclerosis]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 1997, Volume: 72, Issue:1 Topics: Adult; Amino Acids, Branched-Chain; Amyotrophic Lateral Sclerosis; Animals; Autoimmunity; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Nerve Growth Factors; Nerve Tissue Proteins; Point Mutation; Randomized Controlled Trials as Topic; Riluzole; Superoxide Dismutase; Thiazoles; Threonine	1997
Glutamate, excitotoxicity and amyotrophic lateral sclerosis. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Neuroprotective Agents; Receptors, Glutamate; Riluzole; Thiazoles	1997
Impact of riluzole on the relationship between patient and physician. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Attitude; Disease Progression; Emotions; Humans; Neuroprotective Agents; Physician-Patient Relations; Physicians; Riluzole; Thiazoles	1997
Riluzole: a new agent for amyotrophic lateral sclerosis. The Annals of pharmacotherapy, 1997, Volume: 31, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Drug Interactions; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Riluzole; Thiazoles	1997
Therapeutic advances: riluzole for the treatment of motor neurone disease. Journal of clinical pharmacy and therapeutics, 1996, Volume: 21, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Asthenia; Excitatory Amino Acid Antagonists; Health Care Costs; Humans; Quality of Life; Riluzole; Survivors; Thiazoles; Treatment Outcome	1996
Riluzole for amyotrophic lateral sclerosis. Drug and therapeutics bulletin, 1997, Volume: 35, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Riluzole; Thiazoles	1997

Trials

10 trial(s) available for thiazoles and ALS - Amyotrophic Lateral Sclerosis

Article	Year
Reduction of oxidative stress in amyotrophic lateral sclerosis following pramipexole treatment. Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases, 2003, Volume: 4, Issue:2 Topics: Aged; Amyotrophic Lateral Sclerosis; Antioxidants; Benzothiazoles; Humans; Hydroxybenzoates; Middle Aged; Oxidative Stress; Patient Dropouts; Pramipexole; Thiazoles	2003
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. The New England journal of medicine, 1994, Mar-03, Volume: 330, Issue:9 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prognosis; Proportional Hazards Models; Prospective Studies; Riluzole; Survival Analysis; Thiazoles; Treatment Outcome	1994
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet (London, England), 1996, May-25, Volume: 347, Issue:9013 Topics: Amyotrophic Lateral Sclerosis; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neuroprotective Agents; Prognosis; Proportional Hazards Models; Riluzole; Survival Analysis; Thiazoles; Time Factors; Tracheostomy; Treatment Outcome	1996
Clinical trials of riluzole in patients with ALS. ALS/Riluzole Study Group-II. Neurology, 1996, Volume: 47, Issue:4 Suppl 2 Topics: Adult; Amyotrophic Lateral Sclerosis; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Liver; Male; Middle Aged; Neuroprotective Agents; Riluzole; Thiazoles	1996
Riluzole and ALS therapy. Wiener medizinische Wochenschrift (1946), 1996, Volume: 146, Issue:9-10 Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Motor Neurons; Neurologic Examination; Riluzole; Survival Analysis; Thiazoles	1996
A confirmatory dose-ranging study of riluzole in ALS. ALS/Riluzole Study Group-II. Neurology, 1996, Volume: 47, Issue:6 Suppl 4 Topics: Amyotrophic Lateral Sclerosis; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Humans; Male; Middle Aged; Riluzole; Survival Analysis; Thiazoles	1996
Effects of riluzole on symptom progression in amyotrophic lateral sclerosis. Lancet (London, England), 1997, Jan-18, Volume: 349, Issue:9046 Topics: Amyotrophic Lateral Sclerosis; Female; Humans; Male; Middle Aged; Neuroprotective Agents; Riluzole; Thiazoles	1997
