thiamphenicol-glycinate-acetylcysteinate has been researched along with Haemophilus-Infections* in 1 studies
1 other study(ies) available for thiamphenicol-glycinate-acetylcysteinate and Haemophilus-Infections
| Article | Year |
|---|---|
Serum and lung levels of thiamphenicol after administration of its glycinate N-acetylcysteinate ester in experimentally infected guinea pigs.
Thiamphenicol is an analogue of chloramphenicol and is characterised by a broad spectrum of action. In this study, serum and lung levels of thiamphenicol (TAP) were studied in infected guinea pigs after the administration of thiamphenicol glycinate N-acetylcysteinate (TGA). Animals received a single dose of TGA (15 mg/kg, subcutaneously) immediately after intra-tracheal infection with Haemophilus influenzae (about 10(7) CFU/animal). Serum and lung concentrations of TAP were determined at 0, 1, 3, 6, 12 and 24 h after drug administration by means of HPLC. TAP serum levels were elevated at 1 h and remained detectable for 24 h after drug administration. Tissue lung levels were comparable to peak serum concentrations but remained higher and decreased more slowly than serum concentrations. Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Colony Count, Microbial; Drug Combinations; Female; Guinea Pigs; Haemophilus Infections; Haemophilus influenzae; Injections, Subcutaneous; Lung; Thiamphenicol | 2000 |