Increase of flexor reflex latency in patients with amyotrophic lateral sclerosis treated with riluzole. Journal of neurology, neurosurgery, and psychiatry, 1997, Volume: 62, Issue:4 Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Female; Humans; Male; Middle Aged; Reaction Time; Reflex, Stretch; Riluzole; Thiazoles	1997
The Riluzole Early Access Programme: descriptive analysis of 844 patients in France. ALS/Riluzole Study Group III. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Aged; Amyotrophic Lateral Sclerosis; Female; France; Humans; Male; Middle Aged; Neuroprotective Agents; Riluzole; Risk; Survival Analysis; Thiazoles; Time Factors; Tracheostomy; Treatment Failure; Treatment Outcome	1997
The pharmacokinetics and pharmaco-dynamics of Procysteine in amyotrophic lateral sclerosis. Neurology, 1999, Apr-22, Volume: 52, Issue:7 Topics: Administration, Oral; Adult; Amyotrophic Lateral Sclerosis; Glutathione; Humans; Infusions, Intravenous; Middle Aged; Pyrrolidonecarboxylic Acid; Thiazoles; Thiazolidines	1999

Other Studies

46 other study(ies) available for thiazoles and ALS - Amyotrophic Lateral Sclerosis

Article	Year
Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis. Nature communications, 2019, 08-23, Volume: 10, Issue:1 Topics: Acrylamides; Actins; Active Transport, Cell Nucleus; Amyotrophic Lateral Sclerosis; Biopsy; Bridged Bicyclo Compounds, Heterocyclic; C9orf72 Protein; Cell Line; Cerebral Cortex; Embryo, Mammalian; Fibroblasts; Humans; Microscopy, Electron, Transmission; Motor Neurons; Mutation; Nuclear Pore; Primary Cell Culture; Profilins; Protein Multimerization; Skin; Thiazoles; Thiazolidines	2019
In pursuit of the normal progressor: the holy grail for ALS clinical trial design? Amyotrophic lateral sclerosis & frontotemporal degeneration, 2020, Volume: 21, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Benzamides; Clinical Trials as Topic; Humans; Piperidines; Pyridines; Riluzole; Thiazoles	2020
Overview of current and emerging therapies for amytrophic lateral sclerosis. The American journal of managed care, 2020, Volume: 26, Issue:9 Suppl Topics: Amyotrophic Lateral Sclerosis; Antibodies, Monoclonal, Humanized; Benzamides; Edaravone; Humans; Mesenchymal Stem Cells; Oligonucleotides; Piperidines; Pyridines; Riluzole; Thiazoles	2020
The pathogenic role of c-Kit+ mast cells in the spinal motor neuron-vascular niche in ALS. Acta neuropathologica communications, 2021, 08-13, Volume: 9, Issue:1 Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Animals; Astrocytes; Benzamides; Case-Control Studies; Chymases; Cyclooxygenase 2; Female; Humans; Male; Mast Cells; Mice; Microvessels; Middle Aged; Motor Neurons; Neuroinflammatory Diseases; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-kit; Pyridines; Spinal Cord; Stem Cell Factor; Thiazoles; Tryptases	2021
Drug therapy: On the treatment trail for ALS. Nature, 2017, 10-18, Volume: 550, Issue:7676 Topics: Amyotrophic Lateral Sclerosis; Antipyrine; Benzamides; C9orf72 Protein; Clinical Trials as Topic; Disease Progression; Drug Therapy, Combination; Edaravone; Genetic Therapy; Humans; Imidazoles; Mesenchymal Stem Cells; Motor Neurons; Neuroglia; Off-Label Use; Oligoribonucleotides, Antisense; Piperidines; Precision Medicine; Pyrazines; Pyridines; Riluzole; RNAi Therapeutics; Stem Cell Transplantation; Superoxide Dismutase; Thiazoles; United States; United States Food and Drug Administration	2017
Evidence for mast cells contributing to neuromuscular pathology in an inherited model of ALS. JCI insight, 2017, 10-19, Volume: 2, Issue:20 Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Benzamides; Disease Models, Animal; Male; Mast Cells; Muscle, Skeletal; Neuromuscular Diseases; Neuromuscular Junction; Piperidines; Pyridines; Rats; Thiazoles	2017
Motor neuron disease in 2017: Progress towards therapy in motor neuron disease. Nature reviews. Neurology, 2018, Volume: 14, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Benzamides; Edaravone; Humans; Muscular Atrophy, Spinal; Neuroprotective Agents; Oligonucleotides; Oligoribonucleotides, Antisense; Piperidines; Pyridines; Thiazoles; Thionucleotides	2018
Mast cells and neutrophils mediate peripheral motor pathway degeneration in ALS. JCI insight, 2018, 10-04, Volume: 3, Issue:19 Topics: Amyotrophic Lateral Sclerosis; Animals; Axons; Benzamides; Cell Degranulation; Disease Models, Animal; Humans; Male; Mast Cells; Motor Neurons; Muscle, Skeletal; Neuromuscular Junction; Neutrophil Infiltration; Neutrophils; Piperidines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Transgenic; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Treatment Outcome	2018
The brain's traffic problems. Science (New York, N.Y.), 2019, Jan-18, Volume: 363, Issue:6424 Topics: Acrylamides; Active Transport, Cell Nucleus; Amyotrophic Lateral Sclerosis; Animals; Brain; C9orf72 Protein; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Eye; GTPase-Activating Proteins; Mutation; Neurodegenerative Diseases; Nuclear Envelope; Nuclear Pore; Thiazoles	2019
Valproate Attenuates 25-kDa C-Terminal Fragment of TDP-43-Induced Neuronal Toxicity via Suppressing Endoplasmic Reticulum Stress and Activating Autophagy. International journal of biological sciences, 2015, Volume: 11, Issue:7 Topics: Amyotrophic Lateral Sclerosis; Animals; Autophagy; Cell Line; DNA-Binding Proteins; Endoplasmic Reticulum Stress; Flow Cytometry; Immunoblotting; Mice; Neurons; Peptide Fragments; Tetrazolium Salts; Thiazoles; Valproic Acid	2015
Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient. World journal of gastroenterology, 2015, Sep-28, Volume: 21, Issue:36 Topics: Adult; Amyotrophic Lateral Sclerosis; Azathioprine; Benzamides; Biopsy; Chemical and Drug Induced Liver Injury; Drug Therapy, Combination; Female; Hepatitis, Autoimmune; Humans; Immunosuppressive Agents; Piperidines; Prednisone; Protein Kinase Inhibitors; Pyridines; Randomized Controlled Trials as Topic; Severity of Illness Index; Thiazoles; Time Factors; Treatment Outcome	2015
Post-paralysis tyrosine kinase inhibition with masitinib abrogates neuroinflammation and slows disease progression in inherited amyotrophic lateral sclerosis. Journal of neuroinflammation, 2016, 07-11, Volume: 13, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Animals; Benzamides; Cell Death; Disease Models, Animal; Disease Progression; Encephalitis; Humans; Male; Motor Neurons; Mutation; Neuroglia; Paralysis; Piperidines; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Transgenic; Spinal Cord; Superoxide Dismutase; Thiazoles	2016
Crosstalk between Notch and Sonic hedgehog signaling in a mouse model of amyotrophic lateral sclerosis. Neuroreport, 2017, Feb-08, Volume: 28, Issue:3 Topics: Amyotrophic Lateral Sclerosis; Animals; CD11b Antigen; Diamines; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Hedgehog Proteins; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Proteins; Receptors, Notch; Signal Transduction; Spinal Cord; Superoxide Dismutase; Thiazoles; Zinc Finger Protein Gli2	2017
Superoxide dismutase 1 and tgSOD1 mouse spinal cord seed fibrils, suggesting a propagative cell death mechanism in amyotrophic lateral sclerosis. PloS one, 2010, May-13, Volume: 5, Issue:5 Topics: Amyloid; Amyotrophic Lateral Sclerosis; Animals; Benzothiazoles; Cell Death; Humans; Kinetics; Mice; Mice, Transgenic; Microscopy, Electron; Protein Stability; Spinal Cord; Subcellular Fractions; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Time Factors	2010
Protective effects of resveratrol through the up-regulation of SIRT1 expression in the mutant hSOD1-G93A-bearing motor neuron-like cell culture model of amyotrophic lateral sclerosis. Neuroscience letters, 2011, Oct-10, Volume: 503, Issue:3 Topics: Amyotrophic Lateral Sclerosis; Annexin A5; Blotting, Western; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescent Antibody Technique; Humans; Mitochondria; Motor Neurons; Mutation; Neuroprotective Agents; Niacinamide; Propidium; Real-Time Polymerase Chain Reaction; Resveratrol; Sirtuin 1; Stilbenes; Superoxide Dismutase; Superoxide Dismutase-1; Tetrazolium Salts; Thiazoles; Up-Regulation	2011
The neuroprotective effect of the GSK-3β inhibitor and influence on the extrinsic apoptosis in the ALS transgenic mice. Journal of the neurological sciences, 2012, Sep-15, Volume: 320, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Animals; Apoptosis; Caspase 8; Cell Count; Disease Models, Animal; fas Receptor; Fas-Associated Death Domain Protein; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Mice; Mice, Transgenic; Motor Neurons; Neuroprotective Agents; Phosphorylation; Rotarod Performance Test; Signal Transduction; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Urea	2012
A novel small molecule, N-(4-(2-pyridyl)(1,3-thiazol-2-yl))-2-(2,4,6-trimethylphenoxy) acetamide, selectively protects against oxidative stress-induced cell death by activating the Nrf2-ARE pathway: therapeutic implications for ALS. Free radical biology & medicine, 2012, Dec-01, Volume: 53, Issue:11 Topics: Acetamides; Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Antioxidant Response Elements; Apoptosis; Apoptosis Regulatory Proteins; Cell Survival; Drug Evaluation, Preclinical; Enzyme Induction; Enzyme Inhibitors; Female; Free Radical Scavengers; Gene Expression Regulation; Glutamate-Cysteine Ligase; HeLa Cells; Heme Oxygenase-1; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lipid Peroxidation; Male; Metabolic Detoxication, Phase II; Mice; Mice, Transgenic; NAD(P)H Dehydrogenase (Quinone); NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Thiazoles	2012
c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis. PloS one, 2012, Volume: 7, Issue:9 Topics: Amyotrophic Lateral Sclerosis; Animals; Dasatinib; Disease Models, Animal; Mice; Motor Neurons; Phosphorylation; Proto-Oncogene Proteins c-abl; Pyrimidines; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles	2012
S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation. The Journal of biological chemistry, 2012, Dec-07, Volume: 287, Issue:50 Topics: Amyloid; Amyotrophic Lateral Sclerosis; Benzothiazoles; Calcium; Cell Cycle Proteins; Cell Line, Tumor; Humans; Kinetics; Protein Structure, Quaternary; Protein Structure, Secondary; S100 Calcium Binding Protein A6; S100 Proteins; Spectroscopy, Fourier Transform Infrared; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles	2012
Brain ¹⁸F-FDG and ¹¹C-PiB PET findings in two siblings with FTD/ALS associated with the C9ORF72 repeat expansion. Neurocase, 2014, Volume: 20, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Aniline Compounds; Brain; C9orf72 Protein; Diagnosis, Differential; DNA Repeat Expansion; Female; Fluorodeoxyglucose F18; Frontotemporal Dementia; Humans; Male; Middle Aged; Neurons; Positron-Emission Tomography; Proteins; Siblings; Thiazoles	2014
The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates. The Journal of biological chemistry, 2013, Mar-29, Volume: 288, Issue:13 Topics: Amino Acid Motifs; Amyloidogenic Proteins; Amyotrophic Lateral Sclerosis; Benzothiazoles; Chromatography; Circular Dichroism; Dimerization; DNA-Binding Proteins; DNA, Complementary; Frontotemporal Lobar Degeneration; Glutathione Transferase; Glycine; Humans; Neurodegenerative Diseases; Peptides; Protein Binding; Protein Denaturation; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Scattering, Radiation; Thiazoles; X-Rays	2013
Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis. The Journal of biological chemistry, 2002, Dec-06, Volume: 277, Issue:49 Topics: Amino Acids; Amyotrophic Lateral Sclerosis; Benzothiazoles; Binding Sites; Chromatography, Liquid; Circular Dichroism; Erythrocytes; Humans; Hydrogen-Ion Concentration; Light; Microscopy, Atomic Force; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Neurons; Oxygen; Protein Binding; Protein Folding; Scattering, Radiation; Superoxide Dismutase; Thiazoles; Zinc	2002
Mitochondrial dysfunction due to mutant copper/zinc superoxide dismutase associated with amyotrophic lateral sclerosis is reversed by N-acetylcysteine. Neurobiology of disease, 2003, Volume: 13, Issue:3 Topics: Acetylcysteine; Adenosine Triphosphate; Amyotrophic Lateral Sclerosis; Blotting, Western; Caspase 3; Caspases; Cell Death; DNA Fragmentation; Fluorescent Antibody Technique; Free Radical Scavengers; Humans; L-Lactate Dehydrogenase; Mitochondria; Mutation; Neuroblastoma; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured	2003
Low levels of ALS-linked Cu/Zn superoxide dismutase increase the production of reactive oxygen species and cause mitochondrial damage and death in motor neuron-like cells. Journal of the neurological sciences, 2005, May-15, Volume: 232, Issue:1-2 Topics: Amyotrophic Lateral Sclerosis; Blotting, Western; Cell Death; Cell Division; Cell Line; Cell Proliferation; Cell Survival; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Humans; Membrane Potentials; Mitochondria; Motor Neurons; Reactive Oxygen Species; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Transfection	2005
Inhibition of glycogen synthase kinase-3 suppresses the onset of symptoms and disease progression of G93A-SOD1 mouse model of ALS. Experimental neurology, 2007, Volume: 205, Issue:2 Topics: Amyotrophic Lateral Sclerosis; Animals; Blotting, Western; Caspase 3; Cell Death; Cyclooxygenase 2; Cytochromes c; Cytosol; Disease Progression; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Humans; In Situ Nick-End Labeling; Intercellular Adhesion Molecule-1; Mice; Mice, Transgenic; Motor Neurons; Poly(ADP-ribose) Polymerases; Postural Balance; Spinal Cord; Superoxide Dismutase; Superoxide Dismutase-1; Thiazoles; Urea	2007
Riluzole for amyotrophic lateral sclerosis. The Medical letter on drugs and therapeutics, 1995, Dec-08, Volume: 37, Issue:963 Topics: Amyotrophic Lateral Sclerosis; Controlled Clinical Trials as Topic; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Muscles; Riluzole; Sodium Channels; Thiazoles; Tracheostomy; Treatment Outcome	1995
From the Food and Drug Administration. JAMA, 1995, Jul-26, Volume: 274, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Drug Labeling; Drugs, Investigational; Humans; Product Surveillance, Postmarketing; Riluzole; Theophylline; Thiazoles; United States; United States Food and Drug Administration	1995
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Research Design; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Excitatory Amino Acid Antagonists; Humans; Research Design; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Research Support as Topic; Riluzole; Thiazoles	1994
Neuroprotective effects of riluzole in ALS CSF toxicity. Neuroreport, 1994, Apr-14, Volume: 5, Issue:8 Topics: Amyotrophic Lateral Sclerosis; Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Humans; Neurons; Neurotoxins; Rats; Receptors, Glutamate; Riluzole; Thiazoles	1994
Riluzole in amyotrophic lateral sclerosis. The New England journal of medicine, 1994, Jul-28, Volume: 331, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1994
Riluzole for the treatment of amyotrophic lateral sclerosis--too soon to tell? The New England journal of medicine, 1994, Mar-03, Volume: 330, Issue:9 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1994
Riluzole and amyotrophic lateral sclerosis. Lancet (London, England), 1996, Aug-03, Volume: 348, Issue:9023 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Humans; Neuroprotective Agents; Patient Dropouts; Proportional Hazards Models; Reproducibility of Results; Riluzole; Risk; Thiazoles	1996
[Riluzole for everybody or for nobody]. Neurologia (Barcelona, Spain), 1996, Volume: 11, Issue:1 Topics: Amyotrophic Lateral Sclerosis; Excitatory Amino Acid Antagonists; Humans; Riluzole; Thiazoles	1996
The impact of the approval of riluzole. Neurology, 1996, Volume: 47, Issue:4 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
Rilutek (Riluzole) may extend survival in amyotrophic lateral sclerosis. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses, 1996, Volume: 28, Issue:4 Topics: Amyotrophic Lateral Sclerosis; Double-Blind Method; Humans; Neuroprotective Agents; Randomized Controlled Trials as Topic; Riluzole; Survival Analysis; Thiazoles; Tracheostomy	1996
Riluzole and amyotrophic lateral sclerosis: did potential market size bias pharmaceutical research? Archives of neurology, 1996, Volume: 53, Issue:11 Topics: Amyotrophic Lateral Sclerosis; Drug Industry; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
Riluzole. Lancet (London, England), 1996, Dec-14, Volume: 348, Issue:9042 Topics: Aged; Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Humans; Neuroprotective Agents; Publishing; Riluzole; Thiazoles	1996
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Annals of neurology, 1996, Volume: 39, Issue:2 Topics: Acetates; Amines; Amyotrophic Lateral Sclerosis; Animals; Brain; Cyclohexanecarboxylic Acids; Diet; Disease Progression; Gabapentin; gamma-Aminobutyric Acid; Humans; Mice; Mice, Transgenic; Oxidative Stress; Riluzole; Spinal Cord; Superoxide Dismutase; Survival Analysis; Thiazoles; Vitamin E	1996
[Riluzole treatment in amyotrophic lateral sclerosis]. Nederlands tijdschrift voor geneeskunde, 1996, Nov-16, Volume: 140, Issue:46 Topics: Amyotrophic Lateral Sclerosis; Controlled Clinical Trials as Topic; Drug Costs; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
[Neuroprotective therapy for amyotrophic lateral sclerosis (ALS)]. Rinsho shinkeigaku = Clinical neurology, 1996, Volume: 36, Issue:12 Topics: Amyotrophic Lateral Sclerosis; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1996
Amyotrophic lateral sclerosis: from pathological mechanisms to patient care. Journal of neurology, 1997, Volume: 244 Suppl 2 Topics: Amyotrophic Lateral Sclerosis; Animals; Excitatory Amino Acid Antagonists; Humans; Neuroprotective Agents; Point Mutation; Riluzole; Superoxide Dismutase; Thiazoles	1997
Riluzole--what is its impact in our treatment and understanding of amyotrophic lateral sclerosis? The Annals of pharmacotherapy, 1997, Volume: 31, Issue:6 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Neuroprotective Agents; Riluzole; Thiazoles	1997
Practice advisory on the treatment of amyotrophic lateral sclerosis with riluzole: report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 1997, Volume: 49, Issue:3 Topics: Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administration Schedule; Excitatory Amino Acid Antagonists; Humans; Neurology; Riluzole; Societies, Medical; Thiazoles; Treatment Outcome	1997